CN1800413A - Helicobacter pylori pathogenicity island disease gene detection chip - Google Patents

Abstract

The invention discloses a pylorus spirobacteria affection gene test chip in the field of clinical medicine application. The chip sets a probe which comprises SEQ ID NO: 1-26 above 85% conservative sequence PCR product; the PCR product is a characteristic primer which uses international standard culture HP26695 (or J99) as reference sequence; it uses the gene group DNA extracted from Chinese people affection characteristic pylorus spirobacteria strain as table to obtain the product by PCR reacting. It also discloses a method for preparing for pylorus spirobacteria cag affection characteristic gene test chip.

Description

Helicobacter pylori pathogenicity island disease gene detection chip

Technical field

The invention belongs to the clinical medicine Application Areas, relate to a kind of gene detecting chip, further, the present invention relates to helicobacter pylori pathogenicity island disease gene detection chip.

Background technology

Helicobacter pylori (H.pylori) infects more than 50% of world population, China adult infection rate 60-70%, clinical data shows that the infection of H.pylori is directly related with diseases such as peptide ulceration, chronic gastritis, gastric mucosa Lymphoid tissue sample lymphoma and cancer of the stomach.The same with other pathogenic bacterium, the Disease-causing gene great majority of H.pylori concentrate on the DNA zone that is called as the cag pathogenicity island with the gene in close relations that causes a disease.H.pylori cag pathogenicity island genome has bigger variation, has determined the difference of its virulence (pathogenecity), also is one of different clinical infection final result important factors to occur.Understand H.pylori cag pathogenicity island genome polymorphism and important meaning is all arranged for the mechanism of causing a disease of judging disease prognosis, select to treat decision-making and further study H.pylori.

At present, in molecular biology and medical science association area, H.pylori cag pathogenicity island genome polymorphism research method mainly contains two classes.One class is the Protocols in Molecular Biology that is used for the analyzing gene structure, relates to technology such as polymerase chain reaction,PCR (PCR), dna sequencing, restriction enzyme zymotechnic and gel electrophoresis.Principle is to be template with the target nucleic acid molecules, obtains specific fragment by the PCR operation, understands its constitutional features by technology such as order-checkings again.But, existing Protocols in Molecular Biology complex operation, each experiment flow can only be understood place's gene information, and the analysis that finish 30 genes of cag pathogenicity island and surpass 60-70 site is very huge workload and experimental period.The research of domestic these class methods of employing fails to obtain the comparatively comprehensively pathogenic specificity information of H.pylori cag pathogenicity island gene so far, therefore can not have clinical use value.

Another kind of is to adopt DNA biochip technology research H.pylori genome, external existing several pieces of bibliographical informations, principle is that fragment point sample with the contained gene of H.pylori is to gene chip, fluorescent mark H.pylori nucleic acid to be measured sample and chip hybridization are arranged, obtain the genomic information of the H.pylori that surveys again by the scanner uni information processing.But, the main purpose of the genomic gene chip research of H.pylori at present is to understand H.pylori whole genome global feature and integrity, fail to analyze the detail with the maximally related pathogenicity island gene of its virulence, useful clinically information can not fully be provided.And the chip-scale of whole genome is bigger, and the expense costliness is not suitable for clinical application.Moreover the H.pylori cag pathogenicity island genome signature that population of China infects has than big-difference with external bacterial strain, and Hesperian data and research tool are not suitable for researching and analysing of China's bacterial strain.

China is that H.pylori infects the district occurred frequently, China H.pylori bacterial strain cag pathogenicity island integrity is higher, by our research, the gene structure obvious difference, there is the cag pathogenicity island gene expression characteristics testing tool of clinical meaning should contain comparatively specifically and has clinical information targetedly more.The present invention is that by the Clinical symptoms correlation analysis, design comprises the detection gene chip of cag pathogenicity island gene and specific gene internal structure details on the basis that obtains population of China H.pylori disease specific bacterial strain cag pathogenicity island complete genome sequence.Can solve the deficiency that prior art exists preferably.

The present invention thinking and technical support derive from the progress in three fields.Biochip technology in the first biotechnology, just gene micromatrix technology (microarry).Principle be on carriers such as glass, silicon in an orderly manner, to high-density (at present between points distance less than 500 μ m) arrange, fixing a large amount of target fragment (also claiming molecular probe).Sample nucleic acid molecule is hybridized with the DNA array that is fixed on the carrier simultaneously through mark, and hybridization information intensifies and parallel processing by computer, is exactly biochip technology.Compare with traditional gene studies method, the outstanding feature of this technology is unrivaled high information quantity, and high-throughput is analyzed thousands of genomic informations quickly and accurately, have high working efficiency, be described as " laboratory on the chip " (Lab-on-a-chip).It two is helicobacter pylori classification culture techniques.Principle is little aerobic environment and the appropriate nutrient environment that in-vitro simulated helicobacter pylori grows in stomach, by gastroscopy acquisition H.pylori and at cultured and amplified in vitro.It three is the Protocols in Molecular Biologies of being correlated with, and comprises bacterial genomes DNA separation and purification and fluorescent mark.Principle is to utilize chemical reagent to destroy thalline nucleic acid composition in addition, again by technology such as separation absorption, obtains the genomic dna of test purity requirement.The present invention utilizes prior art, from solving the angle of a clinical difficult problem, invented a kind of can be disposable the understanding clinical case infect the H.pylori cag pathogenicity island instrument of gene information comprehensively.

Summary of the invention

Technical problem to be solved by this invention is to provide: a kind of helicobacter pylori pathogenicity island disease gene detection chip, be set with probe on the described chip, described probe comprises the PCR product of 85% above conserved sequence among the SEQ ID NO:1-26, described PCR product is to design Auele Specific Primer with international standard bacterial strain HP26695 sequence for reference sequences, the genomic dna that extracts with clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain obtains through the PCR reaction as template.

Further, the present invention also aims to provide a kind of helicobacter pylori pathogenicity island disease gene detection chip, also be set with the cag pathogenicity island gene specific oligonucleotide among the SEQ ID NO:27-40 on the described chip.

Selectively, helicobacter pylori pathogenicity island disease gene detection chip of the present invention in the preparation, described PCR product also can design Auele Specific Primer for reference sequences with the sequence of international standard bacterial strain J99.

Further, the present invention also aims to provide a kind of making method of helicobacter pylori pathogenicity island disease gene detection chip, comprising: in the H.pylori infected patient, choose representative bacterial strain, measure its whole genome sequence; Compare with known reference culture HP26695 sequence, find out specific dna polymorphism feature; With reference to conserved sequence design PCR primer, the genomic dna that clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain is extracted is as template, obtains product as one of probe of DNA gene chip through the PCR reaction; Obvious and the conserved sequence shorter one for gene inside polymorphism, the oligonucleotide fragment of increase over-designed sequence open reading frame (ORF) fragment correspondence; Manufacture craft according to the DNA gene chip prepares the DNA gene chip.

Further, in the making method of helicobacter pylori pathogenicity island disease gene detection chip of the present invention, comprise the following steps:

A) choose patients with gastric cancer, duodenal ulcer patients or chronic gastritis patient in the H.pylori infected patient, obtain representative bacterial strain, and order-checking obtains its whole genome sequence;

B) compare with known reference culture HP26695 sequence, and different representative strain cag pathogenicity island gene orders are compared, seek specific dna polymorphism feature;

C) with reference to conserved sequence design PCR primer, the genomic dna that clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain is extracted is as template, obtains product as one of probe of DNA gene chip through the PCR reaction; Obvious and the conserved sequence shorter one for gene inside polymorphism increases the corresponding oligonucleotide fragment of over-designed sequence open reading frame (ORF) fragment (oligoDNA of 70bp, sequence SEQ ID NO:27-40), and synthetic this fragment conduct is probe additionally;

D) according to the manufacture craft of DNA gene chip, probe is imprinted on pretreated slide through the point sample instrument point,, makes finished product DNA gene chip through technique for fixing.

Selectively, in the making method of helicobacter pylori pathogenicity island disease gene detection chip of the present invention, compare, find out the dna sequence polymorphism feature with the sequence of known reference culture J99.

On the other hand, technical problem to be solved by this invention also is to provide the quality control and the detection efficiency verification method of described helicobacter pylori pathogenicity island disease gene detection chip, it is characterized in that, comprises the following steps:

A) amount DNA sample to be measured (deriving from helicobacter pylori genome DNA to be measured) obtains different fluorescently-labeled hybridization samples through the reverse transcription of nine aggressiveness Cy3-dCTP or Cy5-dCTP fluorescent mark raw material at random;

B) sample purifying;

C) chip hybridization experiment;

D) the machine fluorescent scanning obtains the hybridization signal data as calculated;

E) the fluorescent signal data are calculated the Ratio value of Cy5/Cy3 through standardization, and the Ratio value that all hybridization points are corresponding all is qualified between 0.5-2.0.

On the other hand, technical problem to be solved by this invention also is to provide the using method of described helicobacter pylori pathogenicity island disease gene detection chip, comprises the following steps:

B) check that the helicobacter pylori infection person gastric mucosa tissue sample obtain through separating, cultivating 48 hours, obtains bacterial strain to be measured, and obtains the genomic dna of bacterial strain to be measured through DNA separation and purification operation;

C) relevant aforesaid method obtains fluorescent mark sample to be measured (reference culture DNA is with the Cy3 fluorescent mark, and bacterial strain DNA to be measured is with the Cy5 mark);

D) carry out chip hybridization experiment, the line data analysis of going forward side by side.

The present invention is used to detect clinical patients (host) and infects helicobacter pylorus bacteria strain cag pathogenicity island disease specific gene type.Understand these genotype, to the different infection outcomes of prognosis, formulate treatment and provide guidance with anti-strategy.

Characteristics of the present invention are to have the closest clinical connection, we select most representative clinical data: (H.pylori infection medical history is longer to choose patients with gastric cancer in the H.pylori infected patient, considering has dependency most), (it is longer that H.pylori infects medical history for duodenal ulcer patients and lighter chronic gastritis patient, consider that the H.pylori virulence is weak), separation and Culture and mono-clonalization (dna fingerprint analysis) obtain representative bacterial strain.The bacterium sample derives from gastroscopic gastric mucosa tissue sample.As in an embodiment of the present invention, the inventor is from having obtained 161b, 813f, g3e bacterium clinically.With microbionation in Columbia nutrient agar (horse blood 7% adds Skirrow selectivity microbiotic), three gas incubator (N ₂85%, CO ₂10%, O ₂5%) cultivates 48 hours receipts bacterium.

Then, is (specifying information of HP26695 described in: http: ∥ www.tigr.org/tigr-scripts/CMR2/GenomePage3.spl with international standard bacterial strain HP26695? database=ghp) be template, use suitable primer-design software (as Primer Premier5 software) design PCR primer, PCR reaction and order-checking obtain the whole genome sequence of above-mentioned representative strain cag pathogenicity island repeatedly, the PCR product of acquisition ordinary method purifying, order-checking.Compare with foreign standard bacterial strain HP26695 sequence, and different representative strain cag pathogenicity island gene orders are compared, seek specific dna polymorphism.Perhaps, selectively, also can be with the sequence [http: ∥ www.ncbi.nlm.nih.gov/entrez/viewer.fcgi of international standard bacterial strain J99? db=nucleotide﹠amp; Val=15611071, GeneBank accession number: NC_000921] design Auele Specific Primer for reference sequences.

Next, with regard to the oligonucleotide fragment of difference design chips point sample (increasing the corresponding oligonucleotide fragment of over-designed sequence open reading frame (ORF) fragment (oligoDNA of 70bp) for the tangible gene of partial interior polymorphism), the PCR product that gene pairs is answered is jointly as the chip spotting template.The mark of DNA sample to be measured adopts nine aggressiveness, Cy3-dCTP or Cy5-dCTP and KlenowFragment at random.Probe purifying and chip hybridization, scanning analysis.

Should understand, obtained specific cag pathogenicity island gene order by method of the present invention after, those skilled in the art is with reference to dna sequence dna provided by the present invention and thinking, can prepare probe of the present invention by range gene engineering means very easily, this product that obtains by different approaches is also contained in this equally

In the scope of invention.

This invention can be filled up the vacancy at present domestic and international special detection H.pylori cag pathogenicity island and clinical infection final result genes involved integrity and the polymorphism.Compared with prior art, overcome traditional Protocols in Molecular Biology heavy work amount and poor efficiency, can obtain the full genomic gene chip analysis of H.pylori can not provide concrete and have more the information of clinical value.Chip-scale of the present invention is less, cost is low and quantity of information is very big.

Embodiment

The invention discloses a kind of helicobacter pylori pathogenicity island disease gene detection chip and preparation method thereof, on modified slide glass, be fixed with probe, wherein, described probe comprises the sequence that a kind of and SEQ ID NO:1-26 sequence have 85% above homology at least.

Because the present invention designs corresponding primer with reference to the international standard bacterial strain, with domestic people's helicobacter pylorus bacteria strain be template, obtain gene probe, preparation DNA micromatrix is as the instrument of the detection of disease.Domestic people's helicobacter pylorus bacteria strain homology is very high, in this embodiment, only enumerated the chip that some bacterial strains of obtaining clinically with the inventor obtain in contrast, those skilled in the art are easy to from obtaining other bacterial strain clinically, the probe of certain difference of showing in acquisition and this example, thus may prepare different chips.Therefore, should be understood that probe and chip that these the method according to this invention and thinking obtain comprise within the scope of the invention.

In following embodiment, described point sample probe is following acquisition, at first, chooses patients with gastric cancer, duodenal ulcer patients and lighter chronic gastritis patient in the H.pylori infected patient, and separation and Culture and mono-clonalization obtain representative bacterial strain.In the present embodiment, utilization of the present invention is cultivated microbionation from having obtained representational 161b, 813f, g3e bacterium clinically.Then, with international standard bacterial strain HP26695 (or J99) is template, design PCR primer, PCR reaction and order-checking obtain the whole genome sequence of above-mentioned representative strain cag pathogenicity island repeatedly, compare with HP26695 (or J99) sequence, and different representative strain cag pathogenicity island gene orders are compared, seek specific dna polymorphism.Then, with reference to conserved sequence design PCR primer, the genomic dna that extracts with clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain obtains the probe of product as the DNA gene chip as template through the PCR reaction.

Further, the obvious and conserved sequence shorter one for gene inside polymorphism, the oligonucleotide fragment of increase over-designed sequence open reading frame (ORF) fragment correspondence, synthetic described fragment is as extra probe.Therefore, on gene chip of the present invention, also be fixed with at least a probe, the oligonucleotide sequence of described probe is shown in table 2 (SEQ ID NO:27-40).

The design and the making of embodiment 1 chip

1.H.pylori cultivation and evaluation

Choose patients with gastric cancer, duodenal ulcer patients and lighter chronic gastritis patient in the H.pylori infected patient, separation and Culture and mono-clonalization obtain representative bacterial strain.

With microbionation in the Columbia nutrient agar, add 7% horse blood (Shanghai institute of Biological Products), add Skirrow selectivity antibiont (5mg/l TMP, 10mg/ml vancomycin and 2500U/l PXB and 5mg/l amphotericin) again, (N under 37 ℃ of little oxygen conditions in three gas incubators ₂85%, CO ₂10%, O ₂5%) cultivates, collect thalline during 48h.Identify ne ar and vigor through colonial morphology, smear staining and biochemical reaction (urease, oxydase and catalase), obtain suitable bacterium.

2., primer design

The inventor has obtained 161b, 813f, the representative bacterial strain of g3e from clinical H.pylori infected patient, adopt foregoing method to cultivate, then, extract the DNA of bacterial strain, carry out genome sequencing, the whole genome sequence of the 161b that obtains is seen SEQ ID NO:117 (161b-1 has listed its complete genomic 11-11395 position Nucleotide) and SEQ ID NO:118 (161b-2 has listed its complete genomic 13040-39189 position Nucleotide); The 813f that obtains sees SEQ ID NO:119 (813f-1 has listed its complete genomic 7-11146 position Nucleotide) and SEQ ID NO:120 (813f-2 has listed its complete genomic 13349-39217 position Nucleotide); The g3e that obtains sees that (g3e-2 has listed its complete genomic 13155-38626 position Nucleotide for SEQ ID NO:121 (g3e-1 has listed its complete genomic 1-11329 position Nucleotide) and SEQ ID NO:122.Wherein, above-mentioned bacterial strains is in the order-checking process, part sequence is because AT content height, primer binding site is many, poor specificity, and PCR product band is many, order-checking can't be surveyed logical, therefore having lacked some Nucleotide on the site that has, is minute quantity Nucleotide owing to what lack still, does not influence follow-up primer and probe design.

With the sequence of above-mentioned acquisition and the sequence of known reference culture HP26695 (referring to as http: ∥ www.tigr.org/tigr-scripts/CMR2/GenomePage3.spl? database=ghp) compare, seek specific dna polymorphism feature.Obtain strain gene specificity ORF and gene internal specific variation fragment, synthetic these fragments that obtains of PCR operation or DNA.The principle of PCR operation design of primers is that length mostly is 18bp-22bp, has 52 ℃-56 ℃ best of melting temperature(Tm)s and the minimum possibility that forms secondary structure and hairpin structure.In order to guarantee that the gene fragment on the chip can detect corresponding gene specifically, the ORF sequence of submitting to the design of primers program do not comprise with the genome other parts have intersect homology the zone and with contiguous ORF overlapping areas.The homologous genes sequence length is greater than 85%.All primer sequences carry out the homology comparison by the whole genome sequence of BLAST_2sequence (deriving from www.ncbi.nlm.nih.gov) and H.pylori 26695, and only the primer of showing unique coupling site with genome sequence is used.It is 1 listed that concrete primer selection result sees Table, and the HP0521 in the following table represents the cag2 gene of international standard bacterial strain HP26695, and HP0522 represents the cag3 gene, and the like.Owing to find that the cag1 gene is shorter, have only bp more than 300, and variation obviously, therefore only uses 70bp OligoDNA as probe, do not use the PCR product, so do not relate to the primer of cag1 here on chip.Probe with HP numbering is the PCR product, with the probe of P numbering for comprising the segmental PCR product of a plurality of gene lengths.The forward and the reverse primer that obtain see Table 1.

Table 1

				The PCR primer				The gene information of probe correspondence
												The probe numbering	PCR product 5 ' position	PCR product 3 ' position	PCR length	Forward primer (corresponding SEQ ID NO:41-78 respectively)		Reverse primer (corresponding SEQ ID NO:79-116 respectively)		Locus		Mrna length	Initial-the termination relative position
HP0521	?3103	?3346	244	HP0521+	ATgATACAAAgAggATTgAgTA	HP0521-	TTCAATCCATTgCATTTg	HP0521	cag2	243	3103-3345
												HP0522	?3517	?4597	1081	HP0522+	GCTAAAGAAATAAGTGAAGCC	HP0522-	TCTCCTTATCCACTAATAACC	HP0522	cag3	1446	3454-4899
HP0523	?4921	?5350	430	HP0523+	TGGATTGGTCTGACTTTGCT	HP0523-	GTTTCATTCCCCCATTGTAA	HP0523	cag4	510	4909-5418
												HP0524	?5333	?6494	1162	HP0524+	ACAATGGGGGAATGAAACAC	HP0524-	AGGTGAAGAAGATAAGAGTGG	HP0524	cag5	2247	5537-7783
HP0526	?8831	?9318	488	HP0526+	TTCTAAAGAAGTGAGATAAG	HP0526-	CAAATGAAGTAAAGGATAAG	HP0526	cag6	600	8789-9388
												HP0527-1	?10345	?11170	826	HP0527-1+	AAATTCCCCACTCTTTTC	HP0527-1-	AGCGAAAGAACTCCAACA	HP0527	cag7	5784	9526-15309
HP0527-2	?13479	?14272	794	HP0527-2+	GCAAGTCTTGGGGAATAT	HP0527-2-	TGGCATTGTAGTCGCTGT	HP0527	cag7	5784	9526-15309
												HP0528	?15315	?16114	800	HP0528+	ACGCCTTTTTATTTATCTCTGAC	HP0528-	CAAAAAAGCCCTGAGGATAAC	HP0528	cag8	1569	15324-16892
HP0529	?16873	?18065	1193	HP0529+	TAAAAAATGCCTGCCCCATC	HP0529-	GTTGAGGACAATGTGAAAGG	HP0529	cag9	1608	16945-18552

HP0530	18611	19266	656	HP0530+	TTCGCTTACCGTCTGTTCGT	HP0530-	GGGGTGTGATAGCCCTTGAT	HP0530	cag10	759	18557-19315
												HP0531	19749	20278	530	HP0531+	CCACCTAGCAACTCACAGAG	HP0531-	TAAATCAAATAGCCCATACC	HP0531	cag11	657	19701-20357
HP0532	20539	21234	696	HP0532+	GATACCCTTAAATGACAAAC	HP0532-	CACTTACCACTGAGCAAACT	HP0532	cag12	843	20393-21235
												HP0534	21486	22027	542	HP0534+	TTCATCAGCAAATCCCTAAC	HP0534-	AACATGCGAAAACTCTTCTC	HP0534	cag13	591	21446-22036
HP0535	22518	22841	324	HP0535+	TACCAAAACCATTACCAACC	HP0535-	TGCTTCCTACTAAAACACGC	HP0535	cag14	381	22462-22842
												HP0537	24123	24783	661	HP0537+	AACGAGATAAAAAAAGAACAAG	HP0537-	ACGCCAAGCGTTCCGAGTTAAAA	HP0537	cag16	1131	24043-25173
HP0538	25532	26045	514	HP0538+	CGCTAACCCTTTGAATGACAACC	HP0538-	GACGCTATTGGGCAGTTCAGAT	HP0538	cag17	921	25188-26108
												HP0539	26228	26871	644	HP0539+	GGTATTGTCGCTTACTTTGT	HP0539-	TTTTTTGCTCTTGTCTGTTT	HP0539	cag18	714	26190-26903
HP0540	26929	27932	1004	HP0540+	GTTTCTTGCTGTCGTTTCTC	HP0540-	CACAAGCCAAACAAAAAACC	HP0540	cag19	1146	26900-28045
												HP0541	28130	29066	937	HP0541+	GTAATCAAGATAAGTCAAATGC	HP0541-	AGGAATAGTAGCGGGTGC	HP0541	cag20	1113	28056-29168
HP0542	29210	29575	366	HP0542+	CGATGAATCTGGATATGTTGGT	HP0542-	GCTTGGTGTCTTATCATTGG	HP0542	cag21	429	29184-29612
												HP0543	29819	30430	612	HP0543+	ATGCGTGAAGTCATAGGC	HP0543-	GAAAATGATGTCTTGACGAT	HP0543	cag22	807	29667-30473

HP0544-1	32298	33349	1052	HP0544-1+	TAAACTTCTTTCACCCCACC	HP0544-1-	AAAAAAATAGAAGAACTTAAAGCAGAC	HP0544	cag23	2952	30475-33426
												HP0544-2	31252	31870	619	HP0544-2+	467TGCCGCTGCAAGCGTATTAGAAT489	HP0544-2-	TTTTTCGCCAAACATTGCTC	HP0544	cag23	2952	30475-33426
HP0545	33447	33997	551	HP0545+	GCTTCACATGTAATCGTATAA	HP0545-	CTCGTTGTTTTCAGTTCG	HP0545	cag24	624	33435-34058
												HP0546	34092	34396	305	HP0546+	GCCAAACTTAGTGCTCAA	HP0546-	TTACAAGAATCACTGACAGCT	HP0546	cag25	348	34060-34407
HP0547-1	35974	38581	2608	HP0547-1+	GCCACTACTACCACCGACATAC	HP0547-1-	AGAGTGGTTTTTGTCTCCCCAT	HP0547	cag26	3561	35241-38801
												HP0547-2	37644	38579	936	HP0547-2+	GGGCGATTTCAGTAGGGTAG	HP0547-2-	GACAAAGAAACGCTTCCCAC	HP0547	cag26	3561	35241-38801
HP0547-1-2	35974	38581	2608	HP0547-1+	GCCACTACTACCACCGACATAC	HP0547-1-	AGAGTGGTTTTTGTCTCCCCAT	HP0547	cag26	3561	35241-38801
												HP0547-2-2	37644	38579	936	HP0547-2+	GGGCGATTTCAGTAGGGTAG	HP0547-2-	GACAAAGAAACGCTTCCCAC	HP0547	cag26	3561	35241-38801
HP0547-3	35976	38583	2608	HP0547-3+	GCCACTACTACCACCGACATAC	HP0547-3-	CTGACAAAGAAACGCTTCCC	HP0547	cag26	3561	35241-38801
												HP0547-4	36780	38583	1804	HP0547-4+	ACCAACGCCTCCAAGAATCC	HP0547-4-	CTGACAAAGAAACGCTTCCC	HP0547	cag26	3561	35241-38801
HP04-6	2660	5664	3005	4+	ATCAATACAACTGAAGCAAC	6-	GCAAGAAATACAAATTGGGG	The HP0520 part, HP0521, HP0522, HP0523, HP0524 part
												P011-11	8303	9427	1125	11+	ATCGCTTGTTCTTT	11-	CGAAAAAAAAC	HP0526

					GTTGTC		CAAGCAAAAAC
									P017-19	14090	17004	2915	17+	TTGCCTTTTTCATTCCGTTC	19-	GATAGAGAAAGAGATGCCTTAATG	The HP0527 part, HP0528, HP0529 part
P022-24	18867	21669	2803	22+	TCTGCTCGGACTTTATCTAC	24-	CTTTCTTCAGTAAGCCTATC	The HP0530 part, HP0531, HP0532, HP0534 part
									P029-31	25145	27933	2789	29+	ATGTTGCCAAGAATAATCCC	31-	CACAAGCCAAACAAAAAACC	The HP0537 part, HP0538, HP0539, HP0540 part
P033-33	28666	29861	1196	33+	ATACCGCTCATCATTTCAAC	33-	AACAAAATATACCCAACCAATC	The HP0541 part, HP0542, HP0543 part
									P037-38	32300	34001	1702	37+	TAAACTTCTTTCACCCCACC	38-	AGTCTCGTTGTTTTCAGTTC	The HP0544 part, the HP0545 part

Table 2

	Oligo probe 5 ' correspondence position	Oligo probe 3 ' correspondence position	70bp-Oligo probe (corresponding SEQ ID NO:27-40 respectively)			Mrna length	Initial-the termination relative position
								OL0520	?2768	?2837	gCAggggTTTTATgTTgTgTCTTgAgCggTgCTATgggg ATTgTTgggATAATCTTTgTCgCAATAggAA	HP0520	cag1	348	2648-2995
OL0521	?3153	?3222	TTATgTAAATAAAggCggCTgTAAgggCgTTTTACgAgA AATAAATggCTCAATgAAAATggTTTgCTTg	HP0521	cag2	243	3103-3345
								OL0522	?3454	?3523	ATgTTTAgAAAACTAgCAACCgCTgTATCgCTCATAggC TTACTAACCTCTAACACTCTTTATgCTAAAg	HP0522	cag3	1446	3454-4899
OL0523	?5289	?5358	CAACAAAAgCgTgTATCAATTAgTAgAAATggCAATAgg CgCTTACAATgggggAATgAAACACAACCCT	HP0523	cag4	510	4909-5418
								OL0527	?14097	?14166	TTTCATTCCgTTCTTTCAgCAATCggTTATACTCTTgC CTTATTTggATTTCATCATTgACATAAAgATT	HP0527	cag7	5784	9526-15309
OL0528	?15580	?15649	gCAggTTggAgAgTgATgTTTTTgAAACCAAAATAAgT gAATgTgCCATCATCAAAAATTTCAgAgggCA	HP0528	cag8	1569	15324-16892
								OL0535	?22722	?22653	TTTACAggTTTATCCAgTgATTTgTTTTCTATgATATT AAATTTTTTgTTCTTCCTgATgTTAATgATgg	HP0535	cag14	381	22462-22842
OL0536	?23427	?23358	CTTATAATAAAACCTAgCTTTTTTTATTACACTACTTA TCTTTTgCTACTCgTTTCTCTCAgCATAATAA	HP0536	cag15	345	23275-23619
								OL0537	?24536	?24605	CTACCACTAAAgATAAggCTCAggCTTTgCTTCAAATg ggTgTgTTTTCTTTAgATgAAgAACAAAACAA	HP0537	cag16	1131	24043-25173
OL0538	?25188	?25257	TTgAAAAgTATCTTCAAAAAACTAggTTCTgTCgCTCT TTATTCTTTAgTTATTTATgggggCTTAAACg	HP0538	cag17	921	25188-26108

OL0542	29543	29612	gAgCgTTAAACATgCCAATgATAAgACACCAAgCAAAT AgTAATTTAATTTTATAAAAATTCgTTTTCAT	HP0542	cag21	429	29184-29612
								OL0545	33770	33839	ggACTCTATTgACAATCACgAAgTCAAAAACTTCATCT TTgATAATATCgggATTgACTTCTTTgAAAgT	HP0545	cag24	624	33435-34058
OL0546	34389	34320	ATCACTgACAgCTACAAgAAAgTTgTAgTAACTTTAgg gCTAgTggTAACAACCAATCCTTTAATggCgg	HP0546	cag25	348	34060-34407
								OL0547	37487	37556	AgCTTTgAATgAATTCAAAAATggCAAAAATAAggAT TTCAgCAAggTAACgCAAgCAAAAAgCgACCTT	HP0547	cag26	3561	35241-38801

3. the pcr amplification reaction of the preparation of template DNA and probe

With the primer of aforementioned selection as the PCR primer, the genomic dna that extracts with clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain is as template (161b of clinical acquisition, 813f, g3e as described above), carry out the PCR reaction, obtain the probe of product as the DNA gene chip.Wherein, being prepared as follows of template DNA: cultivate to scrape after 4 hours and get bacterium, in PBS, wash 1-2 time, each 10 minutes, adopt the tissue DNA extraction agent box of Qiagen company to extract the H.pylori genomic dna, and be stored in-70 ℃ standby.

Then, above-mentioned probe carries out pcr amplification.PCR reaction cumulative volume is 100 μ l.Reaction system is 10 * reaction buffer, 10.0 μ l, MgCl ₂2.0mmol/l, dNTP 200 μ mol/l, primer 10pmol, TaqDNA polysaccharase 0.6U, template DNA 20ng.Amplification condition is 94 ℃ of pre-sex change 5min, 94 ℃ of 30sec, 50 ℃ of 45sec, 72 ℃ of 1min30sec, and totally 40 circulations prolong 5min with 72 ℃ eventually.Identify by 1% agar electrophoresis whether the PCR reaction is successful, the sign of product success is that band is special, single, size is correct, and band brightness is moderate.The gene redesign primer that does not amplify first increases.

4.PCR product purification and quantitative

Adopt Millipore Multiscreen-PCR plate purified pcr product, the specification sheets that concrete purification process provides referring to Millipore company.Product behind the purifying is diluted to final concentration 600ng/ μ l with distilled water, isopyknic DMSO in addition again, 50%DMSO, wait until spot film and use.Select for use 6 not have the Human genome of homology and blank (seeing Table 3) as negative control with the helicobacter pylori genome sequence.

Table 3

con1187E04	People's gene (negative control)
		con0688A10	People's gene (negative control)
con0688A11	People's gene (negative control)
		con0688A12	People's gene (negative control)
EMPTY	Blank negative control
		EMPTY	Blank negative control

5. the treating processes behind point sample and the point sample:

Sample is taken out from 4 ℃ of refrigerators, is to adopt the Genemachine point sample instrument to carry out point sample in the environment of 50%-60% in humidity.Except with the above-mentioned probe point sample for preparing on chip; Also point sample the listed oligonucleotide probe of table 2.Each gene fragment repeats point sample 4 times.The intact back of point sample adopts crosslinked instrument CL-1000 Ultraviolet Crosslinker to carry out crosslinked under the 400mJ energy.Put chip in drying at room temperature 24h.Selective examination and the shape and the intensity of observing each point on the chip with scanner.

The hybridization of embodiment 2. chips of the present invention and DNA sample to be measured

Used reagent is all commercially available in the following crossover process, derives from the rich star gene chip companies in Shanghai, as mark III, DNA hybridization solution I, DNA hybridization solution II etc.

1. the labeling process of testing gene in the 50ul reaction system

(1) sample DNA 3 μ g is dissolved in the water, makes the solution of 25 μ l.Get the random primer 6 μ l of 1 μ g/ μ l,, placed on ice then 2 minutes in 95 ℃ of sex change 5 minutes.

(2) in the darkroom, the Klenow enzyme (50u/ul) of 1mMCy5-dCTP, the 1ul of dNTP, the 1ul of 10 * Buffer, the 2ul of adding 5ul in above-mentioned solution 37 ℃ of water-baths 2 hours, is followed mixture 95 ℃ of water-baths 2 minutes.Merge Cy5, Cy3 then, cross column purification and quality inspection.

(3) mark-on III 8ul drains.

(4) add DNA hybridization solution I (removing milt DNA) 6.5ul and hybridization solution II 6.5ul, 95 ℃ of sex change 2 minutes, 42 ℃ of hybridization 16 hours.

(5) at 50 ℃, the washing chip.

2. the prehybridization of chip

(1) prehybridization solution for preparing is placed 95 ℃, sex change 30 seconds; Handled 30 seconds with dehydrated alcohol.

(2) add 13ul DNA hybridization solution I (removing milt DNA), 95 ℃ of sex change 2 minutes.

(3) 42 ℃ of hybridization 6 hours; Distilled water washes chip then.

(4) chip is placed 95 ℃, sex change 30 seconds; Handled 30 seconds with dehydrated alcohol; Be used for marker DNA hybridization.

3. hybridization

The genomic dna mark is carried out in employing nine aggressiveness, Cy3-dCTP/Cy5-dCTP and Klenow Fragment at random, uses Cy3 and Cy5 mark with reference to sample [DNA of fluorescently-labeled 26695 bacterial strains] and test specimen [DNA of fluorescently-labeled bacterial strain to be measured] respectively.Step: 1). the genome DNA sample of ultrasonic grinding.2). get the genome DNA sample after 2ug pulverizes, add 8ul 2.5 * random primer/reaction buffer,, place 5min then on ice in 100 ℃ of sex change 5min.3). add 2ul 10 * dNTP mixture, 1.2ulCy5-dCTP or Cy3-dCTP (Amersham, 1mM stocks), 0.5ul klenow Fragment, reaction mixture was 37 ℃ of insulations 3 hours.4). in the PCR pipe, add 2 μ l 0.5M EDTA (pH8.0) with termination reaction.5) purifying of fluorescent probe and crossover process.Unabsorbed fluorescence dye adopts QIAquick NucleotideRemoval Kit, and (Qiagen Germany) removes.Step: after labeled reactant finishes, add the damping fluid PN of 10 times of volumes, 6000rpm, centrifugal 30sec.Add 750ul damping fluid PE, 12000rpm, centrifugal 1min.

Use new centrifuge tube instead, 12000rpm, centrifugal 1min.Eventually with 120ul EB wash-out probe.Probe changes enzyme plate over to carry out quantitatively measuring the light absorption value at 550nm and 650nm wavelength place respectively.Each probe that takes out 30pmolCy3 and Cy5 mark is hybridized.Drain at Speed Vac and to carry out probe in the instrument and drain.Probe is resuspended among the 9 μ l ddH2O 95 ℃ of sex change 5min.Add 11 μ g salmon sperm DNAs, hatch 45min at 45 ℃.Add 10 μ l 4 * Buffer and 20 μ l methane amides, mixture is tiled on the chip.Chip level is put into hybridizing box or the wet box that is added with PBS, put in 65 ℃ of hybridization casees lucifuge hybridization 6 hours.Chip is taken out, wash 10min respectively in 50 ℃ of washing lotion I and washing lotion II, each is 2 times.Finally at room temperature wash 5min among the washing lotion III, 2 times.The centrifugal 5min of 1500rpm, lucifuge is to be scanned.

4. data reads, handles and analyze

The Agilent scanner is adopted in the scanning of chip, and interpreting blueprints software is Imagene 5.1.The mark method of chip data adopts the default value markization method among the Standford Microarray Database.Obtain the ratio value of Cy3/Cy5 by the data after the stdn.The cut-off value of ratio value is set at 0.5, thinks feminine gender less than 0.5, more than or equal to 0.5 positive, during data analysis respectively with 0 and 1 expression.The large sample that is used to study usefulness detects and can also carry out cluster analysis.

Table 3 has shown the result who obtains with this chip detection 27 routine clinical helicobacter pyloris, wherein, the first line display clinical strains, the relevant gene information of probe of gene chip is shown in first tabulation.

Table 3

Gene_ID HP011-11 HP017-19 HP022-24 HP029-31 HP033-33 HP037-38 HP04-6 HP0521 HP0522 HP0523 HP0524 HP0526 HP0527-1 HP0527-2

HP_3F 1.050258 1.177595 1.134061 1.26956 1.106308 1.177595 1.233645 0.723753 0.934621 0.912037 1.524778 0.688926 1.015975 0.94496

HP_18D 1.068824 1.058497 1.142144 0.951098 0.92683 1.024419 0.909791 0.354726 0.960909 0.751791 1.664164 1.141628 0.888879 1.002474

HP_113A 0.868656 0.939252 0.941122 1.144026 1.029951 1.084651 1.532537 0.269293 1.204337 0.345499 1.181896 0.682582 1.027613 0.943459

HP_134M 1.100756 0.943065 1.031767 1.385955 1.292326 0.672034 1.716736 0.420714 1.417062 0.575941 1.198081 0.942449 1.248899 1.531018

HP_142 0.975051 1.247454 0.925153 1.002546 1.273422 1.156823 1.244908 0.443992 0.867617 0.636965 1.769348 0.555499 1.023931 0.861762

HP_143A 1.256561 1.23246 1.544135 1.270255 1.097163 1.109762 1.851429 0.678127 1.269982 0.79973 1.67505 1.03691 1.130303 1.177958

HP_222A 0.960887 1.126811 1.304286 1.22185 1.274882 1.198746 1.237602 0.353375 0.928333 0.711477 1.866117 0.767135 1.094519 1.054876

HP0528 HP0529 HP0530 HP0531 HP0532 HP0534 HP0535 HP0537 HP0538 HP0539 HP0540 HP0541 HP0542 HP0543 HP0544-1 HP0544-2 HP0545 HP0546 HP0547-1 HP0547-2 HP0547-3 HP0547-4 OL0520 OL0521 OL0522 OL0523 OL0527 OL0528 OL0535 OL0536 OL0537 OL0538 OL0542 OL0545 OL0546 OL0547

1.022777 1.104675 1.13134 1.063862 1.177051 1.160725 0.992575 0.921832 1.0323 0.933804 1.037742 0.950674 1.252691 1.223305 1.218408 1.155828 0.969992 0.974073 1.277995 0.961557 0.574649 0.696544 1.367512 0.725385 1.466007 1.517704 0.864694 1.162358 0.446768 0.56703 0.798305 1.366968 0.992031 1.285341 0.949041 0.782524

1.150664 0.81117 0.76883 0.942837 1.109615 0.972785 0.747144 0.909275 1.05385 0.741981 0.857124 0.895334 1.059013 0.858673 0.921151 1.030098 1.073213 0.687765 1.590585 1.18216 0.411007 0.534928 1.416321 1.20617 1.166928 1.669844 1.433876 1.036811 1.421484 1.647125 1.706504 1.451948 1.397216 1.061595 1.255223 0.754889

0.995822 1.297374 1.129066 1.194519 1.051925 1.06408 0.36607 0.957485 1.123222 1.5849 1.200596 0.890629 0.902317 1.055665 1.040236 0.885019 0.885019 0.832657 1.61412 1.252959 0.297344 0.455834 2.195483 0.335213 1.303919 1.828479 2.500308 0.951407 0.671362 2.265612 1.563861 1.777519 1.701313 1.902347 1.146831 0.767204

0.930438 1.137099 0.706529 0.950457 0.914114 1.116772 0.527279 1.412134 1.496215 0.763199 1.039158 0.934442 0.797694 1.620643 1.22888 0.950149 1.17991 0.922738 1.889519 1.038542 0.8519 0.503872 1.623107 0.607356 0.93013 1.212249 1.557197 1.220872 0.465065 0.907339 1.486976 2.197201 1.673618 1.10938 1.878123 0.546374

1.263748 1.084521 1.050917 1.12831 1.150713 0.928208 0.482688 0.685845 1.043279 0.964868 0.870672 0.831466 0.97556 1.022403 1.033096 0.914206 0.983198 0.603361 1.831467 0.903004 0.300917 0.300917 1.94501 0.992872 2.135438 1.829939 2.182281 0.866599 1.455703 1.858452 1.604379 2.960794 1.386456 1.440937 0.974033 0.696538

1.290249 1.470736 1.476213 1.480595 1.427463 1.614796 0.804659 1.255192 1.343929 1.462519 1.094972 1.282306 1.172754 1.24232 1.15906 1.244785 1.096616 1.060463 1.760775 1.814729 0.476003 0.619517 0.901613 0.25197 0.817806 0.735094 0.527493 1.191926 0.257447 0.257995 0.538996 0.790965 0.353853 0.508869 0.48422 0.718661

1.187195 1.19087 1.002368 1.159891 1.174068 1.29431 0.715152 0.98189 1.06984 1.038073 0.824893 1.068003 1.110009 1.200321 1.109483 0.999218 1.010769 0.879501 1.24469 1.1402 0.49147 0.633766 1.246003 0.687848 0.898928 1.333691 1.256504 1.2229 0.692049 0.958787 1.139413 1.348393 1.020746 0.989241 0.875825 0.819642

Gene_ID HP011-11 HP017-19 HP022-24 HP029-31 HP033-33 HP037-38 HP04-6 HP0521 HP0522 HP0523 HP0524 HP0526 HP0527-1 HP0527-2 HP0528 HP0529 HP0530 HP0531 HP0532 HP0534 HP0535 HP0537 HP0538 HP0539 HP0540 HP0541 HP0542 HP0543 HP0544-1 HP0544-2 HP0545 HP0546 HP0547-1 HP0547-2 HP0547-3 HP0547-4 OL0520 OL0521 OL0522 OL0523 OL0527 OL0528

HP_148N 1.059918375 0.963693375 1.075314375 1.134973875 1.123426875 1.0680975 1.3606215 0.175610625 1.189822125 0.411361875 1.210991625 1.102257375 1.127035313 1.060158938 1.245392063 1.073871 0.979089375 1.236010125 1.174426125 1.062324 0.574944375 1.094559375 1.21147275 1.093597125 1.125351375 1.11139875 0.98245725 1.16913375 1.093597125 1.127997563 1.041876188 1.381309875 1.735658438 1.312749563 0.400296 0.45129525 1.219651875 0.136158375 1.12679475 1.088785875 1.420762125 0.972353625

HP_155A 0.9395 1.0145 1.15 1.0645 1.017 1.111 1.3125 0.347 1.05125 0.4935 1.1675 0.9175 1.10725 1.01425 1.11475 1.067 0.967 1.2285 1.1085 1.2075 0.455 1.21225 1.11825 1.0295 1.0615 0.9575 0.9625 1.1125 1.0685 0.9225 0.948 1.0205 1.31975 1.02 0.295 0.546 1.146 0.31 1.1025 0.7795 1.3365 0.896

HP_156M 0.98862 1.05848 1.066419 1.186027 1.368615 1.372849 1.28817 0.197936 1.372849 0.308018 1.308811 0.915585 1.090499 0.977242 1.291346 1.097115 0.754696 1.067477 0.982269 1.729027 0.388462 1.195553 1.291346 1.184968 0.992854 0.968509 0.873775 2.134954 1.667635 0.932521 1.159036 0.869012 2.168561 1.529768 0.30643 0.637205 1.813176 0.202699 1.69886 0.881185 1.628471 0.881185

HP_161B 1.185844 1.09102 1.39511 1.289387 1.236526 1.136797 1.71882 0.140601 1.206008 0.406544 1.646884 0.633794 0.960228 0.949057 1.082573 1.17222 1.125353 1.468136 1.459416 1.401105 0.346053 1.080121 0.96595 1.589663 1.464866 1.167315 0.930255 1.378216 1.421269 0.840881 0.78148 0.674667 1.066497 1.455874 0.297551 0.565129 2.941176 0.221801 1.754787 1.890484 2.558066 1.16132

HP_173A 0.850316 1.105797 1.057239 1.046203 1.183048 1.070482 1.41701 0.298521 0.849488 0.595387 1.694562 1.051169 1.218363 1.121799 1.229123 1.22333 0.934189 1.329274 0.946328 0.987161 0.578281 1.113246 1.234641 1.01751 0.945225 0.810587 0.908806 0.997645 1.100279 0.886459 1.040409 1.1836 1.198499 0.884803 0.885631 0.624632 1.407629 0.590972 1.164839 1.174772 1.110212 1.063309

HP_197A 0.861731 1.011597 1.106276 1.052608 1.262218 1.136148 1.270826 0.156448 0.970587 0.535164 1.239435 0.816164 1.11539 1.049317 1.347024 1.065772 0.868819 1.193867 1.225764 1.029824 0.398462 0.986535 1.100707 0.975143 0.913881 0.870338 1.010585 1.289559 1.205512 0.804772 0.910336 0.908817 1.335633 1.229815 0.363527 0.482002 2.031802 0.380741 1.697134 1.467778 2.288499 1.007041

HP_923 1.333366 1.391605 1.518592 1.420505 1.312347 1.475241 1.617117 0.465912 1.249073 0.745284 1.526474 0.827606 1.163466 1.232433 1.665941 1.410434 1.393794 1.551872 1.685427 1.531291 0.689672 1.333804 1.519687 1.312347 1.225208 1.220391 1.457726 1.321543 1.225208 1.03407 1.32001 1.442838 1.665284 1.647988 0.304769 0.422561 1.159087 0.245217 0.476421 0.703684 0.875336 1.155584

OL0535 OL0536 OL0537 OL0538 OL0542 OL0545 OL0546 OL0547

0.437342625 1.150369875 1.184048625 1.966839 0.9757215 1.2297555 1.593967125 1.06136175

0.2325 0.805 1.0055 1.066 1.022 1.159 0.9015 0.784

0.106906 1.252711 0.783804 1.690922 0.925641 1.405132 1.112462 0.982799

0.566764 2.79567 2.424549 1.915552 1.665413 2.141712 1.541706 1.271948

0.95295 0.886183 1.150493 1.348587 1.35245 1.25423 0.691399 0.752648

0.577188 1.419173 1.571571 1.617644 1.643972 1.764979 1.680933 0.855655

0.035907 0.099838 0.542542 0.277182 0.437887 0.343303 0.687045 0.780753

Gene_ID HP011-11 HP017-19 HP022-24 HP029-31 HP033-33 HP037-38 HP04-6 HP0521 HP0522 HP0523 HP0524 HP0526 HP0527-1 HP0527-2 HP0528 HP0529 HP0530 HP0531 HP0532 HP0534 HP0535 HP0537 HP0538 HP0539 HP0540 HP0541 HP0542 HP0543 HP0544-1 HP0544-2 HP0545 HP0546 HP0547-1 HP0547-2

HP_233 0.995459 1.007544 1.473803 1.324761 1.183776 1.313684 1.682764 0.291538 1.417661 0.407851 1.579039 0.949135 1.270884 1.128137 1.199385 1.21449 1.06998 1.581053 1.314187 1.253261 0.422957 1.222295 1.365798 1.322747 1.392233 1.206937 1.089617 1.256786 1.222547 1.265598 1.362777 1.192839 1.914887 1.647517

HP_238 1.0225578 1.1320311 1.1557665 1.3616343 1.1092646 1.1194368 1.704586 0.2426819 1.2240662 0.5275062 1.7583539 0.9387575 1.0402383 0.9867126 1.0954593 1.0918263 0.9106626 1.2957566 1.0806852 1.0879512 0.5725549 1.0894044 1.062036 1.2715369 1.2550674 0.9750871 0.9484454 1.1790174 1.1431722 0.9508674 0.9508674 1.0162607 1.7905661 1.9705189

HP_503A 1.17799 1.069154 1.218537 1.272955 1.049414 1.11877 1.717902 0.216605 1.234542 0.557518 1.311368 0.917104 1.135843 0.954983 1.02594 1.292695 1.031808 1.513034 1.2068 1.062218 0.494564 1.066486 1.163852 1.135309 1.271354 1.093696 1.006733 1.164652 1.141178 1.110501 0.878691 1.234009 1.294562 1.208133

HP_813F 1.091462 0.998136 1.144363 1.184288 1.224214 1.19427 1.691841 0.259515 1.470254 0.508051 1.321033 0.92627 1.121905 0.944985 1.037313 1.192273 1.173808 1.09795 1.14586 1.421845 0.907306 1.118162 1.041804 1.209741 1.151849 1.197763 1.110426 1.426336 1.205748 1.07649 1.011361 1.014605 1.379174 1.533137

HP_816D 1.289018 1.356289 1.50532 1.264179 1.173622 1.060814 1.482034 0.687718 1.220194 0.766891 1.171035 1.168965 1.155511 1.246326 1.238823 1.641932 1.405449 1.719553 1.539991 1.617094 0.828987 1.225886 1.447364 1.59536 1.071163 1.226404 1.263144 1.187594 1.226921 1.411399 1.045289 1.041667 2.288511 2.020462

HP_824 0.597813 0.95862 1.090611 0.897442 0.900814 0.962474 0.82133 0.260128 1.015463 0.91671 0.958138 1.093501 1.031841 1.047015 1.245242 0.998121 0.826147 0.837227 0.84927 0.85216 0.667662 1.128666 1.080735 0.893588 0.675369 0.474974 0.704754 0.772195 0.94176 0.927067 0.942723 1.041475 1.645791 1.0988

HP_N170 0.993964 0.89485 1.107236 0.887771 1.104404 1.171895 1.258737 0.437042 1.017798 0.648955 1.733537 1.08175 0.936148 0.829483 1.034317 1.068534 0.962814 1.144521 0.945351 1.001515 0.613086 1.077974 1.091425 0.882579 1.006707 0.971781 0.969421 0.956206 1.100628 1.053431 1.259681 1.324341 1.520679 1.340388

HP0547-3 HP0547-4 OL0520 OL0521 OL0522 OL0523 OL0527 OL0528 OL0535 OL0536 OL0537 OL0538 OL0542 OL0545 OL0546 OL0547

0.177743 0.4149 1.192839 0.197883 0.865047 0.87109 1.134431 1.024663 0.14451 0.640981 0.837354 0.978843 0.984382 0.757294 0.864544 0.720537

0.405923 0.4708319 1.3916668 0.27223 1.1518913 1.1843458 1.2182534 0.8331594 0.389938 1.1610948 0.9116314 1.6924761 0.9300384 1.2700837 0.8418785 0.6917161

0.304101 0.449749 1.72217 0.287028 1.407933 1.302298 1.567986 1.023806 0.4012 0.970455 1.213735 0.795997 1.607999 1.824604 0.868021 1.027007

0.38029 0.447664 1.147357 0.192141 0.855403 0.893332 1.339998 1.090963 0.775552 1.166322 1.024088 1.098948 1.156341 1.156341 1.011112 0.850412

0.379823 0.495219 0.642698 0.606475 0.574392 0.843476 0.754471 1.24969 0.203366 0.456409 0.47866 0.529372 0.490562 0.432605 0.668571 0.807771

0.422467 0.625752 2.858518 1.180692 1.944216 2.107518 2.7694 0.550123 1.452863 1.469241 2.23132 1.096873 2.221686 1.954814 1.108916 0.49906

0.589015 0.69332 1.731177 1.101572 1.160568 1.169535 0.829719 0.641404 0.990188 0.807064 0.938743 0.882107 1.479146 1.310654 0.488958 0.569665

Gene_ID HP011-11 HP017-19 HP022-24 HP029-31 HP033-33 HP037-38 HP04-6 HP0521 HP0522 HP0523 HP0524 HP0526 HP0527-1 HP0527-2 HP0528 HP0529 HP0530 HP0531 HP0532 HP0534 HP0535 HP0537 HP0538 HP0539 HP0540 HP0541

HP_1229 0.914704 0.943876 1.080329 1.051156 1.073271 1.141027 1.10809 0.559456 0.936818 0.851182 1.449692 1.130675 1.114913 0.98787 1.09468 1.079388 0.993752 1.142909 1.059155 1.163142 0.76884 0.963874 1.21584 0.854476 0.933995 0.863416

HP_1231 1.06471468 1.06312 1.182721 1.28478052 1.1667742 1.19707312 1.5043148 0.22272364 1.27787024 0.41142744 1.45753752 0.91747256 1.15029584 0.95733956 1.09209002 1.05886752 0.82817048 1.29647484 1.19654156 1.11787068 0.46352032 1.24890022 1.16438218 1.1933522 1.23800324 1.14923272

HP_700392 1.07752896 1.07010504 1.05472692 1.0711656 1.0393488 0.99480528 1.05472692 0.941247 1.0181376 0.96033708 0.98685108 1.00965312 0.97385922 1.05340122 1.08336204 0.9783666 1.01124396 0.9094302 1.11464856 1.08124092 1.0101834 1.07355186 0.97889688 1.02980376 1.09078596 1.06374168

HP_AuA 0.98362 1.158829 1.118355 1.163089 1.129006 1.224865 1.446406 0.425507 1.048058 0.749298 1.757948 1.03794 1.12874 1.058976 1.157497 0.982022 1.116757 1.188119 1.132734 1.114095 0.683262 1.093591 1.166018 0.880838 1.024626 1.027822

HP_G3E 1.016822 1.153886 1.340356 1.392419 1.396669 1.378607 1..638922 0.146626 1.248449 0.397379 1.61289 1.053479 1.204621 0.946431 1.146448 1.143792 1.017885 1.518858 1.23623 1.214449 0.333097 1.219761 1.214715 1.112979 1.20223 1.129979

HP_N144 0.99503 1.338199 1.185444 1.314331 0.990257 1.158924 1.515883 0.420607 0.967184 0.655574 1.804951 0.793478 0.824507 0.867204 1.043827 1.283568 1.187035 1.346155 1.178549 1.165289 0.966389 0.668569 0.906719 1.205599 1.010412 0.855005

HP0542 HP0543 HP0544-1 HP0544-2 HP0545 HP0546 HP0547-1 HP0547-2 HP0547-3 HP0547-4 OL0520 0L0521 OL0522 OL0523 OL0527 OL0528 OL0535 OL0536 OL0537 OL0538 OL0542 OL0545 OL0546 OL0547

0.983871 1.034217 1.098209 1.004104 1.045745 0.861063 1.217958 1.300535 0.504404 0.537341 1.434165 0.778251 1.50992 1.230427 1.022454 1.066684 0.79566 0.552869 1.057744 1.173964 1.093033 1.272774 0.909528 0.914704

1.05089412 1.32198972 1.20610964 0.97089434 1.03441576 0.97381792 2.22564172 1.67733758 0.27534808 0.45235756 1.3289 0.21740804 0.88345272 1.17155824 1.7754104 1.0073062 0.41833772 1.22205644 1.17315292 1.43999604 1.22896672 1.40119216 1.19175752 0.8451804

1.14222312 1.06002972 1.0552572 0.94628466 1.0406745 1.0844226 1.09396764 1.02980376 0.93435336 1.07063532 0.5753538 0.90094572 1.06374168 0.58383828 1.05737832 1.08071064 0.73390752 0.84738744 0.70686324 0.99003276 0.84738744 1.29494376 0.9438984 0.56368764

1.064567 1.251493 1.19877 1.363861 1.229924 0.937288 1.889754 1.080278 0.4532 0.622018 0.647581 0.618823 0.833973 0.888293 0.880838 0.879773 0.726931 0.905868 0.835038 1.381435 1.154568 0.676339 1.005987 0.735984

1.005134 1.318575 1.242074 1.165042 1.35231 1.131573 1.732954 1.418982 0.329909 0.408535 1.445545 0.138126 1.54489 1.095448 1.574109 0.930228 0.175845 1.431201 1.235699 0.971665 1.080573 1.513014 1.030635 0.862227

0.974875 1.204538 1.069817 0.872508 0.783666 0.526687 1.11331 1.391504 0.489029 0.507593 1.202417 0.908045 1.192339 1.69728 1.275612 1.179079 1.252805 1.337138 1.682429 1.247501 1.489363 1.290994 0.677851 1.49838

＜110〉Shanghai Second Medicine University subsidiary Renji Hospital Xiao Shu east, Chen Shengliang

＜120〉helicobacter pylori pathogenicity island disease gene detection chip

<160>34

<170>PATENTIN?VERSION?3.1

<210>1

<211>345

<212>DNA

<213>HELICOBACTER?PYLORI

<220>

<221>GENE

<222>(1)..(348)

<223>

<400>1

ATGGCTGACA?CAATCAATAC?AACTGAAGCA?ACTCATGAAA?CAAAAAAACC?AAACGCTTTT 60

GTAAATTTTT?TCAAAAACAA?TTTGACTGAT?AAGCGTTATG?ATTCATTAGG?TCTCATTGGA 120

GCAGGGGTTT?TATGTTGTGT?CTTGAGCGGT?GCTATGGGGA?TTGTTGGGAT?AATCTTTGTC 180

GCAATAGGAA?TCTTTTTGTC?TTTTTCTAAT?ATCAACTTAG?TGAAATTAGT?TGAAAAATTG 240

TCCAAAAAAC?AATCTAAAGT?GCCAACAACT?GTCAATAACG?AAACTCAAAA?ATCTCAAGCA 300

ACAAGCGTTA?CCAACGAACC?AACTGAAGCC?AAAGAGACTA?AAGATTGA 348

<210>2

<211>243

<212>DNA

<213>HELICOBACTER?PYLORI

<400>2

ATGATACAAA?GAGGATTGAG?TAGTGTCTCA?TTTTATTATG?GTTGCTCTAA?TTATGTAAAT 60

AAAGGCGGCT?GTAAGGGCGT?TTTACGAGAA?ATAAATGGCT?CAATGAAAAT?GGTTTGCTTG 120

GCTAGTATAA?AAGCTAATAT?TAAAGAAAAT?TCTTTTTTCT?TGGGGTGTAA?AATTATCTTA 180

AGTGTAAATG?GACTGCTAGT?GTGGATTCAC?AAAATCCTAA?ATATCCCAAA?TGCAATGGAT 240

TGA 243

<210>3

<211>1446

<212>DNA

<213>HELICOBACTER?PYLORI

<400>3

ATGTTTAGAA?AACTAGCAAC?CGCTGTATCG?CTCATAGGCT?TACTAACCTC?TAACACTCTT 60

TATGCTAAAG?AAATAAGTGA?AGCCGATAAG?GTCATTAAGG?CCACTAAAGA?AACTAAAGAG 120

ACCAAGAAAG?AAGCTAAACG?ACTCAAAAAA?GAAGCTAAAC?AGCGCCAACA?GATCCCTGAT 180

CATAAGAAAC?CTCAATATGT?CTCTGTTGAT?GACACAAAAA?CTCAAGCGCT?GTTTGATATA 240

TACGACACCT?TGAATGTGAA?TGACAAAAGC?TTTGGGGATT?GGTTTGGTAA?TAGCGCTTTG 300

AAAGACAAAA?CCTATCTCTA?CGCTATGGAT?CTATTGGATT?ACAACAACTA?TTTATCCATA 360

GAAAACCCCA?TTATCAAAAC?AAGAGCAATG?GGAACTTATG?CGGATTTGAT?TATCATCACA 420

GGCTCATTAG?AGCAAGTCAA?TGGGTATTAC?AACATTCTAA?AAGCGCTCAA?CAAACGCAAC 480

GCTAAGTTTG?TGTTAAAAAT?CAATGAGAAC?ATGCCTTATG?CCCAAGCGAC?TTTTTTAAGA 540

GTGCCAAAAA?GAAGCGATCC?TAATGCCCAC?ACGCTTGATA?AGGGAGCGTC?AATTGATGAG 600

AATAAGCTTT?TTGAACAACA?AAAGAAAATG?TATTTCAATT?ACGCTAACGA?TGTGATCTGC 660

AGACCCGATG?ATGAAGTGTG?TTCGCCCCTA?AGAGATGAGA?TGGTAGCTAT?GCCCACTAGC 720

GATAGCGTTA?CTCAAAAACC?CAATATCATT?GCTCCTTATA?GCTTGTATAG?ACTAAAAGAG 780

ACAAATAACG?CCAATGAGGC?CCAACCATCA?CCTTATGCCA?CTCAAACCGC?TCCCGAAAAC 840

AGCAAAGAGA?AGCTCATAGA?AGAGCTAATC?GCTAACTCCC?AACTCGTAGC?CAATGAAGAA 900

GAGAGGGAAA?AGAAACTCTT?AGCAGAAAAA?GAAAAACAAG?AGGCTGAATT?GGCTAAATAT 960

AAGCTCAAAG?ACTTAGAAAA?TCAAAAGAAA?CTAAAAGCTT?TAGAAGCAGA?GTTGAAAAAG 1020

AAAAACGCTA?AGAAACCTAG?AGTAGTGGAA?GTGCCTGTTT?CTCCTCAAAC?AAGTAATTCT 1080

GATGAAACAA?TGAGAGTTGT?CAAAGAAAAA?GAGAACTATA?ATGGGTTATT?AGTGGATAAG 1140

GAGACCACGA?TCAAAAGAAG?CTATGAGGGG?ACTTTGATCA?GTGAAAATTC?TTACAGCAAA 1200

AAAACACCTC?TCAACCCTAA?TGACTTGAGG?AGCTTAGAAG?AAGAAATTAA?GAGCTACTAT 1260

ATCAAGTCTA?ATGGCTTGTG?TTATACTAAT?GGCATTAACC?TCTATGTAAA?AATCAAAAAC 1320

GACCCCTATA?AAGAGGGAAT?GCTGTGTGGT?TATGAGAGCG?TTCAAAATCT?GCTCTCACCT 1380

CTAAAGGACA?AGCTCAAATA?CGACAAACAA?AAGTTACAAA?AAGCGTTACT?GAAAGATTCA 1440

AAGTAA 1446

<210>4

<211>510

<212>DNA

<213>HELICOBACTER?PYLORI

<400>4

TTGTTCGAGA?AATGGATTGG?TCTGACTTTG?CTTCTTAATT?CCTTAGCCTA?TCCATGCCAA 60

AAGGTAACCA?TTAGTTTCAA?GCAGTATGAA?AATCTTCTCC?ATATCCATCA?AAAAGGTTGC 120

GACAATGAAG?TGATGTGCAG?AACGCTCATC?TCTATCGCTT?TGTTAGAAAG?CTCTCTAGGG 180

TTGAACAACA?GGCGAGAAAA?ATCCCTTAAA?GACACTTCTT?ATTCCATGTT?TCATATCACC 240

CTAAACACCG?CTAAAAAATT?CTACCCTACC?TACTCTAAAA?CGCTCCTCAA?ATTCAAATTG 300

CTAAACGATG?TGGGTTTTGC?GATCCAATTA?GCCAAACAAA?TTTTAAAAGA?AAATTTTGAT 360

TATTACAAAC?AAAAACACCC?CAACAAAAGC?GTGTATCAAT?TAGTAGAAAT?GGCAATAGGC 420

GCTTACAATG?GGGGAATGAA?ACACAACCCT?AATGGCGCTT?ACGTGAAAAA?ATTCCGTTGC 480

ATTTATTCTC?AAGTGCGATA?TAACGAGTAG 510

<210>5

<211>2247

<212>DNA

<213>HELICOBACTER?PYLORI

<400>5

ATGGAAGACT?TTTTGTATAA?CACCTTATAT?TTCATAGAGG?ATTATAAGTT?GGTTGTTATT 60

TTTAGTTTCA?TAGGGTTAAT?AGCGTTATTT?TTTCTTTACA?AATTCATAAA?AGCTCAAAAA 120

AAGGCTTTTA?AAGATAAAGC?TAACCAGCCT?CAAAAGAAAA?AAAGCTTTAA?AGAAATCATT 180

ATAGATGGGC?TGAAAGAAAG?GGTTAAAACC?TTTGGCTTTT?GGTTGCAAGC?TATACTATTA 240

CTATCCTATT?CTTTTATCAC?ATCAGGATTA?TTTTTCTTGA?TTCTCTTAGG?TAATTTTTAT 300

GATGATAATC?GATCGCCTGA?GAGCGATGAT?GATCTTTTTG?ATATATGGAT?CTATGCGATA 360

CAAGATTTTC?CTAATTACTA?TTTTAAAGCG?CTTGGTTTTA?GTTCACTCAA?GATTTATGGG 420

TTCAATATAT?CCTTAGTCGT?ATATGGTTCT?ATTTTATGCT?CTTATATCTT?CATTACCTTT 480

TTTGTGTGGT?TCTTAAAATA?CTTAACTCGG?ACTAGAGATA?TAGGAGCGAA?TAAAAAAGTT 540

GATGATCTCT?TTGGTAGCGC?GAGTTGGGAA?ACTGAAGAGA?AAATGATCAA?AGCCAAACTC 600

ATCACGCCCA?ACAATAAAAA?ACGCGCCTTT?GACAAACGAG?AGGTGATTGT?AGGCAGGCGT 660

GGCTTGGGGG?ATTTTATCGC?TTACGCAGGG?CAGGCGTTCA?TTGGCTTGAT?TGCTCCTACT 720

AGAAGCGGTA?AGGGGGTGGG?TTTCATCATG?CCCAATATGA?TCAATTATCC?TCAAAATATC 780

GTTGTGTTTG?ACCCTAAAGC?TGACACTATG?GAGACTTGCG?GAAAAATCAG?AGAAAAACGC 840

TTCAACCAAA?AAGTGTTCAT?CTATGAACCT?TTCTCCTTAA?AAACACACCG?ATTTAATCCT 900

TTCGCTTATG?TGGATTTTGG?TAATGATGTG?GTTTTGACCG?AAGACATACT?CTCTCAAATT 960

GACACACGCC?TAAAAGGGCA?TGGCATGGTG?GCTAGTGGAG?GGGATTTTTC?CACTCAAATC 1020

TTTGGATTAG?CAAAGCTCGT?GTTCCCTGAA?AGACCTAATG?AAAAAGATCC?TTTCTTTAGC 1080

AATCAAGCGC?GAAATCTTTT?TGTCATCAAT?TGCAATATTT?ACAGGGATCT?CATGTGGACT 1140

AAAAAGGGGC?TTGAGTTTGT?CAAAAGAAAA?AAAATCATCA?TGCCTGAAAC?ACCCACGATG 1200

TTTTTCATAG?GTTCTATGGC?AAGCGGGATC?AACTTGATTG?ATGAAGACAC?AAACATGGAA 1260

AAAGTCGTGT?CTTTAATGGA?ATTTTTTGGA?GGTGAAGAAG?ATAAGAGTGG?CGATAATCTA 1320

AGAGTGCTTA?GTCCTGCCAC?TAGAAACATG?TGGAATAGCT?TCAAGACAAT?GGGCGGCGCT 1380

AGAGAAACTT?ATAGCTCGGT?TCAAGGGGTA?TACACTTCAG?CCTTTGCGCC?TTATAATAAC 1440

GCAATGATTA?GAAATTTCAC?GAGCGCCAAT?GATTTTGATT?TCAGGCGTTT?AAGGATCGAT 1500

GAAGTGAGTA?TTGGTGTGAT?CGCTAATCCT?AAAGAAAGCA?CTATTGTTGG?ACCGATATTA 1560

GAGCTGTTTT?TCAATGTGAT?GATTTATAGC?AATTTGATTC?TGCCAATCCA?TGATCCACAG 1620

TGCAAAAGAA?GTTGCTTGAT?GCTCATGGAC?GAATTCACTT?TATGTGGCTA?TTTAGAGACC 1680

TTTGTTAAAG?CGGTAGGGAT?TATGGCAGAA?TACAACATGC?GCCCCGCTTT?TGTGTTTCAA 1740

AGTAAGGCGC?AACTAGAGAA?TGACCCCCCA?CTTGGTTATG?GTAGGAATGG?CGCTAAGACT 1800

ATTTTAGACA?ACCTTTCTTT?GAATATGTAT?TATGGGATTA?ACAACGATAA?CTACTATGAA 1860

CATTTTGAAA?AACTTTCTAA?GGTATTAGGG?AAATACACAA?GGCAAGACGT?GAGCCGAAGC 1920

ATTGATGATA?ATACAGGTAA?GACCAACACT?TCTATCAGCA?ACAAAGAGCG?GTTTTTGATG 1980

ACCCCTGATG?AATTGATGAC?TATGGGCGAT?GAGCTTATCA?TTCTAGAGAA?TACGCTCAAA 2040

CCTATCAAGT?GCCACAAGGC?GCTTTACTAT?GATGATCCAT?TCTTCACCGA?TGAACTCATT 2100

AAGGTAAGTC?CAAGCTTGAG?CAAGAAATAC?AAATTGGGGA?AAGTGCCTAA?TCAAGCAACT 2160

TTCTATGATG?ATTTGCAAGC?CGCTAAAACT?AGAGGTGAAT?TGAGTTATGA?TAAATCTTTA 2220

GTGCCTGTGG?GTTCAAGTGA?ACTGTGA 2247

<210>6

<211>600

<212>DNA

<213>HELICOBACTER?PYLORI

<400>6

ATGGAACTCG?GTTTCAATGA?AGCAGAAAGA?CAAAAGATCT?TAGATAGCAA?CAGCTCTCTT 60

ATGGGAAATG?CAAATGAAGT?AAGGGATAAG?TTTATTCAAA?ATTACGCCTC?TTCTTTAAAA 120

GATAGCAACG?ATCCGCAAGA?TTTTTTGAGA?AGAGTTCAAG?AGTTAAGAAT?CAATATGCAA 180

AAGAATTTTA?TTAGTTTTGA?TGTTTATTAC?AACTATTTGA?ACAACCTTGT?GTTGGCCAGT 240

TACAATCGTT?GCAAACAAGA?AAAGACTTTT?GCAGAAAGCA?CGATCAAAAA?TGAACTAACG 300

CTTGGGGAGT?TTGTTGCAGA?AATTTCTGAC?AACTTCAATA?ATTTCATGTG?TGATGAAGTG 360

GCAAGAATTT?CAGACCTAGT?GGCTTCTTAT?CTGCCAAGAG?AGTATTTACC?GCCATTCATA 420

GATGGCAATA?TGATGGGCGT?GGCGTTTCAG?ATCCTAGGGA?TAGATGATTT?TGGAAGGAAG 480

CTCAATGAGA?TTGTCCAAGA?TATAGGGACT?AAATATATTA?TTTTGAGCAA?AAATAAGACT 540

TATCTCACTT?CTTTAGAAAG?AGCTAAATTG?ATAACCCAAT?TAAAATTAAA?TTTGGAATAA 600

<210>7

<211>5784

<212>DNA

<213>HELICOBACTER?PYLORI

<400>7

ATGAATGAAG?AAAACGATAA?ACTTGAAACT?TCTAAAAAAG?CCCAACAAGA?TTCACCCCAA 60

GATTTATCCA?ATGAAGAAGC?AACAGAAGCC?AATCATTTTG?AAAATCTTTT?AAAAGAATCC 120

AAAGAAAGCT?CAGATCATCA?TCTTGACAAC?CCCACAGAAA?CTCAAACCCA?TTTTGATGGA 180

GACAAGTCAG?AAGAAACCCA?AACTCAAATG?GATTCTGAAG?GTAATGAAAC?TTCAGAATCT 240

AGCAATGGCA?GTCTAGCAGA?CAAGTTATTC?AAAAAAGCCA?GAAAATTAGT?TGATAATAAA 300

AAACCTTTCA?CTCAGCAAAA?GAATTTAGAT?GAAGAAACCC?AAGAACTGAA?CGAAGAAGAC 360

GATCAAGAAA?ATAATGAGTA?TCAAGAAGAA?ACTCAAACGG?ACTTAATTGA?TGATGAAACT 420

TCTAAAAAAA?CCCAACAACA?TTCACCCCAA?GATTTATCCA?ATGAAGAAGC?AACAGAAGCC 480

AATCATTTTG?AAAATCTTTT?AAAAGAATCC?AAAGAAAGCT?CAGATCATCA?TCTTGACAAC 540

CCCACAGAAA?CTCAAACCAA?TTTTGATGGA?GACAAGTCAG?AAGAAACCCA?AACTCAAATG 600

GATTCTGAAG?GTAATGAAAC?TTCAGAATCT?AGCAATGGCA?GTCTAGCAGA?CAAGTTATTC 660

AAAAAAGCCA?GAAAATTAGT?TGATAATAAA?AAACCTTTCA?CTCAGCAAAA?GAATTTAGAT 720

GAAGAAACCC?AAGAACTGAA?CGAAGAAGAC?GATCAAGAAA?ATAATGAGTA?TCAAGAAGAA 780

ACTCAAACGG?ACTTAATTGA?TGATGAAACT?TCTAAAAAAA?CCCAACAACA?TTCACCCCAA 840

GATTTATCCA?ATGAAGAAGC?AACAGAAGCC?AATCATTTTG?AAAATCTTTT?AAAAGAATCC 900

AAAGAAAGCT?CAGATCATCA?TCTTGACAAC?CCCACAGAAA?CTCAAACCAA?TTTTGATGGA 960

GACAAGTCAG?AAGAAATAAC?TGACGACTCT?AACGATCAAG?AGATTATCAA?AGGAAGCAAA 1020

AAGAAATATA?TTATTGGTGG?CATTGTAGTC?GCTGTTCTTA?TCGTGATTAT?TTTATTTTCT 1080

AGAAGCATTT?TTCACTACTT?CATGCCTTTG?GAAGATAAAA?GCTCTCGTTT?TAGCAAAGAC 1140

AGGAATCTTT?ATGTCAATGA?TGAAATCCAA?ATAAGGCAAG?AGTATAACCG?ATTGCTGAAA 1200

GAACGGAATG?AAAAAGGCAA?TATGATCGAT?AAGAATCTTT?TCTTCAATGA?CGATCCCAAT 1260

AGAACCTTAT?ACAACTATTT?GAATATTGCA?GAAATTGAGG?ACAAAAACCC?GTTGAGAGCC 1320

TTTTATGAAT?GTATTAGTAA?TGGTGGCAAC?TATGAAGAAT?GTTTGAAGCT?TATCAAAGAC 1380

AAAAAACTTC?AAGATCAGAT?GAAAAAGACT?CTAGAGGCTT?ATAACGACTG?CATCAAAAAT 1440

GCCAAAACTG?AAGAAGAAAG?GATCAAGTGT?TTAGATTTAA?TCAAAGATGA?AAACCTAAAA 1500

AAAAGCTTAC?TGAACCAACA?AAAAGTTCAA?GTGGCGCTAG?ATTGTTTGAA?AAACGCTAAA 1560

ACCGATGAAG?AACGAAACGA?GTGCCTAAAA?CTCATAAATG?ACCCTGAGAT?TAGAGAGAAA 1620

TTCCGTAAGG?AATTAGAGCT?TCAAAAAGAG?CTTCAAGAGT?ATAAGGATTG?TATCAAAAAC 1680

GCCAAAACAG?AAGCTGAGAA?AAACAAATGC?TTGAAAGGCT?TGTCTAAAGA?AGCTATAGAG 1740

AGATTGAAAC?AGCAAGCGCT?AGATTGTTTG?AAAAACGCTA?AAACCGATGA?AGAACGAAAC 1800

GAGTGCTTGA?AAAATATTCC?CCAAGACTTG?CAAAAAGAAC?TATTAGCTGA?TATGAGCGTC 1860

AAGGCTTACA?AGGATTGCGT?ATCAAAAGCT?AGAAATGAAA?AAGAGAAACA?AGAATGCGAG 1920

AAATTGCTCA?CGCCTGAAGC?GAGGAAAAAG?TTAGAACAAC?AGGTTCTAGA?TTGTTTGAAA 1980

AACGCTAAAA?CCGATGAAGA?ACGAAAAAAG?TGTTTGAAAG?ATCTCCCTAA?AGACTTACAA 2040

AGCGATATTC?TAGCCAAAGA?GAGCCTGAAA?GCTTATAAAG?ACTGCGTATC?TCAAGCCAAA 2100

ACCGAAGCTG?AGAAAAAAGA?ATGCGAGAAA?TTACTCACCC?CTGAAGCGAA?AAAACTTTTA 2160

GAAGAAGAAG?CCAAAGAGAG?CGTTAAGGCT?TATTTGGATT?GCGTATCTCA?AGCCAAAACC 2220

GAAGCTGAGA?AAAAAGAATG?CGAGAAATTG?CTCACCCCTG?AAGCGAAAAA?AAAGTTAGAA 2280

GAAGCTAAAA?AAAGCGTTAA?AGCTTACTTG?GATTGCGTAT?CAAGAGCTAG?GAATGAAAAA 2340

GAGAAAAAAG?AATGCGAGAA?ATTGCTCACC?CCTGAAGCGA?AAAAACTTTT?AGAGCAACAA 2400

GCACTAGATT?GTTTGAAAAA?CGCTAAAACC?GATAAAGAAC?GAAAAAAGTG?TTTGAAAGAT 2460

CTCCCTAAAG?ACTTGCAGAA?AAAGGTTTTA?GCTAAAGAAA?GCGTTAAAGC?TTACTTGGAT 2520

TGCGTATCTC?AAGCCAAAAC?TGAAGCTGAG?AAAAAAGAAT?GCGAGAAATT?ACTCACCCCT 2580

GAAGCGAGAA?AACTTTTAGA?AGAAGCTAAA?AAAAGCGTTA?AGGCTTATTT?GGATTGCGTA 2640

TCTCAAGCCA?AAACTGAAGC?TGAGAAAAAA?GAATGCGAGA?AATTACTCAC?CCCTGAAGCG 2700

AGAAAACTTT?TAGAAGAAGA?MGCCAAAGAG?AGCGTTAAAG?CTTACTTGGA?TTGCGTATCT 2760

CAAGCCAAAA?ACGAAGCTGA?GAAAAAAGAA?TGCGAGAAAT?TGCTCACCCT?TGAATCGAAA 2820

AAAAAGTTAG?AAGAAGCTAA?AAAAAGCGTT?AAGGCTTATT?TGGATTGCGT?ATCTCAAGCC 2880

AAAACCGAAG?CTGAGAAAAA?AGAATGCGAA?AAATTGCTCA?CGCCTGAAGC?GAAAAAACTT 2940

TTAGAGCAAC?AAGCGCTAGA?TTGTTTGAAA?AACGCTAAAA?CCGAAGCTGA?TAAAAAAAGG 3000

TGTGTCAAAG?ATCTCCCTAA?AGACTTGCAG?AAAAAGGTTT?TAGCCAAAGA?GAGCCTGAAA 3060

GCTTATAAAG?ACTGCGTATC?AAAAGCTAGG?AATGAAAAAG?AGAAAAAAGA?ATGCGAGAAA 3120

TTACTCACCC?CTGAAGCGAA?AAAACTTTTA?GAAGAAGCTA?AAAAAAGCGT?TAAGGCTTAC 3180

TTGGATTGCG?TATCTCAAGC?CAAAACTGAA?GCTGAGAAAA?AAGAATGCGA?GAAATTACTC 3240

ACCCCTGAAG?CGAGAAAACT?CTTAGAAGAA?GCTAAAGAGA?GCGTTAAAGC?TTATAAAGAC 3300

TGCGTATCAA?AAGCTAGGAA?TGAAAAAGAG?AAAAAAGAAT?GCGAGAAATT?ACTCACGCCT 3360

GAAGCGAAAA?AACTTTTAGA?GCAACAAGTG?CTAGATTGTT?TGAAAAACGC?TAAAACCGAA 3420

GCTGATAAAA?AAAGGTGTGT?CAAAGATCTC?CCTAAAGACT?TGCAGAAAAA?GGTTTTAGCT 3480

AAAGAGAGCG?TTAAGGCTTA?TTTGGACTGC?GTATCAAGAG?CTAGGAATGA?AAAAGAGAAA 3540

AAAGAATGCG?AGAAATTGCT?CACCCCTGAA?GCGAAAAAAC?TTTTAGAAGA?AGCCAAAGAG 3600

AGTCTTAAAG?CTTATAAAGA?CTGCCTCTCT?CAAGCTAGAA?ATGAAGAAGA?AAGGAGAGCT 3660

TGCGAGAAAC?TACTCACGCC?TGAAGCGAGA?AAACTCTTAG?AGCAAGAAGT?TAAGAAAAGC 3720

ATTAAGGCTT?ATTTGGACTG?CGTATCAAGA?GCTAGGAATG?AAAAAGAGAA?AAAAGAATGC 3780

GAGAAATTAC?TCACGCCTGA?AGCGAGAAAA?TTTTTAGCGA?AGCAAGTGCT?AAATTGTTTG 3840

GAAAAAGCTG?GAAATGAAGA?AGAAAGAAAA?GCATGTCTTA?AAAATCTCCC?TAAAGACTTA 3900

CAGGAAAATA?TTTTAGCTAA?AGAGAGTCTT?AAAGCTTATA?AAGACTGCCT?CTCTCAAGCT 3960

AGAAATGAAG?AAGAAAGGAG?AGCTTGCGAG?AAACTACTCA?CGCCTGAAGC?GAGAAAACTC 4020

TTAGAGCAAG?AAGTTAAGAA?AAGCGTTAAG?GCTTATTTGG?ACTGCGTATC?AAGAGCTAGG 4080

AATGAAAAAG?AGAAAAAAGA?ATGCGAGAAA?TTACTCACGC?CTGAAGCGAG?AAAATTTTTA 4140

GCGAAAGAAC?TCCAACAAAA?AGATAAAGCG?ATCAAAGATT?GCTTGAAAAA?CGCCGATCCT 4200

AACGACAGAG?CGGCTATCAT?GAAGTGTTTG?GATGGTTTGA?GCGATGAAGA?GAAGCTCAAA 4260

TACCTGCAAG?AAGCTAGAGA?AAAGGCTGTT?GCGGATTGTT?TGGCTATGGC?TAAAACCGAT 4320

GAAGAAAAAA?GGAAATGCCA?AAACCTTTAT?AGCGATTTGA?TCCAAGAAAT?CCAAAATAAA 4380

AGGACACAAA?ACAAACAAAA?TCAATTGAGT?AAAACAGAAA?GGTTGCATCA?AGCAAGCGAG 4440

TGCTTGGATA?ACTTAGATGA?CCCTACTGAT?CAAGAGGCCA?TAGAGCAATG?TTTAGAGGGC 4500

TTGAGCGATA?GTGAAAGGGC?GCTAATTCTA?GGAATTAAAC?GACAAGCTGA?TGAAGTGGAT 4560

CTGATTTATA?GCGATCTAAG?AAACCGTAAA?ACCTTTGATA?ACATGGCGGC?TAAAGGTTAT 4620

CCATTGTTAC?CAATGGATTT?CAAAAATGGC?GGCGATATTG?CCACTATTAA?CGCCACTAAT 4680

GTTGATGCGG?ACAAAATAGC?TAGCGATAAT?CCTATTTATG?CTTCCATAGA?GCCTGATATT 4740

GCCAAGCAAT?ACGAAACAGA?AAAAACCATT?AAGGATAAGA?ATTTAGAAGC?TAAATTAGCT 4800

AAGGCTTTAG?GTGGCAATAA?AAAAGATGAC?GATAAAGAAA?AAAGTAAAAA?ATCCACAGCA 4860

GAAGCTAAAG?CAGAAAACAA?TAAGATAGAC?AAAGATGTCG?CAGAAACTGC?CAAGAATATC 4920

AGTGAAATCG?CTCTTAAGAA?CAAAAAAGAA?AAGAGTGGGG?AATTTGTAGA?TGAAAATGGT 4980

AATCCCATTG?ATGACAAAAA?GAAAGCAGAA?AAACAAGATG?AAACAAGCCC?TGTCAAACAG 5040

GCCTTTATAG?GCAAGAGTGA?TCCCACATTT?GTTTTAGCGC?AATACACCCC?CATTGAAATC 5100

ACTCTGACTT?CTAAAGTAGA?TGCCACTCTC?ACAGGTATAG?TGAGTGGGGT?TGTAGCCAAA 5160

GATGTATGGA?ACATGAACGG?CACTATGATC?TTATTAGACA?AAGGCACTAA?GGTGTATGGG 5220

AATTATCAAA?GCGTGAAAGG?TGGCACACCC?ATTATGACAC?GCTTAATGAT?AGTCTTTACT 5280

AAAGCCATTA?CGCCTGATGG?TGTGATAATA?CCTCTAGCAA?ACGCTCAAGC?AGCAGGCATG 5340

TTGGGTGAAG?CAGGGGTAGA?TGGCTATGTG?AATAATCACT?TTATGAAGCG?CATAGGCTTT 5400

GCTGTGATAG?CAAGCGTGGT?TAATAGCTTC?TTGCAAACTG?CGCCTATCAT?AGCTCTAGAT 5460

AAACTCATAG?GCCTTGGCAA?AGGTAGAAGT?GAAAGGACAC?CTGAATTTAA?TTACGCTTTG 5520

GGTCAAGCTA?TCAATGGTAG?CATGCAAAGT?TCAGCTCAGA?TGTCTAATCA?AATTCTAGGG 5580

CAACTGATGA?ATATCCCCCC?AAGTTTTTAC?AAAAACGAGG?GCGATAGTAT?TAAGATTCTC 5640

ACAATGGACG?ATATTGATTT?TAGCGGTGTG?TATGATGTTA?AAATTACTAA?CAAATCTGTG 5700

GTAGATGAAA?TTATCAAACA?AAGCACCAAA?ACTTTGTCTA?GAGAACATGA?AGAAATCACC 5760

ACAAGCCCCA?AAGGTGGCAA?TTAA 5784

<210>8

<211>1569

<212>DNA

<213>HELICOBACTER?PYLORI

<400>8

ATGGGGCAGG?CATTTTTTAA?AAAAATTGTT?GGCTGTTTCT?GTCTTGGTTA?TTTATTTTTA 60

TCTAGCGCAA?TAGAAGCAGC?AGCACTTGAC?ATTAAGAATT?TTAATCGTGG?TAGGGTGAAA 120

GTGGTGAATA?AGAAGATTGC?TTATTTGGGA?GATGAAAAAC?CTATTACGAT?TTGGACTTCA 180

TTAGACAATG?TTACCGTGAT?CCAACTTGAA?AAAGATGAAA?CTATTTCTTA?CATCACAACA 240

GGTTTCAATA?AAGGTTGGAG?TATTGTGCCT?AATTCTAATC?ATATATTCAT?TCAACCTAAA 300

TCGGTAAAAA?GTAATCTCAT?GTTTGAAAAA?GAAGCAGTGA?ATTTTGCCCT?AATGACAAGA 360

GATTACCAAG?AATTTTTAAA?AACAAAAAAA?CTTATCGTAG?ATGCGCCTGA?CCCTAAAGAA 420

TTAGAAGAAC?AAAAAAAAGC?TCTAGAAAAA?GAAAAAGAAG?CTAAAGAACA?AGCGCAAAAA 480

GCACAAAAAG?ATAAAAGAGA?AAAAAGAAAA?GAAGAGCGTG?CAAAAAATAG?AGCCAATTTA 540

GAAAATCTCA?CTAACGCTAT?GAGTAACCCA?CAAAATTTGA?GCAATAACAA?AAATCTTAGC 600

GAATTTATCA?AGCAACAACG?AGAAAATGAA?TTAGACCAAA?TGGAACGACT?AGAGGACATG 660

CAAGAACAGG?CTCAAGCTAA?TGCGCTCAAA?CAAATTGAAG?AACTCAACAA?GAAACAAGCT 720

GAAGAGACAA?TCAAGCAAAG?AGCCAAAGAT?AAAATCAATA?TTAAGACAGA?TAAGCCTCAA 780

AAAAGCCCTG?AGGATAACTC?CATAGAATTA?TCTCCTAGCG?ATAGCGCTTG?GAGAACTAAT 840

CTTGTTGTGC?GGACTAATAA?AGCCTTGTAT?CAATTCATTT?TGAGAATAGC?TCAAAAAGAC 900

AATTTTGCTT?CAGCGTATCT?AACAGTCAAA?TTAGAATACC?CACAAAGACA?CGAAGTCTCT 960

AGCGTTATTG?AAGAGGAGTT?AAAAAAGAGA?GAAGAAGCAA?AGAGGCAGAA?AGAATTGATT 1020

AAGCAAGAAA?ATCTTAACAC?CACAGCCTAC?ATCAATAGAG?TGATGATGGC?GAGCAATGAA 1080

CAGATTATCA?ACAAAGAAAA?AATAAGAGAA?GAAAAGCAAA?AAATTATCTT?AGATCAAGCA 1140

AAGGCGCTAG?AGACTCAATA?TGTGCATAAT?GCCTTAAAAA?GAAACCCCGT?GCCTAGAAAC 1200

TACAACTACT?ACCAAGCGCC?TGAAAAACGC?TCTAAACATA?TTATGCCCTC?TGAAATTTTT 1260

GATGATGGCA?CATTCACTTA?TTTTGGTTTC?AAAAACATCA?CTCTCCAACC?TGCTATTTTT 1320

GTGGTTCAAC?CTGATGGGAA?ATTGAGCATG?ACTGATGCCG?CCATTGATCC?TAACATGACC 1380

AATTCAGGAT?TGAGATGGTA?TAGAGTTAAT?GAAATTGCAG?AAAAATTTAA?GCTCATTAAA 1440

GACAAAGCCC?TTGTAACAGT?AATCAATAAA?GGCTATGGGA?AAAATCCATT?GACAAAAAAT 1500

TACAATATCA?AAAACTATGG?TGAATTGGAG?CGTGTGATTA?AAAAGCTCCC?TCTTGTCAGA 1560

GATAAATAA 1569

<210>9

<211>1608

<212>DNA

<213>HELICOBACTER?PYLORI

<400>9

ATGTTTAATA?TTAAAAGGAA?TTTTTTAATA?ACGATCATAA?GTTTTTTTCT?CATTGTTCCT 60

AATTGGTTGA?AAGCTATTGA?TTTGCCCATT?GTTTCAAATC?TCAAAATTTA?CCAAACAGTT 120

TATTGCATGC?TGATACCGAG?TTATGTTTTA?ACCAACAAAA?GTTTTGCAGA?TATTTTAACA 180

GGCTATACAT?CTATTGGTGC?ATCAGGGAGT?GGAAAGAGTT?CAGGGCAGGG?TGTGATTGAA 240

GCGCTTAGCA?CACCATTAGC?CACAAGTTTA?GCCGCTAGCA?ATCTGGTGAA?ATATTTGAAT 300

ACTTTAGGTC?CTTTATGGGG?ATCGGCGTGG?GCAAGTGTTG?CTACAGCTAT?ACAAGGTTTT 360

GCTCTAACGC?CATCAAGTGG?CTGTAATTTT?GGTTGGAACG?CATTGATAAA?TAAAAACATA 420

GATGTATCCA?TGGATAGCGT?GCTAGACAAT?TTGAGCAACA?AAATTCAGAA?TTTTACCAAA 480

GGCGGTGTTG?AGGACAATGT?GAAAGGCAAT?ATTCTTTTAC?AAATAATTGG?CTCAATAACC 540

GCTCAAGCTT?CTACGAATAT?TACAGCTGAT?GGTTTAATTT?GGCTGATTGG?TAAAGAATTC 600

ACTGCAAATA?AACTGCAAAA?CAACACTACA?GCCATGCTTG?CTTTTGCCGC?ATTAGAATCT 660

GTTGTCAAAG?GAGCGGACGC?TGCTGTTCTT?CCTGCATATG?GTGTAGTCAA?TCTGCCTGAT 720

ATTATCATAG?GGCAAGGGTC?ATATCTTGAT?TTTGTTTCTT?ACCTAATTTA?TATCGTTTTT 780

GGGATTTTTG?TTTTTATTTC?TTTTATGAAA?TTGAGGGATA?TTTCAAGTAA?CATTCAGATT 840

AACATAGGTT?TTGAATACAT?GCGATTTGTT?GGGGGGACAT?TATTCAAAAT?GGCGATGGTC 900

TCTTTTATCG?CCTATGCAGG?TTTTGGTTAT?CTTTATAAAA?TCTCTTATTC?TATTTATTTT 960

GGTTTAGCAG?GCGCTTTTGG?GCTGAATCAA?GTTCTTTTTT?GGGCTTTAGA?TTTAGTGCTG 1020

AATTACACTG?TTAATTCAAT?TTTACCTGCG?GTAAGAGCTG?TTTTTTCTAA?TGTTGGCAAC 1080

AACGCTCCTA?GTTTGTTACA?AGGCTTGCAA?GTGGCAGGTA?TTTCTTTATT?CGCCATTTTT 1140

ATGCAAGTAA?CTATCATTAT?GAGAATAAGC?ACTGTTGTTG?TGAAACCTTT?GATAGCTGGG 1200

GCTTTTAGCG?GTATTGTGTT?CCCTATTGCA?GTAAGTTTGA?TCGTGCTAGA?TTGGTTCAAA 1260

GATTCTATGA?AAAACATATT?GATATGGTTT?ATTAATAATT?TGTTTATCTT?GGTTCTAGCT 1320

ATTCCTATTT?TGCTCTTTGG?TGTTTTGGCA?TTATTGGCAT?TCAATTTGAC?CATAACGCCC 1380

TCTGTTGCTA?TACAAAACAT?CAATCAAGGG?GGACTAGGTA?TCGATTCAAC?TATTGCGAGT 1440

TTGATCACCC?TATTTATTTT?AAAAGGTTTC?ATAGAGACGA?TTATTGAGAG?CGTCAATGCG 1500

ATCGTTAATA?CCATTTTTAG?CTCTGTTTCT?ATGGATGGTA?GCAGAATGGA?TAGAGAAAGA 1560

GATGCCTTAA?TGGTTGGAAG?AGTTGGTGGA?TCTATGTTTA?AAGGATAA 1608

<210>10

<211>759

<212>DNA

<213>HELICOBACTER?PYLORI

<400>10

ATGTTAGGGA?AAAAAAACGA?AGAAGTCTTG?ATTGATGAAA?ATTTGGTTGG?GGGTGTGATA 60

GCCCTTGATA?GATTGGCAAA?ACTCAATAAG?GCCAATAGGA?CTTTCAAAAG?GGCTTTTTAT 120

CTCTCTATGG?CACTCAATGT?CGCCGCTGTA?ACGAGTATTG?TGATGATGAT?GCCTTTGAAG 180

AAAACGGATA?TATTTGTTTA?TGGCATTGAT?CGATACACAG?GAGAATTTAA?AATTGTCAAA 240

CGCTCCGATG?CTAGGCAAAT?CGTCAATTCT?GAAGCCGTTG?TGGATAGTGC?AACTTCAAAA 300

TTTGTATCAT?TGCTGTTTGG?TTATAGCAAA?AATTCTTTGA?GGGATCGCAA?GGATCAACTA 360

ATGCAGTATT?GCGATGTGAG?TTTCCAAACC?CAAGCAATGA?GAATGTTCAA?TGAAAATATC 420

AGACAATTCG?TAGATAAAGT?CCGAGCAGAA?GCTATCATTA?GCTCTAACAT?ACAAAGAGAA 480

AAAGTCAAAA?ATAGTCCCTT?AACGAGATTA?ACATTTTTCA?TTACCATCAA?AATCACACCT 540

GATACAATGG?AAAATTATGA?ATATATCACT?AAAAAACAAG?TAACTATTTA?TTATGATTTT 600

GCTAGAGGTA?ACTCTTCTCA?AGAAAATCTT?ATCATCAATC?CTTTTGGCTT?CAAAGTGTTT 660

GACATTCAAA?TCACAGATTT?ACAAAACGAA?CAGACGGTAA?GCGAAATTTT?GAGAAAGATC 720

AGAGAAGTGG?AATCAAAAAA?TAAGGCATTA?AATAAATAA 759

<210>11

<211>657

<212>DNA

<213>HELICOBACTER?PYLORI

<400>11

ATGAACGATA?CAACAGAGCA?TCATGGACCT?AATCCGCTAA?ACGCTCCACC?ACCTAGCAAC 60

TCACAGAGCA?ATGATCTTTT?AAATTTGCTA?GACTCATTAT?ATCCTAAAGG?GAGTTTAGGG 120

GAGCAAAGAT?TTCACGAAGC?TTTAAAGAAT?CAAGAAGAGT?TGAAAAATAT?CCTAATAGAA 180

ATAGAAAAGC?TACCGCAAGA?AAAAAGGTAT?GAACTTCTGA?TGCAGATAGG?ACAAGCCAAG 240

CAAAGAATAA?TGGAAGCATA?TGCTCATTCA?TTCTTAGGAT?ATATAGGGGG?ACTAGAGCAT 300

CTGTTAGGAT?TGTGTATGGG?TGGGATATTT?GTTTTGTTTG?CAATCTATTT?TGTATTTTTA 360

AGAACTAGCA?AAAACATGGA?GCTAGTGGAA?AGTCTAAAAA?CAAAACTAAA?ACTTCAGTAT 420

TTTTACTATG?CCTTTGGTGT?GGGTGCGGTT?TTGTTTTTTG?GATTAGAAAC?AATTAGATCT 480

ATTTATGAAC?TATATATCTT?AGGAATTGGT?AGCACTAACG?ACAAGGTGCT?CTTTGTTTTG 540

AAAAACATTT?GCTTCATAGG?TATGGGCTAT?TTGATTTATA?AAGTTATTAA?GGTTATTGGT 600

ATAAAAAATT?TTATCAATGG?TCTTTTCACT?TCAAAGAAAC?AAGGCGGTGC?AGAATGA 657

<210>12

<211>839

<212>DNA

<213>HELICOBACTER?PYLORI

<400>12

ATGAAACTGA?GAGCAAGTGT?TTTAATCGGT?GCGACAATTC?TGTGCTTAAT?TTTAAGCGCA 60

TGCAGTAATT?ATGCGAAAAA?AGTGGTGAAA?CAAAAGAACC?ATGTTTATAC?GCCTGTGTAT 120

AATGAACTGA?TAGAGAAGTA?TAGTGAGATA?CCCTTAAATG?ACAAACTCAA?AGACACACCA 180

TTCATGGTGC?AAGTGAAGTT?GCCAAATTAC?AAGGACTATT?TGTTGGATAA?TAAACAAGTT 240

GTACTAACTT?TCAAACTTGT?TCACCATTCT?AAAAAGATTA?CGCTCATAGG?CGATGCCAAT 300

AAGATACTTC?AATACAAGAA?TTACTTCCAA?GCTAATGGAG?CGAGATCTGA?CATTGATTTT 360

TACTTGCAAC?CCACTTTGAA?TCAAAAGGGT?GTGGTGATGA?TAGCGAGTAA?CTACAATGAT 420

AATCCTAACA?GCAAAGAAAA?ACCACAGACC?TTTGATGTGT?TGCAAGGAAG?TCAGCCAATG 480

CTAGGAGCTA?ACACAAAAAA?CTTGCATGGC?TATGATGTGA?GTGGAGCAAA?CAACAAGCAA 540

GTGATCAATG?AAGTGGCAAG?AGAAAAAGCT?CAGCTAGAAA?AAATCAATCA?GTATTACAAA 600

ACTCTTTTAC?AAGACAAGGA?ACAAGAATAT?ACCACTAGGA?AAAATAACCA?ACGAGAAATT 660

TTAGAAACAT?TGAGTAATCG?TGCAGGTTAT?CAAATGAGGC?AGAATGTGAT?TAGTTCTGAG 720

ATTTTTAAGA?ATGGCAACTT?GAACATGCAA?GCCAAAGAGG?AAGAAGTTAG?GGAGAAGCTA 780

CAAGAAGAAA?GAGAGAATGA?ATACTTGCGA?AATCAAATCA?GAAGTTTGCT?CAGTGGTAAG 840

TGA 843

<210>13

<211>591

<212>DNA

<213>HELICOBACTER?PYLORI

<400>13

ATGAGTAATA?ACATGCGAAA?ACTCTTCTCA?ATGATTGCTG?ACTCAAAAGA?TAAGAAAGAA 60

AAACTTATTG?AGAGTTTGCA?AGAGAACGAA?CTTTTAAGCA?CTGATGAAAA?AAAGAAAATC 120

ATAGATCAAA?TAAAAACCAT?GCATGATTTT?TTCAAACAGA?TGCATACAAA?CAAGGGAGCG 180

TTAGATAAGG?TTCTAAGAAA?TTACATGAAA?GATTATCGCG?CTGTTATCAA?AAGCATTGGT 240

GTTGATAAGT?TTAAAAAGGT?TTATCGATTG?CTTGAGAGTG?AGACTATGGA?GCTGTTGCAT 300

GCCATTGCAG?AGAATCCTAA?TTTCTTATTC?TCCAAATTTG?ATCGATCAAT?TCTTGGAATA 360

TTTCTGCCTT?TCTTCAGTAA?GCCTATCATG?TTCAAGATGA?GTATTAGAGA?AATGGACTCG 420

CAAATAGAAT?TGTATGGCAC?TAAGCTCCCA?CTATTGAAAT?TGTTTGTGAT?GACAGATGAA 480

GAAATGAATT?TCTACGCTAA?TCTAAAAACC?ATTGAACAAT?ATAACGACTA?TGTTAGGGAT 540

TTGCTGATGA?AATTTGATCT?TGAAAAATAC?ATGAAAGAAA?AAGGAGTGTA?A 591

<210>14

<211>381

<212>DNA

<213>HELICOBACTER?PYLORI

<400>14

ATGCTTCCTA?CTAAAACACG?CATTAGAGAT?CCGAACAAGC?AAGAACTTAC?ACAACCAAAA 60

ATAAAAGGAC?TGATCATGGG?AAAAATTTTA?GCTTCTTTGT?TGGGTGGCGG?AACAAATCTT 120

TTTACAGGTT?TATCCAGTGA?TTTGTTTTCT?ATGATATTAA?ATTTTTTGTT?CTTCCTGATG 180

TTAATGATGG?GACTTAATGA?AATATTAGGG?AAAAAATTCA?ACTTGCCTAT?GGACAATATC 240

AAGAATTTTA?TGGCAGAAGT?GTTGAAGAAT?GGATTCGATA?GTATCAAAAA?CATGGGATCT 300

GCTTTGGTTG?GTAATGGTTT?TGGTAGCAAC?AAATCAGACA?AAACCACTAA?TAAAATGAGT 360

GTCTCTCAAG?TAAGACTCTA?G 381

<210>15

<211>345

<212>DNA

<213>HELICOBACTER?PYLORI

<400>15

ATGAAACGAC?CGATTAGCAA?GTTAAAACAA?AACTTTTTAC?AATTCAAACA?TTCTTTCAAC 60

AAACATTTAG?ATAAATACAG?CCTTTATTAT?AGGCTGTTCA?ATATCAGTTC?TATCGTTATA 120

GGTTTTTTAG?TAGCCCTTTT?TTCTTATGGG?GCAGGGGTGA?TTTTAGTTTA?TCCAATATTA 180

TTCCTATTTG?CTCTTATAAT?AAAACCTAGC?TTTTTTTATT?ACACTACTTA?TCTTTTGCTA 240

CTCGTTTCTC?TCAGCATAAT?AAGCAAATAC?TATCTCTTAA?GCCACGCAAA?TTTCACAATG 300

AAGCTAATCA?TACTTATGAC?TCAATGGCAA?AATTGGTTCT?TATGA 345

<210>16

<211>1131

<212>DNA

<213>HELICOBACTER?PYLORI

<400>16

ATGCTTGCAA?AAATCGTTTT?TAGCTCATTG?GTTGCGTTTG?GAGTTTTGTC?GGCTAATGTG 60

GAGCAGTTTG?GTTCATTTTT?CAACGAGATA?AAAAAAGAAC?AAGAAGAAGT?GGCTGCAAAA 120

GAAGACGCTC?TTAAGGCTCG?CAAGAAGCTC?TTAAACAATA?CGCATGATTT?CTTAGAAGAC 180

TTGATTTTTA?GAAAACAAAA?AATCAAAGAG?CTTATGGATC?ATAGAGCTAA?AGTTCTTTCA 240

GACTTAGAAA?ACAAATACAA?AAAAGAAAAA?GAGGCTCTAG?AGAAAGAGAC?AAGAGGTAAA 300

ATCCTTACTG?CTAAGTCAAA?GGCTTATGGG?GATTTGGAGC?AAGCCTTAAA?AGATAACCCT 360

CTCTATAGGA?AACTTCTTCC?TAACCCTTAT?GCCTATGTTT?TAAACCAAGA?AACATTCACC 420

AAAGAAGATA?GGGAGCGTTT?GAGTTATTAC?TACCCCCAGG?TGAAAACGAG?CAGTATTTTT 480

AAAAAAACCA?CCGCTACCAC?TAAAGATAAG?GCTCAGGCTT?TGCTTCAAAT?GGGTGTGTTT 540

TCTTTAGATG?AAGAACAAAA?CAAAAAAGCG?AGCCGATTAG?CTTTATCTTA?CAAGCAAGCG 600

ATTGAAGAAT?ATTCCAATAA?CGTTTCTAAT?TTATTGAGCA?GAAAAGAATT?GGATAATATA 660

GATTATTACT?TACAGCTTGA?AAGAAACAAG?TTTGACTCCA?AAGCAAAAGA?TATTGCTCAA 720

AAGGCTACTA?ACACGCTTAT?TTTTAATTCG?GAACGCTTGG?CGTTTAGCAT?GGCGATTGAT 780

AAGATCAATG?AGAAATACTT?AAGGGGCTAT?GAGGCTTTTT?CTAACTTGTT?GAAAAATGTC 840

AAAGATGATG?TGGAATTGAA?TACTCTGACT?AAAAATTTTA?CCAATCAAAA?ATTGAGTTTC 900

GCACAAAAAC?AAAAATTGTG?TTTGTTGGTT?TTAGACAGCT?TCAATTTTGA?TACCCAATCC 960

AAAAAATCTA?TATTAAAAAA?GACTAATGAA?TACAATATTT?TCGTAGATAG?CGATCCTATG 1020

ATGAGCGACA?AAACCACTAT?GCAAAAAGAA?CACTACAAGA?TATTTAATTT?CTTCAAAACA 1080

GTGGTTTCTG?CATACCGAAA?CAATGTTGCC?AAGAATAATC?CCTTTGAATA?G 1131

<210>17

<211>921

<212>DNA

<213>HELICOBACTER?PYLORI

<400>17

TTGAAAAGTA?TCTTCAAAAA?ACTAGGTTCT?GTCGCTCTTT?ATTCTTTAGT?TATTTATGGG 60

GGCTTAAACG?CTATCAATAC?AGCATTATTG?CCGAGTGAAT?ACAAAGAATT?AGTGGCTTTG 120

GGCTTTAAAA?AAATCAAAAC?ACTCCATCAA?AGACATGACG?ACGAAGAAGT?TACAAAAGAG 180

GAAAAAGAAT?TCGCCACTAA?CGCTTTGAGA?GAAAAATTAC?GAAATGATAG?GGCAAGAGCA 240

GAGCAAATTC?AAAAGAATAT?TGAAGCGTTT?GAAAAAAAGA?ACAACTCTTC?TATTCAAAAA 300

AAAGCGGCTA?AGCACAAAGG?ATTACAAGAA?TTAAACGAAA?TTAACGCTAC?CCCTTTGAAT 360

GACAACCCTA?ATAGCAATTC?TTCCACTGAA?ACCAAATCTA?ATAAAGATGA?TAACTTTGAT 420

GAGATGATCA?ATAAGGTGAA?TGGAGCTTTT?GTGAAACCTG?CTACTCCGCT?TGTGCCTGAT 480

GAGTGGAGAA?CGCCTGAAAT?TGAAATCATT?ATCAATGAGT?GTATTATTTC?AAGCAACGAT 540

TATGATGGGT?TAAGAAAGTG?TTTGATCAAA?GGCATCAAGG?ATCAAAAAAT?TCTTGCCCCC 600

TTATTAGAAA?AAATTCAAGA?AATAGAGACA?GAAAATAACA?AATTTTCTAG?ACAACACTTG 660

AGTGGTTTAA?AACTCGCTCT?TAATAACAGC?AACAATAGAA?CCTTTCTTAT?AGCTTCGTGC 720

GCTATTTGTG?AGAAGAGAAA?AAAAGAAATG?GAGCAAGAAA?ATAACTACCA?AGATACTACA 780

AATGCAAGTG?AGTTTGGAGC?TACTGATACA?AAAGAAAATG?AAGCAAAAGA?TGCAGCATTC 840

TCAAACAATC?GCTCTAAATC?TGAACTGCCC?AATAGCGTCA?TTAATCAAAT?AGAACAAAGC 900

ATCGCTCATG?GGAAAAAATA?G 921

<210>18

<211>714

<212>DNA

<213>HELICOBACTER?PYLORI

<400>18

ATGAAAACAC?TCGTGAAAAA?TACCATATCT?TCTTTTTTGC?TCTTGTCTGT?TTTGATGGCA 60

GAAGATATAA?CAAGCGGTTT?AAAGCAACTG?GATAGCACCT?ACCAAGAGAC?CAACCAACAA 120

GTGCTCAAAA?ACTTAGATGA?GATTTTTTCA?ACCACTAGCC?CTAGTGCTAA?TAATGAAATG 180

GGTGAAGAAG?ATGCTCTAAA?CATCAAAAAA?GCGGCCATTG?CTTTGAGAGG?AGATTTAGCG 240

TTATTGAAAG?CCAATTTTGA?AGCGAATGAG?TTATTTTTCA?TCTCAGAAGA?TGTGATTTTC 300

AAAACTTATA?TGTCTAGCCC?TGAACTTTTA?TTAACCTATA?TGAAAATCAA?TCCCTTAGAC 360

CAAAATACTG?CTGAGCAACA?ATGCGGAATA?TCCGATAAAG?TTTTAGTTCT?TTATTGTGAA 420

GGGAAGCTGA?AAATCGAGCA?AGAAAAACAA?AATATAAGAG?AGCGTTTAGA?AACTTCTCTA 480

AAGGCATATC?AGAGCAACAT?TGGAGGTACA?GCTTCCTTAA?TCACTGCTTC?ACAGACGCTT 540

GTAGAAAGCC?TAAAAAATAA?AAATTTCATC?AAAGGAATCA?GAAAGCTTAT?GTTAGCTCAC 600

AACAAGGTCT?TTTTAAATTA?TTTAGAGGAG?TTGGACGCAT?TAGAAAGATC?CCTAGAACAA 660

AGTAAGCGAC?AATACCTACA?AGAAAGGCAA?TCAAGTAAGA?TCATTGTTAA?ATGA 714

<210>19

<211>1146

<212>DNA

<213>HELICOBACTER?PYLORI

<400>19

GTGAAATGTT?TTTTAAGCAT?ATTTTCTTTC?TTGACTTTTT?GTGGTTTGTC?TCTGAATGGC 60

ACAGAAGTAG?TAATAACGCT?TGAACCCGCC?TTAAAAGCCA?TTCAGGCGGA?CGCACAAGCC 120

AAACAAAAAA?CCGCTCAAGC?TGAATTAAAA?GCCATAGAAG?CTCAGTCTAG?TGCCAAAGAA 180

AAAGCCATTC?AAGCGCAAAT?AGAGGGAGAA?TTGAGGACTC?AGCTTGCAAC?CATGAGTGCT 240

ATGTTAAAAG?GGGCTAATGG?CGTTATTAAT?GGTGTCAATG?GCATGACAGG?GGGGTTTTTT 300

GCAGGTTCAG?ACATCTTGCT?TGGCGTCATG?GAAGGGTATT?CAAGCGCGCT?TAGTGCATTG 360

GGGGGGAATG?TTAAAATGAT?CGTGGAAAAA?CAAAAAATTA?ACACCCAAAC?AGAAATCCAA 420

AACATGCAAA?TCGCGCTCCA?AAAAAATAAC?GAAATAATCA?AGCTCAAAAT?GAACCAGCAA 480

AACGCTCTCT?TAGAAGCGTT?AAAAAATAGC?TTTGAACCGA?GCGTTACTCT?AAAAACACAA 540

ATGGAAATGC?TTTCTCAAGC?TCTAGGAAGT?TCTTCTGACA?ACGCTCAATA?CATCGCTTAC 600

AATACGATTG?GTATCAAGGC?GTTTGAAGAA?ACCTTAAAAG?GTTTTGAAAC?ATGGTTGAAA 660

GTGGCTATGC?AAAAAGCGAC?CCTTATTGAT?TATAATTCCC?TAACGGGTCA?GGCTTTGTTT 720

CAAAGTGCCA?TCTATGCGCC?TGCTCTTAGT?TTTTTTTCAA?GCATGGGTGC?ACCATTTGGA 780

ATCATTGAAA?CATTCACTCT?AGCGCCCACA?AAATGCCCCT?ATCTTGATGG?GCTAAAAATT 840

TCAGCATGCC?TTATGGAACA?GGTTATTCAG?AATTACAGAA?TGATTGTAGC?CCTTATTCAA 900

AATAAACTGA?GTGATGCAGA?TTTTCAAAAT?ATCGCTTATT?TGAATGGGAT?CAATGGAGAA 960

ATCAAAACCT?TAAAAGGATC?AGTAGATTTG?AACGCGCTCA?TAGAAGTTGC?TATCTTAAAC 1020

GCAGAAAATC?ATTTAAACTA?TATAGAGAAT?CTTGAAAAAA?AAGCCGACCT?TTGGGAAGAA 1080

CAACTGAAAT?TAGAAAGAGA?AACGACAGCA?AGAAACATTG?CTAGCTCTAA?AGTTATTGTC 1140

AAATGA 1146

<210>20

<211>1113

<212>DNA

<213>HELICOBACTER?PYLORI

<400>20

ATGGCAGGTA?CACAAGCTAT?ATATGAATCA?TCTTCTGCAG?GATTCTTATC?GGAAATTTCC 60

TCAATCATCT?CAAGCACAAG?TGGTGTTGCA?GGGCCATTTG?CAGGAATAGT?AGCGGGTGCT 120

ATGTCAGCAG?CGATTATTCC?TATTGTTGTG?GGATTTACTA?ATCCGCAAAT?GACCGCTATC 180

ATGACCCAAT?ACAATCAGAG?CATCGCTGAA?GCCGTAAGCA?TGCCTATGAA?AGCTGCTAAC 240

CAACAATACA?ACCAATTGTA?TCAAGGTTTT?AACGATCAAA?GCATGGCTGT?GGGGAACAAT 300

ATCTTAAATA?TCAGCAAATT?AACAGGGGAA?TTTAACGTGC?AAGGCAACAC?GCAAGGCGCG 360

CAAATTAGTG?CCGTTAATAG?TCAGATTGCA?AGCATTTTAG?CGAGTAACAC?CACCCCTAAA 420

AATCCTAGCG?CTATTGAAGC?TTATGCGACA?AATCAAATCG?CTGTTCCTAG?TGTGCCAACA 480

ACGGTTGAAA?TGATGAGCGG?TATCTTAGGC?AATATTACAA?GCGCGGCACC?AAAATACGCC 540

CTAGCTCTAC?AAGAGCAATT?GCGTTCTCAA?GCAAGCAACA?GCTCAATGAA?TGATACAGCC 600

GATTCCCTTG?ATAGCTGTAC?CGCTTTAGGT?GCACTTGTTG?GCTCATCAAA?AGTGTTTTTT 660

AGTTGCATGC?AAATTTCTAT?GACGCCCATG?AGTGTTTCTA?TGCCCACTGT?TTATGCCAAA 720

TACCAAGCGT?TASCNACTAA?TGCCCTAACT?TCAGGCACTA?ATCCTATGAC?CACTCCTGCA 780

TGCCCTATTG?GGGACAAAGT?TCTTGCCGTT?TATTGCTATG?CTGAAAAAGT?AGCAGAAATT 840

TTGAGGGAAT?ACTATATAGA?ATTTGTGAAA?AACAATACCA?ATTTGTTGCA?AAACGCTTCT 900

CAAATGATAC?TTAATCAATC?AGGATTAGCT?ACTAGCACCT?ATGACACTCA?AGCGATTTCT 960

AACATAAGCT?CGCTATATAA?TTACAATATA?GTAGCGAATA?AATCTTTTTT?GAAATCGCAT 1020

TTGACTTACC?TTGATTACAT?CAAAAACAAG?CTTAAGGGGC?AAAAAGATAG?CTACTTAACA 1080

GAAAGGGTGC?AAACTAAAAT?AATCGTGAAG?TGA 1113

<210>21

<211>429

<212>DNA

<213>HELICOBACTER?PYLORI

<400>21

ATGAAAACGA?ATTTTTATAA?AATTAAATTA?CTATTTGCTT?GGTGTCTTAT?CATTGGCATG 60

TTTAACGCTC?CGCTTAATGC?TGACCAAAAC?ACGGATATAA?AAGATATTAG?TCCTGAAGAT 120

ATGGCACTAA?ATAGCGTGGG?GCTTGTTTCT?AGAGATCAAC?TAAAAATAGA?GATCCCTAAA 180

GAAACCCTAG?AACAAAAAGT?GGCCGTACTC?AATGACTATA?ATGATAAGAA?TGTTAATATC 240

AAGTTTGACA?ACATAAGTTT?AGGGAGTTTT?CAACCTAATG?ATAATCTAGG?TATCAATGCG 300

ATGTGGGGCA?TTCAAAATCT?TCTCATGAGC?CAAATGATGG?GCGATTACGG?TCCAAACAAT 360

CCTTTCATGT?ATGGTTATGC?ACCAACATAC?TCAGATTCAT?CATTTTTACC?ACCGATCTTA 420

GGGTATTAA 429

<21O>22

<211>807

<212>DNA

<213>HELICOBACTER?PYLOR

<400>22

ATGAAACAAA?GTTTGCGCGA?ACAAAAATTA?TTGAAAATTT?TAGAAAATGA?TGTCTTGACG 60

ATTTTGGATA?GTTTTTCTAA?TTATCTTTTT?GAACTGAGAG?AAGAGTTGGA?CTTCATAGAA 120

GAAGAAATGG?AAGGTGAAAT?CACCGAACAA?AACCTTACCG?CTCTTTATGA?TTTTTCTAAT 180

TTCTTAGAAG?ACCATGTCAA?TGTATTTTAT?GAGAATGTTT?TGAATATAGA?TGATGTCAAA 240

ACAGAACACC?TTTATTCAGG?TCTCATAGAT?AGTCTTAACG?CTAATCTTCA?CTTTGTCAAG 300

TCATTTCTCA?GTAATCAGGA?TTTAGACTTC?CGCTTTTTTA?AGGAAATAAA?CGATGGGCAA 360

GATCCCCAAA?AAACATTATC?AAGATTAATT?CCTCTTCAAA?GTGGGAAAAA?TGATGCAAGC 420

TCGTTTAAAG?CCAATAATTC?TTTTGTTTCA?TTAGTTTATG?TTTATGTTTA?CTTCATGCTA 480

GAAACTATCA?TGCAGTCGTA?TAGGATTCTC?AGATTGCTAG?AAAAACCTAT?CAATAACAAC 540

ATAAGCGAGG?ACATGCAGAA?CGATATAGAG?AATTTTTTTG?TTCAAGCGAA?TTTTTTAGAA 600

TACTATGTTC?AGAACAAAAT?ATACCCAACC?AATCATGCCT?ATGACTTCAC?GCATTTGATC 660

ATGGACTCCA?TTATTCCTAA?TTGGATTCAA?ACTGATATGA?GCGTTGAAGC?TAAAAAGAAA 720

GAGCTTTTTG?AAAAATATTT?TCAAAACATT?GATGAAGTAA?CAAACAAAAT?GCTCGATCAA 780

AAAAATCAAA?ACAANAGTAA?CGATTGA 807

<210>23

<211>2952

<212>DNA

<213>HELICOBACTER?PYLORI

<400>23

GTGTTTGTGG?CAAGCAAACA?AGCTGACGAA?CAAAAAAAGC?TAGTCATAGA?GCAAGAGGTT 60

CAAAAGCGCC?AATTTAAAAA?AATAGAAGAA?CTTAAAGCAG?ACATGCAAAA?GGGTGTCAAT 120

CCCTTTTTTA?AAGTCTTGTT?TGATGGGGGG?AATAGGTTGT?TTGGTTTCCC?TGAAACTTTC 180

ATTTATTCCT?CTATATTTAT?ATTGTTTGTA?ACAATTGTAC?TATCTGTTAT?TCTTTTTCAA 240

GCCTATGAAC?CTGTTTTGAT?TGTAGCGATT?GTTATTGTGC?TTGTAGCTCT?TGGATTCAAG 300

AAAGATTATA?GGCTTTATCA?AAGAATGGAG?CGAGCGATGA?AATTTAAAAA?ACCTTTTTTG 360

TTTAAGGGCG?TGAAAAACAA?AGCGTTCATG?AGCATTTTTT?CCATGAAGCC?TAGTAAAGAA 420

ATGGCTAATG?ACATCCACTT?AAATCCAAAC?AGAGAAGACA?GGCTTGTGAG?CGCTGCAAAC 480

TCCTATCTAG?CGAATAACTA?TGAATGTTTT?TTAGATGATG?GGGTGATCCT?TACTAACAAC 540

TATTCTCTTT?TAGGCACAAT?CAAATTGGGG?GGCATTGATT?TTTTAACCAC?TTCCAAAAAA 600

GATCTCATAG?AGTTACACGC?TTCTATTTAT?AGCGTTTTTA?GGAATTTTGT?TACCCCTGAA 660

TTCAAATTCT?ATTTTCACAC?TGTTAAAAAG?AAAATCGTTA?TTGATGAAAC?CAATAGGGAC 720

TATAGTCTTA?TTTTTTCTAA?TGATTTCATG?CGAGCCTATA?ATGAGAAGCA?AAAGAGAGAA 780

AGTTTTTATG?ATATTAGTTT?TTATCTCACC?ATAGAGCAAG?ATTTATTAGA?CACTCTCAAT 840

GAACCCGTTA?TGAATAAAAA?GCATTTTGCA?GACAATAATT?TTGAAGAGTT?TCAAAGGATT 900

ATTAGAGCCA?AGCTTGAAAA?CTTCAAGGAT?AGGATAGAGC?TCATAGAAGA?GCTATTGAGT 960

AAATACCACC?CCATTAGATT?AAAAGAATAC?ACTAAAGATG?GCGTTATTTA?CTCCAAACAA 1020

TGCGAGTTTT?ATAATTTCCT?TGTGGGAATG?AATGAAGCCC?CTTTTATTTG?CAACAGAAAA 1080

GACTTGTATC?TCAAGGAAAA?AATGCATGGT?GGGGTGAAAG?AAGTTTATTT?TGCCAATAAG 1140

CATGGAAAAA?TCTTAAATGA?CGATTTGAGT?GAAAAATATT?TTAGCGCTAT?TGAGATTAGT 1200

GAATACGCCC?CTAAATCACA?AAGCGATTTG?TTTGATAAAA?TCAACGCCCT?AGACAGCGAA 1260

TTTATTTTCA?TGCATGCTTA?TTCGCCTAAA?AACTCACAGG?TTTTAAAGGA?CAAACTAGCT 1320

TTCACCTCTA?GAAGAATTAT?TATTAGTGGA?GGCTCTAAAG?AGCAGGGCAT?GACTTTAGGT 1380

TGCTTGAGCG?AATTAGTGGG?TAATGGTGAT?ATTACGCTAG?GCAGTTATGG?TAATTCTTTA 1440

GTGTTGTTTG?CTGATAGCTT?TGAAAAAATG?AAACAAAGCG?TTAAGGAATG?CGTCTCTAGT 1500

CTTAACGCTA?AAGGTTTTTT?AGCCAACGCA?GCGACTTTCT?CTATGGAAAA?TTACTTTTTC 1560

GCCAAACATT?GCTCTTTTAT?CACGCTTCCT?TTTATTTTTG?ATGTAACTTC?TAATAATTTT 1620

GCTGATTTCA?TCGCTATGAG?GGCTATGAGT?TTTGATGGCA?ATCAGGAGAA?TAACGCTTGG 1680

GGCAATAGTG?TGATGACGCT?AAAAAGCGAG?ATCAATTCGC?CTTTTTATCT?GAACTTCCAC 1740

ATGCCTACTG?ATTTTGGTTC?AGCTTCAGCA?GGACACACTT?TGATACTTGG?CTCAACCGGT 1800

TCAGGTAAGA?CAGTGTTTAT?GTCAATGACC?TTGAACGCTA?TGGGGCAATT?TGTTCACAAT 1860

TTTCCTGCTA?ATGTCAGCAA?AGACAAGCAA?AAGCTCACTA?TGGTTTATAT?GGATAAAGAT 1920

TATGGCGCTT?ATGGGAATAT?TGTCGCAATG?GGTGGGGAGT?ATGTCAAGAT?TGAGCTAGGG 1980

ACAGATACAG?GATTAAATCC?TTTTGCTTGG?GCGGCTTGTG?TGCAAAAAAC?AAATGCAACA 2040

ATGGAGCAAA?AACAAACAGC?TATTTCTGTT?GTCAAAGAGC?TTGTGAAAAA?CTTAGCAACC 2100

AAAAGCGATG?AAAAAGATGA?GAATGGCAAC?AGCATCTCTT?TTAGCCTAGC?AGATTCTAAT 2160

ACGCTTGCAG?CGGCAGTAAC?CAACCTTATC?ACAGGAGATA?TGAACCTAGA?TTATCCCATC 2220

ACTCAACTTA?TTAATGCTTT?CGGGAAAGAC?CACAATGATC?CTAATGGGCT?TGTCGCGCGA 2280

TTAGCACCTT?TTTGCAAATC?AACCAATGGT?GAATTTCAAT?GGCTTTTTGA?TAATAAAGCA 2340

ACGGATCGCT?TAGATTTTTC?AAAAACGATT?ATTGGCGTTG?ATGGGTCAAG?TTTCTTAGAC 2400

AATAATGATG?TTTCGCCCTT?TATTTGTTTT?TACCTTTTCG?CTCGTATCCA?AGAGGCAATG 2460

GATGGGCGTA?GATTTGTCTT?AGATATTGAT?GAAGCTTGGA?AATATTTAGG?CGATCCAAAG 2520

GTCGCTTATT?TTGTAAGAGA?CATGCTAAAA?ACTGCAAGGA?AAAGAAACGC?TATTGTCAGA 2580

CTTGCGACTC?AAAGCATCAC?TGATCTTTTG?GCTTGCCCTA?TTGCTGATAC?GATTAGAGAA 2640

CAATGCCCTA?CAAAGATTTT?TTTGAGAAAC?GATGGGGGCA?ATCTTTCTGA?TTACCAAAGA 2700

TTGGCTAATG?TTACAGAAAA?AGAATTTGAA?ATCATCACTA?AGGGACTAGA?TAGGAAAATT 2760

CTCTACAAAC?AGGATGGAAG?CCCTAGCGTT?ATCGCTAGTT?TTAATTTGAG?GGGCATTCCT 2820

AAAGAATATT?TGAAAATTTT?ATCCACAGAT?ACTGTATTTG?TCAAAGAAAT?TGACAAGATT 2880

ATCCAAAACC?ATAGTATCAT?AGATAAATAT?CAGGCCTTGA?GGCAAATGTA?TCAACAAATA 2940

AAGGAGTATT?AA 2952

<210>24

<211>624

<212>DNA

<213>HELICOBACTER?PYLORI

<400>24

TTGATCAATA?ATAATAGTAA?TAAAAAACTG?AGAGGCTTTT?TTGTGAAAGT?TCTCTTAAGT 60

CTCGTTGTTT?TCAGTTCGTA?TGGGTTAGCA?AATGACGATA?AAGAAGCCAA?AAAAGAAGTG 120

CTAGAAAAAG?AAAAAAACAC?TCCCAATGGG?CTTGTTTATA?CGAATTTAGA?TTTTGATAGT 180

TTCAAGGCGA?CTATCAAAAA?TTTGAAAGAC?AAGAAAGTAA?CTTTCAAAGA?AGTCAATCCC 240

GATATTATCA?AAGATGAAGT?TTTTGACTTC?GTGATTGTCA?ATAGAGTCCT?TAAAAAAATA 300

AAGGATTTGA?AGCATTACGA?TCCAGTTATT?GAAAAAATCT?TTGATGAAAA?GGGTAAAGAA 360

ATGGGATTGA?ATGTGGAATT?GCAGATCAAT?CCTGAAGTGA?AAGACTTTTT?TACTTTTAAA 420

AGCATCAGCA?CGACCAACAA?ACAACGCTGC?TTTCTATCGT?TGCGCGGGGA?AACAAGAGAA 480

ATTTTATGCG?ATGATAAGCT?GTATAATGTT?TTATTGGCCG?TATTCAATTC?TTATGACCCT 540

AATGATCTTT?TGAAACATAT?TAGCACCGTA?GAGTCTCTCA?AAAAAATCTT?TTATACGATT 600

ACATGTGAAG?CGGTATATCT?ATAA 624

<210>25

<211>348

<212>DNA

<213>HELICOBACTER?PYLORI

<400>25

ATGAAATTTT?TTACAAGAAT?CACTGACAGC?TACAAGAAAG?TTGTAGTAAC?TTTAGGGCTA 60

GTGGTAACAA?CCAATCCTTT?AATGGCGGTC?ACCAGTCCTG?CAGAAGGCGT?TACTGAGACT 120

AAAACTTTGG?TTATTCAGAT?CATTTCTGTT?CTAGCGATCG?TAGGGGGTTG?CGCTTTAGGG 180

GTCAAAGGCA?TAGCGGATAT?TTGGAAAATC?TCTGATGATA?TCAAAAGAGG?TCAGGCGACT 240

GTTTTTGCTT?ACGCGCAACC?CATAGCTATG?TTAGCGGTGG?CAGGCGGTAT?TATCTATTTG 300

AGCACTAAGT?TTGGCTTCAA?TATTGGCGAG?AGCGGAGGAG?CTAGCTAA 348

<210>26

<211>3561

<212>DNA

<213>HELICOBACTER?PYLORI

<400>26

ATGACTAACG?AAACTATTGA?TCAAACAAGA?ACACCAGATC?AAACACAAAG?CCAAACAGCT 60

TTTGATCCGC?AACAATTTAT?CAATAATCTT?CAAGTGGCTT?TTATTAAAGT?TGATAATGTT 120

GTCGCTTCAT?TTGATCCTGA?TCAAAAACCA?ATCGTTGATA?AGAACGATAG?GGATAACAGG 180

CAAGCTTTTG?ATGGAATCTC?GCAATTAAGG?GAAGAATACT?CCAATAAAGC?GATCAAAAAT 240

CCTACCAAAA?AGAATCAGTA?TTTTTCAGAC?TTTATCGATA?AGAGCAATGA?TTTAATCAAC 300

AAAGACAATC?TCATTGATGT?AGAATCTTCC?ACAAAGAGCT?TTCAGAAATT?TGGGGATCAG 360

CGTTACCAAA?TTTTCACAAG?TTGGGTGTCC?CATCAAAAAG?ATCCGTCTAA?AATCAACACC 420

CGATCGATCC?GAAATTTTAT?GGAAAATATC?ATACAACCCC?CTATCCCTGA?TGATAAAGAA 480

AAAGCAGAGT?TTTTGAAATC?TGCCAAACAA?TCTTTTGCAG?GAATCATTAT?AGGGAATCAA 540

ATCCGAACGG?ATCAAAAGTT?CATGGGCGTG?TTTGATGAAT?CCTTGAAAGA?AAGGCAAGAA 600

GCAGAAAAAA?ATGGAGGGCC?TACTGGTGGG?GATTGGTTGG?ATATTTTTCT?CTCATTTATA 660

TTTAACAAAA?AACAATCTTC?CGATGTCAAA?GAAGCAATCA?ATCAAGAACC?AGTTCCCCAT 720

GTCCAACCAG?ATATAGCCAC?TACTACCACC?GACATACAAG?GCTTACCGCC?TGAAGCTAGG 780

GATTTACTTG?ATGAAAGGGG?TAATTTTTCT?AAATTCACTC?TTGGCGATAT?GGAAATGTTA 840

GATGTTGAGG?GAGTCGCTGA?CATTGATCCT?AATTACAAGT?TCAATCAATT?ATTGATTCAC 900

AATAACGCTC?TGTCTTCTGT?GTTAATGGGG?AGTCATAATG?GCATAGAACC?TGAAAAAGTT 960

TCATTATTGT?ATGCGGGCAA?TGGTGGTTTT?GGAGACAAAC?ACGATTGGAA?CGCCACCGTT 1020

GGTTATAAAG?ACCAACAAGG?TAACAATGTG?GCTACACTCA?TTAATGTGCA?TATGAAAAAC 1080

GGCAGTGGCT?TAGTCATAGC?AGGTGGTGAG?AAAGGGATTA?ATAACCCTAG?TTTTTATCTC 1140

TACAAAGAAG?ACCAACTCAC?AGGCTCACAA?CGAGCATTGA?GTCAAGAAGA?GATCCGAAAC 1200

AAAGTAGATT?TCATGGAATT?TCTTGCACAA?AATAATACTA?AATTAGACAA?CTTGAGCGAG 1260

AAAGAGAAAG?AAAAATTCCA?AAATGAGATT?GAAGATTTTC?AAAAAGACTC?TAAGGCTTAT 1320

TTAGACGCCC?TAGGGAATGA?TCGTATTGCT?TTTGTTTCTA?AAAAAGACAC?AAAACATTCA 1380

GCTTTAATTA?CTGAGTTTAA?TAATGGGGAT?TTGAGCTACA?CTCTCAAAGA?TTATGGGAAA 1440

AAAGCAGATA?AAGCTTTAGA?TAGGGAGAAA?AATGTTACTC?TTCAAGGTAG?CCTAAAACAT 1500

GATGGCGTGA?TGTTTGTTGA?TTATTCTAAT?TTCAAATACA?CCAACGCCTC?CAAGAATCCC 1560

AATAAGGGTG?TAGGCGCTAC?GAATGGCGTT?TCCCATTTAG?AAGCAGGCTT?TAACAAGGTA 1620

GCTGTCTTTA?ATTTGCCTGA?TTTAAATAAT?CTCGCTATCA?CTAGTTTCGT?AAGGCGGAAT 1680

TTAGAGAATA?AACTAACCGC?TAAAGGATTG?TCCCTACAAG?AAGCTAATAA?GCTCATCAAA 1740

GACTTTTTGA?GCAGCAACAA?AGAATTGGCT?GGAAAAGCTT?TAAACTTCAA?TAAAGCTGTA 1800

GCTGAAGCTA?AAAGCACAGG?CAACTATGAC?GAGGTGAAAA?AAGCTCAGAA?AGATCTTGAA 1860

AAATCCCTAA?GGAAACGAGA?GCATTTGGAG?AAAGAAGTAG?AGAAAAAATT?GGAGAGCAAA 1920

AGCGGCAACA?AAAATAAAAT?GGAAGCAAAA?GCTCAAGCTA?ACAGCCAAAA?AGATGAGATT 1980

TTTGCGTTGA?TCAATAAAGA?GGCTAATAGG?GATGCAAGAG?CAATCGCTTA?CACTCAAAAT 2040

CTTAAAGGCA?TCAAAAGGGA?ATTGTCTGAT?AAACTTGAAA?AAATCAGCAA?GGATTTGAAA 2100

GACTTTAGTA?AATCTTTTGA?TGAATTCAAA?AATGGCAAAA?ATAAGGATTT?CAGCAAGGCA 2160

GAAGAAACGC?TAAAAGCCCT?TAAAGGCTCG?GTGAAAGATT?TAGGTATCAA?TCCAGAATGG 2220

ATTTCAAAAG?TTGAAAACCT?TAATGCAGCT?TTGAATGAAT?TCAAAAATGG?CAAAAATAAG 2280

GATTTCAGCA?AGGTAACGCA?AGCAAAAAGC?GACCTTGAAA?ATTCCGTTAA?AGATGTGATC 2340

ATCAATCAAA?AGGTAACGGA?TAAAGTTGAC?AATCTCAATC?AAGCGGTATC?AGTGGCTAAA 2400

GCAATGGGCG?ATTTCAGTAG?GGTAGAGCAA?GTGTTAGCCG?ATCTCAAAAA?CTTCTCAAAG 2460

GAGCAATTGG?CTCAACAAGC?TCAAAAAAAT?GAAGATTTCA?ATACTGGAAA?AAATTCTGAA 2520

CTATACCAAT?CCGTTAAGAA?TAGTGTAAAT?AAAACCCTAG?TCGGTAATGG?GTTATCTGGA 2580

ATAGAGGCCA?CAGCTCTCGC?CAAAAATTTT?TCGGATATCA?AGAAAGAATT?GAATGAGAAA 2640

TTTAAAAATT?TCAATAACAA?TAATAATGGA?CTCAAAAACA?GCACAGAACC?CATTTATGCT 2700

AAAGTTAATA?AAAAGAAAAC?AGGACAAGTA?GCTAGCCCTG?AAGAACCCAT?TTATACTCAA 2760

GTTGCTAAAA?AGGTAAATGC?AAAAATTGAC?CGACTCAATC?AAATAGCAAG?TGGTTTGGGT 2820

GGTGTAGGGC?AAGCAGCGGG?CTTCCCTTTG?AAAAGGCATG?ATAAAGTTGA?TGATCTCAGT 2880

AAGGTAGGGC?TTTCAGCTAG?CCCTGAACCC?ATTTACGCTA?CGATTGATGA?TCTCGGCGGA 2940

CCTTTCCCTT?TGAAAAGGCA?TGATAAAGTT?GATGATCTCA?GTAAGGTAGG?GCGATCAAGG 3000

AATCAAGAAT?TGGCTCAGAA?AATTGACAAT?CTCAATCAAG?CGGTATCAGA?AGCTAAAGCA 3060

GGTTTTTTTG?GCAACCTAGA?GCAAACGATA?GACAAGCTCA?AAGATTCTAC?AAAAAAGAAT 3120

GTTATGAATC?TATATGTTGA?AAGTGCAAAA?AAAGTGCCTG?CTAGTTTGTC?AGCGAAATTG 3180

GACAATTATG?CTATTAACAG?CCACACACGC?ATTAATAGCA?ATATCCAAAA?TGGAGCAATC 3240

AATGAAAAAG?CGACCGGTAT?GCTAACGCAA?AAAAACCCTG?AGTGGCTTAA?GCTCGTGAAT 3300

GATAAGATAG?TTGCGCATAA?TGTGGGAAGC?GTTTCTTTGT?CAGAGTATGA?TAAAATTGGC 3360

TTCAACCAGA?AGAATATGAA?AGATTATTCT?GATTCGTTCA?AGTTTTCCAC?CAAGTTGAAC 3420

AATGCTGTAA?AAGACATTAA?GTCTGGCTTT?ACGCACTTTT?TAGCCAATGC?ATTTTCTACA 3480

GGATATTACT?GCTTGGCGAG?GGAAAATGCG?GAGCATGGAA?TCAAAAATGT?TAATACAAAA 3540

GGTGGTTTCC?AAAAATCTTA?A 3561

<210>27

<211>70

<212>DNA

<213>OLIGO

<400>27

GCAGGGGTTT?TATGTTGTGT?CTTGAGCGGT?GCTATGGGGA?TTGTTGGGAT?AATCTTTGTC 60

GCAATAGGAA 70

<210>28

<211>70

<212>DNA

<213>OLIGO

<400>28

TTATGTAAAT?AAAGGCGGCT?GTAAGGGCGT?TTTACGAGAA?ATAAATGGCT?CAATGAAAAT 60

GGTTTGCTTG 70

<210>29

<211>70

<212>DNA

<213>OLIGO

<400>29

ATGTTTAGAA?AACTAGCAAC?CGCTGTATCG?CTCATAGGCT?TACTAACCTC?TAACACTCTT 60

TATGCTAAAG 70

<210>30

<211>70

<212>DNA

<213>OLIGO

<400>30

CAACAAAAGC?GTGTATCAAT?TAGTAGAAAT?GGCAATAGGC?GCTTACAATG?GGGGAATGAA 60

ACACAACCCT 70

<210>31

<211>70

<212>DNA

<213>OLIGO

<400>31

TTTCATTCCG?TTCTTTCAGC?AATCGGTTAT?ACTCTTGCCT?TATTTGGATT?TCATCATTGA 60

CATAAAGATT 70

<210>32

<211>70

<212>DNA

<213>OLIGO

<400>32

GCAGGTTGGA?GAGTGATGTT?TTTGAAACCA?AAATAAGTGA?ATGTGCCATC?ATCAAAAATT 60

TCAGAGGGCA 70

<210>33

<211>70

<212>DNA

<213>OLIGO

<400>33

TTTACAGGTT?TATCCAGTGA?TTTGTTTTCT?ATGATATTAA?ATTTTTTGTT?CTTCCTGATG 60

TTAATGATGG 70

<210>34

<211>70

<212>DNA

<213>OLIGO

<400>34

CTTATAATAA?AACCTAGCTT?TTTTTATTAC?ACTACTTATC?TTTTGCTACT?CGTTTCTCTC 60

AGCATAATAA 70

<210>35

<211>70

<212>DNA

<213>OLIGO

<400>35

CTACCACTAA?AGATAAGGCT?CAGGCTTTGC?TTCAAATGGG?TGTGTTTTCT?TTAGATGAAG 60

AACAAAACAA 70

<210>36

<211>70

<212>DNA

<213>OLIGO

<400>36

TTGAAAAGTA?TCTTCAAAAA?ACTAGGTTCT?GTCGCTCTTT?ATTCTTTAGT?TATTTATGGG 60

GGCTTAAACG 70

<210>37

<211>70

<212>DNA

<213>OLIGO

<400>37

GAGCGTTAAA?CATGCCAATG?ATAAGACACC?AAGCAAATAG?TAATTTAATT?TTATAAAAAT 60

TCGTTTTCAT 70

<210>38

<211>70

<212>DNA

<213>OLIGO

<400>38

GGACTCTATT?GACAATCACG?AAGTCAAAAA?CTTCATCTTT?GATAATATCG?GGATTGACTT 60

CTTTGAAAGT 70

<210>39

<211>70

<212>DNA

<213>OLIGO

<400>39

ATCACTGACA?GCTACAAGAA?AGTTGTAGTA?ACTTTAGGGC?TAGTGGTAAC?AACCAATCCT 60

TTAATGGCGG 70

<210>40

<211>70

<212>DNA

<213>OLIGO

<400>40

AGCTTTGAAT?GAATTCAAAA?ATGGCAAAAA?TAAGGATTTC?AGCAAGGTAA?CGCAAGCAAA 60

AAGCGACCTT 70

<210>41

<211>22

<212>DNA

＜213〉primer

<400>41

ATGATACAAA?GAGGATTGAG?TA 22

<210>42

<211>21

<212>DNA

＜213〉primer

<400>42

GCTAAAGAAA?TAAGTGAAGC?C 21

<210>43

<211>20

<212>DNA

＜213〉primer

<400>43

TGGATTGGTC?TGACTTTGCT 20

<210>44

<211>20

<212>DNA

＜213〉primer

<400>44

ACAATGGGGG?AATGAAACAC 20

<210>45

<211>20

<212>DNA

＜213〉primer

<400>45

TTCTAAAGAA?GTGAGATAAG 20

<210>46

<211>18

<212>DNA

＜213〉primer

<400>46

AAATTCCCCA?CTCTTTTC 18

<210>47

<211>18

<212>DNA

＜213〉primer

<400>47

GCAAGTCTTG?GGGAATAT 18

<210>48

<211>23

<212>DNA

＜213〉primer

<400>48

ACGCCTTTTT?ATTTATCTCT?GAC 23

<210>49

<211>20

<212>DNA

＜213〉primer

<400>49

TAAAAAATGC?CTGCCCCATC 20

<210>50

<211>20

<212>DNA

＜213〉primer

<400>50

TTCGCTTACC?GTCTGTTCGT 20

<210>51

<211>20

<212>DNA

＜213〉primer

<400>51

CCACCTAGCA?ACTCACAGAG 20

<210>52

<211>20

<212>DNA

＜213〉primer

<400>52

GATACCCTTA?AATGACAAAC 20

<210>53

<211>20

<212>DNA

＜213〉primer

<400>53

TTCATCAGCA?AATCCCTAAC 20

<210>54

<211>20

<212>DNA

＜213〉primer

<400>54

TACCAAAACC?ATTACCAACC 20

<210>55

<211>22

<212>DNA

＜213〉primer

<400>55

AACGAGATAA?AAAAAGAACA?AG 22

<210>56

<211>23

<212>DNA

＜213〉primer

<400>56

CGCTAACCCT?TTGAATGACA?ACC 23

<210>57

<211>20

<212>DNA

＜213〉primer

<400>57

GGTATTGTCG?CTTACTTTGT 20

<210>58

<211>20

<212>DNA

＜213〉primer

<400>68

GTTTCTTGCT?GTCGTTTCTC 20

<210>59

<211>22

<212>DNA

＜213〉primer

<400>19

GTAATCAAGA?TAAGTCAAAT?GC 22

<210>60

<211>22

<212>DNA

＜213〉primer

<400>60

CGATGAATCT?GGATATGTTG?GT 22

<210>61

<211>18

<212>DNA

＜213〉primer

<400>61

ATGCGTGAAG?TCATAGGC 18

<210>62

<211>20

<212>DNA

＜213〉primer

<400>62

TAAACTTCTT?TCACCCCACC 20

<210>63

<211>23

<212>DNA

＜213〉primer

<400>63

TGCCGCTGCA?AGCGTATTAG?AAT 23

<210>64

<211>21

<212>DNA

＜213〉primer

<400>64

GCTTCACATG?TAATCGTATA?A 21

<210>65

<211>18

<212>DNA

＜213〉primer

<400>65

GCCAAACTTA?GTGCTCAA 18

<210>66

<211>22

<212>DNA

＜213〉primer

<400>66

GCCACTACTA?CCACCGACAT?AC 22

<210>67

<211>20

<212>DNA

＜213〉primer

<400>67

GGGCGATTTC?AGTAGGGTAG 20

<210>68

<211>22

<212>DNA

＜213〉primer

<400>68

GCCACTACTA?CCACCGACAT?AC 22

<210>69

<211>20

<212>DNA

＜213〉primer

<400>69

GGGCGATTTC?AGTAGGGTAG 20

<210>70

<211>22

<212>DNA

＜213〉primer

<400>70

GCCACTACTA?CCACCGACAT?AC 22

<210>71

<211>20

<212>DNA

＜213〉primer

<400>71

ACCAACGCCT?CCAAGAATCC 20

<210>72

<211>20

<212>DNA

＜213〉primer

<400>72

ATCAATACAA?CTGAAGCAAC 20

<210>73

<211>20

<212>DNA

＜213〉primer

<400>73

ATCGCTTGTT?CTTTGTTGTC 20

<210>74

<211>20

<212>DNA

＜213〉primer

<400>74

TTGCCTTTTT?CATTCCGTTC 20

<210>75

<211>20

<212>DNA

＜213〉primer

<400>75

TCTGCTCGGA?CTTTATCTAC 20

<210>76

<211>20

<212>DNA

＜213〉primer

<400>76

ATGTTGCCAA?GAATAATCCC 20

<210>77

<211>20

<212>DNA

＜213〉primer

<400>77

ATACCGCTCA?TCATTTCAAC 20

<210>78

<211>20

<212>DNA

＜213〉primer

<400>78

TAAACTTCTT?TCACCCCACC 20

<210>79

<211>18

<212>DNA

＜213〉primer

<400>79

TTCAATCCAT?TGCATTTG 18

<210>80

<211>21

<212>DNA

＜213〉primer

<400>80

TCTCCTTATC?CACTAATAAC?C 21

<210>81

<211>20

<212>DNA

＜213〉primer

<400>81

GTTTCATTCC?CCCATTGTAA 20

<210>82

<211>21

<212>DNA

＜213〉primer

<400>82

AGGTGAAGAA?GATAAGAGTG?G 21

<210>83

<211>20

<212>DNA

＜213〉primer

<400>83

CAAATGAAGT?AAAGGATAAG 20

<210>84

<211>18

<212>DNA

＜213〉primer

<400>84

AGCGAAAGAA?CTCCAACA 18

<210>85

<211>18

<212>DNA

＜213〉primer

<400>85

TGGCATTGTA?GTCGCTGT 18

<210>86

<211>21

<212>DNA

＜213〉primer

<400>86

CAAAAAAGCC?CTGAGGATAA?C 21

<210>87

<211>20

<212>DNA

＜213〉primer

<400>87

GTTGAGGACA?ATGTGAAAGG 20

<210>88

<211>20

<212>DNA

＜213〉primer

<400>88

GGGGTGTGAT?AGCCCTTGAT 20

<210>89

<211>20

<212>DNA

＜213〉primer

<400>89

TAAATCAAAT?AGCCCATACC 20

<210>90

<211>20

<212>DNA

＜213〉primer

<400>90

CACTTACCAC?TGAGCAAACT 20

<210>91

<211>20

<212>DNA

＜213〉primer

<400>91

AACATGCGAA?AACTCTTCTC 20

<210>92

<211>20

<212>DNA

＜213〉primer

<400>92

TGCTTCCTAC?TAAAACACGC 20

<210>93

<211>23

<212>DNA

＜213〉primer

<400>93

ACGCCAAGCG?TTCCGAGTTA?AAA 23

<210>94

<211>22

<212>DNA

＜213〉primer

<400>94

GACGCTATTG?GGCAGTTCAG?AT 22

<210>95

<211>20

<212>DNA

＜213〉primer

<400>95

TTTTTTGCTC?TTGTCTGTTT 20

<210>96

<211>20

<212>DNA

＜213〉primer

<400>96

CACAAGCCAA?ACAAAAAACC 20

<210>97

<211>18

<212>DNA

＜213〉primer

<400>97

AGGAATAGTA?GCGGGTGC 18

<210>98

<211>20

<212>DNA

＜213〉primer

<400>98

GCTTGGTGTC?TTATCATTGG 20

<210>99

<211>20

<212>DNA

＜213〉primer

<400>99

GAAAATGATG?TCTTGACGAT 20

<210>100

<211>27

<212>DNA

＜213〉primer

<400>100

AAAAAAATAG?AAGAACTTAA?AGCAGAC 27

<210>101

<211>20

<212>DNA

＜213〉primer

<400>101

TTTTTCGCCA?AACATTGCTC 20

<210>102

<211>18

<212>DNA

＜213〉primer

<400>102

CTCGTTGTTT?TCAGTTCG 18

<210>103

<211>21

<212>DNA

＜213〉primer

<400>103

TTACAAGAAT?CACTGACAGC?T 21

<210>104

<211>22

<212>DNA

＜213〉primer

<400>104

AGAGTGGTTT?TTGTCTCCCC?AT 22

<210>105

<211>20

<212>DNA

＜213〉primer

<400>105

GACAAAGAAA?CGCTTCCCAC 20

<210>106

<211>22

<212>DNA

＜213〉primer

<400>106

AGAGTGGTTT?TTGTCTCCCC?AT 22

<210>107

<211>20

<212>DNA

＜213〉primer

<400>107

GACAAAGAAA?CGCTTCCCAC 20

<210>108

<211>20

<212>DNA

＜213〉primer

<400>108

CTGACAAAGA?AACGCTTCCC 20

<210>109

<211>20

<212>DNA

＜213〉primer

<400>109

CTGACAAAGA?AACGCTTCCC 20

<210>110

<211>20

<212>DNA

＜213〉primer

<400>110

GCAAGAAATA?CAAATTGGGG 20

<210>111

<211>22

<212>DNA

＜213〉primer

<400>111

CGAAAAAAAA?CCAAGCAAAA?AC 22

<210>112

<211>24

<212>DNA

＜213〉primer

<400>112

GATAGAGAAA?GAGATGCCTT?AATG 24

<210>113

<211>20

<212>DNA

＜213〉primer

<400>113

CTTTCTTCAG?TAAGCCTATC 20

<210>114

<211>20

<212>DNA

＜213〉primer

<400>114

CACAAGCCAA?ACAAAAAACC 20

<210>115

<211>22

<212>DNA

＜213〉primer

<400>115

AACAAAATAT?ACCCAACCAA?TC 22

<210>116

<211>20

<212>DNA

＜213〉primer

<400>116

AGTCTCGTTG?TTTTCAGTTC 20

<210>117

<211>11770

<212>DNA

<213>H.pylori

<400>117

TCTTGGCTGT?GAGTAAGTAT?TGACACCGCT?ACGCATAAGC?AGGTTTTGCA?AAAATTGCAA 60

GAGTATCAAC?AATACGCTTC?GCAATTTTTA?GCTCTAGTGC?CTTTGAGCGC?GAAAAAATCT 120

CAAAATTTAA?ACGCGCTTTT?AGAATGCATC?AGCAAGCATT?TAAGCCCTAG?TGCATGGCTT 180

TTTGAAAAGG?ATTTGATGAG?CGATGAAAAA?ATGCGCGATA?TTTATAAGGA?AATCATTAGG 240

GAGAGTTTGT?TTGATTTTTT?GAGCGATGAG?ATCCCTTATG?AAAGCGATGT?GGTAATTGAT 300

AAATTTATAG?AAGAAGAACG?CATAGACAAG?GTGTATGCGC?ATATTATCGT?AGAAAAAGAA 360

AGCCAAAAAA?AAATCGTGAT?AGGCAAAAAC?GGGGTGAATA?TCAAACGCAT?CGGGACTAGC 420

GCGCGATTGA?AAATGCAAGA?AGTGGGCGAA?AAAAAGGTTT?TTTTAAACTT?GCAAGTGATC 480

GCTCAAAAAT?CATGGAGCAA?GGAAGAAAAG?AGCTTGCAAA?AACTGGGTTA?TATCTATCAA 540

AGGAATAGGG?ATTGAAAAAA?ATATTATCGG?CTCTGTTAAT?GGGGTTTGTG?GGCTTGAATG 600

CTGATGATCG?CTTGTTAGAA?ATTGTGCATC?TTTATCAAAA?ACAAGGCTTG?GAAGTGGTGG 660

GTCAAAAGCT?GGATTCTTAT?TTAGCGGATA?AATCTTTTTG?GGCAGAAGAG?CTTCAAAATA 720

AGGACACGGA?TTTTGGCTAT?TATCAAAACA?AGCAGTTTTT?ATTTGTGGCG?GATAAATCCA 780

AGCCTAGTTT?AGAGTTTTAT?GAAATAGACA?ACAACATGCT?TAAAAAAATC?AACAGCTCTA 840

AAGCCCTTGT?AGGCTCTAAA?AAGGGCGATA?AAACTTTAGA?GGGCGATTTG?GCAACGCCTA 900

TTGGAGTGTA?TCGTATCACG?CAGAAATTAG?AGCGCTTGGA?TCAATATTAT?GGCGTTTTGG 960

CTTTTGTAAC?GAATTACCCT?AATTTGTATG?ACACCTTGAA?AAAACGCACC?GGGCATGGCA 1020

TTTGGGTGCA?TGGAATGCCT?TTAAATGGCG?ATCGGAATGA?ATTGAACACC?AAGGGCTGCA 1080

TTGCGATTGA?AAACCCGCTT?TTAAGCTCTT?ATGATAAAGT?GTTAAAAGGC?GAAAAAGCGT 1140

TCCTTATCAC?CTATGAAGAC?AAGTTTTTCC?CCAGCACTAA?AGAAGAATTG?AGCATGGTTT 1200

TAAGCTCCCT?TTTTCAATGG?AAAGAAGCCT?GGGCTAGGGG?CGATTTTGAA?GGCTACATGC 1260

GTTTTTATAA?CCCCAACTTC?ACTCGCTATG?ACGGCATGAA?ATTCAACGCT?TTTAAAGAGT 1320

ATAAAAAAAG?GGTGTTTGCC?GAAAAACGAA?AAAAAGAATA?TCGCTTTTCT?TCTATCAATG 1380

TGATCCCTTA?CCCCAATTCC?CAGAACAAAC?GCTTGTTTTA?TGTGGCGTTT?GACCAAGAAT 1440

TACAAAGCCT?ACCAGCAAAA?CAAGCTCTCT?TATAGCTCTA?ATTCTCAAAA?AGAACTCTAT 1500

GTAGAGATTG?AAAACAATCA?AGTGTCTATT?ATAATGGAAA?AATAGGGTTT?TGCTTTAATG 1560

AGAGTCTAAA?CGGATTTTTA?ACCCATTCAG?TCAAGCTTGA?TACAAATTTT?ATTAAAAACT 1620

ACAGAGCTTC?CATGGCTTTT?TCATAGCCAA?ATTCTGCGGA?TTTTTGCAAG?AATTTTTTAG 1680

CCTTCTCCTT?TTTCCTTCTA?GTGCCAAGCC?CTTCTTTATA?AGCGATCCCA?ATCCTATAAA 1740

GGATCTCCCC?CATTTGTTGT?TTGAGTAAAG?TAATATTGCT?TGAAATTTCA?GCAATATCTT 1800

CCCAAAGAAG?TGTCTTATCT?TTGATTTGAG?TGGATTTCTT?AACAAGTATT?CCAAACTTCT 1860

TTCCAAATTT?TATAGGATTC?GCGCTCAAAC?CTGAAAGATC?AATGAATCGC?GATCCAATAA 1920

GCATACTAGT?GAACGCAAGG?TTTGGTAATC?TAAAATTGTT?AGCAAAATAA?TTTGTGCTTT 1980

TATTAGAAAA?CATGCGAACC?ACATGCCTGT?AAGTCTTAAG?CGCTTGTTTC?AAATCCTTTT 2040

TCATCCCTAA?GCCTTGCGCT?TGCATGCGTC?CTAAAATAAG?AGCGCCCCCT?AACAACCCGC 2100

TCCCATACCC?TTTGATAGCG?TTTTGTGCAT?AGAATTGCGC?TTTTTTGTAA?TCCACTTTCA 2160

CGCCCTTTCC?CTCCAAATAC?ATTTTGGCTA?AATAAACGCT?ACCAAGCCCA?ATGCTGTATT 2220

CTTGCGCCAA?TCTAAAATCT?TTAAAGGCTT?GCTTGTATTG?GCCTTGATTA?AAATGGTCTA 2280

AACCATTTTC?AAAATAATAT?GTCTTATGAT?TTCGCGCAAT?TTCATCCCAT?TGATTTCGTG 2340

CCCTTTCATC?CCAATCATCA?CTTATGCTAA?TATATTCACC?AGCTATACAA?AGCGAAAATG 2400

GCAATAATAA?ACACAATAAA?AGCAATAAAG?GCTTTAAAAA?AGAAAAAGTG?GTGCGATAAA 2460

AATCTTTAAA?CATGTCAGAT?CCTTTTACAA?TTTGAGCCAT?TCTTTATAGC?ATAATAGTAA 2520

CATGGAGATG?GTTTTATATT?TTTTGCTATA?ATAAAATGAA?TTTGTTTCAT?AGTAACAAAT 2580

TGAGAATATA?CCATTATGGA?GGTAACACTA?TGGCTGACAC?AATCAATACA?ACTGAAGCAA 2640

CCCATGAAAC?AAAAAAGCCA?AACGCTTTTG?TAAATTTTTT?CAAAAACAGT?TTGACTGATA 2700

AGCGTTATGA?TTCATTAGGT?CTCATTGGAG?CAGGGGTTTT?ATGTTGTGTC?TTGAGCGGTG 2760

CTATGGGGAT?TGTTGGGATA?ATCTTTGTCG?CAATAGGAAT?CTTTTTGTCT?TTTTCTAATA 2820

TCAACTTAGT?GAAATTAGTT?GAAAAATTGT?CCAAAAAGCA?ATCTAAAGCG?GCAACAACTG 2880

TCAATAACGA?AACCCAAAAA?TCTCAAGCAA?CAAGCGTTAC?CAACGAACCA?ACTGAAGCTA 2940

AAGAGACTAA?AGATTGAGGC?AAAACAACGA?TTTTGACTAA?AAGAAAGAAT?AAGAGAAAAT 3000

TTCAAAAGTT?TAGGTGTTCT?AGTGGTTTAT?TACTCACTGC?ATGACTCACA?CAAGCGGTCT 3060

ATAAATTCTT?TTTTTAGATT?TAAGAATGGT?TATTTGCAAT?ATGAGTCTAG?CTACGAGTTG 3120

GTGGGGTTGA?TTAAATCCAT?TGGCAAGGCT?TTAAAAATGG?AAACCAACTG?AAAAAAAGGA 3180

AACTAATGTT?TAGAAAACTA?GCAACCGCTG?TATCGCTCAT?AGGCTTACTA?ACCTCTAACA 3240

CTCTTTATGC?TAAAGAAATA?AGTGAAGCCG?ATAAGGTCAT?TAAGGCCACT?AAAGAAACTA 3300

AAGAAACCAA?GAAAGAAGCT?AAACGACTCA?AAAAAGAAGC?CAGACGGCAC?CAACAGATCC 3360

CTGATCATAA?GAAACCTCAA?TATGTTTCTG?TTGATGACAC?AAAAACTCAG?GCGCTTTTTG 3420

ATATATACGA?CACCTTGAAT?GTGAATGACA?AAAGCTTTGG?GGATTGGTTT?GGCAATAGTG 3480

CTTTGAAAGA?CAAAACCTAT?CTCTACGCTA?TGGATCTATT?GGATTACAAC?AACTATCTAT 3540

CCATAGAAAA?CCCCATTATC?AAAACAAGAG?CGGTGGGAAC?CTATGCGGAT?CTCATCATCA 3600

TCACAGGCTC?ACTAGAACAA?GTCAATGGGT?ATTACAACAT?TCTAAAAGCG?CTCAACAAAC 3660

GAGACGCTAA?GTTTGTCTTA?AAAATCAATG?AAAACCTGCC?TTACGCCCAA?GCGACTTTTT 3720

TGAGAGTGCC?AAAAAGAAGC?GATCCCAATG?CCCATACGCT?TGATAAGGGA?GCGTCAATTG 3780

ATGAGAATAA?GCTTTTTGAA?CAACAGAAAC?GCGCGTATTT?CAAGTACGCC?CACGATGTGA 3840

TCTGCAGACC?CAATGATGAA?GTGTGTTCGC?CTTTGAGAGA?TGCAATGGTA?GCTATGCCCA 3900

CTAGCGATAG?CTACTACTCA?AAAACCTAAG?ATCATTGCTC?CTTATAGTTT?GTATAGACTA 3960

AAGAGACAAA?TAGCGCTAAT?GAGGCTCAAC?CATCGCCTTA?GGCCACTCAA?ACCGCTCCTG 4020

AAAACAGCAA?AGAGAAGCTC?ATAGAAGAGC?TTATCGCTAC?TCCCAACTCA?TAGCCAATGA 4080

AGAAGAGAGG?GGAAAAGAAA?TCTTAGCAGA?TAAAGAAAAA?CAAGAGGCTG?AATTGGCTAA 4140

ATACAAGCTC?AAAGACTTAG?AAAATCAAAA?GAAACTAAAA?GCTTTAGAAG?CAGAGTTGAA 4200

AAAGAAAAAT?GCTAAGAAAC?CTAGAGTAGT?GGAAGTGCCT?ATTTCTCCTA?GAACAAGTAA 4260

TCCTGATGAA?ACAATGAGAG?TTGTCAAGGA?AAAAGAAAAC?TATAATGGAT?TGTTAGTGGA 4320

TAAAGAAACC?ACGATCAAAC?GAAGCTATCA?AGGGACTTTG?ATTAGTGAAA?ATTCTTACAG 4380

CAAAAAAACA?CCTCTCAACC?CTAATGACTT?GAGAAGCTTA?GAAGAAGAAA?TTAAGAGCTA 4440

CTATATTAAG?TCTAATGGCT?TATGTTATAC?TAATGGCATC?AGTCTCTATG?TCAAAATCAA 4500

AAATGACCCC?TATAAAGAGG?GAATGCTGTG?TGGCTATGAG?AGTATTCAAA?ATCTGCTCTC 4560

ACCTCTAAAG?GACAAGCTCA?AGTACGACAA?GCAAAAATTA?CAAAAAGCGT?TACTGAAAGA 4620

TTCAAAGTAA?GTTAAAGTTT?TGTTTGGGAA?ATGGATTGGT?CTCTTTTTAC?TTCTTAATTC 4680

CTTAGCCTAT?CCATGCCAAA?AAGTAACCAT?TATTTCAAGC?AGTATGAGAA?TCTTATCCAT 4740

ATTCACCAAA?AAGGTTGCAA?CAATGAAGTG?GTGTGCAGAA?CGCTCATCTC?TATCGCCTTA 4800

TTGGAAAAGT?TCTTTAGGGT?TGAACAACAA?GCGCGAAATT?TCCCTAAAAG?ACACTTCCTA 4860

TTCCATGTTT?CACATCACTT?GGACACCGCT?AAAAAATTCT?ACCCCACCTA?TTCTAAAACG 4920

CTTCTCAAAT?ACAAATTGCT?CAATGATGTG?GATTTTGCGA?TTCATGGGCT?AAAAGAATTT 4980

TGAAAGAAAA?TTTTGATTAT?TACAAACAAA?AACACCCTAA?TAAAAGCGTG?TATCAATTAG 5040

TAGAAATGGC?AGTAGGCGCT?TACAATGGGG?GAATGAAACA?CAACCCTAAT?GGCACTTATG 5100

TGAAAAAGTT?CCGCTGTGTC?TATTCTCAGG?TGCGCTACAA?CGAGTAGGGC?ATACTAATTT 5160

TACAAGCAAT?CTTGATGATA?TACTTCTACG?ATCTTATGAA?TTTATAATAA?TATCATTTAC 5220

ATCATTATCT?TTTAATTTTT?CTAAAATATA?TTTCGCTTCT?TTTTGTTAAG?ATATTTTGTC 5280

TTTTTATTTT?TTGGAATAGG?CTTTTTGCTT?TCCTTATAAG?GACATATAGC?GTAAAAATTT 5340

TTCCAATTCA?TACGATTTTG?GCATAGGTGC?TGTAAAAATG?GATTGATGAA?TTTTAACCTA 5400

GTGCATGCAA?ACAATCCACT?AGAGCGATGG?TTGGCAAATC?AAAGAACACA?CAAATCACAG 5460

TTCGCTTGAA?CCCACAGGCA?CTAAAGATTT?ATCATAACTC?AATTCGCCTC?TGGTTTTAGC 5520

GGCTTGCAAA?TCATCATAAA?AAGTCGTCTG?ATCAGGCACT?TTCCCCAATT?TGTATTTCTT 5580

GCTCAAACTT?GGACTCACCT?TAATGAGTTC?ATCGGTGAAG?AAAGGATCAT?CGTAGTAAAG 5640

CGCCTTGTGG?CACTTGATGG?GTTTGAGCGT?GTTTTCTAGA?ATGATAAGCT?CATCGCCCAT 5700

AGTCATCAAT?TCATCAGGGG?TCATCAAAAA?GCGCTCTTTG?TTGCTGATAG?AAGTGTTGGT 5760

CTTACCGGTA?TTATCATCAA?TGCTTCGGCT?CACATCTTGC?CTTGTGTATT?TCCCTAACAC 5820

CTTAGAAAGT?TTTTCAAAAT?GTTCATAGTA?GTTATCGTTG?TTAATCCCAT?AATACATATT 5880

CAAAGAAAGG?TTGTCTAAAA?TAGTCTTAGC?ACCATTCCTA?CCATAACCAA?GTGGGGGGTC 5940

ATTCTCTAGT?TGCGCCTTAC?TTTGAAACAC?AAACGCAGGG?CGCATGTTGT?ATTCTGCCAT 6000

GATCCCTACC?GCTTTAACAA?AGGTCTCTAA?ATAGCCACAA?AGCGTAAATT?CGTCCATGAG 6060

CATTAAACAA?CTTCTTTTGC?ATTGTGGATC?ATGGATTGGC?AGAATAAGGT?TGCTATAAAT 6120

CATCACATTG?AAAAACAGCT?CTAATATCGG?CCCAACAATA?GTGCTTTCTT?TAGGATTAGC 6180

GATCACGCCA?ATACTCACTT?CATCAATCCT?TAAACGCCTG?AAATCAAAAT?CATTAGCGCT 6240

CGTGAAATTT?CTGATCATGG?CGTTATTGTA?GGGGGCAAAC?GCTGAAGTAT?AGACCCCTTG 6300

AACAGAGCTG?TAAGTTTCTT?TAGCGCCGCC?CATTGTCTTG?AAATTATTCC?ACATGTTTCT 6360

AGTGGCAGGA?CTAAGCACTC?TTATATTATC?GCCACTCTTA?TCTTCTTCAC?CTCCAAAAAA 6420

TTCCATCAGA?GACACGACTT?TTTCCATGTT?TGTGTCTTCA?TCAATCAAGT?TGATACCGCT 6480

TGCCATAGAA?CCTATGAAAA?ACATCGTGGG?GGTTTCAGGC?ATGATGATTT?TTTTTCTTTT 6540

GACAAACTCA?AGTCCCTTTT?TAGTCCACAT?GAGATCTCTA?TAAATATTGC?AATTGATGAC 6600

AAAAAGATTT?CGCGCTTGAT?TGCTAAAAAA?AGGATCTTTT?TCATTAGGTC?TTTCAGGGAA 6660

CACGAGCTTT?GCCAATCCAA?AGATTTGAGT?GGAAAAATCC?CCCCCACTAG?CCACCATCCC 6720

ATGACCTTTT?AGGCGTGTGT?CAATTTGAGA?GAGTATGTCT?TCAGTTAAAA?CCACATCATT 6780

ACCAAAATCC?ACATAAGCGA?AAGGATTAAA?TCGGTGTGTT?TTTAAGGAGA?AAGGTTCATA 6840

GATATACACT?TTTTGGTTGA?AGCAGTTTTT?CTCTGATTTT?TCCGCAAGTT?TCCATAGTGT 6900

CAGCCTTAGG?GTCAAACACA?ACGATATTTT?GAGGATAATT?GATCATATTA?GGCATGATGA 6960

AACCCACCCC?CTTACCGCTT?CTGGTAGGAG?CAGATCAAGC?CAATGAACGC?CTGCCCTGCG 7020

TAAGCGATAA?AATCCCCCAA?ACCACGCCTG?CCAACAATAA?CTTCTCGTTT?GTCAAAGGCA 7080

GCGTTTTTTA?TTATTGGGTG?TGATAAGTTT?AGCTTTGATC?ATTTTTTCTT?CGCTCTCCCA 7140

ACTCGCGCTA?CCAAAGAGAT?CATCAACTTT?TTTATTCGCT?CCTATGTCTC?TAGTCCGAGT 7200

TAAGTATTTT?AAGAACCACA?CAAAGAAGGT?AATGAATATA?TAAGAGCATA?AAATAGAACT 7260

ATAGACGACT?AAGGATATAT?TGAACCCATA?AATCTTGAGT?GAACTAAAAC?AAAGCGCCTT 7320

AAAATAGTAT?GCAGGAAAAT?CTTGTATCGC?ATAGATCCAT?ATGTCAAAAA?GATCATCATC 7380

ACTCTCAGGC?AATTTATTAT?CATCATAAAA?ATTACCTAAT?AGGATCAAGA?AAAATAACCC 7440

TGATGTGATA?AAAGAATAGG?ATAGTAATAG?TGTAGCTTGT?AACCAAAAGC?CAAAGGTTTT 7500

AACTCTTTCT?TTCAGCCCCT?CTATAATGAT?TTCTTTAAAG?TTTTTTTTCT?TTTGAGGTTG 7560

GTTAGCTTTA?TCTTTAAAAG?CTTTTTTTTG?AGCTTTTATG?AATTTGTAGA?GAAAAAATAA 7620

CGCTATTACC?CCTATGAAAC?TAAAAATAAC?AACCAACTTA?TAATCCTCTA?TGAAATATAA 7680

GGTGTTATAC?AACAAGTCTT?CCATTGTACC?TACTACCTAT?GTTTGATATA?AAATTCATCA 7740

CACTGTTTGT?GGTGGTTGAT?ATGGACAATC?ATATCAATTA?AATCTTTAAA?GCCCTCAATG 7800

AGGCTTTCAA?ACTTGATATT?CCTTGCTGCG?TTATTAGATG?AACTCATGTT?GGCTAAACGG 7860

ATAAACGCTT?CTTCACTGCT?CCCTGCATGT?AGAGTGGTTA?GCGTGCCTTT?ATGACCGCTA 7920

CAAAGCACAT?TATAAAAATC?ATACGCCTCA?CTGCTTCTGA?GTTCTCCTAA?AATGATTCTA 7980

TCAGGCCGCA?TTCTCAAACA?TGACTTTAAA?CAATCAGCAG?AGGTGATATT?CCCACCAAAA 8040

AAAAGCTGTG?TGTAGTTCTT?GTGGTGTTTG?AATACAATCT?CTTCGGTGTC?TTCAATGGAT 8100

ATGATCCTTT?CTTCTTTGGG?GATAAACTCC?ATGATGCTTT?TGATATAAGT?CGTTTTACCG 8160

CTTCCTGTGC?CACCACAAAC?AATCACATTC?TTACCAATAG?CAATACCATC?TTTAATCGCG 8220

CTGATCGCTT?GTTCTTTGTT?ATCTAGTAGA?TTATAAAAAC?CCTGCTCTTC?AAAGAAGCTA 8280

TGAGGATAGG?TTGTTTTGCT?AGGTATCCTT?ATGGATATGG?AAATGGTTTC?ATCATTAACT 8340

GTAACAGGGG?AAAGGACAAT?CTGCACCCTT?TCACCATTCG?CTAAATTGCT?GCTCAAAATA 8400

GGATTTTCAT?AGTTGTCTAT?TGTTTTTTTC?TTAAAACTCG?CACAACACCG?AGCAAAATGC 8460

ATTAAACGAG?ACAGACTAAA?GGCTTTCTTG?TCTCTCACAT?CAAATGGTTG?CCATTCGCCA 8520

TTATTTTTTA?AAACCCATAC?AACCTTGTTC?CCATTGTAAC?AAATCTCAGT?GATATTTTCC 8580

ATTTTTAAAA?AATCACCAAA?AAGTTCTTCA?GTAGCATGCC?TTAGAGGATT?TAATGCCGCT 8640

TCTTTTAAAG?CTCTTTCCAC?TTCTAGAAAT?TTTTTATCTT?CTGCACTCAA?TCTGTCTTCA 8700

GTCATGTTCT?TATTCCAAAT?TTAATTTTAA?TTGGGTTATC?AATTTAGCTC?TTTCTAAAGA 8760

AGTGAGATAA?GTCTTATTTT?TGCTCAAAAT?AATATATTTA?GTCCCTATAT?CTTGGACAAT 8820

CTCATTGAGC?TTCCTTCCAA?AATCATCTAT?CCCTAGAATC?TGAAACGCCA?CGCCCATCAT 8880

ATTGCCATCT?ATGAATGGCG?GTAAATACTC?TCTTGGCAGA?TAAGAAGCCA?CTAGGTCTGA 8940

AATTTTTGCC?ACTTCATCAC?ACATAAAATT?ATTGAAGTTG?TCAGAAATTT?CTGCAACAAA 9000

CTCCCCAAGC?GTTAGTTCAT?TTTTGATCGT?GCTTTCTGCA?AAAGTCTTTT?CTTGTTTGCA 9060

ACGATTGTAA?CTGGCTAACA?CAAGGTTGTT?CAAATAGTTG?TAATAAGCAT?CAAAACTAAT 9120

AAAATTCTTT?TGCATATTGA?TTCTTAACTC?TTGAACTCTT?CTCAAAAAAT?CTTGCGGATC 9180

GTTGCTATCT?TTTAAAGAAA?TGGCGTAATT?TTGAATAAAC?TTATCCTTTA?CTTCATTTGC 9240

ATTTCCCATA?AGAGATCTGT?TGCTATCCAA?GATCTTTTGT?CTTTCTGCTT?CATTGAAACC 9300

GAGTTCCATT?GCTGTTTCCT?TTCATTGTTT?TTGCTTGGTT?TTTTTTCCGC?CACTACATCC 9360

TCTAGAAGAG?CCTGTTGTTG?GCTTTGTCTT?TTATTTTGTA?AAGAACCAAG?TTTGGTAACA 9420

CAGATATATT?TTATCCTTTC?TTTTGAATTA?ATTGCCACCT?TTGGGGCTTG?TGGTGATTTC 9480

TTCATGCTCT?CTAGACAAAG?TTTTAGTGCT?TTGTTTGATA?ATTTCATCCA?CCACAGATTT 9540

GTTGGTAATT?TTAACATCAT?ACACGCCACT?AAAATCAATG?TCGTCCATTG?TGAGAATCTT 9600

AATACTATCG?CCCTCATTTT?TGTAAAAACT?TGGGGGGATA?TTCATCAGTT?GCCCTAGAAT 9660

TTGATTAGAC?ATCTGAGCTG?AACTTTGCAT?ACTACCATTG?ATCGCTTGAC?CCAAAGCGTA 9720

ATTAAATTCA?GGTATCCTTT?CACTTCTACC?TTTGCCAAGG?CCTATGAGTT?TATCTAGAGC 9780

TATGATAGGC?GCAGTTTGCA?AGAAGCTATT?AACCACGCTT?GCTATCACAG?CAAAGCCTAT 9840

GCGCTTCATG?AAGTGGTTAT?TCACATAGCC?ATCTACCCCT?GCTTCACCCA?GCATACCTGC 9900

TGCTTGAGCG?TTTGCTAGAG?GTATTATCAC?ACCATCAGGC?GTAATGGCTT?TAGTAAAGAC 9960

TATCATTAAG?CGTGTCATAA?TGGGTGTGCC?ACCTTTCACG?CTTTGATAAT?TCCCATACAC 10020

CTTAGTGCCT?TTGTCTAGTA?AGATCATAGT?GCCGTTCATG?TTCCATACAT?CTTTGGCTAC 10080

AACCCCACTC?ACTATACCTG?TGAGAGTGGC?ATCTACTTTA?GAAGTCAGAG?TGATTTCAAT 10140

AGGGGTGTAT?TGCGCTAAAA?CAAATGTGGG?ATCACTCTTG?CCTATAAAGG?CCTGTTTGAC 10200

AGGGCTTGTT?TCATCTTGTG?TTTCTGTTTT?CTTTTTGTCA?TCAATGGGAT?TACCATTTTC 10260

ATCTACAAAT?TCCCCACTCT?TTTCTTTTTT?GTTCTTAAGA?GCGATTTCAC?TGATATTCTT 10320

GGCAGTTTCT?GCGACATCTT?TGTCTATTTT?ATTGCTTTCT?ACTCTAGCTT?CTGCTGTGGA 10380

TTTTTTACTT?TTTTCTTTAT?CGTCATCTTT?TTTATTGCCA?CCTAAAGCCT?TAGCTAATTT 10440

AGCTTCTAAA?TTCTTATCCT?TAATGGTTTT?TTCTGTTTCG?TATTGCTTGG?TAATGTCAGG 10500

CTCTATGGAA?GCATAAATAG?GATTATCGCT?AGCTATTTTG?TCCGCATCAA?CATTAGTGGC 10560

GTTAATAGTG?GCAATATCGC?CGCCATTTTT?GAAATCCATT?GGCAACAATG?GATAACCTTT 10620

AGCCGCCATG?TTATCAAAGG?TTTTGCGGTT?TCTTAGATCG?CTATAAATCA?GATCCACTTC 10680

ATCAGCTTGT?CGTTTAATTC?CTAGAATTAG?CGCCCTTTCA?CTATCGCTCA?AGCCCTCTAA 10740

ACATTGCTCT?ATGGCTTCTT?GATCAGTAGG?GTCATCTAAG?TTATCCAAGC?ACTCGCTTGC 10800

TTGATGCAAT?CTTTCTGTTT?TACTCAATTG?ATTTTGTTTG?CTTTGTGTGC?TTTTATTTTG 10860

GATTTCTTGG?ATCAAATCGC?TATAAAGGTT?TTGACATTTC?CTTTTTTCTT?CATCGGTCCT 10920

AGCCGTTTTC?AAACAATCCA?AGACAGCCTT?TTCTCTAGCT?TCTTGCAGGT?ATTTGAGCTT 10980

CTCTTCATCG?CTCAAACCAT?CCAAACACTT?CATAATGGCC?GCTCTGTCGT?TAGGATCGGC 11040

GTTTTTCAAG?CAWTCTTTGA?TCGCTTTATC?YTTTTGYTGG?AGTTCTTTCG?CTAAAAATTT 11100

CCTCGCTTCA?GGGGTGAGTA?ATTTCTCGCA?TTCTTGTTTC?TCTTTTTCAT?TCCTAGCTTT 11160

TGATACGCAG?TCCAAATAAG?CCTTGACGCT?CTTCTTAACT?TCTTGCTCTA?AGAGTTTTCT 11220

CGCTTCAGGG?GTGAGTAATT?TCTCGCAAGC?TCTCCTTTCT?TCTTCATTTC?TAGCTTGAGA 11280

GAGGCAGTCT?TTATAAGCTT?TAAGACTCTC?TTTAGCTTCT?TCTAAAAGTT?TTTTCGCTTC 11340

AGGCGTGAGT?AATTTCTCGC?AAGCTCTCCT?TTCTTCTTCA?TTTCTAGCTT?GAGAGAGGCA 11400

GTCTTTATAA?GCTTTAAGAC?TCTCTTTAGC?TTCTTCTAAA?AGTTTTTTCG?CTTCAGGCGT 11460

GAGTAATTTC?TCGCATTCTT?TTTCTCTTTT?TTCATTCCTA?GCTCTTGATA?CGCAATCCAA 11520

ATAAGCCTTA?ACGCTCTCTT?TGGCTAAAAC?CTTTTTCTGC?AAGTCTTTAG?GGAGATCTTT 11580

GACACACCTC?TTTTTCTCAA?GCTTCGGTTT?TAGCACTTTT?TCAAACAATC?CTAGCGCTTN 11640

GTTGCTCCTA?AAAGCTTTTT?CGCTTCAGGG?CGTGAGCAAT?TTCTCCCATN?CTTTTTTCTC 11700

AGCTCCAGTT?TNTGNCCTGG?AGANCCGCAA?TCCTAAATAN?GCTTTAAACN?CTTCCTTTNA 11760

GCTTTCNTCT 11770

<210>118

<211>25238

<212>DNA

<213>H.pylori

<400>118

TTTTTCGCTT?GAGGCGTGAG?TAACTTCTCG?CATTCTTTTT?TCTCAGCTTC?AGTTTTGGCT 60

TGAGATACGC?AATCTAAATA?AGCTTTAACG?CTTTTTTTAG?CTTCTTCTTC?TAAAAGCTTT 120

TTCGCTTCAG?GCGTGAGTAA?CTTCTCGCAT?TCTTTTTTCT?CAGCTTCAGT?TTTGGCTTGA 180

GATACGCAGT?CTTTATAAGC?TTTAAGACTC?TCTTTAGCTA?AAATATCGCT?TTGTAAGTCT 240

TTAGGGAGAT?CTTTCAAACA?CTTTTTTCGT?TCTCCATCAG?TTTTAGCGTT?TTTCAAACAA 300

TCTAGAACCT?GTTGTTCTAA?CTTTTTTTTC?GCTTCAGGCG?TGAGTAACTT?CTCGCATTCT 360

TTTTTCTCTT?TTTCATTCCT?AGCTTTTGAT?ACGCAATCCT?TGTAAGCCTT?GACGCTCATA 420

TCAGCTAGTA?GTTCTTTTTG?CAAGTCTTGG?GGAATATTTT?TCAAGCACTC?GTTTCGTTCT 480

TCATCGGTTT?TAGCGTTTTT?CAAACAATCT?AGCGCTTGCT?GTTTCAATCT?TTCTATAGCT 540

TCTTTAGACA?AGCCTTTCAA?GCATTCGTTT?TTCTCAGCTT?CTGTTTTAGC?GTTTTTGATA 600

CAATCCTTAT?ACTCTTGAAG?CTCTTTTTGA?ATCCCTAATT?CCTTACGGAA?TTTCTCTCTA 660

ATCTCAGGGT?CATTTATGAG?TTTTAGGCAC?TCGTTTCGTT?CTTCATCGGT?TTTAGCGTTT 720

TTCAAACAAT?CTAGTGCCAC?TTGAACTTTT?TGTTGGTTCA?GTAAGCTTTT?TTTCAGGTTT 780

TCATCTTTGA?TTAAATCTAA?ACACTTGATC?CTTTCTTCTT?CAGTTTTGGC?ATTTTTGATG 840

CAGTCATTAT?AAGCCTCTAA?AGTCCTTTTC?ATTTGATCTT?GAAGTTTTTT?GTCTTTGATA 900

AGCTTCAAAC?ATTCTTCATA?GTTGCCACCA?TTACTAATAC?ATTCATAAAA?GGCTCTCAAT 960

GGGTTTTTGT?CCTCAATTTC?TGCAATATTC?AAATAGTTGT?ATAAGGTTCT?ATTGGGATCG 1020

TCATTGAAGA?AAAGATTCTT?ATCGATCATA?TTGCCTTTTT?CATTCCGTTC?TTTCAGCAAT 1080

CGGTTATACT?CTTGCCTTAT?TTGGATTTCA?TCATTGACAT?AAAGATTCCT?GTCTTTGCTA 1140

AAACGAGAGC?TTTTATCTTC?CAAAGGTATG?AAGTAGTGAA?AAATGCTTCT?AGAAAATAAA 1200

ATAATCACGA?TAAGAACAGC?GCTACAATAC?CACCAATAAT?GTATTTCTTT?TTGCTTCCTT 1260

TGATAATCTC?TTGATCGTTA?GAATCGTTAA?TTATTTCTTC?TGACTCGTAT?TCATCAAAAT 1320

TGGTTTTAGT?TTCTGTGGGG?TTGTCAAGAT?AATCTGAGCT?TTCTTTGGAT?TCTTTTGAAG 1380

AATCTTCAAA?ATGATTGGCT?TCTGTTGCTT?CTTCATTGGA?TAAATCTTGG?GGTGAATGTT 1440

GTTGGGTTTT?TTTAGAAGCT?TCATCATCAA?TTAAGTCCAT?TTGAGTTTGG?GTTTCTTCTG 1500

ACTCGTATTC?ATCAAAATTG?GTTTTAGTTT?CTGTGGGGTT?GTCAAGATGA?TGATCTGAGC 1560

TTTCTTTGGA?TTCTTTTGAA?GAATCTTCAA?AATGATTGGC?TTCTGTTGCT?TCTTCATTGG 1620

ATAAATCTTG?GGGTGAATGT?TGTTGGGTTT?TTTTAGAAGT?TTCATCATCA?ATTAAGTCCG 1680

TTTGAGTTTC?TTCTTGATAC?CCATTATTTT?CTTGATTGTC?TTCTTCGTTC?GGTTCTTGGA 1740

TTTCTTCATC?TAAATTCTTT?TGCTGAGTGA?AAGGTCTTTT?ATTATCAACT?AATTTTCTGG 1800

CTTTTTTGAA?TAACTTGTCT?GCTAGACTGC?CATTGCTAGA?TTCTGAAGTT?TCATTACCTC 1860

CAGAATCCAT?TTGAGTTTGG?GTTTCTTCTA?GCTCGTATTC?ATCAAAATTG?GTTTTAGTTT 1920

CTGTGGGGTT?GTCAAGATGA?TGATCTGAGC?TTTCTTTGGA?TTCTTTTGAA?GAATCTTCAA 1980

AGGTGATTGG?CTTCTGTTGC?TTCTTCATTG?GATAAATCTT?GGGGTGAATG?TTGTTGGGTT 2040

TTTTTAGAAG?TTTCAAATTT?ATCGTTTTCT?TCATTCATGT?CTTAACGCCT?TTTTATTTAT 2100

CTCTGACAAG?AGGGAGCTTT?TTAATCACAC?GCTCCAATTC?ACCATAGTTT?TTGATATTGT 2160

AATTTTTTGT?CAATGGATTT?TTCCCATAGC?CTTTATTTAT?TACTGTTACA?AGGGCTTTGT 2220

CTTTAATGAG?CTTAAACTTT?TCTGCAATTT?CATTAACTCT?ATACCATCTC?AATCCTGAAT 2280

TGGTCATGTT?AGGATCAATA?GCAGCATCAG?TCATGCTTAA?TTTCCCATCA?GGCTGAACCA 2340

CAAAAATAGC?AGGTTGGAGA?GTGATGTTTT?TGAAACCAAA?ATAAGTGAAT?GTGCCATCAT 2400

CAAAAATTTC?AGAGGGCATA?ATATGCTTAG?AGCGTTTTTC?AGGCGCTTGG?TAATAATTGT 2460

AGTTTCTAGG?CACAGGGTTT?CTTTTTAATG?CATTATGCAC?ATATTGAGTC?TCTAGCGCCT 2520

TTGCTTGATC?TAATATAATT?TTTTGTTTTT?CTTCTCTTAT?TTTTTCTTTG?TTGATAATCT 2580

GTTCATTGCT?CGCCATCATC?ACTCTATTGA?TATAGGCTGT?GGTATTAAGA?TTTTCTTGCT 2640

TGATCAATTC?TCTCTGCCTC?TTTGCTTCTT?CTCTCTTTTT?TAACTCCTCT?TCAATAACAC 2700

TAGAGACTTC?GTGTCTTTGT?GGGTATTCTA?ATTTGACTGT?TAGATACGCC?GAAGCAAAAT 2760

TGTCTTTTTG?AGCTATTCTC?AAAATGAATT?GATACAAGGC?TTTATTAGTC?CGCACAACAA 2820

GATTAGTTCT?CCAAGCGCTA?TCGCTAGGAG?ATAATTCTAT?GGAGTTATCC?TCAGGGCTTT 2880

TTTGAGACTT?ATCTGTCTTA?ATATTGATTT?TATCCTTGGC?TCTTTGTTTC?ACTGCCTCTT 2940

CAGCTTGTTT?TTTGTTGAGT?TCTTCAATTT?GTTTGAGCGC?ATTAGCTTGA?GCCTGTTCTT 3000

GCATGTCCTC?TAGTCGTTCC?ATTTGATCTA?ATTCATTTTC?TCGTTGTTGC?TTGATAAATT 3060

CGCTAAGATT?TTTGTTATTG?CTCAAATTTT?GTGGGTTACT?CATAGCGTTA?GTGAGATTTT 3120

CTAAATTGGC?TCTATTTTTT?TGCACGCTCT?TCCTTTCTTT?TTTCTCTTTT?ATCTTTTTGC 3180

GCTTTTTGCG?CCTGTTCTTT?AGCTTCTTTT?TCTTTTTCTA?GAGCTTTTTT?TTGTTCTTCT 3240

AATTCTTTAG?GGTCAGGCGC?ATCTACGATA?AGTTTTTTTG?TTTTTAAAAA?TTCTTGATAA 3300

TCTCTTGTCA?TTAGGGCAAA?ATTCACTGCT?TCTTTTTCAA?ACATGAGATT?ACTTTTTACC 3360

GATTTAGGTT?GAATGAATAT?ATGATTAGAA?TTAGGCACAA?TACTCCAACC?TTTATTGAAA 3420

CCTGTTGTGA?TGTAAGAAAT?AGTTTCATCT?TTTTCAAGTT?GGATCACAGT?AACATTGTCT 3480

AATGAAGTCC?AAATCGTAAT?AGGTTTTTCA?TCTCCCAAAT?AAGCAATCTT?CTTATTCACC 3540

ACTTTCACCC?TACCACGATT?AAAATTTTTA?ATGTCAGGTG?CTGCTGCTTC?TATTACGCTA 3600

GATAAAAATA?AATAACCAAG?ACAGAAACAG?CCAACAATTT?TTTTAAAAAA?TGCCTGCTCC 3660

ATCAACAATT?CCTCTTAAAA?AATATTTATA?ATTGTAACAC?AAGAATAAAG?TGGCTTATCC 3720

TTTAAACATA?GATCCACCAA?CTCTTCCCAC?CATTAAGGCA?TCTCTTTCTC?TATCCATTCT 3780

GCTACCATCC?ATAGATACAG?AGCTGAAAAT?GGTATTAACG?ATCGCATTGA?CACTCTCAAT 3840

AATCGTCTCT?ATGAAACCTT?TTAAAATAAA?TAGAGTGATC?AAACTCGCAA?TAGTTGAATC 3900

GATACCCAGT?CCCCCTTGAT?TGATGTTTTG?TATAGCAACA?GAGGGCGTTA?TGGTCAAATT 3960

GAATGCCAAT?AATGCCAAAA?CACCAAAGAG?CAAAATAGGA?ATAGCTAGAA?CCAAGATAAA 4020

CAAATTATTA?ATAAACCATA?TCAATATGTT?TTTCATAGAA?TCTTTGAACC?AATCTAGCAC 4080

GATCAAACAC?ACCGCAATAG?GGAACACAAT?ACCGCTAAAA?GCCCCCGCTA?TCAAAGGTTT 4140

CACAACAACA?GTGCTTATTC?TCATAATGAT?AGTTACTTGC?ATAAAAATAG?CGAATAAAGA 4200

AATACCTGCC?ACTTGCAAGC?CTTGTAACAA?ACTAGGAGCG?TTGTTGCCAA?CATTAGAAAA 4260

AACAGCTCTT?ACTGCAGGTA?AAATTGAATT?AACAGTGTAA?TTTAACACTA?AATCTAAAGC 4320

CCAAAAAAGA?ACCTGATTCA?GCCCAAAAGC?GCCTGCTAAA?CCAAAATAAA?TGGAATAAGA 4380

GATCTTATAA?AGATAACCAA?AACCTGCATA?GGCGATAAAA?GAGACCATCG?CCATTTTGAA 4440

TAATGTCCCC?CCAACAAATC?GCATGTATTC?AAAACCTATG?TTGATTTGAA?TGCCATTTGA 4500

AATATCCCTC?AATTTCATAA?AAGAAATAAA?AACAAAAATC?CCAAAAACAA?TATAAATCAG 4560

GTAAGAAACA?AAATCAAGAT?ATGACCCTTG?CCCTATGATA?ATATCAGGCA?GATTGACTAC 4620

ACCATATGCA?GGAAGAACAG?CAGCATCCGC?TCCTTTGACA?ACAGATTCCA?GTGCGGCAAA 4680

AGCAAGCATG?GCTGTAGCGT?TGTTTTGCAG?TTTATTTGCA?GTGAATTCTT?TACCAATCAG 4740

CCAAATTAAA?CCATCAGCTG?TAATATTCGT?AGAAGCTTGA?GCGGTTATTG?AGCTAATTAT 4800

TTGTAAAAGA?ACATTGCCTT?TCACATTGTC?CTCAACACCG?CCTTTGGTAA?AATTCTGAAT 4860

CTTGTTGCTC?AAATTGTCTA?GCATGCTATC?CATGGATACA?TCTATGTTTT?TATTTATCAA 4920

TGCATTCCAA?CCAAAATTAC?AGCCACTTGA?TGGCGTTAGA?GCAAAACCTT?GTATAGCTGT 4980

AGCAACACTT?GCCCACGCTG?ATCCCCATAA?AGGACCTAAA?GTATTCAAAT?ATTTCACTAG 5040

ATTGCTAGCG?GCTAAACTTG?TGGCTAATGG?TGTGCTAAGC?GCTTCGATCA?CACCCTGCCC 5100

TGAACTCTTT?CCACTCCCTG?ATGCACCAAT?AGATGTATAG?CCTGTCAAAA?TATCTGCAAA 5160

ACTTTTGTTG?GTTAAAACAT?AACTCGGTAT?CAGCATGCAA?TAAACTGTTT?GGTAAATTTT 5220

GAGATTTGAA?ACAATGGGCA?AATCAATAGC?TTTCAACCAA?TTAGGAACAA?TGAGAAAAAA 5280

ACTTATGATC?GTTATTAAAA?AAGTCCTTTT?AATATTAAAC?ATGCTCTTAT?TTCTTTAATG 5340

CCTTATTTTT?TGATTCCACT?TCTTTAATCT?TTCTCAAAAT?TTCGCTTACC?GTCTGTTCGT 5400

TTTGTAAATC?TGTGATTTGA?ATGTCAAACA?CTTTGAAGCC?AAAAGGATTG?ATGATAAGAT 5460

TTTCTTGAGA?AGAGTTACCT?CTAGCAAAAT?CAGTAATATA?TTCATAATTT?TCCATTGTAT 5520

CGGGTGTGAT?TTTGATGGTA?ATGAAAAATG?TTAATCTCGT?TAAGGGACTA?TTTTTGACTT 5580

TTTCTCTTTG?TATGTTAGAG?CTAATGATAG?CTTCTGCTCG?GACTTTATCT?ACAAATTGTC 5640

TGATATTTTC?ATTGAACATC?CTCATTGCTT?GGGTTTGGAA?ACTCACATCG?CAATACTGCA 5700

TTAGTTGATC?CTTGCGATCC?CTCAAAGAAT?TTTTGCTATA?ACCAAACAGC?AATGAAACAA 5760

ATTTTGAAGT?TGCACTATCC?ACAACAGCTT?CAGAATTGAC?AATTTGCCTA?GCATCGGAGC 5820

GTTTGACAAT?TTTAAATTCT?CCTGTGTATC?GATCAATGCC?ATAAACAAAT?ATATCTGTTT 5880

TCTTCAAAGG?CATCATCATC?ACAATACTTG?CTACAGCGGC?GATATTGAGT?GCCATAGAGA 5940

GATAAAAAGC?CCTTTTGAAA?GTCCTATTGG?CCTTATTGAG?TTTTGCCAAT?CTATCAAGGG 6000

CTATCACACC?CCCAACTAAA?TTTTCATCAA?TCAAGACTTC?CTCGTTTTTT?TTTCCTAACA 6060

TGCGATAGCT?TTATTGTTTA?GTTATTGGTT?TGTTGGTTGT?AAAACTTGAG?AAATTTTTTC 6120

ATTAAGAACC?CCTTAAAATA?ATCTCAATTA?TAGCAAAATT?TCTGTAAAAA?TATGTATTTA 6180

ATTTAAGGTA?AGAGTAATGA?GTAAGCAGTC?GTAACCCAGT?AATGAAATTT?TAGAAGCGCC 6240

TAATTCAAAG?AGGTAAGACA?ATCACAACTC?AGAGAGAGAA?TGGTATAATA?AGAAAACAAT 6300

TTCTCAATTT?AATTCTTGAA?AGGAGTTTCA?TGAACGATAC?AACAGAGCAT?CATGGATCCA 6360

ATCCGCTAAA?CGCCCCATCA?CCTAGCAACT?CACAGAGCAA?TGATCTTTTA?AATTTGCTAG 6420

ACTCGTTATA?TCCCAAAGGG?AGTTTAGGGG?AGCAAAGATT?TCACGAAGCT?CTAAAGAATC 6480

AAGAAGAGTT?GAAAAATATC?CTAATAGAAA?TAGAAAAGCT?ACCGCAAGAA?AAAAGGTATG 6540

AACTTCTGAT?GCAGATAGGG?CAAGCCAAAC?AGAGAATAAT?GGAAGCATAC?GCTCATTCAT 6600

TCTTGGGATA?TATAGGGGGA?CTAGAGCATC?TGTTAGGATT?ATGTATGGGT?GGGATATTTG 6660

TTCTGTTTGC?AATCTATTTT?GTATTTTTAA?GAACTAGCAA?AAATACGGAT?CTGGTGGAAA 6720

GTCTAAAAAC?AAAACTAAAA?CTTCAGTATT?TTTACTATGC?CTTTGGTGCA?GGTGCGGTTT 6780

TGTTTTTTGG?ATTAGAAACA?ATTAGATCTA?TTTATGAACT?ATATATATTA?GGAATTGGTA 6840

GCACTAACGA?CAAGGTGCTC?TTTGTTTTGA?AAAACATTTG?CTTCATAGGT?ATGGGCTATT 6900

TGATTTATAA?AGTTATTAAG?GTTATTGGTA?TAAAAAATTT?TATCAATGGT?CTTTTCATTT 6960

CAAAGAAACA?AGAATAATAA?GGAGAAACAA?CAATGAAACT?GAGAGCAAGT?GTTTTAATCG 7020

GTGCGACAAT?TCTGTGCTTA?ATTTTAAGTG?CATGCAGTAA?TTATGCGAAA?AAAGTGGTGA 7080

AACAAAAGAA?CCATGTTTAT?ACGCCTGTGT?ATAATGAACT?GATAGAGAAG?TATAGTGAGA 7140

TACCCTTAAA?TGACAAACTC?AAAGACACAC?CATTCATGGT?GCAAGTGAAG?TTGCCAAATT 7200

ACAAGGACTA?TTTGTTGGAT?AATAAACAAG?TTGTATTAAC?TTTCAAACTT?GTTCATCATT 7260

CTAAAAAGAT?TACGCTCATA?GGCGATGCCA?ATAAGATACT?TCAATACAAG?AATTACTTCC 7320

AAGCTAATGG?GAGCAAGGAT?CTGCATTGAT?TTTTACTTGC?AGCCTACTTT?GAATCAAAAG 7380

GGTGTGGTGA?TGATAGCGAG?TAACTACAAT?GATAATCCCA?ACAACAAAGA?ACAACCACAG 7440

ACCTTTGATG?TGTTGCAAGG?AAGTCAGCCA?ATGCTAGGAG?CTAACACAAA?AAACTTGCAT 7500

GGCTATGATG?TGAGTGGAGC?AAACAACAAG?CAAGTGATCA?ATGAAGTGGC?AAGAGAAAAA 7560

GCTCAGCTAG?AAAAAATCAA?TCAGTATTAC?AAAACGCTCT?TACAAGACAA?GGAACAAGAA 7620

TATACCACTA?GGAAAAATAA?CCAACGAGAA?ATTTTAGAAA?CATTAAGTAA?TCGTGCAGGT 7680

TATCAAATGA?GGCAGAATGT?GATTAGTTCT?GAGATTTTTA?AGAATGGCAA?CTTGAACATG 7740

CAAGCCAAAG?AAGAAGAAGT?TAGGGAGAAG?CTACAAGAAG?AAAGAGAGAA?TGAATACTTG 7800

CGCAATCAAA?TCAGAAGTTT?GCTCAGTGGT?AAGTGATTGG?AAGAAAGGGA?GAGAGTAGAT 7860

TTTTCTAAGG?GTAGAGAGCA?ACGCCAATAG?GCGTTAGCCT?TGCTTGATAG?GTAAGGCGAT 7920

CAAGTAGGTA?ATCTTTTTAA?AGCACTCATC?ATTTTTTAAT?TCTATCTCTG?CCTAAGACAA 7980

ATATTTTTCA?AACTGAAGTT?TGTTAGTTAC?ACCGAGATTT?TTTGTTTGTT?TTCCACATCA 8040

AGCATTTTGC?ACTCCTTTTT?CTTTCATGTA?TTTTTCAAGA?TCAAATTTCA?TTAGCAAATC 8100

CCTAACATAG?TCGTTATATT?GTTCAATGGT?TTTTAGATTA?GCATAGAAAT?TCACTTCTTC 8160

ATCTGTCATC?ACAAACAATT?TCAATAGTGG?GAGTTTAGTG?CCATACAATT?CTATTTGCGA 8220

GTCCATTTCT?CTAATACTCA?TCTTGAACAT?GATGGGCTTA?CTGAAGAAAG?GCAGAAATAT 8280

TCCAAGAATT?GATCGATCAA?ATTTAGAGAA?TAAGAAGTTA?GGATTCTTTG?CAATCGCATG 8340

CAACAGCTCC?ATAGTCTCAC?GCTCAAGCAA?TTGATAAACC?TTTTTAAATT?TATCAACACC 8400

AATGCTTTTG?ATAACAGCGC?GATAATCTTT?CATGTAATTT?CTTAGAACCT?TATCTAGTGC 8460

TCCCTTGTTT?GTATGCATCT?GTTTGAAAAA?ATCATGCATG?GTTTTTATTT?GATCTATGAT 8520

TTTCTTTTTT?TCATCAGTGT?TTAAAAGTTC?GTTCTCTTGC?AAACTCTCAA?TAAGTTTTTC 8580

TTTCTTATCT?TTTGAGTCAG?CAATCATTGA?GAAGAGTTTT?CGCATGTTAT?TACTCATATC 8640

GCTCTTGATC?CCTTCAATGG?ATTTTGTTTC?TCTTTAGATT?GTTCAAATCG?TAAAGGTTTG 8700

TATTAAAATT?ATACAATATC?TGTTGTGTGA?AAATTTCAGA?GCGGCCATAA?TTCAAAGAGC 8760

AAGAAACTAT?TTTTTAACCA?TAAAATATTG?TTTCAATCAC?TCTTATATCT?AGTTTTTCAA 8820

AACCTACAAA?AAACGCTTTC?ACAAATAGCT?CTAAAAACTG?ATTTAAAAAA?ATTTTAATGC 8880

TATAAAAAAG?CAAGATAAGT?CGTAAAAATG?CGTTACAACT?AAAATAAAGG?AATAACTCAA 8940

TTTTCAAAAA?GGAGTCTTAA?GTTACCATTA?TTACGATGTT?AAACAAGTTC?GTAATTAAAA 9000

TTCTCAAGAC?CAAATACATT?GGAAAAAAAA?CCATATCAAT?GGCATAGAGA?GTTTTTGATC 9060

CTTTTAAAAA?GGAGTGTGAG?TTTAGGTATA?AGGAAAAACT?ATGTATCAAG?CCTTGTTAAA 9120

ATGGATTAGA?AAAATCCGCT?TTAAGTTGTC?TTGACCCTTT?TTTAAACTTT?CTTTATTTTT 9180

AAAAACCCAT?AGCAATCTTA?ATACCAAACT?CCATGATTTT?AAATTTATGT?GTTGGCAATT 9240

TTGTTTTTGG?TATGGAGGTA?GTTTTCCATT?GAAAAATATT?ATTATAATCT?CTTTATTAAA 9300

TGATAGGCTT?GGTTATAGGC?AAAAGGAGTG?TTGTAATTTA?TTGGATTTCA?TAGAAGTATC 9360

TTAACACTTT?TTAGTTTAAA?ATGGTCTATT?GTTAGGAGTT?GTGGGGACGC?TTCAATGTTT 9420

AGCAGAATAC?ACTAAAAATT?AAATGGATGA?GATAGAACGA?TACTAAAAAT?AGCCTAATGG 9480

GCTAGGCACT?TACATATGGT?GCTTTAAAGG?ACGGAGTTTT?TCGCTAGTAA?GATAAAGTTA 9540

TCATTAGAGC?TTGAGATACT?TATAAGAACC?AATTTTGCCA?TTGAGTCATA?AGTATGATTA 9600

GCTTCATTGT?GAAATTTGCA?TGGCTTAAGA?GATAGTATTT?GCTTATTACG?CTGAGAGAAA 9660

CGAGTAGCAA?AAGATAAGTA?GTGTAATAAA?AAAAGCTAGG?TTTTATTATA?AGAGCAAATA 9720

AGAATAATAT?TGGATAAACT?AAAATCACCC?CTGCCCCATA?AGAAAAAAGC?CCTATTAAAA 9780

AACCTATAAC?GATAGAGCTG?ATATTGAACA?GCCTATAATA?AAGGCTGTAC?TTATCTAAAT 9840

GTTTGTTGAA?AGAATGTTTG?AATTGTAAGA?AGTTTTGTTT?TAATTTGCTA?GTCGGCTGTT 9900

TCATTTTGGT?TTTTAAAGAA?ATAGTTCAAG?GCGGTGAACC?TATAAAGAAG?CATAAAATAA 9960

TAAATATTTT?ACAAAACCAC?CCTAATCTAA?CTCCAAATCT?CAAAGAATAC?CCCACTTGCT 10020

GATACTAACA?TGTGGCATAG?CACAAACCAA?CGATTTGTTT?GTTTATGCCA?AACAAAGAAC 10080

AGAAAACATC?TGTTAAAGAA?TAAAGGAGTT?TTCCATCTAA?AAAACACAGA?TCCATTTTAT 10140

AAAAATAATC?TTAAGAGAAA?CTTAAAAAAT?ACCAACAAGC?CGCATACAAG?CAAGAAAAAC 10200

ATAACACTAT?AAGACCTAGA?TTTCACTTAC?CTTTTGGATA?TGGAAAAATT?TTGATCCATA 10260

GTTTTGTAAA?AATTGTGGTA?AAATGCATTG?ATACTTTTTG?AAATTTTAAG?GTTACAAAAA 10320

TTATAAGATG?CTTGCAAAAA?TCGTTTTTGG?CTCATTGGTT?GCGTTTGGAG?TTTTGTCGGC 10380

TAATGTGGAG?CAGTTTGGTT?CATTTTTCAA?CGAGATAAAA?AAAGAACAAG?AAGAAGTGGC 10440

TGCAAAAGAA?GACGCTCTTA?AGGCTAAAAA?GAAACTCTTA?AACAATACGC?ATGATTTCTT 10500

AGAAGACTTG?ATTTTTAGAA?AACAAAAAAT?CAAAGAGCTT?ATGGATCATA?GAGCTAAAGT 10560

TCTTTTAGAA?TTAGAAAACA?ATATACAAAA?AGAGAAAAAG?AGGCTTTAGA?GAAAGAGACA 10620

AGAGGTAAAA?TTCTCACTGC?TAAGTCAAAG?GCTTATGGTG?ATCTAGAGCA?AGCCTTAAAA 10680

GATAACCCTC?TCTATAAGAA?ACTTCTTCCT?AACCCTTATG?CCTATGTTTT?AAACCAAGAA 10740

ACATTCACCA?AAGAAGATAA?AGAGCGTTTG?AGTTATTACT?ACCCTCAAGT?GAAAACGAGC 10800

AGTATTTTTA?AAAAAACTAC?CGCTACCACT?AAAGATAAGG?CTCAGGCTTT?GCTTCAAATG 10860

GGTGTGTTTT?CTTTAGATGA?AGAACAAAAC?AAAAAAGCGA?GCCGATTAGC?TTTATCTTAT 10920

AAGCAAGCGA?TTGAAGAATA?TTCCAATAAC?ATTTCTAATT?TATTGAGCAG?AAAAGAATTG 10980

GATAATATAG?ATTATTACTT?ACAGCTTGAA?AGAAACAAGT?TTGACTCTAA?AGCAAAAGAT 11040

ATTGCTCAAA?AAGCTACTAA?CGCGCTTATT?TTTAACTCGG?AACGCTTGGC?GTTTAGCATG 11100

GCGATTGATA?AGATCAATGA?GAAATACTTA?AAGGGCTATG?AGGCTTTTTC?TAACTTGTTG 11160

AAAAATGTCA?AAGATGATGT?GGAATTGAAT?ACTCTGACTA?AAAACTTTAC?CAATCAAAAA 11220

TTGAGTTTCG?CTCAAAAACA?AAAATTGTGT?TTGTTGGTTT?TAGACAGCTT?CAATTTTGAT 11280

ACCCAATCCA?AAAAATCTAT?ATTAAAAAAG?ACTAATGAAT?ACAATATTTT?CGTAGATAGC 11340

GATCCTATGA?TGAGTGACAA?AACAACTATG?CAAAAAGAAC?ACTACAAGAT?ATTTAATTTC 11400

TTCAAAACAG?TGCTTTCTGC?ATACCGAAAC?AATGTTGCCA?AGAATAATCC?CTTTGAATAG 11460

GAAAGGAGAC?ACTCTTGAAA?AGTATCTTCA?AAAAACTAGG?TTCTGTCGCT?CTTTATTTTT 11520

TAGTTATTTA?TGGGGGCTTA?AACGCTATCA?ATACAGCATT?ATTACCGAGT?GAATACAAAA 11580

AATTAGTGGC?TTTAGGTTTT?AAAAAAATCA?AAACATTCCA?TCAAAGACAT?GACGAAAAAG 11640

AAGTTACAGA?AGAGGAAAAA?AAATTCGCCA?CTAACGCTTT?GAGAGAAAAA?TTACGAAATG 11700

ATAGGGCGAG?AGCGGAGCAA?ATTCAAAAGA?ATATTGAAGC?GTTTGAAAAA?AAGAACAACT 11760

CTTCTATTCA?AAAAAAAGCG?ACTAAACACA?AAGGACTACA?AGAATTAAAC?GAAACTAATG 11820

CTAACCCTTT?GAATGACAAC?CCTAATAGCA?ATTCTTCCAC?TGAAACCAAA?TCCAATAAAG 11880

ATGATAACTT?TGATGAGATG?ATCAATAAGG?TGAATGAAGC?TTTTGTGAAA?CCTGCTGCTC 11940

CGCTTGTGCC?TAATGAGTGG?AGAACACCTG?AAATTGAAAT?CATTATCAAT?GAGTGTATTA 12000

TTTCAAGCAA?CGATTACGAT?GGGTTAAGAA?AGTGTTTGAT?CAAAGGCATC?AAGGATCAAA 12060

AAATTCTTGC?CCCCTTATTA?GAAAAAATTC?AAGAAATAGA?GACAGAAAAT?AACAAGTTTT 12120

CTAGACAACA?CTTGAGTGGT?TTAAAACTCG?CTCTTAATAA?CAGCAACAAT?AGAACCTTTC 12180

TTATAGCTTC?ATGCGCTATT?TGTGAGAAGA?GAAAAAAAGA?AATGGAGCAA?GAAAACAACC 12240

ACCAAGATAC?TACAAATGCA?AGTGAGTTTG?GAGCTACTGA?TGCAAAAGAA?AATGAAGCAA 12300

AAGATGCAGC?ATTCTCAAAC?AATCGCTCTA?AATCTGAACT?GCCCAATAGC?GTCATTAATC 12360

AAATAGAACA?AAGCATCGCT?CATGGAAAAA?ATAGCGATCA?AAATTATTAG?CTCAAAAAAA 12420

CAACTAGAGA?AACAAATCCC?AAAGGTTAGA?AATCATAGCT?TGTTGTCTCA?GAAAAATTAT 12480

TTAACAATGA?TCTTGCTTGA?TTGCCTTTCT?TGTAGGTATT?GCCGCTTGCT?TTGTTCTAGG 12540

GATATTTCTA?ATGCGTCCAA?CTTCTCTAAA?TAATTTAAAA?AGACCTTGTC?GTGAGCTAAC 12600

ATGAGCTTTC?TGATTCCTTT?AATGAAATTT?TTATTCTTTG?GGCTTTCTCA?CAAGCGTTCG 12660

GAAGCAGGAT?TAAGGAAGTT?GTACCTCCAA?TGTTGCTCTG?ATACGCCTTT?AGGAGAAGTT 12720

TCTAAACGCT?CTCTTATATT?TGTTTTTCTG?GCTCGATTTT?CAGCTTCCCT?TCACAATAAA 12780

AACTAAAACT?TTATCGGTTA?TTCCGCATTG?CTGCTCAGCA?GTATTTTGGT?CTAAGGGATT 12840

GATTTTCATA?TAGGTTAATA?AAAGTTCAGG?GCTAGACATA?TAAGTCTTGA?AAATCACATC 12900

TTCTGAGATG?AAAAATAACT?CATTCGCTTC?AAAATTGGCT?TTCAATAACG?CTAAATCTCC 12960

CCTCAAAGCA?ATGGCCGCTT?TTTTGATGTT?TAGAGCATCT?TCTTTACCTA?TTTTATCATT 13020

AGCGCTAGGG?CTAGTGGTTG?AAAAAATCTC?ATCTAAGTTT?TTGAGCACTT?GCTGGTTGGT 13080

CTCTTTGTAG?GTGCTATCAA?GTTGCTTTAA?ACCGCTTGTT?ATATCTTCTG?CCATCAAAAC 13140

AGACAATAGC?AAAAAAGAAG?ATATGGTATT?TTTCACGAGT?GTTTTCATTT?GACAATAACT 13200

TTAGAGCTAG?CAATGTTTCT?TGCTGTCGTT?TCTCTCTCTA?ATTTCAGTTG?TTCTTCCCAA 13260

AGATCGGCTT?TTTTTTCAAG?ATTCTCTATA?TAGTTTAAAT?GATTTTCTGC?GTTTAAGATA 13320

GCAACTTCTA?TGAGCGCATT?CAAATCTACT?GATCCTTTTA?AGGTTTTGAT?TTCTTCATTG 13380

ATCCCATTCA?AATAAGCGAT?ATTTTGAAAA?TCTGCATCAT?TTAGTTTATT?TTGAATAAGG 13440

GCTACAATCT?TTCTGTAATT?CTGAATAACC?TGTTCCATAA?GGCATGCTGA?AATTTTTAGC 13500

CCATCAAGAT?AGGGGCATTT?TGTGGGCGCT?AGAGTAAATG?TTTCAATGAT?TCCAAATGGT 13560

GCGCCCATGC?TTGAAAAAAA?ACTAAGAGCA?GGCTCGTAGA?TGGTGCTTTG?AAACAAAGCC 13620

TGGCCTGTTA?GGGAATTGTA?GTCAATAAGG?GTCGCTTTTT?GCATAGCCAC?TTTCAACCAT 13680

GTTTCAAAAC?CTTCTAATGT?TTCTTCAAAC?GCCTTGATAC?CAATCGTATT?GTAAGCGATG 13740

TATTTAGCGT?TGTCAGAAGA?ACTTCCTAGA?GCTTGAGAAA?GCATTTCCAT?TTGTGTTTTT 13800

AGGGTAACGC?TCGGTTCAAA?GCTGTTTTTT?AACGCTTCTA?AGAGAGCGTT?TTGCTGGTTC 13860

ATTTTGAGCT?TGATTATTTC?GTTATTTTTT?TGGAGTGCGA?TTTGCATGTT?TTGGATTTCT 13920

GTTTGGGTAT?TAATTTTTTG?TTTTTCCACG?ATCATGTTGA?CATTTCCTCC?CAATGCACTA 13980

AGCGCGCTTG?AATACCCTTC?CATGATGCCA?AGCAAGATGT?CTGAACCTGC?AAAAAACCCC 14040

CCTGTCATGC?TATTGACACC?ATTAATAACG?CCATTAGCCC?CTTTTAACAT?AGCGCTTATA 14100

GTTGCAAGCT?GAGTTCTCAA?TTGTCCCTCT?ATTTGCGCTT?GAATGGCTTT?TTCTTTGGCA 14160

CTAGATTGAG?CCTCTATGGC?TTTTAATTCG?GCTTGAGCGG?TTTTTTGTTT?GGCTTGTGCA 14220

TCCGCCTGAA?TGGCTTTTAA?GGCAGATTCA?AGCGTTATTA?CTGCCCCTGC?ACCATTCAGA 14280

AACAAACCAC?AAAAAGTTAA?GAAAGAAAAT?ATGCTTAAAA?AATATTTCAC?ATCTCTTTCC 14340

TCACTTCACG?ATTATTTTAG?TTTGCACCCT?TTCTGTTAAG?TAGCTATCTT?TTTGCCCCTT 14400

AAGTTTGTCT?TTGATGTAAT?CAAGATAAGT?CAAATGCGAT?TTCAAAAAAG?ATTTATTCGC 14460

TACTATATTG?TAATTATATA?GCGAGCTTAT?GTTAGAAATC?GCTTGAGTAT?CATAGGTGCT 14520

AGTAGCTAAT?CCTGATTGAT?TAAGTATCAT?TTGAGAAGCG?TTTTGCAACA?AATTGGTATT 14580

GTTTTTCACA?AATTCTATAT?AGTATTCTCT?CAAAATTTCT?GCTACTTTTT?CAGCATAGCA 14640

ATAAACGACA?AGAACTTTGT?CCCCAGTAGG?GCATGCAGGA?GTGGTCATAG?GATTAACGCC 14700

TGAAGTTAGG?GCATTAGCGG?CTAACGCTTG?GTATTTGGCA?TAAACAGTGG?GCATAGAGAC 14760

ACTCATAGGA?GTCATAGAAA?TTTGCATGCA?ACTAAAAAAC?ACTTTTGATG?AGCTAGCAAG 14820

CGCACCTAAA?GCGGTACAGC?TATCAAGGGA?ATCGGCTGTA?TCATTCATTG?AGCTGTTGCT 14880

TGCTTGAGAA?CGCAGTTGCT?CTTGTAGGGC?TAGGGTGTAT?TTTGGTGCTG?CACTTGTAAT 14940

ATTGCCTAAG?ATACCGCTCA?TCATTTCAAC?CGTTGTTGGC?ACACTAGGAA?CAGCGATTTG 15000

ATTCGTCGCA?TAAGCTTCAA?TAGCGCTAGG?ATTTTTAGGG?GTAGTGTTAC?TCGCTAAAAT 15060

GCTTGCAATC?TGACTATTAA?CAGCACCAAT?TTGCGCGCCT?TGCGTGTTGC?CTTGCGCGTT 15120

AAATTCCCCT?GTTAATTTGC?TGATATTTAA?GATATTGTTC?CCCACAGCCA?TGCTTTGATC 15180

GTTAAAACCT?TGATACAATT?GGTTGTATTG?TTGGTTAGCG?GCTTTCATAG?GCATGCTTAC 15240

GGCTTCAGCG?ATGCTTTGAT?TGTATTGGGT?CATGATAGCG?GTCATTTGTG?GATTCGTAAA 15300

TCCCACAACA?ATAGGAATAA?TCGCTGCTGA?CATAGCACCC?GCTACTATTC?CTGCAAATGG 15360

CCCCGCAACA?CCACTTGTGC?TTGAGATGAT?TGAGGAAATT?TCCGATAAGA?AGCCTGCAGA 15420

AGATGATTCA?TATATAGCTT?GCGTGCCTGC?CATGTTAAAA?CCCCCCTAAG?CTTGGTGGTA 15480

AAAACGATGA?ATCTGGATAT?GTTGGTGCAT?AACCATACAT?GAAAGGATTG?TTTGGGCCGT 15540

AATCGCCCAT?CATTTGGCTC?ATGAGAAGAT?TTTGAATGCC?CCACATCGCA?TTGATACCTA 15600

GATTATCATT?AGGTTGAAAA?CTCCCTAAAC?TTATGTTATC?AAACTTGATA?TTAACATTCT 15660

TATCATTATA?GTCATTGAGT?ATGGCCACTT?TTTGCTCTAG?GGTTTCTTTA?GGGATCTCTA 15720

TTTTTAGCTG?ATCTCTAGAA?ACAAGCCCCA?CGCTATTTAG?TGCCATATCT?TCAGGACTAA 15780

TATCTTTTAT?ATCAGTGTTT?TGGTCAGCGT?TAAGCGGAGC?GTTAAACATG?CCAATGATAA 15840

GACACCAAGC?AAATAATAAT?TTAATTTTAT?AAAAATTCGT?TTTCATACTT?TTGACTCCTT 15900

TATTCTTATT?TTTAGCACTA?TTCTAGCGCA?TTAACACCAC?TCAATCGCTA?TTTTTGTTTT 15960

GATTTTTTTG?ATCGAGCATT?TTGTTTGTTA?CTTCATCAAT?GTTTTGAAAA?TATTTTTCAA 16020

AAAGCTCTTT?CTTTTTAGCT?TCAACGCTCA?TATCAACCCT?GAATCCAATT?AGGAACAATG 16080

GAGTCCATGA?TTAAATGCGT?GAAGTCATAG?GCATGATTTG?TTGGGTATAT?TTTGTTTTGA 16140

ACATAGTATT?CTAAAAAATT?CGCTTGAACA?AAAAAATTCT?CTATATCGCT?CTGCATATCC 16200

TCGCTTATGT?TGTTATTGAT?AGGTTTTTCT?AGTAATCTGA?GAATCCTATA?CGACTGCATG 16260

ATAGTTTCCA?GCATGAAGTA?AACATAAACA?TAAACTAATG?AGACAAAAGA?ATTATTTGCT 16320

TTAAACGAGC?TTGCATCATT?TTTCCCACTT?TGAAGAGGAA?TTAATCTTGA?TAATGTTTTT 16380

TGGGGATCTT?GCCCATCGTT?TATTTCTTTA?AAAAAGCGGA?AGTCTAAATC?CTGATTATTG 16440

AGAAATGACT?TGACAAAGTG?AAGATTAGCA?TTGAGACTAT?CTATGAGACC?TGAATAAAGG 16500

TGTTCTGTTT?TGACATCATC?TATATTTAAA?ACATTCTCAT?AAAACACATT?GACATGGTCT 16560

TCTAAGAAAT?TAGAAAAATC?ATAAAGAGTG?GTAAGGTTTT?GTTCAGTGAT?TTCGCCTTCC 16620

ATTTCTTCTT?CTATGAAGTC?CAATTCTTCT?CTCAGTTCAA?AAAGATAATT?AGAAAAACTA 16680

TCCAAAATCG?TCAAGACATC?ATTTTCTAAA?ATTTTCAATA?ATTTTTGTTC?ACGCAAACTT 16740

TGTTTCATTT?TAATACTCCT?TTATTTGTTG?ATACATTTGC?CTCAAGGCCT?GATATTTATC 16800

TATGATACTA?TGGTTTTGGA?TAATCTTGTC?AATCTCTTTG?ACAAATACGG?TATCTGTGGA 16860

TAAAATTTTC?AAATATTCTT?TAGGAATGCC?TCTCAAATTA?AAACTAGCGA?TAACGCTAGG 16920

GCTTCCATCT?TGTTTGTAGA?GAATTTTCCT?ATCTAGCCCC?TTAGTGAGAT?TTCAAATTCT 16980

TTTCTGTAAC?ATTAGCCAAT?CTTTGGTAAT?CCAGAAAGAT?TTCCCCCCAT?CGTTTCTTAA 17040

AAAAATCTTT?GTAGGGCATT?GTTCTCTAAT?AGTATCAGCA?ATAGGGCAAG?CCAAAAGATC 17100

AGTGATGCTT?TGAGTCGCAA?GTCTAACAAT?AGCGTTTCTT?TTCCTTGCAG?TTTTTAGCAT 17160

GTCTCTTACA?AAATAAGCGA?CCTTTGGATC?GCCTAAATAT?TTCCAAGCTT?CATCAATATC 17220

TAAAACAAAT?CTACGCCCAT?CCATTGCCTC?TTGAATACGA?GCGAAAAGGT?AAAAACAAAT 17280

AAAGGGCGAA?ACATCATTAT?TGTCTAGGAA?ACTTGACCCA?TCAACGCCAA?TAATCGTTTT 17340

TGAAAAATCT?AAGCGATCTG?TTGCTTTATT?ATCAAAAAGC?CATTGAAATT?CACCATTGGT 17400

TGATTTGCAA?AAAGGCGCTA?ATCGCGCGAC?AAGCCCATTA?GGATCATTGT?GGTCTTTTCC 17460

GAAAGCATTA?ATAAGTTGAG?TGATGGGATA?ATCTAGGTTC?ATATTTCCTG?TGATAAGGTT 17520

GGTTACTGCC?GCTGCAAGCG?TATTAGAATC?AGCTAGGCTA?AAAGAGATGC?TGTTGCCATT 17580

TTCATCTTTT?TCATCGCTTT?TGGTGACTAG?GTTTTTCACA?AGCTCTTTGA?CAACAGAAAT 17640

AGCTGTTTGT?TTTTGCTCCA?TTGTTGCATT?GGATTTTTGC?ACACAAGCCG?CCCAAGCAAA 17700

AGGATTTAAT?CCTGTATCTG?TCCCTAGCTC?AATCTTGACA?TACTCCCCAC?CCATTGCGAC 17760

AATATTCCCA?TAAGCGCCAT?AATCTTTATC?CATATAGACC?ATAGTGAGCT?TTTGCTTGTC 17820

TTTACTGACA?TTAGCAGGAA?AATTGTGAGC?AAATTGTCCC?ATAGCGTTTA?GAGTCATTGA 17880

CATAAACACT?GTCTTACCTG?AACCGGTTGA?GCCAAGTATC?AAAGTGTGTC?CTGCTGAAGC 17940

TGAACCAAAA?TCAGTAGGCA?TGTGGAAGTT?CAGATAAAAA?GGCGAATTGA?TCTCGCTTTT 18000

TAGCGTCATG?ACGCTATTAC?CCCAAGCGTT?ATTCTCTTGA?TTGCCATCAA?AACTCATCGC 18060

TCTCATAGCG?ATGAAATCAG?CAAAATTATT?AGAAGTTACA?TCAAAAATAA?AAGGAAGCGT 18120

GATAAAAGAG?CAATGTTTGG?CAAAAAAGTA?ACTTTCCATA?GAGAAAGTGA?GTGCGTAGGC 18180

TAAAAAACCT?TTCAGCGTTA?AGAACTAGAG?ACGCATTCCT?TAACGCTTTG?TTTCATTTTT 18240

TCAAAGCTAT?CAGCAAACAG?CACTAAAGAA?TTACCATAAC?TGCCTAGCGT?AATATCACCA 18300

TTACCCACTA?ATTCGCTCAA?GCAACCTAAA?GTCATGCCCT?GCTCTTTAGA?ACCCCCACTA 18360

ATAATAATCC?TTCTAGAGGT?GAAAGCTAGT?TTGTCCTTTA?AAACCTGTGA?GTTTTTAGGC 18420

GAATAAGCAT?GCATAAAGAT?AAATTCGCTG?TCTAGAGCGT?TGATCTTGTC?AAACAAATCG 18480

CTCTGTGATT?TAGGGGCGTA?TTCACTAATC?TCAATAGCGC?TAAAATATTT?TTCACTCAAA 18540

TCGTCATTTA?AGATTTTTCC?ATGTTTATTG?GCAAAATAAA?CTTCTTTCAC?CCCACCATGC 18600

ATTTTTTCCT?TGAGATACAA?GTCTTTTCTG?TTGCAAATAA?AAGGGGCTTC?ATTCATTCCC 18660

ACAAGAAAAT?TGTAAAACTC?GCATTGTTTG?GAATAAACAA?CGCCATCTTT?AATGTATTCT 18720

TTTAATCTAG?TGGGGTGGTA?TTTACTCAAT?AGCTCTTCTA?TGAGCTCTAT?CCTATCCTTG 18780

AAGTTTTCAA?GCTTGGCTCT?AATAATCCTT?TGAAACTCTT?CAAAATTATT?GTCTGCAAAA 18840

TGCTTTTTAT?TCATAACGGG?TTCATTGAGA?GTGTCTAATA?AATCTTGCTC?TATGGTCAGA 18900

AAAAAACTAA?TATCATAAAA?ACTTTCTCTT?TTTTGCTTCT?CATTATAGGC?TCGCATAAAA 18960

TCATTAGAAA?AAATAAGACT?ATAGTCCCTA?TTGGTTTCAT?CAATAACGAT?TTTCTTTTTA 19020

ACGGTGTGGA?AATAAAATTT?GAATTCAGGG?GTAACAAAAT?TCCTAAAAAC?GCTATAAATA 19080

GAAGCGTGTA?ACTCTATGAG?ATCTTTTTTG?GAAGTGGTTA?AAAAATCAAT?GCCCCCCAAT 19140

TTGATTGTGC?CTAAAAGAGA?ATAGTTGTTA?GTGAGGATCA?CCCCATCATC?TAAAAAACAT 19200

TCATAGTTAT?TCGCTAGATA?GGAGTTTGCA?GCGCTCACAA?GTCTGTCTTC?TCTGTTTGGA 19260

TTTAAGTGGA?TGTCATTAGC?CATTTCTTTA?CTAGGCTTCA?TGGAAAAAAT?GCTCATGAAC 19320

GCTTTGTTTT?TCACGCCCTT?AAACAAAAAA?GGTTTTTTAA?ATTTCATCGC?TCGCTCCATT 19380

CTTTGATAAA?GCCTATAGTC?TTTCTTGAAT?CCAAGAGCTA?CAAGCACAAT?AACAATCGCT 19440

ACAATCAAAA?CAGGTTCATA?GGCTTGAAAA?AGAATAACAG?ATAATACAAT?GGTTACAAAC 19500

AATATAAATA?TAGAAGAATA?AATAAAAGTT?TCAGGGAAAC?CAAACAACCT?ATTCCCCCCA 19560

TCAAACAAGA?CTTTAAAAAA?GGGATTGACA?CCTTTTTGCA?TGTCTGCTTT?AAGCTCTTCT 19620

ATTTTTTGAA?ACTGCCGCTT?TTGAACCTCT?TGCTCTATGA?TTAGCTTTTT?TTGTTCGTCA 19680

GCTTGCTTGC?TTGCCACAAA?CACCTCTCTC?TTTATAGATA?TACCGCTTCA?CATGTAATCG 19740

TATAAAAGAT?TTTTTTGAGA?GACTCTATAG?CGCTAATATG?TTTCAAAAGA?TCATTAGGGT 19800

CATAAGAATT?GAATACGGCC?AATAAAACAT?TGTATAGCTT?ATCATCGCAT?AGAATTTCTC 19860

TTGTTTCTCC?GTGCAATGAT?AGGAAGCAGC?GTTGTTTGTT?GGTCGTGCTG?ATGCTTTTGA 19920

AAGTAAAAAA?GTCTTTCACT?TCAGGATTGA?TCTGCAATTC?CACATTCAAT?CCCATTTCTT 19980

TACCCTTTTC?ATCAAAGATT?TTTTCAATAA?TTGGATCGTA?ATGCTTCAAA?TCCTTTATTT 20040

TTTTAAGGAC?TCTATTGACA?ATCACGAAGT?CAAAAACTTC?ATCTTTGATA?ATGTCGGGAT 20100

TGACTTCTTT?GAAAGTTACT?TTCTTGTCTT?TCAAATTTTT?GATAGTCGCT?TTAAAACTAT 20160

CAAAATCTAA?ATTCGTATAA?ACACGCCCAC?TAGGAGTGTT?TTTTTCTTTT?TCTAGTGCTT 20220

CTTTTTTGGC?TTGATTATCA?TCATTTGCCA?ACCCATACGA?ACTGAAAACA?ACGAGACTTA 20280

AGAGAACTTT?CAAAAAAAAG?TCTCTTAGTT?TTTTATTACT?ATTATTGTTG?ATCAATTTAG 20340

CTAGCTCCTC?CACCTTCGCC?AATATTGAAG?CCAAACTTAG?TGCTCAAATA?GATAATACCG 20400

CCTGCCACCG?CTAACATAGC?TATGGGTTGC?GCGTAAGCAA?AAACAGTCGC?CTGACCTCTT 20460

TTGATGTCAT?CAGAGATTTT?CCAAATATCT?GCTATGCCTT?TGACCCCTAG?AGCGCAACCA 20520

CCTACGATCG?CTAGAACAGA?AATGATCTGA?ACAACCAAAG?TTCTAGTCTC?AGTAACGCCT 20580

GTTGCAGGAC?TGTTGAACGC?CATTAAAGGA?TTGGTTGTTA?TCACTAGCCC?TAAAGTTACT 20640

ACAACTTTCT?TGTAGCTTGT?CAGTGATTCT?TGTAAGAAAT?TTCATGCGTT?TCCTTTCAAA 20700

TTGAAATCAA?TCGCTTAAGT?ATATCAAAAA?AAAGTATTTT?TATGCTATTC?ATACAAGCAC 20760

TACTTTATTT?AAATCAAAAC?CGACACTTTT?GTTTGACAAT?TGGCACAATT?TAGAACAATA 20820

AACCTACTTG?TCCCAACCTT?TTTTCTTTCT?CAAGTCATTG?TAGAATTGCA?GATCTTTAGG 20880

ATCTTTGATA?TATTTTTTAA?TCGTCTCAGG?TTGAAACCTA?AAAACAAGCA?AAAACAAACC 20940

CAAGCTGATC?AGAGTGAGAA?TAAAGCTCCA?TTTTAAGCAA?CTCCATAGAC?CACTAAAGAA 21000

ACTTTTTTTG?AAGCTGTCTT?TGAAAATCTG?TCCTATTGAT?TTGTTTTCCA?TGTGAATCAC 21060

AAACACTTCT?TGTTAAAATT?TGTCTATTTT?AGCAAGTTTT?TGTCAATTGC?GGATAAAAAT 21120

GTGAATCGTT?CCTAGCTTTT?AGATGCTTGC?AACGACTGGA?ATTTTTCAAT?ATTAACAAGA 21180

TTAATGAAAA?AATGCCTAAT?ATTGTAGTAT?AATGAGAGCG?TTCAAAGACA?TGAATTGACT 21240

ATTCAAAGCG?TGTATAGTTT?TTAGCAGTCT?TTGATACCAA?ATTTAGGTAT?AGTAAGGAGA 21300

AACAATGACT?AACGAAACCA?TTGATCAAAC?AATAACACCA?GATCAAACAC?CAAATCAAAC 21360

GGATTTTGTT?CCGCAACGAT?TTATCAATAA?TCTTCAAGTA?GCTTTCCTTA?AAGTTGATAA 21420

CGCTGTCGCT?TCATTTGATC?CCGATCAAAA?ACCAATCGTT?GATAAGAATG?ATAGGGATAA 21480

CAGGCAAGCT?TTTGAGAAAA?TCTCGCAACT?AAGGGAAGAA?TACGCCAATA?AAGCGATCAA 21540

AAATCCCACC?AAAAAGAATC?AGTATTTTTC?AGACTTTATC?AATAAGAGCA?ATGATTTAAT 21600

CAACAAAGAC?AATCTCATTG?CTGTAGATTC?TTCCGTAGAG?AGCTTTAAGA?AATTTGGGGA 21660

TCAGCGTTAC?CAAATTTTTA?TGAGTTGGGT?GTCCCTTCAA?AAAGATCCGT?CTAAAATCAA 21720

CACCCCAACA?AATCCGAGAT?TTTATGGAAA?ATATCATACA?ACCCCCTATC?TCTGATGATA 21780

AGGAAAAAGC?GGAGTTTTTG?AGGTCTGCCA?AACAATCTTT?TGCAGGAATT?ATCATAGGGA 21840

ACCAAATCCG?ATCGGATGAA?AAATTCATGG?GCGTGTTTGA?TGAATCTTTG?AAAGAAAGGC 21900

AAGAAGCAGA?AAAAAATGGA?GGGTCTACTG?GAGAGCCTAC?TGGTGGGGAT?TGGCTTGATA 21960

TTTTTTTATC?ATTTGTGTTT?AACAAAAAAC?AATCTTCCGA?TCTCAAAGAA?ACGCTCCATC 22020

AAGAGCCAAG?GCCTGATTTT?GAACAAAATA?TAGCCACTAC?CCCCCACCGA?CATACAAGGC 22080

TTACCGCCTG?AAGCTAGAGA?TTTGCTTGAT?GAAAGGGGTA?ATTTTTTTAA?ATTCACTCTT 22140

GGTGATGTGG?AGATGTTGGA?TGTTGAGGGA?GTCGCTGCAT?AAGGCATCCC?AATTACAAGT 22200

TCAATCAATT?ATTGATCCAC?AATAACGCTG?CTATCTTCTG?TGCTAATGGG?GGGTCATAGT 22260

AACATAGAAC?CTGAAAAAGT?TTCATTATTG?TATGGGGATA?ATGGTGGTCC?TGAAGCTAGG 22320

CATGATTGGA?ACGCCACCGT?TGGTTATAAA?GACCAACAAG?GCAACAATGT?GGCCACACTC 22380

ATTAATGCGC?ATCTTAATAA?CGGCAGTGGG?TTAATCATAG?CGGGTAATGA?GGATGGGATT 22440

AAAAATCCTA?GCTTCTATCT?CTATAAAGAA?GATCAACTCA?CAGGTTTGAA?ACAAGCGTTG 22500

AGTCAAGAAG?AGATCCAAAA?CAAAGTGGAT?TTCATGGAAT?TTCTTGCAAA?AAACAATGCT 22560

AAACTAGATA?ACTTGAGCGA?GAAAGAGAAA?GAAAAATTCC?AAACTGAGAT?TGAATATTTC 22620

CAAAAAGACC?GTAAGGCTTA?TTTGGACGCC?CTAGGGAATG?ATCACATTGC?TTTTGTTTCT 22680

AAAAAAGACA?ACAAGCATTT?AGCTTTGGTT?ACTGAGTTTG?GTAATGGAGA?ATTGAGCTAT 22740

ACTCTCAAAG?ATTATGGGAA?AAAACAAGAT?AAAGCTTTAG?ATGGGGAGAC?AAAAACCACT 22800

CTTCAAGGTA?GCCTAAAATA?TGATGGCGTG?ATGTTTGTTG?ATTATTCTAA?TTTCAAATAC 22860

ACCAACGCCT?CCAAGAGTCC?TGATAAGGGT?GTGGGTGCTA?CGAATGGCGT?TTCCCATTTG 22920

GAAGCAAATT?TTAGCAAGGT?AGCTGTCTTT?AATTTGCCTA?ATTTAAATAA?TCTCGCTATC 22980

ACTAATTATA?TAAGGCGAGA?TTTAGAAGAT?AAATTGTGGG?CTAAAGGATT?GTCCCCACAA 23040

GAAGCTAATA?AGCTCATCAA?AGACTTTTTG?AACAGCAACA?AGGAATTGGT?TGGAAAAGTT 23100

TCAAACTTCA?ATAAAGCTGT?AGCTGAAGCT?AAAAACATAG?GCAATTATGA?TGAAGTGAAA 23160

AAAGCTCAGA?AAGATCTTGA?AAAATCTCTA?AGGAAACGTA?GAGCATTTAG?AGAAAGAAGT 23220

AGCGAAAAAA?TTGGAGAGCA?GAAACGACAA?CAAAAATAGA?ATGGAAGCAA?AAGCTCAAGC 23280

TAACAGCCAA?AAAGATAAGA?TTTTTGCGTT?GATCAATAAA?GAGGCTAGTA?AGGAAGCAAG 23340

AGCGGCCGCT?TTCGATCCGA?ATCTTAAAGG?CGTCAGGAGC?GAATTGTTTG?ATAAACTTGA 23400

AAATATCAAC?AAGAATTTGA?AAGACTTTGG?CAAATCTTTT?GATGAACTCA?AAAATGGCAA 23460

AAATAATGAT?TTCAGCAAGG?TAGAAGAAGC?GCTAAAAGCC?CTTAAAGACT?CGGTGAAAGA 23520

TTTAGGCATC?AATCCAGAAT?GGATTTCAAA?AATTGAAAAC?CTTAATGCAG?CTTTGAATGA 23580

TTTCAAAAAT?GGTAAAAATA?AGGATTTCAG?CAAGGTAACA?CAAGCAAAAA?GCGACCTTGA 23640

AAATTCCATT?AAGGATGTGA?TCATCAATCA?AAAGATAACG?GATAAAGTTG?ACAATCTCAA 23700

TCAGGCTGTA?TCAGAGACTA?AATTAACAGG?CGATTTCAGT?AAGGTAGAGC?AAGCCCTAGC 23760

CGAACTCAAA?AACTTGTCAT?TGGATCTTGG?AAAAAATTCT?GATCTACAAT?CCGTTAAAAA 23820

TGGTGTAAAT?GGAGCCCTAG?TCGGTAATGG?GTTGTCTAAA?ACAGAAGCCA?CAACGCTCAC 23880

CAAAAATTTT?TCGGATATCA?GGAAAGAATT?GAACGAGAAA?TTATTTGGAA?ATTCCAATAA 23940

CAATAATAAT?GGACTCAAAA?ACAACGAAGA?GCCCATTTAC?GCTAAAGTCA?ATAAAAAGAA 24000

AGCAGGACAA?ACAGCTAGCC?CTGAAGAGCC?CATTTACGCT?CAAGTTGCTA?AAAAGGTGAG 24060

TGCAAAAATT?GACCAACTCA?ACGAAGCTAC?ATCAGCAATA?AATAGAAAAA?TTGACCGGAT 24120

TAACAAAATT?GCATCAGCAG?GTAAAGGAGT?GGGCGGTTTC?AGTGGAGCAG?GGCAATCAGC 24180

TAGCCCTGAA?CCCATTTATG?CTACAATTGA?TTTTGATGAG?GCAAATCAAG?CAGGCTTCCC 24240

TTTGAGAAGA?AGTGCTGCAG?TTAATGATCT?CAGTAAAGTA?GGGCTTTCAA?GGGAACAAGA 24300

ATTGACTCGT?AGAATTGGCG?ATCTCAATCA?GGCGGTATCA?GAAGCTAAAA?CAGGTCATTT 24360

TGACAAACTA?GAACAAAAGA?TAGATGAACT?CAAAGATTCT?ACGAAAAAGA?ATGCTTTGAA 24420

GCTGTGGGTT?GAAAGCGCGA?AACAAGTGCC?TACTGGTTTG?TCAGCGAAAT?TGGACAATTA 24480

CGCTACTAAC?AGCCACACAC?GCATTAATAG?CAATGTCCAA?AGTGGAACAA?TCAATGAAAA 24540

AGAGACCGGT?ATACTAACGC?AAAAAAACCC?TGAGTGGCTC?AAGCTTGTGA?ATGATAAGAT 24600

AGTTGCACAT?AATGTGGGAA?GCGCTCATTT?GTCAGAGTAT?GATAAAATTG?GATTCAACCA 24660

AAAGAATATG?AAAGATTATT?CTGATTCGTT?CAAGTTTTCC?ACCAAGTTGA?ACAATGCCGT 24720

AAAAGACATT?AAGTCTAGCT?TTGTGCAATT?TTTAACCAAT?ACATTTTCTA?CAGGATCTTA 24780

CAGCTTGATG?AAAGCAAATG?TGGAACATGG?AGTCAAAAAT?ACTACAAAAA?GTGGTTTCCA 24840

AAAATCTTAA?AGGATCGAGA?AATACTAAAA?ACACCCCTTG?TTAAAACAAG?GGGCTTCCTA 24900

ACTAAAATAT?CCTAATAAAC?ACTAACACGA?AAGGCTTTGT?TCTTTATGGT?CTGTAAGGAC 24960

ATTTCCTATC?CTAAAAAGAC?TTAACCCTTT?ATTCAAGATA?TTGTTCGCAG?CGTTAATATC 25020

TCTGTGTTCT?TTATACCCAC?AATCAGGACA?CAAATATTGC?CTGTGATTGA?ATTTGAGCTT 25080

GGGGTTGATA?CTCCCACAAT?GATAGCAAGT?TTTGCTAGTG?TATTGTGGGG?GAACTTTCAC 25140

TAACAATTTG?CTATTATGCT?GTTGTTTGCA?GTCTAGCAAA?CTTGTAGATG?GGTAATTCTT 25200

TTCCAAATAT?AAAAACGCTT?TTCTGGATCT?CTAAAAGC

25238

<210>119

<211>11647

<212>DNA

<213>H.pylori

<400>119

CTCATATCTT?GGCTGTGAGT?AAGATTGACA?CCGCCACGCA?TAAGCAGGTT?TTGCAAAAAT 60

TACAAGAGTA?TCAACAATAC?GCTTCGCAAT?TTTTAGCTCT?AGTGCCTTTG?AGCGCGAAAA 120

AATCTCAAAA?TTTAAACGCG?CTTTTAGAAT?GCATCAGCAA?GCATTTAAGC?CCTAGTGCAT 180

GGCTTTTTGA?AAAGGATTTG?ATGAGCGATG?AAAAAATGCG?CGATATTTAT?AAGGAAATCA 240

TTAGGGAGAG?TTTGTTTGAT?TTTTTGAGCG?ATGAAATCCC?TTATGAAAGC?GATGTGATGA 300

TTGATAAATT?TATAGAAGAA?GAACGCATAG?ACAAGGTGTA?TGCGCGTATT?ATCGTAGAAA 360

AAGAAAGCCA?AAAAAAAATC?GTGATAGGCA?AAAACGGGGT?GAATATCAAA?CGCATCGGGA 420

CTAACGCGCG?ATTGAAAATG?CAAGAAGTGG?GCGAAAAAAA?GGTTTTTTTA?AACCTGCAAG 480

TGATCGCTCA?AAAATTATGG?AGCAAGGAAG?AAAAGAGCTT?GCAAAAATTG?GGTTATATCC 540

ATAAAAGGGG?TATGGATTGA?AAAAAATATT?ACCGGCTTTA?TTAATGGGGT?TTGTGGGCTT 600

GAATGCTGAT?GAGCGTTTGT?TGGAAATTGT?GCGCCTTTAT?CAAAAGCAAG?GCTTGGAAGT 660

GGTGGGTCAA?AAGCTGGATT?CTTATTTAGC?GGATAAATCT?TTTTGGGCAG?AAGAGCTTCA 720

AAACGAGGAC?ACGGATTTTG?GCTATTATCA?AAACAAGCAG?TTTTTATTTG?TGGCGGATAA 780

ATCCAAGCCT?AGTTTAGAGT?TTTATGAAAT?AGACAACAAC?ATGCTTAAAA?AAATCAACAG 840

CTCTAAAGCC?CTTGTAGGCT?CTAAAAAGGG?CGATAAAACT?TTAGAGGGCG?ATTTGGCCAC 900

GCCTATTGGA?GTGTATCGTA?TCACGCAGAA?ATTGGAGCAC?TTGGATCAAT?ATTATGGCGT 960

CTTGGCTTTT?GTAACGAATT?ACCCTAATTT?GTATGACACC?TTAGAAAAAC?GCACCGGGCA 1020

TGGCATTTGG?GTGCATGGAA?TGCCTTTAAA?TGGCGATCGG?AATGAATTGA?ACACCAAGGG 1080

CTGTATTGCG?ATTGAAAACC?CGCTTTTAAG?CTCTTATGAT?AAAATATTAA?AAGGCGAAAA 1140

AGCGTTCCTC?ATCACCTATG?AAGACAAGTT?TTTCCCCAGC?ACCAAAGAAG?AATTGAGCAT 1200

GATTTTAAGC?TCCCTTTTTC?AATGGAAAGA?AGCCTGGGCT?AGGGGCGATT?TTGAACGCTA 1260

CATGCGTTTT?TATAGCCCCA?ACTTCACCCG?CTATGACGGC?ATGAAATTCA?ACGCTTTTAA 1320

AGAGTATAAA?AAAAGGGTGT?TTGCGAAAAA?CGAAAAAAAG?AATATCGCTT?TTTCTTCTAT 1380

TAGCGTGATC?CCTTACCCCA?ACTCCCAAAA?CAAACGCTTG?TTTTATGTGG?CGTTTGACCA 1440

AGATTACAAA?GCCTACCAGC?AAAACAAGCT?CTCTTATAGC?TCTCATTCTC?AAAAAGAACT 1500

CTATGTAGAG?ATTGAAAACA?ACCAAGTGTC?TATTATAATG?GAAAAATAGG?GCTTTGCTTT 1560

AATTGGGGCA?GTCTAAACGG?ATTTTTTAAC?CCATTCAGCC?AAGCTTGATA?CAAGTTTGAT 1620

TAAAAAAACT?ACAGAGCTTC?CATGGCTTTT?TCATAGCCAA?ATTCTGCGGA?TTTTTGCAAG 1680

AATTTTTTAG?CCCTACTTTT?TTGTTTTCTG?GTGCCAAGCC?CTTCTTTATA?AGCGATCCCA 1740

ATTCTATAAA?GGATTTCCCC?CATTTGTTGT?TTGAGTAAAG?TAATATTGCT?TGAAATTTCA 1800

GCAATGTCTT?CCCAAAGAAG?TGTCTTATCT?TTGATTTGAG?TGGATTTATT?AACAAGTATT 1860

CCAAATTTCT?TTCCAAATTT?TATAGGATTC?GCGCTCAAAC?TTGAAAGATC?AATGAATCGC 1920

GATCCAATAA?GCATACTAGT?AAATTCCGCA?AGGTTTGATC?CAAACTTGTT?AGCAAAATTT 1980

GTGCTTTTAT?TAGAAAATAT?GCGAACCACA?TGCCTGTAAG?TCTTAAGCGC?TTGTTTCAAA 2040

TCCTTTTTCA?TCCCTAAGCC?TTGCGCTTGC?ATGCGTCCTA?AAATAAGAGC?GCCCCCTAAC 2100

AACCCGCTCC?CATACCCTTT?GATAGCGTTT?TGTGCATAGA?GTTGCGCTTT?TTTGTAATCC 2160

ACTTTCACGC?CCTTTCCCTC?CAAATACATT?TTGGCTAAAT?AAACGCTGCC?AAGCCCAATG 2220

CTGTATTCTT?GCGCCAATTT?AAAATCTTTA?AAGGCTTGTT?TGTATTGGCC?TTGATTAAAA 2280

TGGTCTAAAC?CATTTTCAAA?ATAATATGTC?TTATGATTTC?GTGCAATTTC?ATCCCACTGA 2340

TTTCGCGCCC?TTTCATCCCA?ATCATCACTT?ATGCTAATAT?ATTCATCAGC?TATACAAAGC 2400

GAAAACGGCA?ACAATAAAAC?TAGTAAAAGC?AATAAAGGCT?TTAAAAAAGA?GAGGGTGGTG 2460

CGATAAAAAT?CTTTAAACAT?GTCAAGTCTT?TTTACAATTT?GAGCCATTCT?TTAGCTTGTT 2520

TTATCATCTT?TTTTAAATTA?CAAACAACAG?CATAATGACA?ACATGGAGAT?GGTTTTATAT 2580

TTTTTGCTAT?AATGGCATGA?ATTTGTTTCA?TAGTAACAAA?TTAAAAATAT?ACCATTATGG 2640

AGGTAATGCT?ATGGCTGACA?CAATCAATGC?AACTGAAGCA?ACTCATGAAA?CAAAAAAACC 2700

AAACGCTTTT?GTAAATTTTT?TCAAAAACAA?TTTGACTGAT?AAGCGTTATG?ATGCATTAGG 2760

TCTCATTGGA?GCAGGGGTTT?TATGTTGTGT?CTTGAGCGGT?GCTATGGGGA?TTGTTGGGAT 2820

AATTTTTGTC?GCAATAGGAA?TCTTTTTGTC?TTTTTCTAAT?ATCAACTTAG?TGAAATTAAT 2880

TGAAAAATTG?TTCAAAAAGC?AATCTAAAGC?GGCAACAACT?GTCAATAACG?AAACCCAAAA 2940

ATCTCAAGCA?ACAAGCGTTA?CCAACGAACC?AACTGAAGCC?AAAGAGACTA?AAGATTGAGA 3000

CAAAACAACG?ATTTTGACTG?AAGAAAGAAT?GAGAGAAAAT?TTCAAAAATT?TAGGCGTTGT 3060

AGTGGTTTAT?CACTCACTGC?ATGACCCACA?CAAGCGACCT?ATAAATTCTT?TTTCTCTAAA 3120

GACTTCTAAT?ATCATAGGAT?TCTCTATTTT?TATCTGCAAA?CACGCACAAA?AAGAAATCAT 3180

GCAAAAAGTG?GCTTCAAGAC?ACACTGACGA?TTCAAATAAG?TTCAACATCA?AACCCAAAGA 3240

AAAGATTGAT?GAGAATGTCA?TTAACGCATT?AGAGACAAGT?TTGAAATCTA?AAGGGGTCGT 3300

TTCAGAAACG?CTAGAAAGTA?TCAAAGAAGC?TAAAAACAAC?AAAGAGTATG?AGAATTTGTC 3360

CAATAGGGGG?TTTTTAAGGG?CTAAATTGGA?TCAAGGGGTA?TGGATCAACT?TTCAGGAGTC 3420

TCTAGGCTAC?AACTTGAGCA?CCCTACAAAA?AAAGGCAATC?TCTCTGTTAA?AAATCAGCCC 3480

CAATCAGATA?TTAGAATTAG?TCCAAAAACT?ATACATGAAA?GGGCATATAA?GCTATCCTAC 3540

TGAATATTTG?TTTGAAGAGA?CTTTCAAAAA?AAACTTATAT?AAGATTTACA?AAGACTCAGA 3600

AAATGATTGC?TTCAACAAGA?ATGTGGCTGA?TGAAGAAAAA?GTTCTTTTAG?AGTTTCCTAG 3660

CAGAAAATTC?ACTCCCAATG?AGCTTTTTAC?AGCTGCATTA?CTTACCTTAA?ATGCAATGGA 3720

ATTTTGTCTC?TATATCAATT?CTGAAAAAAA?AGGAAACTAA?TGTTTAGAAA?ACTAGCAACC 3780

GCTGTATCGC?TCATGGGCTT?ACTAACCTCT?AACACTCTTT?ATACTAAAGA?AATAAGTGAA 3840

GCCGATAAGG?TCATTAAGGC?CACTAAAGAA?ACTAAAGAGA?CCAAGAAAGA?AGCTAAACGA 3900

CTCAAAAAAG?AAGCCAGACA?GCGCCAACAG?ATCCCTGATC?ATAAGAAACC?TCAATATGTT 3960

TCTGTTGATG?ACACAAAAAC?TCAAGCGCTT?TTTGATGTAT?ACGACACCTT?GTATGTGAAT 4020

GACAAAAGCT?TGGGGGATTG?GTTCGGCAAT?AACGCTCTGA?AAGACAAAAC?CTATCTCTAC 4080

TCTGAGGATC?TATTGAATTA?CAACAACTAT?CTATACCTAG?AATACCCCAT?TATCAAAACA 4140

CGAGCAGTGG?GAACCTATGC?GGATCTGATC?ATCATCACAG?GCTCACTAGA?ACAAGTCAAT 4200

GGGCATTACA?ACATGCTAAA?AGCGCTCAAC?AAACGAAACG?CTGAGATTGT?CTTAAAAATC 4260

AATGAAAACC?TGCCTTACGC?CCAAGCGACT?CTCTTGATAG?TGCCAAATAG?AAGCGATCCC 4320

AATGCCCATA?CGCTAGATAA?GGGAGCGTCA?ATTGATGAGA?ATAATCTTTT?TGAACAACAA 4380

AAACGCGCGT?ATTTCAACTA?CGCCAACGAT?GTGATCTGCA?GACCCAATGA?TCAAGTGTGT 4440

TCGCCTGTGA?GTAGATGCAG?AGTGGTAGCT?ATGCCCTCTA?GCGATAGCAG?TGCTCAGAAA 4500

CCTAAGAGCA?TTGCTCATGA?TAGCTTGTAT?AGACTACAAG?AGTCAGATAG?CGCCAATGAG 4560

GCTCAGCCAT?CGCTNAAGTG?CCACTCAGCT?CCGCTCCTGA?AAACAGCGAA?GAGAAGCTCA 4620

TAGAAAGAGC?TAGTCGCTCA?CTCCCTCCTC?AGAGCCAATG?AAGAAGAGAG?GGAAAAGAAA 4680

CTCTTAGCAG?AAAAAGAAAA?ACAAGAGGCT?GAATTGGCTA?AATACAAGCT?CAAAGACCTA 4740

GAAAATCAAA?AGAAACTAAA?AGCTTTAGAA?GCAGAGTTGA?AAAAGAAAAA?TGCTAAGAAA 4800

CCTAGAGTAG?TGGAAGTGCC?TATTTCTCCT?AGAACAAGTA?ATCCTGATGA?AACAATGAGA 4860

GTTGTCAAGG?AAAAAGAAAA?TTATAACGGA?TTGTTAGTGG?ATAAAGAAAC?CACGATCAAA 4920

CGAAGCTATC?AAGGGACTTT?GATTAGTGAA?AATTCTTACA?GCAAAAAAAC?ACCTCTCAAC 4980

CCTAATGACT?TGAGAAGCTT?AGAAGAAGAA?ATTAAGAGCT?ACTATATTAA?GTCTAATGGC 5040

TTGTGTTATG?CTAATGGCAT?CAGTCTCTAT?GTCAAAATCA?AAAACGACCC?CTATAAAGAG 5100

GGAATGCTGT?GTGGCTATGA?GAGTATTCAA?AATCTGCTCT?CACCTCTAAA?GGACAAGCTC 5160

AAGTACGACA?AGCAAAAATT?ACAAAAAGCG?TTACTGAAAG?ATTCAAAGTA?AGTTAAAGTT 5220

TTGTTTGAAA?AATGGATTGG?TCTCTTTTTA?CTTCTTAATT?CCTTAGCCTA?TCCATGCCAA 5280

AAAGTAACCA?TTAGTTTCAA?GCAGTATGAA?AATCTTATCC?ATATTCACCA?AAAAGGTTGC 5340

GATAATGAAG?TGGGTGTGCA?GAACGCTCAT?CTCTATCGCT?TTATTGGAAA?GTTCTTTAGG 5400

GTTGAACAAC?AGCCGCAAAA?TTTCTTTAAA?GACACTTTCT?ATTCCATTGT?TCACATAACT 5460

TTGAACACCG?CTAAAAAATT?CTACCCCACC?TATTCTAAAA?CGCTTCACAA?ATACAAATTG 5520

CTCAATGATG?TGGATTTTGC?GATTTCATTG?GCTAAAAGAA?TTTTGAAAGA?AAATTTTGAT 5580

TATTACAAAC?AAAAACCACC?CCAATAAAAG?CGTGTATCAA?ATAGTAGAAA?TGGCAGTAGG 5640

CGCTTACAAT?GGGGGAATGA?AACACAACTC?CTAATGGCGC?TTATGTGAAA?AAGTTCCGCT 5700

GTGTCTATTC?TCAGGTGCGC?TACAACGAGT?AGGGCATACT?AATTTTACAA?GCAATCTTGA 5760

TGATACACTT?CTACGATCTT?ATGAATTTAT?AATAATATCA?TTTGCATCAT?TATCTTTTAA 5820

TTTTTCTAAA?ATATATTTTG?CTTCTTTTTG?TTAAGATATT?TTGTCTTTTT?ATTTTTTGGA 5880

ATAGGCTTTT?TGCCTTCCTT?ATAAGGACAT?ATAGCGTAAG?AATTTTTCCA?ATTCATACGA 5940

TTTTGGCATA?GGTGCTGTAA?AAATGGATTG?ATGAATTTTA?ACCTAGCGCA?TGCAAACAAT 6000

CCACTAGAGC?GATGTTTGGC?AAATCAAAGA?ACACACAAAT?CACAGTTCGC?TTGAACCCAC 6060

AGGCACTAAA?GATTTATCAT?AGCTCAATTC?GCCTCTAGTT?TTAGCGGCTT?GCAAATCATC 6120

ATAGAATGTT?GCTTGATTAG?GCACTTTCCC?TAATTTGTAT?TTCTTGCTCA?AGCTTGGACT 6180

TACCTTAATA?AGCTCATCAG?TGAAGAATGG?ATCATCATAG?TAAAGCGCCT?TGTGGCACTT 6240

GATGGGTTTG?AGCGTGTTTT?CTAGAATGAT?AAGCTCATCG?CCCATAGTCA?TCAATTCATC 6300

AGGGGTCATC?AAAAACCGCT?CCTTGTTGCT?GATAGAAGTA?TTGGTCTTAC?CGGTATTATC 6360

ATCAATGCTT?CGGCTCACAT?CTTGTCTAGT?GTATTTCCCT?AACACCTTAG?AAAGTTTTTC 6420

AAAATGTTCA?TAGTAGTTAT?CGTTGTTAAT?CCCATAATAC?ATATTCAAAG?AAAGGTTGTC 6480

TAAAATAGTC?TTAGCGCCAT?TCCTACCATA?ACCAAGTGGG?GGGTCATTCT?CTAGTTGTGC 6540

CTTACTTTGA?AACACAAACG?CAGGGCGCAT?GTTGTATTCT?GCCATAATCC?CTACCGCTTT 6600

AACAAAGGTC?TCTAAATAGC?CACAAAGCGT?AAATTCGTCC?ATGAGCATTA?AACAACTTCT 6660

TTTGCATTGT?GGATCATGGA?TTGGCAGAAT?AAGGTTGCTA?TAAATCATCA?CATTGAAAAA 6720

CAGCTCTAAT?ATCGGCCCAA?CAATAGTGCT?TTCTTTAGGA?TTAGCGATCA?CGCCAATACT 6780

CACTTCATCA?ATCCTTAAAC?GCCTGAAATC?AAAATCATTA?GCGCTCGTGA?AATTTCTGAT 6840

CATGGCGTTA?TTGTAGGGGG?CAAACGCTGA?AGTATAGACC?CCTTGGACAG?AGCTGTAAGT 6900

TTCTTTAGCA?CCGCCCATTG?TCTTGAAATT?ATTCCACATG?TTTCTAGTGG?CAGGACTAAG 6960

CACTCTTATA?TTATCGCCAC?TTTTATCTTC?TTCACCTCCA?AAAAATTCCA?TCAGAGACAC 7020

GACTTTTTCC?ATGTTTGTTT?CTTCATCAAT?CAAGTTGATA?CCGCTTGCCA?TAGAACCTAT 7080

GAAAAACATC?GTGGGGGTTT?CAGGCATGAT?GATTCTTTTT?CTTTTGACAA?ACTCAAGCCC 7140

CTTTTTAGTC?CACATAAGAT?CCCTATAAAT?ATTGCAATTG?ATGACAAAAA?GGTTTCGCGC 7200

TTGATTGCTA?AAAAAAGGAT?CTTTTTCATT?AGGTCTTTCA?GGGAACACGA?GCTTTGCTAA 7260

TCCAAAGATT?TGAGTGGAAA?AATCCCCCCC?ACTAGCCACC?ATGCCATGCC?CTTTTAGGCG 7320

TGTGTCAATT?TGAGAGAGTA?TGTCTTCAGT?CAAAACCACA?TCATTACCAA?AATCCACATA 7380

AGCGAAAGGA?TTAAATCGGT?GTGTTTTTAA?GGAGAAAGGT?TCATAGATGA?ACACTTTTTG 7440

GTTGAAGCGT?TTTTCTCTGA?TTTTTCCGCA?AGTTTCCATA?GTGTCAGCCT?TAGGGTCAAA 7500

CACAACGATA?TTTTGAGGAT?AATTGATCAT?ATTGGGCATG?ATGAAACCCA?CCCCCTTACC 7560

GCTTCTGGTA?GGAGCAATCA?AGCCAATGAA?CGCCTGCCCT?GCGTAAGCGA?TAAAATCCCC 7620

CAAACCACGC?CTGCCTACAA?TAACCTCTCG?TTTGTCAAAG?GCGCGTTTTT?TATTATTGGG 7680

TGTGATGAGT?TTAGCTTTGA?TCATTTTTTC?TTCGCTCTCC?CAACTCGCGC?TACCAAAGAG 7740

ATCATCAACT?TTTTTATTCG?CTCCTATGTC?TCTAGTCCGA?GTTAAGTATT?TTAAGAACCA 7800

CACAAAAAAG?GTAATGAATA?TATAAGAGCA?TAAAATAGAA?CTATATACGA?CTAAGGATAT 7860

ATTGAACCCA?TAAATCTTGA?GTGAACTAAA?ACAAAGCGCC?TTAAAATAGT?ATGCAGGAAA 7920

ATCTTGTATC?GCATAGATCC?ATATATCAAA?AAGATCATCA?TCACTCTCAG?GCAATTTATT 7980

ATCATCATAA?AAATTACCTA?AGAGAATCAA?GAAAAATAAC?CCTGATGTGA?TAAAAGAATA 8040

GGATAGTAAT?AGTGTCGCTT?GTAACCAAAA?GCCAAAGGTT?TTAACTCTTT?CTTTCAGCCC 8100

ATCTATAATG?ATTTCTTTAA?AGTTTTTTTT?CTTTTGAGGT?TGGTTAGCTT?TATCTTTAAA 8160

AGCTTTTTTT?TGAGCTTTTA?TGAATTTGTA?GAGAAAAAAT?AACGCTATTA?CCCCTATGAA 8220

ACTAAAAATA?ACAACCAACT?TATAATCCTC?TATGAAATAT?AAGGTGTTAT?ACAACAAGTC 8280

TTCCATTGTG?CCTACTACCT?ATGTTTGATA?TAAAATTCAT?CACACTGTTT?GTGGTGGTTG 8340

ATATGGACAA?TCATATCAAT?TAAATCTTTA?AAGCCCTCAA?TGAGGCTTTC?AAACTTGATA 8400

TTCCTTGCTG?CGTTATTAGA?CGAACTCATG?TTGGCTAAAC?GAATAAACGC?TTCTTCACTG 8460

CTCCCTGCAT?GTAGAGTGGT?TAGCGTGCCT?TTATGACCGC?TACAAAGCAC?ATTATAAAAA 8520

TCATATGCCT?CACTGCTTCT?GAGTTCTCCT?AAAATGATTC?TATCAGGTCG?CATTCTCAAA 8580

CATGACTTTA?AGCAATCAGC?AGAGGTGATA?TTCCCACCAA?AAAAAAGCTG?TGTGTAGTTC 8640

TTGTGGTGTT?TGAATACAAT?CTCTTCGGTG?TCTTCAATAG?ATATGATCCT?TTCTTCTTTG 8700

GGGATAAACT?CCATGATGCT?TTTGATATAA?GTCGTTTTAC?CGCTTCCTGT?GCCACCACAA 8760

ACAATCACAT?TCTTACCAAT?AGCAATACCA?TCTTTAATCG?CGCTGATCGC?TTGTTCTTTG 8820

TTATCTAGTA?GATTATAAAA?ACCCTGCTCT?TCAAAGAAGC?TATGAGGATA?GGTTGTTTTG 8880

CTAGGTATCC?TTATGGATAT?GGAAATGGTT?TCATCATTAA?CTGTAACAGG?GGAAAGGACA 8940

ATTTGCACCC?TTTCACCATT?CGCTAAATTG?CTGCTCAAAA?TAGGATTTTC?ATAGTTGTCT 9000

ATTGTTTTTT?TCTTAAAACT?CGCACAACAC?CGAGCAAAAT?GCATTAAACG?AGACAGACTA 9060

AAGGCTTTCT?TGTCTCTCAC?ATCAAATGGT?TGCCATTCGC?CATTATTTTT?TAAAACCCAT 9120

ACAACCTTGT?TCCCATTGTA?ACAAATCTCA?GTGATATTTT?CCATTTTTAA?AAAATCACCA 9180

AAAAGTTCTT?CAGTAGCATG?CCTTAGAGGA?TTTAATGCCG?CTTCTTTTAA?AGCTCTTTCT 9240

ACTTCTAGAA?ATTTTTTATC?TTCTGCACTC?AATCTGTCTT?CAGTCATATT?CTTATTCCAC 9300

ATTTAATTTT?AATTGGGTTA?TCAATTTAGC?TCTTTCTAAA?GAAGTGAGAT?AAGTCTTATT 9360

TTTGCTCAAA?ATAATATATT?TAGTCCCTAT?ATCTTGGACA?ATCTCATTGA?GCTTCCTTCC 9420

AAAATCATCT?ATCCCTAGAA?TCTGAAACGC?CACGCCCATC?ATATTGCCAT?CTATGAATGG 9480

CGGTAAATAT?TCTCTTGGCA?GATAAGAAGC?CACTAGGTCT?GAAATTCTTG?CTACTTCATC 9540

ACACATAAAA?TTATTGAAGT?TGTCAGAAAT?TTCTGCAACA?AACTCCCCAA?GCGTTAGTTC 9600

ATTTTTGATT?GTGCTTTCTG?CAAAAGTCTT?TTCTTGTTTG?CAACGATTAT?AACTGGCTAA 9660

CACAAGGTTG?TTCAAATAGT?TGTAATAAGC?ATCAAAACTA?ATAAAATTCT?TTTGCATATT 9720

GATTCTTAAC?TCTTGAACTC?TTCTCAAAAA?ATCTTGCGGA?TCGTTGCTAT?CTTTTAAAGA 9780

AGTGGCGTAA?TTTTGAATAA?ACTTATCCCT?TACTTCATTT?GCATTTCCCA?TAAGAGATCT 9840

GTTGCTATCT?AAGATTTTTT?GTCTTTCTGT?TTCATTGAAA?CCGAGTTCCA?TTGCTGTTTC 9900

CTTTCATTGT?TTTTGCTTGG?TTTTTTCCGC?CACTACATTC?TCTAGAAGAG?CCTGTTGTTG 9960

GCTTTGTCTT?TTATCTTGTA?AAGAACCAAG?TTTGGTAGCA?TAGATATATT?TTATCCTTTC 10020

TTTTGAATTA?ATTGCCACCT?TTGGGGCTTG?TGGTGATTTC?TTCATGCTCT?CTAGACAAAG 10080

TTTTAGTGCT?TTGTTTGATA?ATTTCATCCA?CCACAGATTT?GTTGGTAATT?TTAACATCAT 10140

ACACGCCACT?AAAATCAATA?TCGTCCATTG?TGAGAATCTT?AATACTATCG?CCCTCATTTT 10200

TGTAAAAACT?TGGGGGGATA?TTCATCAGTT?GCCCTAGAAT?TTGATTAGAC?ATCTGAGCTG 10260

AACTTTGCAT?ACTACCATTG?ATAGCTTGAC?CCAAAGCGTA?ATTAAATTCA?GGTGTCCTTT 10320

CACTTCTACC?TTTGCCAAGG?CCTATGAGTT?TATCTAGAGC?TATGATAGGT?GCAGTTTGCA 10380

AGAAGCTATT?AACCACGCTT?GCTATCACAG?CAAAGCCTAT?GCGCTTCATG?AAGTGATTGT 10440

TCACATAGCC?ATCTACCCCT?GCTTCACCCA?GCATGCCTGC?TGCTTGAGCG?TTTGCTAGAG 10500

GTATCACCAC?ACCATCAGGC?GTAATGGCTT?TAGTAAAGAC?TATCATTAAG?CGTGTCATAA 10560

TGGGTGTGCC?ACCTTTCACG?CTTTGATAAT?TCCCATACAC?CTTAGTGCCT?TTGTCTAGTA 10620

AGATCATAGT?GCCGTTCATG?TTCCATACAT?CTTTGGCTAC?AACCCCACTC?ACTATACCTG 10680

TGAGAGTGGC?ATCTACTTTA?GAAGTCAGAG?TGATTTCAAT?AGGGGTGTAT?TGCGCTAAAA 10740

CAAATGTGGG?ATCACTCTTG?CCTATAAAGG?CCTGTTTGAC?AGGGCTTGTT?TCATCTTGTG 10800

TTTCTGTTTT?CTTTTTGTCA?TCAACGGAAT?TACCATTTTC?ATCTACAAAT?TCCCCACTCT 10860

TTTCTTTTTT?GTTCTTAAGA?GCGATTTCAC?TGATATTCTT?GGCAGTTTCT?GCGACATCTT 10920

TGTCTATCTT?ATTGCTTTCT?ACTCTAGCTT?CTGCTGTGGA?TTTTTTACTT?TTTTCTTTAT 10980

CGTCATCTTT?TTTATTGCCA?CCTAAAGCCT?TAGCTAATTT?AGCTTCTAAA?TTCTTATCCT 11040

TAATGGTTTT?TTCTGTTTCG?TATTGCTTAG?TAATATCAGG?CTCTATGGAA?GCATAAATAG 11100

GATTATCGCT?AGCTATTTTG?TCCGCATCAA?CATTAGTGGC?GTTAATAGTG?GCAATATCGC 11160

CGCCATTTTT?GAAATCCATT?GGCAACAATG?GATAACCTTT?AGCCGCCATG?TTGTCAAAGG 11220

TTTTGCGGTT?TCTTAGATCG?CTATAAATCA?GATCCACTTC?ATCAGCTTGT?CGTTTAATTC 11280

CTAGAATTAG?CGCCCTTTCA?CTATCGCTCA?AGCCCTCTAA?ACATTGCTCT?ATGGCTTCTT 11340

GATCAGTAGG?GTCATCTAAG?TTATCCAAGC?ACTCGCTTGC?TTGATGCAAT?CTTTCTGTTT 11400

TACTCAATTG?ATTTTGTTTG?CTTTGTGTCC?TTTTATTTTG?GATTTCTTGG?ATCAAATCGC 11460

TATAAAGGTT?TTGACATTTC?CTTTTTTCTT?CATCGGTCCT?AGCCGTTTTC?AAACAATCCA 11520

AGACAGCCTT?TTCTCTAGCT?TCTTGCAGGT?ATTTGAGCTT?CTCTTCATCG?CTCAAACCAT 11580

CCAAACACTT?CATAATAGCC?GCTCTGTCGT?TAGGATCGGC?GTTTTTCAGC?ATCTTTGATC 11640

GCTTTAC 11647

<210>120

<211>26344

<212>DNA

<213>H.pylori

<400>120

TGCGACATCT?TTGTCTATCT?TATTGCTTTC?TACTCTAGCT?TCTGCTGTGG?ATTTTTTACT 60

TTTTTCTTTA?TCGTCATCTT?TTTTATTGCC?ACCTAAAGCC?TTAGCTAATT?TAGCTTCTAA 120

ATTCTTATCC?TTAATGGTTT?TTTCTGTTTC?GTATTGCTTA?GTAATATCAG?GCTCTATGGA 180

AGCATAAATA?GGATTATCGC?TAGCTATTTT?GTCCGCATCA?ACATTAGTGG?CGTTAATAGT 240

GGCAATATCG?CCGCCATTTT?TGAAATCCAT?TGGCAACAAT?GGATAACCTT?TAGCCGCCAT 300

GTTGTCAAAG?GTTTTGCGGT?TTCTTAGATC?GCTATAAATC?AGATCCACTT?CATCAGCTTG 360

TCGTTTAATT?CCTAGAATTA?GCGCCCTTTC?ACTATCGCTC?AAGCCCTCTA?AACATTGCTC 420

TATGGCTTCT?TGATCAGTAG?GGTCATCTAA?GTTATCCAAG?CACTCGCTTG?CTTGATGCAA 480

TCTTTCTGTT?TTACTCAATT?GATTTTGTTT?GCTTTGTGTC?CTTTTATTTT?GGATTTCTTG 540

GATCAAATCG?CTATAAAGGT?TTTGACATTT?CCTTTTTTCT?TCATCGGTCC?TAGCCGTTTT 600

CAAACAATCC?AAGACAGCCT?TTTCTCTAGC?TTCTTGCAGG?TATTTGAGCT?TCTCTTCATC 660

GCTCAAACCA?TCCAAACACT?TCATAATAGC?CGCTCTGTCG?TTAGGATCGG?CGTTTTTCAA 720

GCAATCTTTG?ATCGCTTTAT?CTTTTTGTTG?GAGTTCTTTC?GCTAAAAATT?TTCTCGCTTC 780

AGGGGTGAGT?AATTTCTCGC?ATTCTTGTTT?CTCTTTTTCA?TTCCTAGCTC?TTGAAACGCA 840

GTCCAAATAA?GCCTTAACGC?TCTTCTTAAC?TTCTTGCTCT?AAGAGTTTTC?TCGCTTCAGG 900

CGTGAGTAAC?TTCTCACAAG?CTCTCCTTTC?TTCTTCATTT?CTAGCTTGAG?AGAGGCAGTC 960

TTTATAAGCT?TTAAGACTCT?CTTTAGCTAA?AACATTTTTC?TGTAAGTCTT?TAAGGATATT 1020

TTTAAGACAT?GCTTTTCTTT?CTTCTTCATT?TCTAGCTTTT?TCAAACAACT?TAGCACTTGT 1080

TGCTCTAAAA?ATTTTCTCGC?TTCATGCGTG?AGTAATTTCT?CGCATTCTTT?TTTCTCTTTT 1140

TCATTCTAAG?CTTTTGATAC?GCCATCCTTG?TAAGCTTGNA?CGCTCAAATC?AGCTAGTAGT 1200

TCTTTTTGCA?AGTCTTGGGG?AATATTTTTC?AAGCATTCGT?NTCGTTCTTC?ATCGGTTTAA 1260

GCGTTTTTCA?AACAATCTAG?CGCTTGTTGT?TTCAATCTTT?CTATAGCTTC?TTTAGACAAG 1320

CCTTTCAAAC?ATTCGTTTTT?CTCAGCTTCT?GTTTTGGCGT?TTTTGATACA?ATCCTTATAC 1380

TCTTGAATCT?CTTTTTGAAT?CCCTAATTCC?TTACGGAATT?TCTCTCTAAT?CTCAGGGTCA 1440

TTTATGAGTT?TTAGGCACTC?GTTTCGTTCT?TCATCGGTTT?TAGCGTTTTT?CAAACAATCT 1500

AGCGCCACTT?GAACTTTTTG?TTGGTTCAGT?AAGCTTTTTT?TTAGGTTTTC?ATCTTTGATT 1560

AAATCTAAAC?ACTTGATCCT?TTCTTCTTCA?GTCTTGGCAT?TTTTGATGCA?GTCATTATAA 1620

GCCTCTAAAG?TCTTTTTCAT?TTGATCTTGA?AGTTTTTTGT?CTTTGATAAG?CTTCAAACAT 1680

TCTTCATAGT?TGCCACCATT?ACTAATACAT?TCATAAAAGG?CCCTCAATGG?GTTTTTGTCC 1740

TCAATTTCTG?CAATATTCAA?ATAGTTGTAT?AGGGTTCTAT?TGGGATCGTC?ATTGAGGAAA 1800

AGATTCTTAT?CGATCATATT?GCCTTTTTCA?TTCCGTTCTT?TCAGCAATCG?GTTATACTCT 1860

TGCCTTATTT?GGATTTCATC?ATTGACATAA?AGATTCCTGT?CTTTGCTAAA?ACGAGAGCTT 1920

TTATCTTCCA?AAGGTATGAA?GTAGTGAAAA?ATGCTTCTAG?AAAATAAAAT?AATCACAATA 1980

AGAACAGCGA?CTACAATGCC?ACCAATAATG?TATTTCTTTT?TGCTTCCTTT?GATAATCTCT 2040

TGATCGTTAG?AATCGTTAGT?TATTTCTTCT?GACTCGTATT?CATCAAAATT?GGTTTTAGTT 2100

TCTGTGGGGT?TGTCAAGATG?ATGATCTGAG?CTTTCTTCTT?TTGAAGAATC?TTCAAAGTGA 2160

TTGGCTTCTG?TTGCTTCTTC?ATTGGATAAA?TCTTGGGGTG?AATGTTGTTG?GGTTTTTTTA 2220

GAAGTTTCAT?CATCAATTAA?GTCTATTTGA?GTTTCTTCTT?GATACCCATT?ATTTTCTTGA 2280

TCGTCTTCTT?CGTTCGGTTC?TTGGATTTCT?TCATCTAAAT?TCTTTTGCTG?AGTGAAAGGT 2340

CTTTTATCAT?TAACTAATTT?TCTGGCTTTC?TTGAATAACT?TGTCTGCTAG?ACTGCCATTG 2400

CTAGATTCTG?AAGTTTCATT?ACCTCCAGAA?TCCATTTGAG?TTTGGGTTTC?TTCTAGCTCG 2460

TATTCATCAA?AATTGGTTTT?AGTTTCTGTG?GGGTTGTCAA?GATGATGATC?TGAACTTTCT 2520

TTGGATTCTT?TTGAAGAATC?TTCAAAGTGA?TTGGCTTCTG?TTGTTTCTTC?ATTGGATAAA 2580

TCTTGGGGTG?AATGTTGTTG?GGTTTTTTTA?GAAGTTTCAA?ATTTATCGTT?TTCTTCATTC 2640

ATGTCTTAAC?GCCTTTTTAT?TTATCTCTGA?CAAGAGGGAG?CTTTTTAATC?ACACGCTCCA 2700

ATTCACCATA?GTTTTTGATA?TTGTAATTTT?TTGTCAATGG?ATTTTTCCCA?TAGCCTTTAT 2760

TTATTACTGT?TACAAGGGCT?TTGTCTTTAA?TGAGCTTAAA?CTTTTCTGCA?ATTTCATTAA 2820

CTCTATACCA?TCTCAATCCT?GAATTGGTCA?TGTTAGGATC?AATGGCAGCA?TCAGTCATGC 2880

TCAATTTCCC?ATCAGGTTGA?ACCACAAAAA?TAGCAGGTTG?GAGAGTGATG?TTTTTGAAAC 2940

CAAAATAAGT?GAATGTGCCA?TCATCAAAAA?TTTCAGAGGG?CATAATATGC?TTAGAGTGTT 3000

TTTCAGGCGC?TTGGTAGTAA?TTGTAGTTTC?TAGGCACAGG?GTTTCTTTTT?AATGCATTAT 3060

GCACATATTG?AGTCTCTAGC?GCCTTTGCTT?GATCTAAAAT?AATTTTTTGT?TTTTCTTCTC 3120

TTATTTTTTC?TTTGTTGATA?ATCTGTTCAT?TGCTCGCCAT?CATTACTCTA?TTGATGTAGG 3180

CTGTGGTATT?AAGATTTTCT?TGTTTGATCA?ATTCTCTCTG?CCTTTTTGCT?TCTTCTCTCT 3240

TTTTTAACTC?CTCTTCAATA?ACGCTAGAGA?CTTCGTGTCT?TTGTGGGTAT?TCTAATTTGA 3300

CTGTTAGATA?CGCCGAAGCA?AAATTGTCTT?TTTGAGCTAT?TCTCAAAATG?AATTGATACA 3360

AGGCTTTATT?AGTCCGCACA?ACAAGATTAG?TTCTCCAAGC?GCTATCGCTA?GGAGATAATT 3420

CTATGGAGTT?ATCCTCAGGG?CTTTTTTGAG?ACTTATCTGT?CTTAATATTG?ATTTTATCCT 3480

TGGCTCTTTG?TTTCACTGCC?TCTTCAGCTT?GTTTTTTGTT?GAGTTCTTCA?ATTTGTTTGA 3540

GTGCATTAGC?TTGAGCCTGT?TCTTGCATGT?CCTCTAGTCG?TTCCATTTGG?TCTAATTCAT 3600

TTTCTCGTTG?TTGCTTGATA?AATTCGCTAA?GATTTTTGTT?ATTGCTCAAA?TTTTGTGGGT 3660

TACTCATAGC?GTTAGTGAGA?TTTTCTAAAT?TGGCTCTATT?TTTTGCACGC?TCTTCCTTTC 3720

TTTTTTCTCT?TTTATCTTTT?TGCGCTTTTT?GCGCCTGTTC?TTTAGCTTCT?TTTTCTTTTT 3780

CTAGAGCTTT?TTTTTGTTCT?TCTAGTTCTT?TAGGGTCAGG?CGCATCTACG?ATAAGTTTTT 3840

TTGTTTTTAA?AAATTCTTGG?TAATCTCTTG?TCATTAGGGC?AAAATTCACT?GCTTCTTTTT 3900

CAAACATGAG?ATTACTTTTT?ACCGATTTAG?GTTGAATGAA?TATATGATTA?GAATTAGGCA 3960

CAATACTCCA?ACCTTTATTG?AAACCTGTTG?TGATGTAAGA?AATAGTTTCA?TCTTTTTCAA 4020

GTTGGATCAC?AGTAACATTG?TCTAATGAAG?TCCAAATCGT?AATAGGTTTT?TCATCTCCCA 4080

AATAAGCAAT?CTTCTTATTC?ACCACTTTCA?CCCTACCACG?ATTAAAATTT?TTAATGTCAG 4140

GTGCTGCTTC?TATTACGCTA?GATAAAAATA?AATAACCAAG?ACAGAAACAG?CCAACAATTT 4200

TTTTAAAAAA?TGCCTGCTCC?ATCAACAATT?CCTCTTAAAA?AATATTTGTA?ATTGTAACAC 4260

AAGAATAAAG?TGGCTTATCC?TTTAAACATA?GATCCACCAA?CTCTTCCCAC?CATTAAGGCA 4320

TCTCTTTCTC?TATCCATTCT?GCTACCATCC?ATAGATACAG?AGCTAAAAAT?GGTATTAACG 4380

ATCGCATTGA?CACTCTCAAT?AATCGTCTCT?ATGAAGCCTT?TTAAAATAAA?TAAAGTGATC 4440

AAACTCGCAA?TAGTTGAATC?GATACCCAGT?CCACCTTGAT?TGATGTTTTG?TATAGCAACA 4500

GAGGGCGTTA?TGGTCAAATT?GAATGCCAAT?AATGCCAAAA?CACCAAAGAG?CAAAATAGGA 4560

ATAGCTAGAA?CCAAGATAAA?CAAATTATTA?ATAAACCATA?TCAATATGTT?TTTCATAGAA 4620

TCTTTGAACC?AATCTAGCAC?GATCAAACAT?ACCGCAATAG?GGAACACAAT?ACCGCTAAAA 4680

GCCCCCGCTA?TCAAAGGTTT?CACAACAACA?GTGCTTATTC?TCATAATGAT?AGTTACTTGC 4740

ATAAAAATAG?CGAATAAAGA?AATACCTGCC?ACTTGCAAGC?CTTGTAACAA?ACTAGGAGCG 4800

TTGTTGCCAA?CATTAGAAAA?AACAGCTCTT?ACCGCAGGTA?AAATTGAATT?AACAGTGTAA 4860

TTCAGCACTA?AATCTAAAGC?CCAAAAAAGA?ACTTGATTCA?GCCCAAAAGC?GCCTGCTAAA 4920

CCAAAATAAA?TGGAATAAGA?GATTTTATAA?AGATAACCAA?AACCTGCATA?GGCGATAAAA 4980

GAGACCATCG?CCATTTTGAA?TAATGTCCCC?CCAACAAATC?GCATGTATTC?AAAACCTATG 5040

TTAATCTGAA?TGCCATTTGA?AATATCTCTC?AATTTCATAA?AAGAAATAAA?AACAAAAATC 5100

CCAAAAACAA?TATAAATCAG?GTAAGAAACA?AAATCAAGAT?ATGACCCTTG?CCCTATGATA 5160

ATATCAGGCA?GATTGACTAC?ACCATATGCA?GGAAGAACAG?CAGCGTCCGC?TCCTTTGACA 5220

ACAGATTCCA?GTGCGGCAAA?AGCAAGCATG?GCTGTAGCGT?TGTTTTGCAG?TTTATTTGCA 5280

GTGAATTCTT?TGCCAATCAG?CCAAATTAAA?CCATCAGCTG?TAATATTCGT?AGAAGCTTGA 5340

GCGGTTATTG?AGCTAATTAT?TTGTAAAAGA?ACATTGCCTT?TCACATTGTC?CTCAATACCG 5400

CCTTTGGTAA?AATTCCGAAT?CTTGTTGCTC?AAATTGTCTA?GCACGCTATC?CATGGATACA 5460

TCTATGTTTT?TATTTATCAA?TGCGTTCCAA?CCAAAATTAC?AGCCACTTGA?GGGCGTTAGA 5520

GCAAAACCTT?GTATAGCTGT?AGCAACACTT?GCCCACGCCG?ATCCCCATAA?AGGACCTAAA 5580

GTGTTCAAAT?ATTTCACCAG?ATTGCTAGCG?GCTAAACTTG?TGGCTAATGG?TGTGCTAAGC 5640

GCTTCAATCA?CACCCTGCCC?TGAACTCTTT?CCACTCCCTG?ATGCACCAAT?AGATGTATAG 5700

CCTGTCAAAA?TATCTGCAAA?ACTTTTGTTG?GTTAAAACAT?AACTCGGTAT?CAGCATGCAA 5760

TAAACTGTTT?GGTAAATTTT?GAGATTTGAA?ACAATGGGCA?AATCAATAGC?TTTCAACCAA 5820

TTAGGAACGA?TGAGAAAAAA?ACTTATGATC?GTTATTAAAA?AAGTCCTTTT?AATATTAAAC 5880

ATGCTCTTAT?TGTTTTAATG?CCTTATTTTT?TGATTCCACT?TCTTTAATCT?TTCTCAAAAT 5940

TTCGCTTACC?GTCTGTTCGT?TTTGTAAATC?TGTGATTTGA?ATGTCAAACA?CTTTGAAGCC 6000

AAAAGGATTG?ATGATAAGAT?TTTCTTGAGA?AGAGTTACCT?CTGGCAAAAT?CATAATAAAT 6060

AGTTACTTGT?TTTTTAGTGA?TATATTCATA?ATTTTCCATT?GTATCAGGTG?TGATTTTGAT 6120

GGTAATGAAA?AATGTTAATC?TCGTTAAGGG?ACTATTTTTG?ACTTTTTCTC?TTTGTATGTT 6180

AGAGCTAATG?ATAGCTTCTG?CTCGGACTTT?ATCTACGAAT?TGTCTGATAT?TTTCATTGAA 6240

CATTCTCATT?GCTTGGGTTT?GGAAACTCAC?ATCGCAATAC?TGCATTAGTT?GATCCTTGCG 6300

ATCCCTCAAA?GAATTTTTGC?TATAACCAAA?CAGCAATGAA?ACAAATTTTG?AAGTTGCACT 6360

ATCCACAACG?GCTTCAGAAT?TGACGATTTG?CCTAGCATCG?GAGCGTTTGA?CAATTTTAAA 6420

TTCTCCTGTG?TATCGATCAA?TGCCATAAAC?AAATATATCT?GTTTTCTTCA?AAGGCATCAT 6480

CATCACAATA?CTCGTTACAG?CGGCGACATT?GAGTGCCATA?GAGAGATAAA?AAGCCCTTTT 6540

GAAAGTCCTA?TTGGCCTTAT?TGAGTTTTGC?CAATCTATCA?AGGGCTATCA?CACCCCCAAC 6600

CAAATTTTCA?TCAACCAAGA?CTTCCTCGTT?TTTTTTCCCT?AACATGCGAC?AACTTTATTA 6660

TTTAGTTATT?GGTTCGTTGG?TTGTAAAACT?TGAGAAATAC?TTGAGAAATT?TTTTCATCAA 6720

AAACTCTTTA?AAACAATTTC?AGTTGTTATA?GTATAGCAAA?ATTTCTGTAA?AAATATATAT 6780

TTGAAAAAAC?CTTTAACAAA?AACCTTTTTG?GATAAGGCGT?TGAACAAAGA?TTCCTTATAA 6840

TGAATGTAAG?TAGCGGATTG?CTTCAAACAA?GAAGCAAGAT?GAAACACGAT?ACAACTCAAA 6900

AAGTAAGAGC?AATGAGTAAG?CAGTCGTAAC?TCAGTAATGA?AATTTTAGAA?GCGCTTAATT 6960

CAAAGAAATA?AGACAATCAC?AACTCAGAGA?GAATGGTATA?ATAACAAAAC?AATTTCTCAA 7020

TTTAATTCTT?GAAAGGAGTT?TTATGAACGA?TACAACAGAG?CATCATGGAT?CCAATTCGCT 7080

AAACGCCCCA?TCACCTAGCA?ACTCACAGAG?CAATGATCTT?TTAAATTTGC?TAGACTCGTT 7140

ATATCCCAAA?GGGAGTTTAG?GGGAACAAAG?ATTTCACGAA?GCTTTAAAGA?ATCAAGAAGA 7200

GTTGAAAAAT?ATCCTGATAG?AAATAGAAAA?GCTACCGCAA?GAAAAAAGGT?ATGAACTTCT 7260

GATGCAGATA?GGACAAGCCA?AACAGAGAAT?AATGGAGGCA?TACGCTCATT?CATTCTTAGG 7320

ATATATAGGG?GGGTTAGAGC?ATCTGTTAGG?ATTGTGTATG?GGTGGGATAT?TTGTTTTGTT 7380

TGCAATCTAT?TTTGTATTTT?TAAGAACTAG?CAAAAATGTG?GATTTGGTGG?AAAGTCTAAA 7440

AACAAAACTA?AAACTTCAGT?ATTTTTACTA?TGCCTTTGGT?GTAGGTGCGG?TTTTGTTTTT 7500

TGGATTAGAG?ACAATTAGAT?CTATTTATGA?ACTGTATATA?TTAGGAATTG?GTAGCACTAA 7560

CGATAAGGTG?CTCTTTGTTT?TGAAAAACAT?TTGCTTCATA?GGCATGGGCT?ATTTGATTTA 7620

TAAAGTTATT?AAGGTTATTG?GTATAAAAAA?TTTTATCAAT?GGTCTTTTCA?CTTCAAAGAA 7680

ACAAGAGCAA?TAAGGAGAAA?CAACAATGAA?ACTGAGAGCA?AGTGTTTTAA?TCGGTGCGAC 7740

AATTCTGTGC?TTAATTTTAA?GTGCGTGCAG?TAATTATGCG?AAAAAAGTGG?TGAAACAAAA 7800

GAACCATGTT?TATACGCCTG?TGTATAATGA?ACTGATAGAG?AAGTATAGTG?AGATACCCTT 7860

AAATGACAAG?CTCAAAGACA?CACCATTCAT?GGTGCAAGTG?AAGTTGCCAA?ATTACAAGGA 7920

CTATTTGTTG?GATAATAAAC?AAGTTGTACT?AACTTTCAAA?CTTGTTCATC?ATTCTAAAAA 7980

GATTACGCTC?ATAGGCGATG?CCAATAAGAT?CCTCCAATAC?AAGAATTATT?TCCAAGCTAA 8040

CGGGGCAAGA?TCTGACATTG?ATTTTTACTT?GCAACCCACT?TTGAATCAAA?AGGGTGTGGT 8100

GATGATAGCG?AGTAACTACA?ATGATAATCC?TAACAACAAA?GAAAAACCAC?AGACCTTTGA 8160

TGTGTTGCAA?GGAAGTCAGC?CAATGCTAGG?AGCTAACACA?AAAAACTTGC?ATGGCTATGA 8220

TATGAGTGGA?GTAAACAACA?AGCAAGTGAT?CAATGAAGTG?GCAAGAGAAA?AAGCTCAGCT 8280

AGAAAAAATC?AATCAGTATT?ACAAAACTCT?CTTACAAGAC?AAGGAACAAG?AATATACCAC 8340

TAGGAAAAAT?AACCAACGAG?AAATTTTAGA?AACATTGAGT?AATCGTGCAG?GTTATCAAAT 8400

GAGGCAGAAT?GTGATTAGTT?CTGAGATTTT?TAAGAATGGC?AACTTGAACA?TGCAAGCCAA 8460

AGAAGAAGAA?GTTAGGGAGA?AGCTACAAGA?AGAAAGAGAG?AACGAATACT?TGCGCAATCA 8520

AATCAGAAGT?TTGCTCAGTG?GTAAGTGATT?GGAAGAAAAA?AGGGAGAGAG?TATAGGGTAG 8580

AGAACAACGC?CAATAGGCGT?TAGCCTTACT?TGATAGGTAA?GGCGATCAAG?TAGGTAATCT 8640

TTTTAAAGCG?CTCATCATTT?TTTAATTCTG?TCCCTGCTTG?AGACAAATAT?TTTTCAAACT 8700

GAATTTTGTT?AGTTGCACCG?AGATTTTTTA?TTCGTTTTCC?ACATCAAGCG?TTTTGCACTC 8760

CTTTTTCTTT?CATGTATTTT?TCAAGATCAA?ATTTCATTAG?CAAATCCCTA?ACATAGTCGT 8820

TATATTGTTC?AATGGTTTTT?AGATTAGCAT?AGAAATTCAC?TTCCTCATCT?GTCATCACAA 8880

ACAATTTCAA?TAGTGGGAGT?TTAGTGCCAT?ACAATTCTAT?TTGCGAGTCC?ATTTCTCTAA 8940

TACTCATCTT?GAACATGATG?GGCTTACTGA?AGAAAGGCAG?AAATATTCCA?AGAATTGATC 9000

GATCAAATTT?AGAGAATAAG?AAATTAGGAT?TCTCTGCAAT?CGCATGCAAC?AGCTCCATAG 9060

TCTCACTCTC?AAGCAATCGA?TAAACCTTTT?TAAATTTATC?AACACCAATG?CTTTTGATAA 9120

CAGCGCGATA?ATCTTTCATG?TAATTTCTTA?GAACCTTATC?TAGCGCTCCC?TTGTTCGTAT 9180

GCATCTGTTT?GAAAAAATCA?TGCATGGTTT?TTATTTGATC?TATGATTTTC?TTTTTTTCAT 9240

CAGTGTTTAA?AAGTTCGTTC?TCCTGCAAAC?TCTCAATAAG?TTTTTCTTTC?TTATCTTTTG 9300

AGTCAGCAAT?CATTGAGAAG?AGTTTTCGCA?TGTTGTTACT?CATATCGCTC?TTGGTCCCTT 9360

CAATGGATTT?GGTTTCTCTT?TAGATTGTTC?AAATCGTAAA?GTTTTATATT?AAAATTATAC 9420

AATATCTGTT?GTGTGAAAAT?TTCAGAGTGG?TCATAATTCA?AAGAGCAAGA?AACTATTTTT 9480

TAACCATAAA?ATATTGTTTC?AATCACTCTT?ATATCTATTT?TTCAAAACCT?ACAAAAAACG 9540

CTTTCACAAA?TAGCCCTAAA?AACCGATTTA?AAAAAGTTTT?AATATTATAT?ATTATTTTTA 9600

AAAAGCAAGA?TCAGTTGTAA?AAATGCGTTA?CAACTAAAAT?AAAGAGTCAA?GATAACTCAT 9660

TTTCAAAAAG?GAGTCTTAAG?TAATAAAATC?ATAATGTTCA?GCTAGTAATC?TATTGCCTCG 9720

TTGATCAAAC?AAAGCTCTGC?GTGAAAGATG?AAAAAATTTC?ACCTTTAGAT?AGTTAATACA 9780

CCACTACAGT?CTTACTTGAG?AGACACTCAT?TTTATTAGCG?GTTTTGTCTG?ATTTGCTGCT 9840

ACCAAAACCA?TTACCAACCA?AAGCAGATCC?CATGTTTTTG?ATACTATCGA?ATCCATTCTT 9900

CAGCACTTCT?GCCATAAAAT?TCTTGATATT?GTCCATAGGC?AAGTTAAATT?TTTTCCCTAA 9960

TGCTTCATTA?AGTCCCATCA?TTAACATCAG?AAAGAACAAA?AAATTTAATA?TCATAGAAAA 10020

CAAATCACTG?GATAAACCTG?TAAAAAGATT?TGTTCCGCCA?CCCAACAAAG?AAGCTAAAAT 10080

TTTTCCCATG?ATCAGTCCTT?TTATTTTTGG?TTGTGTAAGT?TCTTGCTTGT?TCGGATCTCT 10140

AATGCGTGTT?TTAGTAGGAA?GCATTTCACA?ATAGCATACC?TAAAGCTACT?AAGAAAATTC 10200

TTGAATCTAT?TGGTAAGATT?ACTCATGAAA?TCAAGCGATA?AGTAGCCACC?AATCGCAAAC 10260

AAATCAAATA?TTTTGCCACC?AAACAAGCCA?TATCCTTTTT?GTTTTTATCT?CCTAATTATA 10320

GCAAATTTTT?ATCAATATTA?ATTTGGAAAA?CCACCACCAT?ATCAAAAACA?AATTACTAAC 10380

ACACTAGATG?TAGAATTATT?TTTAAAAAAC?GCTCACTTAA?ATTTAAAATC?ATGGGGTTTT 10440

AGGATTTGAA?TACCAAAAAT?AGATTGGTTT?TTTCAAATAA?GCTAGCTTTG?TGTATGTGCT 10500

TAAAAAGATT?TTAGTTTTTA?GTCAGTAAGG?TTTTATGCTA?ATGTTTGGAA?ATAAAGAAAT 10560

TTCTCTAAAT?CAAGTCTTGA?GAAATTTTTG?AACGAATCAT?AAGAACCAAT?TTTGCCATTG 10620

AGTCATAAGC?ATGATTAGCT?TCATTGTGAA?GTTTGCGTGG?CTTAAGAGAT?AGTATTTGCT 10680

TATTATGCTG?AGAGAAACGA?GTAGTAAAAG?ATAAGTAGTG?TAACTAAAAA?AGCTAGGTTT 10740

TATTATAAGA?GCAAATAAGA?ATAATATTGG?ATAAACTAAA?ATCACCCCTG?CCCCATAAGA 10800

AAAAAGCCCT?ATTAAAAAAC?CTATGACGAT?AGAGCTGATA?TTGAACAGCC?TATAATAAAG 10860

GCTGTACTTA?TCTAAATGTT?TGTTGAAAGA?ATGTTTGAAT?TGTAAGAAGT?TTTGTTTTAA 10920

TTTGCTAATT?GGCTGTTCCA?TTTTGGTTTT?TAAAGAAATA?GTTCAAGGCG?GTGAACCTAT 10980

AAAGGAGCAT?AAAATAATAA?ATATTTTACA?AAACCACCCT?AATCTAACTC?CAAATCTCAA 11040

AGAATACCCC?ACTTGCTGAT?ACTAACATGT?GGTATAGCAC?AAACCAACGA?CTTGTTTGTT 11100

TATGCTAAAC?AAAGAACAGA?AAACATCTGT?TAAAGAATAA?AGGAGTTTTC?CATCTAAAAA 11160

CACAGATCCA?TTGTATAAAA?ATAATCTTAA?GAGAAACTTA?AAAAATACCA?ACAAGCCGCA 11220

TACAAGCAAG?AAAAACATAA?CACTATAAGA?CCTAGATTTT?ACTTACCTTT?TGGATATGGA 11280

AAAATTTTGA?TCCATAGTTT?TGTAAAAATT?GTGGTAAAAT?GTATTAATAT?TTTTTGAAAT 11340

TTTAAGGTTA?CAAAAACTAT?AAGATGCTTG?CAAAAATCGT?TTTTGGCTCA?TTGGTTGCGT 11400

TTGGAGTTTT?GTCGGCTAAT?GTGGAGCAGT?TTGGTTCATT?TTTCAACGAG?ATAAAAAAAG 11460

AACAAGAAGA?GGTGGCTGCA?AAAGAAGACG?CTCTTAAGGC?TCGCAAGAAG?CTCTTAAACA 11520

ATACGCATGA?TTTCTTAGAA?GACTTGATTT?TTAGAAAACA?AAAAATCAAA?GAGCTTATGG 11580

ATCATAGAGC?TAAAGTTCTT?TTAGACTTAG?AAAACAAATA?CAAAAAAGAA?AAAGAGGCTC 11640

TAGAGAAAGA?GACAAGGGGT?AAAATTCTTA?CTGCTAAGTC?AAAGGCTTAT?GGCGATCTAG 11700

AGCAAGCCTT?AAAAGATAAC?CCTCTCTATA?AGAAACTTCT?TCCTAACCCT?TATGCCTATG 11760

TTTTAAACCA?AGAAACATTC?ACCAAAGAAG?ATAAGGAGCG?TTTGAGTTAT?TACTACCCTC 11820

AAGTGAAAAC?GAGCAGTATT?TTTAAAAAAA?CTACCGCTAC?CACTAAAGAT?AAGGCTCAGG 11880

CTTTGCTTCA?AATGGGTGTG?TTTTCTTTAG?ATGAAGAACA?AAACAAAAAA?GCGAGTCGAT 11940

TAGCTTTATC?TTACAAGCAA?GCGATTGAAG?AATATTCCAA?TAACATTTCT?AATTTATTGA 12000

GCAGAAAAGA?ATTGGATAAT?ATAGATTATT?ACTTACAGCT?TGAAAGAAAC?AAGTTTGACT 12060

CCAAAGCAAA?AGACATCGCT?CAAAAAGCTA?CTAACACGCT?TATTTTTAAC?TCGGAACGCT 12120

TGGCGTTTAG?CATGGCGATT?GATAAGATCA?ATGAAAAATA?CTTAAGGGGC?TATGAGGCTT 12180

TTTCTAACTT?ATTGAAAAAT?GTCAAAGATG?ATGTGGAATT?GAATACTCTG?ACTAAAAACT 12240

TTACCAATCA?AAAATTGAGT?TTCGCTCAAA?AACAAAAATT?GTGTTTGTTG?GTTTTAGACA 12300

GCTTCAATTT?TGATACCCAA?TCCAAAAAAT?CTATATTAAA?AAAGACTAAT?GAATACAATA 12360

TTTTCGTAGA?TAGCGATCCT?ATGATGAGCG?ACAAAACAAC?TATGCAAAAA?GAACACTACA 12420

AGATATTTAA?TTTCTTCAAA?ACAGTGCTTT?CTGCATACCG?AAACAATGTT?GCCAAGAATA 12480

ATCCCTTTGA?ATAGGAAAGG?AGACGCTCTT?GAAAAGTATC?TTCAAAAAAC?TAGGTTCTGT 12540

CGCTCTTTAT?TTTTTAGTTA?TTTATGGGGG?CTTAAACGCT?ATCAATACAG?CGTTATTACC 12600

GAGTGAATAC?AAAAAATTAG?TGGCTTTAGG?CTTTAAAAAA?ATCAAAACAT?TCCATCAAAG 12660

ACATGACGAA?AAAGAAGTTA?CAGAAGAGGA?AAAAGAATTC?GCCACTAACG?CTTTGAGAGA 12720

AAAATTACGA?AATGATAGGG?CGAGAGCGGA?GCAAATTCAA?AAGAATATTG?AAGCGTTTGA 12780

AAAAAAGAAT?AACTCTTCCA?TTCAAAAAAA?AGCGGCTAAA?CACAAAGGAT?TACAAGAATT 12840

AAACGAAACT?AACGCTAACC?TTTTGAATGA?CAACCCTAAT?AGTAATTCTT?CCACTGAAAC 12900

CAAATCCAAT?AAAGATGATA?ACTTTGATGA?GATGATCAAT?AAGGTGAATG?AAGCTTTTGT 12960

GAAACCTGCT?GCTCCGCTTG?TGCCTAATGA?GTGGAGAACA?CCTGAAATTG?AAATCATTAT 13020

CAATGAGTGT?ATTATTTCAA?GCAACGATTA?CGATGGGTTA?AGAAAGTGTT?TGATCAAAGA 13080

CATCAAGGAT?CAAAAAATTC?TTGCCCCCTT?ATTAGAAAAA?ATTCAAGAAA?TAGAGACAGA 13140

AAATAACAAG?TTTTCCAGAC?AACACTTGAG?TGGTTTAAAG?CTCGCTCTTA?ATAACAGCAA 13200

CAATAGAACC?TTTCTTATAG?CTTCATGCGC?TATTTGTGAG?AAGAGAAAAA?AAGAAATGGA 13260

GCAAGAACAT?AACTACCAAG?ATACTACAAA?TGCAAGTGAG?TTTGGAGCTA?CTGACACAAA 13320

AGAAAATGAA?GCAAAAGAAA?ATGAAGCAAA?AGATGCAGCA?TTCTCAAACA?ATCGTTCTAA 13380

ATCTGAACTG?CCCAATAGCG?TCATTAATCA?AATAGAACAA?AGCATCGCTC?ATGGAAAAAA 13440

ATAGCGATCA?AGATTATTAG?CTCAAAAAAC?AACTAGAGAA?ACAAATCCCA?AAGGTTAGAA 13500

ATCATGGTCT?ATTGTCTCAG?AAAAATCATT?TAACAATAAT?CTTACTTGAT?TGCCTTTCTT 13560

GTAGGTATTG?CCGCTTGCTT?TGTTCTAGGG?ATATTTCTAA?TGCGTCCAAC?TTTTCTAAAT 13620

AATTTAAAAA?GACCTTGTCG?TGAGCTAACA?TGAGCTTTCT?GATTCCTTTA?ATGAAATTTT 13680

TATTCTTTAG?GCTTTCTACA?AGCGTCTGTG?AAGCAGTGAT?TAAGGAAGCT?GTACCTCCAA 13740

TGTTGCTCTG?ATACGCCTTT?AGAGAAGTTT?CTAAACGCTC?TCTTATATTT?GGTTTTTCTG 13800

GCTCGATTTT?CAGCTTCCCC?TCACAATAAA?GAACTAAAAC?TTTATCGGAT?ATTCCGCATT 13860

GCTGCTCAGC?AGTCTTTTGA?TCTAAGGGAT?TGATTTTCAT?ATAGGTTAAT?AAAAGTTCAG 13920

GGCTAGACAT?ATAAGTTTTG?AAAATCACAT?CTTCTGAGAT?GAAAAATAAC?TCATTGGCTT 13980

CAAAATTGGC?TTTCAATAAC?GCTAAATCCC?CTCTCAAAGC?AATGGCCGCT?TTTTTGATGT 14040

TTAGAGAATC?TTCTTTACCT?ATTGTATCAT?TAGCGCTAGG?GCTAGTGGTT?GAAAAAATCT 14100

CATCTAAGTT?TTTGAGCACT?TGTTGGTTGG?TCTCTTTGTA?GGTGCTATCA?AGTTGCTTTA 14160

AACCGCTTGT?TATATCTTCT?GCCATCAAAA?CAGACAATAG?CAAAAAAGAA?TATATGGTAT 14220

TTTTCACGAG?TGTTTTCATT?TGACAATAAC?TTTAGAGCTA?GCAATGTTTC?TTGCTGTCGT 14280

TTCTCTCTCT?AATTTCAGTT?GTTCTTCCCA?AAGGTCGGCT?TTTTTTTCAA?GATTCTCTAT 14340

ATAGTTTAAA?TGATTTTCTG?CGTTTAAGAT?AGCAACTTCT?ATGAGCGCAT?TCAAATCTAC 14400

TGATCCTTTT?AAGGTTTTGA?TTTCTTCATT?GATCCCATTC?AAATAAGCGA?TATTTTGAAA 14460

ATCTGCATCA?TTTAGTTTAT?TTTGAATAAG?GGCTACAATC?TTTCTGTAAT?TCTGAATAAC 14520

CTGTTCCATA?AGGCATGCTG?AAATTTTTAG?CCCATCAAGA?TAGGGGCATT?TTGTGGGTGC 14580

TAGAGTAAAT?GTTTCAATGA?TTCCAAATGG?TGCACCCATG?CTTGAAAAAA?AACTAAGAGC 14640

AGGCTCGTAG?ATGGTGCTTT?GAAACAAAGC?CTGGCCTGTT?AGGGAATTGT?AGTCAATAAG 14700

GGTCGCTTTT?TGCATAGCCA?CTTTCAACCA?TGTTTCAAAA?CCTTTTAAGG?TTTCTTCAAA 14760

CGCCTTGATA?CCAATCGTAT?TGTAAGCGAT?GTATTTAGCG?TTGTCAGAAG?AACTTCCTAG 14820

AGCTTGAGAA?AGCATTTCCA?TTTGTGTTTT?TAGGGTAACG?CTCGGTTCAA?AGCTGTTTTT 14880

TAACGCTTCT?AAGAGAGCGT?TTTGCTGGTT?CATTTTGAGC?TTGATCATTT?CGTTATTTTT 14940

TTGGAGCGCA?ATTTGCATGT?TTTGGATTTC?TGTTTGGGTA?TTAATTTTTT?GTTTTTCCAC 15000

GATCATGTTG?ACATTTCCTC?CCAATGCGCT?AAGTGCGCTT?GAATACCCTT?CCATGACGCC 15060

AAGCAAGATG?TCTGAACCTG?CAAAAAACCC?CCCTGTCATG?CTATTGACAC?CATTAATAAC 15120

GCCATTAGCC?CCTTTTAACA?TAGCGCTTAT?AGTTGCAAGC?TGAGTTCTCA?ATTGTCCCTC 15180

TATTTGTGCT?TGAATGGCTT?TTTCTTTGGC?ACTAGATTGA?GCCTCTATGG?CTTTTAATTC 15240

GGCCTGAGCG?GTTTTTTGTT?TGGCTTGTGC?ATCCGCCTGA?ATGGCTTTTA?AGGCAGATTC 15300

AAGCGTTATT?ACTGCCCCTG?CACCATTCAG?AAACAAACCA?CAAAAAGTTA?AGAAAGAAAA 15360

TATGCTTAAA?AAACATTTCA?CATCTCTTTC?CTCACTTCAC?GATTATTTTA?GTTTGCACCC 15420

TTTCTGTTAA?GTAGCTATCT?TTTTGCCCCT?TAAGTTTGTT?TTTGATGTAA?TCAAGATAAG 15480

TCAAATGCGA?TTTCAAAAAA?GATTTATTCG?CTACTATATT?GTAATTATAT?AGCGAGCTTA 15540

TGTTAGAAAT?CGCTTGAGTG?TCATAGGTGC?TAGTAGCTAA?TCCTGATTGA?TTAAGTATCA 15600

TTTGAGAAGC?GTTCTGTAAC?AAATTGGTGT?TGTTTTTCAC?AAACTCTATA?TAGTATTCTC 15660

TCAAAATTTC?TGCTACTTTT?TCAGCATAGC?AATAAACGGC?AAGAACTTTG?TCCCCAATAG 15720

GGCATGCAGG?AGTGGTCATA?GGATTAACGC?CTGAAGTTAG?GGCATTAGCG?GCTAACGCTT 15780

GGTATTTGGC?ATAAACAGTG?GGCATAGAGA?CACTCATAGG?AGTCATAGAA?ATTTGCATGC 15840

AACTAAAAAA?CACTTTTGAT?GAGCTAGCAA?GCGCGCCTAA?AGCGGTACAG?CTATCAAGGG 15900

AATCGGCTGT?ATCATTCATT?GAGCTGTTGC?TTGCTTGAGA?ACGCAGTTGT?TCTTGTAGGG 15960

CTAGGGCGTA?TTTTGGTGCT?GCACTTGTAA?TATTGCCTAA?GATACCGCTC?ATTATTTCAA 16020

CCGTTGTTGG?CACACTAGGA?ACAGCGATTT?GATTCGTCGC?ATAAGCTTCA?ATAGCACTAG 16080

GATTTTTAGG?GGTCGTGTTA?CTCGCTAAAA?TGCTTGCAAT?CTGACTATTA?ACAGCACCAA 16140

TTTGCGCACC?TTGCGTGTTG?CCTTGCGCGT?TAAATTCCCC?TGTTAATTTG?CTGATATTTA 16200

AGATATTGTT?CCCCACAGCC?ATGCTTTGAT?CGTTAAAACC?TTGATACAAT?TGGTTGTATT 16260

GTTGGTTAGC?GGCTTTCATA?GGCATGCTTA?CGGCTTCAGC?GATGCTTTGA?TTGTATTGGG 16320

TCATGATAGC?GGTCATTTGC?GGATTCGTAA?ATCCCACAAC?AATAGGAATA?ATCGCTGCTG 16380

ACATAGCACC?CGCTACTATT?CCTGCAAATG?GCCCTGCAAC?ACCACTCGTG?CTTGAGATGA 16440

TTGAGGAAAT?TTCCGATAAG?AAGCCTGCAG?AAGATGATTC?ATATATAGCT?TGTGTGCCTG 16500

CCATGTTAAA?ACCCCCCTAA?TGGTGGTAAA?AACGATGAAT?CTGGGTATGT?TGGTGCATAA 16560

CCATACATGA?AAGGATTGTT?TGGGCCGTAA?TCGCCCATCA?TTTGGCTCAT?GAGAAGATTT 16620

TGAATGCCCC?ACATCGCATT?GATACCTAGA?TTATCATTAG?GTTGAAAACT?CCCTAAACTT 16680

ATGTTATCAA?ACTTGATATT?AACATTCTTA?TCATTATAAT?CATTGAGTAT?GGCCACTTTT 16740

TGCTCTAGGG?TTTCTTTAGG?GATCTCTATT?TTTAGTTGAT?CTCTAGAAAC?AAGCCCCACG 16800

CTATTTAGTG?CCATATCTTC?AGGACTAATA?TCTTTTATTT?CAGTGTTTTG?GTCAGCGTTA 16860

AGCGGAGCGT?TAAACATGCC?AATGATGAGA?CACCAAGCAA?ATAATAATTT?AATTTTATAA 16920

AAATTCGTTT?TCATACTTTT?GACTCCTTTA?TTCTTATTTT?TAGCACTATT?CTAGCGCATT 16980

AACACCGCTC?AATCGCTATT?TTTATTTTGA?TTTTTTTGAT?CGAGCATTTT?GTTTGTTACT 17040

TCATCAATGT?TTTGAAAATA?TTTTTCAAAA?AGCTCTTTCT?TTTTAGCTTC?AACGCTCATA 17100

TCAACCTGAA?TCCAATTAGG?AACAATAGAG?TCCATGATTA?AATGCGTGAA?GTCATAGGCA 17160

TGATTGGTTG?GGTATATTTT?GTTTTGAACA?TAGTATTCTA?AAAAATTCGC?TTGAACAAAA 17220

AAATTCTCTA?TATCGCTCTG?CATATCCTCG?CTTATGTTGT?TATTGATAGG?TTTTTCTAAT 17280

AATCTGAGAA?TCCTATACGA?CTGCATGATA?GTTTCTAGCA?TGAAGTAAAC?ATAAACATAA 17340

ACTAATGAGA?CAAAAGAATT?ATTTGCTTTA?AACGAGCTTG?CGTCATTTTT?CCCACTTTGA 17400

AGAGGAATTA?ATCTTGATAG?TGTTTTTTGG?GGATCTTGCC?CATCGTTTAT?TTCTTTAAAA 17460

AAGCGGAAGT?CTAAATCCTG?ATTATTGAGA?AATGACTTGA?CAAAGTGAAG?ATTAGCATTG 17520

AGACTATCTA?TGAGACCTGA?ATAAAGGTGT?TCTGTTTTGA?CATCATCTAT?ATTTAAAACA 17580

TTCTCATAAA?ACACATTGAC?ATGGTCTTCT?AAGAAATTAG?AAAAATCATA?AAGAGTGGTA 17640

AGGTTTTGTT?CAGTGATTTC?GCCTTCCATT?TCTTCTTCTA?TGAAGTCCAA?TTCTTCTCTC 17700

AGTTCAAAAA?GATAATTAGA?AAAACTATCC?AAAATCGTCA?AGACATCATT?TTCTAAAATT 17760

TTCAATAATT?TTTGTTCACG?CAAACTTTGT?TTCATTTTAA?TACTCCTTTA?TTTGTTGATA 17820

CATCTGCCTC?AAGGCCTGAT?ATTTATCTAT?GATACTATGG?TTTTGGATAA?TCTTGTCAAT 17880

TTCTTTGACA?AATACAGTAT?CTGTGGATAA?AATTTTCAAA?TATTCTTTAG?GAATGCCTCT 17940

CAAATTAAAA?CTAGCGATAA?CGCTAGGGCT?TCCATCTTGT?TTGTAGAGAA?TTTTCCTATC 18000

TAACCCCTTA?GTGATGATTT?CAAATTCTTT?TTCTGTAACA?TTAGCCAATC?TTTGGTAATC 18060

AGAAAGATTT?CCCCCATCGT?TTCTCAAAAA?AATCTTTGTA?GGGCATTGTT?CTCTAATAGT 18120

ATCAGCAATA?GGGCAAGCCA?AAAGATCAGT?GATGCTTTGA?GTTGCAAGTC?TAACAATAGC 18180

GTTTCTTTTC?CTTGCAGTTT?TTAGCATGTC?TCTTACAAAA?TAAGCGACCT?TTGGATCGCC 18240

TAAATATTTC?CAAGCTTCAT?CAATATCTAA?AACAAATCTA?CGCCCATCCA?TTGCCTCTTG 18300

AATACGAGCG?AAAAGGTAAA?AACAAATAAA?GGGCGAAACA?TCATTATTGT?CTAGGAAACT 18360

TGACCCATCA?ACGCCAATAA?TCGTTTTTGA?AAAATCTAAG?CGATCGGTTG?CTTTATTATC 18420

AAAAAGCCAT?TGAAATTCAC?CATTGGTTGA?TTTGCAAAAA?GGCGCTAATC?GCGCAACAAG 18480

CCCATTAGGA?TCATTGTGGT?CTTTTCCGAA?AGCATTAATC?AGTTGAGTGA?TAGGATAATC 18540

TAGGTTCATA?TCTCCTGTGA?TAAGGTTGGT?TACTGCCGCT?GCAAGCGTAT?TAGAATCGGC 18600

TAGACTAAAA?GAGATGCTGT?TGCCATTTTC?ATCTTTTTCA?TCGCTTTTGG?TTGCTAAGTT 18660

TTTCACAAGT?TCTTTGACAA?CAGAAATAGC?TGTTTGTTTT?TGCTCCATTG?TTGCATTGGA 18720

TTTTTGCACA?CAAGCCGCCC?AAGCAAAAGG?ATTTAATCCT?GTATCTGTCC?CTAGCTCAAT 18780

CTTGACATAC?TCCCCACCCA?TTGCGACAAT?ATTCCCATAA?GCGCCATAAT?CTTTATCCAT 18840

ATAGACCATA?GTGAGCTTTT?GTCTGTCTTT?GCTGACATTA?GCAGGAAAAT?TGTGAGCAAA 18900

TTGTCCCATA?GCGTTTAGAG?TCATTGACAT?AAACACCGTC?TTACCTGAAC?CGGTTGAGCC 18960

AAGTATCAAA?GTGTGTCCTG?CTGAAGCTGA?ACCAAAATCA?GTGGGCATGT?GGAAGTTCAG 19020

ATAAAAAGGC?GAATTGATCT?CGCTTTTTAG?CGTCATCACA?CTATTGCCCC?AAGCGTTATT 19080

CTCTTGATTG?CCATCAAAAC?TCATAGCCCT?CATCGCAATA?AAATCAGCAA?AATTATTAGA 19140

AGTTACATCA?AAAATAAAAG?GAAGCGTGAT?AAAAGAGCAA?TGTTTGGCAA?AAAAGTAATT 19200

TTCCATAGAG?AAAGTCGCTG?CGTTGGCTAA?AAAACCTTTA?GCGTTAAGAC?TAGAGACGCA 19260

TTCCTTGACG?CTTTGTTTCA?TTTTTTCAAA?GCTATCAGCA?AACAACACTA?AAGAATTACC 19320

ATAACTGCCT?AGCGTAATAT?CACCATTACC?CACTAATTCG?CTCAAGCAAC?CTAAAGTCAT 19380

GCCCTGCTCT?TTAGAGCCTC?CACTAATAAT?AATTCTTCTA?GAGGTGAAAG?CCAGCTTGTC 19440

CTTTAAAACC?TGTGAGTTTT?TAGGCGAATA?AGCATGCATA?AAGATAAATT?CGCTGTCTAG 19500

AGCGTTGATC?TTGTCAAACA?AATCGCTCTG?TGATTTAGGG?GCGTATTCAC?TAATCTCAAT 19560

AGCGCTAAAA?TATTTTTCAC?TCAAATCGTC?ATTTAAGATT?TTTCCATGCT?TGTTGGCAAA 19620

ATAAACTTCT?TTCACCCCAC?CATGCATTTT?TTCCTTGAGA?TACAAGTCTT?TTCTGTTGCA 19680

AATAAAAGGG?GCTTCATTCA?TTCCTACAAG?AAAATTGTAA?AACTCGCATT?GTTTGGAGTA 19740

AATAATGCCA?TCTTTGGTGT?ATTCTTTTAA?TCTAGTGGGG?TGGTATTTAC?TCAATAGCTC 19800

TTCTATGAGC?TCTATCCTAT?CCTTGAAGTT?TTCAAGCTTG?GCTCTAATAA?TCCTTTGAAA 19860

CTCTTCAAAA?TTATTGTCTG?CAAAATGCTT?TTTATTCATA?ACGGGTTCAT?TGAGAGTGTC 19920

TAATAAATCT?TGCTCTATGG?TGAGATAAAA?ACTAATATCA?TAAAAACTTT?CTCTCTTTTG 19980

CTTCTCGTTA?TAAGCTCGCA?TAAAATCATT?AGAAAAAATA?AGACCATAGT?CCCTATTGGT 20040

TTCATCAATA?ACGATTTTCT?TTTTAACAGT?GTGGAAATAA?AATTTGAATT?CAGGGGTAAC 20100

AAAATTCCTA?AAAACGCTAT?AAATAGAAGC?GTGTAACTCT?ATGAGATCTT?TTTTGGAAGT 20160

GGTTAAAAAA?TCAATGCCCC?CCAATTTGAT?TGTGCCTAAA?AGAGAATAGT?TGTTAGTAAG 20220

GATCACCCCA?TCATCTAAAA?AACATTCATA?GTTATTCGCC?AAATAGGAGT?TTGCAGCACT 20280

CACAAGTCTG?TCTTCTCTGT?TTGGATTTAA?GTGGATGTCA?TTAGCCATTT?CTTTACTAGG 20340

CTTCATGGAA?AAAATGCTCA?TGAACGCTTT?GTTTTTCACG?CCCTTAAACA?AAAAAGGTTT 20400

TTTAAATTTC?ATCGCTCGCT?CCATTCTTTG?ATAAAGCCTA?TAATCTTTCT?TGAATCCAAG 20460

AGCTACAAGC?ACAATAACAA?TCGCTACAAT?CAAAACAGGT?TCATAGGCTT?GAAAAAGAAT 20520

AACAGATAAT?ACAATTGTTA?CAAACAATAT?AAATATAGAG?GAATAAATAA?AAGTTTCAGG 20580

GAAACCAAAC?AACCTATTCC?CCCCATCAAA?CAAGACTTTA?AAAAAGGGAT?TGACACCTTT 20640

TTGCATGTCT?GCTTTAAGTT?CTTCTATTTT?TTGAAACTGC?CGCTTTTGAA?CCTCTTGCTC 20700

TATGATTAGC?TTTTTTTGTT?CATCAGCTTG?CTTGCTTGCC?ACAAACACCC?CTCTCTTTAT 20760

AGATATATCG?CTTCACATGT?AATCGTATAA?AAGATTTTTT?TGAGAGACTC?TATAGCGCTA 20820

ATATGTTTCA?AAAGATCATT?AGGGTCATAA?GAATTGAATA?CGGCCAATAA?AACATTATAC 20880

AGCTTATCAT?CGCATAGAAT?TTCTCTTGTT?TCTCCGTGCA?ATGATAGGAA?GCAGCGTTGT 20940

TTGTTGGTCG?TGCTGATGCT?TTTGAAAGTG?AAAAAGTCTT?TCACTTCAGG?ATTGATCTGC 21000

AATTCCACAT?TCAACCCCAT?TTCTTTACCC?TTTTCATCAA?AGATTTTTTC?AATAATTGGA 21060

TCGTAATGCT?TCAAATCCTT?TATTTTTTTA?AGGACTCTAT?TGACAATCAC?GAAATCAAAA 21120

ACTTCATTTT?TGATAATATC?GGGATTGACT?TCTTTGAAAG?TTACTTTCTT?GTCTTGCAAA 21180

TTTTTGATAG?TCGCCTTGAA?ACTATCAAAA?TCTAAATTCG?TATAAACACG?CCCACTAGGA 21240

GTGTTTTTTT?CTTTTTCTAG?TGCTTCTTTT?TTCGCTTGAT?TATCATCATT?TGCCAACCCA 21300

TACGAACTGA?AAACAACGAG?ACTTAAGAGA?ACTTTCAAAA?AAAAGTCTCT?TATTTTTTTA 21360

TTACTCTTAT?TGTTGATCAA?TTTAGCTAGC?TCCTCCACTT?TCGCCAATAT?TGAAGCCAAA 21420

CTTAGTGCTC?AAATAGATAA?TACCGCCTGC?CACCGCTAAC?ATAGCTATGG?GCTGCGCATA 21480

AGCAAAAACA?GTCGCCTGAC?CTCTTTTGAT?GTCATCAGAG?ATTTTCCAAA?TATCTGCTAT 21540

GCCTTTGACC?CCTAGAGCGC?AACCACCTAC?GATCGCTAAA?ACAGAAATGA?TCTGAACAAC 21600

CAAACTTTTA?GTCTCAGTAA?CGCCTGTTGT?AGGACTGGTG?ACTGCCATTA?AAGGATTGGT 21660

TGTTACCGCT?AGCCCTAAAG?TTACTACAAC?TTTCTTGTAG?CTGTCAGTGA?TTTTTGTAAG 21720

AAATTTCATG?CGTTTCCTTT?CAGATTGAAA?TAATGGTGTG?ATTATACCAA?AAAAAAATAT 21780

TTTTACACTT?CCACGCAAGC?ACCATTAGAT?TAACTGGTCT?TGTGTGTATC?CTTCTTGATT 21840

GAGATAAAAA?CCGACACTTT?TGTTTGACAA?TTGGCACAAT?TTAGAACAAT?AAACCTACTT 21900

GTCCCAACCT?TTTTTGCTTC?TCAAGTCGTT?GTAGAATTGT?AGATCTTTAG?GATCTTTGAT 21960

GTATTTTTTA?ATAATCTCAG?GTTGGAACCT?AAAAACAAGC?AAAAACAAAC?CCAAGCTGAT 22020

CAGAGTGAGA?ATAAAGCTCC?ATTTTAAGCA?ACTCCATAGA?CCACTAAAGA?AACTTTTTTT 22080

GAAGCTGTCT?TTGAAAATCT?GTCCTATTGA?TTTATTTTCC?ATGTGGATCA?CAAACACTTC 22140

TTGTTAAAAT?TTGTCTATTT?TAGCAAGTTT?TTGTTAATTG?CGGGTAAAAA?AAATATGAAT 22200

CGTTCCTAGC?CTTTAGACGC?TTGCAACGAT?TGGAATTTTT?CAATATTAAA?TAACATTAAT 22260

GAAAAAATGC?CTAATATTGT?GATATAATGA?GAGCGTTCAA?AGATATCAAT?TGACCACTCA 22320

AGCGTGTGGT?GGTTTTTAGC?AGTCTTTGAC?CAAATTTAGG?TATAGTAAGG?AGAAACAATG 22380

ACTAACGAAA?CCATCGATCA?AACAACAACA?CCAGATCAAA?CACCAAACCA?AACGGATTTT 22440

GTTCCGCAAC?GATTTATCAA?TAATCTTCAA?GTAGCTTTTA?TTAAAGTTGA?TAACGCTGTC 22500

GCTTCATTTG?ATCCTGATCA?AAAACCAATC?GTTGATAAGA?ATGATAGGGA?TAACAGGCAA 22560

GCTTTTGAGA?AAATCTCGCA?ACTAAGGGAA?GAATACGCCA?ATAAAGCGAT?CAAAAATCCT 22620

GCCAAAAAGA?ATCAGTATTT?TTCAGACTTT?ATCAATAAGA?GCAATGATTT?GATCAACAAA 22680

GACAATCTCA?TTGCTGTAGA?TTCTTCCGTA?GAGAGCTTTA?AGAAATTTGG?GGATCAGCGT 22740

TACCAAATTT?TTACGAGTTG?GGTGTCCCTT?CAAAAAGATC?CGTCTAAAAT?CAACACCCAA 22800

CAAATCCGAA?ATTTTATGGA?AAATGTTATA?CAACCCCCTA?TCTCTGATGA?TAAGGAAAAA 22860

GCAGAGTTTT?TGAGGTCTGC?CAAACAATCT?TTTGCAGGAA?TTATCATAGG?GAACCAAATC 22920

CGATCGGATG?AAAAGTTCAT?GGGCGTGTTT?GATGAATCTT?TGAAAGAAAG?GCAAGAAGCA 22980

GAAAAAAATG?CAGAGCCTAG?TGGTGGGGAT?TGGCTTGATA?TTTTTTTATC?ATTTGTATTT 23040

AACAAAAAAC?AATCTTCCGA?TCTCAAAGAA?ACGCTCAATC?AAGAGCCAAG?GTCTGATTTT 23100

GAACAAAATT?TAGCCACTAC?CACCACCGAC?ATACAAGGCT?TACCGCCTGA?AGCTAGAGAT 23160

TTGCTTGATG?AAAGGGGTAA?TTTTTTTAAA?TTCACTCTTG?GTGATGTGGA?GATGTTGGAT 23220

GTTGAGGGAG?TCGCTGACAA?GGATCCCAAT?TACAAGTTCA?ATCAATTATT?GATCCACAAT 23280

AACGCTTTAT?CTTCTGTGCT?AATGGGGGGT?CATAGCAGCA?TAGAACCTGA?AAAAGTTTCA 23340

TTATTGTATG?GGGATAATGG?TGGTCCTGAA?GCTAGGCATG?ATTGGAACGC?CACCGTTGGT 23400

TATAAAAACC?AACAAGGCAG?TAATGTGGCC?ACACTCATTA?ATGCGCATCT?TAATAACGGC 23460

AGTGGGTTAA?TCATAGCGGG?TAATGAGGAT?GGGATTAAAA?ACCCTAGCTT?CTATCTCTAT 23520

AAAGAAGATC?AACTCACAGG?TTTGAAACGA?GCGTTGAGTC?AAGAAGAGAT?CCAAAACAAA 23580

GTGGATTTCA?TGGAATTTCT?CGCACGAAAC?AACGCTAAAT?TAGACAACTT?GAGCGAGAAA 23640

GAGAAAGAAA?AATTCCAAAC?TGAGATTGAA?AATTTCCAAA?AAAACCGTAA?GGCTTATTTG 23700

GATGCCCTAG?GGAATGATCA?CATTGCTTTT?GTTTCTAAAA?AAGACCCAAA?ACATTTAGCT 23760

TTGGTTACTG?AGTTTGGTAA?TGGGGAAGTG?AGCTATACTC?TCAAAGATTA?TGGGAAAAAA 23820

CAAGATAAAG?CTTTAGATGG?GGAGACAAAA?ACCACTCTTC?AAGGTAGCCT?AAAATATGAT 23880

GGCGTGATGT?TTGTCAATTA?TTCCAATTTC?AAATACACCA?ACGCCTCCAA?GAGTCCTGAT 23940

AAGGGCGTGG?GCGCTACGAA?TGGCGTTTCC?CATTTGGAAG?CAAATTTTAG?CAAGGTAGCT 24000

GTCTTTAATT?TGCCTAATTT?AAATAATCTC?GCTATCACTA?ATTATATAAG?GCGAGATTTA 24060

GAAGATAAAT?TGTTGGCTAA?AGGGTTGTCC?CCACAAGAAG?CTAATAAGCT?CATCAAAGAC 24120

TTTTTGAACA?GCAACAAAGA?AATGGTTGGA?AAAGTTTCAA?ACTTCAATAA?AGCTGTAGCT 24180

GAAGCTAAAA?ACACAGGCAA?TTATGATGAA?GTGAAAAAAG?CTCAGAAAGA?TCTTGAAAAA 24240

TCTCTAAGGA?AACGAGAGCA?TTTAGAGAAA?GAAGTAGCGA?AAAAATTAGA?GAGCAGAAAC 24300

GACAACAAAA?ATAGAATGGA?AGCAAAAGCT?CAAGCTAATA?GCCAAAAAGA?TAAGATTTTT 24360

GCGTTGATCA?ATAAAGAGGC?TAGTAAGGAA?GCAAGAGCGG?CCGCTTTCGA?TCCGAATCTT 24420

AAAGGCATTA?GGAGCGAATT?GTCTGATAAA?CTTGAAAATA?TCAACAAGAA?TTTGAAAGAC 24480

TTTGGCAAAT?CTTTTGATGA?TTTCAAAAAT?GGCAAAAATA?ATGATTTCAG?CAAGGCAGAA 24540

GAAACGCTAA?AAGCCCTTAA?AGACTCGGTG?AAAGATTTAG?GCATCAATCC?AGAATGGATT 24600

TCAAAAATTG?AAAACCTTAA?TGCAGCTTTG?AATGATTTCA?AAAATGGCAA?AAATAAGGAT 24660

TTCAGCAAGG?TAACACAAGC?AAAAAGCGAC?CTTGAAAATT?CCATTAAGGA?TGTGATCATT 24720

AATCAAAAAA?TAACGGATAA?AGTTGACAAT?CTCAATCAGG?CTGTATCAGA?GACTAAATTA 24780

ACAGGCGATT?TCAGTAAGGT?AGAGCAAGCC?CTAGCCGAAC?TCAAAAGCTT?GTCATTGGAT 24840

CAAAAAAATG?AAAGTTTCAA?TGCTGGAAAA?AATTCTGATC?TACAAAAATC?CGTTAAAAAT 24900

GGTGTGAATG?GAACCCTAGT?CGGTAATGGG?TTGTCTAAAA?CAGAAGCCGT?AACGCTTACC 24960

AAAAATTTTT?CGGACATCAG?GAAAGAATTG?AACGAGAAAT?TATTTGGAAA?TTCCAATAAC 25020

AATAATGATG?GACTCAAAAA?CAGTGCAGAG?CCCATTTACG?CTCAAGTTAA?TAAAAAGAAA 25080

ACAGGACAAG?TAGCTAGCCC?TGAAGAGCCC?ATTTACGCTC?AAGTTGCTAA?AAAGGTGAGT 25140

GCAAAAA door G ACCAACTCAA CGAAGTTACA TCAGCAATAA ATAGAAAAAT TGACCGGATT 25200

AACAAAATTG?CATCAGCAGG?TAAAGGAGTG?GGCGGTTTCA?GTGGAGCAGG?GCGATCAGCT 25260

AGCCCTGAAC?CCATTTACGC?TACAATTGAT?TTTGATGAGG?CAAATCAAGC?AGGCTTCCCT 25320

CTTAGGAGAT?ACGCTGGATT?TGATGATCTC?AGTAAAGTAG?GGCTTTCAAG?GGAACAAGAA 25380

TTGACTCGTA?GAATTGGCGA?TCTCAATCAG?GCGGTATCAG?AAGCTAAAAC?AGGTCATTTT 25440

GACAAACTAG?AACAAAAGAT?AGATGAACTC?AAAGATTCTA?CAAAAAAGAA?TGCTTTGAAG 25500

CTATACATTG?AAAGTGCGAA?ACAAGTGCCT?ACTAGTTTGC?AAGCGAAATT?GGACAATTAC 25560

GCTACTAACA?GCCACACACG?CATTAATAGC?AATGTCCAAA?ATGGAGGAAT?TAATGAGAAA 25620

GCGACCGGTA?TGCTAACGCA?AAAAAACCCT?GAGTGGCTCA?AGCTCGTGAA?TGATAAGATA 25680

GTTGCGCATA?ATGTGGGAAG?TGCTCATTTG?TCAGAGTATG?ATAAAATTGG?ATTCAACCAA 25740

AAGAATATGA?AAGATTATTC?TGATTCGTTC?AAGTTTTCCA?CCAAGTTGAA?CAATGCCGTA 25800

AAAGATATTA?AGTCTAGCTT?TGTGCAATTT?TTAACCAATA?CATTTTCTAC?AGGATCTTAC 25860

AGCTTGATGA?AAGCAAATGT?GGAACATGGA?GTCAAAAATA?CTACAAAAAG?TGGTTTCCAG 25920

AAATCTTAAA?GGATCGAGGA?ATACTAGAAA?CACCCCTTTC?TAAAGAAAGG?GGCTTCCTAA 25980

CTAAATCATT?CCATTGAATA?CTAACACGAA?AGACTTTGTT?CTTTAAAGTC?TGCAAGGACA 26040

TTTCCTACCC?CAAAAAGACT?TAACCCTTTG?ATAAAGATAT?TTGTTCGCAG?CGTTGATGTC 26100

TCTATGTTCT?TTATACCCAC?AATCAGGAAC?AAATATTGCC?TGTGATCAAT?TTGAGCTTGT 26160

GGTTGATGCT?CCCACAATGA?TAGCAAGTTT?TGCTGGTGTA?TTGTGGGGGA?AACTTTCACT 26220

AGCAATTTGC?CATTATGCTG?TTGTTTGTAG?TCTAGCAAAC?TTGTAGATAG?GTAATTCTTT 26280

TCCAAATATA?AAAACGCTTT?TCTGGATCTC?TCTAAAGCGC?TTTATAATCA?ACACAACACC 26340

CTTA 26344

<210>121

<211>11277

<212>DNA

<213>H.pylori

<400>121

GCTTAAAGGC?TCTGAAGATT?TTTGAGTTTG?TGCCAAAACC?CCTATCTTGG?CTTTGAGTAA 60

GATTGACACT?GCCACGCATA?AGCAGGTTTT?GCAAAAATTG?CAAGAGTATC?AACAATATGC 120

TTCGCAATTT?TTAGCTTTAG?TGCCTTTGAG?CGCGAAAAAA?TCTCAAAATT?TAAACGCACT 180

TTTAGAATGC?ATCAGTAAGC?ATTTAAGCCC?TAGCGCATGG?CTTTTTGAAA?AGGATTTGAT 240

GAGCGATGAA?AAAATGCGCG?ATATTTATAA?GGAAATCATT?AGGGAGAGTT?TGTTTGATTT 300

TTTGAGCGAT?GAAATCCCTT?ATGAAAGCGA?TGTGATGATT?GATAAATTTA?TAGAAGAAGA 360

ACGCATAGAC?AAGGTGTATG?CACATATTAT?CGTAGAAAAA?GAAAGCCAAA?AAAAAATCGT 420

GATAGGCAAA?AACGGGGTGA?ATATCAAACG?CATCGGGACT?AGCGCGCGAT?TGAAAATGCA 480

AGAAGTGGGC?GAAAAAAAGG?TTTTTTTAAA?CTTGCAAGTG?ATCGCTCAAA?AATCATGGAG 540

CAAGGAAGAA?AAGAGCTTGC?AAAAACTGGG?TTATATCTAT?CAAAGGAATA?GGGATTGAAA 600

AAAATATTAC?CGGCTCTGTT?AATGGGGTTT?GTGGGCTTGA?GTGCTGATGA?GCGTTTGTTA 660

GAAATTATGC?GCCTTTATCA?AAAACAAGGC?TTGGAAGTGG?TGGGTCAAAA?ATTGGATTCT 720

TATTTAGCGG?ATAAATCTTT?TTGGGCAGAA?GAGCTTCAAA?ATAAGGACAC?GGATTTTGGC 780

TATTATCAAA?ACAAGCAGTT?TTTATTTGTG?GCGGATAAAT?CCAAGCCTAG?TTTGGAGTTT 840

TATGAAATAG?ACAACAACAT?GCTTAAAAAA?ATCAACAGCT?CTAAAGCCCT?TGTAGGCTCT 900

AAAAAGGGCG?ATAAAACTTT?AGAGGGCGAT?TTGGCCACGC?CTATTGGAGT?GTATCGTATC 960

ACGCAGAAAT?TAGAACGCTT?GGATCAATAT?TATGGCGTGT?TGGCTTTTGT?AACGAATTAC 1020

CCTAATTTGT?ATGACACTTT?GAAAAAACGC?ACCGGGCATG?GCATTTGGGT?GCATGGAATG 1080

CCTTTAAATG?GCGATCGGAA?TGAATTGAAC?ACCAAGGGCT?GCATTGCGAT?TGAAAACCCG 1140

CTTTTAAGCT?CTTATGATAA?AGTGTTAAAA?GGCGAAAAAG?CGTTCCTCAT?CACCTATGAA 1200

GACAAGTTTT?TCCCCAGCAC?TAAAGAAGAA?TTGAGCATGG?TTTTAAGCTC?CCTTTTTCAA 1260

TGGAAAGAAG?CCTGGACTAG?AGGCGATTTT?GAACGCTACA?TGCGTTTTTA?TAACCCCAAT 1320

TTCACTCGCT?ATGACGGCAT?GAAATTCAAC?GCTTTTAAAG?AGTATAAAAA?AAGGGTGTTT 1380

GCGAAAAACG?AAAAAAAGAA?TATCGCTTTT?TCTTCTATTA?GCGTGATCCC?TTACCCCAAC 1440

TCCCAAAACA?AACGCTTGTT?TTATGTGGTG?TTTGACCAAG?ATTACAAAGC?CTACCAGCAA 1500

AACAAGCTCT?CTTATAGCTC?TAATTCTCAA?AAAGAACTCT?ATGTAGAGAT?TGAAAACAAC 1560

CAAGTGTCTA?TTATAATGGA?AAAATAGGGT?TTTGTTTTAA?TGAGAGCGAT?TTAAGCGGAT 1620

TTTTCTAATT?TTAAACTTGA?TTACAGATCT?GATTACAAAT?TACAGAGCTT?GCTTTTTCAT 1680

AGCCAAATTC?CACGGATTTT?TGCAAGAATT?TTTTAGCCCT?ACTTTTTTGT?TTTCTGGTGC 1740

CAAGCCCTTC?TTTGTAAGCG?ATACCAATTC?TATAAAGGAT?TTCCCCCATT?TGTTGCTTGA 1800

GTAAAATAAT?ATTGCTTGAA?ATTTCAGAAA?TATCTGCCAT?AGAAAGTGCA?TCAGGAACCT 1860

CACCGTTGCT?GTGAAGGAAA?TACTTAAAAT?CCTCAAGTTT?TTCAAATTTC?TTTCCAAATT 1920

TTTTAGGATT?TGCGCTCAAA?CCTGAAAGAT?CAATGAAACG?CGCTCCAATA?GCGATACCAA 1980

TCGTTTGCGC?AAGGTCTAGT?AATCTAAAAT?TGTTATGAAA?ATTTATGCCT?TTATTAGAAA 2040

GTATGCGAAC?CACATGCCTG?TAAGTATTGA?GCGCTTGTTT?CAAATCCTTT?TTCATCCCTA 2100

AGCCTTGCGC?TTGCATGCGT?CCTAAAATAA?GAGCGCCCCC?TAACATGCCA?CTCCCATACC 2160

TTTTGATAGC?GTTTTTTGCA?TAGAGTTGCG?CTTTTTTGTA?ATCCACTTTC?ACGCCCTTTC 2220

CCTCCAAATA?CATTTTGGCT?AAATAAACAC?TGCCAAGCCC?AATGCCGTAT?TCTTGCGCCT 2280

TTCTAAAATT?TTTAAAGGCT?TGCTTGTATT?GGCTTTTATT?AAAATTGTCT?AAACCATTTT 2340

CAAAATAATA?TGTCTTATAT?TTTTGCGTGT?ATTCATCCCA?AGTAGGATTT?ATGCTAATAT 2400

ATCCATCAGC?TATACAAAGT?GAAAACGGCA?ATAATAAACC?TAATAAAAGC?AATAAAGGCT 2460

TTAAAAAAGA?AAAAGTGGTG?CGATAAGAAT?CTTTAAACAT?GTCGGATCCT?TTTACAATTT 2520

GAGCCATTCT?TTATAGCATA?ATGGCAACAT?GGAGATGGTT?TTATATTTTT?TGCTATAATG 2580

ACATGAATTT?GTTTCATAGT?AACAAATTGA?GAATATACCA?TCTATGGAGG?TAACACTATG 2640

GCTGACACAA?TCAATACAAC?TGAAGCAACC?CATGAAGCAA?AAAAGCCAAA?CGCTTTTGTG 2700

AATTTTTTCA?AAAACAATTT?GGCTGATAAG?CGTTATGATT?CATTAGGTCT?CATTGGAGCA 2760

GGGGTTTTAT?GTTGTGTCTT?GAGCGGTGCT?ATGGGGATTG?TCGGGATAAT?CTTTGTCGCA 2820

ATAGGAATCT?TTTTGTCTTT?TTCTAATATC?AATCTAGTGA?AATTAGTTGA?AAAATTGTCC 2880

AAAAAGCAAT?CTAAAGCGGC?AACAACTGTC?AATAACGAAA?CCCAAAAATC?TCAAGCAACA 2940

AGCGTTACCA?ACGAACCAAC?TGAAGCTAAA?GAGACTAAAG?ATTGAGGCAA?AACAACGATT 3000

TTGACTAAAG?AAAGAATAAG?AGAAATTTTC?AAAAGTTTAG?GTGTTCTAGT?GGTTTATTAC 3060

TCACTGCATG?ACTCACACAA?GTGGCCTATA?AATTCTTTTT?TTAGATTTAA?GAATGGTTAT 3120

TTGCAATATG?AGTCTAGCTA?CGAGTTGATG?GGGTTGATCA?AATCCATTGG?CAAGGCTTTA 3180

AAAATGGAAA?CCAACTGAAA?AAAAGGAAAC?TAATGTTTAG?AAAACTAGCA?ACCGCTGTAT 3240

CGCTCATAGG?CTTACTAACC?TCTAACACTC?TTTATGCTAA?AGAAATAAGT?GAAGCCGATA 3300

AGGTCATTAA?GGCCACTAAA?GAAACTAAAG?AAACCAAGAA?AGAAGCTAAA?CGACTCAAAA 3360

AAGAAGCCAG?ACAGCGCCAA?CAGATCCCTG?ATCATAAGAA?ACCTCAATAT?GTTTCTGTTG 3420

ATGACACAAA?AACTCAAGCG?CTTTTTGATA?TATACGACAC?CTTGAATGTG?AATGACAAAA 3480

GCTTTGGGGA?TTGGTTTGGT?AATAGCGCTT?TGAAAGACAA?AACCTATCTC?TACGCTATGG 3540

ATCTATTGGA?TTACAACAAC?TATCTATCCA?TAGAAAACCC?CATTATCAAA?ACAAGAGCGA 3600

TGGGGACTTA?TGCGGATCTC?ATCATCATCA?CAGGCTCACT?AGAACAAGTC?AATGGGTATT 3660

ACAACATTCT?AAAAGCGCTC?AACAAACGCA?ACGCTAAGTT?TGTCTTAAAA?ATCAATGAAA 3720

ACCTGCCTTA?CGCCCAAGCG?ACTTTTTTGA?GAGTGCCAAA?AAGAAGCGAT?CCCAATGCCC 3780

ACACGCTTGA?TAAGGGAGCG?TCAATTGATG?AGAATAAGCT?TTTTGAACAA?CAAAAACGCG 3840

CGTATTTCAA?CTACGCCAAC?GATGTGATCT?GCAGACCCAA?TGATGAAGTG?TGTTCGCCCC 3900

TAAGAGATGA?AATGGTAGCT?ATGCCCACTA?GCGATAGCGC?TACTCAAAAA?CCTAATATCA 3960

TGCTCCTTAT?AGCTTGTATA?GACTAAAAGA?GACAGATAAC?GCCAATGAGG?CTCAACCATC 4020

ACCTTATGCC?ACTCAAACCG?CTCCTGAAAA?CAGCAGAGAG?AAGCTCATAG?AAGAGCTAAT 4080

CGCTAACTCC?CAACTCATAG?CCAATGAAGA?AGAGAGGGAA?AAGAAACTCT?TAGCAGAAAA 4140

AGAAAAACAA?GAGGCTGAAT?TGGCTAAATA?CAAGCTCAAA?GACCTAGAAA?ATCAAAAGAA 4200

ACTAAAAGCT?TTAGAAGCAG?AGTTGAAAAA?GAAAAATGCT?AAGAAACCTA?GAGTAGTGGA 4260

AGTGCCTATT?TCTCCTAAGA?CAAGTAATTC?TTTTGAAACA?ATGAGGGTTG?TCAAAGAAAA 4320

AGAAAACTAT?AATGGATTAT?TAGTGGATAA?AGAAACCACG?ATCAAACGAA?GCTATCAAGG 4380

GACTTTGATT?AGTGAAAATT?CTTACAGCAA?AAAAACACCT?CTCAACCCTA?ATGACTTGAG 4440

GAGCTTAGAA?GAAGAAATCA?AAAGCTACTA?TATCAAGTCT?AATGGTTTGT?GTTATGCTAA 4500

TGGCATCAGT?CTTTATGTCA?AAATCAAAAA?CGACCCCTAT?AAAGAGGGAA?TGCTGTGTGG 4560

CTATGAGAGT?ATTCAAAATC?TGCTCTCACC?TCTAAAGGAC?AAGCTCAAGT?ACGACAAGCA 4620

AAAATTACAA?AAAGCGTTAC?TGAAAGATTC?AAAGTAAGTT?AAAGTTTTGT?TTGAGAAATG 4680

GATTGGTCTC?TTTTTACTTC?TTAATTCCTT?AGCCTATCCA?TGCCAAAAAG?TAACCATTAG 4740

TTTCAAGCAG?TATGAGAATC?TTATCCATAT?TCACCAAAAA?GGTTGCGACA?ATGAAGTGGT 4800

GTGCAGAACG?CTCATCTCTA?TCGCTTTATT?GGAAAGTTCT?TTAGGGTTGA?ACAACAAGCG 4860

CGAAATTTCC?CTAAAAGACA?CTTCCTATTC?CATGTTTCAC?ATCACTTTGA?ACACCGCTAA 4920

AAAATTCTAC?CCCACCTATT?CTAAAACGCT?TCTCAAGTTC?AAATTGCTCA?ATGATGTGGA 4980

TTTTGCGATT?TCATTGGCTA?AAAGAATTCT?GAAAGACGAT?TTTGATTACT?ACTAACAAAA 5040

ATACCTTAAT?AAAAGCGTGT?ATCAATTAGT?AGAAATGGCA?GTAGGCGCTT?ACAATGGGGG 5100

AATGAAACAC?AACCCTAATG?GCGCTTATGT?GAAAAAGTTC?CGCTGTGTCT?ATTCTCAGGT 5160

GCGCTACAAC?GAGTAGAGCA?TACTAATTTT?ACAAACAATC?TTGGTGATAC?ACTTCTACTA 5220

TCTTATGAAT?TTATAATAAT?ATCATTTGCA?TCATTATCTT?TTAATTTTTC?TAAAATATAT 5280

TTCGCTTCTT?TTTGTTAAGA?TATTTTGTCT?TTTTATTTTT?TGGAATAGGC?TTTTTGCTTT 5340

CCTTATAAGG?ACATATAGCG?TAAGAATTTT?TCCAATTCAT?ACGATTTTGG?CATAGGTGCT 5400

GTAAAAATGG?ATTGATGAAT?TTTAACCTAG?CGCATGCAAA?CAATCCACTA?GAGCGATGGT 5460

TGGCAAATCA?AAGAACACAC?AAATCACAGT?TCGCTTGAAC?CCACAGGCAC?TAAAGATTTA 5520

TCATAGCTCA?ATTCGCCTCT?AGTTTTAGCG?GCTTGCAAAT?CATCATAGAA?TGTTGCTTGA 5580

TTAGGCACTT?TCCCTAATTT?GTATTTCTTG?CTCAAGCTTG?GACTTACCTT?AATAAGCTCA 5640

TCAGTGAAGA?ATGGATCATC?GTAGTAAAGC?GCCTTGTGGC?ACTTGATGGG?TTTGAGCGTG 5700

TTTTCTAGAA?TGATAAGCTC?ATCGCCCATA?GTCATCAATT?CATCAGGGGT?CATCAAAAAC 5760

CGCTCCTTGT?TGCTGATAGA?AGTATTGGTC?TTACCGGTAT?TATCATCAAT?GCTTCGGCTC 5820

ACATCTTGTC?TGGTGTATTT?CCCTAACACC?TTAGAAAGTT?TTTCAAAATG?TTCATAGTAG 5880

TTATCGTTGT?TAATCCCATA?ATACATATTC?AAAGAAAGGT?TGTCTAAAAT?AGTCTTAGCG 5940

CCATTCCTAC?CATAACCAAG?TGGGGGGTCA?TTCTCTAGTT?GCGCCTTACT?TTGAAACACA 6000

AACGCAGGGC?GCATGTTGTA?TTCTGCCATA?ATCCCTACCG?CTTTAACAAA?GGTCTCTAAA 6060

TAGCCACAAA?GCGTAAATTC?GTCCATGAGC?ATTAAACAAC?TTCTTTTGCA?TTGTGGATCA 6120

TGGATTGGCA?GAATAAGGTT?GCTATAAATC?ATCACATTGA?AAAACAGCTC?TAATATCGGC 6180

CCAACAATAG?TGCTTTCTTT?AGGATTAGCG?ATCACGCCAA?TACTCACTTC?ATCAATCCTT 6240

AAACGCCTGA?AATCAAAATC?ATTAGCACTC?GTGAAATTTC?TGATCATGGC?GTTATTGTAA 6300

GGTGCAAACG?CTGAAGTATA?GACCCCTTGA?ACAGAGCTGT?AAGTTTCTTT?AGCGCCGCCC 6360

ATTGTCTTGA?AATTATTCCA?CATGTTTCTA?GTGGCAGGAC?TAAGCACTCT?TATATTATCG 6420

CCACTCTTAT?CTTCTTCACC?TCCAAAAAAT?TCCATCAGAG?ACACGACTTT?TTCCATGTTT 6480

GTGTCTTCAT?CAATCAAGTT?GATACCGCTT?GCCATAGAAC?CTATGAAAAA?CATCGTGGGG 6540

GTTTCAGGCA?TGATAATTTT?TTTTCTTTTG?ACAAACTCAA?GCCCCTTTTT?AGTCCACATG 6600

AGATCCCTAT?AAATATTGCA?ATTGATGACA?AAAAGGTTTC?GTGCTTGATT?GCTAAAAAAA 6660

GGATCTTTTT?CATTAGGTCT?TTCAGGGAAC?ACGAGCTTTG?CCAATCCAAA?GATTTGAGTG 6720

GAAAAATCCC?CCCCACTAGC?CACCATCCCA?TGACCTTTTA?GGCGTGTGTC?AATTTGAGAG 6780

AGTATGTCTT?CAGTTAAAAC?CACATCATTA?CCAAAATCCA?CATAAGCGAA?AGGATTAAAT 6840

CGGTGTGTTT?TTAAGGAGAA?AGGTTCATAG?ATGAACACTT?TTTGGTTGAA?GCGTTTTTCT 6900

CTGATTTTTC?CGCAAGTTTC?CATAGTGTCA?GCCTTAGGGT?CAAACACAAC?GATATTTTGA 6960

GGATAATTGA?TCATATTAGG?CATGATGAAC?CCCACCCCCT?TACCGCTTCT?AGTGGGAGCA 7020

ATCAAGCCAA?TGAACGCCTG?CCCTGCATAA?GCGATAAAAT?CCCCTAAACC?ACGCCTGCCT 7080

ACAATAACTT?CTCGTTTGTC?AAAGGCGCGT?TTTTTATTAT?TGGGTGTGAT?GAGTTTAGCT 7140

TTGATCATTT?TCTCTTCGCT?CTCCCAACTC?GCGCTACCAA?AAAGATCATC?CACTTTTTTA 7200

TTCGCTCCTA?TGTCTCTAGT?CCGAGTTAAG?TATTTTAAGA?ACCACACAAA?AAAGGTAATG 7260

AATATATAAG?AGCATAAAAT?AGAACTATAT?ACGACTAAGG?ATATATTGAA?CCCATAAACT 7320

TTGAGTGAAC?TAAAACAAAG?CGCCTTAAAA?TAGTATGTAG?GAAAATCTTG?TATCGCATAG 7380

ATCCATATAT?CAAAAAGATC?ATCATCACTC?TCAGGCAATT?TATTATCATC?ATAAAAATTA 7440

CCTAAGAGAA?TCAAGAAAAA?TAGCCCTGAT?GTGATAAAAG?AATAGGATAG?TAATAGTGTC 7500

GCTTGTAACC?AAAAGCCAAA?GGTTTTAACT?CTTTCTTTCA?GCCCCTCTAT?AATGATTTCT 7560

TTAAAGTTTT?TTTTCTTTTG?AGGTTGGTTA?GCTTTATCTT?TAAAAGCTTT?TTTTTGAGCT 7620

TTTATGAATT?TGTAGAGAAA?AAATAACGCT?ATTACCCCTA?TGAAACTAAA?AATAACAGCT 7680

AACTTATAAT?CCTCTATGAA?ATATAAGGTG?TTATACAACA?AGTCTTCCAT?TGTGCCTACT 7740

ACCTATGTTT?GATATAAAAT?TCATCACACT?GTTTGTGGTG?GTTGATATGG?ACAATCATAT 7800

CAATTAAATC?TTTAAAGCCC?TCAATGAGGC?TTTCAAACTT?GATATTCCTT?GCTGCGTTAT 7860

TAGATGAACT?CATGTTGGCT?AAACGGATAA?ACGCTTCTTC?ACTGCTCCCT?GCATGTAGAG 7920

TGGTTAGCGT?GCCTTTATGA?CCGCTACAAA?GCACATTATA?AAAATCATAT?GCCTCACTGC 7980

TTCTGAGTTC?TCCTAAAATG?ATTCTATCAG?GTCGCATTCT?CAAACATGAC?TTTAAGCAAT 8040

CAGCAGAGGT?GATATTCCCA?CCAAAGAAAA?GCTGTGTGTA?GTTCTTGTGG?TGTTTGAATA 8100

CAATCTCTTC?GGTGTCTTCA?ATGGATATGA?TCCTTTCTTC?TTTGGGGATA?AACTCCATGA 8160

TGCTTTTGAT?ATAAGTCGTT?TTACCGCTTC?CTGTGCCACC?ACAAACAATC?ACATTTTTAC 8220

CAATAGCAAT?ACCATCTTTA?ATCGCACTGA?TCGCTTGTTC?TTTGTTATCT?AGTAGATTAT 8280

AAAAACCCTG?TTCTTCAAAG?AAGCTATGAG?GATAGGTTGT?TTTGCTAGGT?ATCCTTATAG 8340

ATATGGAAAT?GGTTTCATCA?TTAACTGTAA?CAGGGGAAAG?GACAATCTGC?ACCCTTTCAC 8400

CATTCGCTAA?ATTGCTGCTC?AAAATAGGAT?TTTCATAGTT?GTCTATTGTT?TTTTTCTTAA 8460

AACTTGCACA?ACACCGAGCA?AAATGCATTA?AACGAGATAG?ACTAAAGGCT?TTCTTGTCTC 8520

TCACATCAAA?TGGTTGCCAT?TCGCCATTAT?TTTTTAAAAC?CCATACAACC?TTGTTCCCAT 8580

TGTAACAAAT?CTCAGTGATA?TTTTCCATTT?TTAAAAAATC?ACCAAAAAGT?TCTTCAGTAG 8640

CATGCCTTAG?AGGATTTAAT?GCCGCTTCTT?TTAAAGCTCT?TTCTACTTCT?AGAAATTTTT 8700

TATCTTCTGC?ACTCAATCTG?TCTTCAGTCA?TGTTCTCATT?CCACATTTAA?TTTTAATTGG 8760

GTTATCAATT?TAGCTCTTTC?TAAAGAAGTG?AGATAAGTCT?TATTTTTGCT?CAAAATAATA 8820

TATTTAGTCC?CTATATCTTG?GACAATCTCA?TTGAGCTTCC?TTCCAAAATC?ATCTATCCCT 8880

AGAATCTGAA?ACGCCACGCC?CATCATATTG?CCATCTATGA?ATGGCGGTAA?ATACTCTCTT 8940

GGCAGATAAG?AAGCCACTAG?GTCTGAAATT?CTTGCTACTT?CATCACACAT?AAAATTATTG 9000

AAGTTGTCAG?AAATTTCTAC?AACAAACTCC?CCAAGCGTTA?GTTCATTTTT?GATCGTGCTT 9060

TCTGCAAAAG?TCTTTTCTTG?TTTGCAACGA?TTGTAACTGG?CTAACACAAG?GTTGTTCAAA 9120

TAGTTGTAAT?AAGCATCAAA?ACTAATAAAA?TTCTTTTGCA?TATTGATTCT?TAACTCTTGA 9180

ACTCTTCTCA?AAAAATCTTG?CGGATCGTTG?CTATCTTTTA?AAGAAGTGGC?GTAATTTTGA 9240

ATAAACTTAT?CCCTTATTTC?ATTTGCATTT?CCCATAAGAG?ATCTGTTGCT?ATCTAAGATT 9300

TTTTGTCTTT?CTGTTTCATT?GAAACCGAGT?CCCATTGATA?TTTCCTTTCA?TTGATAGTGC 9360

TTAGATTTTC?TTCCGCCACT?ACATCCTCCA?CAATACCTGT?CGTTGGTTTT?GTCTTTTATC 9420

TTGTGAAGAA?CCAAGTTTGG?TAACACAGAT?ATATTTTATC?CTTTCTTTTG?AATTAATTGC 9480

CACCTTTGGG?GCTTGTGGTG?ATTTCTTCAT?GCTCTCTAGA?CAAAGATTTA?GTGCTTTGCT 9540

TGATAATTTC?ATCTACCACA?GATTTGTTGG?TGATTTTAAC?ATCATACACG?CCACTATAAT 9600

CAATATCGTC?CATTGTGAGA?ATCTTGATAC?TATCGCCCTC?ATTATTGTAA?ATACTTGACG 9660

GGATATTCAT?CAGTTGCCCT?AGAATTTGAT?TAGACATCTG?AGCTGAACTT?TGCATACTAC 9720

CATTGATAGC?TTGACCCAAA?GCGTAATTAA?ATTCAGGTAT?CCTTTCACTT?CTACCTTTGC 9780

CAAGGCCTAT?GAGTTATCTA?GAGCTATGAT?AGGCGCAGTT?TGCAAGAAGC?TATTAACCAC 9840

GCTTGCTATC?ACAGCAAAGC?TCTATGCGCT?TCATAAAGTG?GTTATTCACA?TAGCCATCTA 9900

CCCCTGCTTC?ACCCAACATG?CCTGCTGCTT?GAGCGTTTGC?TAGAGGTATT?ATCACACCAT 9960

CAGGCGTAAT?GGCTTTAGTA?AAGACTATCA?TTAAGCGTGT?CATAATGGGT?GTGCCACCCC 10020

TTCACGCTTT?GATAATTCCC?ATACACCTTA?GTGCCTTTGT?CTAGTAAGAT?CATAGTGCCG 10080

TTCATGTTCC?ATACATCTTT?GGCTACAACC?CCACTCACTA?TACCTGTGAG?AGTGGCGTCT 10140

ACTTTAGAAG?TCAGAGTGAT?TTCAATAGGG?GTGTATTGCG?CTAAAACAAA?TGTGGGATCA 10200

CTCTTGCCTA?TAAAGGCCTG?TTTGACAGGG?CTTGTTTCAT?CTTGTGTTTC?TGTTTTGCTA 10260

TTTGTCATCA?ATGGGGTTAC?CATTTTCATC?TACACATTCC?CCACTACTTT?CTTTTTTGTT 10320

AGTAAGAGCG?AATTCAGTAA?TATTTTTGGC?AGTCTCTGCG?ACATCTTTGT?CTATCTTATT 10380

GCTTTCTACT?CTAGCTTCTG?CTGTGGATTT?TTTACTTTTT?TCTTTATCGT?CATCTTTTTT 10440

ATTGCCACCT?AAAGCCTTAG?CTAATTTAGC?TTCTAAATTC?TTATCCTTAA?TGGTTTTTTC 10500

TGTTTCGTAT?TGCTTGGTAA?TGTCAGGTTC?TATTGAAGCA?TAAATAGGAT?TATCGCTAGC 10560

TATTTTGTCC?GCATCAACAT?TAGTGGCGTT?AATAGTGGCA?ATATCACCGC?CATTTTTGAA 10620

ATCCATTGGC?AACAATGGAT?AACCTTTAGC?CGCCATGTTA?TCAAAGGTTT?TGCGGTTTCT 10680

TAGATCGCTA?TAAATCAGAT?CCACTTCATC?AGCTTGTCGT?TTAATTCCTA?GAATTAGCGC 10740

CCTTTCACTA?TCGCTCAAGC?CCTCTAAACA?TTGCTCTATG?GCTTCTTGAT?CAGTAGGGTC 10800

ATCTAAGTTA?TCCAAGCACT?CGCTTGCTTG?ATGCAATCTT?TCTGTTTTAC?TCAAATGATT 10860

TTGTTTGCCT?TGTGTCCTTT?TATTTTGGAT?TTCTTGGATC?AAATCGCTAT?AAAGGTTTTG 10920

GCATTTCCTT?TTTTCTTCAT?CGGTCCTAGC?CGTTTTCAAA?CAATCCAAGA?CAGCCTTTTC 10980

TCTAGCTTCT?TGCAGGTATT?TGAGCTTCTC?TTCATCGCTC?AAACCATCCA?AACACTTCAT 11040

AATGGCCGCT?CTGTCGTTAG?GATCGGCGTT?TTTCAAGCAA?TCTTTGATCG?CTTTATCTTT 11100

TCGTTGGAGT?TCTTTCGCTA?AAAATTTTCT?CGCTTCAGGG?GTGAGTAATT?TCTCGCACTC 11160

TTGTTTCTCT?TTTTCATTCC?TAGCTCTTGA?AACGCAGTCC?AAATAGGCCT?TAACGCTCTT 11220

GTTGGCTCTA?TGCTATAAGA?GTTTTCTCGC?TTCAGGGGTG?AGTACTTCTC?GCAAGCT 11277

<210>122

<211>24404

<212>DNA

<213>H.pylori

<400>122

GGTTTTTTCG?CTTAGGGGTG?AGTAATTTCT?CGCATTCTTG?TTTCTCAGCT?TCAGTTTTGG 60

CTTGAGATAC?GCAGTCTTTA?TAAGCTTTAA?CGCTCTCTTT?AGCTAAAATA?TCGCTTTGTA 120

AGTCTTTAGG?GAGATCTTTC?AAACACTTTT?TTCGTTCTTC?ATCAGTTTTA?GCGTTTTTCA 180

AACAATCTAG?AACCTGTTGT?TCTAACTTTT?TTTTCGCTTC?AGGCGTGAGT?AATTTCTCGC 240

ATTCTTTTTT?CTCTTTTTCA?TTCCTAGCTT?TTGATACGCA?ATCCTTGTAA?GCCTTGACGC 300

TCATATCAGC?TAGTAGTTCT?TTTTGCAAGT?CTTGGGGAAT?ATTTTTCAAG?CACTCGTTTC 360

GTTCTTCATC?GGTTTTAGCG?TTTTTCAAAC?AATCTAGTGC?TTGCTGTTTC?AATCTTTCTA 420

TAGCTTCTTT?AGACAAGCCT?TTCAAGCATT?CGTTTTTCTC?AGCTTCAGTT?TTGGCGTTTT 480

TGATACAATC?CTTATACCCT?TGAAGTTCTT?TTTGAAGCCC?TAATTCCTTA?CGGAATTTCT 540

CTCTAATCTC?AGGGTCATTT?ATGAGTTTTA?GGCACTCGTT?TCGTTCTTCA?TCGGTTTTAG 600

CGTTTTTTAA?ACAATCTAGC?GCCACTTGAA?CTTTTTGTTG?GTTCAGTAAG?CTTTTTTTCA 660

GGTTTTGATC?TTTGATTAAA?TCTAAACACT?TGATTCTTTC?TTCTTCAGTT?TTGGCATTTT 720

TGATGCAGTC?ATTATAAGCC?TCTAAAGTCT?TTTTCATTTG?ATCTTGAAGT?TTTTTGTCTT 780

TGATAAGCTT?CAAACATTCT?TCATAGTTGC?CACCATTACT?AATACATTCA?TAAAAGGCTC 840

TCAACGGGTT?TTTGTCCTCA?ATTTCTGCAA?TATTCAAATA?GTTGTATAAG?GTTCTATTGG 900

GATCGTCATT?GAAGAAAAGA?TTCTTATCGA?TCATATTGCC?TTTTTCATTC?CGTTCTTTCA 960

GCAATCGGTT?ATACTCTTGC?CTTATTTGGA?TTTCATCATT?GACATAAAGA?TTCCTGTCTT 1020

TGCTAAAACG?AGAGCTTTTA?TCTTCCAAAG?GTATGAAGTA?GTGAAAAATG?CTTCTAGAAA 1080

ATAAAATAAT?CACGATAAGA?ACAGCGACTA?CAATGCCACC?AATAATGTAT?TTCTTTTTGC 1140

TTCCTTTGAT?AATCTCTTGA?TCGTTAGAAT?CGTTAGTTAT?TTCTTCTGAC?TCGTATTCAT 1200

CAAAATTGGT?TTTAGTTTCT?GTGGGGTTGT?CAAGATGATG?ATCTGAGCTT?TCTTTGGATT 1260

CTTTTGAAGA?ATCTTCAAAG?TGATTGGCTT?CTGTTGCTTC?TTCATTGGAT?AAATCTTGGG 1320

GTGAATGTTG?TTGGGTTTTT?TTAGAAGTTT?CATCATCAAT?TAAGTCCATT?TGAGTTTCTT 1380

CTTGATACCC?ATTATTTTCT?TGATCGTCTT?CTTCGTTCGG?TTCTTGGATT?TCTTCATCTA 1440

AATTCTTTTG?CTGAGTGAAA?GGTCTTTTAT?CATCAACTAA?TTTTCTAGCT?TTTTTGAATA 1500

ACTTGTCTGC?TAGACTGCCA?TTGCTAGATT?CTGAAGTTTC?ATTATCTCCA?GAATCCATTT 1560

GAGTTTGGGT?TTCTTCTGAC?TCGTATTCAT?CAAAATTGGT?TTTAGTTTCT?GTGGGGTTGT 1620

CAAGATGATG?ATCTGAGCTT?TCTTTGGATT?CTTTTGAAGA?ATCTTCAAAG?TGATTGGCTT 1680

CTGTTGCTTC?TTCATTGGAT?AAATCTTGGG?GTGAATATTG?TTGGGTTTTT?TTAGAAGTTT 1740

CAAGTTTATC?GTTTTCTTCA?TTCATGTCTT?AACGCCTTTT?TATTTATCTC?TGACAAGAGG 1800

GAGCTTTTTA?ATCACACGCT?CCAATTCACC?ATAGTTTTTG?ATATTGTAAT?TTTTTGTCAA 1860

TGGATTTTTC?CCATAGCCTT?TATTTATTAC?TGTTACAAGG?GCCTTGTCTT?TAATGAGCTT 1920

AAACTTTTCT?GCAATTTCAT?TAACTCTATA?CCATCTCAAT?CCTGAATTGG?TCATGTTAGG 1980

ATCAATAGCA?GCATCAGTCA?TGCTTAATTT?CCCATCAGGC?TGAACCACAA?AAATAGCAGG 2040

TTGGAGAGTG?ATGTTTTTGA?AACCAAAATA?AGTGAATGTG?CCATCATCAA?AAATTTCAGA 2100

GGGCATAATA?TGCTTAGAGC?GTTTCTCAGG?CGCTTGGTAG?TAATTGTAGT?TTCTAGGCAC 2160

AGGGTTTCTT?TTTAATGCAT?TATGCACATA?TTGAGTCTCT?AGTGCCTTTG?CTTGATCTAA 2220

AATAATTTTT?TGTTTTTCTT?CTCTTATTTT?TTCTTTGTTG?ATAATCTGTT?CATTGCTCGC 2280

CATCATTACT?CTATTGATGT?AGGCTGTGGT?ATTAAGATTT?TCTTGCTTGA?TCAATTCTCT 2340

CTGCCTCTTT?GCTTCTTCTC?TCTTTTTTAA?CTCCTCTTCA?ATAACGCTAG?AGACTTCGTG 2400

TCTTTGTGGG?TATTCTAATT?TGACTGTTAG?ATACGCCGAA?GCAAAATTGT?CTTTTTGAGC 2460

TATTCTCAAA?ATGAATTGAT?ACAAGGCTTT?ATTAGTCCGC?ACAACAAGAT?TAGTTCTCCA 2520

AGCGCTATCG?CTAGGAGATA?ATTCTATGGA?GTTATCCTCA?GGGCTTTTTT?GAGACTTATC 2580

TGTCTTAATA?TTGATTTTAT?CCTTGGCTCT?TTGTTTCACT?GCCTCTTCAG?CTTGTTTTTT 2640

GTTGAGTTCT?TCAATTTGTT?TGAGCGCATT?AGCTTGAGCC?TGTTCTTGCA?TGTCCTCTAG 2700

TCGTTCCATT?TGATCTAATT?CATTTTCTCG?TTGTTGCTTG?ATAAATTCAC?TAAGATTTTT 2760

ATTATTGCTC?AAATTTTGTG?GGTTACTCAT?AGCGTTAGTG?AGATTTTCTA?AATTGGCTCT 2820

ATTTTTTGCA?CGCTCTTCCT?TTCTTTTTTC?TCTTTTATCT?TTTTGCGCTT?TTTGCGCCTG 2880

TTCTTTAGCT?TCTTTTTCTT?TTTCTAGAGC?TTTTTTTTGT?TCTTCTAATT?CTTTAGGGTC 2940

AGGCGCATCT?ACGATAAGTT?TTTTTGTTTT?TAAAAATTCT?TGATAATCTC?TTGTCATTAG 3000

GGCAAAATTC?ACTGCTTCTT?TTTCAAACAT?GAGATTACTT?TTTACCGATT?TAGGTTGAAT 3060

GAATATATGA?TTAGAATTAG?GCACAATACT?CCAACCTTTA?TTGAAACCTG?TTGTGATGTA 3120

AGAAATAGTT?TCATCTTTTT?CAAGTTGGAT?CACGGTAACA?TTGTCTAATG?AAGTCCAAAT 3180

CGTAATAGGT?TTTTCATCTC?CCAAATAAGC?AATCTTTTTA?TTCACCACTT?TCACCCTACC 3240

ACGATTAAAA?TTTTTAATGT?CAGGTGCTGC?TGCTTCTATT?ACGCTAGATA?AAAATAAATA 3300

ACCAAGACAG?AAACAGCCAA?CAATTTTTTT?AAAAAATGCC?TGTTCCATCA?ACAATTCCTC 3360

TTAAAAAATA?TTTGTAATTG?TAACACAAGA?ATAAAGTGGC?TTATCCTTTA?AACATGGATC 3420

CACCAACTCT?TCCCACCATT?AAGGCATGTC?TTTCTCTATC?CATTCTGCTA?CCATCCATAG 3480

ATACAGAGCT?GAAAATGGTA?TTAACGATCG?CATTGACACT?CTCAATAATC?GTCTCTATGA 3540

AACCTTTTAA?AATAAATAAA?GTGATCAAAC?TCGCAATAGT?TGAATCGATA?CCCAATCCCC 3600

CTTGGTTGAT?GTTTTGTATA?GCAACAGAGG?GCGTTATGGT?CAAATTAAAT?GCTAATAATG 3660

CCAAAACACC?AAAGAGCAAA?ATAGGACTAG?CTAGAACCAA?GATAAACAAA?TTATTAATAA 3720

ACCATATCAA?TATGTTTTTC?ATAGAATCTT?TGAACCAATC?TAGCACGATC?AAACACACCG 3780

CAATAGGGAA?CACAATACCG?CTAAAAGCCC?CAGCTATCAA?AGGTTTCACA?ACAACAGTGC 3840

TTATTCTCAT?AATGATAGTT?ACTTGCATAA?AAATAGCGAA?TAAAGAAATA?CCTGCCACTT 3900

GCAAGCCTTG?TAACAAACTA?GGAGCGTTGT?TGCCAACATT?AGAAAAAACA?GCTCTTACCG 3960

CAGGTAAAAT?TGAATTAACA?GTGTAATTCA?GCACTAAATC?TAAAGCCCAA?AAAAGAACTT 4020

GATTCAGCCC?AAAAGCGCCT?GCTAAACCAA?AATAAATGGA?ATAAGAAATT?TTATAAAGAT 4080

AACCAAAACC?TGCATAGGCG?ATAAAAGAGA?CCATCGCCAT?TTTGAATAAT?GTCCCCCCAA 4140

CAAATCGCAT?GTATTCAAAA?CCTATGTTAA?TCTGAATGCC?ATTTGAAATA?TCTCTCAATT 4200

TCATAAAAGA?AATAAAAACA?AAAATCCCAA?AAACAATATA?AATCAGGTAA?GAAACAAAAT 4260

CAAGATATGA?CCCTTGCCCT?ATGATAATAT?CAGGTAGATT?GACTACACCA?TATGCAGGAA 4320

GAACAGCAGC?GTCCGCTCCT?TTGACAACAG?ATTCTAGTGC?GGCAAAAGCA?AGCATGGCTG 4380

TAGTGTTGTT?TTGCAGTTTA?TTTGCAGTGA?ATTCTTTACC?AATCAGCCAA?ATTAAACCAT 4440

CAGCTGTAAT?ATTCGTAGAA?GCTTGAGCGG?TTATTGAGCT?AATTATTTGC?AAAAGAATAT 4500

TGCCTTTCAC?ATTGTCCTCA?ACACCGCCTT?TGGTAAAATT?CTGAATCTTG?TTGCTCAAAT 4560

TGTCTAGCAC?GCTATCCATG?GATACATCTA?TGTTTTTATT?TATCAATGCG?TTCCAACCAA 4620

AATTACAGCC?ACTTGATGGC?GTTAGAGCAA?AACCTTGTAT?AGCCGTAGCA?ACACTTGCCC 4680

ATGCCGATCC?CCATAAAGGA?CCTAAAGTAT?TCAAATATTT?CACCAGATTG?CTAGCGGCTA 4740

AACTTGTGGC?TAATGGTGTG?CTAAGCGCTT?CGATCACACC?CTGCCCTGAA?CTCTTTCCAC 4800

TCCCTGATGC?ACCAATAGAT?GTATAGCCTG?TCAAAATATC?TGCAAAACTT?TTGTTGGTTA 4860

AAACATAACT?CGGTATCAGC?ATGCAATAAA?CTGTTTGGTA?AATTTTGAGA?TTTGAAACAA 4920

TGGGCAAATC?AATAGCTTTC?AACCAATTAG?GAACAATGAG?AAAAAAACTC?ATGATCGTTA 4980

TTAAAAAAGT?TCTTTTAATA?TTAAACATGT?TCTTATTTAT?TTAATGCCTT?ATTTTTTGAT 5040

TCCACTTCTT?TAATCTTTCT?CAAAATTTCG?CTTACCGTCT?GTTCGTTTTG?TAAATCTGTG 5100

ATTTGAATGT?CAAACACTTT?GAAGCCAAAA?GGATTGATGA?TAAGATTTTC?TTGAGAAGAG 5160

TTACCTCTGG?CAAAATCATA?ATAAATAGTT?ACTTGTTTTT?TAGTAATATA?TTCATAATTT 5220

TCCATTGTAT?CGGGTGTGAT?TTTGATGGTA?ATGAAAAATG?TTAATCTCGT?TAAGGGACTA 5280

TTTTTGACTT?TTTCTCTTTG?TATGTTGGAG?CTAATGATAG?CTTCTGCTCG?GACTTTATCT 5340

ACAAATTGTC?TGATATTTTC?ATTGAACATT?CTCATTGCTT?GGGTTTGGAA?ACTCACATCG 5400

CAATACTGCA?TTAGTTGATC?CTTGCGATCC?CTCAAAGAAT?TTTTGCTATA?ACCAAACAGC 5460

AATGAAACAA?ATTTTGAAGT?TGCACTATCC?ACAACAGCTT?CAGAATTGAC?AATTTGCCTA 5520

GCATCGGATC?GTTTGACAAT?TTTAAATTCT?CCTGTGTATC?GATCAATGCC?ATAAACAAAT 5580

ATATCTGTTT?TCTTCAAAGG?CATCATCATC?ACAATACTTG?CTACAGCGGC?GATATTGAGT 5640

GCCATAGAGA?GATAAAAAGC?CCTTTTGAAA?GTCCTATTGG?CTTTATTGAG?TTTTGCCAAT 5700

CTATCAAGGG?CTATCACACC?CCCAACTAAA?TTTTCATCAA?TCAAGACTTC?CTCGTTTTTT 5760

TTCCCTAACA?TGCGACAGCT?TTATGGTTTA?GTTATTGGTT?TGTTGGTTGT?AAAATTTGAG 5820

AAATTTTTTC?ATTAAGAACC?CCTTAAAATA?CCTTAAATTG?TAGTATAGCA?AAATTTCTGT 5880

AAAAACTATG?TATTTAATTT?AAGGTAAGAG?CAATGAGTAA?GCAGTCGTAA?CCCAGTAATG 5940

AAATTTTAGA?AGCGCCTAAT?TCAAAGAGGT?AAGACAATCA?CAACTCAGAG?AGAGAATGGT 6000

ATAATAAGAA?AACAATTTCT?CAATTTAATT?CTTGAAAGGA?GTTTCATGAA?CGATACAACA 6060

GAGCATCATG?GATCCAATTC?GCTAAACGCC?CCATCACCTA?GCAACTCACA?GAGCAATGAT 6120

CTTTTAAATT?TGCTAGACTC?GTTATATCCC?AAAGGGAGTT?TAGGGGAGCA?AAGATTTCAC 6180

GAAGCTCTAA?AGAATCAAGA?AGAGTTGAAA?AATATCCTAA?TAGAAATAGA?AAAGCTACCG 6240

CAAGAAAAAA?GGTATGAACT?TCTGATGCAG?ATAGGGCAAG?CCAAACAGAG?AATAATGGAA 6300

GCATACGCTC?ATTCATTCTT?GGGATATATA?GGGGGACTAG?AGCATCTGTT?AGGATTATGT 6360

ATGGGTGGGA?TATTTGTTCT?GTTTGCAATC?TATTTTGTAT?TTTTAAGAAC?TAGCAAAAAC 6420

ACGGATTTGG?TGGAAAGTCT?AAAAACAAAA?CTAAAACTTC?AGTATTTTTA?CTATGCCTTT 6480

GGTGCAGGTG?CGGTTTTGTT?TTTTGGATTA?GAAACAATTA?GATCTATTTA?TGAACTATAT 6540

ATATTAGGAA?TTGGTAGCAC?TAACGATAAG?GTGCTCTTTG?TTTTGAAAAA?CATTTGCTTC 6600

ATAGGTATGG?GCTATTTGAT?TTATAAAGTT?ATTAAGGTTA?TTGGTATAAA?AAATTTTATC 6660

AATGGTCTTT?TCACTTCAAA?GAAACAAGAA?TAATAAGGAG?AAACAACAAT?GAGAATGAGA 6720

GCAAGTGTTT?TAATCGGTGC?GACAATTCTG?TGCTTAATTT?TAAGCGCATG?CAGTAATTAT 6780

GCGAAAAAAG?TGGTGAAACA?AAAGAACCAT?GTTTATACGC?CTGTGTATAA?TGAACTGATA 6840

GAGAAGTATA?GTGAGATACC?CTTAAATGAC?AAACTCAAAG?ACACACCATT?CATGGTGCAA 6900

GTGAAGTTGC?CAAATTACAA?GGACTATTTG?TTGGATAATA?AACAAGTTGT?ATTAACTTTC 6960

AAACTCGTTC?ATCATTCTAA?AAAGATTACG?CTCATAGGCG?ATGCCAATAA?GATACTTCAA 7020

TACAAGAATT?ACTTCCAAGC?TAATGGAGCA?AGATCTGATA?TTGATTTTTA?CTTGCAGCCT 7080

ACTTTGAATC?AAAAGGTGTG?GTGATGATAG?CGAGTAACTA?CAATGATAAT?CCCAACAACA 7140

AAGAACAACC?ACAGACCTTT?GATGTGTTGC?AAGGAAGTCA?GCCAATGCTA?GGAGCTAACA 7200

CAAAAAACTT?GCATGGCTAT?GATGTGAGTG?GAGCAAACAA?CAAGCAAGTG?ATCAATGAAG 7260

TGGCAAGAGA?AAAAGCTCAG?CTAGAAAAAA?TCAATCAGTA?TTACAAAACG?CTCTTACAAG 7320

ACAAGGAACA?AGAATATACC?ACTAGGAAAA?ATAACCAACG?AGAAATTTTA?GAAACATTGA 7380

GTAATCGTGC?AGGTTATCAA?ATGAGGCAGA?ATGTGATTAG?TTCTGAGATT?TTTAAGAATG 7440

GCAACTTGAA?CATGCAGGCC?AAAGAAGAAG?AAGTTAGGGA?GAAGCTGCAA?GAAGAAAGAG 7500

AGAATGAATA?CTTGCGCAAT?CAAATCAGAA?GTTTGCTCAG?TGGTAAGTGA?TTGGAAGAAA 7560

AGGAGAGAGT?AGATTTTTTT?AAGGGTAGAG?AGCAACGCCA?ATAGGCGTTA?GCCTTACTTG 7620

ATAGGTGAGG?CGATCAAGTA?GGTAATCTTT?TTAAAGCACT?CATTATTTTT?TAATTCTATC 7680

TCTGCCTAAG?ACAAATATTT?TTCAAACTGA?AGTTTGTTAG?TTACACCGAG?ATTTTTTGTT 7740

CGTTTTCCAC?ATCAAGCATT?TTGCACTCCT?TTTTCTTTCA?TGTATTTTTC?AAGATCAAAT 7800

TTCATTAGCA?AATCCCTAAC?ATAGTCGTTA?TATTGTTCAA?TGGTTTTTAG?ATTAGCATAG 7860

AAATTCACTT?CCTCATCTGT?CATCACAAAC?AATTTCAATA?GTGGGAGTTT?AGTGCCATAC 7920

AATTCTATTT?GCGAGTCCAT?TTCTCTAATA?CTCATCTTGA?ACATGATGGG?CTTACTGAAG 7980

AAAGGCAGAA?ATATTCCAAG?AATTGATCGA?TCAAATTTAG?AGAATAAGAA?ATTAGGATTC 8040

TTTGCAATCG?CATGCAACAG?CTCCATAGTC?TCACTCTCAA?GCAATCGATA?AACCTTTTTA 8100

AATTTATCAA?CACCAATGCT?TTTGATAACA?GCGCGATAAT?CTTTCATGTA?ATTTCTTAGA 8160

ACCTTATCTA?ACGCTCCCTT?GTTTGTATGC?ATCTGTTTGA?AAAAATCATG?CATGGTTTTT 8220

ATTTGATCTA?TGATTTTCTT?TTTTTCATCA?GTGTTTAAAA?GTTCGTTCTC?CTGCAAACTC 8280

TCAATAAGTT?TTTCTTTCTT?ATCTTTTGAG?TCAGCAATCA?TTGAGAAGAG?TTTTCGCATG 8340

TTATTACTCA?TATCGCTCTT?GGTCCCTTCA?ATGGATTTGG?TTTCTCTTTA?GATTGTTCAA 8400

ATCGTAAAGT?TTTATATTAA?AATTATACAA?TATCTGTTGT?GTGAAAATTT?CAGAGCGGTC 8460

ATAATTCAAA?GAGCGAGAAA?CTATTTTTTA?ACCATAAAAC?ATTTTTCAAT?CACTCTTATA 8520

TCTGTTTTTC?AAAACCTACA?AAAAACGCTT?TCACAAATAG?CTCTAAAAAC?CGATTTAAAA 8580

AAAGTTTTAA?TGCTATAAAA?AAGCAAGATA?AGTCGTAAAA?ATGCGTTACA?ACTAAATAAA 8640

GGAATAACTC?AATTTTCAAA?AAGGAGTCTT?AAGTTACCAT?TATTACGATG?TTAAACAAGT 8700

TCGTAATTAA?AATTCTCAAG?ACCAAATACA?GAGAGATTAT?TCAATATTTT?TCAATGGATA 8760

TTGAGCTTTT?CAAAATAGCA?AAAATCAATA?ATAAATCAAA?CATCAATAAG?ACTTTGTAGT 8820

ATTCTTTAAT?TTGAACAAAT?AAAATACAAA?TTTTTTAGGG?TATCGTAAAT?TTTCTAAACT 8880

TTCTTTATTT?TTAAAAACCC?ATAGCAATCT?TAATACCACT?AGCTGAACAT?TATGATTTGA 8940

TTGATGATTG?ATTGATGATT?GATTGATGAT?TGATTGATGA?TTGATTGATG?ATTGATTTTT 9000

GCTATTTTGA?AAAGATCAAT?ATCCATTGAA?AAATATTATT?ATAATCTCTT?TATTAAATGA 9060

TAGGCTTGAT?TATAGGCAAA?AGGAGTGTTG?TAATTTATTG?GATTTCATAG?AAGTATCTTA 9120

ACACTTTTTA?GTGTAAATTG?GTCTGTTGTT?AAGAGTTGTG?GGGACACTCC?AATGTTTAGC 9180

AGAATACACT?AAAAATTAAA?TGGATGAGAT?AGAACGATAC?TAAAAATAGC?CTAATGGGCT 9240

AGGCGCTTAC?ATATGGTACT?TTAAAGGACG?GAGTTTTTCG?CTAGTAAGAT?AAAGTTATCA 9300

TTAGAGCTTG?AGATACTTAC?AAGAACCAGT?TTTGCCATTG?AGTCATAAGC?ATGATTAGCT 9360

TCATTGTGAA?GTTTGCGTGG?CTTAAGAGAT?AGTATTTGCT?TATTATGCTG?AGAGAAACGA 9420

GTAGTAAAAG?ATAAGTAGTG?TAACTAAAAA?AGCTAGGTTT?TATTATAAGA?GCAAATAAGA 9480

ATAATATTGG?ATAAACTAAA?ATCACCCCTG?CCCCATAAGA?AAAAAGCCCT?ATTAAAAAAC 9540

CTATGACGAT?AGAGCTGATA?TTGAACAGCC?TATAATAAAG?GCTGTACTTA?TCTAAATGTT 9600

TGTTGAAAGA?ATGTTTGAAT?TGTAAGAAGT?TTTGTTTTAA?TTTGCTAATT?GGCTGTTTCA 9660

TTTTGGTTTT?TAAAGAAATA?GTTCAAGGCG?GTGAGCCTAT?AAAGGAGCAT?AAAATAATAA 9720

ATATTTTACA?AAACCACCCT?AATCTAACTC?CAAATCTCAA?AGAATACCCC?ACTTGCCGAT 9780

ACTAACATGT?GGTATAGCAC?AAACCAACGA?CTTGTTTGTT?TATGCCAAAC?AAAGAACAGA 9840

AAACATCTGT?TAAAGAACAA?AAGAGTTTTT?CATTTAAAAA?ATACCGACCC?ATTTTATAAA 9900

AATAATCTTA?AGAGAAACTT?AAAAAATACC?AACAAGCCGC?ATACAAGTGA?GAAAAACATA 9960

ACACTATAAG?ACCTAGATTT?TATTTACCTT?TTGGATATGG?AAAAATTTTG?ATCCATAGTT 10020

TTGTAAAAAT?TGTGGTAAAA?TGTATTGATA?TTTTTTGAAA?TTTTAAGGTT?ACAAAAACTA 10080

TAAGATGCTT?GCAAAAATCG?TTTTTGGCTC?ATTGGTTGCG?TTTGGAGTTT?TGTCGGCTAA 10140

TGTGGAGCAG?TTTGGTTCAT?TTTTCAACGA?GATAAAAAAA?GAACAAGAAG?AGGTGGCTGC 10200

AAAAGAAGAC?GCTCTCAAGG?CTAAAAAGAA?GCTCTTAAAC?AATACGCATG?ATTTCTTAGA 10260

AGACTTGATT?TTTAGAAAAC?AAAAAATCAA?AGAGCTTATG?GATCATAGAG?CTAAAGTTCT 10320

TTTAGATTTA?GAAAACAAAT?ACAAAAAAGA?AAAAGAGGCT?CTAGAGAAAG?AGACAAGGGG 10380

TAAAATCCTC?ACTGCTAAGT?CAAAGGCTTA?TGGTGATCTA?GAGCAAGCCT?TAAAAGATAA 10440

CCCTCTCTAT?AAGAAACTTC?TTCCTAACCC?TTATGCCTAT?GTTTTAAACC?AAGAAACATT 10500

CACCAAAGAA?GATAAAGAGC?GTTTGAGTTA?TTACTACCCC?CAAGTGAAAA?CGAGCAGTAT 10560

TTTTAAAAAA?ACTACCGCTA?CCACTAAAGA?TAAGGCTCAG?GCTTTGCTTC?AAATGGGTGT 10620

GTTTTCTTTA?GATGAAGAAC?AAAACAAAAA?AGCGAGCCGA?TTAGCTTTAT?CTTACAAGCA 10680

AGCGATTGAA?GAATATTCCA?ATAACATTTC?TAATTTATTG?AGCAGAAAAG?AATTGGATAA 10740

TATAGATTAT?TACTTACAGC?TTGAAAGAAA?CAAGTTTGAC?TCCAAAGCAA?AAGATATCGC 10800

TCAAAAAGCT?ACTAACACGC?TTATTTTTAA?CTCGGAACGC?TTGGCGTTTA?GCATGGCGAT 10860

TGATAAGATC?AATGAGAAAT?ACTTAAGGGG?CTATGAGGCT?TTTTCTAACT?TGTTGAAAAA 10920

TGTCAAAGAT?GATGTGGAAT?TGAATACTCT?GACTAAAAAC?TTTACCAATC?AAAAATTGAG 10980

TTTCGCTCAA?AAACAAAAAT?TATGTTTGTT?GGTTTTAGAC?AGCTTCAATT?TTGATACCCA 11040

ATCCAAAAAA?TCTATATTAA?AAAAGACTAA?TGAATACAAT?ATTTTCGTAG?ATAGCGATCC 11100

TATGATGAGC?GATAAGACAA?CTATGCAAAA?AGAACACTAC?AAGATATTTA?ATTTCTTCAA 11160

AACAGTGCTT?TCTGCATACC?GAAACAATGT?TGCCAAGAAT?AATCCCTTTG?AATAGGAAAG 11220

GAGACACTCT?TGAAAAGTAT?CTTCAAAAAA?CTAGGTTCTG?TCGCTCTTTA?TTTTTTAGTT 11280

ATTTATGGGG?GCTTAAACGC?TATCAATACA?GCATTATTAC?CGAGTGAATA?CAAAAAATTA 11340

GTGGCTTTAG?GCTTTAAAAA?AATCAAAACA?TTCCATCAAA?GACATGACCG?AAAAAGAAGT 11400

TACAGAAGAG?GAAAAAGAAT?TCGCCACTAA?AGCTTTGAGA?GAAAAATTAC?GAAATGATAG 11460

GGCGAGAGCG?GAGCAAATTC?AAAAGAATAT?TGAAGCGTTT?GAAAAAAAGA?ATAACTCTTC 11520

TATTCAAAAA?AAAGCGGCTA?AACACAAAGG?ATTACAAGAA?TTAAACGAAA?CTAACGCTAA 11580

CCCTTTGAAT?GACAACCCTA?ATAGCAATTC?TTCCACTGAA?ACCAAATCCA?ATAAAGATGA 11640

TAACTTTGAT?GAGATGATCA?ATAAGGTGAA?TGAAGCTTTT?GTGAAACCTG?CTGCTCCGCT 11700

TGTGCCTAAT?GAATGGAGAA?CACCTGAAAT?TGAAATCATT?ATCAATGAGT?GTATTATTTC 11760

AAGCAACGAT?TACGATGGGT?TAAGAAAGTG?TTTGATCAAA?GACATCAAGG?ATCAAAAAAT 11820

TCTTGCCCCC?TTATTAGAAA?AAATTCAAGA?AATAGAGACA?GAAAATAACA?AGTTTTCTAG 11880

ACAACACTTG?AGTGGTTTAA?AACTCGCTCT?TAATAACAGC?AACAATAGAA?CCTTTCTTAT 11940

AGCTTCATGC?GCTATTTGTG?AGAAGAGAAA?AAAAGAAATG?GAGCAAGAAA?ACAACCACCA 12000

AGATACTACA?AATGCAAGTG?AGTTTGGAGC?TACTGACACA?AAAGAAAATG?AAGCAAAAGA 12060

TGCAGCATTC?TCAAACAATC?GTTCTAAATC?TGAACTGCCC?AATAGCGTCA?TTAATCAAAT 12120

AGAACAAAGC?ATCGCTCATG?GAAAAAAATA?GCGATCAAAA?TTATTAGCTC?AAAAAAACAA 12180

CTAGAGAAAC?AAATCCCAAA?GGTTAGAAAT?CATGGCCTGT?CGTCTCAGAA?AAATCATTTA 12240

ACAATAACCT?TACTTGATTG?CCTTTCTTGT?AGGTATTGTC?GCTTGCTTTG?TTCTAGGGAT 12300

ATTTCTAATG?CATCCAACTT?CTCTAAATAA?TTTAAAAAGA?TCTTGTCGTG?AGCTAACATG 12360

AGCTTTCTGA?TTCCTTTGAT?GAAATTTTTA?TTCTTTAGGC?TTTCTACAAG?CGTCTGTGAA 12420

GCAGTGATTA?AGGAAGCTGT?ACCTCCAATA?TTGCTCTGAT?ACGCCTTTAG?AGAAGTTTCT 12480

AAACGCTCTC?TTATATTTGG?TTTTTCTTGC?TCGATTTTCA?GCTTCCCTTC?ACAATAAAGA 12540

ACTAAAACTT?TATCGGATAT?TCCGCATTGT?TGCTCAGCAG?TGTTTTGGTC?TAAGGGATTG 12600

ATTTTCATAT?AAGTTAATAA?AAGTTCAGGG?CTAGACATAT?AAGTTTTGAA?AATCACATCT 12660

TCTGAGATGA?AAAATAACTC?ATTCGCTTCA?AAATTGGCTT?TCAATAACGC?TAAATCTCCT 12720

CTCAAAGCAA?TGGCCGCTTT?TTTGATGTTT?AGAGCATCTT?CTTGACCTAT?TTCATTATTA 12780

GCGCTAGGGC?TAGTGGTTGA?AAAAATCTCA?TCTAGGTTTT?TGAGCACTTG?TTGGTTGGTC 12840

TCTTTGTAGG?TGCTATCAAG?TTGCTTTAAA?CCGCTTGTTA?TATCTTCTGC?TATCAAAACA 12900

GACAATAGCA?AAAAAGAAGA?TATGGTATTT?TTCACGAGTG?TTTTCATTTG?ACAATAACTT 12960

TAGAGCTAGC?AATGTTTCTT?GCTGTCGTTT?CTCTCTCTAA?TTTCAGTTGT?TCTTCCCAAA 13020

GGTCGGCTTT?TTTTTCAAGA?TTCTCTATAT?AGTTTAAATG?ATTTTCTGCG?TTTAAGATAG 13080

CAACTTCTAT?GAGCGCATTC?AAATCTACTG?ATCCTTTTAA?GGTTTTGATT?TCTTCATTGA 13140

TCCCATTCAA?ATAAGCGATA?TTTTGAAAAT?CTGCATCATT?TAGTTTATTT?TGAATAAGGG 13200

CTACAATCTT?TCTGTAATTC?TGAATAACCT?GTTCCATAAG?GCATGCTGAA?ATTTTTAGCC 13260

CATCAAGATA?GGGGCATTTT?GTGGGTGCTA?GAGTAAATGT?TTCAACGATT?CCAAATGGTG 13320

CACCCATGCT?TGAAAAAAAA?CTAAGAGCAG?GCGCGTAGAT?GGTGCTTTGA?AACAAATCCT 13380

GACCTGTTAG?GGAATTGTAG?TCAATAAGGG?TCGCTTTTTG?CATAGCCGCT?TTCAACCATG 13440

TTTCAAAACC?TTTTAAGGTT?TCTTCAAACG?CCTTGATACC?AATCGTATTG?TAAGCGATGT 13500

ATTTAGCGTT?GTCAGAAGAA?CTTCCTAGAG?CTTGAGAAAG?CATTTCCATT?TGTGTTTTTA 13560

GGGTAACGCT?CGGTTCAAAG?CTGTTTTTTA?ACGCTTCTAA?GAGAGCGTTT?TGCTGGTTCA 13620

TTTTGAGCTT?GATTATTTCG?TTATTTTTTT?GGAGCGCGAT?TTGCATGTTT?TGGATTTCTG 13680

TTTGGGTATT?AATTTTTTGT?TTTTCCACGA?TCATGTTGAC?ATTCCCTCCC?AATGCGCTAA 13740

GCGCGCTTGA?ATACCCTTCC?ATGATGCCAA?GCAAGATGTC?TGAACCTGCA?AAAAACCCCC 13800

CTGTCATGCT?ATTGACACCA?TTAATAACGC?CATTAGCCCC?TTTTAACATA?GCACTTATAG 13860

TTGCAAGCTG?AGTTCTCAAT?TGTCCCTCTA?TTTGCGCTTG?AATGGCTTTT?TCTTTGGCAC 13920

TAGATTGAGC?CTCTATGGCT?TTTAATTCGG?CTTGAGCGGT?TTTTTGTTTG?GCTTGTGCAT 13980

CCGCCTGAAT?GGCTTTTAAG?GCAGATTCAA?GCGTTATTAC?TGCCCCTGCA?CCATTCAGAA 14040

ACAAACCACA?AAAAGTTAAG?AAAGAAAATA?TGCTTAAAAA?ACATTTCACA?TCTCTTTCCT 14100

CACTTCACGA?TTATTTTAGT?TTGCACCCTT?TCTGTTAAGT?AGCTATCTTT?TTGCCCCTTA 14160

AGTTTATCTT?TGATGTAATC?AAGATAAGTC?AAATGCGATT?TCAAAAAAGA?TTTATTCGCT 14220

ACTATATTGT?AATTATATAG?CGAGCTTATG?TTAGAAATCG?CTTGAGTGTC?ATAGGTGCTA 14280

GTAGCTAATC?CTGATTGATT?AAGTATCATT?TGAGAAGCGT?TTTGCAACAA?ATTGGTATTG 14340

TTTTTCACAA?ATTCTATATA?GTATTCTCTC?AAAATTTCTG?CTACTTTTTC?AGCATAGCAA 14400

TAAACGGCAA?GAACTTTGTC?CCCAATAGGG?CATGCAGGAG?TGGTCATAGG?ATTAACGCCT 14460

GAAGTTAGGG?CATTAGTGGC?CAGTGCTTGG?TATTTGGCAT?AAACAGTGGG?CATAGAGACA 14520

CTCATAGGAG?TCATAGAAAT?TTGCATGCAA?CTAAAAAACA?CTTTTGATGA?GCCAACAAGT 14580

GCACCTAAAG?CGGTACAGCT?ATCAAGGGAA?TCGGCTGTAT?CATTCATTGA?GCTGTTGCTT 14640

GCTTGAGAAC?GCAGTTGCTC?TTGTAGAGCT?AGGGCGTATT?TTGGTGCTGC?ACTTGTAATA 14700

TTGCCTAAGA?TACCGCTCAT?CATTTCAACC?GTTGTTGGCA?CACTAGGAAC?AGCGATTTGA 14760

TTCGTCGCAT?AAGCTTCAAT?AGCACTAGGA?TTTTTAGGGG?TCGTGTTACT?CGCTAAAATG 14820

CTTGCAATCT?GACTATTAAC?AGCACTAATT?TGCGCGCCTT?GCGTGTTGCC?TTGCGCGTTA 14880

AATTCCCCTG?TTAATTTGCT?GATATTTAAG?ATATTGTTCC?CCACAGCCAT?GCTTTGATCG 14940

TTAAAACCTT?GATACAATTG?GTTGTATTGT?TGGTTAGCGG?CTTTCATAGG?CATGCTTACG 15000

GCTTCAGCGA?TGCTTTGATT?GTATTGGGTC?ATGATAGCGG?TCATTTGCGG?ATTCGTAAAT 15060

CCCACAACAA?TAGGAATAAT?CGCTGCTGAC?ATAGCACCCG?CTACTATTCC?TGCAAATGGC 15120

CCTGCGACAC?CACTCGTGCT?TGAGATGATT?GAGGAAATTT?CCGATAAGAA?GCCTGCAGAA 15180

GATGATTCAT?ATATAGCTTG?TGTGCCTGCC?ATGTTAAAAC?CCCCCTAAGC?TTGGTGGTAA 15240

AAACGATGAA?TCTGGATATG?TTGGTGCATA?ACCATACATG?AAAGGATTGT?TTGGGCCGTA 15300

ATCGCCCATC?ATTTGGCTCA?TGAGAAGATT?TTGAATGCCC?CACATCGCAT?TGATACCTAG 15360

ATTATCATTA?GGTTGAAAAC?TCCCTAAACT?TATGTTGTCA?AACTTGATAT?TAACATTCTT 15420

ATCATTATAG?TCATTGAGTA?TGGCCACTTT?TTGCTCTAGG?GTTTCTTTAG?GGATCTCTAT 15480

TTTTAGTTGA?TCTCTAGAAA?CAAGCCCCAC?GCTATTTAGC?GCCATATCTT?CAGGACTAAT 15540

ATCTTTTATA?TCAGTGTTTT?GGTCAGCGTT?AAGCGGAGCG?TTAAACATGC?CAATGATAAG 15600

ACACCAAGCA?AATAGTAATT?TAATTTTATA?AAAATTCGTT?TTCATACTTT?TGACTCCTTT 15660

ATTCTTATTT?TTAGCACTAT?TCTAGCGCAT?TAACACCACT?CAATCGCTGT?TTTTGTTTTG 15720

ATTTTTTTGA?TCGAGCATTT?TGTTTGTTAC?TTCATCAATG?TTTTGAAAAT?ATTTTTCAAA 15780

AAGCTCTTTC?TTTTTAGCTT?CAACGCTCAT?ATCAACCTGA?ATCCAATTAG?GAACAATGGA 15840

GTCCATGATT?AAATGCGTGA?AGTCATAGGC?ATGATTGGTT?GGGTATATTT?TGTTTTGAAC 15900

ATAGTATTCT?AAAAAATTCG?CTTGAACAAA?AAAATTCTCT?ATATCGCTCT?GCATATCCTC 15960

GCTTATGTTG?TTATTGATAG?GTTTTTCTAG?TAATCTGAGA?ATCCTATACG?ACTGCATGAT 16020

AGTTTCTAGC?ATGAAGTAAA?CATAAACATA?AACTAATGAG?ACAAAAGAAT?TATTTGCTTT 16080

AAACGAGCTT?GCGTCATTTT?TCCCACTTTG?AAGAGGAATT?AATCTTGATA?GTGTTTTTTG 16140

GGGATCTTGC?CCATCGTTTA?TTTCTTTAAA?AAAGCGGAAG?TCTAAATCCT?GATTATTGAG 16200

AAATGACTTG?ACAAAGTGAA?GATTAGCATT?GAGACTATCT?ATGAGACCTG?AATAAAGGTG 16260

TTCTGTTTTG?ACATCATCTA?TATTTAAAAC?ATTCTCATAA?AACACATTGA?CATGGTCTTC 16320

TAAGAAATTA?GAAAAATCAT?AAAGAGCGGT?AAGGTTTTGT?TCAGTGATTT?CGCCTTCCAT 16380

TTCTTCTTCT?ATGAAGTCCA?ATTCTTCTCT?CAGTTCAAAA?AGATAATTAG?AAAAACTATC 16440

CAAAATCGTC?AAGACATCAT?TTTCTAAAAT?TTTCAATAAT?TTTTGTTCAC?GCAAACTTTG 16500

TTTCATTTTA?ATACTCCTTT?ATTTGTTGAT?ACATCTGCCT?CAAGGCCTGA?TATTTATCTA 16560

TGATACTATG?GTTTTGAATA?ATCTTGTCAA?TTTCTTTGAC?AAATACAGTA?TCTGTGGATA 16620

AAATTTTCAA?ATATTCTTTA?GGAATGCCTC?TCAAATTAAA?ACTAGCGATA?ACGCTAGGGC 16680

TTCCATCTTG?TTTGTAGAGA?ATTTTCCTAT?CTAACCCCTT?AGTGATGATT?TCAAATCTTT 16740

TTCTGTAACA?TGGCTATCTT?TGGTAACAGA?AAGATTGCCC?CCATCGTTTC?TCAAAAAAAT 16800

CTTTGTAGGG?CATTGTTCTC?TAATAGTATC?AGCCATAGGG?CAAGCCAAAA?GATCAGTGAT 16860

GCTTTGAGTC?GCAAGCCTGA?CAATAGCGTT?TCTTTTCCTT?GCAGTTTTTA?GCATGTCTCT 16920

TACAAAATAA?GCAACCTTTG?GATCGCCTAA?ATATTTCCAA?GCTTCATCAA?TATCTAAAAC 16980

AAATCTACGC?CCATCCATTG?CCTCTTGGAT?ACGAGCGAAA?AGGTAAAAAC?AAATAAAGGG 17040

CGAAACATCA?TTATTGTCTA?GGAAACTTGA?CCCATCAACG?CCAATAATCG?TTTTTGAAAA 17100

ATCTAAGCGA?TCGGTTGCTT?GATTATCAAA?AAGCCATTGA?AATTCACCAT?TGGTTGATTT 17160

GCAAAAAGGC?GCTAATCGCG?CGACAAGCCC?ATTAGGATCA?TTGTGGTCTT?TTCCGAAAGC 17220

ATTAATCAGT?TGGGTGATGG?GATAATCTAG?GTTCATATCT?CCTGTGATAA?GGTTGGTTAC 17280

TGCCGCTGCA?AGCGTATTAG?AATCAGCTAG?GCTAAAAGTG?GTGCTGTTGC?CATTTTCATC 17340

TTTTTCATCG?CTTTTGGTTG?CTAAGTTTTT?CACAAGTTCT?TTGACAACAG?AAATAGCTGT 17400

TTGTTTTTGC?TCCATTGTTG?CATTGGATTT?TTGCACACAA?GCCGCCCAAG?CAAAAGGATT 17460

TAATCCTGTA?TCTGTCCCTA?GCTCAATCTT?GACATACTCC?CCACCCATTG?CGACAATATT 17520

CCCATAAGCG?CCATAATCTT?TATCCATATA?GACCATAGTG?AGCTTTTGTC?TGTCTTTGCT 17580

GACATTAGCA?GGAAAATTGT?GAGCAAATTG?TCCCATAGCG?TTTAGAGTCA?TTGACATAAA 17640

CACCGTCTTA?CCTGAACCGG?TTGAGCCAAG?TATCAAAGTG?TGTCCTGCTG?AAGCCGAACC 17700

AAAATCAGTG?GGCATGTGGA?AGTTCAGATA?AAAAGGCGAA?TCGATCTCGC?TTTTTAGCGT 17760

CATGACGCTA?TTACCCCAAG?CGTTATTCTC?TTGATTGCCA?TCAAAACTCA?TCGCTCTCAT 17820

AGCGATAAAA?TCAGCAAAAT?TATTAGAAGT?TACATCAAAA?ATAAAAGGAA?GCGTGATAAA 17880

AGAGCAATGT?TTGGCAAAAA?AGTAATTTTC?CATAGAGAAA?GTCGCTGCGT?TGGCTAAAAA 17940

ACCTTTAGCG?TTAAGACTAG?AGACGCATTC?CTTGACGCTT?TGTTTCATTT?TTTCAAAGCT 18000

ATCAGCAAAC?AGCACTAAAG?AATTACCATA?ACTGCCTAGC?GTAATATCAC?CATTACCCAC 18060

TAATTCACTC?AAGCAACCTA?AAGTCATGCC?CTGCTCTTTA?GAACCCCCAC?TAATAATAAT 18120

CCTTCTAGAG?GTGAAAGCTA?GTTTGTCCTT?TAAAACCTGT?GAGTTTTTAG?GCGAATAAGC 18180

ATGCATAAAG?ATGAACTCGC?TGTCTAGAGC?GTTGATTTTA?TCAAACAAAT?CGCTCTGTGA 18240

TTTAGGGGCG?TATTCACTAA?TCTCAATAGC?GCTAAAATAC?TTTTCACTCA?AATCGTCATT 18300

TAAGATTTTT?CCATGCTTAT?TGGCAAAATA?AACTTCTTTC?ACCCCACCAT?GCATTTTTTC 18360

CTTGAGATAC?AAGTCTTTTC?TGTTGCAAAT?AAAAGGGGCT?TCATTCATTC?CCACAAGAAA 18420

ATTGTAAAAC?TCGCATTGTT?TGGAATAAAC?AACGCCATCT?TTGGTGTATT?CTTTTAATCT 18480

AGTGGGGTGG?TATTTACTCA?ATAGCTCTTC?TATGAGCTCT?ATCCTATCCT?TGAAGTTTTC 18540

AAGCTTGGCT?CTAATAATCC?TTTGAAACTC?TTCAAAATTA?TTGTCTGCAA?AATGCTTTTT 18600

ATTCATAACA?GGTTCATTGA?GAGTGTCTAA?TAAATCTTGC?TCTATGGTCA?GAAAAAAACT 18660

AATATCATAA?AAACTTTCTC?TCTTTTGCTT?CTCATTATAG?GCCCGCATGA?AATCATTAGA 18720

AAAAATAAGA?CTATAGTCCC?TATTGGTTTC?ATCAATAACG?ATTTTCTTTT?TAACAGTGTG 18780

AAAATAAAAT?TTGAATTCAG?GGGTAACAAA?ATTCCTAAAA?ACGCTATAAA?TAGAAGCGTG 18840

TAATTCTATG?AGATCTTTTT?TGGAAGTGGT?TAAAAAATCA?ATGCCCCCCA?ATTTGATTGT 18900

GCCTAAAAGA?GAATAGTTGT?TAGTAAGGAT?CACCCCATCA?TCTAAAAAAC?ATTCATAGTT 18960

ATTCGCTAGA?TAGGAGTTTG?CAGCACTCAC?AAGTCTGTCT?TCTCTGTTTG?GATTTAAGTG 19020

GATGTCATTA?GCCATTTCTT?TACTAGGCTT?CATGGAAAAA?ATGCTCATGA?ATGCTTTGTT 19080

TTTCACGCCC?TTAAACAAAA?AAGGTTTTTT?AAATTTCATC?GCTCGCTCCA?TTCTTTGATA 19140

AAGCCTATAG?TCTTTCTTGA?ATCCAAGAGC?TACAAGCACA?ATAACAATCG?CCACAATCAA 19200

AACAGGTTCA?TAGGCTTGAA?AAAGAATAAC?AGATAATACA?ATTGTTACAA?ACAATATAAA 19260

TATAGAGGAA?TAAATAAAAG?TTTCAGGGAA?ACCAAACAAC?CTATTCCCCC?CATCAAACAA 19320

GACTTTAAAA?AAGGGGTTGA?CACCTTTTTG?CATGTCTGCT?TTAAGCTCTT?CTATTTTTTG 19380

AAACTGCCGC?TTTTGAACCT?CTTGCTCTAT?GATTAGCTTT?TTTTGTTCGT?CAGCTTGCCT 19440

GCTTGCCACA?AACACCCCTC?CCTTTATAGG?TATACCGCTT?CACATGTAAT?CGTATAAAAG 19500

ATTTTTTTGA?GAGACTCTAT?AGCGCTAATA?TGTTTCAAAA?GATCATTAGG?GTCATAAGAA 19560

TTGAATACGG?CCAATAAAAC?ATTATACAGC?TTATCATCGC?ATAGAATTTC?TCTTGTTTCC 19620

CCGTGCAACG?ATAGGAAGCA?GCGTTGTTTG?TTGGTCGTGC?TGATGCTTTT?GAAAGTAAAA 19680

AAGTCTTTCA?CTTCAGGATT?GATCTGCAAT?TCCACATTCA?ACCCCATTTC?TTTACCCTTT 19740

TCATCAAAGA?TTTTTTCAAT?AATTGGATCG?TAATGCTTCA?AATCCTTTAT?TTTTTTAAGG 19800

ACTCTATTGA?CAATCACGAA?ATCAAAAACT?TCATTTTTGA?TAATATCGGG?ATTGATCTCT 19860

TTGAAAGTTA?CTTTCTTGTC?TTGCAAATTT?TTGATAGTCG?CCTTGAAACT?GTCAAAATCT 19920

AAATTCGTAT?AAACACGCCC?ACTAGGAGTG?TTTTTTTCTT?TTTCTAGCGC?TTCTTTTTTC 19980

GCTTGATTAT?CATCATTTGC?CAACCCACAC?GAACTGAAAA?CAACGAGACT?TAAGAGAACT 20040

TTCAAAAAAA?AGTCTCTTAT?TTTTTTATTA?CTATTATTGT?TGATCAATTT?AGCTAGCTCC 20100

TCCACCTTCG?CCAATATTGA?AGCCAAACTT?AGTGCTTAAA?TAGATAATAC?CGCCTGCCAC 20160

CGCTAACATA?GCTATGGGTT?GCGCATAAGC?AAAAACAGTT?GCCTGACCTC?TTTTGATGTC 20220

ATCAGAGATT?TTCCAAATAT?CTGCTATGCC?TTTGACCCCT?AGAGCGCAAC?CACCTACGAT 20280

CGCTAGAACA?GAAATGATCT?GAACAACCAA?AGTTTTAGTC?TCAGTAACGC?CTGTTGCAGG 20340

ACTGTTGAAC?GCCATTAAAG?GATTGGTTGT?TATCGCTAGC?CCTAAAGTTA?CTACAACTTT 20400

CTTGTAGCTG?TCAGTGATTC?TTGTAAGAAA?TTTCATGCGT?TTCCTTTCAA?ATTGAAATCA 20460

ATCGCTTGAG?TATATCAAAA?AAAAAGTATT?TTTATACCAT?TCATACAAGC?ACTACTTCAT 20520

AATTTAAATC?AAAACCGACA?CTTTTGTTTG?ACAATTGGCA?CAATTTAGAA?CAATAAACCT 20580

ACTTGTCCCA?ACCTTTTTTG?TTTCTCAAGT?CGTTGTAGAA?TTGTAGATCT?TTAGGATCTT 20640

TGATGTATTT?TTTAATCGTC?TCAGGTTGAA?ACCTAAAAAC?AAGCAAAAAC?AAACCCAAGC 20700

TGATCAAAGT?GAGAATAAAG?CTCCATTTTA?AGCAACTCCA?TAGACCACTA?AAGAAACTTT 20760

TTTTGAAGCT?GTCTTTGAAA?ATCTGTCCTA?TTGATTTATT?TTCCATGTGG?ATCGCAAACA 20820

CTTCTTGTTA?AAATTTGTCT?ATTTTAGCGA?GTTTTTGTCA?ATTATAGGTA?AAAATGTGAA 20880

TCGTTCCTAG?CCTTTAGACG?CTTGCAACGA?CTGGAATTTT?TCAATATTAA?CAATATTAAT 20940

GAAAAAATGC?CTAATATTGT?GGTATAATAA?GAATGTTCAA?AGACATCAAT?TGACCACTCA 21000

AGCGTGTGGT?GGTTTTTAGC?AGTCTTTGAT?ACCAAATTAG?GTTAGTAAGG?AGAAACAATG 21060

ACTAACGAAA?CCATCGATCA?AACAACAACA?CCAGATCAAA?CAGATTTTGT?TCCGCAACGA 21120

TTTATCAATA?ATCTTCAAGT?AGCTTTTCTT?AAAGTTGATA?ACGCTGTCGC?TTCATTTGAT 21180

CCCGATCAAA?AACCAATCGT?TGATAAGAAT?GATAGGGATA?ATAGGCAAGC?TTTTGAGAAA 21240

ATCTCGCAAC?TAAGGGAAGA?ATACGCCAAT?AAAGCGATCA?AAAATCCTGC?CAAAAAGAAT 21300

CAGTATTTTT?TTAGACTTTA?TCAATAAGAG?CAATGATTTA?ATCAACAAAG?ACAATCTCAT 21360

TGCTGTAGAT?TCTTCCGTAG?ATAGCTTTAA?GAAATTTGGG?GATCAGCGTT?ACCAAATTTT 21420

TACGAGTTGG?GTGTCCCTTC?AAAAAGATCC?GTCTAAAATC?AACACCCAAC?AAATTCCGAA 21480

ATTTTATGGA?AAATATCATA?CAACCCCCTA?TCTCTGATGA?TAAGGAAAAA?GCGGAGTTTT 21540

TGAGGTCTGC?CAAACAATCT?TTTGCAGGAA?TTATCATAGG?GAACCAAATC?CGATCGGATC 21600

AAAAGTTCAT?GGGCGTGTTT?GATGAATCTT?TGAAAGAAAG?GCAAGAAGCA?GAAAAAAATG 21660

CAGAGCCTGC?TGGTGGGGAT?TGGCTTGATA?TTTTTTTATC?ATTTGTATTC?AATAAAAAAC 21720

AATCTTCCGA?TCTCAAAGAA?ACGCTCAATC?AAGAGCCAAG?GCCTGATTTT?GAACAAAATT 21780

TAGCCACTAC?CACCACTGAC?ATACAAGGCT?TACCGCCTGA?AGCTAGAGAT?TTGCTTGATG 21840

AAAGGGGTAA?TTTTTTTAAA?TTCACTCTTG?GTGATGTGGA?GATGTTGGAT?GTTGAGGGAG 21900

TCGCTGACAA?GGATCCCAAT?TATAAGTTCA?ATCAATTGTT?GATCCACAAT?AACGCTCTAT 21960

CTTCTGTGCT?AATGGGGGGT?CATAGTAACA?TAGAACCTGA?AAAAGTTTCA?TTATTGTATG 22020

GGGATAATGG?TGGTCTTGAA?GCTAGGCATG?ATTGGAACGC?CACCGTTGGT?TATAAAAACC 22080

AACAAGGCAG?TAATGCGGCC?ACACTCATTA?ATGCGCATCT?TAATAACGGC?AGCGGGTTAA 22140

TCATAGCGGG?TAATGAGGAT?GGGATTAAAA?ACCCTAGCTT?CTATCTCTAC?AAAGAAGAGC 22200

AACTCACAGG?CTTGAAACAA?GCGTTGAGTC?AAGAAGAGAT?CCAAAACAAA?GTGGATTTCA 22260

TGGAATTTCT?CGCACAAAAC?AATGCTAAAT?TAGACAACTT?GAGCAAGGAA?GAGAAAGAAA 22320

AATTCCAAAC?TGAGATTGGA?AATTTCCAAA?AAGACCGTAA?GGCTTATTTG?GACGCTCTAG 22380

GGAATGATCA?CATTGCTTTT?GTTTCTAAAA?AAGACCCAAA?ACATTTAGCT?TTGGTTACTG 22440

AGTTTAGTAA?TGGGGAATTG?AGCTATACTC?TCAAAGATTA?TGGGAAAAAA?CAAGATAAAG 22500

CTTTAGATGG?GGAGACAAAA?ACCACTCTTC?AAGGTAGCCT?AAAATATGAT?GGCGTGATGT 22560

TTGTCAATTA?TTCCAATTTC?AAATACACCA?ACGCCTCCAA?GAGTCCTGAT?AAGGGCGTGG 22620

GCACTACGAA?TGGCGTTTCC?CATTTGGAAG?CAAATTTTAG?CAAGGTAGCT?GTCTTTAATT 22680

TGCCTAATTT?AAATAATCTC?GCTATCACTA?ATTATATAAG?GCGAGATTTA?GAAGATAAAT 22740

TGTTGGCTAA?AGGATTGTCC?CCACAAGAAG?CTAATAAGCT?CATCAAAGAC?TTTTTGAACA 22800

GCAACAAAGA?ATTGGTTGGA?AAAGTTTCAA?ACTTCAATAA?AGCTGTAGCT?GAAGCTAAAA 22860

ACACAGGCAA?TTATGACGAA?GTGAAAAAAG?CTCAGAAAGA?TCTTGAAAAA?TCTCTAAGGA 22920

AACGAGAGCA?TTTAGAGAAA?GAAGTAGCGA?AAAAATTGGA?GAGCAGAAAC?GACAACAAAA 22980

ATAGAATGGA?AGCAAAAGCT?CAAGCTAACA?GCCAAAAAGA?TAAGATTTTT?GCACTTATCA 23040

ATAAAGAGGC?TAGTAAGGAA?GCAAGAGCGG?CCGCTTTCGA?TCCGAATCTT?AAAGGCATCA 23100

GGAGCGAATT?GTCTGATAAA?CTTGAAAATA?TCAACAAGAA?TTTGAAAGAC?TTTGGCAAAT 23160

CTTTTGATGA?ACTCAAAAAT?GGCAAAAATA?ATGATTTCAG?CAAGGCAGAA?GAAACGCTAA 23220

AAGCCCTTAA?AGACTCGGTG?AAAGATTTAG?GCATCAATCC?AGAATGGATT?TCAAAAATTG 23280

AAAACCTTAA?TGCAGCTTTG?AATGATTTCA?AAAATGGCAA?AAATAAGGAT?TTCAGCAAGG 23340

TAACACAGGC?AAAAAGCGAC?CTTGAAAATT?CCATTAAGGA?TGTGATCATC?AATCAAAAGA 23400

TAACGGATAA?AGTTGACAAT?CTCAATCAGG?CGGTATCAGA?GACTAAATTA?ACAGGCAATT 23460

TCAGTAAGGT?AGAGCAAGCT?CTAGCCGAAT?TCAAAAGCTT?GTCATTGGAT?CTTGGAAAAA 23520

ATTCTGATCT?ACAATCCGTT?AAAAATAGTA?TAAATGGAAC?CCTAGTCGGT?AATGGGTTGT 23580

CTAAAACAGA?AGCCACAACG?CTCACCAAAA?ATTTTTCGGA?CATTAGGAAA?GAATTGAACG 23640

AGAAATTATT?TGGAAATTCC?AATAACAATA?ATAATGGACT?CAAGAACAAC?ACAGAGCCCA 23700

TTTATGCTCA?AGTTAATAAA?AAGAAAGCAG?GACAAGTAGC?TAGCCCTGAA?GAGCCCATTT 23760

ACGCTCCAAG?TTGCTAAAAA?GGTGAGTGCA?AAAATTGACC?AACTCAACAA?AGCTACATCA 23820

GCAATAAATA?GAAAAATTGA?CCGGATTAAC?AAAATTGCAT?CAGCAGGTAA?AGGAGTGGGC 23880

GGTTTCAGTG?GAACAGGGCG?ATCAGCTAGC?CCTGAACCCA?TTTACGCTAC?AATTGATTTT 23940

GATGAGGCAA?ATCAAGCAGG?CTTCCCTCTT?AGGAGAAGTG?CTGCAGTTAA?TGATCTCAGT 24000

AAAGTAGGGC?TTTCAAGGGA?GCAAGAATTG?ACTCGTAGAA?TTGGCGATCT?CAATCAGGCG 24060

GTATCAGAAG?CTAAAACAGG?TCATTTTGGC?AAACTAGAAC?AAAAGATAGA?TGAACTCAAA 24120

GATTCTACGA?AAAAGAATGC?TTTGAAGTTA?TGGGTTGAAA?GCGCGAAACA?AGTGCCTACT 24180

AGTTTGCAGG?CGAAATTGGA?CAATTATGCT?ACTAACAGCC?ACACACGCAT?TAATAGCAAT 24240

GTCCAAAATG?GAGGAATTAA?TGAGAAAGCG?ACCGGTATGC?TAACGCAAAA?AAACCCTGAG 24300

TGGCTCAAGC?TCGTGAATGA?TAAGATAGTT?GCGCATAATG?TGGGAAGTGC?TCATTTGTCA 24360

GAGTATGATA?AAATTGGATT?CAACCAAAAG?AATATGAAAG?ATTA 24404

Claims (8)

1. helicobacter pylori pathogenicity island disease gene detection chip, it is characterized in that: be set with probe on the described chip, described probe comprises the PCR product of 85% above conserved sequence among the SEQ ID NO:1-26, described PCR product is to design Auele Specific Primer with international standard bacterial strain HP26695 sequence for reference sequences, the genomic dna that extracts with clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain obtains through the PCR reaction as template.

2. a kind of helicobacter pylori pathogenicity island disease gene detection chip as claimed in claim 1 is characterized in that: also be set with the cag pathogenicity island gene specific oligonucleotide among the SEQ ID NO:27-40 on the described chip.

3. a kind of helicobacter pylori pathogenicity island disease gene detection chip as claimed in claim 1 is characterized in that: described PCR product designs Auele Specific Primer with the sequence of international standard bacterial strain J99 for reference sequences.

4. the making method of the described helicobacter pylori pathogenicity island disease gene detection chip of claim 1 is characterized in that, comprising: choose representative bacterial strain in the H.pylori infected patient, measure its whole genome sequence; Compare with known reference culture HP26695 sequence, find out the dna sequence polymorphism feature; With reference to conserved sequence design PCR primer, the genomic dna that clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain is extracted is as template, obtains product as one of probe of DNA gene chip through the PCR reaction; Obvious and the conserved sequence shorter one for gene inside polymorphism, the oligonucleotide fragment of increase over-designed sequence open reading frame fragment correspondence; Manufacture craft according to the DNA gene chip prepares the DNA gene chip.

5. the making method of helicobacter pylori pathogenicity island disease gene detection chip according to claim 4 is characterized in that, comprises the following steps:

A) in the H.pylori infected patient, choose patients with gastric cancer, duodenal ulcer patients or chronic gastritis patient, obtain representative bacterial strain, and order-checking obtains its whole genome sequence;

B) compare with known reference culture HP26695 sequence, and different representative strain cag pathogenicity island gene orders are compared, seek specific dna polymorphism feature;

C) with reference to conserved sequence design PCR primer, the genomic dna that clinical isolating Chinese population disease specific helicobacter pylorus bacteria strain is extracted is as template, obtains product as one of probe of DNA gene chip through the PCR reaction; Obvious and the conserved sequence shorter one for gene inside polymorphism, the oligonucleotide fragment of increase over-designed sequence open reading frame fragment correspondence, synthetic this fragment is as extra probe;

D) according to the manufacture craft of DNA gene chip, probe is imprinted on pretreated slide through the point sample instrument point,, makes finished product DNA gene chip through technique for fixing.

6. as the making method of claim 4 or 5 described helicobacter pylori pathogenicity island disease gene detection chips, it is characterized in that: compare with the sequence of known reference culture J99, find out the dna sequence polymorphism feature.

7. the quality control of the described helicobacter pylori pathogenicity island disease gene detection chip of claim 1 and detection efficiency verification method is characterized in that, comprise the following steps:

A) the equivalent DNA sample to be measured that derives from helicobacter pylori genome DNA to be measured obtains different fluorescently-labeled hybridization samples through the reverse transcription of nine aggressiveness Cy3-dCTP or Cy5-dCTP fluorescent mark raw material at random;

B) sample purifying;

C) chip hybridization experiment;

D) the machine fluorescent scanning obtains the hybridization signal data as calculated;

E) the fluorescent signal data are calculated the Ratio value of Cy5/Cy3 through standardization, and are all

The corresponding Ratio value of hybridization point all is qualified between 0.5-2.0.

8. the using method of the described helicobacter pylori pathogenicity island disease gene detection chip of claim 1 is characterized in that, comprises the following steps:

A) the helicobacter pylori infection person gastric mucosa tissue sample that obtains of gastroscopy obtains bacterial strain to be measured through separating, cultivating 48 hours, and obtains the genomic dna of bacterial strain to be measured through DNA separation and purification operation;

B) relevant aforesaid method obtains fluorescent mark sample to be measured (reference culture DNA is with the Cy3 fluorescent mark, and bacterial strain DNA to be measured is with the Cy5 mark);

C) carry out chip hybridization experiment, the line data analysis of going forward side by side.