CN1756526A - Low irritation lathering formulations - Google Patents
Low irritation lathering formulations Download PDFInfo
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- CN1756526A CN1756526A CNA2004800059230A CN200480005923A CN1756526A CN 1756526 A CN1756526 A CN 1756526A CN A2004800059230 A CNA2004800059230 A CN A2004800059230A CN 200480005923 A CN200480005923 A CN 200480005923A CN 1756526 A CN1756526 A CN 1756526A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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Abstract
This invention relates to lathering skin-care products containing particular surfactant systems that provide good lathering and low irritation, said surfactant system containing: (a) one or more alkyl or alkenyl oligoglucosides, (b) one or more amphoteric surfactants, and (c) one or more anionic co-surfactants; the weight ratio of the alkyl glucosides and amphoteric surfactants to the anionic cosurfactants [(a + b) : c] being such that it is in the range of 1.1 : 1 to 10 : 1.
Description
The invention summary
The present invention relates to contain the foaming cleansing preparation of special surfactant system, this system can provide good foam and low irritant.
Background of invention
Surfactant is the fundamental component of cleaning formulation (for example shampoo, bath gel), and it provides cleaning, degrease performance and foamability.Though the latter is not very important for the actual performance of Cleasing compositions, consumer thinks that this is its basic quality.Existing cleaning formulation contains various types of surfactant mixtures that above-mentioned quality is arranged.
Adding anion surfactant is because its good frothing capacity.Except the basic foam that good quantity is provided, anion surfactant also can increase foamy quality, especially increases foamy formation and its kinetics.Anion surfactant can provide stable foam, even promptly foam also is difficult for broken at the environment that has fat with in hard water and can keeps the sufficiently long time.The problem relevant with using anion surfactant is that frequent the use is easy to make xerosis cutis and the generation intolerance to the type surfactant.This problem especially appears at sensitive skin and is applied under baby's the situation.Another problem relevant with anion surfactant is to be easy to cause zest and sensation of pricking, especially for eyes and responsive on every side skin area thereof.
For increasing skin-tolerant, further added the surfactant that is called cosurfactant, but found that they have produced harmful effect to the frothing capacity of anion surfactant.Therefore can only in cleaning formulation, add a spot of cosurfactant.
WO97/26860 has disclosed and can clean and the conditioning shampoo composition of conditioning hair, and it contains anion, nonionic and amphoteric surfactant and contains the conditioning system of two kinds of special conditioning polymers at least.
WO98/24409 has disclosed the waterborne compositions that the body and function of very strong foamability cleaning formulation is arranged, and it contains anion surfactant, alkyl (oligomerization) glucoside and combines zwitterionic surfactant and amphoteric surfactant.Though said preparation allegedly has good frothing capacity and skin is had good toleration, but they still contain the anion surfactant of relative higher concentration, this frothing capacity for these compositionss needs, but just do not make us satisfied fully with regard to soft property, especially for the soft property of eyes.
Therefore, foaming cleansing preparation, the especially shampoo that need provide the individual to use.These preparations will have the advantages of good skin toleration, and more specifically saying so has skin-tolerant to sensitive skin and baby.Need in addition to provide to skin, particularly eyes and regional non-irritating foaming cleansing compositions on every side thereof.Also need these preparations enough cleaning capacities to be arranged, stablize and can provide the competent foam that better quality and stability are arranged.
Preparation of the present invention has reduced the content of anion surfactant, but still good foaming quality can be provided and reduce to the zest of skin with to the sensation of pricking of eyes.Preparation of the present invention in addition can further reduce the surfactant total content and its cleaning and frothing capacity do not produced harmful effect.
Summary of the invention
The present invention relates to contain the foaming skin care formulation of surfactant system, this surfactant system contains:
(a) one or more alkyl or alkenyl oligomerization glucoside,
(b) one or more amphoteric surfactantes and
(c) one or more anion cosurfactants;
The weight ratio of alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.1: 1 to 10: 1, and wherein the transdermal penetration of said preparation (TEP) value is equal to or greater than 1.95.
The present invention further provides the foaming skin care formulation that contains surfactant system, this surfactant system contains:
(a) one or more alkyl or alkenyl oligomerization glucoside,
(b) one or more amphoteric surfactantes and
(c) one or more anion cosurfactants;
The weight ratio of alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.1: 1 to 10: 1, and wherein the total concentration of beet alkali surface activator is no more than about 2 weight %.
The total concentration of preferred beet alkali surface activator is no more than 1.5% preparation, and more preferably the total concentration of beet alkali surface activator is no more than 1 weight %'s.The preparation that is substantially devoid of betanin is especially interesting.
On the other hand, the present invention relates to described one or more alkyl of the 2 weight % that have an appointment or the foaming skin care formulation of alkenyl oligomerization glucoside of containing at least of description.At least it is especially interesting containing one or more alkyl of the 3 weight % that have an appointment or those preparations of alkenyl oligomerization glucoside.
In context, describe in detail, the TEP value is equal to or higher than approximately 1.95, it is especially interesting perhaps being equal to or higher than 2.00 preparation.
The total concentration of anion surfactant is lower than 7 weight % with respect to the ratio of the gross weight of preparation in the further preferred preparation of the present invention, especially is lower than 5 weight %, more particularly is lower than 4 weight %, or is lower than 3 weight %'s.
The preferred specific embodiment of the present invention provides the foaming that contains surfactant system skin care formulation, and this surfactant system contains:
(a) one or more alkyl or alkenyl oligomerization glucoside;
(b) one or more are selected from down the amphoteric surfactant of group: both sexes alkanoate, both sexes two alkanoates, amino-alkane acid esters and imino group alkanoate;
(c) one or more anion cosurfactants;
Alkyl androstanediol and amphoteric surfactant and be 1.5: 1 to 10: 1 to the weight ratio [(a+b): c] of anion cosurfactant.
One of the present invention is characterised in that especially the amount of anion surfactant is less than the total amount of all non-ionic surface active agents.Therefore anion surfactant is considered as " cosurfactant ".
On the other hand, the present invention relates to contain the purposes of the composition (a) and (b) that describe in detail in the literary composition and mixture (c), this mixture in the foaming cleansing preparation that the individual uses as surfactant system.
Detailed Description Of The Invention
No matter when any percentage rate of using in the description all refers to weight percent, the weight ratio of the relative total formulation weight amount of its expression composition.
Refer to composition (a) and (b) and gross weight (c) in the combinations-of surfactants of the various definition of preparation of the present invention separately with a, b in the text for example [(a+b): c] and other formula and c.
Alkyl or alkenyl oligomerization glucoside
Preparation of the present invention contains alkyl or alkenyl oligomerization glucoside, and they are non-ionic surface active agents known, that meet structural formula (I).
R
1O-[G]
p (I)
R wherein
1Be alkyl and/or the kiki alkenyl group that contains 4 to 22 carbon atoms, G is the sugar unit that contains 5 to 6 carbon atoms, and p is a numeral in 1 to 10.These oligomerization glucosides can obtain by the preparation method in the known technology and much these compositions can be commercially available.
Alkyl and/or alkenyl oligomerization glucoside can derive from aldose or the ketose that contains 5 or 6 carbon atoms, preferred glucose.Therefore, preferred alkyl and/or alkenyl oligomerization glucoside are alkyl and/or alkenyl oligomerization glucoside.Index p in the universal architecture formula (I) refers to the degree (being the distribution situation of monomer and oligomerization glucoside) of oligomerization (DP) and is a numeral in 1 to 10.Although p must be integer and at first suppose it is 1 to 6 in the chemical compound of a hypothesis, the p value in certain specific alkyl oligomerization glucoside is the numerical value that calculates by assay determination, and it is a mark normally.Preferred use average oligomerization degree p at 1.1 to 3.0 alkyl and/or alkenyl oligomerization glucoside.From application point, preferred oligomerization degree be lower than 1.7, especially alkyl between 1.2 and 1.5 and/or alkenyl oligomerization glucoside.Alkyl or kiki alkenyl group R
1Can derive from and contain 4 to 11, the primary alconol class of preferred 8 to 10 carbon atoms.Typical example is: butanols, hexanol, capryl alcohol, decanol and tip-nip with and synthetical mixture, these mixture derive from, for example the hydrogenation of the hydrogenation of artificial fat acid methyl ester or the aldehydes that obtained by the Roelen oxo synthesis.Preferred chain length C
8To C
10The alkyl oligomerization glucoside of (DP=1 to 3) and with artificial C
9-11Oxo alcohol (DP=1 to 3) be the basis alkyl oligomerization glucoside, the former is the artificial C of separated
8-18First effluent in the coconut fatty alcohols also contains the C that is lower than 6 weight %
12Alcohols is as impurity.In addition, alkyl or kiki alkenyl group R
1Can derive from contain 10 to 22, especially 12 to 22, the primary alconol class of preferred 12 to 16 carbon atoms.Typical example is: decanol, lauryl alcohol, myristyl alcohol, hexadecanol, hexadecylene alcohol, octadecanol, isooctadecane alcohol, oleyl alcohol, anti-oleic alcohol, petroselinum alcohol, arachidic alcohol, suitable (formula) 9-gadoleyl alcohol, tadenan, erucyl alcohol, Brazilian enol and its industrial grade mixture that obtains with said method.Especially interesting is to contain the C that derives from the Cortex cocois radicis lipidol
8-18The alkyl group mixture, be called the Cortex cocois radicis glucoside.Preferred DP is 1 to 3, with hydrogenant C
12-14Coconut fatty alcohols is the alkyl oligomerization glucoside on basis.
Amphoteric surfactant
The present composition additionally contains both sexes or zwitterionic surfactant.The exemplary of both sexes or zwitterionic surfactant is alkyl betaine, alkyl amido betanin, alanine ester, amino glycinate, imidazoles betanin, sulfobetaines and both sexes acetate.The surfactant of these types all is compound known.
Preparation of the present invention preferably only contains detailed indicated concentration in a spot of betanin, the especially literary composition.The preparation that is substantially free of betanin is especially interesting.The latter means that preparation does not contain or only contain a spot of betanin, for example is less than about 0.5 weight % or even less than about 0.3 weight % or be less than about 0.1 weight %.
Betanin
Betanin is known surfactant, and they are mainly by aminated compounds carboxyl alkanisation, and preferred carboxyl methylates and makes.Initial substance preferably with halogenated carboxylic acid or its salt, especially with the condensation of chloracetic acid sodium, the salt of each mole can obtain one mole betanin.Also can add undersaturated carboxylic acid (for example acrylic acid).The example of suitable betanin is the carboxyl alkylated product of the secondary amine that meets structural formula (II), particularly tertiary amine.
R wherein
2Be alkyl and/or the kiki alkenyl group that contains 6 to 22 carbon atoms, R
3Be hydrogen or the alkyl group that contains 1 to 4 carbon atom, R
4Be the alkyl group that contains 1 to 4 carbon atom, n is a numeral in 1 to 6, and X is a kind of alkali metal and/or alkaline-earth metal or ammonium group, and the latter comprises ammonium unsubstituted or that replace, for example alkylammonium, alkanol ammonium and sugared ammonium.Typical example is the carboxyl methylate of following aminated compounds: hexyl methyl amine, hexyl dimethyl amine, octyldimethyl amine, decyl dimethyl amine, dodecyl methyl amine, dodecyl dimethyl amine, dodecyl ethylmethylamine, C
12-14Cocos nucifera oil alkyl dimethyl amine, myristyl dimethyl amine, hexadecyldimethyl benzyl ammonium amine, octadecyl dimethyl amine, octadecyl ethylmethylamine, oil base dimethyl amine, C
16-18Tallow alkyl dimethyl amine and its industrial grade mixture.
Other suitable betanin is the carboxyl alkylated product that meets the amidoamines compounds of structural formula (III).
R wherein
5CO has 6 to 22 carbon atoms and 0 or 1 to 3 two key aliphatic acyl radical groups is arranged, and m is a numeral in 1 to 3, R
3, R
4, n and X and above-mentioned same meaning.Typical example is to contain the fatty acid of 6 to 22 carbon atoms and the product of aminated compounds and the condensation of chloracetic acid sodium, be caproic acid, sad, capric acid, lauric acid, myristic acid, Palmic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petroselic acid, linoleic acid, linolenic acid, eleostearic acid, arachidic acid, along (formula) 9-eicosenoic acid, behenic acid and erucic acid and its artificial mixt and N, N-dimethyl aminoethyl amine, N, N-dimethylaminopropyl amine, N, N-diethylamino ethylamine and N, N-diethylamino propyl group amine.Preferred C8-18 fatty acid distribution of coconut oil-N, the condensation product of N-dimethylaminopropyl amide and chloracetic acid sodium of using.
The betanin of added the present invention preparation of another type is the imidazolines shown in the structural formula (IV).
R wherein
6Representative contains the alkyl of 5 to 21 carbon atoms, R
7Representation hydroxy, OCOR
6-or NHCOR
7-group and m equal 2 or 3.These materials also are compound known, can prepare by for example 1 or 2 mole fatty acid and multivalence aminated compounds (for example amino ethyl ethanolamine (AEEA) or diethylenetriamines) cyclic condensation.Corresponding carboxyl alkylated product has generated different multichain betanin mixture.Typical example is above-mentioned fatty acid and the condensation product of AEEA, preferably by lauric acid or C
12-14The imidazoline that-coco-nut oil fatty acid makes, it changes betanin into chloracetic acid sodium subsequently.
Both sexes alkanoate, both sexes two alkanoates, amino-alkane acid esters and imino group alkanoate
Alkyl or alkenyl-both sexes alkanoate or both sexes two alkanoates can the universal architecture formula V shown in:
R wherein
aRepresentative contains the alkyl or the alkenyl of 10 to 24 carbon atoms, generally is cocos nucifera oil chain or lauryl chain; Each AIK represents alkylidene, particularly C
1-4Alkylidene, especially CH
2Or CH
2CH
2R
bRepresent hydrogen (for example in both sexes acetate or both sexes propionate) or-AIK-C (O) OM (for example in both sexes diacetin or both sexes dipropionate); And each M represents a hydrogen atom, a kind of alkali metal or a kind of alkaline-earth metal or amine or ammonium group, and the latter comprises ammonium unsubstituted or that replace, for example alkylammonium, alkanol ammonium and sugared ammonium.
Alkyl or alkenyl both sexes acetate, alkyl or alkenyl both sexes diacetin, alkyl or alkenyl both sexes propionate or alkyl or alkenyl both sexes dipropionate are interesting.And especially interesting be alkyl both sexes acetate or diacetin and alkyl both sexes propionate or dipropionate, preferred alkyl is lauryl or cocoyl.
Used alkyl and alkenyl refer to contain have an appointment 4 to 30, the alkyl of 8 to 22 carbon atoms particularly in the literary composition.Also above define relevant of alkyl or alkenyl with alkyl or alkenyl glucoside.
Available another kind of amphoteric surfactant is the alkyl shown in the following structural formula or alkenyl amino alkanoate and alkyl or alkenyl imino group alkanoate in the preparation of the present invention:
R
c-NH-AIk-COO-M
R
c-N(AIk-COO-M)
2
R wherein
cRepresentative contains the alkyl or the alkenyl of 10 to 24 carbon atoms, generally is cocos nucifera oil chain or lauryl chain; M and AIk as above define.Alkyl or alkenyl amino propionate are especially interesting.
Preferred amphoteric surfactant is the both sexes acetates, and especially preferred is Laurel both sexes acetates.
The anion cosurfactant
Exemplary as the anion surfactant of cosurfactant in the preparation of the present invention is a soap; alkylbenzenesulfonate; paraffin sulfonate; alkene sulfonate; alkylether sulfonate; glycerol ether sulfonate; the Alpha-Methyl sulfonated ester; sulfo-fatty acid; alkyl sulfate; fatty alcohol ether sulphate; glycerol ether sulfate; fatty acid ether sulfate; hydroxyl compound ether sulfate; monoglyceride (ether) sulfate; fatty acid amide (ether) sulfate; list and dialkyl sulfosuccinates; list and dialkyl sulfosuccinate Succinamate; the sulfo group triglyceride; the amide soap; ether carboxylic acid and its salt; fatty acid carboxyethyl sulphonic acid ester; the fatty acid sarcosinate; fatty acid taurine ester; N-acylamino acid (acyl-lactate for example; acyl group tartaric acid salt; acyl glutamate and acylaspartic acid salt); alkyl oligomerization glucoside sulfate; the protein fatty acid condensation product product of plant Semen Tritici aestivi (particularly based on) and alkyl (ether) phosphate.Contain the occasion of polyglycol ether chain at anion surfactant, they may have conventional homology and distribute, but preferred narrow homology distributes.The preferred alkyl ether sulfate is as the anion cosurfactant.
Alkyl ether sulfate
Alkyl ether sulfate (" ether sulfate ") also is known anion surfactant, and its suitability for industrialized production is by aliphatic alcohol or oxo alcohol polyglycol ether and sulfonic acid or chlorosulfonic acid (CSA) sulfation, and neutralization is carried out then.The ether sulfate that is suitable for the object of the invention should meet structural formula (VI):
R
8O-(CH
2CH
2O)
mSO
3X (VI)
R wherein
8Be straight or branched alkyl and/or the alkenyl group that contains 6 to 22 carbon atoms, n is a numeral in 1 to 10, and X is alkali metal and/or alkaline-earth metal, ammonium, alkylammonium, alkanol ammonium or sugared ammonium.Typical example is the sulfate of the addition compound product of following alcohol, be about to average 1 to 10 and particularly 2 to 5 moles oxirane add to the artificial mixt of hexanol, capryl alcohol, 2-Ethylhexyl Alcohol, decanol, lauryl alcohol, different tridecyl alcohol, myristyl alcohol, palmityl alcohol, hexadecylene alcohol, octadecanol, isooctadecane alcohol, oleyl alcohol, anti-oleic alcohol, petroselinum alcohol, arachidic alcohol, suitable (formula) 9-gadoleyl alcohol, tadenan, erucyl alcohol, Brazilian enol and its sodium salt and/or magnesium salt form.Ether sulfate promptly can have conventional homologue to distribute also can have narrow homologue to distribute.Especially preferred average 2 to 3 moles oxirane and the technical grade C that uses with sodium salt or magnesium salt form
12-14Or C
12-18The adduct of coconut fatty alcohols component gained be the ether sulfate on basis.
The total concentration of surfactant in the preparation of the present invention ((a)+(b)+(c)) is 0.1 to 20 weight % of total formulation weight amount, particularly at 1 to 15 weight %, more in 5 to 13 weight % or 5 to 12 weight % scopes.
The preparation that the present invention is special has following component:
(a) the alkyl oligomerization glucoside of 0.1 to 20 weight %,
(b) amphoteric surfactant of 0.1 to 20 weight %; With
(c) O.1 to the anion cosurfactant of 20 weight %;
Alkyl androstanediol and amphoteric surfactant and be 1.1: 1 to 10: 1 to the weight ratio [(a+b): c] of anion cosurfactant, and add other suitable composition quantity is supplied 100%.
Preferred preparation has following component:
(a) the alkyl oligomerization glucoside of 1 to 10 weight %,
(b) amphoteric surfactant of 1 to 10 weight %; With
(c) the anion cosurfactant of 1 to 10 weight %;
The weight ratio of alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.5: 1 to 5: 1, and adds other suitable composition quantity is supplied 100%.
Preferred preparation has following component:
(a) the alkyl oligomerization glucoside of 2 to 10 weight %,
(b) amphoteric surfactant of 2 to 10 weight %; With
(c) the anion cosurfactant of 2 to 5 weight %;
The weight ratio of alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 2: 1 to 3: 1, and adds other suitable composition quantity is supplied 100%.
Preferred again preparation has following component:
(a) 2 to 8 weight %'s or the alkyl oligomerization glucoside of 3-5 weight % particularly,
(b) amphoteric surfactant of 2 to 5 weight % and
(c) the anion cosurfactant of 2 to 5 weight %.
The weight ratio of surfactant in particularly preferred preparation (alkyl androstanediol is to amphoteric surfactant and anion cosurfactant) [a: b: c] is (1.0 to 1.5): (1.0 to 1.3): 1.
Any that in context, address, wherein amphoteric surfactant is selected from down that the preparation of group all can cause special interest: both sexes alkanoate, both sexes two alkanoates, amino-alkane acid esters and imino group alkanoate.Any that in context, address, wherein amphoteric surfactant is selected from down that the preparation of group all can cause further interest: alkyl or alkenyl both sexes acetate, alkyl or alkenyl both sexes diacetin, alkyl or alkenyl both sexes propionate or alkyl or alkenyl both sexes dipropionate.More interesting is alkyl both sexes acetate or diacetin and alkyl both sexes propionate or dipropionate, partly preferred lauryl of alkyl wherein or cocoyl.Preferred in the text the use contained 4 to 30 carbon atoms, the particularly alkyl and the alkenyl of the alkyl of 8 to 22 carbon atoms.
Foaming preparations of the present invention can be prepared into various cleaning products, for example shampoo, foam bath dew, bath gel and other cleaning formulation.
These preparations can further contain adjuvant and additive, for example mild surfactant, oily composition, emulsifying agent, superfatting agent, pearlescent waxes (pearlizing waxe), denseness promoter, thickening agent, polymer, silicone chemical compound, oils and fats, wax, lecithin, phospholipid, stabilizing agent, source of students agent (biogenic agent), deodorizer, dandruff removing agent, film former, extender, the ultraviolet protection factor, antioxidant, hydrotropic solvent, antiseptic, anthelmintic, tyrosine kinase inhibitors, solubilizing agent, aromatic oil, stain etc.
Denseness promoter and thickening agent
Optional composition in the preparation of the present invention is denseness promoter and thickening agent.
Specially suitable denseness promoter is to contain 12 to 22, the aliphatic alcohol of preferred 16 to 18 carbon atoms, also has partial glyceride in addition.These materials preferably-12-hydroxy stearic acid ester poly-with the fatty acid-N-methyl glucose amide of alkyl oligomerization glucoside and/or identical chain length and/or polyglycerol are united use.
Suitable thickening is, for example hydrophilic silica product (Aerosil
), polysaccharide, more specifically say so xanthan gum, guar gum, agar, alginate and tylose, carboxymethyl cellulose and hydroxyethyl-cellulose also include the polyethylene glycol fatty acid monoesters of relative higher molecular weight and fatty acid diester, polyacrylate (Carbopol for example
With Pemulen type [Goodrich], Synthalens
[Sigma], Keltrol
[Kelco], Sepigel
[Seppic], Salcare
[Allied Colloids]), polyacrylamide, polymer, polyvinyl alcohol and polyvinylpyrrolidone.Bentonite also is specially suitable, for example Bentone
Gel VS-5PC[Rheox], this is the mixture of ring penta siloxanes, distearyl acid dimethylammonium (disteardimonium) Strese Hofmann's hectorite. and propylene carbonate.Surfactant also is suitable, the esters (for example tetramethylolmethane or trimethylolpropane) that forms of the fatty glyceride of ethoxylation, fatty acid and polyol for example, the fatty acid ethoxylates of close limit or alkyl oligomerization glucoside and electrolyte (for example alkali metal or alkali salt, particularly halogenide, for example sodium chloride and ammonium chloride).
Preferred polyethylene glycol fatty acid, especially preferred PEG-distearate.
The quantity that is used in denseness promoter in the preparation of the present invention and thickening agent is by the needed viscosity decision of these preparations, and its viscosity scope can be 1,000 to 10,000mPas, preferably 3,000 to 6,000mPas (Brookfield viscosimeter, spindle4,10r.p.m. ,+/-3 ℃).
The composition that other is optional
Addible suitable oily composition is, for example based on aliphatic alcohol, contain the Guerbet alcohol of 6 to 18 carbon atoms, preferred 8 to 10 carbon atoms, straight chain C
6-22Fatty acid and straight chain C
6-22The ester that aliphatic alcohol forms, side chain C
6-13Carboxylic acid and straight chain C
6-22The ester that aliphatic alcohol forms (myristyl myristate for example, the Palmic acid myristin, the stearic acid myristin, the isostearic acid myristin, the oleic acid myristin, the behenic acid myristin, the erucic acid myristin, myristic acid hexadecane ester, cetyl palmitate, cetyl stearic, isostearic acid hexadecane ester, oleic acid hexadecane ester, behenic acid hexadecane ester, erucic acid hexadecane ester, myristic acid octadecane ester, Palmic acid octadecane ester, stearic stearolactone, isostearic acid octadecane ester, oleic acid octadecane ester, behenic acid octadecane ester, erucic acid octadecane ester, myristic acid isooctadecane ester, Palmic acid isooctadecane ester, stearic acid isooctadecane ester, isostearic acid isooctadecane ester, oleic acid isooctadecane ester, behenic acid isooctadecane ester, oleic acid isooctadecane ester, the oil base myristinate, the oil base cetylate, the oil base stearate, the oil base isostearate, the oil base oleate, oil base docosane acid esters, the oil base eruciate, myristic acid docosane ester, Palmic acid docosane ester, stearic acid docosane ester, isostearic acid docosane ester, oleic acid docosane ester, behenic acid docosane ester, erucic acid docosane ester, myristic acid savoy ester, Palmic acid savoy ester, stearic acid savoy ester, isostearic acid savoy ester, oleic acid savoy ester, behenic acid savoy ester, erucic acid savoy ester.Straight chain C
6-22The ester (especially 2-Ethylhexyl Alcohol) that fatty acid and branched-chain alcoho form, hydroxy carboxylic acid and straight or branched C
6-22The ester (especially malic acid dioctyl ester) that aliphatic alcohol forms, straight chain and/or branched chain fatty acid and polyhydric alcohol (for example propylene glycol, two poly-dihydric alcohols or trihydroxylic alcohol) and/ester of Guerbet alcohol formation, based on C
6-10The triglyceride of fatty acid is based on C
6-18The list of fatty acid-/two-/the triglyceride liquid mixture, C
6-22The ester that aliphatic alcohol and/or Guerbet alcohol and aromatic carboxylic acids (especially benzoic acid) form, C
2-12Dicarboxylic acids and the straight or branched C that contains 1 to 22 carbon atom
6-22Aliphatic alcohol or contain the ester that the polyhydroxy-alcohol of 2 to 10 carbon atoms and 2 to 6 hydroxyls forms, vegetable oil, branched-chain primary alcohol, the cyclohexane extraction of replacement, straight chain and side chain C
6-22The aliphatic alcohol carbonic ester, Guerbet carbonic ester, benzoic acid and straight or branched C
6-22Aliphatic alcohol (Finsolv for example
TN) ester of Xing Chenging, straight or branched, symmetry or dialkyl ether asymmetric, that each alkyl contains 6 to 22 carbon atoms, the opened loop compound of epoxy aliphatic ester and polyhydroxy-alcohol, silicone oil and/or aliphatic hydrocarbon or cycloalkane, for example squalane, Squalene or dialkyl cyclohexane extraction.
The addition compound product of oxirane and/or expoxy propane and aliphatic alcohol, fatty acid, alkylphenol or Oleum Ricini is known product that can be commercially available.They are homology mixture, and its average extent of alkoxylation meets oxirane and/or expoxy propane and will carry out ratio between the substrate of additive reaction.The C of the addition compound product of oxirane and glycerol
12-18Fatty-acid monoester and diester are the heavy fatting agents (refatting agents) in the known cosmetic formulations.
The exemplary of suitable partial glyceride is the hydroxy stearic acid monoglyceride, hydroxy stearic acid two glyceride, the isostearic acid monoglyceride, isostearic acid two glyceride, monoolein, oleic acid two glyceride, the castor oil acid monoglyceride, castor oil acid two glyceride, Sunsoft 8090, linoleic acid two glyceride, Sunsoft 8090, linoleic acid two glyceride, the erucic acid monoglyceride, erucic acid two glyceride, the tartaric acid monoglyceride, tartaric acid two glyceride, the citric acid monoglyceride, citric acid two glyceride, the malic acid monoglyceride, malic acid two glyceride and wherein may still contain on a small quantity artificial mixt from the triglyceride of production process.1 to 30, preferred 5 to the 10 moles oxirane and the addition compound product of above-mentioned partial glyceride also are suitable.
Greasy exemplary is a glyceride, it is animals and plants product solid or liquid (being often referred to oil in this case), that form by the glyceride mixing of higher fatty acids basically, suitable wax is other native paraffin, for example candelilla wax, Brazil wax, Japan wax, esparto wax, cork wax, guaruma wax, rice embryo oil wax, sugarcane wax, ouricury wax, lignite wax, Cera Flava, shellac wax, spermaceti, lanoline (lanocerin), tail fat, ceresin, ceresine (ceresine), vaseline, paraffin, microwax; Chemical modification wax (hard wax) for example covers red ester type waxes, sasol wax, hydrogenation Jojoba haze tallow and synthetic wax, for example polyolefin-wax and polyethylene glycol wax.Except that oils and fats, similar greasy material also is suitable additive, for example lecithin and phospholipid.For those of ordinary skills, term " lecithin is those glycerophosphates that formed through esterification by fatty acid, glycerol, phosphoric acid and choline.Therefore for the professional, lecithin also is often referred to phosphatidylcholine (PC).The example of the natural phosphatidyl choline that can mention is a cephalin, and it also refers to phosphoric acid and 1,2-diacyl-sn-glycerol-3-phosphate derivant.By relatively, normally the list that forms of phosphoric acid and glycerol-and preferably, diester (glycerophosphate) generally is considered as oils and fats with it to term " phospholipid ".In addition, sphingol and sphingolipid also are suitable.
Addible suitable pearlescent waxes is, for example alkylene glycols ester, particularly glycol distearate; Marlamid, particularly coconut fatty acid diethanolamine; Partial glyceride, particularly glycerol monostearate; Polynary ester can be chosen the ester that hydroxyl carboxylic acid that replaces and the aliphatic alcohol that contains 6 to 22 carbon atoms form wantonly, particularly tartaric long-chain ester; Fats compound, for example aliphatic alcohol, aliphatic ketone, fatty aldehyde, fatty ester and contain the aliphatic carbonate ester that is no less than 24 carbon atoms, particularly laurone and distearyl altogether; Fatty acid, for example stearic acid, hydroxy stearic acid or behenic acid; The olefin epoxide that contains 12 to 22 carbon atoms with contain the aliphatic alcohol of 12 to 22 carbon atoms and/or contain open loop product that the polyhydroxy-alcohol of 2 to 15 carbon atoms and 2 to 10 hydroxyls forms with and composition thereof.
The superfatting agent that adds preparation can be following material: lanoline for example lanoline and lecithin and polyethoxylated or acidylate and lecithin derivant, and the polyhydroxy-alcohol fatty acid ester, monoglyceride and Marlamid, the latter is also as foam stabiliser.
The cationic polymer that can add is that for example cationic cellulose derivative is (for example from Amerchol Polymer JR400 by name
Quaternary ammoniated hydroxyethyl-cellulose), cationic starch, the copolymer of two allyl ammonium salts and acrylamide, quaternary ammoniated vinylpyrrolidone/ethylene imidazoles polymer (Luviquat for example
(BASF)), the condensed products of polyglycols and amine, quaternary ammoniated collagen polypeptide, for example lauryl dimethyl ammonium hydroxypropyl hydrolytic collagen (Lamequat
L, Gr ü nau), quaternary ammoniated Semen Tritici aestivi polypeptide, poly-Ethylenimine, cation silicone polymer, polydimethylsiloxane ammonia (amodimethicone) for example, the copolymer (Cartaretine of ethanedioic acid and dimethylamino hydroxypropyl diethylentriamine
, Sandoz), the copolymer (Merquat of acrylic acid and dimethyl diallyl ammonium chloride
550, Chemviron), poly-amino polyamide and its cross-linked, water-soluble polymer, the cation chitin derivative, for example quaternary ammoniated chitosan, optional condensed products with crystallite distribution, dihalo hydrocarbon (for example dibromobutane) and two-dialkylamine, for example Bis-dimethylamino 1,3-propane, cationic guar gum, for example Jaguar of Celanese
CBS, Jaguar
C-17 and Jaguar
C-16, quaternary ammoniated ammonium salt polymer, for example Mirapol of Miranol
A-15, Mirapol
AD-1 and Mirapol
AZ-1.
The suitable cation that can add, amphion, both sexes and non-ionic polymers are: vinyl acetate/.beta.-methylacrylic acid copolymer for example, vinyl pyrrolidone/vinyl acrylate copolymer, vinyl acetate/maleic acid butyl ester/isobornyl acrylate copolymer, ethylene methacrylic ether/maleic anhydride copolymers and its ester, uncrosslinked and the crosslinked acrylic acid of polyhydroxy, acrylamido propyl group chlorination trimethylammonium/acrylate copolymer, octyl acrylamide/methyl methacrylate/methacrylic acid uncle fourth amino ester/methacrylic acid 2-hydroxy propyl ester copolymer, polyvinylpyrrolidone, vinyl pyrrolidone/vinyl acetate copolymer, any derivant of vinyl pyrrolidone/dimethylaminoethyl methacrylate/caprolactam terpolymer and cellulose ether and silicone.
Suitable silicone chemical compound is, dimethyl polysiloxane for example, methyl phenyl silicone, ring-type silicone and amino-, fatty acid-, alcohol-, polyethers-, epoxy-, fluoro-, glucoside-and/or silicone chemical compound of modifying of alkyl, these materials at room temperature are liquid or similar resinoid.Other suitable silicone chemical compound is dimethione (simethicone), and it is that average chain length is the dimethicone of 200 to 300 dimethyl siloxane units and the mixture of hydrogenated silicate.
Preparation of the present invention can further contain the UV protection factor of appropriate amount, source of students agent, for example tocopherol, tocopherol acetate, Palmic acid tocopherol, ascorbic acid, deoxyribonucleotide, retinol, bisabolol, allantoin, phytane triketone, pantothenylol, AHA acid, aminoacid, ceramide, pseudo-neural amide, quintessence oil, plant extract and vitamin complex; Deodorizer, plumule inhibitor, enzyme inhibitor, abnormal flavour absorbent, these materials can absorb or a large amount of chemical compound that produces abnormal flavour of keeping somewhere; The film forming agent, extender, for example carbopol (Goodrich) of Pemulen and alkyl modification.
Solubilizing agent or hydrotrote be, for example ethanol, isopropyl alcohol or polyhydric alcohol.
Suitable antiseptic can be anyly to instruct the antiseptic of addressing among (European CosmeticDirective) appendix VI in European face-lifting, comprising: for example phenoxyethanol, Liquor Formaldehyde, p-Hydroxybenzoate, glutaraldehyde or sorbic acid etc.
Suitable aromatic oil is natural and mixture synthetic aromatising agent.The natural aromatic agent comprises colored extract (Bulbus Lilii, Garden lavender, Flos Rosae Rugosae, jasmine, orange blossom oil, the fragrant cananga), extract (the Oleum Pelargonii Graveolentis of stem and leaf, Herba Pogostemonis, the bergamot leaf), extract (the Pimpinella anisum Linn. of fruit, Herba Coriandri, Herba Coriandri, Juniperus oxycedrus), extract (the bergamot of peel, Fructus Citri Limoniae, orange), extract (the Semen Myristicae of root, Radix Angelicae Sinensis, Herba Apii graveolentis, Fructus Amomi Rotundus, the Radix Aucklandiae, Rhizoma Iridis Tectori, Rhizoma Acori Graminei), extract (the Masson Pine of xylem, sandalwood, guaiaci lignum, cedar wood, redwood), herbaceous plant and careless extract (tarragon, Herba Cymbopogonis Citrari, Salvia japonica Thunb., Herba thymi vulgaris), extract (the PiceameyeriRehd. Et Wils. of needle or branch, fir, pinaster, Pinus mugo), the extract (galbanum of resin and face cream, Canarium luzonicum Elemi, Benzoinum, Myrrha, Olibanum, opopanax).The original material of animal (for example civetta and beaver) also is available.Typical synthesizing fragrant immunomodulator compounds is the product of ester, ether, aldehyde, ketone, pure and mild hydrocarbon types.The example of ester type aromatic chemical compound is which ester, benzyl formate, ethyl methyl phenyl aminoacetate, acrylic cyclohexylpropionic acid ester, styralyl propionate and a bigcatkin willow acid benzyl ester in benzyl acetate, benzene oxygen ethyl isobutyl ester, p-tert-butylcyclohexyl acetas, linalyl acetate, dimethyl benzyl carbonyl (carbinyl) acetas, phenylethyl acetas, the benzoic acid.The ether type comprises, benzylisoeugenol for example, and aldehydes comprises, for example contains the clean big vast aldehyde of straight chain alkanal, citric acid, citronellal, citronellyl oxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilestralis and ripple (bourgeonal) of 8 to 18 carbon atoms.The example of suitable ketone is ionone, α-different methyl ionone and vertofix coeur.Suitable alcohols is anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, the pure and mild terpinol of phenylethyl.Hydro carbons mainly comprises terpenoid and face cream.Yet preferably use the mixture of distinct fragrance immunomodulator compounds together, this can produce a kind of pleasant fragrance.
Suitable stain be anyly be suitable for, and the verified listed material of purpose that is used to make up.
Preparation of the present invention has reduced the content of anion surfactant, but still good frothing capacity can be provided.In addition, the total content of the surfactant of preparation of the present invention is lower, but the cleaning of preparation and frothing capacity is not produced harmful effect.This helps further to reduce zest and says more attractive from economic angle.Preparation of the present invention has good tolerability and is specially adapted to the baby and the skin of sensitivity.Said preparation can specifically be allocated the shampoo that reduces the eyes sensation of pricking into.
Preparation of the present invention has outstanding foaming and cleaning capacity, and because its soft property is highly suitable for skin.
The following example is used for further specifying the present invention, and unrestricted its scope.All percentage rate relevant with composition all are the weight ratios with respect to the total formulation weight amount in these embodiments.
Embodiment 1
％
Cocos nucifera oil glucoside 5.0%
Cocos nucifera oil both sexes sodium acetate 4.41%
Polyethyleneglycol sodium lauryl tri(oxyethyl) sulfate 4.0%
Poly-quaternary amine-10 (Polyquaternium-10) 0.20%
Hydroxypropyl trimethylammonium 0.60%
-(Hydroxypropyltrimonium-) hydrolysis is little
Aleuronat
Water 81.245%
EDTA four sodium (86%) 0.065%
Glycerol (100%) 0.500%
Phenoxyethanol 0.80%
Methyl parahydroxybenzoate 0.165%
Citric acid (35%)/water (65%) 0.45%
PEG 150 distearates 0.14%
PEG-4 Semen Allii Tuberosi amide (100%) 0.50%
Flavouring agent 0.15%
PEG 80 sorbitan monolaurates (＞70%) 0.80%
Butyl carbamic acid-iodo-propynyl ester (10%)/0.04%
PEG-4 (10%)/PEG-4 laurate
(40%)/PEG-4 distearate (40%)
Stain 1.00%
Total amount 100%
At first mixed surfactant adds conditioner (poly-quaternary amine-10 and the hydrolyzed wheat protein) mixture that places water on this basis.Then other composition is added by its listed order.
Embodiment 2
Water 84.96%
Cocos nucifera oil glucoside 4.10%
Laurel both sexes sodium acetate 3.29%
Polyethyleneglycol sodium lauryl tri(oxyethyl) sulfate 2.98%
Poly-quaternary amine-10 (Polyquaternium-10) 0.090%
EDTA four sodium (86%) 0.065%
Glycerol (100%) 0.500%
Phenoxyethanol 0.80%
Methyl parahydroxybenzoate 0.165%
Citric acid (35%)/water (65%) 0.45%
PEG150 distearate 0.14%
PEG-4 Semen Allii Tuberosi amide (100%) 0.50%
Flavouring agent 0.15%
PEG 80 sorbitan monolaurates (＞70%) 0.80%
Butyl carbamic acid-iodo-propynyl ester 0.04%
(10%)/PEG-4 (10%)/PEG-4 laurate
(40%)/PEG-4 distearate (40%)
Stain 1.00%
Total amount 100%
At first mixed surfactant adds conditioner (poly-quaternary amine-10) on this basis.Then other composition is added by its listed order.
Embodiment 3
The external model that the eye that damages as the permeability barrier based on corneal epithelial tissue with transdermal penetration (TEP) test stimulates.This permeability barrier is formed by the firm connection and the desmosome of outermost cellular layer.
When stimulus object contacted with corneal epithelial tissue, one of situation of Fa Shenging was because the permeability barrier is lost in the firm separation that connects at first, the seepage but epithelial tissue becomes, and make the substrate under it be exposed to stimulus object and finally cause cell separation.The liquid that is sucked can cause the substrate expansion to separate with collagen layer, finally causes nebula.
In the firm epithelial cell line that is connected the several good foundation that comprise mdck cell discovery is arranged all.The confluent monolayer that is grown in the mdck cell on the micropore insert has higher resistive not allow fluorescein sodium pass through film.The mdck cell confluent monolayer is as functional complete epithelial tissue.After handling with shampoo, it is to take place in the relevant mode of dosage that ohmic forfeiture leaks out in the low hole with fluorescein sodium by film.
Method
The TEP test:
1.MDCK cell is by 1 * 10
5Cells/well is inoculated in Transwell
TMInsert sheet
2.MDCK cell growth on the 0.4 μ m pore membrane that inserts sheet surpasses 48 hours to converging
3. insert sheet and wash, place 24 orifice plates fresh, that 1000 μ lHBSS are contained in every hole then with HBSS
4. the 200 μ l test shampoo with the HBSS dilution adds each insertion sheet
Monolayer be exposed to the test shampoo in 15 minutes
6. insert sheet and wash, place 24 orifice plates fresh, that 1000 μ lHBSS are contained in every hole then with HBSS
7.200 adding each, 0.02% fluorescein sodium of μ l inserts sheet
8. the amount that leaks out to the fluorescein sodium in the low hole is measured the Eye testing of revising with spectrophotometric (492nm) method:
1. in the eyes of a rabbit, add the pure shampoo of 100 μ l every day, carried out 3 days
2. according to the Draize marking system eyes are checked when 1 hour, 24 hours, 48 hours, 96 hours after instiling first and 7 days
3. based on the per 6 external cornea classifications of merely hitting the number of animals that shows the reaction of positive cornea:
The animal situation of classification eyes muddiness is described
10 is slight
21 slight/moderates
3 2-3 moderates
4 4-5 moderates/serious
56 is serious
Data analysis
The absorption reading is carried out probability analysis obtain EC
50Value.Calculate EC from 2 or 3 tests
50The meansigma methods of value is also mapped to the various compositions in the Eye testing of revising:
With the various compositions EC relatively in the Eye testing of revising
50Logarithm:
| PCR | The animal number of cornea reaction is represented with percentage rate in per 6 rabbits |
| J﹠amp; J | To be described in the basis that is classified as in the Eye testing of revising |
| MASC | During estimating in 7 days to the maximum cornea scores of all 6 rabbits.The meansigma methods of testing in all bodies |
| MASCJ | During estimating in 7 days to the maximum conjunctiva scores of all 6 rabbits.The meansigma methods of testing in all bodies |
| MADS | During estimating in 7 days to the maximum day scores of all 6 rabbits.The meansigma methods of testing in all bodies |
To in the body of 39 kinds of preparations and vitro data
Dependency
The variable correlation coefficient
PCR 0.81
J﹠amp; J classification 0.78
MASC 0.75
MASJ 0.68
MADS 0.66
The prediction that corneal stimulates
EC
50The preparation of (be expressed as ' TEP＞2.00 ') can be predicted as the stimulus object that is lower than moderate according to TEP greater than 2%.EC
50Preparation less than 2% can be predicted as moderate or be higher than the stimulus object of moderate according to TEP.
Cutoff value with 2% has 21 kinds correctly to be predicted as and to be higher than the moderate stimulus object in 41 kinds of preparations.4 kinds are incorrectly predicted as moderate or are higher than the moderate stimulus object, also have 17 kinds correctly to be predicted as and to be lower than the moderate stimulus object.
Use these results, the positive predictive value (PV+) of TEP test is that 100% negative predictive value (PV-) is 81%.
In above-mentioned TEP test method, use the preparation of embodiment 1 and 2, find the EC of two kinds of preparations
50All greater than 2% (TEP value＞2.00).
Claims (17)
1. foaming skin care formulation that contains surfactant system, described surfactant system comprises:
(a) one or more alkyl or alkenyl oligomerization glucoside,
(b) one or more amphoteric surfactantes and
(c) one or more anion cosurfactants;
The weight ratio of described alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.1: 1 to 10: 1, and the transdermal penetration of wherein said preparation (TEP) value is equal to or greater than 1.95.
2. foaming skin care formulation that contains surfactant system, described surfactant system comprises:
(a) one or more alkyl or alkenyl oligomerization glucoside,
(b) one or more amphoteric surfactantes and
(c) one or more anion cosurfactants;
The weight ratio of described alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.1: 1 to 10: 1, and the total concentration of wherein said beet alkali surface activator is no more than 2 weight %.
3. preparation as claimed in claim 2, wherein, the total concentration of described beet alkali surface activator is no more than 1.5%, preferably is no more than 1 weight %, more preferably is substantially free of betanin.
4. as each described preparation among the claim 1-3, wherein, described preparation contains one or more alkyl or the alkenyl oligomerization glucoside of have an appointment 2 weight % or preferred 3 weight % at least.
5. preparation as claimed in claim 1, wherein, described preparation contains surfactant system, and this system comprises:
(a) one or more alkyl or alkenyl oligomerization glucoside;
(b) one or more are selected from down the amphoteric surfactant of group: both sexes alkanoate, both sexes two alkanoates, amino-alkane acid esters and imino group alkanoate;
(c) one or more anion cosurfactants.
6. as each described preparation among the claim 2-5, its TEP value is equal to or greater than about 1.95.
7. as each described preparation among the claim 1-6, wherein, the total concentration of described anion surfactant with respect to the gross weight of preparation for being lower than 5 weight %.
8. as claim 1 or 7 described preparations, wherein, the weight ratio of described alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.5: 1 to 10: 1.
9. preparation as claimed in claim 8, wherein, the total concentration of described surfactant ((a)+(b)+(c)) is 0.1 to 20 of a total formulation weight amount, preferably 1 to 15, more preferably in 5 to 13 weight % scopes.
10. preparation as claimed in claim 1, it contains:
(a) the alkyl oligomerization glucoside of 0.1 to 20 weight %,
(b) amphoteric surfactant of 0.1 to 20 weight % and
(c) the anion cosurfactant of 0.1 to 20 weight %;
The weight ratio of described alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.1: 1 to 10: 1, and adds other suitable composition amount is supplied 100%.
11. preparation as claimed in claim 10, it contains:
(a) the alkyl oligomerization glucoside of 1 to 10 weight %,
(b) amphoteric surfactant of 1 to 10 weight % and
(c) the anion cosurfactant of 1 to 10 weight %;
The weight ratio of described alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 1.5: 1 to 5: 1, and adds other suitable composition amount is supplied 100%.
12. preparation as claimed in claim 11, it contains:
(a) the alkyl oligomerization glucoside of 2 to 10 weight %,
(b) amphoteric surfactant of 2 to 10 weight % and
(c) the anion cosurfactant of 2 to 5 weight %;
The weight ratio of described alkyl androstanediol and amphoteric surfactant and anion cosurfactant [(a+b): c] is 2: 1 to 3: 1, and adds other suitable composition amount is supplied 100%.
13. preparation as claimed in claim 12, it contains:
(a) the alkyl oligomerization glucoside of 5 to 10 weight %,
(b) amphoteric surfactant of 5 to 10 weight % and
(c) the anion cosurfactant of 2 to 5 weight %;
And the weight ratio of wherein said surfactant (alkyl androstanediol than amphoteric surfactant than anion cosurfactant) [a: b: c] is (1.0 to 1.5): (1.0 to 1.3): 1.
14. as any one described preparation among the claim 1-13, wherein, described amphoteric surfactant is selected from: both sexes alkanoate, both sexes two alkanoates, amino-alkane acid esters and imino group alkanoate.
15. as any one described preparation among the claim 1-13, wherein, described amphoteric surfactant is selected from: alkyl or alkenyl both sexes acetate, alkyl or alkenyl both sexes diacetin, alkyl or alkenyl both sexes propionate or alkyl or alkenyl both sexes dipropionate.
16. as any one described preparation among the claim 1-13, wherein, described amphoteric surfactant is selected from: alkyl both sexes acetate or diacetin, alkyl both sexes propionate or dipropionate,
17. preparation as claimed in claim 16, wherein, described alkyl is lauryl or cocoyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03075677.9 | 2003-03-07 | ||
| EP03075677 | 2003-03-07 |
Publications (1)
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|---|---|
| CN1756526A true CN1756526A (en) | 2006-04-05 |
Family
ID=32946901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004800059230A Pending CN1756526A (en) | 2003-03-07 | 2004-03-08 | Low irritation lathering formulations |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1601341A1 (en) |
| JP (1) | JP2006519808A (en) |
| KR (1) | KR20050120635A (en) |
| CN (1) | CN1756526A (en) |
| AU (1) | AU2004216853A1 (en) |
| BR (1) | BRPI0408144A (en) |
| CA (1) | CA2518213A1 (en) |
| MX (1) | MXPA05009571A (en) |
| WO (1) | WO2004078159A1 (en) |
Cited By (1)
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|---|---|---|---|---|
| CN102596162A (en) * | 2009-08-03 | 2012-07-18 | 因诺斯佩克有限公司 | Composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1716842B1 (en) * | 2005-04-30 | 2008-12-24 | Cognis IP Management GmbH | Mild cleansing compositions |
| JP4918327B2 (en) * | 2006-10-16 | 2012-04-18 | 株式会社ナリス化粧品 | Cleansing composition |
| DE102008038137A1 (en) | 2008-08-18 | 2010-02-25 | Henkel Ag & Co. Kgaa | Sulfate-free mild surfactant system for skin and hair cleansing |
| DE102013208056A1 (en) | 2013-05-02 | 2014-11-06 | Henkel Ag & Co. Kgaa | Care shampoo |
| KR102611523B1 (en) * | 2016-10-25 | 2023-12-07 | (주)아모레퍼시픽 | Composition for hair care |
| WO2020029223A1 (en) * | 2018-08-10 | 2020-02-13 | Beiersdorf Daily Chemical (Wuhan) Co. Ltd. | A foamable cleansing composition |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9008944D0 (en) * | 1990-04-20 | 1990-06-20 | Unilever Plc | Shampoo composition |
| TR26415A (en) * | 1990-09-21 | 1995-03-15 | Procter & Gamble | SOFT SAMPUAN COMPOSITIONS |
| DE4435387C2 (en) * | 1994-10-04 | 1997-08-14 | Henkel Kgaa | Pumpable aqueous surfactant concentrates |
| GB2303637B (en) * | 1995-07-21 | 1999-04-21 | Cussons Int Ltd | Personal cleaning composition |
| DE69714016T2 (en) * | 1996-01-29 | 2003-03-13 | Johnson & Johnson Consumer Companies, Inc. | DETERGENT COMPOSITIONS |
| US6808701B2 (en) * | 2000-03-21 | 2004-10-26 | Johnson & Johnson Consumer Companies, Inc. | Conditioning compositions |
-
2004
- 2004-03-08 MX MXPA05009571A patent/MXPA05009571A/en not_active Application Discontinuation
- 2004-03-08 BR BRPI0408144-7A patent/BRPI0408144A/en not_active Application Discontinuation
- 2004-03-08 CA CA002518213A patent/CA2518213A1/en not_active Abandoned
- 2004-03-08 WO PCT/EP2004/002498 patent/WO2004078159A1/en not_active Application Discontinuation
- 2004-03-08 JP JP2006504637A patent/JP2006519808A/en not_active Withdrawn
- 2004-03-08 EP EP04718306A patent/EP1601341A1/en not_active Withdrawn
- 2004-03-08 KR KR1020057016630A patent/KR20050120635A/en not_active Application Discontinuation
- 2004-03-08 AU AU2004216853A patent/AU2004216853A1/en not_active Abandoned
- 2004-03-08 CN CNA2004800059230A patent/CN1756526A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596162A (en) * | 2009-08-03 | 2012-07-18 | 因诺斯佩克有限公司 | Composition |
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| Publication number | Publication date |
|---|---|
| JP2006519808A (en) | 2006-08-31 |
| EP1601341A1 (en) | 2005-12-07 |
| AU2004216853A1 (en) | 2004-09-16 |
| MXPA05009571A (en) | 2005-10-19 |
| WO2004078159A1 (en) | 2004-09-16 |
| KR20050120635A (en) | 2005-12-22 |
| BRPI0408144A (en) | 2006-03-01 |
| CA2518213A1 (en) | 2004-09-16 |
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