CN1729999A - Lactein chewing tablet and its preparing process - Google Patents
Lactein chewing tablet and its preparing process Download PDFInfo
- Publication number
- CN1729999A CN1729999A CNA2004100535474A CN200410053547A CN1729999A CN 1729999 A CN1729999 A CN 1729999A CN A2004100535474 A CNA2004100535474 A CN A2004100535474A CN 200410053547 A CN200410053547 A CN 200410053547A CN 1729999 A CN1729999 A CN 1729999A
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- lactein
- chewable tablet
- mixing
- correctives
- binding agent
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Abstract
The invention relates to a Lacidophilin chewable tablet and its preparing process, wherein the components of the chewable tablet comprises (by weight percent): Lacidophilin 5-48%, filling agent 50-92%, bonding agent 0.5-3%, and flavoring agent 0.1-1.5%.
Description
Technical field
The present invention relates to a kind of lactein, particularly relate to a kind of lactein chewable tablet and preparation method thereof.
Technical background
Lactein is a kind of digestant, is the abnormal fermentation of treatment enteral, dyspepsia, and intestinal tympanites, the improper diarrheal that causes of enteritis and pediatric diet is used medicine always.At present, the preparation of lactein has conventional tablet, powder and granule, because lactein has easy moisture absorption and meets the heavy-gravity characteristic of water, make lactein ordinary tablet easy disintegrating not in water, and powder and granule are all poor than tablet at aspects such as production, packing, transportation and stability, in addition, above-mentioned preparation is because lactein itself is very sour, and mouthfeel is very poor, and especially child's compliance is poor for patient, often refusal is taken, and does not have original therapeutic effect.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can overcome the defective that exists in the background technology, have better mouthfeel, be more suitable for the lactein chewable tablet of children taking.
Another object of the present invention provides a kind of preparation method of lactein chewable tablet.
The present invention discloses a kind of lactein chewable tablet, is made by lactein and adjuvant, and adjuvant comprises filler, binding agent and correctives; The percentage by weight of each component is in this chewable tablet: lactein 5%～48%, filler 50%～92%, binding agent 0.5%～3%, correctives 0.1%～1.5%.
Can also contain 0.1%～2% lubricant in the described chewable tablet.
Wherein said filler is one or more the mixing in sucrose, lactose, spray-dried lactose, pelletiod lactose, Lactis Anhydrous, glucose, mannitol, sorbitol, sucrose-dextrin mixture, sucrose-Nulomoline mixture, carbohydrate admixture, starch, modified starch, dextrin, maltodextrin, beta-schardinger dextrin-, calcium hydrogen phosphate two water things, calcium phosphate, calcium carbonate, microcrystalline Cellulose, the micropowder cellulose.
Binding agent is one or more the mixing in starch, gelling starch, maltose, sodium alginate, calcium ammonium alginate, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, methylcellulose, sodium carboxymethyl cellulose, ethyl cellulose, polyvinylpyrrolidone, the low-substituted hydroxypropyl cellulose.
Correctives is one or more mixing in Oleum menthae, wintergreen oil, Oleum Caryophylli, Oleum Anisi Stellati, Fructus Citri Limoniae oil, mandarin oil, menthol, strawberry essence, vanilla, grape essence, the Fructus Citri tangerinae essence.
Lubricant is one or more the mixing in magnesium stearate, calcium stearate, zinc stearate, Macrogol 4000, polyethylene glycol 6000, Stepanol MG, the adipic acid.
The invention also discloses a kind of preparation method of lactein chewable tablet: mixing after lactein, filler, binding agent are sieved respectively, system soft material, granulation, oven dry, granulate, correctives and dried granule, lubricant mixing, tabletting is promptly.
Most preferred preparation method is that lactein, filler, binding agent are crossed mix homogeneously behind 80 mesh sieves respectively, makes soft material with an amount of ethanol, the granulation of 20 mesh sieves, 60 ℃ of oven dry, 20 order granulate are with correctives and dried granule, lubricant mixing, airtight 24 hours, tabletting got final product.
Lactein chewable tablet of the present invention has mouthfeel preferably, has improved patient's compliance, especially child's compliance.
The specific embodiment
Embodiment 1: 1000 lactein chewable tablet of present embodiment preparation, use following component:
Lactein 50g
White sugar 920g
Starch 20g
Fructus Citri tangerinae quintessence oil 10g
Take by weighing each composition by above-mentioned amount, lactein, white sugar, starch are crossed mix homogeneously behind 80 mesh sieves respectively, make soft material with an amount of ethanol, the granulation of 20 mesh sieves, 60 ℃ of oven dry, 20 order granulate, Oleum menthae and dried granule mixing, airtight 24 hours, tabletting got final product.
Embodiment 2: 1000 lactein chewable tablet of present embodiment preparation, use following component:
Lactein 100g
White sugar 870g
Starch 20g
Oleum menthae 10g
Take by weighing each composition by above-mentioned amount, lactein, white sugar, starch are crossed mix homogeneously behind 80 mesh sieves respectively, make soft material with an amount of ethanol, the granulation of 20 mesh sieves, 60 ℃ of oven dry, 20 order granulate, Oleum menthae and dried granule mixing, airtight 24 hours, tabletting got final product.
Embodiment 3: 1000 lactein chewable tablet of present embodiment preparation, use following component:
Lactein 200g
Lactose 771g
Methylcellulose 19g
Oleum menthae 9g
Magnesium stearate 1g
Take by weighing each composition by above-mentioned amount, lactein, lactose, methylcellulose are crossed mix homogeneously behind 80 mesh sieves respectively, make soft material with an amount of ethanol, 20 mesh sieves are granulated, 60 ℃ of oven dry, 20 order granulate, Oleum menthae and dried granule, magnesium stearate mixing, airtight 24 hours, tabletting got final product.
Embodiment 4: 1000 lactein chewable tablet of present embodiment preparation, use following component:
Lactein 300g
Sorbitol 655g
Gelling starch 30g
Rhizoma et radix valerianae oil 13g
Macrogol 4000 2g
Take by weighing each composition by above-mentioned amount, lactein, sorbitol, gelling starch are crossed mix homogeneously behind 80 mesh sieves respectively, make soft material with an amount of ethanol, 20 mesh sieves are granulated, 60 ℃ of oven dry, 20 order granulate, Rhizoma et radix valerianae oil and dried granule, Polyethylene Glycol mixing, airtight 24 hours, tabletting got final product.
Embodiment 5: 1000 lactein chewable tablet of present embodiment preparation, use following component:
Lactein 450g
Calcium carbonate 525g
Polyvinylpyrrolidone 10g
Strawberry essence 15g
Take by weighing each composition by above-mentioned amount, lactein, calcium carbonate, polyvinylpyrrolidone are crossed mix homogeneously behind 80 mesh sieves respectively, make soft material with an amount of ethanol, 20 mesh sieves are granulated, 60 ℃ of oven dry, 20 order granulate, vanilla and dried granule, lubricant mixing, airtight 24 hours, tabletting got final product.
Embodiment 6: 1000 lactein chewable tablet of present embodiment preparation, use following component:
Lactein 480g
Microcrystalline Cellulose 500g
Low-substituted hydroxypropyl cellulose 15g
Grape essence 4g
Zinc stearate 1g
Take by weighing each composition by above-mentioned amount, lactein, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose are crossed mix homogeneously behind 80 mesh sieves respectively, make soft material with an amount of ethanol, 20 mesh sieves are granulated, 60 ℃ of oven dry, 20 order granulate, grape essence and dried granule, zinc stearate mixing, airtight 24 hours, tabletting got final product.
Claims (8)
1, a kind of lactein chewable tablet is made by lactein and adjuvant, it is characterized in that adjuvant comprises filler, binding agent and correctives; The percentage by weight of each component is in this chewable tablet: lactein 5%～48%, filler 50%～92%, binding agent 0.5%～3%, correctives 0.1%～1.5%.
2, lactein chewable tablet according to claim 1 is characterized in that also containing 0.1%～2% lubricant.
3, lactein chewable tablet according to claim 1 is characterized in that described filler is one or more the mixing in sucrose, lactose, spray-dried lactose, pelletiod lactose, Lactis Anhydrous, glucose, mannitol, sorbitol, sucrose-dextrin mixture, sucrose-Nulomoline mixture, carbohydrate admixture, starch, modified starch, dextrin, maltodextrin, beta-schardinger dextrin-, calcium hydrogen phosphate two water things, calcium phosphate, calcium carbonate, microcrystalline Cellulose, the micropowder cellulose.
4, lactein chewable tablet according to claim 1 is characterized in that described binding agent is one or more the mixing in starch, gelling starch, maltose, sodium alginate, calcium ammonium alginate, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, methylcellulose, sodium carboxymethyl cellulose, ethyl cellulose, polyvinylpyrrolidone, the low-substituted hydroxypropyl cellulose.
5, lactein chewable tablet according to claim 1 is characterized in that described correctives is one or more mixing in Oleum menthae, wintergreen oil, Oleum Caryophylli, Oleum Anisi Stellati, Fructus Citri Limoniae oil, mandarin oil, menthol, strawberry essence, vanilla, grape essence, the Fructus Citri tangerinae essence.
6, lactein chewable tablet according to claim 2 is characterized in that described lubricant is one or more the mixing in magnesium stearate, calcium stearate, zinc stearate, Macrogol 4000, polyethylene glycol 6000, Stepanol MG, the adipic acid.
7, according to the preparation method of any one described a kind of lactein chewable tablet of claim 1～6, it is characterized in that with lactein, filler, binding agent sieve respectively the back mixing, system soft material, granulation, oven dry, granulate, correctives and dried granule, lubricant mixing, tabletting.
8, the preparation method of lactein chewable tablet according to claim 7, it is characterized in that lactein, filler, binding agent are crossed mix homogeneously behind 80 mesh sieves respectively, make soft material with an amount of ethanol, 20 mesh sieves are granulated, 60 ℃ of oven dry, 20 order granulate are with correctives and dried granule, lubricant mixing, airtight 24 hours, tabletting got final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100535474A CN1729999A (en) | 2004-08-04 | 2004-08-04 | Lactein chewing tablet and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100535474A CN1729999A (en) | 2004-08-04 | 2004-08-04 | Lactein chewing tablet and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1729999A true CN1729999A (en) | 2006-02-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100535474A Pending CN1729999A (en) | 2004-08-04 | 2004-08-04 | Lactein chewing tablet and its preparing process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1729999A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101190251B (en) * | 2006-11-30 | 2012-05-02 | 四川宇妥藏药药业有限责任公司 | Rhodiola rosea chewable tablets and preparation method and application thereof |
| CN104642746A (en) * | 2015-03-23 | 2015-05-27 | 四川高福记生物科技有限公司 | Preparation method of feeding lactic acid bacteria micro pills |
| CN106259891A (en) * | 2015-05-28 | 2017-01-04 | 上海旺旺食品集团有限公司 | A kind of probiotic bacteria buccal tablet and preparation method thereof |
| CN106343132A (en) * | 2016-08-30 | 2017-01-25 | 四川高福记生物科技有限公司 | Lactic acid bacteria tablet candy with blueberry flavor and preparing method thereof |
| CN106359807A (en) * | 2016-08-30 | 2017-02-01 | 四川高福记生物科技有限公司 | Hawthorn-fruit-flavor lactobacillus tablet candies and preparation method thereof |
| CN113133979A (en) * | 2020-01-20 | 2021-07-20 | 亚宝药业太原制药有限公司 | A lactobacillus tablet with improved taste |
-
2004
- 2004-08-04 CN CNA2004100535474A patent/CN1729999A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101190251B (en) * | 2006-11-30 | 2012-05-02 | 四川宇妥藏药药业有限责任公司 | Rhodiola rosea chewable tablets and preparation method and application thereof |
| CN104642746A (en) * | 2015-03-23 | 2015-05-27 | 四川高福记生物科技有限公司 | Preparation method of feeding lactic acid bacteria micro pills |
| CN106259891A (en) * | 2015-05-28 | 2017-01-04 | 上海旺旺食品集团有限公司 | A kind of probiotic bacteria buccal tablet and preparation method thereof |
| CN106343132A (en) * | 2016-08-30 | 2017-01-25 | 四川高福记生物科技有限公司 | Lactic acid bacteria tablet candy with blueberry flavor and preparing method thereof |
| CN106359807A (en) * | 2016-08-30 | 2017-02-01 | 四川高福记生物科技有限公司 | Hawthorn-fruit-flavor lactobacillus tablet candies and preparation method thereof |
| CN113133979A (en) * | 2020-01-20 | 2021-07-20 | 亚宝药业太原制药有限公司 | A lactobacillus tablet with improved taste |
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