CN1772315A - Integrated control of ventilator and nebulizer operation - Google Patents
Integrated control of ventilator and nebulizer operation Download PDFInfo
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- CN1772315A CN1772315A CN 200510081112 CN200510081112A CN1772315A CN 1772315 A CN1772315 A CN 1772315A CN 200510081112 CN200510081112 CN 200510081112 CN 200510081112 A CN200510081112 A CN 200510081112A CN 1772315 A CN1772315 A CN 1772315A
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Abstract
A method of integrating the operations of a ventilator and a nebulizer to conduct respiratory therapy is provided. In one example, the method includes the steps of (1) providing a control unit in communication with a ventilator and nebulizer, the control unit arranged to obtain a control value based upon one or more ventilatory control parameters associated with the respiratory therapy; (2) operating the ventilator to provide the respiratory therapy to a patient; and (3) generating a modification signal from the control unit to automatically modify an operating condition of the nebulizer based upon the control value. In another example, the method includes the steps of (1) providing a control unit in communication with the ventilator and the nebulizer; (2) operating the ventilator and nebulizer to provide respiratory therapy to a patient, the nebulizer being operated at predetermined dosing periods; and (3) generating a modification signal from the control unit to automatically modify an operating condition of the ventilator based upon the operation of the nebulizer.
Description
The cross reference related application
This application requires the right of the provisional application No.60/582941 of submission on June 25th, 2004.
Technical field
The present invention relates to a kind of method that the respiratory organ treatment is provided for the patient.More specifically, the present invention relates to a kind of control and aerosol apparatus with respiratory organ combines so that the method for improved spraying treatment to be provided.The invention still further relates to a kind of control with respiratory organ combines so that the method for improved spraying treatment to be provided with aerosol apparatus and monitoring of respiration equipment.
Background technology
The clinician uses aerosol apparatus to carry for the patient who is connected with respiratory organ provides atomization medicine usually.Usually aerosol apparatus is placed the air-breathing tubing string of patient's pipeline, and atomization medicine is directly injected patient's gas flow with aerosol apparatus.Normally based on the equipment of aeromechanics or ultrasonic technology, this equipment moves a period of time to the aerosol apparatus of current techniques continuously, till the medicine of having carried each fractionated dose (discrete doses).When using by this way, aerosol apparatus is all imported atomization medicine in the air-breathing and expiration phase of ventilation, and quite a few that causes drug dose walked around the patient, and " wraparound " breathe pipeline, discharges by the exhalation valve of respiratory organ.In fact, owing to do not give the patient with drug conveying, so medicine has been wasted.
The novel sprayer of a kind of utilization " micropump " technology has been proposed recently.Micropump forces liquid medicine to pass through a dusting cover (for example: 3 microns), carries to produce atomization medicine.The advantage of this technology is, can carry out the beginning and the time-out of this nebulizer operation soon, and for control drug conveying during the specific period of respiration phase, this aerosol apparatus is ideal like this.In the current techniques document, people's such as people's such as Piper U.S. Patent No. 5479920 and Raabe U.S. Patent No. 5322057 has especially been discussed the nebulizer operation of this mode.
Although the nebulizer systems of prior art has illustrated the method for operating aerosol apparatus during specific respiration phase off and on, the optimal transport of patient's atomization medicine is depended on many parameters, these parameters are not directly related with respiration phase information.An example of this parameter is a drug type itself, owing to certain drug (for example: vasodilator) deposit to the depths of patient's lung, and other medicines (for example: bronchodilator) as long as deposit to patient's upper respiratory tract wish.Other parameter relevant with the aerosol apparatus optimization comprises: the position of aerosol apparatus in patient's pipeline (for example: at patient's threeway (wye), be in the upstream in the air-breathing tubing string), breathe pipeline type and capacity, the inspiratory flow rate of respiratory organ, the respiratory delivery type (for example: pressure or capacity, spontaneous or mechanical), and (that is, walk around or " wraparound ") partially flow velocity of respiratory organ.The nebulizer systems of current techniques even those operate the system of aerosol apparatus off and between respiratory period, can not respond these parameters, therefore can not produce best drug conveying treatment.
The nebulizer systems of prior art does not combine with the system that respiratory mechanics monitor is provided yet.Like this, the clinical information about the atomization medicine therapeutic effect is solicited in the operation that must not rely on aerosol apparatus.Therefore, the ventilation of current techniques and monitoring equipment need user's individual to regulate, so that desired therapeutic or simple physiological measurements operation are worked.Need time-consuming and uninteresting manual operations like this, therefore reduced system effectiveness loathsomely.
Hope combines aerosol apparatus function and respiratory mechanics monitor, to improve efficient and the usefulness to the monitoring and evaluation of Drug therapy effectiveness.In addition, utilize this combination to make and to control the atomization medicine treatment with the result of monitoring information.By this way, can eliminate the frequent generation that atomization medicine that some carries in cycle substantially exceeds whole effects of its realization.
Similarly, be desirable to provide a kind of system and method that respiratory organ and nebulizer operation are combined.Be desirable to provide the comprehensive respiratory organ control of nebulizer operation, thereby the amount and the time of delivery of the atomization medicine that is provided during the ventilation treatment are provided in the mode of possible full blast.Further be desirable to provide the comprehensive respiratory organ control of such nebulizer operation, to such an extent as to aerosol apparatus is automatically operated according in the above-mentioned series of parameters at least one.In addition, it would also be desirable to provide the comprehensive respiratory organ control of such nebulizer operation, to such an extent as to the clinician can assess the effect of atomization medicine treatment efficiently with integrated monitoring of respiration ability.At last, wish to utilize this automatic drug recruitment evaluation, with automatic control patient's atomization medicine is carried, till having obtained desired effect.
Summary of the invention
The invention provides a kind of like this method, the active operation of respiratory organ and aerosol apparatus is combined, so that patient's ventilation treatment is best.The present invention also provides a kind of like this method, the active operation of respiratory organ, aerosol apparatus and monitoring of respiration equipment is combined, so that patient's ventilation treatment is best.
In a preferred example, the operation of respiratory organ and aerosol apparatus is combined, may further comprise the steps with the method for carrying out respiratory therapy: (1) provides control unit, this control unit is communicated by letter with aerosol apparatus with respiratory organ, this control unit is set, makes it obtain a controlling value according to one or more ventilation control parameters relevant with respiratory therapy; (2) operate this respiratory organ, for the patient provides respiratory therapy; And (3) produce one from this control unit and revise signal, automatically to change the operating condition of this aerosol apparatus according to this controlling value.
In a preferred embodiment, in the different phase of patient respiratory, integrated respiratory organ and piezoelectric micro pump sprayer provide the primary ability of controlling this aerosol apparatus (for example, opening or close aerosol apparatus by electronic control signal).By responding at least one in the Several Parameters that obtains by integrated respiratory organ and aerosol apparatus, allow in the breathing cycle, to regulate automatically synchronous time lag and/or spray cycles, this primary ability provides best atomization medicine to carry.These parameters can comprise: drug type; The information that the respiratory organ inspection period obtains; Patient's pipeline type; Patient's pipeline capacity; Patient's circuit compliance; Patient's pipeline length; The position of aerosol apparatus in patient's pipeline; The inspiratory flow rate of respiratory organ; The maximal inspiratory flow rate of respiratory organ; The gulp capacity of respiratory organ; The bias current speed of respiratory organ; And/or the respiratory control type of respiratory organ, for example, pressure or capacity.Therefore, integrated approach of the present invention makes and to carry out the resting period of drug conveying and gas delivery optimum matching to the patient from aerosol apparatus, to realize the most effective conveying of given pharmaceutical formulation.
In another preferred example, the operation of respiratory organ and aerosol apparatus is combined, may further comprise the steps with the method for carrying out respiratory therapy:: (1) provides control unit, and this control unit is communicated by letter with aerosol apparatus with respiratory organ; (2) operate this respiratory organ and aerosol apparatus, for the patient provides respiratory therapy, at predetermined this aerosol apparatus of confession medicine cycleoperation; And (3) produce the modification signal from control unit, automatically to change the operating condition of respiratory organ according to the operation of this aerosol apparatus.
The combination of respiratory organ and aerosol apparatus further allows to respond aerosol apparatus " for the medicine cycle " (promptly, when operating aerosol apparatus, cycle when carrying Drug therapy off and on), more particularly, " for the medicine cycle " of response piezoelectric pump, automatically change the conveying of respiratory organ, to such an extent as to: (1) raises during aerosol apparatus supplies the medicine cycle or reduces the bias current amount; (2) suck breath feature (for example: pressure or capacity) at aerosol apparatus for changing during the medicine cycle; (3) during supplying the medicine cycle, aerosol apparatus changes the inhalation flow feature; (4) change inspiratory duration (comprising inspiratory standstill) at aerosol apparatus for during the medicine cycle; (5) change expiratory duration (comprising expiratory standstill) at aerosol apparatus for during the medicine cycle; And/or (6) change breathing rate at aerosol apparatus for during the medicine cycle.
In another preferred example, provide a kind of method that the operation of respiratory organ, aerosol apparatus and monitoring of respiration equipment is combined.This method may further comprise the steps: (1) provides control unit, and this control unit and respiratory organ, aerosol apparatus and monitoring of respiration devices communicating are provided with monitoring of respiration equipment, makes it obtain a monitor value according to one or more monitoring parameters relevant with respiratory therapy; (2) operation respiratory organ and aerosol apparatus are for the patient provides respiratory therapy; And (3) produce the modification signal from control unit, automatically to change the operating condition of aerosol apparatus according to this controlling value.
Respiratory organ and aerosol apparatus trigger automatic monitoring function with the combine startup, end or the intermediate point that allow aerosol apparatus dosage to carry of monitoring capability.For example, one embodiment of the present of invention comprise ventilation conveying, atomization medicine conveying and monitoring of respiration (promptly, the monitoring of respiratory mechanics monitor and/or breathing gas) combination, wherein respiratory mechanics monitor comprises following one or more: (1) functional residual capacity is measured; (2) lung pressure and airway resistance are measured; (3) compliance is measured; (4) drag measurement; (5) pressure volume loop; (6) flow-volume loop; (7) monitoring of pressure-flow ring, and breathing gas comprises following one or more: (1) end-tidal CO
2(2) CO
2Generation; (3) end-tidal O
2(4) O
2Consumption.Utilize this embodiment, can utilize the monitoring information that is obtained, beginning and/or the end for the medicine cycle that provide by aerosol apparatus are provided automatically.
Description of drawings
Below with reference to description of drawings the preferred embodiments of the present invention, wherein:
Fig. 1 is the structural representation of respiratory organ, aerosol apparatus and the gas monitor apparatus of prior art;
Fig. 2 is the sketch map for the Comprehensive Control of respiratory organ, aerosol apparatus and gas monitor apparatus;
Fig. 3 is the figure that typical breath cycle pressure swash is shown;
The schematically illustrated basis of Fig. 4 changes the step of the method for aerosol apparatus function automatically from one or more control parameters of respiratory organ and/or patient respiratory session information.
Detailed Description Of The Invention
In the preferred embodiments of the present invention of following detailed description, provide a kind of method that the active operation of respiratory organ and aerosol apparatus is combined.It should be understood that drawing and description are considered to the example of the principle of the invention.For example, though with reference to having the Engstrom Carestation that very strong nursing for treating is used
(a kind of Intensive Care Therapy respiratory system product) illustrated notion of the present invention, but the present invention also can be applicable in many other patient care devices, for example in anesthesia outfit or the emergency room device.For example, the respiratory organ that designs for the helium-oxygen gas mixture that provides as breathing gas combines with integrated nebulizer systems, in the emergency room device, can be applied in the treatment of asthmatic patient.
With reference to figure 1, show the typical structure that the air exchange system of ventilation gas stream is provided to the patient.
Respiratory organ 10 provides ventilation gas stream by patient's conduit 12 to patient 14.In the embodiment shown in fig. 1, the patient receives ventilation gas stream by gas shield 16, even expect that the conveying of various other types connects within the scope of the present invention.
Can operate this respiratory organ and Other related equipment, carry out various respiratory therapy process.As shown in Figure 1, provide aerosol apparatus 18 on respiratory organ, the patient heals with medicine.
Aerosol apparatus 18 is input to atomization medicine according to prescription period ground in the gas that is suitable for sucking of air-breathing patient's conduit 12 of the patient's pipeline of flowing through, and finally is input in patient's the respiratory tract and lung.In addition, patient's conduit 12 can be connected on the breathing gas monitoring equipment 20, and this breathing gas monitoring equipment 20 is used for monitoring the content and the quality of the respiratory organ air-flow that flows to patient 14.
Be understandable that in Fig. 1, respiratory organ 10, aerosol apparatus 18 and breathing gas monitoring equipment 20 are not communicated by letter each other.In 18 operating periods of aerosol apparatus, when aerosol apparatus 18 is input to patient's conduit 12 with atomization medicine, must manually stop the operation of gas monitor apparatus 20.In addition, known aerosol apparatus technology 18 comprises the equipment based on aeromechanics technology or ultrasonic technology, and this equipment moves a period of time continuously, up to the medicine of having carried each fractionated dose.When using by this way, aerosol apparatus is all imported atomization medicine in the air-breathing and expiration phase of ventilation, and quite a few that causes drug dose walked around patient, and " wraparound " breathe pipeline, discharges from the exhalation valve of respiratory organ.In fact, because medicine does not flow to patient, so this drug waste.
With reference now to Fig. 2,, is depicted as the preferred structure of using system of the present invention.As shown in Figure 2, respiratory organ and integrated display 24 provide ventilation gas stream by patient's conduit 12 to patient 14.Equally, aerosol apparatus 18 is communicated by letter with patient's conduit 12 separately with the checkout equipment such as breathing gas monitoring equipment 20.Like this, aerosol apparatus 18 can be input to atomization medicine in the gas stream in patient's conduit 12, and simultaneously, as desired, gas monitor apparatus 20 can be measured respiratory organ gas stream.
Aerosol apparatus 18 preferably comprises the micropump technology, and as mentioned above, this micropump technology forces liquid medicine to pass through dusting cover, is transported to the atomization medicine in patient respiratory road with generation.An example of this technology is that the trade mark of selling on the market is Aeroneb Pro
Aerosol apparatus.
In the embodiment shown in Figure 2, the control unit 27 of respiratory organ and display 24 is communicated by letter with the control unit 29 of aerosol apparatus 18 by communicating to connect 28.Equally, the control unit 27 of respiratory organ and display 24 is connected 30 by second communication and communicates by letter with the control unit 25 of breathing gas monitoring equipment 20.By this way, the control unit 27 of respiratory organ and display 24 can carry out two-way communication with aerosol apparatus 18 and breathing gas monitoring equipment 20.
What should reckon with is to replace with any communication mode by point to point network communicating to connect 28,30.For example, expection telecommunication and radio communication method are within the scope of the present invention.
Electromechanical ground is the Engstr m Carestation that GE HealthCare (GE health care companies) sells in conjunction with an example of the equipment of respiratory organ and aerosol apparatus
With reference to figure 3, show typical breath cycle pressure waveform.High pressure cycle comprises inspiratory cycle 31, and low pressure cycle comprises exhalation cycle 32.For during the medicine cycle, atomization medicine is intermittently carried with breath cycle and is taken place synchronously, as drug conveying " time of implementation " 34 and synchronously " time lag " 36 defined.
With reference now to Fig. 4,, aerosol apparatus 18 provides above-mentioned many advantages with combining of respiratory organ 27 electromechanical, comprises such ability: up to the desirable effect of acquisition, and after obtaining desirable effect, control is to patient's drug conveying automatically.According to the preferred embodiment of this method, in step 40, respiratory organ 24 provides ventilation support to the patient.During ventilation is supported, determine each stage of patient respiratory circulation in step 42.
In step 44, respiratory organ 24 obtains reference value or control parameter.To control parameter in step 47 by the clinician and be input to respiratory organ 24, or determine the control parameter automatically by respiratory organ 24 in step 48.Preferably, the control parameter comprises any one of various parameters of the optimal transport " time of implementation " 34 of the atomization medicine treatment that is used for determining flowing to the patient and " time lag synchronously " 36.The example of this parameter comprises: (1) drug type; (2) respiratory organ information that the inspection period is obtained; (3) patient's pipeline type; (4) patient's pipeline capacity; (5) patient's circuit compliance; (6) patient's pipeline length; (7) position of aerosol apparatus in patient's pipeline; (8) inspiratory flow rate of respiratory organ; (9) peak inspiratory flow of respiratory organ; (10) gulp capacity of respiratory organ; (11) the bias current speed of respiratory organ; And/or the respiratory control type of (12) respiratory organ, for example, pressure or capacity.
In step 46, respiratory organ one or more according in the above-mentioned control parameter automatically determine optimal transport " time of implementation " 34 and " time lag synchronously " 36, then in step 50, automatically control the function of aerosol apparatus 18.This automatic control allows the surgeon to provide a certain amount of atomization medicine in the mode of possible full blast.In step 52, the clinician also can manually begin or stop for the medicine cycle.
As other or optional step 54, that controls in step 50 supplied during the medicine cycle, can change ventilation and carrying, and was beneficial to the nebulization of the best.For example, the operation in conjunction with response aerosol apparatus 18 of respiratory organ 24 and aerosol apparatus 18, further permission changes the ventilation conveying automatically, to such an extent as to: (1) bias current during aerosol apparatus supplies the medicine cycle raises or reduces; (2) the breath feature (for example: pressure or capacity) that sucks for change during the medicine cycle at aerosol apparatus; (3) airflow characteristic that sucks for change during the medicine cycle at aerosol apparatus; (4) change inspiratory duration (comprising inspiratory standstill) at aerosol apparatus for during the medicine cycle; (5) change expiratory duration (comprising expiratory standstill) at aerosol apparatus for during the medicine cycle; And/or (6) change breathing rate at aerosol apparatus for during the medicine cycle.
Can further recognize by application of the present invention, aerosol apparatus, respiratory organ and patient monitor can be completely integrated in the system.Carry out in the Engstr of above-mentioned reference m Carestation thereby simplified this set, and found that this set has improved the efficient of automatic control patient treatment widely.For example, as shown in Figure 4, carry out respiration measurement by gas monitor apparatus 20 in step 56.Obtain breathing mechanics parameters and/or breathing gas measurement parameter in step 58.
Respiratory mechanics monitor can comprise following one or more: (1) residual capacity is measured; (2) lung pressure and measurement of airway resistance; (3) compliance is measured; (4) drag measurement; (5) pressure volume loop; (6) flow-volume loop; (7) pressure-flow ring.The breathing gas monitoring can comprise following one or more: (1) end-tidal CO
2(2) CO
2Generation; (3) end-tidal O
2(4) O
2Consumption.
Can be by controlling aerosol apparatus automatically for medicine cycle setting up procedure 56 and 58 in step 60.Utilization can be regulated the operation of aerosol apparatus and respiratory organ at breathing mechanics parameters and/or breathing gas measurement parameter that step 58 obtains, so that the ventilation treatment is best.
A lot of optional conceivable methods are arranged, be used for respiratory organ 24, aerosol apparatus 18 and respiratory monitor 20 are integrated, thereby obtain the effectiveness/accuracy of above-mentioned hope.For example, respiratory organ 24 can integrate with aerosol apparatus 18 and monitor 20, wherein:
Aerosol apparatus produces the monitoring sampling of breathing mechanics parameters and/or breathing gas parameter for the startup of medicine.
The monitoring sampling that aerosol apparatus produces breathing mechanics parameters and/or breathing gas parameter for finishing of medicine.
Obtain the monitoring sampling of breathing mechanics parameters and/or breathing gas parameter at the preset time relevant with spraying dosage.This time can continue to repeat to take place.For example integrated respiratory organ can carry out at once aerosol apparatus for before the medicine with at aerosol apparatus for after the medicine 15 minutes, the sampling breathing mechanics parameters, simultaneously, aerosol apparatus is for medicine automatic repetition in per 2 hours itself.
The mechanics of breathing and/or the breathing gas monitoring information that obtain in step 28 provide information, and atomization medicine is quantitatively for the automatic end of medicine step 22 or to begin be reaction to this information.For example, when the airway resistance measurement has descended by the specified amount of clinician, integrated ventilation conveying and sprayer device will stop the atomization medicine of bronchodilator and carry.(opposite, in the present practice, the drug conveying of specified quantitative is provided, and does not consider effect.Usually be, even after having reached whole effects of medicine, also carry the overdose of medicine thing.This " closed loop " operation allows the clinician in case obtained the just limit drug conveying automatically of desirable effect.)
Although the present invention is applicable to a lot of multi-form embodiment, drawing and description describe the preferred embodiments of the present invention in detail.They are not intended to wide in range aspect of the present invention is limited among the described embodiment.
Claims (20)
1, a kind of operation with respiratory organ and aerosol apparatus combine, to carry out the method for respiratory therapy, this method may further comprise the steps:
Provide and described respiratory organ and described aerosol apparatus control unit in communication, this control unit is set, make it obtain controlling value according to one or more control parameters relevant with described respiratory therapy;
Operate described respiratory organ, for the patient provides described respiratory therapy; And
According to described controlling value, produce the modification signal from described control unit, automatically to change the operating condition of described aerosol apparatus.
2, the method for claim 1, wherein in the breath cycle relevant with described respiratory therapy, described modification signal is regulated synchronous time lag automatically;
3, the method for claim 1, wherein in the breath cycle relevant with described respiratory therapy, described modification signal is regulated spray cycles automatically.
4, the method for claim 1, wherein described one or more control parameter comprises the drug type that is distributed by described aerosol apparatus.
5, the method for claim 1, wherein described one or more control parameter comprises the position of aerosol apparatus described in the patient respiration pipeline relevant with described respiratory organ.
6, the method for claim 1, wherein described one or more control parameter comprises the physical quality of the breathing pipeline relevant with described respiratory organ.
7, the method for claim 1, wherein described one or more control parameter comprises the inspiratory flow rate relevant with described respiratory organ.
8, the method for claim 1, wherein described one or more control parameter comprises the bias current speed relevant with described respiratory organ.
9, the method for claim 1, wherein described one or more control parameter comprises the respiratory delivery type relevant with described respiratory organ.
10, a kind of operation with respiratory organ and aerosol apparatus combine, to carry out the method for respiratory therapy, this method may further comprise the steps:
Provide and described respiratory organ and described aerosol apparatus control unit in communication;
Operate described respiratory organ and aerosol apparatus, for the patient provides respiratory therapy, at the selected described aerosol apparatus of confession medicine cycleoperation; And
According to the operation of described aerosol apparatus, produce the modification signal from described control unit, automatically to change the operating condition of described respiratory organ.
11, method as claimed in claim 10, wherein, the operating condition of described respiratory organ influences the bias current value that the patient accepts respiratory therapy.
12, method as claimed in claim 10, wherein, the operating condition of described respiratory organ influences the suction breath feature that the patient accepts respiratory therapy.
13, method as claimed in claim 10, wherein, the operating condition of described respiratory organ influences the inspiratory duration that described respiratory organ provides.
14, method as claimed in claim 10, wherein, the operating condition of described respiratory organ influences the expiratory duration that described respiratory organ provides.
15, method as claimed in claim 10, wherein, the operating condition of described respiratory organ influences the breathing rate that described respiratory organ provides.
16, a kind of method that the operation of respiratory organ, aerosol apparatus and monitoring of respiration equipment is combined, this method may further comprise the steps:
Control unit with described respiratory organ, aerosol apparatus and monitoring of respiration devices communicating is provided, described monitoring of respiration equipment is set, make it obtain monitor value according to one or more monitoring parameters relevant with described respiratory therapy;
Operate described respiratory organ and aerosol apparatus, for the patient provides described respiratory therapy; And
According to described controlling value, produce the modification signal from described control unit, automatically to change the operating condition of described aerosol apparatus.
17, method as claimed in claim 16, wherein, described monitoring parameter is based on respiratory mechanics monitor.
18, method as claimed in claim 17, wherein, described respiratory mechanics monitor comprises that functional residual capacity is measured, lung pressure and measurement of airway resistance, compliance measurement, drag measurement, pressure volume loop, flow-volume loop, and at least a in the pressure-flow ring.
19, method as claimed in claim 16, wherein, described monitoring parameter is monitored based on breathing gas.
20, method as claimed in claim 19, wherein, described breathing gas monitoring comprises end-tidal CO
2, CO
2Generation, end-tidal O
2And O
2At least a in the consumption.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58294104P | 2004-06-25 | 2004-06-25 | |
| US60/582,941 | 2004-06-25 |
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| Publication Number | Publication Date |
|---|---|
| CN1772315A true CN1772315A (en) | 2006-05-17 |
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ID=36759564
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510081112 Pending CN1772315A (en) | 2004-06-25 | 2005-06-27 | Integrated control of ventilator and nebulizer operation |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102844068A (en) * | 2009-12-02 | 2012-12-26 | 莱斯皮诺有限公司 | Drug delivery device |
| CN103251410A (en) * | 2012-02-17 | 2013-08-21 | 通用电气公司 | Apparatus, arrangement and method for analyzing breathing gas |
| CN101730560B (en) * | 2007-04-19 | 2015-01-07 | 伟康呼吸药物递送（英国）有限公司 | Ventilator aerosol delivery |
| CN105664329A (en) * | 2016-01-05 | 2016-06-15 | 湖南明康中锦医疗科技发展有限公司 | Atomization system cooperative with mechanical ventilation |
| CN106237470A (en) * | 2016-08-30 | 2016-12-21 | 中国人民解放军第三军医大学第三附属医院 | A kind of integral type oxygen-absorption atomizing pipe |
| CN110650764A (en) * | 2017-03-23 | 2020-01-03 | 斯坦福设备有限公司 | Aerosol delivery system and method |
| CN111569211A (en) * | 2020-05-26 | 2020-08-25 | 山东省千佛山医院 | Device of dosing of automatic treatment bronchospasm of general anesthesia |
-
2005
- 2005-06-27 CN CN 200510081112 patent/CN1772315A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101730560B (en) * | 2007-04-19 | 2015-01-07 | 伟康呼吸药物递送（英国）有限公司 | Ventilator aerosol delivery |
| CN102844068A (en) * | 2009-12-02 | 2012-12-26 | 莱斯皮诺有限公司 | Drug delivery device |
| CN102844068B (en) * | 2009-12-02 | 2016-10-26 | 莱斯皮诺有限公司 | Drug delivery device |
| CN103251410A (en) * | 2012-02-17 | 2013-08-21 | 通用电气公司 | Apparatus, arrangement and method for analyzing breathing gas |
| US10342456B2 (en) | 2012-02-17 | 2019-07-09 | General Electric Company | Apparatus, arrangement and method for analyzing breathing gas flowing along breathing tubing for subject breathing |
| CN105664329A (en) * | 2016-01-05 | 2016-06-15 | 湖南明康中锦医疗科技发展有限公司 | Atomization system cooperative with mechanical ventilation |
| CN106237470A (en) * | 2016-08-30 | 2016-12-21 | 中国人民解放军第三军医大学第三附属医院 | A kind of integral type oxygen-absorption atomizing pipe |
| CN110650764A (en) * | 2017-03-23 | 2020-01-03 | 斯坦福设备有限公司 | Aerosol delivery system and method |
| CN110650764B (en) * | 2017-03-23 | 2023-03-17 | 斯坦福设备有限公司 | Aerosol delivery system and method |
| CN111569211A (en) * | 2020-05-26 | 2020-08-25 | 山东省千佛山医院 | Device of dosing of automatic treatment bronchospasm of general anesthesia |
| CN111569211B (en) * | 2020-05-26 | 2022-11-08 | 山东省千佛山医院 | Device of dosing of general anesthesia automatic treatment bronchospasm |
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