CN1777804A - Optical inspection device - Google Patents
Optical inspection device Download PDFInfo
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- CN1777804A CN1777804A CNA2004800108843A CN200480010884A CN1777804A CN 1777804 A CN1777804 A CN 1777804A CN A2004800108843 A CNA2004800108843 A CN A2004800108843A CN 200480010884 A CN200480010884 A CN 200480010884A CN 1777804 A CN1777804 A CN 1777804A
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- light
- stopple coupon
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention relates to an optical inspection device, which is used for checking whether the sample put in a sampling tube generates the optical change check subjects of a white stain, a white precipitation or fluorescence and so on. The device comprises a reaction block which is provided with more than one arrangement holes in the erect arrangement sampling tubes; a lighting unit of the light which is used for lighting and checking the sampling tube through a through-hole for checking formed on the side of the reaction block and a through-hole formed at the bottom; a video camera which is used for photographing each sampling tube through the through-holes; an arithmetical process device is used for checking the chemical reaction in the sampling tube according to the distribution of the brightness and the chromaticity of the image data shot by the video camera.
Description
Technical field
The present invention relates to whether the sample inspection of putting into stopple coupon is had the optical detection device of the inspection object of optical variations such as producing gonorrhoea white precipitate or fluorescence.
Background technology
In biology, medical science pharmacy, field of food etc., expect simple and easy, rapid, accurate, cheap gene amplifying method, as the new gene amplifying method that can adapt to such requirement, the LAMP method receives publicity in recent years.
It is high that this LAMP method is not only amplified efficient, and when in stopple coupon gene (DNA) elongation when synthetic, from pyrophosphate ion and a large amount of magnesium pyrophosphates that generate as accessory substance of the combination of the magnesium ion the reaction solution that matrix (dNTPs) is dissociated and, in stopple coupon, observe the gonorrhoea white precipitate.
On the other hand, under the situation of sample script muddiness, because can not observe the gonorrhoea white precipitate, so if inject and the gene interaction that is exaggerated and produce the fluorescent material of fluorescence, then by can in stopple coupon, observing fluorescence at irradiation exciting light on the sample.
But, can discern gene simply and whether be exaggerated by observing this gonorrhoea white precipitate or fluorescence, that is, whether the special genes that detect (inspection object) exists.
Fig. 8 shows that carrying out along with reaction detects the figure because of the major part of the pick-up unit of the degree of the gonorrhoea white precipitate that has or not the sample that produces that amplifies in such LAMP method in real time.
This optical detection apparatus 31 is formed on a plurality of aligned apertures 34 of the stopple coupon 33 on the reaction block 32 in arrangement ... go up separately, connecting formation orthogonally with each aligned apertures 34 observes with through hole 35 ... observing with configuration on the optical axis of through hole 35 to the light-emitting component 36 of stopple coupon 33 irradiating and detecting light with detect the photo detector 37 of the detection light that has seen through stopple coupon 33 along seeing through each.
If adopt such structure, then at stopple coupon 33 ... in put into each sample and be arranged in reaction block 32, when detecting the light that sees through stopple coupon 33 from light-emitting component 36 irradiations with photo detector 37 on one side, under the temperature conditions of regulation, make under the situation of its reaction on one side, for having carried out the script that gene amplifies, make through light intensity because of producing the gonorrhoea white precipitate and to descend, so change according to this light quantity, can detect having or not of gonorrhoea white precipitate, if produce the gonorrhoea white precipitate, just can be judged as the detected object thing and exist.
But the intensity variation that detects in photo detector 37 not only comes from the gonorrhoea white precipitate of sample, and considers the change of optical property of light-emitting component 36 and photo detector 37.
Promptly, if the light of light-emitting component 36 descends in the reaction, perhaps the output characteristics of photo detector 37 changes, although then sample is in the gonorrhoea white precipitate and also may be judged as and amplifies insufficiently by mistake, also might not judge disconnected the amplification by accident and finishes although the gonorrhoea white precipitate perhaps occurs.
Particularly, be subjected to its Temperature Influence, the possibility height of the changes in optical properties of photo detector 36 and photo detector 37 because reaction block 32 is heated.
Therefore, the light emitting diode that not only uses the band light to monitor as light-emitting component 36 was maintained the irradiation light quantity necessarily in the past, and for the influence of the heat of getting rid of reaction block 32, also light-emitting component 36 and photo detector 37 are left reaction block 32 configurations, in view of the above, being suppressed at Min. by thermogenetic change of optical property.
But, under the situation of leaving reaction block 32 configuration light-emitting components 36 and photo detector 37, in the reaction block 32 that is formed with the aligned apertures 34 about 8, because each 8 to light-emitting component 36 and photo detector 37 add up to 16 light-emitting components need carry out the optical axis contraposition, so be created in the problem that its optical axis contraposition of assembling stage of device bothers very much.
In addition, though make light-emitting component 36 and photo detector 37 leave reaction block 32 more, more little to the influence of the heat of each element 36,37, owing to be subjected to the influence of outside light easily, so also exist the trouble that must form the darkroom that reaction block 32 is set.
And then, measure turbidity because see through light intensity with 37 bases of photo detector, so, for example fuzzy in the stopple coupon 33 because of other external cause, formed bubble, then measure incorrect.
And, because that these produce in reaction is many, so even the optical characteristics of each element 36,37 is stable, in addition, also can to produce mensuration in the darkroom incorrect even reaction block 32 is arranged on.
Even above-mentioned each problem under the situation about having or not that will check object with fluoroscopy too.
Summary of the invention
Existence in view of the above problems, technical task of the present invention is, change with the light quantity of checking light, it doesn't matter for the fuzzy or bubble in the stopple coupon, can correctly detect the gonorrhoea white precipitate of reaction generation or the having or not of fluorescence of following sample, and, owing to do not need to carry out the correct optical axis contraposition of each optical element, can also carry out assembly operation simply.
The present invention is the optical detection device that has or not to the inspection object of the optical variation of the sample inspection generation gonorrhoea white precipitate of putting into stopple coupon or fluorescence etc., it is characterized in that, comprising: be formed with the reaction block of placing a plurality of aligned apertures of arranging stopple coupon; By the observation on the side that is formed on above-mentioned reaction block with through hole or be formed on through hole on the bottom surface, to the luminescence unit of above-mentioned each stopple coupon examination light; The video camera of with through hole each stopple coupon being made a video recording by above-mentioned observation; Luminance Distribution or colourity according to the view data of making a video recording with above-mentioned video camera distribute, and are determined at the arithmetic processing apparatus of the optical variation that produces in the stopple coupon.
If adopt optical detection apparatus of the present invention, then, can make a video recording simultaneously because of the optical variation that in each sample, produces of gonorrhoea white precipitate or fluorescence generation by enough cameras by checking light to the stopple coupon internal radiation.
For example, when using transparent sample, to adopt the LAMP method to judge under the situation about having or not of gene amplification by turbidity per sample, in the sample that does not carry out the gene amplification is transparent, because light not scattering in stopple coupon from the below irradiation, so it is dark to appear before one's eyes when making a video recording almost not from the light quantity of observation with the through hole leakage, thereby with video camera.
In addition, amplify upgrading as fruit gene, sample produces the gonorrhoea white precipitate, and then because produce scattering from the light of below irradiation in stopple coupon, so this scattered light leaks from observing with through hole, thereby it is bright to appear before one's eyes when making a video recording with video camera.
At this moment, in video camera because can take whole stopple coupons simultaneously, thus by specific with observe with the zone in the corresponding image in the position of through hole, can detect having or not of gonorrhoea to each zone, can not judge easily which sample produces gonorrhoea.
In addition, the data that Luminance Distribution that reads from the view data with each stopple coupon of video camera shooting or colourity distribute are not only numerical value, and as the position on the image of gonorrhoea part as the XY coordinate, the three-dimensional information identification of brightness as the Z coordinate.
Thereby, even shine the light quantity of each stopple coupon some variations are arranged, suitably select threshold value and standardization by implementing Flame Image Process, can get rid of because of light quantity changes the influence that causes, can correctly detect the situation of carrying out of gonorrhoea white precipitate.
As mentioned above,, also can correctly detect turbidity, in addition,, then also not need this optical axis contraposition if light-emitting component and reaction block are mounted to one even change because of light-emitting component is mounted to the light quantity that influences that one is heated at the bottom of aligned apertures and reaction block.
And video camera not only is configured in the position that full stopple coupon comes into view, and because only sees whether this image just can extremely easily confirm to be provided with the position suitable, so the correct optical axis contraposition of camera does not need, the assembling of device is oversimplified.
Equally, when using opaque sample, fluorescence adopts the LAMP method to judge under the situation about having or not of gene amplification per sample, and the fluorescent material of the gene that makes and be exaggerated (nucleic acid) interaction expression fluorescence reaction is sneaked in the sample.
Because amplifying to produce in carrying out at gene interacts, so even the irradiation exciting light does not show fluorescence yet, thereby appear before one's eyes secretly when make a video recording with video camera.
In addition, because if gene amplifies gene (nucleic acid) and fluorescent material interaction that upgrading then is exaggerated, thus when the irradiation exciting light, send fluorescence, thereby it is bright to appear before one's eyes when making a video recording with video camera.
At this moment, in video camera, because can make a video recording whole stopple coupons simultaneously, so can judge easily in which sample and produce fluorescence.In addition, the data that Luminance Distribution that reads from view data or colourity distribute because conduct discern with above-mentioned the same three-dimensional information, even some variations are arranged so shine the light quantity of each stopple coupon, also can get rid of because of light quantity changes the influence that produces, can correctly detect the situation of carrying out of fluorescence reaction.
And, also no longer needing the correct optical axis contraposition of any camera, the assembling of device is simplified this point too.
Description of drawings
Fig. 1 is the basic comprising figure of expression optical detection device of the present invention.
Fig. 2 is all pie graphs.
Fig. 3 is the key diagram of the surveyed area of presentation video data.
Fig. 4 is that the key diagram that reacts the image change of carrying out is followed in expression.
Fig. 5 is the curve map of presentation video result.
Fig. 6 is the curve map of presentation video result.
Fig. 7 is the major part of another embodiment of expression optical detection device.
Fig. 8 represents the key diagram that in the past installed.
Embodiment
Embodiment with reference to description of drawings the best of the present invention.
This optical detection device 1 disposes in shell 3: horizontal row form to settle arranges stopple coupon 2 ... a plurality of aligned apertures 4 ... 2 reaction block 5R, 5L; To each reaction block 5R, 5L make a video recording 2 video camera 6R, 6L of above-mentioned stopple coupon 2, and possess according to the arithmetic processing apparatus 7 that changes (optical variation) in each stopple coupon with the Luminance Distribution of the view data of above-mentioned video camera 6R, 6L shooting or turbidity that the colourity measure of spread produces.
And luminescence unit is not limited to the light-emitting component 8 of LED etc., can use element arbitrarily, and the light ejecting end of configuration optical fiber also can.
In addition, on the side of reaction block 5R, 5L, penetrate be provided for from the camera lens of video camera 6R, 6L to the observation of each stopple coupon 2 of emission line shooting of each stopple coupon 2 with through hole 9.
And, if forming with through hole 9, observation do not block the light path to stopple coupon 2 from video camera 6R, 6L, then its shape is arbitrarily, for example, also can be the situation that forms the slit of horizontal direction on the side of reaction block 5R, 5L.
Be transfused to arithmetic processing apparatus 7 with the view data of taking video camera 6R, 6L shooting, to each sample measurement turbidity.
In arithmetic processing apparatus 7, as shown in Figure 3, in view data G, set and observe the surveyed area A that uses through hole 9 camera shooting and sampling pipes 2 by each
1～A
8, according to each surveyed area A
1～A
8Data measure turbidity separately.
When adopting the LAMP method to carry out under the situation that gene amplifies, if follow amplifying gene then producing magnesium pyrophosphate of example reaction, along with its quantum of output gonorrhoea aggravation.
Fig. 4 (a)～(d) expression is for replacing magnesium pyrophosphate, and the diffusion polystyrene particle is produced the sample of gonorrhoea state in pure water, by concentration OD=0, and the key diagram of 0.02,0.2,0.4 these 4 kinds of image change that cause.
And then concentration uses ultra-violet and visible spectrophotometer to measure.
Under the situation of concentration OD=0, shown in Fig. 4 (a), be trapped in the interior same dark of sample of the bottom of stopple coupon 2, thereby use through hole 9 observed view data dark too from observing.
Under the situation of concentration OD=0.02, produce a little gonorrhoeas a little, shown in Fig. 4 (b), because the light of light-emitting component 8 produces scattering a little in sample, so observe scattering of light slightly along the center line of stopple coupon 2, this part is shinny slightly.
Under the situation of concentration OD=0.2, gonorrhoea quite develops, and shown in Fig. 4 (c), the light of light-emitting component 8 produces scattering in sample, the also chap of observing along the center line of stopple coupon 2 of hi-lite.
Under the situation of concentration OD=0.4, all gonorrhoeaizations of sample, shown in Fig. 4 (d), the hi-lite of middle body spreads to integral body.
In view of the above, for example obtain each surveyed area A by Flame Image Process
1～A
8Brightness distribution data, if 50% brightness of the maximum brightness in each image as threshold value, extract the shape of the part higher out than its brightness, then its shape changes as Fig. 5 (a)～(d).
At this, if the area S of this shape is defined as turbidity, digitizing then can be calculated turbidity according to the area S that is detected with the turbidity of additive method mensuration and the relation of area S.
Thereby S correspondingly measures turbidity with this area, needs only the moment that reaches predefined value at this turbidity, and the lamp that the notice reaction is finished is lighted, and perhaps sends and informs that the sound gets final product.
At this moment, be not that brightness is carried out turbidimetric analysis turbidimetry as direct parameter, but carry out turbidimetric analysis turbidimetry,,, can confirm yet and correctly to measure even then the light quantity of light-emitting component 8 has some variations if adopt it according to Luminance Distribution.
And then, even in stopple coupon 2, have fuzzy or bubble because all Luminance Distribution are not had big influence, so can be because of these yet former thereby error measurement.
In addition, if obtain the Luminance Distribution of horizontal direction by Flame Image Process, as 100% and standardization, then its curve is shown in Fig. 6 (a)～(d) maximum brightness.
At this, if according to the width of maximum brightness part being arranged to brightness 70% width W by 70% threshold value of standardized brightness, it is defined as turbidity, perhaps digitizing is with the turbidity of other method definition and the relation of brightness 70% width W, then, can calculate turbidity according to brightness 70% width W that is detected.
Then, react the lamp or the sound of ringing that finishes as long as light notice to the moment of predefined value greatly at the turbidity that determines like this.
In this case, be not that brightness is carried out turbidimetric analysis turbidimetry as direct parameter, but carry out turbidimetric analysis turbidimetry,,, can confirm yet and correctly to measure even then the light quantity of light-emitting component 8 has some variations if adopt it according to Luminance Distribution.
In addition, even in stopple coupon 2, have under the situation of fuzzy or bubble, also with above-mentioned the same, can be because of these former thereby error measurement.
And, in the above description, the situation when measuring turbidity according to Luminance Distribution only has been described, but has changed Luminance Distribution, according to too based on the situation of the colourity measure of spread turbidity of rgb signal etc.
That is, if produce the gonorrhoea white precipitate, because the light of light-emitting component 8 is detected as scattered light, so its colourity height of the part corresponding with hi-lite.
Thereby, replace Luminance Distribution according to colourity distribute can with the above-mentioned the same turbidity of measuring.
In addition, replace turbidity also passable with having or not of the fluoroscopy special genes (inspection object) of sample.
In this case, in stopple coupon 2, in sample, sneak into the fluorescent material of expression fluorescence reaction in advance.
In the present example and the DNA that is exaggerated (nucleic acid) produce to interact and enter in 2 dotted lines, as the ultraviolet ray of exciting light, the material of the fluorescent orange of generation 590nm is used as fluorescent material by irradiation 300nm.
In this case, the ultraviolet ultraviolet light-emitting diode that outputs to 300nm as light-emitting component 8 is embedded the bottom that is installed to aligned apertures 4, make a video recording it with video camera 6R, 6L, if Luminance Distribution or chrominance section according to this view data are measured fluorescence intensity, then, can detect and check having or not of object with above-mentioned the same.
And then, the major part of the embodiment of other of the optical detection device 11 when Fig. 7 is expression mensuration fluorescence.And then, for part additional prosign and the detailed shared with Fig. 1.
In the present example, observing with through hole 9 from each ... to the light path of video camera 6R, 6L, dispose half-reflecting mirror 12 and light filter 13, with the ultraviolet light of half-reflecting mirror 12 reflections, by observing with through hole 9 from the 300nm of ultraviolet light-emitting diode (luminescence unit) 14 irradiations ... shine each stopple coupon 2 as exciting light ... irradiation.
In this case, though the exciting light from light emitting diode 14 irradiation need be radiated at optical axis contraposition on the stopple coupon 2, do not need optical axis contraposition with video camera 6R, 6L.
As mentioned above, if adopt optical detection device 1,11 of the present invention, then played according to Luminance Distribution or colourity and distributed via the view data of observing the stopple coupon 2 of making a video recording with through hole 9, the optical variation of the gonorrhoea white precipitate that observation produces in sample can be judged this effect that has or not of checking object.
At this moment, because according to Luminance Distribution or the variation of colourity distribution viewing optics, so even the light quantity of the inspection light of irradiation stopple coupon 2 has some variations, suitably select threshold value and standardization by implementing Flame Image Process, also play and to get rid of the very excellent effect that changes the influence that causes because of light quantity.
In addition, in stopple coupon 2, have fuzzy or bubble can not have big influence to all Luminance Distribution yet, can correctly detect the very excellent effect of the optical variation of gonorrhoea white precipitate even played.
And then, on the position that the stopple coupon 2 that as long as video camera 6R, 6L are arranged on needs observation comes into view, whether as long as suitable its image of seeing just can extremely easily be confirmed because the position is set, so, played the very excellent effect of the assembling of possibility simplification device without any need for the optical axis contraposition of trouble.
In sum, optical detection device of the present invention is in biochemical, medical science pharmacy, field of food etc., can be used in simple and easy, rapid in as the sample of checking test portion, check that whether become specific pathogen or bacterium, microorganism or the chemical substance of checking object exists such purposes, can be used in especially by amplify the purposes that special genes checks that it has or not as the LAMP method correctly, cheaply.
Claims (5)
1. whether optical detection device has the inspection object of optical variations such as producing gonorrhoea white precipitate or fluorescence to the sample inspection of putting into stopple coupon, it is characterized in that, comprising: be formed with the reaction block of erectting a plurality of aligned apertures of arranging stopple coupon; By the observation on the side that is formed on above-mentioned reaction block with through hole or be formed on through hole on the bottom surface, to the luminescence unit of above-mentioned each stopple coupon examination light; Come video camera that each stopple coupon is made a video recording with through hole by above-mentioned observation; Be determined at the arithmetic processing apparatus of the optical variation that produces in the stopple coupon according to distributing with the brightness of above-mentioned video camera shot image data or colourity.
2. optical detection device as claimed in claim 1, it is characterized in that, from above-mentioned luminescence unit by the through hole on the bottom surface that is formed on reaction block to each stopple coupon examination light, and, the gonorrhoea white precipitate that produces in the sample is measured as optical variation according to Luminance Distribution that in view data, obtains or colourity distribution.
3. optical detection device as claimed in claim 1, it is characterized in that, shine and the exciting light of sneaking into the corresponding wavelength of fluorescent material in the sample in advance as above-mentioned inspection light, and, the fluorescence that produces in the sample is measured as optical variation according to Luminance Distribution that in view data, obtains or colourity distribution.
4. optical detection device as claimed in claim 1 is characterized in that, above-mentioned observation is formed on camera lens from video camera to the emission line of each stopple coupon with through hole.
5. optical detection device as claimed in claim 1 is characterized in that above-mentioned light-emitting component is arranged on the bottom of each aligned apertures.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP120649/2003 | 2003-04-24 | ||
| JP2003120649 | 2003-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1777804A true CN1777804A (en) | 2006-05-24 |
Family
ID=33308145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004800108843A Pending CN1777804A (en) | 2003-04-24 | 2004-04-23 | Optical inspection device |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060120566A1 (en) |
| JP (1) | JPWO2004095009A1 (en) |
| CN (1) | CN1777804A (en) |
| DE (1) | DE112004000698T5 (en) |
| WO (1) | WO2004095009A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102439420A (en) * | 2009-04-21 | 2012-05-02 | 生物系统Sa公司 | Photometric device for measuring absorbance and turbidity |
| CN107262177A (en) * | 2012-06-28 | 2017-10-20 | 弗洛雷森特里克公司 | Chemical indicator device |
| TWI756777B (en) * | 2020-08-10 | 2022-03-01 | 輝視科技股份有限公司 | Lamp structure for optical inspection |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877507B2 (en) * | 2007-04-06 | 2014-11-04 | Qiagen Gaithersburg, Inc. | Ensuring sample adequacy using turbidity light scattering techniques |
| DE202007016343U1 (en) * | 2007-11-19 | 2008-04-30 | Levin, Felix, Dr. | Device system for the rapid determination of substances in liquids with the aid of a computer-coupled video system |
| JP4822363B2 (en) * | 2007-12-12 | 2011-11-24 | 飛島建設株式会社 | Groundwater flow and turbidity measurement device |
| NL2002196C2 (en) * | 2008-11-11 | 2010-05-17 | Avantium Int Bv | SAMPLE ANALYZES APPARATUS AND A METHOD OR ANALYZING A SAMPLE. |
| NL2002368C2 (en) * | 2008-12-05 | 2010-06-08 | Avantium Holding B V | System and method for simultaneously performing phase behaviour tests on a plurality of samples. |
| DE102011003140A1 (en) | 2011-01-25 | 2012-07-26 | Hamilton Bonaduz Ag | Optical analysis method for liquid in a sample container and analysis device for carrying out the method |
| ITPI20120001A1 (en) * | 2012-01-04 | 2013-07-05 | Alessandro Bertocchi | METHOD FOR THE PRODUCTION OF PUREE, OR JUICE, FROM FOOD PRODUCTS WITH HIGH CAPACITY AND MACHINE THAT ACTIVES THIS METHOD |
| US9970868B2 (en) | 2013-08-22 | 2018-05-15 | Becton, Dickinson And Company | Nephelometry method and apparatus for determining the concentration of suspended particles in an array of sample containers |
| DE102013017148B4 (en) * | 2013-10-16 | 2015-08-06 | Heiko Langer | Liquid analysis method and analysis kit |
| JP6161072B2 (en) * | 2013-12-26 | 2017-07-12 | 国立研究開発法人産業技術総合研究所 | Multichannel chemiluminescence measurement system |
| BE1022861B1 (en) * | 2014-11-06 | 2016-09-27 | Vidimsoft Bvba | DEVICE FOR DIGITALIZING BLOOD GROUP CASSETTES |
| KR101802460B1 (en) * | 2015-12-22 | 2017-11-28 | 조원창 | Gene Diagnostic Apparatus |
| AT521189B1 (en) * | 2018-04-23 | 2021-01-15 | Meon Medical Solutions Gmbh & Co Kg | AUTOMATIC ANALYZER AND OPTICAL MEASURING METHOD FOR OBTAINING MEASUREMENT SIGNALS FROM LIQUID MEDIA |
| DE102020114414A1 (en) | 2020-05-29 | 2021-12-02 | Analytik Jena Gmbh | Temperature control device with optical unit |
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| JPS58140459U (en) * | 1982-03-17 | 1983-09-21 | 株式会社常光 | Laserne fluorometer |
| JPS617426A (en) * | 1984-06-21 | 1986-01-14 | Shimadzu Corp | Photometer |
| JPS6175263A (en) * | 1984-09-20 | 1986-04-17 | Toshiba Corp | Reaction tube cassette |
| US5093271A (en) * | 1986-11-28 | 1992-03-03 | Shimadzu Corporation | Method for the quantitative determination of antigens and antibodies by ratio of absorbances at different wavelengths |
| JPS63170761U (en) * | 1987-04-28 | 1988-11-07 | ||
| US4878114A (en) * | 1988-05-10 | 1989-10-31 | University Of Windsor | Method and apparatus for assessing surface roughness |
| US5594808A (en) * | 1993-06-11 | 1997-01-14 | Ortho Diagnostic Systems Inc. | Method and system for classifying agglutination reactions |
| WO1998011508A1 (en) * | 1996-09-16 | 1998-03-19 | Fey Stephen J | Method and apparatus for analyzing images |
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| US7482602B2 (en) * | 2005-11-16 | 2009-01-27 | Konica Minolta Medical & Graphic, Inc. | Scintillator plate for radiation and production method of the same |
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2004
- 2004-04-23 US US10/553,947 patent/US20060120566A1/en not_active Abandoned
- 2004-04-23 CN CNA2004800108843A patent/CN1777804A/en active Pending
- 2004-04-23 DE DE112004000698T patent/DE112004000698T5/en not_active Withdrawn
- 2004-04-23 JP JP2005505811A patent/JPWO2004095009A1/en active Pending
- 2004-04-23 WO PCT/JP2004/005952 patent/WO2004095009A1/en active Application Filing
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102439420A (en) * | 2009-04-21 | 2012-05-02 | 生物系统Sa公司 | Photometric device for measuring absorbance and turbidity |
| CN102439420B (en) * | 2009-04-21 | 2014-06-18 | 生物系统Sa公司 | Photometric device for measuring absorbance and turbidity |
| CN107262177A (en) * | 2012-06-28 | 2017-10-20 | 弗洛雷森特里克公司 | Chemical indicator device |
| CN107262177B (en) * | 2012-06-28 | 2020-07-10 | 弗洛雷森特里克公司 | Chemical indicator device |
| TWI756777B (en) * | 2020-08-10 | 2022-03-01 | 輝視科技股份有限公司 | Lamp structure for optical inspection |
Also Published As
| Publication number | Publication date |
|---|---|
| DE112004000698T5 (en) | 2006-03-30 |
| US20060120566A1 (en) | 2006-06-08 |
| WO2004095009A1 (en) | 2004-11-04 |
| JPWO2004095009A1 (en) | 2006-07-13 |
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