CN1708285A - Rinse-off personal care compositions comprising anionic and/or nonionic perfume polymeric particles - Google Patents

Abstract

The invention provides rinse-off personal care compositions comprising a perfume polymeric particle, which is useful as a delivery system for a perfume raw material (''PRM''), methods for making such personal care compositions and methods of treating substrates, such as skin and/or hair with such personal care compositions. The polymer is preferably selected from anionic or nonionic polymers, wherein said polymer further comprises an anionic monomer and a nonionic monomer.

Description

The rinse-off personal care compositions that comprises anion and/or nonionic perfume polymeric particles

Invention field

The present invention relates to comprise the rinse-off personal care compositions of perfume polymeric particles, it can be used as the delivery system of perfume base (" PRM "). The invention still further relates to the method for this personal care composition of preparation and the method for nursing substrate such as skin and/or hair with this personal care composition.

Background of invention

With beneficial agent process multiple substrate for example the surface of skin usually be desired or favourable, this beneficial agent comprises for example spices, flavouring agent, pharmaceuticals and/or biocontrol agent, described biocontrol agent comprises biocide, pesticide, mould inhibitor etc. The purpose of this processing normally is deposited on enough beneficial agents the surface of substrate, so that can give substrate surface residue beneficial effect.

In many consumer goods, spices, especially perfume base, it is desired can discharging lentamente with the passing of time. The volatile perfume base of tool of " top is fragrant " and " middle perfume (or spice) " is the key factor that causes consumer's " pure and fresh impression " experience owing to be called as, thus people expect that this has more volatile top perfume (or spice) can be slowly, controllable mode discharges.

Because under regular situation, a top group of Buddhists going together on a pilgrimage is decomposed because of evaporation and/or in aqueous medium and is lost, therefore formulator has made great efforts by detection technique losing of top perfume and middle perfume (or spice) to be reduced to minimum, this technology can improve the fragrant and deposition of middle perfume (or spice) on substrate in top, even even in the presence of water and/or subsequently this substrate with after water and/or moisture contact.

Formulator not yet can successfully deposit to top perfume (or spice) in the substrate effectively. The effort that prior art has been done comprises that with spices especially perfume base aggregates into polymer beads. Other effort has been attempted spices is sucked polymer beads. The effort of these prior aries fails to propose a kind of polymer beads, and this particle optionally absorbs/adsorb the fragrant and middle perfume (or spice) in top, and especially the top is fragrant.

Therefore, a kind of rinse-off personal care compositions need to be arranged, said composition comprises perfume polymeric particles, and this particle optionally absorbs/adsorb the fragrant and middle perfume (or spice) in PRM top, and this can improve/increase the perfume base content that is deposited on substrate and/or discharges from substrate; Also need a kind of method for preparing this personal care composition, and PRM is pushed up perfume (or spice) be delivered to substrate, especially the method for skin and hair.

Summary of the invention

The present invention comprises the personal care composition that contains the fragrant and/or middle fragrant perfume polymeric particles in perfume base (PRM) top and the method by this personal care composition of preparation is provided and by providing that the PRM top is fragrant and/or middle perfume (or spice) is delivered to Person's skin and/or people's hair and/or the method for pet hair has satisfied above-mentioned needs by providing.

In one aspect of the invention, provide personal care composition, this personal care composition comprises:

A) a kind of perfume polymeric particles, this particle comprises:

I) contain anion and/or the non-ionic polymers of anion and/or non-ionic monomer; With

Ii) contain the spices of one or more perfume bases, the molecular weight of this perfume base less than about 200 and/or boiling point less than about 250 ℃ and/or ClogP less than about 3 and/or Ke Fazi (Kovats) exponential quantity less than about 1700; With

B) personal nursing auxiliary element;

Preferably, wherein when this perfume base links to each other with this polymer with the form of perfume polymeric particles, with when this perfume base does not link to each other with this polymer with the form of perfume polymeric particles, compare, more perfume base can deposit on the substrate and/or from substrate and discharge, and spices as described herein deposits and sends testing scheme I and survey.

In another aspect of the present invention, personal care composition is provided, said composition comprises anion and/or non-ionic polymers particle, this particle comprises anion and/or non-ionic polymers, this polymer comprises anion and/or non-ionic monomer, wherein this anion and/or non-ionic polymers show to have larger perfume base affinity, this perfume base is compared with other perfume base, molecular weight less than about 200 and/or boiling point less than about 250 ℃ and/or ClogP less than about 3 and/or the Kovats exponential quantity less than about 1700, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys; And provide the personal nursing auxiliary element.

In another aspect of the present invention, personal care composition is provided, said composition comprises anion or non-ionic polymers particle, this particle comprises anion or non-ionic polymers, this polymer comprises anion or non-ionic monomer, wherein this anion or non-ionic polymers show that having larger perfume base affinity compares greater than about 1700 perfume base with other DB-5 Kovats index value, the DB-5 Kovats index value that this perfume base has is less than about 1500, spices as described herein deposition and send testing scheme I and/or polymer beads affinity testing scheme II surveys, and the personal nursing auxiliary element is provided.

In another aspect of the present invention, personal care composition is provided, said composition comprises anion or non-ionic polymers particle, this particle comprises anion or non-ionic polymers, this polymer comprises anion or non-ionic monomer, wherein this anion or non-ionic polymers show that the perfume base affinity with larger at least 1.2x compares greater than about 1700 perfume base with other DB-5 Kovats index value, the DB-5 Kovats index value that this perfume base has is between about 1000 and 1500, spices as described herein deposition and send testing scheme I and/or polymer beads affinity testing scheme II surveys, and the personal nursing auxiliary element is provided.

In another aspect of the present invention, the method for preparing personal care composition of the present invention is provided, said composition shows to have on skin and/or hair in time and the aromaticity that strengthens. The method comprises mixes anion of the present invention or non-ionic polymers particle with the spices that comprises perfume base, this perfume base molecular weight less than about 200 and/or boiling point less than about 250 ℃ and/or ClogP less than about 3 and/or the Kovats index value less than about 1700. This blend step can occur in and add before personal nursing auxiliary element and/or the personal care formulations. Alternatively, in the presence of auxiliary element and/or personal care formulations, blend step can occur, and/or this blend step can occur in sequence, and this aggregated particles and perfume base can be present in auxiliary element and/or the personal care formulations before other composition thus.

In another aspect of this invention, provide the method for preparing personal care composition of the present invention, the method comprises perfume polymeric particles of the present invention is joined in the personal nursing helper component.

In another aspect of the present invention, Person's skin to the needs nursing is provided, and/or the hair of people's hair and/or pet the method for nursing, the method comprises with perfume polymeric particles of the present invention and/or personal care composition contact Person's skin and/or people's hair and/or the step of pet hair; And alternatively, rinse this personal care composition, thereby make Person's skin and/or people's hair and/or the hair of pet obtain nursing.

In another aspect of the present invention, provide the substrate with the inventive method nursing.

In another aspect of the present invention, personal care composition and personal nursing auxiliary element are provided, personal care composition of the present invention comprises two or more perfume polymeric particles, and wherein these two or more perfume polymeric particles comprise at least a different monomer. Pass through embodiment, if be not limited, can form polymer beads a kind of in the perfume polymeric particles can be anion or nonionic aggregated particles, and other polymer beads can be anion and/or nonionic and/or amphoteric ion polymer particle.

In another aspect of the present invention, personal care composition and personal nursing auxiliary element are provided, personal care composition of the present invention comprises two or more perfume polymeric particles and spices, and wherein these two or more polymer beads comprise at least a different monomer; And this spices comprises perfume base, this perfume base molecular weight less than about 200 and/or boiling point less than about 250 ℃ and/or ClogP less than about 3 and/or the Kovats index value less than about 1700. By embodiment, if be not limited, a kind of polymer beads can be anion or non-ionic polymers particle, and other polymer beads can be anion and/or nonionic and/or amphoteric ion polymer particle.

In another aspect of the present invention, personal care composition is provided, personal care composition of the present invention comprises perfume polymeric particles, polymer beads of the present invention and contains the spices of perfume base, this perfume base molecular weight less than about 200 and/or boiling point less than about 250 ℃ and/or ClogP less than about 3 and/or the Kovats index value less than about 1700.

Therefore, the invention provides the personal care composition that comprises perfume polymeric particles, the method for preparing personal care composition and with perfume polymeric particles and/or personal care composition nursing Person's skin and/or people's hair and/or the method for pet hair.

One embodiment of the invention relate to perfume polymeric particles, and this perfume polymeric particles comprises: polymer; With the spices that comprises perfume base, this perfume base has one or more following character: molecular weight is less than about 200; Boiling point is less than about 250 ℃; ClogP less than about 3 and the Kovats index value less than about 1700; Wherein the response factor of this perfume polymeric particles (RF) is at least about 1.6.

Another embodiment of the invention relates to perfume polymeric particles, this perfume polymeric particles comprises: polymer and spices, this spices comprises more than a kind of LKI perfume base, every kind of Kovats index value that has is about 1000 to about 1400, and this LKI perfume base can provide the first average response factor (ARF jointly_LKI); And more than a kind of HKI perfume base, every kind of Kovats index value that has is greater than about 1700, and this HKI perfume base provides the second average response factor (ARF jointly_HKI); Wherein this perfume polymeric particles shows the ARF that has_LKI/ARF _HKIRatio is at least about 1.2.

The invention still further relates to the composition and the preparation perfume polymeric particles and the method that contains their composition that comprise according to the perfume polymeric particles of above-described embodiment.

Except as otherwise noted, all percentage, umber and ratio are all in the gross weight of the present composition. The all wt of relevant ingredients listed is all based on the content of active material, and therefore except as otherwise noted, they do not comprise solvent or the accessory substance that may be included in the commercially available material.

Except as otherwise noted, all molecular weight used herein are weight coefficient molecular weight, with a g/mol expression.

Detailed Description Of The Invention

Definition:

" non-polymeric combination " used herein refers to that spices is attracted in the polymer after polymer forms, and/or is adsorbed on the polymer, and/or in other words combines with polymer. In other words, during this polymer carried out polymerisation and/or melting, this spices did not exist with this polymer. Described another kind of method is that this spices mixes with preformed polymer beads, to produce perfume polymeric particles of the present invention. For purposes of the invention, this definition does not comprise encapsulated, and wherein polymer encapsulates spices. Preferably, this polymer fragrance particle is not the preformed matrix system that is loaded with spices.

" independent add " used herein only refers to after this polymer or spices have mixed with one or more auxiliary elements that comprised shaping system matrix, and spices is attracted in the polymer and/or is adsorbed on the polymer and/or in other words combines with polymer. Described another kind of method is, in the presence of auxiliary element, this spices mixes with preformed polymer beads, or polymer beads mixes with spices in the presence of auxiliary element, with generation perfume polymeric particles in the presence of shaping system matrix. For purposes of the invention, this definition of independently adding does not comprise encapsulated, and wherein polymer encapsulates spices, although polymer beads of the present invention can comprise the encapsulated thing of the material that is suitable for encapsulating non-perfume base.

" auxiliary element " used herein refers to can be used for prepare those compositions of the method for beneficial agent polymerization delivery system. For example, this delivery system comprises personal nursing/cleaning products, hair articles for use etc. Auxiliary element is also referred to as the product formulation composition.

" benefit agent delivrery systems " used herein refers to comprise the product composition of beneficial agent, polymer beads and nonessential auxiliary element. At described substrate with after described benefit agent delivrery systems contacts, said composition put at any time with can improve or increase beneficial agent on substrate deposition and/or beneficial agent from the mode combination of the release of substrate. Benefit agent delivrery systems includes but are not limited to personal nursing/cleaning products.

" directly using " used herein, " directly using " or " directly sending " refer to by benefit agent delivrery systems beneficial agent is administered on the substrate, so that before dilution subsequently or when also not carrying out subsequently dilution, the beneficial effect that beneficial agent provides is implemented and/or approves. That is, the beneficial effect delivery system of this class can be used as the leave product configuration, and this leave product can be applied to substrate, and need not to be diluted or rinsing. For example, be sprayed at beneficial agent on the substrate and/or wiping on substrate, and be not from dilution (that is, wash liquid) contact substrate or indirectly be deposited on substrate with beneficial agent. Non-limiting example comprises using of first-class aromatic spices or aesthetic nursing product goods, as, white cream, distillate medicinal water, deodorant, antiperspirant and other topical composition; Hair care product, such as the hair spray, retain the formula conditioner, etc.

" indirectly using " used herein, " indirectly using " or " indirectly using " refer to that the dilution of this substrate and this benefit agent delivrery systems contacts, as, in the dispersion of the aqueous solution or this benefit agent delivrery systems, contact. For purposes of the invention, " dilute solution " of this delivery system is the solution that contained useful agent concentration is lower than beneficial agent concentration in the front delivery system of dilution, the contained useful agent concentration of this solution is at least about 10%, preferably at least about 30%, more preferably at least about 50%. This dilution or dispersion can form by dilute with water delivery system or the final products that comprise this delivery system. Non-limiting example is soap slab.

For purposes of the invention, the aqueous solution of delivery system or dispersion are systems that contains beneficial agent, the content of the beneficial agent of this system is no more than about 5000ppm, preferably be no more than about 500ppm, even more preferably no more than about 50ppm, and be most preferably not exceeding about 10ppm, even sometimes be no more than about 1ppm.

Spices

Spices comprises perfume base (" PRM "). Perfume base is characterised in that: their boiling point (B.P.) and/their Octanol/water Partition Coefficients (P), perhaps be called logP and when calculating, be considered to ClogP and/molecular weight and/or Kovats index value. The distribution coefficient of the octanol/water of this perfume base is this perfume base ratio between equilibrium concentration in octanol and in water. Because the distribution coefficient of fragrance component of the present invention has high numerical value, so they are more convenient for being presented take the form of the logarithm logP of they truth of a matter as 10. Therefore, the logP that has of fragrance component of the present invention is less than about 3. Personal care composition of the present invention preferably comprises one or more perfume bases of at least 0.1%.

The boiling point of many fragrance components provides in such as Steffen Arctander " Perfume and Flavor Chemicals (Aroma Chemicals) ", is published by the author in its 1969, and is incorporated herein by reference.

The logP of many fragrance components is reported, for example, and Pomona 92 databases, it contains many originals together with quoted passage, and this database is available from Daylight Chemical Information Systems, Inc. (Daylight CIS), Irvine, California. Yet the logP value can be calculated by " CLOGP " program the most easily, and this program is also available from Daylight CIS. But this program has also been listed the experiment value of logP time spent in Pomona 92 databases. Should " logP that calculates " (ClogP) be the determined (cf. of sheet phase method by Hansch and Leo, A.Leo, the 4th volume in Comprehensive Medicinal Chemistry, C.Hansch, P.G.Sammens, J.B.Taylor and C.A.Ramsden, Eds., the 295th page, Pergamon Press, 1990, be incorporated herein by reference). This segment method is based on the chemical constitution of each fragrance component, and will consider quantity and type, atom connectedness and the chemical bond of atom. In the selection to the fragrance component that is used for the present invention, this ClogP value is preferred the use, and is not to test the logP value, and this ClogP value is the most reliable and is widely used for estimating physicochemical properties.

Except the ClogP value, KI value (Kovats index value) also can be used for differentiating perfume base. This Kovats retention index system is a kind of accurately method, and with the report data from gas chromatography, the material that is used between the laboratory is differentiated. It is used for eliminating the impact about the instrument parameter of retention relationship in carry out the peak discriminating with gas-chromatography (GC). The Kovats index value of many fragrance components is reported, perhaps can be calculated by following formula.

Wherein n is the carbon number in less alkene; N is the carbon number in larger alkene; T '_r(n) be the adjustment retention time of less alkene; And t '_r(N) be the adjustment retention time of larger alkene. It should be noted that this formula is used for the concrete fixedly phase of GC post. Based on above-mentioned formula, the Kovats index value of linear paraffin equals 100 times of carbon number. For example, the KI value of octane is 800, and the KI value of decane is 1000. In another embodiment, go up mutually special, the KI value that octanol has is 826, and the KI value of hexadecanol is 1626. KI value used herein can be measured as the nonpolar stable phase in the post (being called as " DB-5 post ") by using dimethyl silicone polymer.

This definition makes the Kovats index value (KI) of linear paraffin or (RI) equals 100 times of carbon number. Octane I=800, and decane I=1000. Octanol is for example gone up mutually special, can be 826, and can be extrapolated to hexadecanol, and its KI is 1626.

The spices relevant with polymer beads of the present invention comprises perfume base (PRM), the molecular weight of this perfume base less than about 200 and/or boiling point less than about 250 ℃ (under the pressure of normal, standard, measuring) and/or ClogP less than about 3, and/or the Kovats index value is less than about 1700. This PRM usually is called " top is fragrant ".

Employed flavor compositions preferably comprises and middle perfume (or spice) fragrant at least about the top of 25% weight in the present invention, more preferably or middle perfume (or spice) fragrant at least about the top of 50% weight, even the more preferably fragrant or middle perfume (or spice) in top of at least 75% weight, wherein fragrant the and middle perfume (or spice) in top is exponential quantity less than those PRM of about 1700.

Employed flavor compositions more preferably comprises fragrant at least about the top of 25% weight by weight in the present invention, more preferably fragrant at least about the top of 50% weight, even more preferably the top of at least 75% weight is fragrant, and wherein top perfume is to have the Kovats index value less than those PRM of about 1400.

Have molecular weight less than about 200 and/or boiling point comprise less than the non-limiting example of about 3 suitable PRM less than about 250 ℃ and/or ClogP, but be not limited to jasmone, linalool, nerol, benzyl carbinol, α-terpineol, eugenol, indoles, meat methyl silicate, methyl N methyl anthranilate, vanillic aldehyde, isobornyl acetate, carvacrol, α-citronellol, citronellol, anisaldehyde, linalyl acetate, artificial neroli oil, acetic acid bacteria ester and the dihydromyrcenol of benzaldehyde, benzyl acetate, left-handed carvol, geraniol, laurine, cis.

In one embodiment, molecular weight less than about 200 and/or boiling point be selected from less than about 3 PRM less than about 250 ℃ and/or ClogP: jasmone, linalool, nerol, benzyl carbinol, α-terpineol, dihydromyrcenol, citronellol, anisaldehyde, linalyl acetate, artificial neroli oil, acetic acid bacteria ester and their mixture of benzaldehyde, benzyl acetate, left-handed carvol, geraniol, laurine, cis.

The PRM that is applicable to personal care composition of the present invention in addition can be differentiated in the described KI table below.

Representational PRM is differentiated in KI table described herein.

Extremely low KI (VLKI)
				PRM	The KI value	CAS#	Molecular weight
Ethyl acetate	604	141-78-6	88.1
				The 2 Methylpropionic acid methyl esters	685	547-63-7	102.1
The 3-hydroxy-2-butanone	718	513-86-0	88.1
				The 1-hexene-3-ol	789	4798-44-1	100.1

Propyl propionate	812	106-36-5	116.1
				Ethyl 2-methylbutyrate	849	7452-79-1	130.1
(Z)-blatter alcohol	858	928-96-1	100.1
				Propyl butyrate	898	105-66-8	130.1
Australene	937	80-56-8	136.1
				Low KI (LKI)
Nopinene	1002	127-91-3	136.1
				Limonene	1033	138-86-3	136.1
Benzylalcohol	1037	100-51-6	108.1
				Melonal	1055	106-72-9	140.1
Dihydromyrcenol	1072	18479-58-8	156.2
				Methyl benzoate	1081	93-58-3	136.1
Linalool	1100	78-70-6	154.1
				Ligustral	1090，1119	68039-49-6	138.1
Methyl cinnamate	1113	103-26-4	162.1
				Benzyl carbinol	1122	60-12-8	122.1
Citronellal	1155	106-23-0	154.1
				Benzyl acetate	1164	140-11-4	150.1
The 1-carvol	1227	6485-40-1	150.1
				Citronellol	1237	106-22-9	156.2
Citral	1254	5392-40-5	152.1
				Anisaldehyde	1271	123-11-5	136.2
Geraniol	1275	106-24-1	154.1
				Ethyl benzoate	1300	93-89-0	150.1
Artificial neroli oil	1359	134-20-3	151.2
				Eugenol	1364	97-53-0	164.1
Beta-damascenone	1386	23726-93-4	190.1
				δ-damascone	1394	71048-82-3	192.2

Middle KI (MKI)
				PRM	The KI value	CAS#	Molecular weight
				Vanillic aldehyde	1410	121-33-5	152.0
α-ionone	1425	127-41-3	192.2
				The acetic acid bacteria ester	1443	2500-83-6	192
γ-irisone	1445	79-76-5	192.2
				Geranyl propionate	1476	105-91-9	210.2
Alpha, beta-lonone	1493	14901-07-6	192.2
				Santal	1512	065113-99-7	210.2
Geranyl acetate	1577	105-87-3	196.1
				Helional	1589	1205-17-0	192.1
				High KI (HKI)
PRM	The KI value	CAS#	Molecular weight
				(E)-methyl cinnamate	1700	1754-62-7	162.1
Ambrotone	1703	54464-57-2	234.2
				1-Hexyl salicylate	1713	6259-76-3	222.1
δ-dodecalactone	1713	713-95-1	198.2
				N-nonanoic acid	1762	112-05-0	158.1
Jasminolene	1770	101-86-0	216.2
				Ergol	1791	120-51-4	212.1
Cedryl acetate	1811	77-54-3	264.2
				Ambrox	1812	100679-85-4	236.2
Pentadacanolide	1876	106-02-5	240.2
				Phenylethyl benzoate	1887	94-47-3	226.2
Galaxolide	1893	1222-05-5	258.2
				4-cyclopentadecylene-1-ketone	1901	14595-54-1	222.2
Isoeugenol	1902	97-54-1	164.1

Benzyl salicylate	1904	118-58-1	228.1
				Acetic acid phenethyl phenylester	1945	102-20-5	240.1
Moschus C14/Zenolide	1959	54982-83-1	256.2
				Geranyl benzoate	1985	100012-96-0	258.2
Phenylethyl salicylate	1987	87-22-9	242.1
				(E, E)-fanesol	2002	106-28-5	222.2
The tridecanoic acid vinyl acetate	2060	105-95-3	270.2
				Tetradecanol	2116	4706-81-4	214.2
Phytol	2128	7541-49-3	296.5
				Acetovanillone	2292	498-02-2	166.1

Concerning the present invention and testing scheme described herein, the PRM of low KI (" top is fragrant ") refers to that the Kovats index value is less than about 1400 PRM, and the PRM of high KI (" bottom note ") refers to the Kovats index value greater than about 1700 PRM, and middle KI PRM (" middle perfume (or spice) ") refers to the PRM of Kovats index value between about 1400 and about 1700.

Scheme I spices deposits and sends test

The perfume polymeric particles that is used for flavor compositions of the present invention comprises perfume polymeric particles, and this particle can improve or increase and deposits on the substrate and/or by the content of the perfume base of substrate release.

For measure perfume polymeric particles whether can improve or be increased on the substrate deposition and/or from the release of substrate, following testing scheme is provided. For these testing schemes, with the textile article in aqueous medium as substrate. This spices deposition and send test and can be used to test perfume polymeric particles and whether belong to scope of the present invention. When all following testing schemes so showed, the spices polymer did not then belong to the scope of the invention.

Scheme IA (perfume base is sent or life test I)：

According to scheme IA, test each benefit agent delivrery systems, this system comprises perfume base and polymer beads. Usually the every kind of perfume base (PRM) and the every kind of polymer beads (PP) that are present in the spices are jointly tested, whether represent raising and/or the increase of the PRM content sent to measure this combination (PRM-PP), and/or the life-span only is longer than the separately life-span of PRM gained.

As long as this combination does not affect this analysis measurement method (such as, chromatography), can simultaneously in the presence of one or more polymer beads (PPs), test together multiple PRM.

For example, contain three kinds of PRM and a kind of polymer beads (PP¹) the PRM delivery system need following monotropic test: with this sample and tester comparison, this sample contains PRM¹-PP ¹， PRM ²-PP ¹And PRM³-PP ¹, this tester contains PRM¹，PRM ²And PRM³, precondition is that described PRM can separate by chromatographer, so can in the presence of another kind of PRM, measure the amount of every kind of PRM. Can not in discrete testing, must flow by chromatographer perfume base separated from one another.

In another embodiment, PRM wherein¹And PRM³Inseparable, so in the following test is essential:

I. sample (PRM¹-PP ¹And PRM²-PP ¹) and according to thing (PRM¹And PRM²) contrast, and sample (PRM³-PP ¹) and tester (PRM³) contrast; Or

II. sample (PRM²-PP ¹And PRM³-PP ¹) and tester (PRM²And PRM³) contrast, and sample (PRM¹-PP ¹) and tester (PRM¹) contrast, or

III. sample (PRM¹-PP ¹) and tester (PRM¹) contrast, sample (PRM²- PP ¹) and tester (PRM²) contrast, and sample (PRM³-PP ¹) and tester (PRM³) contrast.

PRM in any test should not exist with the concentration that is far longer than another kind of PRM in the same test so that the result is affected (that is, can make the result significantly be different from the result during by independent test as PRM). Typically, when the concentration of PRM does not exceed 10 times, in same test, this result does not show the impact that existed by other PRM. Being affected if test result shows, is essential to the discrete testing of PRM then.

(a) concentration of specimens

In a series of solution based on TS0, being used to the PRM of life test (LT) and the concentration of PP is least concentration, wherein in test solution, every kind of PRM is detected in the head space sample, and this sample is to collect from the substrate of processing at the time point of one or more appointments. If this condition does not satisfy TS₀, then in test solution, PRM and PP concentration are doubled, and test in the same manner new solution (TS₁). The method is repeated, until satisfy above-mentioned PRM testing conditions. Satisfying the test solution (TS of above-mentioned PRM testing conditions_n) in, the concentration of PRM and PP and TS₀The concentration of middle PRM and PP is relevant, and it is according to following formula:

[PRM, PP] is (at TS_nIn)=2ⁿ[PRM, PP] is (at TS₀In); N=0 wherein, 1,2,3...

In certain embodiments, the method that concentration is doubled can be repeated, and all surpass 5% until the concentration of PRM and PP is pressed the weighing scale of described test solution, and this above-mentioned PRM testing conditions satisfies yet. So following selective method can be used for carrying out this test. Be transferred to the TS on the substrate_nAliquot is increased to 3mL by 1.0mL, subsequently to 10mL, until (i) satisfy above-mentioned PRM testing conditions, or (ii) for the PRM of individual concentrations greater than 0.1% weight of spices, satisfy at least a kind of in following two kinds of alternative conditions:

(1) in test solution, the PRM of at least 80% low KI, and in test solution, the PRM of at least 80% high KI is detected in the head space sample, this sample is to collect from the substrate of processing at the time point of one or more appointments; Perhaps

(2) in test solution, the PRM of at least 10 kinds of low KI, and in test solution, the PRM of at least 5 kinds of high KI is detected in the head space sample, this sample is to collect from the substrate of processing at the time point of one or more appointments.

B) test program

Dissolve in or sneak into composition by the PRM that will be tested together and PP and prepare test solution, said composition equals for those of the consumer goods in concentration. For example, PRM and the PP concentration in the consumer goods can be respectively 2.0% and 4.0%. This solution at room temperature by secluding air and by ageing 24 hours, to obtain initial test solution, is appointed as TS₀。

One heavy 0.45 to 0.65g, and the circular fabric of diameter 4cm can be divided into 86/14 cotton/crinosity circle bath towel. (available from EMC, 7616 Reinfold Drive, Cincinnati, OH 45237) and be used as testing substrate. In given test, substrate weight difference each other should be within ± 0.02g. With the sensing of pipette close to the substrate center, with pipette with TS₀A 1.0mL aliquot be transferred on this substrate. Then, the 1.0mL aliquot with deionization (DI) water adds to substrate with the same manner. By this substrate being spumed in 1 minute with the palm friction that wears the nitrile gloves. This substrate then is put in the bottle, and this bottle contains 40mL, 35 ℃ DI water; This bottle is added a cover and shake 30 seconds.

Then by the use tweezers this substrate is moved, and blot to remove excessive water at paper handkerchief lightly. To by the substrate of above-mentioned steps (comprise with test solution and inject, dilute, foam/washing and rinse) processing, under environmental condition, be exposed to the time period of appointment in the air with air-dry. Subsequently, (HSGC) analyzes this substrate by headspace gas chromatography, with the amount of every kind of perfume base in the head space that is determined at following each time: 2,6 and 24 hours. Analyze spices with gas chromatography-mass spectrum (GC-MS).

C) headspace gas chromatography (HSGC)

Suitable unit describe is in the J. of S.Maeno and P.A.Rodriguez Chromatography, and A731 rolls up (1996), the 201st to 215 page. This device comprises:

1) headspace enrichment device, it comprises this substrate (dry such as above-mentioned processing and air) and allows PRM to be dispensed into headroom and reach balance;

2) contain poromeric grabber, it has the ability that keeps aromatic substance;

3) transfer device, its with the headroom vapor transfer of catching to GC for quantitative analysis; With

4) GC-MS, it has the headroom detectability, and with helium as mobile phase.

As mentioned above, processed and air drying the substrate of fixed time section be put in the headspace enrichment device and allow to distribute and reach balance, it needs about two hours. After balance, have the aromatic substance ability of reservation and contain poromeric grabber operationally is connected to catch balance with the headspace enrichment device headroom steam, the preferred Tenax of this grabber^TA 35/60 order (available from Gerstel, Inc., Baltimore, MD). Transfer device be used for the head space vapor transfer that will catch to GC for quantitative analysis, this steam comprises the spices material. This device can heat this porous polymer grabber that comprises collected head space steam, and can with vapor transfer extremely, be cooled to the cooling grabber (usually using cooled with liquid nitrogen) that is lower than-100 ℃ of pacts. After being transferred to this cooling grabber fully, should cool off grabber in the short time, typically, quickly heat up to about 280 ℃ temperature in about 1 minute, cause the head space steam directly to be transferred to the Capillary GC post.

Typical pillar is that 30-60 rice is long and have the internal diameter of 0.18-0.32mm, and has fixing phase (for example, 100% dimethyl polysiloxane or contain the phenyl methyl polysiloxanes of 5% phenyl of having an appointment). This GC-MS can Identification and determination aldehydes or ketone PRM. Realize differentiating by mass spectral analysis, and by using individual detectors to carry out quantitatively, such as FID (flame ionization) detector or PID (photoionization) detector. Concrete GC/MS condition is described below.

On DB-5 post (dimethyl siloxane, 60m * 0.32mm, 0.25 μ m), with MS (for the identification of) and the separate mode of FID (be used for quantitatively), this perfume composition is separated. The GC condition is as follows: this sample kept 2 minutes under about 35 ℃ furnace temperature, and the speed that then this GC is set as with 4 ℃/minute is warming up to 200 ℃, was warming up to 325 ℃ with 10 ℃/minute speed subsequently. Inlet pressure is held constant at 13.7psi (9.45 N/m²), it is suitable with about 2.4mL/ minute inert gas (such as, helium) flow velocity. The MS condition is as follows: sweep limits is 35 to 400amu (atomic units). Transfer-line temperature is maintained at about 250 ℃.

This quantitative measurment should be can repeat in 20% scope of flow process mean value. If from the result that draws to flow process not in described scope, then should abandon from the data of described flow process gained and retest. Can report the mean value of at least 3 satisfied flow processs.

D) example results

Prepare the test solution TS of an appointment_n, it satisfies above-mentioned PRM testing conditions or alternative condition. Prepare second test solution TS_c, its with at TS_nIn identical concentration contain all TS_nComposition, just do not comprise this polymer beads. By using a kind of solution (TS_c) carry out identical program, this solution does not comprise polymer beads (PPs). This solution TS_cCan be used as the contrast solution in the test. Under same test condition, collect the above-mentioned test solution (TS of one group of appointment_cAnd TS_n) data, and analyze this data by headspace gas chromatography (HSGC), be determined at the amount of every kind of PRM in the head space with in following three fixed times each: 2,6 and 24 hours. Following table has proved that this class can be available from the result of life test I.

Life test (time=24 hour)

Contain and do not contain the HSGC reference area of the PRM with low KI* (LKI) value of PP1.
						PRM 1		PRM 2		PRM 3
TS c	TS n	TS c	TS n	TS c	TS n
						38,000	418,000	250,000	250,000	55,000	275,000
RF＝11x		RF＝1.0x		RF＝4.1x
						ARF LKIValue=average response factor values (TSn/TS c)＝5.4

Contain and do not contain the HSGC reference area of the PRM of the high KI* of having of PP1 (HKI) value.
						PRM 4		PRM 5		PRM 6
TS c	TS n	TS c	TS n	TS c	TS n
						110,000	143,000	10,000	12,000	550,000	550,000
RF＝1.3x		RF＝1.2x		RF＝1.0x
						ARF HKIValue=average response factor values (TSn/TS c)＝1.2

Wherein RF refers to response factor, and it is point at the appointed time, in head space from TS_nThe amount of the beneficial agent of sample collection (for example, perfume base) and is put in head space from TS at one time_cThe ratio of the amount of the identical beneficial agent of collecting; The ARF value is the average response factor values, and it is the mean value of the RF of all tested PRM gained from test solution.

The making of perfume polymeric particles increases that long-life beneficial effect is proved to be because concrete PRM, when in any one of three fixed times point, the RF of concrete PRM is at least about 1.2, preferably at least about 1.6, more preferably at least about 2, even more preferably at least about 3, still more preferably at least about 5, and even still more preferably at least about 10. Increase long-life beneficial effect if can determine to make, this perfume polymeric particles then is within the scope of the present invention so.

For example, the data acknowledgement in the upper table PRM¹And PRM³At PP¹Growth life-span beneficial effect under existing is because equal 24 hours drying time at air, by TSⁿThe PRM/PP that calculates is than TS_cDemonstration have larger HSGC area.

In addition, if confirm the growth life-span beneficial effect of PRM mixture, then perfume polymeric particles belongs to scope of the present invention. This of proof PRM mixture increases life-span beneficial effect, and when in any one of three fixed times points, this RF or ARF satisfy one or more following requirements:

1. during response factor that the response factor of observing when one or more LKI (top fragrant) perfume base is observed greater than any HKI perfume base; Or

2. during the average response factor that the response factor of observing when one or more LKI perfume bases is observed greater than the HKI perfume base; Or

3. during ARF that the average response factor (ARF) of observing when all tested low Kovats index value (LKI) perfume bases (PRM) is observed greater than all tested high Kovats index value (HKI) perfume bases (PRM).

For example, the data acknowledgement in upper table the PRM mixture (contain PRM^1-6And PP¹) the growth life-span beneficial effect of perfume polymeric particles.

4. during ARF that the average response factor (ARF) of observing as all tested LKI PRM is observed greater than all tested HKI PRM, the ARF that LKI PRM observes is at least about 1.2, be preferably at least about 1.6, more preferably at least about 2, even more preferably at least about 3, also more preferably at least about 5, and even still more preferably at least about 10. Specifically, ARF_LKIValue/ARF_HKIThe ratio of value is also referred to as the optional ratio, and it is at least about 1.2, is preferably at least about 1.6, is preferably at least about 2, more preferably at least about 3, even more preferably at least about 5, still even more preferably at least about 10. In addition, and if not bound by theory, this optional ratio proves that also low KI PRM has better selective or affinity than the polymer beads of high KI PRM.

Scheme IB (perfume delivery or life test II)：

According to scheme IB, test each benefit agent delivrery systems, this system comprises polymer beads, wherein perfume base by with the consistent test of each polymer beads (PP), whether prove that with the combination of measuring PRM and PP sending the meeting that the PRM content that discharges in substrate or from substrate or sustained release time obtains with respect to independent PRM increases or improve.

In scheme IB, at above-mentioned TS_nAnd TS_cIn the perfume polymeric particles of life test, with following variation, should assess out all 20 kinds of PRM (comprise 10 kinds of Kovats index values in 1000 and 1400 PRM and 10 kinds of Kovats index values greater than 1700 PRM, all PRM are selected from PRM representative in upper table).

In 20 kinds of PRM mixtures, the relative concentration that is used for each PRM of biometrics is such, under this concentration, at the appointed time putting by HSGC at least one (2,6 or 24 hours) point, can detect among 20 kinds of PRM in the test fluid at least 18 kinds. If TS₀Do not satisfy this condition, then the PRM total concentration in the test fluid is doubled, and tests in an identical manner this new solution (TS₁). Can repeat the method, until meet this condition, precondition is that the PRM total concentration in the test fluid is no more than 5%. If at least one point, by HSGC, in 20 kinds of PRM of TS, what can detect is less than 18 kinds at the appointed time, then should adjust by improving the PRM concentration that is not detected by HSGC the relative concentration of these 20 kinds of PRM. If this condition does not still satisfy evaluated benefit agent delivrery systems, the PRM that this should be detected is replaced by alternative PRM, and it is selected from representative PRM in the above-mentioned table of this paper.

In addition, if any TS among 20 kinds of PRM_nThe HSGC reference area, less than TS_cThe HSGC reference area, the response factor value of this PRM is decided to be 1.0x.

In addition, if TS_cIn the HSGC reference area of low Kovats index value PRM be zero, for example, its HSGC reference area is lower than the detection lower limit of instrument and TS_nIn the HSGC reference area of same low Kovats index value PRM non-vanishing, then as mentioned above, prepare new test solution, to improve PRM at TS_nAnd TS_cIn content, thereby obtain the nonzero value of HSGC reference area. If these steps do not provide TS_cThe nonzero value of middle PRM is decided to be 10x with the response factor value of this PRM.

Similarly, if TS_nIn the HSGC reference area of high Kovats index value PRM be zero, for example, its HSGC reference area is lower than the detection lower limit of instrument, and if TS_cIn the HSGC reference area of high Kovats index value PRM non-vanishing, then as mentioned above, carry out each step to improve PRM at TS_nAnd TS_cIn content, to obtain nonzero value. If these steps do not provide TS_nThe nonzero value of middle PRM is then replaced this PRM with alternative PRM in the table, to obtain at TS_nAnd TS_cMiddle response factor value is nonnegative value.

Following table has proved that this class can be available from the result of life test II.

Life test (time=24 hour)

Contain and do not contain the HSGC reference area of the PRM with low KI value of PP1.
						PRM 1		PRM 2		PRM 3
TS c	TS n	TS c	TS n	TS c	TS n
						ND	418,000	250,000	250,000	55,000	275,000
RF＝TS n/TS c＝10x		RF＝TS n/TS c＝1.0x		RF＝TS n/TS c＝4.1x
						ARF LKIValue=average response factor values (TSn/TS c)＝5.0

ND=does not detect.

During ARF that the ARF that observes as 10 kinds low Kovats index values (LKI) PRM observes greater than 10 kinds high Kovats index values (HKI) PRM, polymer beads belongs to the scope of the invention. Particularly, ARF_LKIValue/ARF_HKIThe ratio of value is also referred to as the optional ratio, and it is at least about 1.2, is preferably at least about 1.6, be preferably at least about 2, and more preferably at least about 3, even more preferably at least about 5, and even more preferably at least about 10. In addition, this optional ratio proves that also low KI PRM has better selective or affinity than the polymer beads of high KI PRM.

The test of polymer beads affinity:

The polymer beads that is used for personal care composition of the present invention comprises anion or non-ionic polymers particle, this particle comprises anion or non-ionic polymers, its perfume base shows to have the affinity larger than other perfume base, this perfume base molecular weight less than about 200 and/or boiling point less than about 250 ℃ and/or ClogP less than about 3 and/or the Kovats index value less than about 1700. Whether be within the scope of the present invention for measuring anion or non-ionic polymers particle, following polymer beads affinity testing scheme II is provided.

Polymer beads affinity testing scheme II

Fully mix the aqueous dispersion of this polymer beads with perfumery oil, and then (40,000rpm) ultracentrifugation was separated with 4,189rad/s with this system in 16 hours. After centrifugal, in this centrifuge separating substances be distinguishable which floor, for example, perfumery oil (upper strata), water-bearing layer (middle level) and stratum granulosum (bottom). Every one deck sample can be by suitable organic solvent (such as, acetone) extraction, and can analyze by GC/MS, to identify spices by the instrument condition of appointment above using. Show that the perfume base that contains of verifying of the polymer particles with character of the present invention demonstrates selectively in stratum granulosum, this perfume base molecular weight less than about 200 and/or boiling point less than about 250 ℃ and/or ClogP less than about 3 and/or the Kovats index value less than about 1700.

Anion or non-ionic polymers particle (PP)

This anion or non-ionic polymers particle are by at least one anion or non-ionic monomer, and choose any one kind of them or multiple cationic monomer, also preferred cross-linking monomer and polymerization. This polymerization can be any suitable method known in the art, for example, and emulsion and/or suspension and/or mini-emulsion polymerization. Between polymerization period, emulsifying agent and/or stabilizing agent can exist, in case polymer beads condenses and/or from the aqueous solution that forms polymer beads free out.

If perfume polymeric particles has following defined non-zero zeta potential, then they are defined as charged particle (anion or cation). Zeta potential is measured by Brookhaven Zeta Plus Zata (ζ) potentiometric analyzer. At first prepare the diluted suspension of perfume polymeric particles (namely, contain the 0.1g particle in 25g deionization (DI) water, if or it can add 1 perfume polymeric particles when being provided as solution), then 1 to 2 this suspension is diluted in the 10mM KCl solution. Do not adjust the pH value of system. The sample that dilutes in KCl solution is carried out the zeta potential analysis. For purposes of the invention, if the average result of 10 tests thinks that then this particle is anion, if average is positive zeta potential then thinks cation for negative zeta potential. Monomer that can the selective polymerization composition granule is so that the anion of gained and non-ionic polymers particle have perfume base affinity, this perfume base has and is lower than about 200 molecular weight, be lower than about 250 ℃ boiling point, be lower than about 3 ClogP value and/or be lower than about 1700 Kovats index value.

In another embodiment, monomer that can the selective polymerization composition granule, so that showing, the anion of gained or non-ionic polymers particle have the perfume base affinity larger than other perfume base, the DB-5 Kovats index value of this perfume base is between about 800 and 1500, the DB-5 Kovats index value of other perfume base is greater than about 1700, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that showing, the anion of gained or non-ionic polymers particle have the perfume base affinity larger than other perfume base, the DB-5 Kovats index value of this perfume base is between about 1000 and 1500, the DB-5 Kovats index value of other perfume base is greater than about 1700, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 1.2x perfume base affinity, this ratio is at least four kinds of DB-5 Kovats index values in the perfume base affinity between about 1000 and 1400 and at least four kinds of DB-5 Kovats index values greater than the optional ratio between about 1600 the perfume base affinity, spices deposition as described herein and send testing scheme I and survey.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 1.2x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1500 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 1.2x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1400 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, described spices deposition as described herein and send testing scheme I and/or II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 1.6x perfume base affinity, this ratio is the perfume base affinity of at least four kinds of DB-5 Kovats index values between about 1000 and 1400, and at least four kinds of DB-5 Kovats index values are greater than the optional ratio between about 1600 the perfume base affinity, and spices as described herein deposits and sends testing scheme I and survey.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 1.6x perfume base affinity, this ratio is DB-5 Kovats index in the perfume base affinity between about 1000 and 1500 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 1.6x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1400 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, described spices deposition as described herein and send testing scheme I and/or II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 2x perfume base affinity, this ratio is DB-5 Kovats index in the perfume base affinity between about 1000 and 1400 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 2x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1500 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 2x perfume base affinity, this ratio is the perfume base affinity of at least four kinds of DB-5 Kovats index values between about 1000 and 1400, and at least four kinds of DB-5 Kovats index values are greater than the optional ratio between about 1600 the perfume base affinity, and spices as described herein deposits and sends testing scheme I and survey.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 3x perfume base affinity, this ratio is the perfume base affinity of at least four kinds of DB-5 Kovats index values between about 1000 and 1400, and at least four kinds of DB-5 Kovats index values are greater than the optional ratio between about 1600 the perfume base affinity, and spices as described herein deposits and sends testing scheme I and survey.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 3x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1500 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 3x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1400 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 5x perfume base affinity, this ratio is the perfume base affinity of at least four kinds of DB-5 Kovats index values between about 1000 and 1400, and at least four kinds of DB-5 Kovats index values are greater than the optional ratio between about 1600 the perfume base affinity, and spices as described herein deposits and sends testing scheme I and survey.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 5x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1500 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 5x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1400 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 10x perfume base affinity, this ratio is the perfume base affinity of at least four kinds of DB-5 Kovats index values between about 1000 and 1400, and at least four kinds of DB-5 Kovats index values are greater than the optional ratio between about 1600 the perfume base affinity, and spices as described herein deposits and sends testing scheme I and survey.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 10x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1400 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or II surveys.

In another embodiment, monomer that can the selective polymerization composition granule, so that the anion of gained or non-ionic polymers particle show the optional ratio with 10x perfume base affinity, this ratio is DB-5 Kovats index value in the perfume base affinity between about 1000 and 1500 and other DB-5 Kovats index value greater than the optional ratio between about 1700 the perfume base affinity, spices deposition as described herein and send testing scheme I and/or polymer beads affinity testing scheme II surveys.

This polymer beads can be derived from about 50% to about 99.9% and/or about 60% to about 95% non-cationic monomer by weight, about 0.1% to about 50% and/or about 1% to about 10% cationic monomer by weight not necessarily, and about 0% to about 25% and/or about 1% to about 10% cross-linking monomer by weight.

Can about 10: 0: 0 to about 5: 1: 1 non-cationic monomer: cationic monomer: the cross-linking monomer weight ratio is used and is aggregated the monomer that forms polymer beads.

In one embodiment, this polymer beads has about 100nm to the average grain diameter of about 39 μ m.

In another embodiment, this polymer beads can have about 3 μ m to about 39 μ m and/or about 5 μ m to about 20 μ m and/or about 5 μ m to the average grain diameter of about 12 μ m.

In another embodiment, this polymer beads can have about 100nm to about 1 μ m and/or about 200nm to about 900nm and/or about 700nm average grain diameter of about 900nm extremely.

In one embodiment, the glass transition temperature that this polymer beads has (Tg) is about 50 ℃ to about 150 ℃, preferred about 80 ℃ to about 120 ℃.

In one embodiment, behind monomer polymerization, this polymer beads can comprise a kind of single polymer. During this monomer polymerization, this emulsifying agent and/or stabilizing agent can be grafted in the polymer beads of gained.

In another embodiment, this aggregated particles can comprise two or more polymer. For example, this polymer beads can comprise the first polymer that derives from monomer polymerization, and second polymer relevant with the first polymer, for example, and emulsifying agent and/or stabilizing agent (that is, polyvinyl alcohol (PVA)). When aggregated particles comprised two or more polymer, the concentration of every kind of polymer was preferably by described personal care composition weighing scale at least about 0.01%, more preferably at least about 0.1%, even more preferably at least about 0.25%.

What expect is that this polymer beads is stable in aqueous dispersion. The net charge of the average grain diameter of resulting polymers particle and/or resulting polymers particle can affect the stability of this polymer beads.

In one embodiment, the clean anionic charge that this polymer beads has is preferably pact-10mV to pact-80mV and/or pact-30mV pact-60mV and/or pact-35mV pact-55mV extremely extremely, is surveyed by Brookhaven zeta potential analyzer.

In addition, expectation be this polymer beads in product formulation, such as personal care composition, be stable in especially clean body and the Haircare composition.

In order to help to be stabilized in aqueous dispersion and/or product formulation, as, the polymer beads in the personal care composition can also be known as colloidal stabiliser with stabilizing agent, adds aqueous dispersion and/or product formulation. What expect is that this colloidal stabiliser can be compatible with other composition in aqueous dispersion and/or product formulation.

This polymer beads can be water-insoluble. In other words, in the time of in being added into water, within 5 minutes after the adding, this polymer beads physically with moisture from (that is, sedimentation, flocculation, float), yet, in 5 minutes after adding, " water-soluble " material physically not with moisture from. For purposes of the invention, the another kind of method of describing water-insoluble materials is that water-insoluble materials can not be dissolved in following concentration in distillation (or suitable) water under 25 ℃: (weight basis that adds polymer beads by water is calculated) is greater than about 5% and/or greater than about 3% and/or greater than about 1% by weight.

The molecular weight that this polymer beads can have is that about 0.0017 (1,000) is to about 3.32 (2,000,000), preferred about 0.008 (5,000) are to about 1.66 (1,000,000), more preferably from about 0.017 (10,000) to about 1.24 (750,000), more preferably from about 0.033 (20,000) are to 0.83ag (500,000 dalton). Can be by conventional gel permeation chromatography or any other molecular weight suitable, method mensuration polymer beads known to persons of ordinary skill in the art.

In one embodiment, this perfume polymeric particles comprises spices, this spices comprises perfume base greater than 50% by described spices weighing scale, and the molecular weight of this perfume base is less than about 200, boiling point less than about 250 ℃ and ClogP less than about 3 and/or the Kovats index value less than about 1700.

Even polymer beads of the present invention is anion or non-ionic polymers particle, can with having the monomer of cationic charge and/or both sexes electric charge, be used to form anion or non-ionic polymers particle with anion or non-ionic monomer.

The non-limiting example of suitable anionic polymerisation composition granule is commercially available by Rohm Haas take Allianz OPT as trade name.

Another characteristic of the present invention is that polymer beads and perfume base are added respectively personal care composition. For purposes of the invention, in one embodiment, polymer beads and perfume base are added respectively in the matrix of formation system, if the total amount of these components combines with the matrix of the discrete component of conduct. Specifically, before two kinds of materials and matrix combination, should substantially there be chemical interaction between these two kinds of materials. Therefore, can in the independent time and/or from independent container and/or with independent storage or send mode, these polymer beads and perfume base be added matrix. These polymer beads and perfume base even can before the matrix that forms system be combined, be mixed together, if they with these materials before the matrix of formation system contacts between substantially do not have chemical interaction.

The non-cationic monomer

This non-cationic monomer can be the monomer that contains hydrophobic grouping. This hydrophobic grouping can be selected from non-hydroxyl group, non-cationic group, non-anionic group, non-carbonyl group and/or non-hydrogen bond group, more preferably is selected from alkyl, cycloalkyl, aryl, alkaryl, aralkyl and composition thereof. The non-cationic monomer can be the hydroxyl monomer. This non-cationic monomer can be the monomer that contains anionic group.

The non-limiting example of suitable non-cationic monomer comprises, but be not limited to, methyl methacrylate, methyl acrylate, ethyl acrylate, acrylic acid n-propyl, isopropyl acrylate, n propyl methacrylate, EMA, isopropyl methacrylate, n-butyl acrylate, isobutyl acrylate, isobutyl methacrylate, n-BMA, methacrylic acid, acrylic acid, acrylamide, Methacrylamide, styrene, AMS, acrylic acid benzyl ester, EHA, hydroxyethyl acrylate, acrylic acid hydroxypropyl ester, methacrylic acid hydroxyethyl ester, hydroxypropyl methacrylate, acrylic acid hydroxy butyl ester, hydroxyethyl methacrylate butyl ester, polyalkylene glycol acrylate ester, vinethene, ketenes, vinyl acetate, vinylphenol, acylamino--2-methyl propane sulfonic acid, sulfonic acid vinyl acetate, propionate, methallylsulfonic acid and N-vinyl formamide.

Cationic monomer

Cationic monomer of the present invention comprises the cation unit. For purposes of the invention, term " cation unit " is defined as a part, when this part is introduced in the polymer particles kernel structure of the present invention, can keeps cationic charge, wherein the scope of pH value is about 2 to about 8. This cation unit needn't be by protonated in about 2 each pH value to about 8 scopes. The non-limiting example that comprises the unit of cationic moiety comprises the cation unit with following formula:

Each R wherein¹、R ²And R³Be independently selected from hydrogen, C₁To C₆Alkyl and composition thereof, preferred hydrogen, C₁To C₃Alkyl, more preferably, hydrogen or methyl. T is selected from group replacement or unsubstituted, saturated or unsaturated, straight or branched, its be selected from alkyl, cycloalkyl, aryl, alkaryl, aralkyl, heterocycle, silicyl, nitro, halogen, cyano group, sulfonate radical, alkoxyl, ketone group, ester, ether, carbonyl, acylamino-, amino, glycidyl, carbonate, carbamic acid root, carboxyl and alkoxy carbonyl group, with and composition thereof. Z is selected from :-(CH₂)-、(CH ₂-CH＝CH)-、-(CH ₂-CHOH)-、(CH ₂-CHNR ₄)-、 -(CH ₂-CHR ⁵-O)-and composition thereof, preferred-(CH₂)-、R ⁴And R⁵Be selected from hydrogen, C₁To C₆Alkyl and composition thereof, preferred hydrogen, methyl, ethyl and composition thereof; Z is selected from about 0 to about 12 integer, and preferred about 2 to about 10, and more preferably from about 2 to about 6. A is NR⁶R ⁷Or NR⁶R ⁷R ⁸, each R wherein⁶、R ⁷And R⁸, when existing, be independently selected from H, C₁- C ₈The straight or branched alkyl, have the alkylene oxide group of following formula:

                        -(R ⁹O) _yR ¹⁰

R wherein⁹C₂-C ₄Straight or branched alkylidene and composition thereof; R¹⁰Be hydrogen, C₁-C ₄Alkyl and composition thereof; Y is 1 to about 10. Preferred R⁶、R ⁷And R⁸, when existing, be hydrogen, C independently₁To C₄Alkyl. Alternatively, NR⁶R ⁷Or NR⁶R ⁷R ⁸Can form heterocycle, this heterocycle contains 4 to 7 carbon atoms, not necessarily contains other hetero atom, not necessarily condense into a phenyl ring, and not necessarily by C₁To C₈Alkyl and/or acetate replace. Suitable replacement and the embodiment of unsubstituted heterocycle are, indyl, isoindolinyl imidazole radicals, imidazolinyl, piperidyl pyrazolyl, pyrazolinyl, pyridine radicals, piperazinyl, pyrrolidinyl, guanidine radicals, amidino groups, chinidine base, thiazolinyl, morpholinyl and composition thereof, wherein preferred morpholine and piperazinyl.

The non-limiting example of the cationic monomer that the present invention is suitable comprises, but be not limited to acrylic acid dimethylamino Arrcostab, especially dimethylaminoethyl methacrylate, vinyl pyrrolidone, vinyl imidazole based compound, the vinethene that contains dialkyl amido, vinylpyridine, alkyl acrylamide and dialkyl aminoalkyl acrylamide.

Cross-linking monomer

This cross-linking monomer can be present in polymer beads of the present invention. The non-limiting example of suitable cross-linking monomer comprises, but be not limited to, diacrylate, two (methacrylate), diacrylate diethylene glycol (DEG) ester, divinylbenzene, divinyl ether, two (methacrylic acid) glycol ester, pentaerythritol triacrylate, polyene propyl group sucrose, trivinylbenzene, divinyl toluene, trivinyl toluene, two (methacrylic acid) triethyleneglycol ester, two (methacrylic acid) tetraethylene glycol ester, allyl methacrylate, diallyl maleate, maleic acid triallyl and diacrylate 1,4-butanediol ester, maleic acid triallyl, diacrylate 1,2-glycol ester, diacrylate 1, ammediol ester, diacrylate 1,6-hexylene glycol ester.

Emulsifying agent and/or colloidal stabiliser

It is known in the art being used for suitable emulsifying agent of the present invention and/or colloidal stabiliser. The non-limiting example of this emulsifying agent and/or colloidal stabiliser comprises, but be not limited to, castor oil-base aminopropyl trimethyl dimethyl ester ammonium sulfate, cocoyl amyl group ethoxyl methyl dimethyl ester ammonium sulfate, cocoyl two (2-ethoxy) ammonio methacrylate, softex kw, cetylpyridinium chloride, tristerin, the amino ethyl diethylamide of stearoyl, the oleyl amine of ethoxylation, the fatty amine of ethoxylation, the season fatty amine of ethoxylation, the fatty alcohol of ethoxylation, sorbitan monostearate, polysorbate, stearate, dodecyl sodium sulfate, nonoxinol ammonium sulfate, DTAB, NaLS, sodium laurate, gelatin, polyvinyl alcohol, the starch of aminomethylation, poly-(vinyl alcohol-vinyl acetate) copolymer, the cellulose of modification, the cellulose of this modification is such as, carboxymethyl cellulose, methylcellulose, hydroxyethylcellulose, polyoxyethylene, polyvinylpyrrolidone, the copolymer of polyoxyethylene-poly-oxypropylene polyoxyethylene, the dimethyl siloxane of polyethers-modification and polyethers-alkyl-dimethylsiloxane copolymer, cationic silicone and polyimides.

Colloidal stabiliser can be used to keep the stability of particle dispersion, especially to larger sized particle. Suitable colloidal stabiliser comprises, but be not limited to, the polyaziridine of propylene oxide-ethylene oxide copolymer or oxirane-propylene oxide grafting, polyoxyethylene (X) iso-octyl phenyl ether, wherein X is polyester terephthalate block copolymer, polyvinylpyrrolidone, the polyvinylpyrrolidone of 20 to 80 integer, alcohol ethoxylate, polyethoxylated and the copolymer that contains vinylpyrrolidone.

Initator

The suitable initator that is used for polymerization of the present invention is known in the art. Embodiment comprises; but be not limited to, sodium peroxydisulfate and azo initiator, as; 2; 2 '-azo two (2-methyl propanamide) dihydrochloride, 2,2 '-azo two (2-amidine propane) dihydrochloride, 2,2 '-azo, two (N; N '-dimethylene NSC 18620) dihydrochloride, 2; 2 '-azo two (2-methylbutyronitrile), 2,2 '-azo two (4-methoxyl group-2,4-methyl pentane nitrile, 2-(carbamoyl azo)-isobutyronitrile.

Personal care composition

Perfume polymeric particles of the present invention can be introduced into one or more personal nursing auxiliary elements, to form personal care composition. Personal care composition of the present invention can be any suitable form, for example, and liquid, gel, foam, paste, strip, sheet, Powdered and graininess. The preferred form of the present invention is liquid. The product form of this personal care composition can comprise clean body product, shampoo, hair and/or health conditioner, pet hair cleaning agent and/or conditioner.

In addition, except as application as the washing-off type of focus of the present invention, the application of leave can also be introduced polymer beads of the present invention and/or perfume polymeric particles. It preferably can be the product that contains by weight greater than 10% moisture (water).

Scheme III (directly using):

According to indirectly using identical program, except TS₀Not dilute with water or rinsing of aliquot. In at the appointed time any one is from TS_nThe quantity of any PRM that obtains in the head space greater than on corresponding time point from TS_cDuring the amount of the identical PRM that head space obtains, can confirm the growth life-span beneficial effect of concrete polymer beads (PP). Use for direct adding, when being present in perfume delivery systems, this polymer beads can have contribution to the release characteristic curve of " graduation " perfume base. This initial head space aggregate value of PRM that can cause having PP to exist is lower than the head space aggregate value that does not have PP to exist. Yet at first or time point subsequently can observe and increase the life-span beneficial effect. Preferably, polymer beads of the present invention can increase the Kovat exponential quantity less than the life-span of 1700 PRM, and more preferably can with the Kovat exponential quantity less than the Service life of 1500 PRM to than Kovat index greater than the larger limit of 1700 PRM.

Following table has proved this class result, and this result can be available from the life test of directly using. This data acknowledgement PRM¹(time point at t=6 hour, TS_nReference area＞TS_cReference area) and PRM²(on the time point of t=2 and 6 hours, TS_nReference area＞TS_cReference area) the growth life-span beneficial effect in the presence of polymer beads (PP).

	Contain and do not contain the HSGC reference area of the beneficial agent of PP
							PRM 1(KI＝1033)		PRM 2(KI＝1122)		PRM 3(KI＝1770)
	Time (h)	TS c	TS n	TS c	TS n	TS c							TS n
2							3000	2500	20	1000	850	700
	6	750	1500	ND	150	25							ND
24							ND	50	ND	ND	ND	ND

ND=does not detect.

In addition, except as application as the washing-off type of focus of the present invention, the application of leave can also be introduced polymer beads of the present invention and/or perfume polymeric particles.

It preferably can be the product that contains by weight greater than 10% moisture (water). This perfume polymeric particles can be present in this personal care composition with any suitable content. It is typically with by the weighing scale at least 0.1% of described personal care composition, and preferred about 0.1% to about 20%, and more preferably from about 1% to about 10% content exists. Except this perfume polymeric particles, the expectation also introduce a kind of independently, water miscible electropolymer component. Also the charge density that has of preferred polymers is at least about 0.4meq/gm and less than about 7meq/gm.

In addition, also provide a kind of perfume polymeric particles is deposited on the method for Person's skin, hair or nail, the method may further comprise the steps: personal care composition described herein is applied to skin, hair and/or nail, and with its flush away.

The present invention can be rinse-off personal care compositions, it can be deposited on spices the hair of Person's skin and/or people and/or pet effectively, this perfume molecules amount is less than about 200, and/or boiling point less than about 250 ℃ and/or ClogP less than about 3, and/or the Kovats index value is less than about 1700.

According to the present invention, personal care composition of the present invention also comprises cation and/or anionic polymer except comprising perfume polymeric particles, preferably include the polymer that can improve deposition effect, and/or conventional personal nursing auxiliary element.

Term used herein " is applicable to Person's skin " and refers to described composition or component wherein and is applicable to contact Person's skin and do not have unusual toxicity, incompatibility, unstability, allergic reaction etc.

Term used herein " water-soluble " refers to that polymer is water-soluble in this composition. Generally speaking, at 25 ℃, this polymer by the weighing scale of described aqueous solvent 0.1%, preferred 1%, more preferably 5%, most preferably should be soluble under 15% the concentration.

The personal nursing auxiliary element

Deposited polymer

Personal care composition of the present invention can comprise deposited polymer, and this polymer is conducive to the deposition of perfume polymeric particles. These deposited polymers can be anionic polymer, cationic polymer, non-ionic polymers and/or amphoteric ion polymer.

In one embodiment, this personal care composition also comprises the cationic deposition polymer except comprising anionic polymerisation composition granule and/or perfume polymeric particles. What expect is this cationic deposition polymer, and the anionic polymerisation composition granule, and/or perfume polymeric particles, before being added into personal care composition, can be concentrated in together.

Composition of the present invention can comprise enough high-cation charge density " cationic deposition polymer " (CDP), with the deposition effect of Effective Raise solid particulate components described herein. On the pH value of the personal care composition that wish is used, the cationic charge density of suitable cationic polymer is at least about 0.4meq/gm, is preferably at least about 0.7meq/gm, more preferably at least about 0.9meq/gm, and preferably less than about 7meq/gm, be more preferably less than 5meq/gm, the common scope of its pH value be about 2 to about 9, preferred about 4 to about 8. The mean molecule quantity of the cationic polymer that these are suitable is generally about 10,000 to about 1,000 ten thousand, preferred about 50,000 to about 500 ten thousand, more preferably from about 100,000 to about 300 ten thousand. " cationic charge density " of term polymer used herein refers to form the ratio of the molecular weight of the monomeric unit Shangyang ionic charge number of polymer and described monomeric unit. Cationic charge density multiply by polymer molecular weight and has determined sites of positive charge number on given polymer chain.

In the personal care composition concentration of cationic polymer for by described personal care composition weighing scale about 0.05% to about 3%, preferred about 0.075% to about 2.0%, more preferably from about 0.1% to about 1.0%. In this personal care composition, the weight ratio of cationic deposition polymer and perfume polymeric particles is about 2: 1 to about 1: 100, preferred about 1: 1 to about 1: 50, and more preferably from about 1: 1 to about 1: 30.

The cationic deposition polymer that is used for personal care composition of the present invention comprises the cation nitrogen moiety, as, the protonated amino part of quaternary ammonium salt or cation. This cation protonated amines can be primary amine, secondary amine or tertiary amine (preferred secondary amine or tertiary amine), and it depends on concrete kind and the selected pH value of this personal care composition. The counter ion of any anion can use with the cationic deposition polymer, as long as this polymer is preferred, in personal care composition, or in the coacervate phase of personal care composition, keep water-soluble, and as long as the basis of this counter ion and this personal care composition is compatible at physics and chemistry, or not performance, stability or the aesthetic characteristic of other undue weakening product. The non-limiting example of above-mentioned counter ion comprises halide ion (such as chlorion, fluorine ion, bromide ion, iodide ion), sulfate radical and methyl esters sulfate radical.

The cation nitrogen moiety of cationic deposition polymer exists with the substituting group of its whole monomeric units usually, or more typically, exists with the substituting group of its partial monosomy unit. Therefore, the cationic deposition polymer that is used for personal care composition comprises homopolymers, copolymer, terpolymer etc., and this polymer is the monomeric unit that quaternary ammonium salt or cationic amine replace, not necessarily with this paper indication non-cationic monomer, as, spacer monomers combines. The non-limiting example of this polymer is described in the CTFA Cosmetic Ingredient Dictionary of Estrin, Crosley and Haynes volume, the third edition, (The Cosmetic, Toiletry, and Fragrance Association, Inc., Washington, D.C. (1982)), it is described and introduces the present invention for your guidance.

Be used for preferred sedimentation time of suitable deposited polymer of personal cleaning compositions described herein less than sedimentation time of same combination when not adding deposited polymer, such as test by following flocculation/sedimentation detection.

Flocculation/sedimentation test

4 gram net products are positioned over (Corning part number #430304 or similar products) in the 50ml conical bottom centrifuge tube, and with 36 distilled water dilutings that restrain. Then this test tube is added a cover and with forced oscillation until all products be dispersed. This should be zero-time. Then centrifuge tube is stood vertically. Because product contains polymer beads, this system is because the dispersion of polymer beads becomes opaque. Be screening polymeric system and concrete interpolation order, have and do not have polymer or by different adding methods each batch of material, in this is tested, be produced and compare. Preferred polymer and interpolation sequentially cause these particles with fast time flocculation, be generally approximately less than 30 minutes, and its any flocculation time is all less than the flocculation time of the same combination that does not contain polymer, or the flocculation time of the composition by different adding method gained, this shows suitable deposited polymer or interpolation order. Can resemble this polymer beads and be assembled by observing flocculation in the formation in the sample hollow white area of diluting, and from almost migrating out the even opaque suspension at first. When developing into an apparent degree, required time is considered to flocculation time like this.

The suitable cationic deposition polymer that is used for this personal care composition can comprise polysaccharide polymer, and for example, the cationic polysaccharide polymer that cationic cellulose derivative and cationic starch derivative are suitable comprises those that meet following formula:

Wherein A is the anhydroglucose residue, such as starch or cellulose anhydroglucose residue; R is alkylidene oxyalkylene, polyoxyalkylene or hydroxy alkylidene and their combination; R¹、R ²And R³Be alkyl, aryl, alkylaryl, aryl alkyl, alkoxyalkyl or alkoxy aryl independently, each group comprises at most about 18 carbon atoms, and the total number of carbon atoms of each cationic moiety (is R¹ R ²And R³Middle carbon number sum) is preferably about 20 or still less; And X is aforesaid anionic counter ion. Cation substitution value in these polysaccharide polymers typically is about 0.01 to 1 cation group of every anhydroglucose unit.

Preferred cationic cellulose polymer is the salt of hydroxyethylcellulose and leptodactyline substituted epoxide reaction gained, industrial quarters (CTFA) is called polyquaternium 10, and derive from Amerchol Corp. (Edison, N.J., USA): charge density is that 1.25 meq/g and molecular weight are about 900,000 Polymer JR30M, charge density is that 1.25meq/g, molecular weight are that about 400,000 Polymer JR400 and charge density are 1.9, molecular weight is about 1,250,000 Polymer KG30M. The cationic cellulose of other adequate types comprises the quaternary ammonium salt of the epoxide reaction resulting polymers that hydroxyethylcellulose and lauryl dimethyl ammonium replace, and industrial quarters (CTFA) is called polyquaternium 24.

Other suitable cationic polymer comprises cationic guar derivative, for example, Rhaball Gum CG-M 8M, its specific embodiment comprise and be purchased the C17 from the Jaguar of Rhone-Poulenc company, its charge density be 0.9 and molecular weight be about 2,200,000. Other suitable cationic polymer comprises and contains the quaternary nitrogen cellulose ether, and its some embodiment are described in United States Patent (USP) 3,962, and in 418, it is described and introduces the present invention for your guidance. Other suitable cationic polymer comprises cellulose copolymer, guar gum and the starch of etherificate, and its some embodiment are described in United States Patent (USP) 3,958, and in 581, it is described and introduces the present invention for your guidance.

The clean surface activating agent

Personal care composition of the present invention can comprise the surfactant that is applicable to hair or skin. Suitable surfactant used herein comprise any known or other be applicable to the effective nursing surfactant of hair or skin, and and composition in other basis compatible. Suitable clean surface activating agent comprises anion, nonionic, cation, amphion or amphoteric surfactant, or their combination.

Personal care composition of the present invention preferably comprises by weight about 0.1% to about 50%, and more preferably from about 4% to about 30%, even 5% to about 25% clean surface surfactant composition more preferably from about.

The anion surfactant that is applicable to personal care composition comprises alkyl and alkyl ether sulfate. These materials have respectively formula ROSO₃M and formula RO (C₂H ₄O) _xSO ₃M, R wherein contain about 8 alkyl or alkenyls to about 24 carbon atoms, and x is 1 to 10, M to be water-soluble cationic, for example ammonium, sodium, potassium or triethanolamine. Typically, alkyl ether sulfate is oxirane and contain about 8 products to the monohydric alcohol condensation of about 24 carbon atoms. Preferably, R has about 10 to about 18 carbon atoms in alkyl sulfate and alkyl ether sulfate. Alcohol derives from fat, for example coconut oil or butter, or made by synthetic. The preferred laruyl alcohol of the present invention and the straight chain alcohol that derives from coconut oil. These alcohol and mol ratio be about 1 to about 10, be preferably about 3 to about 5 and especially be about 3 reacting ethylene oxide, for example, have the molecular species mixture of 3 moles of ethylene oxide to be made into sulfate in average every mol of alcohol of gained and be neutralized.

The specific embodiment that can be used for the alkyl ether sulfate of personal care composition comprises cocounut oil alkyl triethylene glycol ether sodium sulfate salt and ammonium salt, tallow alkyl triethylene glycol ether sodium sulfate salt and ammonium salt, and tallow alkyl six ethylene oxide sodium sulfate salt and ammonium salts. Highly preferred alkyl ether sulfate is those of mixture that comprise individualized compound, and the mean alkyl chain length that described mixture has is about 10 to about 16 carbon atoms, and average degree of ethoxylation is about 1 to about 4 moles oxirane.

Other suitable anion surfactant comprises organic water soluble salt, has general formula [R¹-SO ₃-M] the sulfuric acid reaction product, R wherein¹Be selected from and have about 8 to about 24, the preferred about 10 saturated aliphatic hydrocarbyls to the straight or branched of about 18 carbon atoms; And M is cation. Preferred embodiment comprises the salt of methane series hydrocarbon and organic sulfur acid reaction product, described methane series hydrocarbon comprises about 8 to about 24 carbon atoms, preferred about 10 different, new, outer (ineso-) and normal paraffin hydrocarbons and sulfonating agents to about 18 carbon atoms, for example, according to known method of sulfonating, comprise the SO that bleaching and hydrolysis obtain₃、H ₂SO ₄And oleum. Preferred sulfonation C_10-18The alkali metal salt of normal paraffin hydrocarbons and ammonium salt.

Other suitable anion surfactant embodiment is the product that aliphatic acid is used the isethionic acid esterification and neutralized with NaOH, and for example, wherein fatty acid source is in coconut oil; The sodium salt of the fatty acid amide of methyl taurate or sylvite, for example, wherein fatty acid source is in coconut oil. Other this suitable analog anion surfactants is described in United States Patent (USP) 2,486, and 921, United States Patent (USP) 2,486,922 and United States Patent (USP) 2,396,278, it is described and introduces the present invention for your guidance.

In addition, other suitable anion surfactant is Succinamate, embodiment comprises N-disodium octadecyl sulfosuccinate, dodecyl sulfosuccinic acid two ammoniums, N-(1,2-dicarboxyl ethyl)-N-octadecyl sulfosuccinic acid four sodium, sodium sulfosuccinate diamyl ester, sodium sulfosuccinate dihexyl ester and sodium sulfosuccinate dioctyl ester.

Other suitable anion surfactant comprises having the about 12 alkene sulfonic acid esters to about 24 carbon atoms. Term used herein " alkene sulfonic acid ester " refers to a compounds, this compounds can be prepared as follows: with the SO 3 sulfonated alpha-olefin that does not cooperate, then this acidic reaction mixture neutralizes, with this understanding, so that all sulfones that produce in the reaction all are hydrolyzed to produce corresponding hydroxyl paraffin sulfonate. This sulfur trioxide can be liquid or gas, and usually but not necessarily with the inert diluent dilution, for example when using with liquid form, uses liquid SO₂, the dilution such as chlorohydrocarbon, perhaps when using with gas form, with air, nitrogen, gaseous state SO₂Deng dilution.

The alpha-olefin that can derive the alkene sulfonic acid ester is monoolefine, and it has about 12 to about 24 carbon atoms, and preferred about 14 to about 16 carbon atoms. Preferably, they are linear alkenes.

Except real alkene sulfonic acid root and part of hydroxyl alkanesulfonic acid root, this alkene sulfonic acid root also can comprise a small amount of other material, alkene disulfonic acid root for example, this depends on starting olefin and the character of impurity and the side reaction situation in the sulfonating reaction in the ratio, olefin feedstock of reaction condition, reactant.

The another kind of anion surfactant that is applicable to personal care composition of the present invention is alpha-alkoxy base alkanesulfonic acid ester, and it meets following formula:

R wherein₁To have about 6 straight chained alkyls to about 20 carbon atoms, R₂Be to have about 1 low alkyl group to about 3 carbon atoms, preferred 1 carbon atom, and M is water-soluble cationic.

Other surfactant that is applicable to this paper personal care composition is described in " McCutcheon ' s Emulsifiers and Detergents " that annual in 1989 is published by M.C.Publishing Co., and United States Patent (USP) 3,929,678, its description is incorporated herein by reference.

The preferred anion surfactant that is used for this paper personal care composition comprises ammonium lauryl sulfate; laureth ammonium sulfate; the lauryl sulfate triethylamine; laureth sulfuric acid triethylamine; triethanolamine lauryl sulfate; laureth sulfuric acid triethanolamine; lauryl sulfate monoethanolamine; laureth sulfuric acid MEA; lauryl sulfate diethanolamine; laureth sulfuric acid diethanol amine, Glyceryl Monolaurate sodium sulphate, NaLS; sodium laureth sulfate; lauryl potassium sulfate, laureth potassium sulfate, sodium lauryl sarcosinate; sodium lauroyl sarcosine; the methyl amimoacetic acid lauryl, cocoyl methyl amimoacetic acid, cocoyl ammonium sulfate; dodecane acyl group ammonium sulfate; sodium cocosulfate, lauroyl sodium sulphate, cocoyl potassium sulfate; lauryl potassium sulfate; triethanolamine lauryl sulfate, triethanolamine lauryl sulfate, cocoyl sulfuric acid monoethanolamine; lauryl sulfate monoethanolamine; the tridecyl benzene sulfonic acid sodium salt, dodecyl base benzene sulfonic acid sodium salt, and their combination.

The amphoteric surfactant that is applicable to this paper personal care composition comprises those that extensively are described as aliphatic secondary amine and tertiary amines derived thing, wherein aliphatic group can be straight or branched, and one of them aliphatic substituting group comprises about 8 to about 18 carbon atoms, with a group that contains the anionic water solubilising, for example, carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical. The non-limiting example of these surfactants comprises 3-dodecyl-alanine sodium, 3-dodecyl amino propane sulfonic acid sodium, sodium lauryl sarcosinate, N-alkyl taurine; for example with lauryl amine and isethionic acid sodium according to United States Patent (USP) 2; 658; 072 reaction that proposes be prepared those, the high alkyl-aspartic acid of N-; for example according to United States Patent (USP) 2; 438; those of the 091 reaction preparation that proposes; and product description is in United States Patent (USP) 2; 528; 378, these formulations and description all are introduced into the present invention for your guidance.

Other suitable amphoteric surfactant comprises alkali metal salt, alkali salt, ammonium salt and three alkanol ammonium salts of cocoyl both sexes acetic acid, cocoyl both sexes oxalic acid, cocoyl both sexes propionic acid, cocoyl both sexes dipropionic acid, both sexes acetic acid (such as N-lauroyl amido ethyl-N hydroxyethyl acetic acid or cocounut oil both sexes acetic acid and their mixture).

Suitable amphoteric surfactant also has monovalence and the divalent salts of soap-aliphatic acid.

Cationic surfactant also can be used for this paper personal care composition, but general little preferred, and by weight of the composition, content is preferably less than about 5%.

The suitable ionic surfactant pack that is used for this paper personal care composition is drawn together, the condensation product of alkylene oxide group and organic hydrophobic compound, and in fact it can be aliphatic series or alkyl aromatic. Preferred nonionic surfactants comprises:

1) polyethylene oxide condensation compound of alkyl phenol, contain about 6 to the alkyl phenol of about 20 carbon atom alkyls and the condensation product of oxirane as having in the straight or branched configuration, the oxirane of participating in reaction quantitatively equals every mole of alkyl phenol needs about 10 to about 60 moles oxirane;

2) non-ionic surface active agent, it is derived from by propylene oxide and the product of 1,2-reacting ethylenediamine gained and the product of ethylene oxide condensation;

3) in the configuration of straight chain or side chain, have about 8 to the aliphatic alcohol of about 18 carbon atoms and the condensation product of oxirane, for example, every mole of coconut alcohol contains the about 10 coconut alcohol ethylene oxide condensates to about 30 moles oxirane, and coconut alcohol partly has about 10 to about 14 carbon atoms;

4) corresponding to the long chain tertiary amine oxide of following general formula:

R wherein₁For comprising about 8 alkyl to about 18 carbon atoms, alkenyl or monohydroxy alkyl, 0 to about 10 ethylene oxides part and 0 to about 1 glyceryl; And R₂And R₃For comprise about 1 to the group and 0 of about 3 carbon atoms to about 1 hydroxyl, for example methyl, ethyl, propyl group, ethoxy or hydroxypropyl;

5) corresponding to the long-chain phosphine oxides of following general formula:

Wherein R comprises alkyl, alkenyl or chain length to have the about 8 monohydroxy alkyl groups to about 18 carbon atoms, 0 to about 10 ethylene oxides part and 0 to about 1 glyceryl, and R ' and R " respectively do for oneself and comprise about 1 alkyl or monohydroxy alkyl group to about 3 carbon atoms.

6) long-chain dialkyl sulphoxide, it comprises one about 1 to short-chain alkyl or the hydroxyl alkyl of about 3 carbon atoms (being generally methyl), and comprise a long hydrophobic chain, hydrophobic chain comprise alkyl, alkenyl, hydroxyl alkyl or have about 8 to about 20 carbon atoms, 0 to 10 ethylene oxide part and 0 to about 1 glyceryl ketone alkyl;

7) alkyl polysaccharide (APS) surfactant, for example be described in United States Patent (USP) 4,565, alkyl polyglycoside in 647, it has about 6 to the hydrophobic group of about 30 carbon atoms and as the polysaccharide (such as poly glucoside) of hydrophilic group, and optional has a polyalkylene oxides that connects hydrophobic and hydrophilic segment, wherein alkyl (being hydrophobic part) can be saturated or unsaturated, side chain or non-side chain, that do not replace or replace (such as, the ring with hydroxyl or ring-type); With

8) polyethylene glycol (PEG) glyceryl fatty ester for example has formula R (O) OCH₂CH(OH)CH ₂(OCH ₂CH ₂) _nThose of OH, wherein n be about 5 to about 200, be preferably about 20 to about 100, and R has about 8 aliphatic hydrocarbyls to about 20 carbon atoms.

The zwitterionic surfactant that is applicable to this paper personal care composition comprises, extensively be described as those of derivative of aliphatic quaternary ammonium, Phosphonium and sulfonium compound, wherein this aliphatic group can be straight or branched, and one of them aliphatic substituting group contains has an appointment 8 to about 18 carbon atoms, and one contains anionic group, for example, carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical. These zwitterionic surfactants comprise as shown in the formula the expression those:

R wherein²Comprise alkyl, alkenyl or hydroxyalkyl, this hydroxyalkyl have about 8 to about 18 carbon atoms, 0 to about 10 ethylene oxides part and 0 to about 1 glyceryl; Y is selected from nitrogen, p and s atom; R³To comprise about 1 alkyl or monohydroxy alkyl to about 3 carbon atoms; When Y was sulphur atom, X was 1, and when Y was nitrogen-atoms or phosphorus atoms, X was 2; R⁴Be to have about 1 alkylidene or hydroxyl alkylidene to about 4 carbon atoms, and Z is the group that is selected from carboxylate radical, sulfonate radical, sulfate radical, phosphonate radical and phosphate radical.

Other zwitterionic surfactant that is applicable to this paper personal care composition comprises betaine, comprises the betaine of high alkyl, as, the coco dimethyl carboxymethyl betaine, cocoamidopropyl, coco betaine, lauramido propyl betaine, oil-based betaine, the lauryl dimethyl carboxymethyl betaine, lauryl dimethyl α-carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, two (2-ethoxy) carboxymethyl betaines of lauryl, two (2-hydroxypropyl) carboxymethyl betaines of stearyl, oleyl dimethyl-γ-carboxylic CAB, and two (2-the hydroxypropyl)-α of lauryl-carboxyethyl betaine. The representative of sulfobetaines be coco dimethyl sulfopropyl betaine, stearic dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, bay two-(2-hydroxyl ethyl) sulfopropyl betaine etc.; Amido betaine and amino sulfobetaines, wherein RCONH (CH₂) ₃Group links to each other with nitrogen-atoms in the betaine, and they also can be used for the present invention.

Conventional personal nursing auxiliary element

Personal care composition of the present invention also can comprise other personal nursing auxiliary element, and this composition can improve physics, chemistry, beauty treatment or the aesthetic properties of composition, maybe can be used as additional " activity " component when being deposited on skin. Composition also further comprises auxiliary inert fraction. Many such auxiliary elements become known in the personal care composition, and can be used in the topical composition of the present invention, precondition is that such auxiliary substance and base substance described in the invention are compatible, or does not exceedingly weaken the performance of product.

Those are considered to can be used for the material in the cosmetic product to this auxiliary element the most typically, and it is described in the reference book, as, CTFA Cosmetic Ingredient Handbook, second edition, The Cosmetic, Toiletries, and Fragrance Association, Inc.1988,1992. The non-limiting example of this auxiliary element comprises anticorrisive agent (for example, propylparaben), deodorant, antiseptic, aromatic, deodorizing spices, colouring agent or dyestuff, thickener, sensitizer, sun-screening agent, surfactant or emulsifying agent, gelling agent or other suspending agent, pH modifier, cosolvent or other additional solvent, emollient, pharmaceutically active agents, vitamin and their combination.

Personal care composition of the present invention not necessarily comprises one or more this auxiliary elements. The embodiment of this constituents comprises: enzyme, grinding agent, the scurf agents for defoliating, absorbent, aesthetic components, as, aromatic, pigment, coloring agent/colouring agent, essential oil, the skin sensitizer, astringents etc. (for example, caryophyllus oil, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, the witch hazel distillate), anti-acne agents (as, resorcinol, sulphur, salicylic acid, erythromycin, zinc etc.), anti-caking agent, cut infusion, additional antiseptic (for example, butyl carbamic acid iodine propyl ester), antioxidant, adhesive, bio-additive, buffer, swelling agent, chelating agent, chemical addition agent, colouring agent, beauty treatment property astringent, beauty treatment property biocide, denaturant, the medicine astringent, external-use analgesic, film forming agent or material, for example, be used for to help the film-shaped of composition to become second nature and the polymer of compatibility (for example, the copolymer of eicosylene and vinyl pyrrolidone), NMF, opacifiers, pH adjusting agent, propellant, reducing agent, sequestering agent, skin whitener (or brightener) (for example, hydroquinones, kojic acid, ascorbic acid, magnesium ascorbyl phosphate, the ascorbic acid aminoglucose), skin conditioning agent (wetting agent, comprise mix reagent and occludent), skin (is for example consoled agent and/or rehabilitation agent, panthenol and derivative are (for example, the ethyl panthenol), aloe, pantothenic acid and derivative thereof, allantoin, bisabolol, with dipotassium glycyrrhizinate salt, skin treatment agents, comprise and preventing, delay, suppress, and/or the reagent of elimination wrinkle of skin (for example, 'alpha '-hydroxy acids, as, lactic acid and glycolic, and beta-hydroxy acid, as, salicylic acid), thickener, hydrocolloid, special zeolite, with vitamin and derivative (for example, tocopherol thereof, tocopherol acetate, β-carrotene, retinoic acid, retinal, biostearin, palmitic acid is looked the sulphur ester, nicotinic acid, niacinamide etc.). Personal care composition of the present invention can comprise carrier component, for example known in the art those. Such carrier can comprise one or more compatible liquid or solid filling diluent or carriers that are suitable for being administered to skin or hair.

Personal care composition of the present invention can randomly contain one or more these auxiliary elements. Preferred personal care composition randomly comprises a kind of useful treatment component of safe and effective amount, this component comprises the treatment beneficial agent, and this beneficial agent is selected from vitamin compound, conditioner, skin treatment agents, anti-acne activating agent, crease-resistant activating agent, anti-atrophoderma activating agent, agent having ahtiphlogistic activity, local anesthetic, artificial tanned activating agent and promoter, antibacterial activity agent, antifungal activity agent, sunscreen actives, antioxidant, scurf agents for defoliating and their combination. Used herein, " safe and effective amount " refers to be enough to significantly impel the compound of positive effect or beneficial effect or the amount of component, but enough hang down again simultaneously to avoid serious side effect (for example, unsuitable toxicity or allergic reaction), namely, with in good medical care evaluation scope, provide rational effective hazard ratio.

Personal care composition of the present invention also comprises the stabilizing agent of valid density, being stabilized in particle or other water-insoluble materials that exists with discrete form in the personal care composition, or in order to improve the viscosity of composition. This concentration counts about 0.1% to about 10%, preferred about 0.3% to about 5.0% by described personal care composition weight.

Be used for stabilizing agent of the present invention and comprise anionic polymer and non-ionic polymers. Can be used for of the present invention is the crosslinked acrylic acid polymer of polyvinyl such as CTFA carbomer by name, the cellulosic polymer of cellulose derivative and modification such as methylcellulose, ethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, NC Nitroncellulose, cellulose sodium sulfate, sodium carboxymethylcellulose, avicel cellulose, cellulose powder, polyvinylpyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar gum, xanthans, Arabic gum, bassora gum, galactan, carob glue, guar gum, karaya, carrageenan, pectin, agar, temperature cypress seed (Quinces Quince), starch (paddy rice, corn, potato, wheat), algin (algae extract), microbial polymer such as glucan, succinoglucan, Propiram, polymer such as CMS based on starch, the methyl hydroxypropul starch, polymer such as mosanom based on alginic acid, the alginic acid propylene glycol ester, acrylate polymer such as Sodium Polyacrylate, polyethyl acrylate, polyacrylamide, polymine and inorganic water-soluble substances such as spot take off bentonite, Magnesiumaluminumsilicate, LAPONITE, hectorite and silicic acid anhydride.

Molecular weight can be used for the present invention greater than about 1000 PAG. Usefully have those of following general formula:

R in the formula⁹⁵Be selected from H, methyl and composition thereof. Work as R⁹⁵During for H, these materials are the polymer of oxirane, and they also are known as PEO, polyoxyethylene and polyethylene glycol. Work as R⁹⁵During for methyl, these materials are the polymer of expoxy propane, and they also are known as PPOX, polyoxypropylene and polypropylene glycol. Work as R⁹⁵During for methyl, also can be regarded as the various position isomers that can have resulting polymers. In said structure, the mean value of x3 is about 1500 to about 25,000, preferred about 2500 to about 20,000, more preferably from about 3500 to about 15,000. Other useful polymer comprises the polyethylene glycol-propane diols of polypropylene glycol and mixing, or the Pluronic F68 polymer. Can be used for polyethylene glycol polymer of the present invention is PEG-2M, wherein R⁹⁵Be H, and the mean value of x3 is that about 2,000 (PEG-2M is also referred to as Polyox WSR^N-10 derives from Union Carbide, is also referred to as PEG-2,000); PEG-5M, wherein R⁹⁵Be H, and the mean value of x3 is that about 5,000 (PEG-5M is also referred to as Polyox WSR^N-35 and Polyox WSR^N-80, the two all derives from Union Carbide, is also referred to as PEG-5, and 000 and Liquid Macrogol, 000); PEG-7M, wherein R⁹⁵Be H, and the mean value of x3 is that about 7,000 (PEG-7M is also referred to as Polyox WSR^N-750 derives from Union Carbide); PEG-9M, wherein R⁹⁵Be H, and the mean value of x3 is that about 9,000 (PEG 9-M is also referred to as Polyox WSR^N-3333 derives from Union Carbide), and PEG-14 M, wherein R⁹⁵Be H, and the mean value of x3 is that about 14,000 (PEG-14M is also referred to as Polyox WSR^N-3000 derives from Union Carbide).

The very available commercially available viscosity modifier of the present invention comprises carbomer, and commodity are called Carbopol 934, Carbopol 940, Carbopol 950, Carbopol 980 and Carbopol 981, all available from B.F.Goodrich Company; Acrylate/stearyl APEO-20 methacrylate copolymer, commodity are called ACRYSOL 22, derive from Rohm and Hass; The ninth of the ten Heavenly Stems oxygen ethylhydroxyethylcellulose, commodity are called AMERCELL POLYMER HM-1500, derive from Amerchol; Methylcellulose, commodity are called BENECEL; Hydroxyethylcellulose, commodity are called NATROSOL; Hydroxypropyl cellulose, commodity are called KLUCEL; The cetyl hydroxyethylcellulose, commodity are called POLYSURF 67, provide by Hercules; Oxirane and/or expoxy propane based polyalcohol, commodity are called CARBOWAX PEGs, POLYOX WASRs and UCON FLUIDS, provide by Amerchol.

Other auxiliary stabilizer comprises the stabilizing agent of crystallization, and it can belong to acyl derivative, long-chain amino-oxide and their mixture. These stabilizing agents are described in United States Patent (USP) 4,741, and in 855, it is described and introduces the present invention for your guidance. These preferred stabilizing agents comprise the fatty acid ethylene glycol ester, preferably have about 16 aliphatic acid to about 22 carbon atoms. Ethylene glycol stearate more preferably, i.e. monostearate and distearate, but especially comprise the distearate that is lower than about 7% monostearate. Other suitable stabilizing agent comprises the alkanolamide of aliphatic acid, preferably have about 16 to about 22 carbon atoms, more preferably from about 16 to about 18 carbon atoms, its preferred embodiment comprises a stearic glycollic amide, stearic diglycollic amide, a stearic isopropanol amide and stearic acid one glycollic amide stearate. Other long acyl derivative comprises the long-chain ester (such as stearic acid stearyl, cetin etc.) of LCFA; The long-chain ester of long-chain alkanolamide (for example stearmide diglycollic amide distearate, stearmide one glycollic amide stearate); And glyceride (for example glycerol distearate, three (hydroxy stearic acid) glyceride, glycerine three behenates), its commercially available acquisition embodiment is Thixin R, derives from Rheox, Inc.. Except preferred material listed above, long acyl derivative, long-chain carboxylic acid's glycol ester, long-chain amine oxide and long-chain carboxylic acid's alkanolamide also can be used as stabilizing agent.

Other the long acyl derivative that is suitable for use as stabilizing agent comprises N; N-dialkyl acyl Aminobenzoic Acid and its soluble salt are (for example; Na, K); especially N; N-two (hydrogenation) C.sub.16, C.sub.18 and this class butter acylamino-benzoic acid family, it is commercially available from Stepan Company (Northfield; Ill., USA).

The embodiment that is suitable for use as the long-chain amine oxide of stabilizing agent comprises alkyl (C.sub.16-C.sub.22) dimethyl amine oxide, for example stearyl dimethyl amine oxide.

Other suitable stabilizing agent comprises the primary amine that has at least about the fatty moieties of 16 carbon atoms, embodiment comprises palmitamide or octadecylamine, and the secondary amine with two fatty alkyl parts, wherein the fatty alkyl part has separately at least about 12 carbon atoms, and embodiment comprises two palmitamides or two (h-tallow) amine. Other suitable stabilizing agent also comprises two (h-tallow) phthalic acid acid amides, and crosslinked maleic anhydride base-methyl ethylene ether copolymer.

Other suitable stabilizing agent comprises the stabilizing agent of the hydroxyl of crystallization. These stabilizing agents can be aliphatic acid, aliphatic ester or the water-insoluble ceraceous material of fats soap of comprising hydroxyl etc. If the stabilizing agent of the hydroxyl of crystallization exists, by the weighing scale of composition of the present invention, its content is about 0.5% to about 10%, preferred about 0.75% to about 8%, more preferably from about 1.25% to about 5%. Described stabilizing agent in environmental condition down near being undissolved in water under the environmental condition.

The stabilizing agent of the hydroxyl of suitable crystallization comprises:

(i)

Wherein

R ₂Be R₁Or H; R₃Be R₁Or H; R₄Be C_0-20Alkyl; R₅Be C_0-20Alkyl; R₆Be C_0-20Alkyl; R₄+R ₅+R ₆＝C _10-22 And 1≤x+y≤4 wherein;

(ii)

Wherein

R ₇For-R₄(COH) _xR ₅(COH) _yR ₆ And M is Na⁺，K ⁺Or Mg⁺⁺, or H.

The stabilizing agent of some preferred hydroxyls comprises 12-hydroxy stearic acid, 9,10-dihydroxystearic acid, three-9,10-di-hydroxy stearic acid glyceride and three-12-hydroxy stearic acid glyceride (rilanit special is mainly three-12-hydroxy stearic acid glyceride). Most preferably three-12-hydroxy stearic acid glyceride is used for composition of the present invention.

Yet auxiliary element described in the invention will repel basis or the material that any the present invention describes or defines in addition clearly. Yet this should be understood to that composition of the present invention can comprise the additional polymer as auxiliary element, and this polymer is what to separate with deposited polymer, it can with perfume polymeric particles and/or polymer beads premixed.

Using method

Personal care composition of the present invention is used for the nursing of hair and/or skin in a conventional manner, and the solid particle deposition effect of raising and the present invention can be provided other beneficial effect. With being applied to for hair or skin care compositions and methods of effective dose, hair or skin that preferred water is got wet, then flush away. This effective dose scope is generally about 1g to about 50g, and preferably about 1g is to about 20g.

The method that is used for nursing/cleaning hair and skin may further comprise the steps:

A) water is got hair and/or skin wet;

B) personal care composition with effective dose is applied to hair and/or skin; And

C) water with said composition from hair and/or skin flush away.

These steps can be repeated many needed number of times, to obtain desired nursing and particle deposition beneficial effect.

Embodiment

The following example has further described and has illustrated preferred embodiment within the scope of the present invention. The embodiment that provides only is for illustrational purpose, should not be construed as the limitation of the invention condition, is possible because under the condition that does not deviate from the scope of the invention it is carried out many changes.

Shampoo and clean body composition

	Component	1	2	3
					1	Lauryl ether 2EO sodium sulphate	7	7	7
2	Cocoamidopropyl	2	2	2
					3	Sodium lauroyl sarcosine	2	2	3
4	NaLS	3	3	3
					5	Polymer beads-Allianz OPT (ISP and Rohm and Haas)	-	5	5
6	1,3-dihydroxymethyl-5, the 5-dimethyl hydantoin	0.21	0.21	0.21
					7	Ucare KG-30M	0.35	0.35	-
8	Nhance 3169	-	-	0.25
					9	Water	In right amount	In right amount	In right amount
10	Sodium sulphate	1	1	1
					11	Citric acid	Regulate pH	Regulate pH	Regulate pH
12	EDTA	0.15	0.15	0.15
					13	Three (hydroxy stearic acid) glyceride	1.5	1.5	1.5
14	Laurate	0.5	0.5	0.5
					15	Aromatic (suitable composition)	2	2	2

The manufacture method of above-described embodiment：

Surfactant (1-4), EDTA (12), three (hydroxy stearic acid) glyceride (13) and month silicic acid (14) are mixed in container, and be heated to 88 ℃ (190 °F), then make its cooling. When temperature drops to 60 ℃ (140 °F) when following, with 1,3-dihydroxymethyl-5,5-dimethyl hydantoin (6) is sneaked into.

In a different container, make the fully hydration in water (9) of this cationic deposition polymer (7,8), until the limpid and thickness of this solution. Afterwards, Allianz OPT (5) is added to this mixture, and mix. Then, aromatic (15) is added to this container and mixing. After this step, the surfactant mixture that the first step is done in advance adds to this container, and whole materials are fully stirred until level and smooth. Then pH is adjusted to 6.3 and use sodium sulphate with viscosity be adjusted to 7Pa.s (7000cps) and 10Pa.s (10,000cps) between.

Suitable manufacture method

Prepare in the above described manner surfactant mixture. As previously mentioned, also make the cationic deposition polymer hydration. Surfactant is added to the deposited polymer of this hydration, add subsequently aromatic and it is fully mixed. Then Allianz OPT is added to this mixture. Subsequently the pH value is transferred to 6.3 and with sodium sulphate with viscosity transfer to 7Pa.s (7000cps) and 10 Pa.s (10,000cps) between.

The relevant portion of all documents of quoting in detailed Description Of The Invention is incorporated herein by reference; It is to its approval as prior art of the present invention that the quoting of any document not can be regarded as.

Although illustrate and described specific embodiments of the present invention, it will be apparent to those skilled in the art that many other variations and modifications may be made in the case of without departing from the spirit and scope of protection of the present invention. Therefore in additional claims, comprise consciously all such changes and modifications in the scope of the invention.

Claims (12)

1. personal care composition, described personal care composition comprises the personal nursing auxiliary element;

Wherein said composition is characterised in that described personal care composition also comprises the perfume polymeric particles that is selected from anion, nonionic and their combination, and described perfume polymeric particles comprises:

I) be selected from the polymer of anionic polymer, non-ionic polymers and their mixture, wherein said polymer also comprises anionic monomer and non-ionic monomer; With

Ii) comprise the spices of one or more perfume bases, described perfume base has one or more following character:

A) count molecular weight less than 200;

B) boiling point is less than 250 ℃;

C) ClogP is less than 3; With

D) the Kovats index value is less than 1700;

The response factor of wherein said perfume polymeric particles (RF) is at least 1.6.

2. personal care composition as claimed in claim 1, described personal care composition also comprise one or more perfume base of at least 0.1% weight, and wherein the Kovats index value of the described perfume base of at least 25% weight is less than 1700.

3. such as the described personal care composition of aforementioned each claim, wherein said perfume polymeric particles also comprises cationic monomer, and described cationic monomer contains the cation unit with following formula:

Each R wherein¹、R ²And R³Be independently selected from hydrogen, C₁To C₆Alkyl and their mixture; T is selected from and replaces or group unsubstituted, saturated or unsaturated, straight or branched, and described group is selected from alkyl, cycloalkyl, aryl, alkaryl, aralkyl, heterocycle, silicyl, nitro, halogen, cyano group, sulfonate radical, alkoxyl, ketone group, ester, ether, carbonyl, acylamino-, amino, glycidyl, carbonate, carbamic acid root, carboxyl and alkoxy carbonyl group and their mixture; Z is selected from :-(CH₂)-、(CH ₂-CH＝CH)-、 -(CH ₂-CHOH)-、(CH ₂-CHNR ⁴)-、-(CH ₂-CHR ⁵-O)-and their mixture; Z is 0 to 12 integer; A is selected from NR⁶R ⁷、NR ⁶R ⁷R ⁸And their mixture;

Each R wherein⁶、R ⁷And R⁸, when existing, be independently selected from H, C₁-C ₈Straight chain, branched alkyl, have the alkylene oxide group of following formula:

                -(R ⁹O) _yR ¹⁰

And their mixture;

R wherein⁹Be selected from C₂-C ₄Straight chain, branched alkylidene, carbonylic alkyl and their mixture; R¹⁰Be selected from hydrogen, C₁-C ₄Alkyl-carbonyl alkyl and their mixture; Y is 1 to 10.

4. such as the described personal care composition of aforementioned each claim, described personal care composition also comprises the cationic deposition polymer of assembling with described anion perfume polymeric particles, wherein said cationic deposition polymer is selected from flocculation time less than 30 minutes cationic deposition polymer, described in flocculation/sedimentation test.

5. such as the described personal care composition of aforementioned each claim; the described perfume polymeric particles that wherein comprises described anion and non-ionic polymers also comprises the non-cationic monomer; described non-cationic monomer comprises hydrophobic grouping; described hydrophobic grouping is selected from alkyl; cycloalkyl; aryl; alkaryl; aralkyl and their mixture; preferably, described non-cationic monomer is selected from: methyl methacrylate; methyl acrylate; ethyl acrylate; the acrylic acid n-propyl; isopropyl acrylate; n propyl methacrylate; EMA; isopropyl methacrylate; n-butyl acrylate; isobutyl acrylate; isobutyl methacrylate; n-BMA; methacrylic acid; acrylic acid; acrylamide; Methacrylamide; styrene; AMS; the acrylic acid benzyl ester; EHA; hydroxyethyl acrylate; the acrylic acid hydroxypropyl ester; the methacrylic acid hydroxyethyl ester; hydroxypropyl methacrylate; the acrylic acid hydroxy butyl ester; the hydroxyethyl methacrylate butyl ester; the polyalkylene glycol acrylate ester; acylamino--2-methyl propane sulfonic acid; the sulfonic acid vinyl acetate; propionate; methallylsulfonic acid; N-vinyl formamide and NVP; and their mixture.

6. such as the described personal care composition of aforementioned each claim, wherein said anion and non-ionic polymers are insoluble polymer.

7. as the described personal care composition of aforementioned each claim, the ARF of wherein said perfume polymeric particles_LKI/ARF _HKIThe optional ratio is at least 1.2.

8. personal care composition as claimed in claim 7, the wherein ARF that provides of the value of life test I_LKIMore than or equal to ARF_HKIThe value 1.6 times.

9. personal care composition as claimed in claim 7, the wherein ARF that provides of the value of life test II_LKIMore than or equal to ARF_HKIThe value 1.6 times.

10. the method for preparing personal care composition, described personal care composition show to have the aromaticity that strengthens in time on skin and hair, said method comprising the steps of:

A. form the preformed polymer beads that comprises polymer, described polymer is selected from anionic polymer, non-ionic polymers and their mixture, wherein said polymer also comprises anionic monomer and non-ionic monomer, and wherein said polymer shows the affinity to perfume base with one or more following character that the affinity of other perfume base of comparison is larger:

I) count molecular weight less than 200;

Ii) boiling point is less than 250 ℃;

Iii) ClogP is less than 3;

Iv) the Kovats index value is less than 1700,

Spices deposition and send testing scheme I and/or polymer beads affinity testing scheme II surveys as described;

B. by preformed polymer beads is mixed to form perfume polymeric particles with the spices that contains perfume base, described perfume base has one or more following character:

I) count molecular weight less than 200;

Ii) boiling point is less than 250 ℃;

Iii) ClogP is less than 3; With

Iv) the Kovats index value is less than 1700; With

C. contact described perfume polymeric particles with the personal nursing auxiliary element and form described personal care composition.

11. people and/or the skin of individual pets and/or the method for hair of nursing need nursing said method comprising the steps of:

A) contact skin and/or the hair of described individuality with perfume polymeric particles, described perfume polymeric particles comprises:

I) polymer and the spices that contains one or more perfume bases, described polymer is selected from anionic polymer, non-ionic polymers and their mixture, wherein said polymer also comprises anionic monomer and non-ionic monomer, and described perfume base has one or more following character:

A) count molecular weight less than 200;

B) boiling point is less than 250 ℃;

C) ClogP is less than 3;

D) the Kovats index value is less than 1700; With

B) flush away or not necessarily keep described personal care composition.

12. comprise the personal care composition of two or more different polymer beads and spices, described personal care composition comprises:

A) have the perfume base of one or more following character:

I) count molecular weight less than 200;

Ii) boiling point is less than 250 ℃;

Iii) ClogP is less than 3;

Iv) the Kovats index value is less than 1700; With

B) personal nursing auxiliary element;

The ARF that provides of the value of life test II wherein_LKIMore than or equal to ARF_HKIThe value 1.2 times,

Wherein said composition comprises the described polymer beads of at least 0.01% weight.