CN1792383A - Bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material - Google Patents
Bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material Download PDFInfo
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- CN1792383A CN1792383A CN 200510111794 CN200510111794A CN1792383A CN 1792383 A CN1792383 A CN 1792383A CN 200510111794 CN200510111794 CN 200510111794 CN 200510111794 A CN200510111794 A CN 200510111794A CN 1792383 A CN1792383 A CN 1792383A
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Abstract
A medical Mg-Zn-Ca alloy material absorbable in biologic body is proportionally prepared from high-purity full-nutritive Mg and Zn to form MgZn phase for high strength and anticorrosion nature, and Ca for fining grains for high strength and plasticity. It has high biocompatibility and mechanical performance and can be used for intravescular scaffold, bone nail, bone plate, etc.
Description
Technical field
What the present invention relates to is a kind of complex magnesium alloy of biomedical materials field, specifically, is a kind of bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material.
Background technology
Biological degradable in vivo absorbing material is one of important directions of biomaterial development, and the biological degradable in vivo absorbing material of research and development mainly is polymeric material and some ceramic material at present, as polylactic acid, polycaprolactone, calcium phosphate etc.But because the common plasticity and toughness lower, ceramic material of the mechanical property of polymeric material are relatively poor, metal material then has better comprehensive mechanical property, and therefore, the biological degradable in vivo absorbing material of Metal Substrate has important medical applications and is worth.Magnesium is one of the abundantest element of reserves on the earth, also is second cation the abundantest in the 4th, cell in the human body, is indispensable important nutrient in the human body, and total amount about more than 20 restrains in human body.Magnesium promotes the formation of bone and cell in life process, catalysis or activation body 300 plurality of enzymes system participate in the energy i (in vivo) metabolism, and are crucial elements in conveying, storage and the utilization of energy.Magnesium plays a crucial role to proteinic synthesizing by the structure of regulating rDNA and RNA in the three big metabolism in vivo.The balance adjustment of magnesium is finished by intestinal absorption and renal excretion in the human body.Magnesium has important function to nerve, muscle and the cardiac function of human body, and magnesium deficiency is one of etiology factor of some severe arrhythmia, ischemic heart desease, hypertension, particularly arteriosclerosis, myocardial infarction, sudden death.Magnesium has good medical science safety basis as bio-medical material, is particularly useful in the treatment of cardiovascular disease.
Find through literature search prior art, people such as B.Heublein in " Heart " (heart) magazine 2003 89 volume 651-656 page or leaf, reported " Biocorrosion of Magnesium Alloys:A NewPrinciple in Cardiovascular Implant Technology? " (corrosion biology of magnesium alloy: a kind of new principle of cardiovascular implanted prosthetics?), they are by animal (pig) experimentation AE21 magnesium alloy (Mg-2%Al-1%Re, its middle rare earth Re comprises Ce, Pr, the Nd element) is used as the feasibility of the support of cardiovascular interventional therapy, the biocompatibility that found that magnesium alloy is good, do not produce problems such as thromboembolism behind the implantable intravascular, have good application potential.Contain Al element and rare earth element in the magnesium alloy of studying in the document, though the biocompatibility of magnesium basis is good, but the Al element does not belong to the essential trace element of human body, be considered to have neurotoxicity, it is the factor that causes presenile dementia, and also there is dispute in the biocompatibility of rare earth element, it is generally acknowledged that rare earth element accumulation in vivo will show as toxic action.And existing Mg-Zn and Mg-Zn-Ca ternary magnesium alloy material thereof all are to be applied in the general industry, do not find the complex magnesium alloy material of Mg-Zn base is applied to the report of bio-medical material so far as yet.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, the ternary magnesium alloy material of a kind of organism absorbable Mg-Zn-Ca is provided, make it, overcome technology prejudice as bio-medical material.The present invention utilizes the chemical reaction of magnesium in aqueous medium to change magnesium ion into, and magnesium ion comes adjustment by the metabolism of intravital absorption and kidney, thereby magnesium alloy materials is degraded and absorbed in vivo gradually.Material of the present invention has excellent biological compatibility and mechanical property, has important use at medical domains such as the support of vascular interventional treatment and absorbable nail, hone lamellas and is worth.
The present invention is achieved by the following technical solutions, and component of the present invention and percentage by weight are: Zn1-8%, and Ca 0.1-2%, surplus is Mg.
For obtain best comprehensive mechanical property and biology corrosive nature, weight percentage ranges further is Zn 6 ± 0.5%, Ca 0.5 ± 0.1%, surplus is Mg.In this scope, Tensile strength of the present invention reaches about 300MPa, and plasticity is maintained at about 8-10%, and the excellent combination of this intensity and plasticity can guarantee the requirement to the strength of materials of the Deformation Properties of Al of material and medical applications.Simultaneously, its corrosive nature biology in biological fluid or blood environment is good, by its absorbed speed of scalable such as composition, ion concentration and pH value in control body fluid or the blood environment, thus when satisfying treatment to the requirement of mechanical property retention time of medical apparatus and instruments.
Mg-Zn-Ca ternary magnesium alloy material of the present invention must adopt the melting technique of highly purified raw material and high-cleanness, high to make.The degree of purity of raw material Mg is not less than 99.99%, and the degree of purity of Zn is more than or equal to 99.999%, and the degree of purity of Ca is more than or equal to 99.75%.High clean melting need be adopted the noble gas argon shield, adopts special-purpose graphite or titanium crucible for smelting, and smelting temperature is poured into a mould ingot casting then at about 750 ℃ in a kind of iron mould of special use.Ingot casting is made required section bar again after heat treatment and deformation processing, make the various medical apparatus and instruments that implant from section bar and use.
The ternary magnesium alloy system that the present invention is made up of full nutritive element Mg, Zn, Ca.Zn can form the MgZn phase as alloying element important among the Mg, not only improves the intensity of magnesium, also improves the corrosive nature of magnesium.Ca has the effect of crystal grain thinning, thus the intensity of raising magnesium and plasticity etc.Simultaneously, Zn is the element that cell growth is grown material impact, and Ca is the main component of bone.Mg, Zn, Ca are the necessary nutrients of human body, therefore, the alloy system of being made up of them has excellent biological compatibility and mechanical property basis, can satisfy the requirement of medical application fields such as endovascular stent, nail, hone lamella to material comprehensive mechanical property and biological safe preferably.
The specific embodiment
Embodiment 1
Ternary Mg-Zn-Ca alloy material, wherein wt percentage ratio Zn is 1%, Ca is 0.1%.The degree of purity of raw material Mg is not less than 99.99%, and the degree of purity of Zn is more than or equal to 99.999%, and the degree of purity of Ca is more than or equal to 99.75%.After high-cleanness, high melting under argon shield and casting, after Overheating Treatment and deformation processing, make required section bar again and use.This material has excellent biological compatibility and mechanical property, and its tensile strength is 230MPa, and plasticity is 12%, can be in biological fluid or blood environment degraded and absorbed.
Embodiment 2
Ternary Mg-Zn-Ca alloy material, wherein wt percentage ratio Zn is 6%, Ca is 0.5%.The degree of purity of raw material Mg is more than or equal to 99.99%, and the degree of purity of Zn is more than or equal to 99.999%, and the degree of purity of Ca is more than or equal to 99.75%.After high-cleanness, high melting under argon shield and casting, after Overheating Treatment and deformation processing, make required section bar again and use.This material has excellent biological compatibility and mechanical property, and its tensile strength is 300MPa, and plasticity is 8%, can be in biological fluid or blood environment degraded and absorbed.
Embodiment 3
Ternary Mg-Zn-Ca alloy material, wherein wt percentage ratio Zn is 8%, Ca is 2%.The degree of purity of raw material Mg is more than or equal to 99.99%, and the degree of purity of Zn is more than or equal to 99.999%, and the degree of purity of Ca is more than or equal to 99.75%.After high-cleanness, high melting under argon shield and casting, after Overheating Treatment and deformation processing, make required section bar again and use.This material has excellent biological compatibility and mechanical property, and its tensile strength is 260MPa, and plasticity is 2%, can be in biological fluid or blood environment degraded and absorbed.
Claims (5)
1, a kind of bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material is characterized in that, component and percentage by weight are: Zn 1-8%, and Ca 0.1-2%, surplus is Mg.
2, bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material according to claim 1 is characterized in that, component and percentage by weight are: Zn 6 ± 0.5%, and Ca 0.5 ± 0.1%, and surplus is Mg.
3, according to claim 1 or 2 described bio-absorbable Mg-Zn-Ca three-elements magnesium alloy materials, it is characterized in that the degree of purity of Mg is more than or equal to 99.99%.
4, according to claim 1 or 2 described bio-absorbable Mg-Zn-Ca three-elements magnesium alloy materials, it is characterized in that the degree of purity of Zn is more than or equal to 99.999%.
5, according to claim 1 or 2 described bio-absorbable Mg-Zn-Ca three-elements magnesium alloy materials, it is characterized in that the degree of purity of Ca is more than or equal to 99.75%.
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| CN 200510111794 CN1792383A (en) | 2005-12-22 | 2005-12-22 | Bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material |
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| CN 200510111794 CN1792383A (en) | 2005-12-22 | 2005-12-22 | Bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material |
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| CN100409904C (en) * | 2006-08-14 | 2008-08-13 | 大连富精医疗器械有限公司 | Biodegradable magnesium alloy blood vessel rack |
| US20100075162A1 (en) * | 2006-09-22 | 2010-03-25 | Seok-Jo Yang | Implants comprising biodegradable metals and method for manufacturing the same |
| CN101015711B (en) * | 2007-02-07 | 2010-05-19 | 北京大学 | Medical implantation material capable of by degraded by body fluid and its preparing process |
| CN102085387A (en) * | 2010-12-20 | 2011-06-08 | 苏州奥芮济医疗科技有限公司 | In vivo absorbable metal intervertebral fusion cage |
| CN102100579A (en) * | 2011-04-01 | 2011-06-22 | 苏州奥芮济医疗科技有限公司 | In vivo degradable and absorbable metal encirclement device for bone fracture internal fixation |
| CN102618829A (en) * | 2011-01-31 | 2012-08-01 | 乐普（北京）医疗器械股份有限公司 | Medical magnesium alloy material with amorphous film and preparation method thereof |
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| CN103614601A (en) * | 2013-12-16 | 2014-03-05 | 苏州奥芮济医疗科技有限公司 | In-vivo controlled degradable bacteriostatic Mg-Ag-Zn-Mn magnesium alloy implant material and preparation method thereof |
| CN103830773A (en) * | 2009-04-22 | 2014-06-04 | 友和安股份公司 | Biodegradable implant and method for manufacturing same |
| CN103993187A (en) * | 2014-05-21 | 2014-08-20 | 太原理工大学 | Preparation method of medical degradable magnesium-bismuth alloy plate |
| US20150129092A1 (en) * | 2012-06-26 | 2015-05-14 | Biotronik Ag | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
| KR20150130488A (en) * | 2013-03-14 | 2015-11-23 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | Magnesium alloy with adjustable degradation rate |
| CN105765095A (en) * | 2013-10-03 | 2016-07-13 | 安内利-马丁纳·温伯格 | Implant, method for production thereof and use thereof |
| WO2018079923A1 (en) * | 2016-10-31 | 2018-05-03 | 한국과학기술연구원 | Biodegradable magnesium alloy and manufacturing method therefor |
| TWI640638B (en) * | 2012-08-31 | 2018-11-11 | 瑞士商星瑟斯有限公司 | Ultrapure magnesium alloy with adjustable degradation rate |
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| US10895000B2 (en) | 2012-06-26 | 2021-01-19 | Biotronik Ag | Magnesium alloy, method for the production thereof and use thereof |
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2005
- 2005-12-22 CN CN 200510111794 patent/CN1792383A/en active Pending
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| CN100409904C (en) * | 2006-08-14 | 2008-08-13 | 大连富精医疗器械有限公司 | Biodegradable magnesium alloy blood vessel rack |
| US20100075162A1 (en) * | 2006-09-22 | 2010-03-25 | Seok-Jo Yang | Implants comprising biodegradable metals and method for manufacturing the same |
| CN102512711A (en) * | 2006-09-22 | 2012-06-27 | 友和安股份公司 | Implants comprising biodegradable metals and method for manufacturing the same |
| CN101516292B (en) * | 2006-09-22 | 2013-08-21 | 友和安股份公司 | Implants comprising biodegradable metals and method for manufacturing the same |
| CN101015711B (en) * | 2007-02-07 | 2010-05-19 | 北京大学 | Medical implantation material capable of by degraded by body fluid and its preparing process |
| EP2422821B1 (en) | 2009-04-22 | 2018-11-28 | U & I Corporation | Biodegradable implant and method for manufacturing same |
| CN103830773A (en) * | 2009-04-22 | 2014-06-04 | 友和安股份公司 | Biodegradable implant and method for manufacturing same |
| CN102085387A (en) * | 2010-12-20 | 2011-06-08 | 苏州奥芮济医疗科技有限公司 | In vivo absorbable metal intervertebral fusion cage |
| CN102618829B (en) * | 2011-01-31 | 2014-08-13 | 乐普（北京）医疗器械股份有限公司 | Medical magnesium alloy material with amorphous film and preparation method thereof |
| CN102618829A (en) * | 2011-01-31 | 2012-08-01 | 乐普（北京）医疗器械股份有限公司 | Medical magnesium alloy material with amorphous film and preparation method thereof |
| CN102100579A (en) * | 2011-04-01 | 2011-06-22 | 苏州奥芮济医疗科技有限公司 | In vivo degradable and absorbable metal encirclement device for bone fracture internal fixation |
| RU2640700C2 (en) * | 2012-06-26 | 2018-01-11 | Биотроник Аг | Magnesium alloy, method of its manufacture and use |
| US10344365B2 (en) | 2012-06-26 | 2019-07-09 | Biotronik Ag | Magnesium-zinc-calcium alloy and method for producing implants containing the same |
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| EP3693482A1 (en) * | 2012-06-26 | 2020-08-12 | Biotronik AG | Implant made from magnesium-zinc-calcium alloy |
| EP3693481A1 (en) * | 2012-06-26 | 2020-08-12 | Biotronik AG | Magnesium alloy, method for the production thereof and use thereof |
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| US10358709B2 (en) | 2012-06-26 | 2019-07-23 | Biotronik Ag | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
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| CN103614601B (en) * | 2013-12-16 | 2016-04-06 | 苏州奥芮济医疗科技有限公司 | The antibacterial magnesium alloy implant material of controlled degradation Mg-Ag-Zn-Mn and preparation thereof in organism |
| CN103614601A (en) * | 2013-12-16 | 2014-03-05 | 苏州奥芮济医疗科技有限公司 | In-vivo controlled degradable bacteriostatic Mg-Ag-Zn-Mn magnesium alloy implant material and preparation method thereof |
| CN103993187A (en) * | 2014-05-21 | 2014-08-20 | 太原理工大学 | Preparation method of medical degradable magnesium-bismuth alloy plate |
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