CN1746185A - Analog of Exendin 4 - Google Patents
Analog of Exendin 4 Download PDFInfo
- Publication number
- CN1746185A CN1746185A CN 200410054300 CN200410054300A CN1746185A CN 1746185 A CN1746185 A CN 1746185A CN 200410054300 CN200410054300 CN 200410054300 CN 200410054300 A CN200410054300 A CN 200410054300A CN 1746185 A CN1746185 A CN 1746185A
- Authority
- CN
- China
- Prior art keywords
- diabetes
- exendin
- analogues
- exendin4
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Images
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
10 * polynucleotide kinase damping fluid | 1μl |
ATP(0.1mol/L) | 1μl |
Distilled water | 3μl |
The T4 polynucleotide kinase | 1μl |
10 * ligase enzyme damping fluid | 2.5μl |
ATP(0.1mol/L) | 1μl |
The T4 ligase enzyme | 2μl |
Em32 | HGEGTFTSDLSKQ LEEEAVKLFIEWLKN PPS-OH |
HGEGTFTSDLSKQ LEEEAVKLFIEWLKN PPS-NH 2 |
The amino acid title | The source |
Fmoc-L-Ala-OH Fmoc-L-Arg(Pmc)-OH Fmoc-L-Asp(OtBu)-OH Fmoc-L-Gln(Trt)-OH Fmoc-L-Glu(OtBu)-OH Fmoc-L-Gly-OH Fmoc-L-His(Trt)-OH Fmoc-L-Ile-OH Fmoc-L-Leu-OH Fmoc-L-Lys(Trt)-OH Fmoc-L-Phe-OH Fmoc-L-Pro-OH Fmoc-L-Ser(tBu)-OH Fmoc-L-Thr(tBu)-OH Fmoc-L-Trp-OH Fmoc-L-Tyr(tBu)-OH Fmoc-L-Val-OH | Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. PE Applied.Biosystem Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. Peptide Institute,Inc. |
Title | Specification |
N-Methyl pyrrolidone methylene dichloride hexahydropyridine 2.0M DIEA/NMP DMAP/DMF is dissolved in the HBTU 100mmole/0.5M HOBT of DMF | The synthetic level of the synthetic level of polypeptide analytical pure analytical pure polypeptide synthetic level polypeptide synthetic level polypeptide |
Title | Specification |
Water trifluoroacetic acid phenol | Deionized water analytical pure analytical pure |
Mercaptoethanol methyl-phenoxide ether | Analytical pure analytical pure analytical pure |
Reagent | Consumption (ml) |
Water methyl-phenoxide phenol mercaptoethanol trifluoroacetic acid | 0.50 0.50 0.75 0.20 10.0 |
Title | Model |
Rotary Evaporators analysis mode HPLC preparation HPLC ultraviolet flow detection record | ZFQ85A LC10AD LC8A SIBAS,YOKOGAWA 3057 |
Title | Specification |
Acetonitrile | The HPLC level |
Ethanol methyl alcohol trifluoroacetic acid | HPLC level HPLC level HPLC level |
Time (min) | |
0 30 50 | 20% 60% 90% |
Equipment | Model |
The vacuum freeze drier cryogenic refrigerator | FD-5 |
Claims (14)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100543004A CN100535003C (en) | 2004-09-06 | 2004-09-06 | Analog of Exendin 4 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100543004A CN100535003C (en) | 2004-09-06 | 2004-09-06 | Analog of Exendin 4 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910159757A Division CN101643504A (en) | 2004-09-06 | 2004-09-06 | Exendin 4 analogue |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1746185A true CN1746185A (en) | 2006-03-15 |
CN100535003C CN100535003C (en) | 2009-09-02 |
Family
ID=36165925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100543004A Expired - Lifetime CN100535003C (en) | 2004-09-06 | 2004-09-06 | Analog of Exendin 4 |
Country Status (1)
Country | Link |
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CN (1) | CN100535003C (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1908778A1 (en) * | 2005-06-29 | 2008-04-09 | Changzhou Pharmaceutical Factory Co., Ltd. | Exendin 4 polypeptide fragments and use thereof |
WO2011063549A1 (en) * | 2009-11-26 | 2011-06-03 | Wu Xiaoyan | Long-acting exendin 4 analogues |
CN101280012B (en) * | 2007-03-14 | 2011-10-19 | 长春百克生物科技股份公司 | Exendin-4 active isomer and application thereof |
CN103613657A (en) * | 2013-11-28 | 2014-03-05 | 孙玉琨 | Exendin4 with shortened peptide chain and genetic engineering application thereof |
-
2004
- 2004-09-06 CN CNB2004100543004A patent/CN100535003C/en not_active Expired - Lifetime
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1908778A1 (en) * | 2005-06-29 | 2008-04-09 | Changzhou Pharmaceutical Factory Co., Ltd. | Exendin 4 polypeptide fragments and use thereof |
EP1908778A4 (en) * | 2005-06-29 | 2009-08-12 | Changzhou Pharmaceutical Facto | Exendin 4 polypeptide fragments and use thereof |
CN101280012B (en) * | 2007-03-14 | 2011-10-19 | 长春百克生物科技股份公司 | Exendin-4 active isomer and application thereof |
WO2011063549A1 (en) * | 2009-11-26 | 2011-06-03 | Wu Xiaoyan | Long-acting exendin 4 analogues |
CN102712690A (en) * | 2009-11-26 | 2012-10-03 | 吴晓琰 | Long-acting Exendin 4 analogues |
CN102712690B (en) * | 2009-11-26 | 2016-04-13 | 吴晓琰 | The analogue of long-acting Exendin 4 |
CN103613657A (en) * | 2013-11-28 | 2014-03-05 | 孙玉琨 | Exendin4 with shortened peptide chain and genetic engineering application thereof |
CN103613657B (en) * | 2013-11-28 | 2016-01-13 | 孙玉琨 | Shorten Exendin4 and the genetically engineered application thereof of peptide chain |
Also Published As
Publication number | Publication date |
---|---|
CN100535003C (en) | 2009-09-02 |
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