CN1791374A - Nipple device - Google Patents
Nipple device Download PDFInfo
- Publication number
- CN1791374A CN1791374A CNA2004800136970A CN200480013697A CN1791374A CN 1791374 A CN1791374 A CN 1791374A CN A2004800136970 A CNA2004800136970 A CN A2004800136970A CN 200480013697 A CN200480013697 A CN 200480013697A CN 1791374 A CN1791374 A CN 1791374A
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- China
- Prior art keywords
- nipple
- medicine container
- lid
- container
- keeps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J11/00—Teats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J17/00—Baby-comforters; Teething rings
- A61J17/001—Baby-comforters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0053—Syringes, pipettes or oral dispensers
Abstract
A nipple device (10) has a nipple (11), and a nipple holder (15) for holding the nipple (11). The nipple holder (15) is internally provided with a liquid-permeable body (25) and has a cap (17) mounted thereon. A medicine container (20) covered by a film (21) is received in the cap (17). When the cap (17) is mounted on the nipple holder (15), a projection (19) on the nipple holder (15) pricks the film (21).
Description
Technical field
The present invention relates to can be to the throw something and feed nipple device of medicament of newborn child.
Background technology
Always, as the nipple of the medicament of when the baby licks the lane, throwing something and feeding, the known nipple (for example with reference to special table 2001-511644 communique) that has the baby who has filled medicament to lick the lane.
The nipple that this baby licks the lane has suction inlet, and tablet is disposed at the vacancy of this suction inlet.By newborn child is kept in the mouth this suction inlet, tablet is thrown something and fed to newborn child.
Though the baby in above-mentioned prior art licks in the nipple of lane, tablet is disposed at the vacancy of suction inlet, when nipple from the lane to this baby that lick replenishes tablet, then tablet must be disposed at the vacancy of suction inlet, and its adjunctive program is numerous and diverse.
In addition, though be necessary to clean termly the nipple that the baby licks the lane, be to constitute because the baby licks the nipple of lane, so can't carry out the container washing and cleaning operation integratedly.
Summary of the invention
The present invention considers this problem and makes that purpose is to provide a kind of nipple device that replenishes and clean that can easily carry out medicament.
Nipple device of the present invention has: nipple keeps the nipple of nipple to keep body, and is sticked in the lid on the nipple maintenance body; Be provided with medicine container portion in lid, medicament is filled within it, and nipple one side is covered by thin film; Keep being provided with the portion of breaking on the body at nipple, when lid is sticked on the nipple maintenance body, thin film is punctured.
Nipple device of the present invention is characterised in that, keeps being provided with on the body liquid that extends at nipple in nipple and sees through body, and nipple keeps the portion of breaking of body to be made of the projection of thrusting thin film.
Nipple device of the present invention is characterised in that, keeps being provided with external screw thread on the body at nipple, is provided with the female thread that engages with this external screw thread on lid.
Nipple device of the present invention is characterised in that liquid sees through body and constitutes by the plate body on the thin film that is connected to medicine container portion and from the clava of this plate body to the extension of nipple one side.
Nipple device of the present invention is characterised in that, sees through on the plate body of body at liquid and is provided with opening, and it is side-prominent to medicine container portion one that projection is passed this opening from nipple one side.
Nipple device of the present invention is characterised in that medicine container portion is made of the medicine container that is located in the lid.
Nipple device of the present invention is characterised in that medicine container portion is by being constituted by the zone that thin film marked in the lid.
Nipple device of the present invention is characterised in that, nipple keep body have with nipple in the connected space that is communicated with, this connected space is located at medicine container portion one side, is had the division wall covering of connected entrance.
Nipple device of the present invention is characterised in that nipple keeps the portion of breaking of body to be made of the end of dividing wall.
Nipple device of the present invention is characterised in that, is provided with the check valve that makes medicament keep body to flow into from medicine container portion to nipple on the opening of dividing wall.
Nipple device of the present invention is characterised in that, have: nipple, keep nipple and have the nipple maintenance body of the container resettlement section that is communicated with nipple one side, and swing is installed on the nipple maintenance body and the lid of covering container resettlement section freely, in the container resettlement section, dispose medicine container, medicament is filled within it, and has opening in nipple one side.
Nipple device of the present invention is characterised in that, is provided with on the container resettlement section to the side-prominent cylinder guider of nipple one, and medicine container has the outlet of inserting in this cylinder guider.
Nipple device of the present invention is characterised in that medicine container can freely take off from the container resettlement section, is provided with the engaging fin on lid, engages with the cylinder guider of container resettlement section.
Nipple device of the present invention is characterised in that medicine container is made of flexible material and is fixed in the container resettlement section, is provided with the press section of extruding medicine container on lid.
Nipple device of the present invention is characterised in that medicament contains the xylitol composition.
Nipple device of the present invention is characterised in that medicament contains virus and catches constituent.
Nipple device of the present invention is characterised in that virus is caught constituent and contained the water extract of Nidus collocaliae and/or the enzyme handled thing of Nidus collocaliae as effective ingredient.
Description of drawings
Fig. 1 is the sectional view of expression according to the 1st embodiment of nipple device of the present invention.
Fig. 2 is the exploded view of nipple device.
Fig. 3 be among Fig. 1 III line direction to view.
Fig. 4 is the sectional view of expression according to the 2nd embodiment of nipple device of the present invention.
Fig. 5 is the exploded view of nipple device.
Fig. 6 is the sectional view of expression according to the 3rd embodiment of nipple device of the present invention.
Fig. 7 is the partial sectional view of nipple device.
Fig. 8 is the figure of expression according to the variation of nipple device of the present invention.
Fig. 9 is the figure of expression according to the variation of nipple device of the present invention.
Figure 10 is the chart that expression investigation virus is caught the active result of influenza virus infection neutralization of constituent.
Figure 11 is the chart that expression investigation virus is caught the result of the sialic acid molecule kind that contained in the constituent and content.
Figure 12 is that expression investigation is caught the glycopeptide that is contained in the constituent by the SDS-PAGE isolated viral, with the result's of the associativity of influenza virus figure.
The specific embodiment
Below, describe with regard to embodiments of the present invention with reference to accompanying drawing.
Fig. 1 to Fig. 3 is the figure of expression according to the 1st embodiment of nipple device of the present invention.Wherein, Fig. 3 be among Fig. 1 III line direction to view.
As shown in Fig. 1 to Fig. 3, nipple device 10 has the nipple 11 that newborn child keeps in the mouth, and keeps the nipple of nipple 11 to keep body 15, and the liquid that keeps body 15 to extend in nipple 11 from nipple sees through body 25, and is sticked in the lid 17 on the nipple maintenance body 15.
Be provided with in lid 17 and filled liquid medicament, for example added the medicine container (medicine container portion) 20 of liquid medicament of the xylitol composition of caries prevention, nipple 11 1 sides of this medicine container portion 20 are covered by silver-colored paper or resinous thin film 21.Keep being provided with on the body 15 projection 19 when lid 17 is fastened on the nipple maintenance body 15 at nipple, thrust the thin film 21 of medicine container 20.This projection 19 is when lid 17 is sticked in nipple maintenance body 15, as making the thin film 21 disruptive portion's performance functions of breaking.
Next the component parts with regard to each one is explained in more detail.At first, nipple 11 comprises nipple body 11a cylindraceous and is located at tabular base end part 11b on the cardinal extremity of this nipple body 11.On nipple body 11a, be provided with perforate 12, supply with via liquid to foreign side and see through the medicament that body 25 is sent here.
In addition, nipple keeps body 15 to comprise cylindrical portion 15a and the diameter large-diameter portion 15b greater than this cylindrical portion 15a.The base end part 11b of nipple 11 inserts in the large-diameter portion 15b that is fixed in nipple maintenance body 15, and then keeps frame 13 to embed in the large-diameter portion 15b from the foreign side of base end part 11b.So, nipple 11 just keeps body 15 to be kept by nipple.
In addition, medicine container 20 enters in the cylindrical portion 15a of nipple maintenance body 15, and this medicine container 20 is bonded on the lid 17.
Nipple 11 1 sides of medicine container 20 are covered by thin film 21 as previously mentioned, and this thin film 21 keeps the projection 20 of body 15 easily to pierce through and breakage by nipple.
In addition, liquid sees through body 25 and comprises and be the shape identical with the thin film 21 of medicine container 20, the clava 25a that is connected to the discoideus plate body 25b on this thin film 21 and extends to nipple 11 1 sides from plate body 25b.Liquid sees through body 25 as totally being made up of sponge material, and the medicament in the medicine container 20 is seen through to nipple 11 1 sides.
In addition, on liquid sees through the plate body 25b of body 25, be formed be positioned at clava 25a below opening 26.By in the opening 26 of this plate body 25b, inserting the fixedly projection 19 of nipple maintenance body 15, can keep body 15 positioning and fixing liquid to see through body 25 by nipple.
In addition, the clava 25a that liquid sees through body 25 preferably has the identical outside shape of interior shape with the nipple body 11a of nipple 11, in this case, can see through body 25 by nipple body 11a positioning and fixing liquid.
Moreover nipple keeps the projection 19 of body 15 to remain between cylindrical portion 15a and the large-diameter portion 15b front end taper of thin film 21 sides of medicine container 20.
In addition, keep at nipple being provided with external screw thread 16 on the outside of cylindrical portion 15a of body 15, be provided with the female thread 18 that engages with external screw thread 16 being placed on 17 the inner face.But, can not engage yet, and engage cylindrical portion 15a and lid 17 by simple embedding by the card stricture of vagina,
Can not be how, nipple keeps body 15 cylindrical portion 15a and lid 17 to engage with sealing state.
Next just describe by this effect that constitutes the present embodiment of forming.
At first, as shown in Figure 2, keep nipple the projection 19 of body 15 to insert and be fixed in the opening 26 of liquid through the plate body 25b of body 25.
Then the base end part 11b of nipple 11 is embedded nipple and keep in the large-diameter portion 15b of body 15, and then, keep body 15 to keep nipple 11 by nipple keeping frame 13 to embed in this large-diameter portion 15b.
In this case, preferably between large-diameter portion 15b that nipple keeps body 15 and maintenance frame 13, clip sealing member.In addition, be fixed in liquid and see through in the opening 26 of body 25 because nipple keeps the projection 19 of body 15 to insert, and the clava 25a that liquid sees through body 25 is connected on the inner face of nipple body 11a, liquid sees through body 25 and keeps body 15 and nipple 11 positioning and fixing by nipple.
Then, the female thread 18 of lid 17 is sticked in nipple and keeps on the external screw thread 16 of body 15, and lid 17 is enclosed within nipple and keeps on the cylindrical portion 15a of body 15.In this case, in lid 17, by bonding agent medicine container 20 is installed in advance, when cover upper cover 17 on the cylindrical portion 15a of nipple maintenance body 15, the thin film 21 of medicine container 20 is kept the projection 19 of body 15 to pierce through and breakage by nipple.
If thin film 21 breakages, then the liquid medicament (containing the xylitol composition) in the medicine container 20 shifts to nipple 11 1 sides through body 25 via liquid.
Suck nipple 11 if newborn child contains, then see through body 25 and enter in newborn child's the mouth, can seek the prevention of dental caries by the xylitol composition to the perforate 12 of medicament that nipple 11 1 sides shift from nipple body 11a by liquid.
Moreover, when the medicament in the medicine container 20 all consumes, keep body 15 to take off lid 17 and medicine container 20 from nipple, the new lid 17 with the medicine container 20 that is full of medicament in advance is installed in nipple and keeps on the body 15.
In addition, use nipple device 10 for a long time after, by decomposing each constituent part, can clean each constituent part (with reference to Fig. 2) with aforementioned opposite method.
As mentioned above, according to present embodiment, under the situation that the medicament in medicine container 20 is consumed, medicine container that only wearing or featuring stage armour is new 20 is installed in nipple with lid 17 and keeps on the body 15, just can be easily and carry out the additional of medicament simply.In addition, only depend on and decompose each component parts, just can easily carry out the cleaning of each component parts.
Next just describe with Fig. 4 and Fig. 5 according to the 2nd embodiment of nipple device of the present invention.Moreover, in the 2nd embodiment shown in Fig. 4 and Fig. 5, the part identical with the 1st embodiment shown in Fig. 1 to Fig. 3 given same numeral and omitted detailed explanation.
As shown in Figures 4 and 5, nipple device 10 has the nipple that contains the nipple 11 suck in the infant mouth, keeps nipple 11 and keeps body 15 and be fastened on nipple keeping lid 17 on the body 15.
In lid 17, be provided with thin film.And be filled with liquid credit thoroughbred horse in the zone of in lid 17, being told 30, for example added the liquid medicament of anticariogenic xylitol composition by thin film 21.In this case, the zone of being told by thin film 21 in the lid 17 30 constitutes medicine container.
In addition, when lid 17 was fastened on the nipple maintenance body 15, nipple described later kept end (damaged portion) 15d of the division wall 15c of body 15 to make thin film 21 breakages.
, nipple keeps body 15 to comprise cylindrical portion 15a and is located at the large diameter large-diameter portion 15b of the side of this cylindrical portion 15a, is provided with aforementioned division wall 15c at the opposite side of cylindrical portion 15a.
By this constitute the nipple formed keep body 15 within it portion have and nipple 11 in the connected spaces 33 that are communicated with, this connected space 33 is covered by above-mentioned division wall 15c.In addition, on division wall 15c, be provided with connected entrance 31, on the face of connected space 33 1 sides of dividing wall 15c, the check valve 32 that switching seals connected entrance 31 freely be installed.This check valve 32 flows into the medicament in the zone 30 in connected space 33, the medicament in the connected space 33 can not shift to zone 30 1 sides.
Next just describe by this effect that constitutes the present embodiment of forming.
At first, as shown in Figure 4, the base end part 1b of nipple 11 is inserted in the large-diameter portion 15b of nipple maintenance body 15, and then, keep body 15 maintenance nipples 11 by nipple keeping a frame 13 to embed among this large-diameter portion 15b.
Then, the female thread 18 of lid 17 is fastened on nipple and keeps on the external screw thread 16 of body 15, and lid 17 is inserted on the cylindrical portion 15a of nipple maintenance body 15.In this case, be full of medicament in advance in the zone of in lid 17, being divided 30 by thin film 21, in the time of on lid 17 being inserted in the cylindrical portion 15a that nipple keeps body 15, the thin film 21 in the lid 17 kept by nipple body 15 division wall 15c end 15d breakage.
If thin film 21 breakages, then the medicament in the zone 30 flows in the connected space 33 of nipple maintenance body 15 via connected entrance 31 and check valve 32, and the medicaments in the connected space 33 shift to nipple 11 1 sides then.
Suck nipple 11 if newborn child contains, then to the medicament that nipple 11 1 sides shift enters newborn child's mouth from perforate 12 in, can seek the prevention of dental caries by the xylitol composition.
Moreover, when the medicament in the zone 30 of lid 17 all consumes, keep body 15 to take off lid 17 from nipple, the new lid 17 that is full of medicament in advance is installed on nipple maintenance body 15.
In addition, use nipple device 10 for a long time after, by decomposing each constituent part, can clean each constituent part (with reference to Fig. 5) with aforementioned opposite method.
As mentioned above, according to present embodiment, under the situation that medicament is consumed, can be easily and carry out the adjunctive program of medicament simply, and can easily carry out the cleaning of each component parts.
Next just describe with Fig. 6 to Fig. 9 according to the 3rd embodiment of nipple device of the present invention.
As shown in Fig. 6 and Fig. 7, nipple device 10 has the nipple that contains the nipple 11 suck in the infant mouth, keeps nipple 11 and have a container resettlement section 43 that is communicated with nipple 11 1 sides and keeps body 15 and swing to be installed on the nipple maintenance body 15 freely and the lid 42 of covering container resettlement section 43.
Wherein, nipple 11 is hollow form, as described later, sends into and stores the liquid medicaments that are full of in the medicine container 45 in it, for example contains the medicament of the xylitol composition of the prevention of dental caries.In addition, on nipple 11, be provided with storing the perforate 12 of outwards supplying with usefulness in the medicament of inside.
Nipple keeps body 15 to comprise the flange 40 that keeps nipple 11 and is located at flange cover 41 on the flange 40, and container resettlement section 43 is located in the flange cover 41.
The container resettlement section 43 that is located on the flange cover 41 is top openings, and is accommodating the medicine container 45 that is filled with liquid medicament in this container resettlement section 43.In addition, be provided with on container resettlement section 43 to the side-prominent cylinder guider 44 of nipple 11 1, container resettlement section 43 is communicated with to nipple 11 1 sides via this cylinder guider 44.
, lid 42 is installed in the flange cover 41 that nipple keeps body 15 freely via swinging axle 42a swing, from covering container resettlement section, top 43.In addition, at the engaging fin 48 that is provided with on the inner face of lid 42 on the upper end that is fastened on cylinder guider 44.And covering by lid 42 under the situation of container resettlement section 43, engaging fin 48 inserts in the container resettlement sections 43 and is fastened on the upper end of cylinder guider 44.
In this case, the upper end of cylinder guider 44 has the taper that becomes taper downwards, and the front end 48a of engaging fin 48 has the taper that becomes taper downwards corresponding to the upper end of cylinder guider 44.Engaging fin 48 in addition preferably is made of flexible material.
In addition, liquid medicament is filled in the inside of medicine container 45, and mounting or dismounting are contained in the container resettlement section 43 freely.That is to say that medicine container 45 is as totally being made of flexible material, comprise the outlet 46 that constitutes by hard material on container body 45a that accommodates medicament and the bottom that is located at container body 45a.The outlet 46 of medicine container 45 forms external screw thread 46a on its outside, screw in external screw thread 46a by the female thread (not shown) that makes cylinder guider 44 and insert in the cylinder guider 44 that is fixed in nipple maintenance body 15.
Moreover, can on the outside of outlet 46, not form external screw thread yet, and outlet 46 is embedded in the cylinder guider 44.
In Fig. 6 and Fig. 7, at first take off the cover 47 on the outlet 46 that is screwed in medicine container 45 in use, medicine container 45 is contained in nipple keeps in the container resettlement section 43 of body 15.At this moment, the female thread by the external screw thread 46a of the outlet 46 of medicine container 45 is screwed in cylinder guider 45 can be firmly fixed at medicine container 45 in the container resettlement section 43.
Then upwards push the container body 45a that constitutes by flexible material of medicine container 45, the medicament in nipple 11 1 side supply container main body 45a via outlet 46 and cylinder guider 44.Then, take off medicine container 45, make lid 42 via swinging axle 42a swing, by lid 42 hermetic container resettlement sections 43 from container resettlement section 43.The engaging fin 48 that be located on the inner face of lid 42 this moment is sticked on the upper end of cylinder guider 44, fully the upper end of sealed cylindrical guider 44.
Because engaging fin 48 is as totally being formed by flexible material, so can be by the front end 48a that engages fin 48 upper end of sealed cylindrical guider 44 reliably.
Suck nipple 11 if newborn child contains, then the medicament in the nipple 11 enters in newborn child's the mouth from the perforate 12 of nipple 11, can seek the prevention of dental caries by the xylitol composition.
Next describe with regard to the variation of the embodiment shown in Fig. 6 and Fig. 7 with Fig. 8 and Fig. 9.Embodiment shown in Fig. 8 and Fig. 9 is that medicine container 45 is fixed on the container resettlement section 43.
In Fig. 8 and Fig. 9, the part identical with the embodiment shown in Fig. 6 and Fig. 7 given identical label and omitted detailed explanation.
As shown in Figure 8, the outlet 46 on medicine container 45 bottom that comprises the piped container body 45a that constitutes by flexible material of the Serpentis that is filled with medicament and be located at container body 45a.
In addition, keep the nipple of nipple 11 to keep body 15 to comprise flange 40 and be located at container resettlement section 43 on the flange 40.
Container resettlement section 43 becomes within it portion and accommodates medicine container 45, is provided with in the bottom of container resettlement section 43 to the side-prominent cylinder guider 44 of nipple 11 1.
And then container resettlement section 43 is top openings, and swing is installed with the lid 42 that covers resettlement section 43 freely on container resettlement section 43.And then be provided with the pushing portion 49 of the piped container body 45a of pushing Serpentis in the inside of lid 42.
In Fig. 8, medicine container 45 is contained in nipple and keeps in the container resettlement section 43 of body 15, and the outlet 46 of medicine container 45 is inserted in the cylinder guider 44 simultaneously.
At this moment, by on the outside of the outlet 46 of medicine container 35, forming external screw thread, and on the inner face of cylinder guider 44, form female thread, can screw in outlet 46 in the cylinder guiders 44 and medicine container 45 is firmly fixed at container resettlement section 43.
Then make lid 42 swings, by lid 42 covering container resettlement sections 43.At this moment, by the container body 45a of the pushing portion 49 pushing medicine containers 45 of lid 42, the medicament in the container body 45a is sent to nipple 11 1 sides via outlet 46 and cylinder guider 44.
Next, be described with regard to another variation of the present invention by Fig. 9.In the variation shown in Fig. 9, medicine container 45 comprises the outlet 46 on container body 45a that is filled with medicament and the bottom that is located at container body 45.At this moment, container body 45a does not become the coiled pipe shape, and has slim shape, is made of flexible material.
In Fig. 9, medicine container 4a is housed in nipple and keeps in the container resettlement section 43 of body 15.At this moment, on the outlet 46 of medicine container 45, form external screw thread, in cylinder guider 44, form female thread, outlet 46 is screwed in the cylinder guider 44.
Then make lid 42 swings, by lid 42 covering container resettlement sections 43.Container body 45a by pushing portion 49 pushing medicine containers 45.Medicament in the container body 45a can be sent to nipple 11 1 sides via outlet 46 and cylinder guider 44 whereby.
Next, just describe with Figure 10 to Figure 12 according to the 4th embodiment of nipple device of the present invention.
Embodiment shown in Figure 10 to Figure 12, containing virus in employing, to catch medicament that the medicament of constituent replaces containing the xylitol composition different on as liquid medicament this point, and the embodiment shown in other and Fig. 1 to Fig. 9 is roughly same.
That is to say, in the medicine container shown in Fig. 1 to Fig. 3 20, replace containing the medicament of xylitol composition and charge into containing viral medicament of catching constituent, in the zone 30 of the lid shown in Fig. 4 and Fig. 5 17, replacement contains the medicament of xylitol composition and charges into the medicament that contains virus seizure constituent.And then in the medicine container shown in Fig. 6 to Fig. 9 45, replacement contains the medicament of xylitol composition and charges into the medicament that contains virus seizure constituent.
Next catching constituent with regard to this virus describes in detail.Virus is caught constituent and is contained the water extract of Nidus collocaliae and/or the enzyme handled thing of Nidus collocaliae as effective ingredient.
Wherein, Nidus collocaliae is that esculent swift is made the saliva of oneself thread and does nest,, also uses as the food that has lung heat clearing, is good for the stomach, eliminates the phlegm, preserves youthful looks, nourishes medical functions such as strong from ancient times except edible as gourmet food in China.In addition,, contain protein and saccharic as its composition more, in addition, fatty hardly.
In the Nidus collocaliae of selling on the open market, though have natural (the cave Nidus collocaliae) in the cave, plucked with at (the domestic Nidus collocaliae) of indoor culture, the both can use.In addition, after cleaning, the fragment of collection Nidus collocaliae is bleached repeatedly and cleaned up to shaping person all kinds though remove dirt such as feather and birds droppings from the Nidus collocaliae of plucking, and preferably is used in the Nidus collocaliae that does not carry out over-drastic cleaning or bleaching in the pre-treatment.
Nidus collocaliae water extract of the present invention for example can obtain as following.Be ground into below the particle diameter 2mm, preferably in the Nidus collocaliae of the following size of 150 μ m, adding the water of 10～1000 times of amounts of its quality, under 1～100 ℃, leave standstill or stir extracted in 0.5～48 hour after, filter and obtain filtrate.This filtrate remains untouched, and perhaps suitably concentrates and makes concentrated solution, can be used as virus of the present invention and catches constituent.In addition, also can be these freeze-dried or spray drying and powdered.
In addition, the enzyme handled thing of Nidus collocaliae can by to the water of 10～1000 times of amounts in the Nidus collocaliae that is ground into above-mentioned same size, adding its quality or hot water, with above-mentioned extraction similarly after extract (solution before filtering), at the solution that under 60～130 ℃ aforementioned extract has been carried out after 5～30 minutes heat treated enzymes are handled, above-mentioned extract is carried out filtrate filtered, perhaps carry out enzyme and handle and obtain.
As above-mentioned enzyme, protease preferably for example generally can be used in combination the enzyme of using as food with one or more and sells on the market.Specifically, " pancreatinum F " (trade name can be shown for example, amano pharmaceutical system), " ア ロ ア one ゼ AP-10 " (trade name, YAKULT pharmaceutical industries system), " solvable carase " (trade name, YAKULT pharmaceutical industries system), " thermostability protease, サ モ ア one ゼ " (trade name, big and system of changing into) etc.
In addition, the enzyme treatment conditions limit especially, and the pH of solution is adjusted to the best pH of the enzyme of use, add enzyme in right amount, after reacting 0.5～24 hour under the optimum temperature of enzyme, carry out heat treated etc. and make enzyme deactivation just passable.The filtrate that filters this reactant liquor and obtain remains untouched or suitably concentrates and make concentrated solution, can be used as virus of the present invention and catches constituent.In addition, also can be these freeze-dried or spray drying and powdered.
The mean molecule quantity of above-mentioned enzyme handled thing preferably 500～200,000,2000～70,000 is better.
Virus of the present invention is caught constituent except resulting Nidus collocaliae water extract or its enzyme handled thing as mentioned above, can contain compositions such as functional food ingredients such as various sugars, lactobacillus, bacillus bifidus, polyphenol, oligosaccharide, protein, fatty acid, mineral, vitamin, dietary fiber, glucide, interfacial agent, antiseptic.
Though the form of viral agent for capturing of the present invention does not limit especially, preferably makes solution or pasty state agent.In addition, so virus is caught constituent composition stability height from food, also can be used as inhalant etc. and directly human body is used.
The content of the water extract of the Nidus collocaliae in the virus seizure constituent of the present invention and/or the enzyme handled thing of Nidus collocaliae is 0.1～10000 μ g/mL preferably, is 0.2～400 μ g/mL better.
Each sample shown in the modulomenter 1 is used for following test.
Table 1
| Sample | Grade | Processing method | Sialic acid content (total amount) | |
| 1 | Select quality | After the Protease Treatment (37 ℃, 16 hours), heating (90 ℃) inactivation.After the filtration, freeze-dried. | 7.6 quality % | 64.4 |
| 2 | Primes | After the Protease Treatment (37 ℃, 16 hours), heating (90 ℃) inactivation.After the filtration, freeze-dried. | 4.2 quality % | 67.8 quality % |
| 3 | Seconds | Boil after water stain, Protease Treatment is (37 ℃ again, 16 hours) after, heating (90 ℃) inactivation.After the filtration, freeze-dried. | 9.6 quality % | 46.0 quality % |
| 4 | Select quality | After the pulverizing, screening (150 μ m mesh are by product) does not have Protease Treatment | 5.0 quality % | - |
| 5 | Select quality | After the pulverizing, screening (150 μ m mesh are by product) does not have Protease Treatment | 9.5 quality % | - |
(1) infects neutralization test
By measuring from the activity of MDCK (Madian-Darby CanineKidney) the acid by dehydrating lactic enzyme (LDH) that cell monolayer discharged that has infected influenza virus, the damage degree of the cell membrane that mensuration people influenza virus causes is (with reference to C-T Guo, C-H Wong, TKajimoto, T Miura, Y Ida, L R Juneja, M J Kim, H Masuda, T Suzuki, and Y Suzuki.Synthetic sialylphosphatidyl-ethanolamine deriv atives bind to human influenza A virusesand inhibit viral infection.Glycoconjugate J., 1998,15 (11): 1099～1108).
That is to say, the influenza virus that contains about 100TCID50 (50% Tissue-CulutureInfectious Dose:50% TCID) (A/PR/8/34 (H1N1) or A/ like to know/2/68 (H3N2)), be inoculated in the mdck cell of going up monolayer culture at 96 hole titer plates (flat) with the EMEN culture medium (Eagles MinimumEssential Medium) of each sample shown in the table 1 (ultimate density 1～5000 μ g/mL), cultivated 5 hours down at 34.5 ℃.
After the cultivation, remove liquid, outstanding turbid in 100 these culture medium of μ L.And then, cultivated 20 hours down at 34.5 ℃, 12.5 μ L of resulting culture fluid are diluted to 4 times with 100mM tri hydrochloride buffer liquid (pH8.2), add reactant liquor (the 2mM NAD of 50 μ L, the diaphorase of 200m-unit/mL, the 190mM EINECS 212-761-8,0.78mM blue tetrazolium, 100mM tri hydrochloride buffer liquid (pH8.2)).Cultivation is after 10 minutes down at 37 ℃, and the 0.5M hydrochloric acid that adds 100 μ L stops reaction.Measure the absorbance (contrast 630nm) of 550nm and obtain the LDB activity.Moreover, adopt myosin (Fetuin) as positive control.Myosin is the composition that the cattle fetal blood is contained in clear, has in the influenza virus and activity is known.It the results are shown in Figure 10.
As shown in Figure 10 (A), (B), to the IC of people's influenza virus of sample 1 (A/PR/8/34 (H1N1) likes to know/2/68 (H3N2) with A/)
50Be 80 μ g/mL, find out with comparing to have 2～8 times strong obstruction activity as the obstruction activity of the myosin of positive control.On the other hand, sample 2 is found out people's influenza virus (A/PR/8/34/ (H1N1)) is had the obstruction activity roughly equal with myosin.
Moreover, with regard to above-mentioned each sample, use the NDCK cell monolayer, the EMEM culture medium of the Nidus collocaliae solution (initial concentration 5mg/mL) that contains each twice dilution was cultivated 25 hours down to the mdck cell interpolation of going up monolayer culture at 96 hole titer plates (flat) and at 37 ℃, the activity of the acid by dehydrating lactic enzyme (LDH) by measuring resulting culture fluid, when whether investigation has cytotoxicity, in all samples, mdck cell is not demonstrated cytotoxicity, find out safe situation.
(2) erythrocyte anti-coagulating action test
The PBS of each 25 dispensing μ L on each depressed portions of 96 hole titer plates (at the bottom of the U), the 1st row tested sample (sample 1,2) solution 25 μ L put into titer plate suck discharge several times with micropipet.25 μ L of the depressed portions of the 1st row are moved on to the 2nd row, suck discharge several times with micropipet.Carry out this operation equally to the 3rd row, the 4th row, make 2 times of dilution row.
On each depressed portions, after each dispensing contains the solution 25 μ L of the virus shown in the table 2, rock titer plate lentamente, placed 60 minutes down at 4 ℃ then.Then, each dispensing 0.5% (V/V) people erythrocyte suspension 50 μ L on each depressed portions, slowly rock titer plate, placed 60 minutes down at 4 ℃ then, again by sedimentation condition judgement agglutinative have or not of erythrocyte on the bottom of each depressed portions, calculate each sample, owing to producing the least concentration that anti-coagulating action occurs.It the results are shown in table 2.
Table 2
| Virus | Erythrocyte anti-coagulating action concentration (mg/L) | |
| Sample 1 | Sample 2 | |
| A/PR/8/34(H1N1) | 2.5 | 40 |
| A/ likes to know/2/68 (H3N2) | 20 | 640 |
| A/ Hong Kong/1/68 (H3N2) | 10 | 40 |
| A/ Memphis/1/71 (H3N2) | 20 | ＞2500 |
| A/ Memphis/102/72 (H3N2) | 10 | 20 |
| A/ Tokyo/6/73 (H3N2) | 5 | 40 |
| A/ Kumamoto/55/76 (H3N2) | 20 | 80 |
| A/ Texas/1/77 (H3N2) | 5 | 80 |
| A/ Pyrusussuriensis/2/77 (H3N2) | 2.5 | 40 |
| A/ Bangkok/1/79 (H3N2) | 2.5 | 20 |
| A/ duck/Alba/35/76 (H1N1) | 10 | 10 |
| A/ duck/Hong Kong/7/75 (H3N2) | 1.25 | 20 |
| A/ duck/Hong Kong/24/76 (H3N2) | 10 | 640 |
| A/ duck/Hokkaido/5/77 (H3N2) | 2.5 | 20 |
| A/ duck/Hokkaido/8/80 (H3N8) | 2.5 | 10 |
| A/ duck/Hong Kong/23/76 (H5N3) | 1.25 | 20 |
| A/ pig/Iowa/15/30 (H1N1) | 1.25 | 5 |
| A/ pig/Colorado/1/77 (H3N2) | 320 | ＞2500 |
| A/ pig/Hong Kong/126/82 (H3N2) | 1.25 | 40 |
As shown in table 2, sample 1 is found out the influenza virus (from people, fowl or the isolating virus of pig) of investigation, and the virus except A/ pig/Colorado/1/77 (H3N2) is shown erythrocyte anti-coagulating action activity with low-down concentration.On the other hand, sample 2 is found out the virus except A/ Memphis/1/71 and A/ pig/Colorado/1/77 (H3N2) is shown erythrocyte anti-coagulating action activity with low concentration.
According to above result, find out that the influenza virus of 1,2 pairs of wide width of cloth types of sample has adsorptivity.
(3) sialic acid molecule kind and the content that is contained in sample 1 and the sample 2
Influenza virus identification, clear in conjunction with containing sialic specific sugar chain.Therefore, with the sialic molecular species in the following method investigation Nidus collocaliae and content (with reference to Hara, S., Yamaguchi, M., Takemori, Y., Nakamura, M., Ohkura, Y.: by with the contrary d-phase liquid chromatography of fluorescence detection to the N-acetyl in human serum and urine and the mouse serum-and N-glycollyl nerve amines saccharic acid carry out high sensitivity measuring.The chromatography magazine, 377,111～119 (1980), Hara, S., Takemori, Y., Yamaguchi, M., Nakamura, M., Ohkura, Y.:N-acetyl-and the fluorescence HPLC (high performance liquid chromatography) method of N-glycollyl nerve amines saccharic acid and in human and animal's serum micrometering use surely.Analytical biochemistry, 164,138～146 (1987)).
That is to say, each sample in the 2M acetic acid of 20 μ L with 80 ℃, the heating 3 hours, after adding the sialic glucoside combination of water decomposition, adding adds fluorometric reagent (sodium bisulfate 15.7mg to water, 2 mercapto ethanol 350 μ L and diaminourea 4, add water 5mL modulation person among 5 methylenedioxybenzenes 2HCl (following DMB, the colleague's chemistry) 7.9mg) 20 μ L, in the dark with 50 ℃ of heating 2.5 hours.
In the middle of this reactant liquor, separate sialic fluorescence dielectric, detect with spectrofluorophotometer (trade name ' 650-10S ' Hitachi system) by HPLC with the COSMOSIL/COSMOGEL カ ラ system (trade name, NACALAI TESQUE corporate system) of 10 μ L.It the results are shown in Figure 11.
As shown in Figure 11, find out that sample 1 and sample 2 all contain sialic acid, N-acetyl neuraminic acid (NeuAc) is the main molecules kind.In addition, find out and also contain the few N-glycolyl neuraminic acid (NeuGc) of ratio.In addition, the N-acetyl neuraminic acid content (12.25%) of sample 1 is approximately higher 2 times than sample 2 (6.25%), and N-glycolyl neuraminic acid content is 0.41% in sample 1, is 0.09% in sample 2.
According to this result, the sialic acid that is contained in the sample 1,2 is very similar to people's sialic acid molecule kind, and hint is to contain these sialic protein, peptide or fat molecule and the bonded composition of influenza virus.
In addition, though comparing with sample 2, sample 1 can recognize high influenza virus in conjunction with active and infection obstruction activity, but because this fact and sample 1 come the sialic acid content height to be relative compared with sample 2, the sialic acid in the hint sample contains molecule and has anti-infection activity.
(4) with following method investigation influenza virus to the associativity by the isolating glycopeptide of SDS-acrylamide gel electrophoresis (SDS-PAGE) (with reference to Takashi Suzuki, Mikiko Tsukimoto, Masato Kobayashi, Akira Yamada, YoshihiroKawaoka, Robert G.Webster, Yasuo Suzuki: sialoglycoprotein and antiviral neuraminidase in the various animal blood slurrys in conjunction with influenza A virus.Common virology magazine, 75,1769～1774 (1994)).
That is to say, sample 1 that is dissolved in PBS or sample 2 (0.2mg) (are contained 2%SDS, 10% glycerol, 0.001% bromophenol blue, 0.0625M three buffer, pH6.8) dilution with the sample modulation with buffer with equal amounts of S DS-PAGE.Each sample was handled in boiling water bath 5 minutes, and under non-reduced, the SDS-polyacrylamide of the concentration by 10～20% (SDS-PSGE plate: trade name ' ET-1020L ', ア ト one corporate system) separates.
The glycopeptide that is launched into gel duplicates (2mA/cm switched on 30 minutes down) to polyvinylidene fluoride (PVDF) film (First Chemical Corp.'s system), with 5% Sanguis Bovis seu Bubali albumin (BSA)-PBS solution (0.2mL/cm), suppresses 15 hours with 4 ℃.After this pvdf membrane cleaned five times with PBS, be added in synthetic influenza virus-0.25%BSA-PBS suspension among the 2HAU,, under 4 ℃, stably vibrated 15 hours for fear of the influence of viral neuraminidase.Then, remove viral suspension, with PBS pvdf membrane is cleaned five times after, add influenza and emit antiviral antibody, 4 ℃ of vibrations 2 hours down.Remove antibody-solutions, with PBS this pvdf membrane is cleaned five times after, add the 0.25%BSA-PBS solution of ABC (peroxidase) the キ Star ト (trade name, Wei Keduo laboratory corporate system) of VECTASTAIN Kit, vibrated 2 hours down at 4 ℃.After with PBS this pvdf membrane being cleaned five times, be used in and sneak into colour developing liquid (the acetonitrile solution 200 μ L of 110mM-4-chloro-1-naphthols among 0.1M acetic acid (pH6.0) 10mL, 60mM N, the acetonitrile solution 200 μ L of N-diethyl-p-phenylenediamine-dihydrochloride, 31% hydrogenperoxide steam generator, 1 μ L three's mixture) the viral combination of investigation.It the results are shown in Figure 12.
As shown in Figure 12, can confirm sample 1 and sample 2 all with influenza virus (A/ like know/2/68 (H3N2) A/ Memphis/1/71 (H3N2)) bonded band (band among the figure shown in the arrow).On the other hand, owing to can't confirm to be incorporated into the band of virus in the control experiment (virus (-)) that other operations are handled identically not adding virus, so can think that above-mentioned band is the glycopeptide that can be incorporated into virus specifically.In addition, though the dye levels of the band that coomassie brilliant blue staining (CBB) (protein or peptide can dye) causes in sample 1,2 much at one, find out with virus associativity, sample 1 is than sample the last 2, its kind is also many.According to this result, just find out in sample 1, contain with the bonded sialic glycopeptide ratio of influenza virus abundant in sample 2.
Virus of the present invention is caught constituent, thus since since be main component stability height from the composition of food, in addition because the virus of planting type is had adsorptivity, so can be used as the infection mitigation agent utilization of virus.In addition, send in newborn child's the mouth from the nipple 11 of nipple device 10, can prevent newborn child's viral infection by this virus being caught constituent.
Claims (17)
1. a nipple device is characterized in that,
Have: nipple keeps the nipple of nipple to keep body, and is sticked in the lid on the nipple maintenance body;
Be provided with medicine container portion in lid, medicament is filled within it, and nipple one side is covered by thin film;
Keep being provided with the portion of breaking on the body at nipple, when lid is sticked on the nipple maintenance body, thin film is punctured.
2. the described nipple device of claim 1 is characterized in that,
Keep being provided with on the body liquid that in nipple, extends at nipple and see through body,
Nipple keeps the portion of breaking of body to be made of the projection of thrusting thin film.
3. the described nipple device of claim 1 is characterized in that, keeps being provided with external screw thread on the body at nipple, is provided with the female thread that engages with this external screw thread on lid.
4. the described nipple device of claim 2 is characterized in that, liquid sees through body and constitutes by the plate body on the thin film that is connected to medicine container portion and from the clava of this plate body to the extension of nipple one side.
5. the described nipple device of claim 4 is characterized in that, sees through on the plate body of body at liquid and is provided with opening, and it is side-prominent to medicine container portion one that projection is passed this opening from nipple one side.
6. the described nipple device of claim 1 is characterized in that, medicine container portion is made of the medicine container that is located in the lid.
7. the described nipple device of claim 1 is characterized in that, medicine container portion is by being constituted by the zone that thin film marked in the lid.
8. the described nipple device of claim 1 is characterized in that,
Nipple keep body have with nipple in the connected space that is communicated with,
This connected space is located at medicine container portion one side, and the division wall with connected entrance covers.
9. the described nipple device of claim 8 is characterized in that, nipple keeps the portion of breaking of body to be made of the end of dividing wall.
10. the described nipple device of claim 8 is characterized in that, is provided with the check valve that makes medicament keep body to flow into from medicine container portion to nipple on the opening of dividing wall.
11. a nipple device is characterized in that,
Have: nipple, the nipple that keeps nipple and have a container resettlement section that is communicated with nipple one side keeps body, and swing is installed in nipple freely and keeps on the body the also lid of covering container resettlement section,
Dispose medicine container in the container resettlement section, medicament is filled within it, and has opening in nipple one side.
12. the described nipple device of claim 11 is characterized in that,
On the container resettlement section, be provided with to the side-prominent cylinder guider of nipple one,
Medicine container has the outlet of inserting in this cylinder guider.
13. the described nipple device of claim 12 is characterized in that,
Medicine container can freely take off from the container resettlement section,
On lid, be provided with the engaging fin, engage with the cylinder guider of container resettlement section.
14. the described nipple device of claim 12 is characterized in that,
Medicine container is made of flexible material and is fixed in the container resettlement section,
On lid, be provided with the press section of extruding medicine container.
15. claim 1 or 11 described nipple devices is characterized in that medicament contains the xylitol composition.
16. claim 1 or 11 described nipple devices is characterized in that, medicament contains virus and catches constituent.
17. the described nipple device of claim 16 is characterized in that, virus is caught constituent and is contained the water extract of Nidus collocaliae and/or the enzyme handled thing of Nidus collocaliae as effective ingredient.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2003/006286 WO2004103257A1 (en) | 2003-05-20 | 2003-05-20 | Nipple device |
| JPPCT/JP03/06286 | 2003-05-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1791374A true CN1791374A (en) | 2006-06-21 |
| CN100418505C CN100418505C (en) | 2008-09-17 |
Family
ID=33463130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004800136970A Expired - Fee Related CN100418505C (en) | 2003-05-20 | 2004-04-20 | Nipple device |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1625843A4 (en) |
| JP (1) | JP4472635B2 (en) |
| KR (1) | KR101128968B1 (en) |
| CN (1) | CN100418505C (en) |
| AU (1) | AU2003234839A1 (en) |
| WO (2) | WO2004103257A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011009284A1 (en) * | 2009-07-22 | 2011-01-27 | Dongguan Kidsme Trading Company Limited | Feeding apparatus |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT506295B1 (en) * | 2008-07-23 | 2009-08-15 | Mam Babyartikel | SCHNULLER WITH A SUCKER |
| MX2021004948A (en) * | 2018-12-27 | 2021-07-21 | Vivolab Ab | Pacifier with fluid passageway and exchangeable housing. |
| WO2021256975A1 (en) | 2020-06-15 | 2021-12-23 | Vivolab Ab | Pacifier |
| SE544941C2 (en) * | 2020-06-15 | 2023-02-07 | Vivolab Ab | Pacifier comprising an aerosolization device |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA956606A (en) * | 1970-02-02 | 1974-10-22 | Stanley J. Koll | Infant feeding package |
| JPH06508Y2 (en) * | 1987-03-05 | 1994-01-05 | パシフイツクコンサルタンツ株式会社 | Design tile that is hard to crack and does not scatter |
| US5123915A (en) * | 1990-04-27 | 1992-06-23 | Miller Lawrence E | Medicated pacifier |
| JPH0423669U (en) * | 1990-06-19 | 1992-02-26 | ||
| GB2246555A (en) * | 1990-07-19 | 1992-02-05 | Christopher George | Packaging for medicine |
| CN2115113U (en) * | 1992-02-14 | 1992-09-09 | 任超忠 | Dual-purpose medicine-feeding device for babies |
| JPH065637U (en) * | 1992-06-30 | 1994-01-25 | 鴻明 李 | Medicine dispenser |
| GB2309966A (en) * | 1996-02-07 | 1997-08-13 | Harwill Ind Pty Ltd | Teat device for administering medicaments |
| JPH09226848A (en) * | 1996-02-22 | 1997-09-02 | Nissho Corp | Drink container for baby |
| WO1998025572A1 (en) * | 1996-12-11 | 1998-06-18 | Crowe D E | An infant pacifier - fluid administering unit |
| JP4233074B2 (en) * | 2000-04-24 | 2009-03-04 | ピジョン株式会社 | Artificial nipple |
| JP4023669B2 (en) * | 2001-10-23 | 2007-12-19 | 日本碍子株式会社 | Electrochemical equipment |
-
2003
- 2003-05-20 AU AU2003234839A patent/AU2003234839A1/en not_active Abandoned
- 2003-05-20 WO PCT/JP2003/006286 patent/WO2004103257A1/en active Application Filing
-
2004
- 2004-04-20 JP JP2005506314A patent/JP4472635B2/en not_active Expired - Lifetime
- 2004-04-20 EP EP04728413A patent/EP1625843A4/en not_active Withdrawn
- 2004-04-20 CN CNB2004800136970A patent/CN100418505C/en not_active Expired - Fee Related
- 2004-04-20 WO PCT/JP2004/005628 patent/WO2004103258A1/en active Application Filing
- 2004-04-20 KR KR1020057020898A patent/KR101128968B1/en not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011009284A1 (en) * | 2009-07-22 | 2011-01-27 | Dongguan Kidsme Trading Company Limited | Feeding apparatus |
| CN102724949A (en) * | 2009-07-22 | 2012-10-10 | 东莞亲亲我实业有限公司 | Feeding apparatus |
| CN102724949B (en) * | 2009-07-22 | 2015-09-23 | 东莞亲亲我实业有限公司 | Feeder |
| EA027883B1 (en) * | 2009-07-22 | 2017-09-29 | Дунгуань Кидзми Индастриал Лимитед | Feeding apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4472635B2 (en) | 2010-06-02 |
| WO2004103257A1 (en) | 2004-12-02 |
| KR101128968B1 (en) | 2012-03-27 |
| EP1625843A1 (en) | 2006-02-15 |
| JPWO2004103258A1 (en) | 2006-07-20 |
| WO2004103258A1 (en) | 2004-12-02 |
| AU2003234839A1 (en) | 2004-12-13 |
| CN100418505C (en) | 2008-09-17 |
| EP1625843A4 (en) | 2008-01-23 |
| KR20060010779A (en) | 2006-02-02 |
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