CN1754519A - Method for controlling orthopaedic gypsum constituent operation time and its constituent - Google Patents
Method for controlling orthopaedic gypsum constituent operation time and its constituent Download PDFInfo
- Publication number
- CN1754519A CN1754519A CN 200410080251 CN200410080251A CN1754519A CN 1754519 A CN1754519 A CN 1754519A CN 200410080251 CN200410080251 CN 200410080251 CN 200410080251 A CN200410080251 A CN 200410080251A CN 1754519 A CN1754519 A CN 1754519A
- Authority
- CN
- China
- Prior art keywords
- semi
- gypsum
- hydrated gypsum
- water solution
- weight ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a method for controlling the operating time for the composition of the plaster used in orthopaedics and the composition of the plaster used in orthopaedics, comprising: mixing the semi-hydrated gypsum, water solution and hyaluronic acid, stirring homogenously to form the semi-solidification condition and getting the injection plaster used in orthopaedics, the essence proportion by weight between the semi-hydrated gypsum and water solution is 40:11 to 40:13, and the essence proportion by weight between the semi-hydrated gypsum and hyaluronic acid is 500:1 to 200:3.
Description
Technical field
The present invention is relevant a kind of method and gypsum composition for department of orthopedics of controlling the gypsum composition for department of orthopedics operating time.
Background technology
As bone substituent (bone substituent), be the medical circle known technology with semi-hydrated gypsum, but then be emerging technology, for example No. 6251139 patent of the U.S. as pouring-in bone substituent.This emerging technology main difficulty is that the operating time (working time) of orthopaedic gypsum and half setting time (semi-solidification time) are wayward.The so-called herein operating time means from semi-hydrated gypsum and aqueous solution, to can't (or extremely difficult) mixed gypsum composition for department of orthopedics being extruded required time by injection tube; And so-called half setting time is meant from semi-hydrated gypsum and group water solution and mixes, extremely gypsum composition for department of orthopedics is inserted in the group water solution (for example normal saline solution or body fluid), this gypsum composition for department of orthopedics can not swoon hold or scatter till required time.Traditional gypsum composition for department of orthopedics, its half setting time and the scope of operating time are rather narrow, for example half setting time is 2.5 to 3 minutes, and the operating time is 3.5 to 4 minutes, also be about to after semi-hydrated gypsum and the aqueous solution in 2.5 minutes, be injected in the body fluid, this gypsum composition for department of orthopedics can scatter; Mix the back and injected in 2.5 to 3 minutes, can not guarantee can not scatter; Mix the back and injected in 3.5 to 4 minutes,, can not guarantee and to inject fully though can not scatter; Mix after 4 minutes, this gypsum composition for department of orthopedics can't inject human body, that is only injection in 3 to 3.5 minutes after mixing, can guarantee that just this gypsum composition for department of orthopedics can reach optimum efficiency.Because the time range that is suitable for injecting is short, and it is pressed for time, causes the medical circle acceptance low.Therefore, the operating time and/or half setting time of control gypsum composition for department of orthopedics are a key technology.
Summary of the invention
The present invention is outside semi-hydrated gypsum and group water solution, adds an amount of hyaluronic acid, with the operating time and half setting time of control gypsum composition for department of orthopedics.
A purpose of the present invention is to provide a kind of method of controlling the gypsum composition for department of orthopedics operating time.
Another object of the present invention is to provide a kind of gypsum composition for department of orthopedics.
A further object of the present invention is to provide the gypsum composition for department of orthopedics of a kind of energy control operation time and/or half setting time.
Another purpose of the present invention is to provide a kind of hyaluronic gypsum composition for department of orthopedics that contains.
Embodiment
The method of control gypsum composition for department of orthopedics operating time of the present invention, it comprises: semi-hydrated gypsum, hyaluronic acid and group water solution are mixed, and evenly stir, partly solidify shape to form, as pouring-in orthopaedic gypsum, wherein the weight ratio of this semi-hydrated gypsum and this group water solution is essentially 40: 11 to 40: 13, and this semi-hydrated gypsum and this hyaluronic weight ratio are essentially 500: 1 to 200: 3.
Above-mentioned so-called the stirring is to make a general reference to make the mixed uniformly method of semi-hydrated gypsum and group water solution, program or step arbitrarily, for example stirs with splash bar, closes sheet and stirs up and down to stir, and rotates with magnetic stick, rotates ultrasound vibration etc. with stirring vane.
Above-mentioned semi-hydrated gypsum and group water solution weight ratio are 40: 11 to 40: 13, if the semi-hydrated gypsum consumption is too high, then are difficult for forming evenly semi-solid (semi-solid), can't form suitable plaster block; If the semi-hydrated gypsum consumption is low excessively, the undercapacity of then formed Gypsum Fibrosum block, even can't be fixed in body fluid.
Above-mentioned group water solution, it can be essentially pure water, and for example distilled water, deionized water or reverse osmosis water also can be known medical aqueous solution, and for example normal saline solution is preferable with known medical aqueous solution, is best with the normal saline solution.
Above-mentioned hyaluronic acid is meant generalized hyaluronic acid, such as commercially available hyaluronic acid.And commercially available hyaluronic acid is meant hyaluronic acid (hyaluronic acid) or its esters (hyaluronates), or its mixture.So-called hyaluronate, for example hyaluronate sodium (sodium hyaluronate), potassium hyaluronate (potassiumhyaluronate).
Above-mentioned semi-hydrated gypsum and hyaluronic weight ratio are essentially 500: 1 to 200: 3, are preferable with 1000: 3 to 100: 1, with 250: 1 to 500: 3 for better.
Certainly, based on the demand of given efficacy (for example promoting osteocyte to increase antiinflammatory or other curative effect), this gypsum composition for department of orthopedics may must contain specific material.If should (these) material be solid material, with prior and this semi-hydrated gypsum mix homogeneously, or make that to be dissolved in this group water solution fully be preferable, if should (these) material be liquid material, then to dissolve in advance in this group water solution for preferable, certainly, also can be before semi-hydrated gypsum and group water solution mix/simultaneously or/add uniform mixing more afterwards.
The present invention controls the method meaning of gypsum composition for department of orthopedics operating time and can revise as follows by a small margin: make to contain hyaluronic group water solution, mix and evenly stirring with semi-hydrated gypsum, partly solidify shape to form, as pouring-in orthopaedic gypsum, wherein the weight ratio of this hyaluronic acid in group water solution is 1: 150 to 1: 20, and this semi-hydrated gypsum and this weight ratio that contains hyaluronic group water solution are essentially 40: 11 to 40: 13.
Because the water-soluble based sols speed of hyaluronic acid is unhappy, so the present invention makes the water-soluble based sols of hyaluronic acid in advance.Generally speaking, its effect is better than the above-mentioned direct blended mode of semi-hydrated gypsum, hyaluronic acid and group water solution that makes.
The weight ratio of above-mentioned this hyaluronic acid in group water solution is 1: 150 to 1: 20, is preferable with 1: 100 to 1: 30, and 1: 75 to 1: 50 for better.
The definition of so-called herein semi-hydrated gypsum, hyaluronic acid, group water solution etc. is all as above-mentioned.And gypsum composition for department of orthopedics of the present invention still can add certain drug or constituent also as described above according to need.
Gypsum composition for department of orthopedics of the present invention, it contains:
Semi-hydrated gypsum;
Group water solution; And
Hyaluronic acid;
Wherein the weight ratio of this semi-hydrated gypsum and group water solution is essentially 40: 11 to 40: 13, and semi-hydrated gypsum and hyaluronic weight ratio are essentially 500: 1 to 200: 3.
Wherein semi-hydrated gypsum, group water solution and hyaluronic acid can mix use in fact simultaneously; But also behind the prior mix homogeneously of group water solution and hyaluronic acid, mix with semi-hydrated gypsum again.
The definition of so-called herein semi-hydrated gypsum, hyaluronic acid, group water solution etc., its mutual relation, weight when or volumetric ratio etc. all as above-mentioned, and gypsum composition for department of orthopedics of the present invention still can add certain drug or constituent also as described above according to need.
For further specifying the present invention, be described as follows with embodiment now, only these embodiment are not in order to restriction claim of the present invention.
The specific embodiment
Comparative example 1～10:
With semi-hydrated gypsum (available from U.S. Baker company), normal saline solution and hyaluronic acid (it is measured as table 1), in 20 milliliters injection tube, mix.With 316 rustless steel splash bars (long 150mm, diameter 1.0mm), evenly stir, survey its operating time and half setting time, result such as table 1.
Table 1: used unit is respectively in the table: semi-hydrated gypsum (gram), normal saline solution (milliliter), hyaluronic acid (milligram), operating time (minute), half setting time (minute).
| Embodiment | Semi-hydrated gypsum | Saline solution | Hyaluronic acid | Half setting time | Operating time |
| 1 | 10 | 3.0 | 15 | 3.5 | -5.0 |
| 2 | 10 | 3.0 | 20 | 3.5 | 7.0 |
| 3 | 10 | 3.0 | 30 | 4.0 | 8.0 |
| 4 | 10 | 3.0 | 40 | 4.0 | 10.0 |
| 5 | 10 | 3.0 | 50 | 4.0 | 12.0 |
| 6 | 10 | 3.0 | 60 | 4.5 | 12.5 |
| 7 | 10 | 3.0 | 80 | 4.5 | 14.0 |
| 8 | 10 | 3.0 | 100 | 4.5 | 17.5 |
| 9 | 10 | 3.0 | 150 | 5.0 | 25.5 |
| 10 | 10 | 3.0 | 200 | 6.0 | ＞40 |
Embodiment 11～17:
Roughly the same embodiment 1, but aqueous solution and hyaluronic consumption change as table 2, and the result is referring to table 2:
Table 2: applying unit is with table 1
| Embodiment | Saline solution | Hyaluronic acid | Half setting time | Operating time |
| 11 | 2.7 | 50 | 2.0 | 3.5 |
| 12 | 2.8 | 50 | 2.5 | 6.0 |
| 13 | 2.9 | 50 | 4.0 | 7.5 |
| 14 | 3.0 | 50 | 4.0 | 10.0 |
| 15 | 3.1 | 50 | 4.0 | 14.0 |
| 16 | 3.2 | 50 | 4.0 | 19.0 |
| 17 | 3.3 | 50 | 4.0 | ＞40 |
Embodiment 18～20
Roughly the same embodiment 13～15, but replace normal saline solution with water, and make hyaluronic acid soluble in water in advance, wherein water and hyaluronic acid consumption and experimental result such as table 3.
Table 3: applying unit is with table 1
| Embodiment | Water | Hyaluronic acid | Half setting time | Operating time |
| 18 | 2.9 | 50 | 3.5 | 6.5 |
| 19 | 3.0 | 50 | 4.0 | 8.0 |
| 20 | 3.1 | 50 | 4.0 | 11.0 |
Claims (9)
1. method of controlling the gypsum composition for department of orthopedics operating time, it comprises: semi-hydrated gypsum, hyaluronic acid and group water solution are mixed, and evenly stir, partly solidify shape to form, as pouring-in orthopaedic gypsum, wherein the weight ratio of this semi-hydrated gypsum and group water solution is 40: 11 to 40: 13, and semi-hydrated gypsum and hyaluronic weight ratio are 500: 1 to 200: 3.
2. method according to claim 1, wherein this semi-hydrated gypsum and hyaluronic weight ratio are 1000: 3 to 100: 1.
3. method according to claim 2, wherein this semi-hydrated gypsum and hyaluronic weight ratio are 250: 1 to 500: 3.
4. method of controlling the gypsum composition for department of orthopedics operating time, it comprises: make to contain hyaluronic group water solution, mix and evenly stirring with semi-hydrated gypsum, partly solidify shape to form, as pouring-in orthopaedic gypsum, wherein the weight ratio of this hyaluronic acid in group water solution is 1: 150 to 1: 20, and this semi-hydrated gypsum and this weight ratio that contains hyaluronic group water solution are 40: 11 to 40: 13.
5. method according to claim 4, wherein the weight ratio of this hyaluronic acid in group water solution is 1: 100 to 1: 30.
6. method according to claim 5, wherein the weight ratio of this hyaluronic acid in group water solution is 1: 75 to 1: 50.
7. gypsum composition for department of orthopedics, it contains:
Semi-hydrated gypsum;
Group water solution; And
Hyaluronic acid;
Wherein the weight ratio of this semi-hydrated gypsum and group water solution is 40: 11 to 40: 13, and semi-hydrated gypsum and hyaluronic weight ratio are 500: 1 to 200: 3.
8. constituent according to claim 7, wherein this semi-hydrated gypsum and hyaluronic weight ratio are 1000: 3 to 100: 1.
9. constituent according to claim 8, wherein this semi-hydrated gypsum and hyaluronic weight ratio are 250: 1 to 500: 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410080251 CN1754519A (en) | 2004-09-28 | 2004-09-28 | Method for controlling orthopaedic gypsum constituent operation time and its constituent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410080251 CN1754519A (en) | 2004-09-28 | 2004-09-28 | Method for controlling orthopaedic gypsum constituent operation time and its constituent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1754519A true CN1754519A (en) | 2006-04-05 |
Family
ID=36688259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410080251 Pending CN1754519A (en) | 2004-09-28 | 2004-09-28 | Method for controlling orthopaedic gypsum constituent operation time and its constituent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1754519A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420489C (en) * | 2006-07-06 | 2008-09-24 | 天津大学 | Controllable cured calcium sulfate bone-cementing agent and its preparation method |
-
2004
- 2004-09-28 CN CN 200410080251 patent/CN1754519A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420489C (en) * | 2006-07-06 | 2008-09-24 | 天津大学 | Controllable cured calcium sulfate bone-cementing agent and its preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1085632C (en) | Concrete spraying additives | |
| TWI328569B (en) | Admixture | |
| JP3172932B2 (en) | Method for producing hydraulic composition using generated soil | |
| CN106927719B (en) | A kind of acrylates combined casting packing material and the preparation method and application thereof | |
| CN1403069A (en) | Process for producing slurry from calcium cementing agent | |
| CN1047802A (en) | Moisturing vehicle for topical application of vitamin a acid | |
| CN1754519A (en) | Method for controlling orthopaedic gypsum constituent operation time and its constituent | |
| JP4636970B2 (en) | Grout method | |
| JP2002155277A (en) | One-part plastic grout | |
| KR101132673B1 (en) | Ubiquitous Injectable, Thermo-Reversible Gel for Hydrophobic and Hydrophilic Drug Delivery | |
| CN1958080A (en) | Method for preparing injuctable material for repairing bones solidified in situ from calcium alginate | |
| CN110314101B (en) | Premixed antibacterial, fast-curing and anti-collapsibility calcium silicate-based bioactive material | |
| JP2002160955A (en) | Setting retarder for back-fill grout, back-fill grout and its grouting method | |
| JP3345680B2 (en) | Backfill injection material | |
| CN1457897A (en) | Gypsum composition for department of orthopedics | |
| JP2002332798A (en) | Continuous manufacturing device for accelerator slurry, and spraying construction method using the same | |
| CN1406636A (en) | Method and composition for control of gypsum operation time for orthopedics | |
| CN1772684A (en) | Cement early strength agent and its prepn | |
| JP3180095B2 (en) | Additive for hydraulic composition containing generated soil | |
| JP2007314725A (en) | Ground stabilizing admixture, ground stabilizing material and construction method for ground stabilization using the ground stabilizing material | |
| JP4636971B2 (en) | Grout method | |
| CN101703451B (en) | Drug release mechanism based fluorine-containing dental restorative material | |
| JP5189272B2 (en) | Ground stabilization admixture, ground stabilization material and ground stabilization method using the same | |
| JP2862195B2 (en) | Cement admixture for jet grouting method and its jet grouting method | |
| JP2544073B2 (en) | Medical and dental hardening cement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |