CN1806859A - Compound system implanter unit for local tissue engineering - Google Patents
Compound system implanter unit for local tissue engineering Download PDFInfo
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- CN1806859A CN1806859A CN 200610023635 CN200610023635A CN1806859A CN 1806859 A CN1806859 A CN 1806859A CN 200610023635 CN200610023635 CN 200610023635 CN 200610023635 A CN200610023635 A CN 200610023635A CN 1806859 A CN1806859 A CN 1806859A
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- polylactic acid
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Abstract
The invention discloses a local structure engineering compound system implantation unit in the medical engineering domain, which comprises the following parts: polylactic acid/ Gegenbaur's osteoblast architecture and titanium/titanium ball-bioactivity ceramics architecture, wherein the polylactic acid/ Gegenbaur's osteoblast architecture is formed by compositing of polylactic acid slice and autologous Gegenbaur's osteoblast forming by external evoking; the equidistant feed-through is spread all over the polylactic acid slice; the titanium/titanium ball-bioactivity ceramics architecture includes titanium ball texture surface, round feed-through and metal base, bioactivity ceramic film; the titanium ball texture surface is formed with titanium ball in parallel array; the titanium ball corresponds to feed-through of polylactic acid slice; the bioactivity active ceramic film is covered on titanium ball texture surface, inner surface of round feed-through and the surface of metal base. The invention can assemble on labourer joint surface, which replaces artificial bone replacement to restore bone defection.
Description
Technical field
What the present invention relates to is a kind of implant of medical engineering technical field, and specifically, what relate to is a kind of compound system implant unit that is used for the local organization through engineering approaches.
Background technology
Titanium and titanium alloy owing to have the proportion that approaches skeleton, mechanical strength and processing characteristics, biocompatibility and corrosion resistance are widely used in the medical science implant preferably.But can't form chemical bonding with osseous tissue behind the metal implant implant into body, easily make between implant and the body bone tissue and form fiber kystis, clinical effectiveness at a specified future date may cause implant loosening.And behind preparation bioactive ceramics film on the metal surface, can make implant have the mechanical property of metal material and the biological activity and the bone conductibility of bioactive ceramics simultaneously, can shorten the time of patient's knitting greatly, thereby quicken patient's rehabilitation.
Osteoblast can directly be differentiated to form bone matrix on bioactive ceramics HA film surface, produces certain thickness amorphous domain, and collagenous fiber bundle can be grown between this zone and the cell, and the bone mineral crystallization also forms in this zone.Along with finishing of mineralising, amorphous band dwindles and forms the bonding zone.Polylactic acid PLA is a kind of typical synthetic organic degradable polymer, and the degraded back generates lactic acid, has reliable biological safety., can support osteoblasticly to adhere to, move and grow as the extracellular support with the porous polylactic acid PLA, at PLA constantly after the degraded, form osseous tissue and substitute and grows into.The modification of implant surfaces morphological method as adopting titanium ball surface and porous surface, also can be regulated the reaction after cell and tissue are implanted it.And because mechanical locking action, the inside growth of bone can increase the fastness and the stability of implant.
By prior art documents, identical with theme of the present invention or similar bibliographical information is not arranged as yet so far.
Summary of the invention
The present invention is directed to deficiency of the prior art, a kind of compound system implant unit that is used for the local organization through engineering approaches is provided.Make its combination, can be combined in the artificial joint surface, perhaps artificial bone repairing bone defect as an alternative by medical inert metal material and alloy surface activation technology and inducting osseous tissue regeneration technology.
The present invention is achieved by the following technical solutions, the present invention includes polylactic acid/osteoblast system and titanium/titanium ball-bioactive ceramics system.
Described polylactic acid/osteoblast system be by the polylactic acid sheet with through external evoked being compounded to form from body is osteoblastic of forming, wherein, evenly spread all over equidistant through hole on the polylactic acid sheet, the aperture is 1000-1500 μ m, spacing is 1/2 times of aperture, i.e. 500-750 μ m.
Described polylactic acid sheet is the microcosmic loose structure, and the aperture is 100-400 μ m, and porosity is 30-80%.
Described titanium/titanium ball-bioactive ceramics system comprises titanium spherical structure surface, manhole and metallic substrates, and the bioactive ceramics film.Titanium spherical structure surface is to be made of titanium ball parallel array, and the titanium bulb diameter is 1000-1500 μ m, and adjacent two sphere gaps are 1/2 times of sphere diameter arbitrarily, and promptly 500-750 μ m is corresponding with the through hole on the polylactic acid sheet.Be interspersed between manhole and the titanium ball, be distributed with 5 manholes between promptly per 4 adjacent titanium balls, the mid point of promptly any 2 titanium ball center lines has a manhole.The manhole diameter is 200-500 μ m, and the titanium ball is about 9/10 times diameter in the metallic substrates upper height, i.e. 900-1350 μ m.The bioactive ceramics film covers on the inner surface and metal substrate surface that comprises titanium spherical structure surface, manhole.
Described titanium spherical structure surface and metallic substrates are biocompatible materials, can select titanium, titanium alloy and stainless steel material for use.Titanium spherical structure surface and metallic substrates are monolithic construction.
Described bioactive ceramics film is hydroxyapatite, tricalcium phosphate, bioactivity glass and glass ceramics, and thickness is 1-50 μ m.
Compound system implant of the present invention can be designed as different shape and size.
The present invention adopts titanium/titanium ball/bioactive ceramics-polylactic acid/osteoblast compound system to realize.At titanium/titanium ball/bioactive ceramics surface skeletonization, in the continuous degradation process of organic degradation material polylactic acid PLA, form the replacement bone tissue by osteoblast, form certain thickness active osteoplaque.Surface titanium spherical structure provides mechanical sealed attachment point for tissue growth, and the manhole on the metallic matrix to be inside and outside mass exchange, tissue growth and strong bonded provide convenience.Soft tissue is grown into and is combined with new life's active osteoplaque formation outside the compound system implant simultaneously.
Description of drawings
Fig. 1 structural representation of the present invention
Fig. 2 compound system implant unit of the present invention combination sketch map in actual applications
The specific embodiment
As shown in Figure 1, the present invention includes: polylactic acid/osteoblast system 1 and titanium/titanium ball-bioactive ceramics system 2.
Described polylactic acid/osteoblast system 1 be by polylactic acid sheet 3 with through external evoked being compounded to form from body is osteoblastic of forming, wherein, evenly spread all over equidistant through hole 4 on the polylactic acid sheet 3, the aperture is 1000-1500 μ m, spacing is 1/2 times of aperture, i.e. 500-750 μ m.
Described polylactic acid sheet 3 is the microcosmic loose structure, and the aperture is 100-400 μ m, and porosity is 30-80%.
Described titanium/titanium ball-bioactive ceramics system 2 comprises titanium spherical structure surface 5, manhole 6 and metallic substrates 7, and bioactive ceramics film 8.Titanium spherical structure surface 5 is to be made of titanium ball parallel array, and the titanium bulb diameter is 1000-1500 μ m, and adjacent two sphere gaps are 1/2 times of sphere diameter arbitrarily, and promptly 500-750 μ m is corresponding with the through hole 4 on the polylactic acid sheet.Be interspersed between manhole 6 and the titanium ball, be distributed with 5 manholes between per 4 adjacent titanium balls, the mid point of promptly any 2 titanium ball center lines has a manhole.The manhole diameter is 200-500 μ m.The titanium ball is about 9/10 times diameter in the metallic substrates upper height, i.e. 900-1350 μ m.The bioactive ceramics film covers on the surface of the inner surface of titanium spherical structure surface 5, manhole 6 and metallic substrates 7.
Described titanium spherical structure surface 5 and metallic substrates 7 are biocompatible materials, can select titanium, titanium alloy and stainless steel material for use.Titanium spherical structure surface 5 and metallic substrates 7 are monolithic construction.Can adopt the direct machine-shaping of the powder sintered rapid forming system SLS of selective laser, perhaps adopt photocureable rapid shaping system (SLA) to process mold, use the vacuum centrifugal casting molding then.
Described bioactive ceramics film 8, its material are hydroxyapatite, tricalcium phosphate, bioactivity glass and glass ceramics, and thickness is 1-50 μ m.
The present invention can be according to different requirements, and Design and Machining forms difformity and size.
As shown in Figure 2, in the implant surgery process, the joint of polylactic acid/osteoblast system 1 and titanium/titanium ball-bioactive ceramics system 2 is by chimeric the finishing between the surperficial titanium ball 5 of the through hole 4 in polylactic acid/osteoblast system 1 and titanium/titanium ball/bioactive ceramics system 2.
If as artificial joint local organization through engineering approaches unit, then titanium among the present invention/titanium ball-bioactive ceramics system 2 and artificial joint riveted or welding in operation process, can be made up polylactic acid/osteoblast system 1 with it.
Claims (10)
1, a kind of compound system implant unit that is used for the local organization through engineering approaches, it is characterized in that, comprise: polylactic acid/osteoblast system (1) and titanium/titanium ball-bioactive ceramics system (2), described polylactic acid/osteoblast system (1) be by polylactic acid sheet (3) with through external evoked being compounded to form from body is osteoblastic of forming, wherein, evenly spread all over equidistant through hole (4) on the polylactic acid sheet (3); Described titanium/titanium ball-bioactive ceramics system (2) comprises titanium spherical structure surface (5), manhole (6) and metallic substrates (7), and bioactive ceramics film (8), titanium spherical structure surface (5) is to be made of titanium ball parallel array, the titanium ball is corresponding with the through hole (4) on the polylactic acid sheet, and bioactive ceramics film (8) covers on the surface of the inner surface of titanium spherical structure surface (5), manhole (6) and metallic substrates (7).
2, the compound system implant unit that is used for the local organization through engineering approaches according to claim 1 is characterized in that, described titanium bulb diameter is 1000-1500 μ m, and adjacent two sphere gaps are 500-750 μ m arbitrarily.
3, according to claim 1 or the 2 described compound system implant units that are used for the local organization through engineering approaches, it is characterized in that described titanium ball is 900-1350 μ m in metallic substrates (7) upper height.
4, the compound system implant unit that is used for the local organization through engineering approaches according to claim 1, it is characterized in that, be interspersed between described manhole (6) and the titanium ball, be distributed with 5 manholes (6) between per 4 adjacent titanium balls, the mid point of promptly any 2 titanium ball center lines has a manhole (6).
5, according to claim 1 or the 4 described compound system implant units that are used for the local organization through engineering approaches, it is characterized in that described manhole (6) diameter is 200-500 μ m.
6, the compound system implant unit that is used for the local organization through engineering approaches according to claim 1 is characterized in that, described through hole (4) aperture is 1000-1500 μ m, and spacing is 500-750 μ m.
7, the compound system implant unit that is used for the local organization through engineering approaches according to claim 1 is characterized in that, described polylactic acid sheet (3) is the microcosmic loose structure, and the aperture is 100-400 μ m, and porosity is 30-80%.
8, the compound system implant unit that is used for the local organization through engineering approaches according to claim 1, it is characterized in that, described titanium spherical structure surface (5) and metallic substrates (7) are monolithic construction, both materials are biocompatible materials, described biocompatible materials is titanium, titanium alloy or stainless steel material.
9, the compound system implant unit that is used for the local organization through engineering approaches according to claim 1, it is characterized in that, described bioactive ceramics film (8), its material are hydroxyapatite, tricalcium phosphate, bioactivity glass or glass ceramics, and thickness is 1-50 μ m.
10, the compound system implant unit that is used for the local organization through engineering approaches according to claim 1, it is characterized in that both joints are by chimeric the finishing between the surperficial titanium ball (5) of the through hole (4) in polylactic acid/osteoblast system (1) and titanium/titanium ball/bioactive ceramics system (2).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100236359A CN100355467C (en) | 2006-01-26 | 2006-01-26 | Compound system implanter unit for local tissue engineering |
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| CNB2006100236359A CN100355467C (en) | 2006-01-26 | 2006-01-26 | Compound system implanter unit for local tissue engineering |
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| CN1806859A true CN1806859A (en) | 2006-07-26 |
| CN100355467C CN100355467C (en) | 2007-12-19 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1081072C (en) * | 1997-11-19 | 2002-03-20 | 华南理工大学 | Method for preparing artificial joint with bio-active gradient coating |
| CN1201826C (en) * | 2003-08-07 | 2005-05-18 | 南京大学医学院附属口腔医院 | Method for preparing high activity bone defect repairing material |
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