CN1784173A - Optical biopsy system with single use needle probe - Google Patents
Optical biopsy system with single use needle probe Download PDFInfo
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- CN1784173A CN1784173A CN 200480012076 CN200480012076A CN1784173A CN 1784173 A CN1784173 A CN 1784173A CN 200480012076 CN200480012076 CN 200480012076 CN 200480012076 A CN200480012076 A CN 200480012076A CN 1784173 A CN1784173 A CN 1784173A
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Abstract
A single use needle-like probe contains optical fibers to deliver and collect light at the distal tip of the needle-like probe. The single use needle-like probe may connect to a handpiece that may contain sensors to monitor how the probe is being used. Sensors within the handpiece may, e.g., include a force sensor and a position sensor that detect the depth of the probe in tissue. The handpiece may be connected through a cable to a control unit that may include light sources, optical detectors, control electronics and one or more microprocessors to analyze the data collected.
Description
The application requires to enjoy and submitted on March 17th, 2003, exercise question is the serial No.60/455 of the U.S. Provisional Patent Application of " optical biopsy system with disposable needle probe ", and 536 priority is incorporated this paper by reference into.
The application requires to enjoy and submitted on March 17th, 2004, exercise question for " optical biopsy system with disposable needle probe ", Docket No. is the priority of the U.S. Patent application series No.____ of BL-4NPROV, incorporate this paper by reference into, Luiz B.Da Silva is the applicant.
Background of invention
Invention field
The present invention relates to organizational diagnosis probe and the system of the optical measurement of using-system with accurate mensuration types of organization and state.
Description of related art
The open surgical B Bx that has 19,000 examples that the women is carried out weekly approximately in the U.S..Only find about 3000 routine cancers.Therefore, about 85% in these biopsies are unnecessary.This means owing to the uncertainty of cancerous issue in diagnosis mammary gland, have 16,000 women to carry out unnecessary open surgical B Bx weekly approximately in the U.S..
Because open surgical B Bx is an invasive and traumatic to the patient, so people] wish to avoid this inspection very much.In surgical biopsies, the position to be checked of abnormal structure will utilize thin hook-shaped criterion to come labelling.The surgeon is following criterion until the position of abnormal structure to be checked and excise suspicious region.Open surgical biopsies is a prevailing form in the biopsy, and the patient is invasive, poignant and wishes to avoid.Open surgical biopsies also may stay scar tissue, and this may make the diagnosis capability of mammogram in future thicken, thereby has brought serious obstacle to the patient.
Bioptic another form is big core diameter pin biopsy (No. 14 syringe needle).The biopsy of standard core diameter removes the tissue of 1mm * 17mm core diameter.Big core diameter pin biopsy is littler than the invasive of surgical biopsies, does not need the tissue removed but still remove some.
Bioptic another form is the biopsy of micropin suction-type.In this biopsy, a spot of cell of sucking-off is used for cytological analysis, and this method is a Wicresoft.But a shortcoming utilizing micropin to suck is a poor accuracy.This poor accuracy is caused by the little institute of sampling quantity, and this makes accurate cytodiagnosis become difficult.
It is longer that another shortcoming of conventional biopsy method is that the time that the sample tissue of excision needs is verified and analyzed to laboratory.Usually, may need to wait for the bimestrial approximately time from being checked through for the first time last diagnosis.Therefore, many women may experience intensive uneasiness when wait is made a definite diagnosis at last.
People have developed the physical features that the whole bag of tricks and device are measured tissue, to attempt to distinguish canceration and non-cancerous issue.For example, people's such as Strobl U.S. Patent No. 5,303,026 (Stroble patent) has been described a kind of equipment and method that is used for scattering medium such as biological tissue's spectrum analysis.More specifically, the Stroble patent has been described and a kind ofly has been used for producing in real time and collects from the equipment and the method that are applied with fluorescence, reflection, scattering and the absorption information of the sample tissue of multiple excitation wavelength.
People's such as Tiemann United States Patent (USP) 5,349,954 has also been described a kind of equipment that is used for characterizing tissues.This equipment also comprises hollow needle, is used for light is sent to desired tissue regions from monochromator by pin.Be provided with the light emitting diode with photosensitive surface in the axle of pin, this photosensitive surface is used to survey the backscattered light from tissue regions from axle outward.
People's such as Coppleson United States Patent (USP) 5,800,350 discloses a kind of equipment that is used for types of organization's identification.Particularly, this equipment comprises a kind of probe, and this probe designs is used for contact tissue and makes described tissue stand numerous different stimulations as electricity, light, heat, sound, magnetic field, and surveys the various physical responses to stimulating.This equipment also comprises the various responses of combined treatment so that with the processor of tissue typing.This processing and utilizing offers types of organization's indication (for example normally, canceration early stage/canceration or the unknown) of device operator and carries out in real time.
People's such as people's such as Mah United States Patent (USP) 6,109,270 and Hular U.S. Patent application series No.09/947,171 disclose multimodality (multimodality) equipment that is used for tissue characterization.Though the multimodality that people such as people such as Mah and Hular describe probe can provide possible more high precision (for example susceptiveness and specificity), the production of disposable multimodality probe is relatively more expensive.
Consider some limitation of existing biopsy technology, it is cheap, convenient and the disposable probe of types of organization and state real-time analysis can be provided reliably that people need.The present invention has satisfied this needs.
Summary of the invention
An object of the present invention is to provide and a kind ofly use accurately to measure the method and system of organism optical feature in the wave-length coverage (being generally 300nm-1000nm) of broad for the doctor.
It is the cancerous tissue or the system of normal structure for surgeon's use with definite suspicious damage that another object of the present invention provides a kind of.
Another object of the present invention provides a kind of for low-cost disposable probe and the system of surgeon's use with quick diagnosis breast carcinoma.
An object of the present invention is to provide and a kind ofly use accurately to measure the method and system of the optical signature of tissue in the wave-length coverage of broad for the doctor.
It is the cancerous tissue or the system of normal structure for surgeon's use with definite suspicious damage that another object of the present invention provides a kind of.
Embodiments more of the present invention comprise disposable needle probe, and this probe comprises the fiber optics that is used in transmission of needle probe far-end and gathered light.This disposable needle probe can be connected with the handle that comprises pick off, and described handle is used for the monitoring probe and how works.For example, the pick off in the handle can comprise force transducer and the position sensor of surveying the probe in tissue degree of depth.Handle can be connected with control unit by cable, and described control unit can comprise light source, photo-detector, control electronic equipment and be used to analyze one or more microprocessors of collected data.
In another embodiment, the inner core of needle probe contains along the electric conductor of external metallization sheath, and this electric conductor comprises and is used in a wider frequency (as 1KHz-1MHz) detecting the electrode pair of organizing electrical characteristics.The electrical characteristics that software analysis in the control electronic equipment is measured are also determined the type of tissue and possible structural state.The type and the state that utilize electrical characteristics to differentiate tissue are put down in writing in a large amount of documents; We can obtain comprehensively understanding a: C.Gabriel in incorporating following a series of documents of this paper by reference into, S.Gabriel, E.Corthout, Thedielectric properties of biological tissues:I, Phys.Med.Biol.41,2231; S.Gabriel, R.W.Lau and C.Gabriel:The dielectric properties of biological tissues:II.Measurements in thefrequency range 10Hz to 20GHz, Phys.Med.Biol.41,2251 (1996); S.Gabriel, R.W.Lauand C.Gabriel:The dielectric properties of biological tissues:III.Parametric models for thedielectric spectrum of tissues, Phys.Med.Biol.41,2271 (1996).
In normal utilization, the doctor uses new sterilized probe and it is connected to handle.Then system be activated and light from the probe far-end go out.Then the doctor inserts this probe tissue and handles it until the suspicious lesions place.During whole insertion, systematic survey optical properties of tissue, these optical characteristics can be analyzed subsequently to determine the type and the state of tissue.
Can regulate probe-handle adapter, only making pops one's head in is connected and therefore aims at whole optical fiber on an orientation.In one embodiment, the optical fiber in the handle closes on probe and is connected (proximity coupled).In alternative embodiment, handle contains connection from handle to probe or from popping one's head in to the optical lens of the light of handle.
Control unit contains for example white light source, is used to measure the absorption and the scattering properties of tissue.Laser instrument can be set with excite tissue fluorescence in control unit.Grating spectrometer and filtered detectors can be set to measure scattered light and fluorescent emission in control unit.Each provenance and detector can be used in the control unit, we can be from incorporating " Tissue Optics:Applications in Medical Diagnostics and Therapy " SPIE MS102 of this paper into by reference, Editor Valery V.Tuchin is comprehensively understood.
Handle can comprise measuring and being applied to probe and going up pick off with the power of piercing tissue.System can utilize this more stiff than normal structure in many cases damage in information location.Particularly for feminine care pads.Handle can also comprise the position sensor that detects the probe in tissue degree of depth.In one embodiment, position sensor is connected to slidably sheath, and this is slidably on the coaxial disposable use needle-like part that is placed in probe of sheath.
In another variant of the present invention, thereby reduce from the diffusing veiling glare that connects between the fiber with reflective coating coating optic fibre dimension.Aluminized coating is a kind of suitable coating compounds.
Thereby the diffusing veiling glare that another variant of the present invention connects between reducing from fiber at use light-absorbing polymers between the fiber optics.
Another variant of the present invention comprises aforesaid probe, and wherein this probe also comprises the memorizer of the useful information that can store relevant probe.
Another variant of the present invention comprises handle and contains the cable of reference optical fiber.Described reference optical fiber slave controller extends, and is connected to handle by flexible cable, and enters in the handle.Described reference optical fiber has far-end and far-end comprises the reflectance coating that is used for reflection ray.
Another variant of the present invention comprises aforesaid probe, and wherein this probe comprises that also the single-mode optics fiber is to implement interference of light range reflection (OCDR).
Another variant of the present invention comprises aforesaid probe, and wherein this probe is sharp.In another variant, to cut and to polish the far-end of probe less than the angle of 70 degree, the angle of preferred 30-70 degree.
Another variant of the present invention comprises the probe with numerous fibers and electric conductor.This variant feature also is to have the slidably sheath on the coaxial disposable use needle-like part that is placed in probe.This sheath can be withdrawn from far-end when probe inserts in the tissue.This variant can also comprise position sensor in handle, this pick off is set up is used to read the position of sheath with respect to distal probe.
Another variant of the present invention comprises the method that is used to discern tissue, and this method comprises aforesaid any one probe of artificial insertion.
Another variant of the present invention is to organize detection system, and this detection system comprises the disposable use needle probe with numerous fiber optics.This system also comprises having the integrated power and the handle of position sensor, and cable is connected to and sets up the control unit that is used for sending and collecting by numerous fiber optics light.
Others of the present invention and feature part are in the following description set forth, and others and feature partly will become apparent when reading hereinafter to those skilled in the art, or understand by implementing the present invention.
The accompanying drawing summary
The accompanying drawing of incorporating into and constituting a present disclosure part has been set forth embodiment of the present invention, and and description come together to explain principle of the present invention.
Fig. 1 illustrates the primary clustering of an embodiment of diagnostic system.
Figure 2 shows that detailed cross-section by disposable needle probe part center.
Figure 3 shows that the various fiber optic configurations that can be attached among the disposable needle probe.
Figure 4 shows that the detailed viewgraph of cross-section that passes handle.
Figure 5 shows that the detailed viewgraph of cross-section of another embodiment of passing handle.
Figure 6 shows that the measure spectrum of two kinds of histological types.
The specific embodiment
Fig. 1 has illustrated primary clustering of the present invention.Disposable needle probe 10 is connected to handle 20, and handle 20 links to each other with electronic control unit 40 by cable 30.This control unit comprises input equipment 50 (for example keyboard) and provides for the doctor and near the 10 most advanced and sophisticated display 60 of organizing relevant information of popping one's head in.Probe 10 with integrated optical fiber dimension launch near distal tip and is collected light, utilizes electronic control unit 40 to measure and analyze these light, thus definite type and state of organizing.Cable 30 comprises fiber optics and electric wire.
Figure 2 shows that detailed cross-section by 10 centers of popping one's head in.Probe 10 comprises outer metal sheath 100, and sheath 100 is bonding with the inner core 110 that comprises fiber optics 120.In one embodiment, probe contains numerous multimode fibers 120.In optional embodiment, probe contains numerous multimodes and single-mode optics fiber.Optionally electric conductor 125 also can be integrated in the inner core 110.When with outer metal sheath 100 in conjunction with the time, electric conductor 125 can be used for measuring the electrical characteristics of tissue.
Slide sheath 130 and be used to measure the degree of depth of probe in tissue.When probe inserts in the tissue, slide sheath 130 and partly slide up and down along the needle-like of popping one's head in.When connecting the near surperficial 135 time of sheath, can make it to contact with position sensor in the handle 20.Utilize retaining ring 140 to connect probe 10 and handle 20.Locating wedge (alignment key) thus 145 guarantee to pop one's head in and 10 between fiber optics, realize high coupling efficiency with handle 20 correct aiming at.Polished surface 150 and in one embodiment surface 150 directly and the optical surfaces in the handle contact.Outer metal sheath 100 is similar to standard medical needles, utilizes technology manufacturing well known in the art.Inner core 110 is made (for example polyurethane, polyethylene, glass, pottery) by biocompatible materials.The glue of available biocompatibility or epoxy resin are bonded together fiber optics 120 inner cores 110 and metal sheath 100.
Fig. 3 A-3E is depicted as the distal tip of the probe 10 that is used for various fiber orientation.Metal sheath 100 and inner core 110 outside the simplest structure of representing in Fig. 3 A comprises with two embedded multimode fibers.Fiber E is used to launch light, and the second fiber C collects the scattered light of being launched by the first fiber E at first.Fig. 3 B-3D is depicted as the structure with a plurality of collection fiber C and fluorescent fiber F, and light can be launched and collect to this structure simultaneously.Though show among the figure that all fibers have identical diameter, also can use size different fiber mutually.One in the fiber optics also can be the single mode fibre that is used to implement interference of light range reflection.In an alternate embodiment, Fig. 3 E, one of them fiber optics is substituted by electric conductor 200, is used to measure the electrical characteristics of tissue.Fig. 3 F represents that another substitutes and executes scheme that wherein electric conductor 200 and numerous fiber optics (C, E, F) are integrated in the probe with a dosed pack orientation.Electric conductor 200 can be single conductor, coaxial cable or multiplex conductor.
Figure 4 shows that handle 20 viewgraph of cross-section, showed key component among the figure.The stiff shaft 540 that shell 500 surrounds force transducer 510, position sensor 520, electron plate 530 and has integrated optical fiber dimension 545.Wedge 560 on axle probe 10 wedge groove 145 (see figure 2)s of combining closely, thus make fiber optics 120 and electric conductor 125 accurate aligning and being connected respectively in fiber optics 545 and electric conductor 555 and the probe 10 in the handle 20.The most advanced and sophisticated surface 550 of polishing butt joint is to improve handle 20 and the optical coupling between 10 of popping one's head in.In one embodiment, with the most advanced and sophisticated surface 550 of certain angle (as 8 degree) polishing butt joint and detecting head surface 150 to reduce back reflection.Force transducer 510 is measured the power that is applied to axle 540 far-ends.The force transducer (for example deformeter, tactile sensor, piezoelectric force transducer) that much can be integrated among the handle is arranged.Position sensor 520 is measured the position of sliding ring 525, and this slides ring and is driven by the sheath 130 that slides that is integrated among the probe 10.With slide ring 525 springs that are connected 522 and keep to slide and encircle 525 and slide contact between the sheath 130.The position sensor (for example potentiometric sensor, optical pickocff, capacitance sensor) that much can be integrated among the handle is arranged.Can in Jacob Fraden " Handbook of ModernSensors:physics, designs, and applications " second edition, find the description of suitable pick off, incorporate this paper by reference into.Electron plate 530 is regulated the signal of force transducers 510 and position sensor 520 and by being integrated in line 535 among the cable 30 with they transmission.In one embodiment, electron plate 530 comprises analog-digital converter and transmits measurement result with the form of numerical value.
Figure 5 shows that the viewgraph of cross-section of another kind of handle 20, there is shown key component.In this embodiment, be integrated in GRIN Lens (grin lens) 600 among the Handle axis 540 with handle fiber optics 545 and the optical coupling between 10 fiber optics 120 of popping one's head in.When handle 20 is connected with probe 10, the air gap between GRIN Lens and probe fiber optics will reduce the risk of damage optical surface when connecting.
Figure 6 shows that the measure spectrum of the mammary gland tissue of normal and canceration.Utilization has an emission fiber and a needle probe of collecting fiber obtains data.Absorption feature between 520nm and the 600nm is by due to the blood absorption.
The version that the present invention uses is very extensive.For example, the present invention can be used for detecting the cancerous issue in the mammary gland.Probe of the present invention also can be used for characterizing the unusual of other type of finding in other position of health.As mentioned above, probe of the present invention can be used in vivo, and perhaps, this probe can be at the external discriminating tissue that is used for.Preferably, probe setting of the present invention is used for measuring in real time and continuously the feature of tissue when probe tip inserts in the sample tissue.Thereby the processed immediately quick diagnosis of signal, discriminating or characterizing tissues from a plurality of pick offs of popping one's head in.
Device of the present invention also can use together in conjunction with other medical apparatus and instruments.For example, can be by the insertion of will popping one's head in of intubate or other tubular element that is used for medical procedure.
The institute of disclosed all functions parts and/or disclosed any means or operation in steps can combination in any in this description (comprising any appended claims, summary and accompanying drawing), unless at least some functional parts and/or step are repelled mutually in combination.In this description (comprising any appended claims, summary and accompanying drawing), each disclosed functional part can by other be used for identical, quite or the functional part of similar purpose replace, unless special explanation is arranged in addition.Therefore, unless special explanation is arranged in addition, disclosed each functional part only is an example that belongs to together in quite a series of or the identity function parts.The present invention is not limited to the details of previous embodiments.The present invention can expand the combination of any novelty of of any novelty of being extended down to disclosed functional part in this description (comprising any appended claims, summary and accompanying drawing) or functional part, perhaps expands or the combination of any one novelty of any novelty of the step that is extended down to disclosed any means of this description (comprising any appended claims, summary and accompanying drawing) or operation.
Claims (1)
1. diagnostic system comprises:
Handle and control system; With
Be used for determining the device of types of organization and state, wherein said device and described handle can be operatively connected.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45553603P | 2003-03-17 | 2003-03-17 | |
| US60/455,536 | 2003-03-17 | ||
| US10/803,574 | 2004-03-17 |
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| Publication Number | Publication Date |
|---|---|
| CN1784173A true CN1784173A (en) | 2006-06-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200480012076 Pending CN1784173A (en) | 2003-03-17 | 2004-03-17 | Optical biopsy system with single use needle probe |
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| CN (1) | CN1784173A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102215741A (en) * | 2008-11-19 | 2011-10-12 | 皇家飞利浦电子股份有限公司 | Needle with optical fibers |
| CN102215742A (en) * | 2008-11-19 | 2011-10-12 | 皇家飞利浦电子股份有限公司 | Needle with integrated fibers |
| CN102458229A (en) * | 2009-06-10 | 2012-05-16 | 皇家飞利浦电子股份有限公司 | Algorithm for photonic needle console |
| CN104219998A (en) * | 2012-03-30 | 2014-12-17 | 皇家飞利浦有限公司 | Medical needle |
-
2004
- 2004-03-17 CN CN 200480012076 patent/CN1784173A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102215741A (en) * | 2008-11-19 | 2011-10-12 | 皇家飞利浦电子股份有限公司 | Needle with optical fibers |
| CN102215742A (en) * | 2008-11-19 | 2011-10-12 | 皇家飞利浦电子股份有限公司 | Needle with integrated fibers |
| CN102215741B (en) * | 2008-11-19 | 2014-07-23 | 皇家飞利浦电子股份有限公司 | Needle with optical fibers |
| US11039750B2 (en) | 2008-11-19 | 2021-06-22 | Koninklijke Philips N.V. | Needle with optical fibers |
| CN102458229A (en) * | 2009-06-10 | 2012-05-16 | 皇家飞利浦电子股份有限公司 | Algorithm for photonic needle console |
| CN102458229B (en) * | 2009-06-10 | 2015-07-22 | 皇家飞利浦电子股份有限公司 | Algorithm for photonic needle console |
| CN104219998A (en) * | 2012-03-30 | 2014-12-17 | 皇家飞利浦有限公司 | Medical needle |
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