CN1772009A - Production process of water soluble ginkgo leaf extract - Google Patents
Production process of water soluble ginkgo leaf extract Download PDFInfo
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- CN1772009A CN1772009A CN 200510003243 CN200510003243A CN1772009A CN 1772009 A CN1772009 A CN 1772009A CN 200510003243 CN200510003243 CN 200510003243 CN 200510003243 A CN200510003243 A CN 200510003243A CN 1772009 A CN1772009 A CN 1772009A
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- water soluble
- ginkgo leaf
- leaf extract
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Abstract
The present invention is production process of water soluble ginkgo leaf extract. Ginkgo leaf GBE coarse product as material is produced into the generation-V GBE through extraction with pure water or solvent in a lixiviation apparatus, letting stand, filtering, precipitating with water solution of gelatin, filtering, filtering, vacuum concentrating to dry, dissolving in anhydrous alcohol, filtering, vacuum concentrating, drying and crushing. The production process is simple, high and stable in product quality and low in product cost, and produces no toxic matter and waste, and the product is non-toxic, reliable, high in quality and high in water solubility.
Description
Technical field
The present invention relates to the Folium Ginkgo extract processing method of (being called for short GBE), in particular to the method for from the Folium Ginkgo extract crude product, producing water solubility extract.
Background technology
Folium Ginkgo has another name called Folium Ginkgo, is the leaf of Ginkgoaceae plant Ginkgo biloba (Ginkgo biloba), its bitter and puckery flavor, and property is flat, and because of it contains flavonoid glycoside and the terpene lactones composition is used as medicine, the useful heart is astringed the lung, removing dampness antidiarrheal effect.In recent years, people constantly study medical value and the extracting method that extracts Folium Ginkgo.The method of extracting Folium Ginkgo GBE at present is a lot of, many new processes have been applied for patent of invention, by retrieval, existing 25 relate to the patent application that Folium Ginkgo extracts, for example CN02134490.6 number " a kind of preparation method of Folium Ginkgo extract ", CN02129905.6 number " a kind of high-activity ginkgo leaf extract preparation and purposes ", CN03114825.5 number " preparation method of Folium Ginkgo extract ", CN03114826.3 number " preparation method of extractive of low acidic gingko leaves ", CN200410069037.6 number " a kind of Folium Ginkgo extract and extracting method thereof " etc.These applications all belong to the method for extracting general GBE from Folium Ginkgo, that extracts water solublity GBE only has No. 02113533.9 " production technology of water soluble ginkgo leaf extract " patent application, this process using macroporous adsorbent resin technology, be difficult to eliminate the adverse effect of resin residue thing, and can not solve water solublity, deproteinization, detanning matter simultaneously, take off ginkgoic acid and keep flavonoid glycoside and terpene lactones active constituent content, thereby can not satisfy of the requirement of Semen Ginkgo deep processing upgraded product raw material.
Summary of the invention
Purpose of the present invention just is to provide a kind of prior art shortcoming that overcomes, and is the raw material production water solubility extract with Folium Ginkgo GBE crude product--the method for Folium Ginkgo the 5th generation GBE.
Purpose of the present invention can realize by following scheme: with Folium Ginkgo GBE crude product is raw material, the GBE crude product is put into extraction equipment extract, leave standstill, filter with pure water or with stirring solvent, adding aqueous gelatin solution precipitates, leave standstill, filter, vacuum concentration is to doing, add anhydrous alcohol solution again, filter, vacuum concentration is also dry, pulverizes and promptly gets Folium Ginkgo the 5th generation GBE.
In the said extracted process, being used for the solvent of lixiviate has methanol, ethanol or acetone etc., and used solvent is a weak solution, and its mass fraction is 0.1%～45%, and extraction temperature is controlled under 20 ℃～50 ℃, and extraction time is 0.5～2 hour.
After lixiviate was finished, time of repose was 30 minutes～6 hours.
The mass fraction that filters back adding aqueous gelatin solution is 5%; The time that post precipitation leaves standstill again is 12～24 hours.
Drying mode adopts hot air drying usually; The quality that dry back adds dehydrated alcohol is 5～8 times of dry matter amount.
Folium Ginkgo the 5th generation GBE of the present invention, its product appearance is pale brown toner end; Flavonoid glycoside content 〉=24.0%; Terpene lactones content 〉=6.0% (wherein content of bilobalide 〉=2.8%); Ginkgoic acid content＜5mg/kg; Dissolubility in water＞5% is limpid transparent; Protein and tannin are all negative by the pharmacopeia qualitative detection.Can be used as the raw material of health food and biologics.
The inventive method has that production technology is easy, good product quality and the advantage stable, that cost is low.Its production technology is mainly by means such as control material temperature, concentration, precipitation and ultrafiltration, do not have any chemical change and generation toxic byproduct is arranged, and the overall process of technological operation is not used macroporous adsorbent resin, can avoid the influence of poisonous residue of macroporous adsorbent resin or analyte; In the operation overall process, only make water and edible ethanol, three-waste free pollution, product is nontoxic, and is safe and reliable; With short production cycle, cost is low, and quality is good; And the extract good water solubility meets the relevant quality standard requirement of state-promulgated pharmacopoeia, by the industrialization pilot production.
The specific embodiment
Following examples can further specify the present invention:
Embodiment 1
The first step feeds intake: get GBE crude product 20kg;
In second step, extract: in crude product, add the 200L pure water, in 25 ℃, stir and extracted 1.5 hours, left standstill 2 hours, filter;
In the 3rd step, precipitation: add 5% aqueous gelatin solution in filtrate, be stirred to no white depositions (white casse) by limit edged clockwise and occur, continue to stir about 10 minutes, left standstill 13 hours again, filter, vacuum concentration is to dried;
The 4th step, dissolving: in dry thing, add 6 times of absolute ethyl alcohol and stirring dissolvings by weight fully, filter;
In the 5th step, concentrate: filtrate is put into vacuum concentrator be concentrated into slurry;
The 6th step, use the hot air drying material under the vacuum, pulverize at last and obtain Folium Ginkgo the 5th generation GBE.
Embodiment 2
The first step feeds intake: get GBE crude product 50kg;
In second step, extract: adding the 500L mass fraction to the GBE crude product is 20% Diluted Alcohol solution, stirs in 40 ℃ and extracts 1.5 hours, leaves standstill 1 hour, filters;
In the 3rd step, filter: filtrate is just filtered by ceramic membrane earlier, enter 2000-10000 molecular weight ultrafiltration apparatus system again and carry out ultrafiltration;
In the 4th step, concentrate: ultrafiltrate is squeezed into be concentrated into slurry in the vacuum concentrator;
The 5th step, use the hot air drying material under the vacuum, pulverize at last and obtain Folium Ginkgo the 5th generation GBE.
Claims (6)
- The production method of 1 one kinds of water soluble ginkgo leaf extracts is characterized in that this method is a raw material with Folium Ginkgo GBE crude product, puts into extraction equipment with the GBE crude product and extracts with pure water or with stirring solvent, leave standstill, filter, add aqueous gelatin solution and precipitate, leave standstill again, filter, vacuum concentration adds anhydrous alcohol solution again to doing, and filters, vacuum concentration is also dry, pulverizes and promptly gets Folium Ginkgo the 5th generation GBE.
- 2 production methods according to the described water soluble ginkgo leaf extract of claim 1 is characterized in that in the leaching process, and being used for the solvent of lixiviate has methanol or ethanol or acetone, and used solvent is a weak solution, and its mass fraction is 0.1%～45%.
- 3 production methods according to the described water soluble ginkgo leaf extract of claim 1, it is characterized in that lixiviate is finished after, time of repose is 30 minutes～6 hours.
- 4 production methods according to the described water soluble ginkgo leaf extract of claim 1, the mass fraction that adds aqueous gelatin solution after it is characterized in that filtering is 5%.
- 5 production methods according to the described water soluble ginkgo leaf extract of claim 1 is characterized in that the time that post precipitation leaves standstill again is 12～24 hours.
- 6 production methods according to the described water soluble ginkgo leaf extract of claim 1 is characterized in that dry run adopts hot air drying usually, and the quality that dry back adds dehydrated alcohol is 5～8 times of dry matter amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510003243 CN1772009A (en) | 2005-10-19 | 2005-10-19 | Production process of water soluble ginkgo leaf extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510003243 CN1772009A (en) | 2005-10-19 | 2005-10-19 | Production process of water soluble ginkgo leaf extract |
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| CN1772009A true CN1772009A (en) | 2006-05-17 |
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| CN 200510003243 Pending CN1772009A (en) | 2005-10-19 | 2005-10-19 | Production process of water soluble ginkgo leaf extract |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596221B (en) * | 2008-06-04 | 2012-06-20 | 上海信谊百路达药业有限公司 | Process for preparing water-soluble ginkgo biloba extract used for injection |
| CN105687263A (en) * | 2016-03-16 | 2016-06-22 | 浙江新昌天然保健品有限公司 | Preparation process of ginkgo biloba extract and water-soluble ginkgo biloba extract |
| CN110192588A (en) * | 2019-06-13 | 2019-09-03 | 四川顺翔银杏生物科技开发有限公司 | A kind of ginkgo leaf granular tea and preparation method thereof |
-
2005
- 2005-10-19 CN CN 200510003243 patent/CN1772009A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596221B (en) * | 2008-06-04 | 2012-06-20 | 上海信谊百路达药业有限公司 | Process for preparing water-soluble ginkgo biloba extract used for injection |
| CN105687263A (en) * | 2016-03-16 | 2016-06-22 | 浙江新昌天然保健品有限公司 | Preparation process of ginkgo biloba extract and water-soluble ginkgo biloba extract |
| DE102017204379B4 (en) * | 2016-03-16 | 2020-02-06 | Zhejiang Xinchang Natural Health Products Co., Ltd. | Production process of a water-soluble ginko leaf extract |
| CN110192588A (en) * | 2019-06-13 | 2019-09-03 | 四川顺翔银杏生物科技开发有限公司 | A kind of ginkgo leaf granular tea and preparation method thereof |
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