CN1706508A - Supersonic cure instrument for promoting healing of fracture and its supersonic wave generating method - Google Patents
Supersonic cure instrument for promoting healing of fracture and its supersonic wave generating method Download PDFInfo
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- CN1706508A CN1706508A CN 200510067149 CN200510067149A CN1706508A CN 1706508 A CN1706508 A CN 1706508A CN 200510067149 CN200510067149 CN 200510067149 CN 200510067149 A CN200510067149 A CN 200510067149A CN 1706508 A CN1706508 A CN 1706508A
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Abstract
The supersonic cure instrument for promoting healing of fracture. It includes instrument body and work head. The instrument body includes coded sequence wave generator for generating coded sequence modulated emitted wave, and power amplifier to amplify the modulated emitted wave; and the work head emits out the supersonic wave. The supersonic wave generating process includes: A. generating one HF sinusoidal wave with one HF sinusoidal wave generator and generating one LF sequence with one LF sequence generator; B. generating one sync signal with one sync signal source to synchronize the HF sinusoidal wave and the LF sequence and make them in phase; C. performing coding modulation with one multiplier to obtain continuous coded sequence modulated emitted wave. The coded sequence modulated emitted wave has low waveform peak, powerful penetrating capacity and no heat effect produced, and may be used in speeding the healing of fracture.
Description
Technical field
The present invention relates to field of medical, relate in particular to a kind of ultrasonic therapeutic apparatus that is used to promote union of fracture, and produce the method for special ultrasonic ripple.
Background technology
Ultrasonic energy can promote the healing of fracturing for known to the modern people, and union of fracture can be roughly three phases according to fracture seam tissue to hyperacoustic conductive performance: inflammatory reaction stage, cartilage crust stage, and callus stage.Up to the present, disclosed existing ultrasound wave promotes union of fracture instrument and method, all is according to directly stimulating the principle of osteogenesis tissue or cell to form; Because its action principle is directly to stimulate cartilage to form, so can only work to the healing of fracture at inflammatory reaction and cartilage crust stage; And because the ultrasound wave of the existing treatment union of fracture pulse modulation types that adopt as shown in Figure 1 more, promptly modulate high_frequency sine wave or impulse wave by pulse (low-frequency pulse) ripple in the qualification time limit shown in Fig. 1 a, form the pulsed modulating wave shown in Fig. 1 b, as transmitted pulse, the shortcoming that has transmitted waveform peak value height, penetration power difference, therefore treatment and promotion union of fracture need for a long time; And, referring to Einhorn TA article Clinically applied models of bone regeneration in tissueengineering research.Clinical Orthopaedics and Related Research367s:59-67 in 1998 as can be known, there is about 10% fracture case that delayed union or disunion may take place.Recently, through discovering calcitonin gene related protein is arranged all in each stage callus (Calcitonin gene related peptide, CGRP) the positive neurons fiber is grown into, and CGRP positive neurons fiber can be experienced ultrasonic stimulation, secretion CGRP, accelerating bone healing; Do not relate to the fracture recovering that reaches the promotion union of fracture with CGRP positive neurons fiber in the ultrasonic stimulation tissue and there is any report at present.
In addition, the ultrasound wave working head and the liquid couplant of human body contact need for the treatment of union of fracture at present are coupled, and the consumption of liquid couplant is improper can to influence the transmission of ultrasound wave to human body; And ultrasound wave working head and people's contact level for the treatment of union of fracture all are to adopt non-resilient non deformable material, the position of or less soft tissue uneven at body surface such as positions such as wrist, finger are difficult to reach the working head surface and combine closely with human body surface, thereby influence the transmission of ultrasound wave, and can't reach the purpose of effective treatment to human body.
Summary of the invention
Technical problem to be solved by this invention is: a kind of ultrasonic therapeutic apparatus that promotes union of fracture is provided, and this ultrasonic therapeutic apparatus can produce the special ultrasonic wave energy that waveform peak is low, penetration power is strong.
The problem that the present invention further will solve is that working head is improved, and makes between working head and the human body surface to mediate without fluid or viscid vehicle (couplant), also ultrasound wave can be transmitted to human body effectively.
Another technical problem to be solved by this invention is: a kind of method that produces the special ultrasonic ripple is provided.
The present invention solves the problems of the technologies described above the technical scheme that is adopted to be:
A kind of ultrasonic therapeutic apparatus that promotes union of fracture, comprise: ultrasonic therapeutic apparatus body and working head thereof, described ultrasonic therapeutic apparatus body comprises a coded sequence wave producer, and described coded sequence wave producer is used to produce successive coded sequence modulate emission ripple; Described successive coded sequence modulate emission ripple is launched by described working head after power amplifier amplifies.
Described first kind of ultrasonic therapeutic apparatus, wherein: described coded sequence wave producer comprises: one is used to produce the high frequency continuous impulse/high_frequency sine wave generator of high frequency continuous impulse/high_frequency sine wave; One is used to produce the low frequency sequence generator of low-frequency cycle coded sequence, and described low-frequency cycle coded sequence is used for the described high frequency continuous impulse/high_frequency sine wave of coded modulation; One is used to control described high frequency continuous impulse/high_frequency sine wave and the synchronous and synchronous synchronous generator of low-frequency cycle coded sequence; And a multiplier, two inputs of described multiplier link to each other with the outfan of low frequency sequence generator with described high frequency continuous impulse/high_frequency sine wave generator respectively, and generate and export described successive coded sequence modulate emission ripple.
Described second kind of ultrasonic therapeutic apparatus is characterized in that: described coded sequence wave producer comprises: one is used to produce the high frequency continuous impulse/high_frequency sine wave generator of high frequency continuous impulse/high_frequency sine wave; One is used to produce the low frequency sequence generator of low-frequency cycle coded sequence, and described low-frequency cycle coded sequence is used for the described high frequency continuous impulse/high_frequency sine wave of coded modulation; One frequency divider, described high frequency continuous impulse/high_frequency sine wave produces a synchronous signal behind described frequency divider frequency division, described synchronizing signal acts on described low frequency sequence generator, makes the synchronous and same phase of described low-frequency cycle coded sequence and described high frequency continuous impulse/high_frequency sine wave; And a multiplier, two inputs of described multiplier link to each other with the outfan of low frequency sequence generator with described high frequency continuous impulse/high_frequency sine wave generator respectively, and generate and export described successive coded sequence modulate emission ripple.
Described ultrasonic therapeutic apparatus, wherein: the frequency of described high frequency continuous impulse/high_frequency sine wave is 500KHz-3MHz advantageously; Advantageously a few Hz-several thousand KHz of the frequency of described low-frequency cycle coded sequence.
Described ultrasonic therapeutic apparatus, wherein: described coded sequence comprises m sequence or pseudo-random code sequence.
Above-mentioned ultrasonic therapeutic apparatus has been done some improvement on working head, comprising: on described working head and position that human body contacts, a couplings is set, described couplings adopts with the acoustic impedance identical materials of water and makes.
Described ultrasonic therapeutic apparatus, wherein: described couplings is a shell-like, is sleeved on the front end of described working head, and closely contacts with the outside of described working head.
Described ultrasonic therapeutic apparatus, wherein: described couplings adopts the rubber-like material to make, and makes described couplings produce strain under the effect of external force.
Described ultrasonic therapeutic apparatus, wherein: described couplings is made by Aquaflex ultrasoundgel pad.
Described ultrasonic therapeutic apparatus, wherein: described working head detachably is connected with the orthopaedics anchor clamps, and secure fit is integral; And adopt clamping between described working head and the orthopaedics anchor clamps.
The method that a kind of special ultrasonic ripple produces comprises the steps:
A, one high frequency continuous impulse/high_frequency sine wave generator produce one high frequency continuous impulse/high_frequency sine wave; The low-frequency cycle coded sequence that is used for the described high frequency continuous impulse/high_frequency sine wave of coded modulation with low frequency sequence generator generation one;
B, produce a synchronous signal with source of synchronising signal, described synchronizing signal makes described high frequency continuous impulse/high_frequency sine wave and described low-frequency cycle coded sequence is synchronous and same phase;
C, described synchronous and synchronous high frequency continuous impulse/high_frequency sine wave and low-frequency cycle coded sequence are carried out coded modulation in a multiplier, obtain successive coded sequence modulate emission ripple.
Beneficial effect of the present invention is: ultrasonic therapeutic apparatus of the present invention, because its ultrasound emission has adopted successive coded sequence modulating wave, therefore has the advantage that waveform peak is low, penetration power produces overheating effect by force and not, short skeletal growth factor is secreted at the osteanagenesis of fracture and sensory nerve end slightly had facilitation, and by promoting the short skeletal growth factor of nerve ending secretion to strengthen the effect that it promotes osteanagenesis; The coded sequence modulating wave can stimulate the CGRP positive neurons fiber secretion CGRP in each stage callus simultaneously, thereby can both the healing of fracture be played a driving role in each stage of union of fracture; Ultrasonic therapeutic apparatus energy accelerating bone healing therefore of the present invention shortens treatment time, reduces the incidence rate of delayed union or disunion.
Ultrasonic therapeutic apparatus of the present invention, owing on working head and position that human body contacts, be provided with a couplings, and described couplings adopts with the acoustic impedance identical materials of water and makes, making working head itself have the self coupling cooperation uses, therefore at interface that working head contacts with human body, do not need to use liquid couplant, enter human body and mediate ultrasound wave effectively.And, because couplings adopts the rubber-like material to make, strain can take place in couplings under external force that be fixed on the working head, therefore, even at the rough position of human body surface, also can working head and human body surface be reached seamlessly combine closely by exerting pressure, guarantee ultrasound wave effectively to the human body transmission, thereby reached the purpose of effective treatment.
Description of drawings
Fig. 1 a is that prior art is used for synthetic pulse, and Fig. 1 b is with the impulse modulation formula sine wave after the pulse modulation;
Fig. 2 is the block diagram of sonicator of the present invention
Fig. 3 is the block diagram of first kind of coded sequence wave producer of the present invention;
Fig. 4 is the block diagram of second kind of coded sequence wave producer of the present invention;
The sketch map of the coded sequence modulating wave that Fig. 5 a, b, c adopt for the present invention;
Fig. 6 is the working head structural representation of using with orthopaedics anchor clamps secure fit.
The specific embodiment
With embodiment the present invention is described in further detail with reference to the accompanying drawings below:
Ultrasonic therapeutic apparatus of the present invention is used to stimulate osteanagenesis, promotion and the accelerating bone healing of human body.As shown in Figure 2, ultrasonic therapeutic apparatus comprises a ultrasonic therapeutic apparatus body and a working head thereof, and the ultrasonic therapeutic apparatus body comprises a coded sequence wave producer and a power amplifier, and the coded sequence wave producer is used to produce successive coded sequence modulate emission ripple; This coded sequence modulate emission ripple is launched ultrasonic energy by working head after power amplifier amplifies, and acts on human body, stimulates the osteanagenesis of human body, makes union of fracture.The present invention and the most significant difference of prior art are, are the coded sequence modulating waves through the working head ultrasonic waves transmitted, and the coded sequence modulating wave is a continuous wave.The waveform that forms successive coded sequence modulating wave as shown in Figure 5, Fig. 5 a is the low-frequency cycle coded sequence that is used to encode, its frequency range is a few Hz-several thousand KHz; Fig. 5 b is depicted as the high frequency continuous impulse/high_frequency sine wave that is encoded, it can be the high_frequency sine wave shown in the solid line among Fig. 5 b, also can be the high frequency continuous impulse ripple shown in dotted line among Fig. 5 b, the frequency range of described high frequency continuous impulse or high_frequency sine wave be preferably at 500KHz-3MHz; Fig. 5 c then is by Fig. 5 a and the synthetic coded sequence modulating wave of Fig. 5 b, and synthetic coded sequence modulating wave is a continuous wave.Because successive coded sequence modulate emission ripple has the advantage that waveform peak is low, penetration power produces heat effect by force and not, therefore can act on the fracture deep effectively, short skeletal growth factor is secreted at the osteanagenesis of fracture and sensory nerve end slightly had facilitation, can stimulate simultaneously the CGRP positive neurons fiber secretion CGRP in each stage callus, thereby can both the healing of fracture be played a driving role in each stage of union of fracture.
The method that produces the coded sequence modulating wave is a lot, as: realizations such as available single-chip microcomputer, numeral, analog circuit or programming device.Coded sequence modulating wave of the present invention is produced by following method: A, produce one high frequency continuous impulse/high_frequency sine wave with one high frequency continuous impulse/high_frequency sine wave generator; And the low-frequency cycle coded sequence that is used for the described high frequency continuous impulse/high_frequency sine wave of coded modulation with low frequency sequence generator generation one, the low-frequency cycle coded sequence comprises as m sequence or pseudo-random code sequence, and its coding can be set, as 1001010......01, or 10101100......10; B, produce a synchronous signal, make the synchronous and same phase of high frequency continuous impulse/high_frequency sine wave and low-frequency cycle coded sequence with source of synchronising signal; C, synchronous and synchronous high frequency continuous impulse/high_frequency sine wave and low-frequency cycle coded sequence are carried out coded modulation in a multiplier, obtain successive coded sequence modulate emission ripple.According to said method, the present invention specifically adopts following two kinds of coded sequence wave producers:
First kind of coded sequence wave producer as shown in Figure 3 comprises: one is used to produce the high frequency continuous impulse/high_frequency sine wave generator of high frequency continuous impulse/high_frequency sine wave; One low frequency sequence generator; One generation also provides synchronizing signal, controls described high frequency continuous impulse/high_frequency sine wave and the synchronous and synchronous synchronous generator of low-frequency cycle code sequence train wave; And a multiplier, two inputs of described multiplier link to each other with the outfan of low frequency sequence generator with described high frequency continuous impulse/high_frequency sine wave generator respectively, generate and export described successive coded sequence modulate emission ripple.
Second kind of coded sequence wave producer as shown in Figure 4, comprise equally: one high frequency continuous impulse/high_frequency sine wave generator, a low frequency sequence generator and a multiplier, and the connected mode between the three and separately function identical with first kind of scheme all; Different is, synchronizing signal is to be produced through a frequency divider frequency division by high frequency continuous impulse/high_frequency sine wave generator, and act on described low frequency sequence generator, make the synchronous and same phase of described low-frequency cycle coded sequence and described high frequency continuous impulse/high_frequency sine wave.
Ultrasonic therapeutic apparatus of the present invention has also been done many improvement on working head.As shown in Figure 6, for solving the problem that prior art exists, technical scheme of the present invention is on described working head and position that human body contacts, fixedly installed a couplings 20, described couplings adopts with the acoustic impedance identical materials of water and makes, make working head itself have self coupling cooperation usefulness, in the process of treatment, the interface that working head contacts with human body surface does not need fluid/semifluid vehicle (couplant) mediation like this.The most simple and easy to do in practice method is that described couplings 20 is made shell-like, and the outer cover of being close to working head 10 is contained on the front end of described working head 10, and couplings 20 closely contacts with the outside of described working head 10; So design, couplings can often change, and both has been convenient to clean couplings to keep its cleaning, installs and uses and convenient.For at the rough position of human body surface, working head and human body surface are reached seamlessly combines closely, guarantee that ultrasound wave is effectively to the human body transmission, the material of making described couplings also should have elasticity, when working head is applied external force, couplings can produce corresponding strain with the curve of human body surface 40, combines closely thereby assurance working head and human body surface reach seamlessly.A kind of gel rubber Aquaflex ultrasound gel pad that couplings can adopt U.S. Parker Laboratory to produce makes, but is not limited only to this material.This material is resilient compound macromolecular polymer, and its acoustic impedance is identical with the acoustic impedance of water, even its acoustic impedance is constant under different-thickness or different pressures deformation state, can mediates ultrasound wave effectively and enter human body; And this material has bio-compatibility, human body is not damaged.
Because working head of the present invention itself has self coupling cooperation usefulness, need not liquid couplant.The liquid couplant of also just need not worrying flows into the problem in the clamping plate/plaster cylinder of orthopaedics anchor clamps, and working head can be used with the fracture anchor clamps (clamping plate/Gypsum Fibrosum) behind the fracture closed reduction.The present invention detachably is connected described working head 10 with orthopaedics anchor clamps 30, secure fit is integral; Can adopt the mode of clamping to be connected between working head and the orthopaedics anchor clamps, when carrying out the treatment of union of fracture, the working head of ultrasonic therapeutic apparatus is stuck in the corresponding site of fracture anchor clamps, working head is fixed into the fracture anchor clamps be one; And after finishing treatment, working head can be disassembled easily, satisfy the demand that treatment is used.
Adopt the ultrasonic therapeutic apparatus of promotion union of fracture of the present invention, through clinical experiment, its data show: 1, can shorten healing time effectively.Every day, the ultrasonic therapeutic apparatus with promotion union of fracture of the present invention stimulated fracture site 5-15 minute, and the union of fracture progress can accelerate 30%.2, can lower the nonunion risk.Every day, the ultrasonic therapeutic apparatus with promotion union of fracture of the present invention stimulated fracture site 5-15 minute, and the nonunion risk can lower 30-50%.
Should be understood that; a kind of method that is used to promote the ultrasonic therapeutic apparatus of union of fracture and produces the special ultrasonic ripple of the present invention; above-mentioned description at preferred embodiment is too concrete; can not therefore be interpreted as the restriction to scope of patent protection of the present invention, its scope of patent protection should be as the criterion with claims.
Claims (12)
1, a kind of ultrasonic therapeutic apparatus that promotes union of fracture, comprise: ultrasonic therapeutic apparatus body and working head thereof, it is characterized in that: described ultrasonic therapeutic apparatus body comprises a coded sequence wave producer, and described coded sequence wave producer is used to produce successive coded sequence modulating wave; Described successive coded sequence modulating wave is launched by described working head after power amplifier amplifies.
2, ultrasonic therapeutic apparatus according to claim 1 is characterized in that: described coded sequence wave producer comprises: one is used to produce the high frequency continuous impulse/high_frequency sine wave generator of high frequency continuous impulse/high_frequency sine wave; One is used to produce the low frequency sequence generator of low-frequency cycle coded sequence, and described low-frequency cycle coded sequence is used for the described high frequency continuous impulse/high_frequency sine wave of coded modulation; One is used to control described high frequency continuous impulse/high_frequency sine wave and the synchronous and synchronous synchronous generator of low-frequency cycle coded sequence; And a multiplier, two inputs of described multiplier link to each other with the outfan of low frequency sequence generator with described high frequency continuous impulse/high_frequency sine wave generator respectively, and generate and export described successive coded sequence modulate emission ripple.
3, ultrasonic therapeutic apparatus according to claim 1 is characterized in that: described coded sequence wave producer comprises: one is used to produce the high frequency continuous impulse/high_frequency sine wave generator of high frequency continuous impulse/high_frequency sine wave; One is used to produce the low frequency sequence generator of low-frequency cycle coded sequence, and described low-frequency cycle coded sequence is used for the described high frequency continuous impulse/high_frequency sine wave of coded modulation; One frequency divider, described high frequency continuous impulse/high_frequency sine wave produces a synchronous signal behind described frequency divider frequency division, described synchronizing signal acts on described low frequency sequence generator, makes the synchronous and same phase of described low-frequency cycle coded sequence and described high frequency continuous impulse/high_frequency sine wave; And a multiplier, two inputs of described multiplier link to each other with the outfan of low frequency sequence generator with described high frequency continuous impulse/high_frequency sine wave generator respectively, and generate and export described successive coded sequence modulate emission ripple.
4, ultrasonic therapeutic apparatus according to claim 2 is characterized in that: the frequency of described high frequency continuous impulse/high_frequency sine wave is 500KHz-3MHz advantageously; Advantageously a few Hz-several thousand KHz of the frequency of described low-frequency cycle coded sequence.
5, ultrasonic therapeutic apparatus according to claim 4 is characterized in that: described coded sequence comprises m sequence or pseudo-random code sequence.
6, according to any described ultrasonic therapeutic apparatus of claim of claim 1 to 5, it is characterized in that: on described working head and position that human body contact, a couplings is set, described couplings adopts and the acoustic impedance identical materials of water is made.
7, ultrasonic therapeutic apparatus according to claim 6 is characterized in that: described couplings is a shell-like, is sleeved on the front end of described working head, and closely contacts with the outside of described working head.
8, ultrasonic therapeutic apparatus according to claim 7 is characterized in that: described couplings adopts the rubber-like material to make, and makes described couplings produce strain under the effect of external force.
9, ultrasonic therapeutic apparatus according to claim 8 is characterized in that: described couplings is made by Aquaflex ultrasound gel pad.
10, ultrasonic therapeutic apparatus according to claim 7 is characterized in that: described working head detachably is connected with the orthopaedics anchor clamps, and secure fit is integral.
11, ultrasonic therapeutic apparatus according to claim 8 is characterized in that: be clamping between described working head and the orthopaedics anchor clamps.
12, a kind of method of special ultrasonic ripple generation comprises the steps:
A, produce one high frequency continuous impulse/high_frequency sine wave with one high frequency continuous impulse/high_frequency sine wave generator; The low-frequency cycle coded sequence that is used for the described high frequency continuous impulse/high_frequency sine wave of coded modulation with low frequency sequence generator generation one;
B, produce a synchronous signal with source of synchronising signal, described synchronizing signal makes described high frequency continuous impulse/high_frequency sine wave and described low-frequency cycle coded sequence is synchronous and same phase;
C, described synchronous and synchronous high frequency continuous impulse/high_frequency sine wave and low-frequency cycle coded sequence are carried out coded modulation in a multiplier, obtain successive coded sequence modulate emission ripple.
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| CNB2005100671492A CN100479888C (en) | 2005-04-19 | 2005-04-19 | Supersonic cure instrument for promoting healing of fracture and supersonic wave generating method thereof |
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| CN107648751A (en) * | 2017-08-15 | 2018-02-02 | 安隽医疗科技(南京)有限公司 | The information-based ultrasonic physiotherapy equipment of multifunctional intellectual |
| CN108452445A (en) * | 2015-12-30 | 2018-08-28 | 夏周阳 | One kind being cured device based on ultrasonic therapy bone |
| CN114377296A (en) * | 2022-01-19 | 2022-04-22 | 首都医科大学宣武医院 | Noninvasive deep brain electromagnetic coupling nerve regulation and control device |
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2005
- 2005-04-19 CN CNB2005100671492A patent/CN100479888C/en not_active Expired - Fee Related
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| CN108452445A (en) * | 2015-12-30 | 2018-08-28 | 夏周阳 | One kind being cured device based on ultrasonic therapy bone |
| CN108465166A (en) * | 2015-12-30 | 2018-08-31 | 夏周阳 | One kind being cured device based on ultrasonic therapy bone |
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| CN108465164B (en) * | 2015-12-30 | 2019-11-12 | 于许善 | One kind being cured device based on ultrasonic therapy bone |
| CN108452445B (en) * | 2015-12-30 | 2019-10-18 | 刘铭东 | One kind being cured device based on ultrasonic therapy bone |
| CN108543235B (en) * | 2015-12-30 | 2019-11-08 | 宁波新芝生物科技股份有限公司 | One kind being cured device based on ultrasonic therapy bone |
| CN108465166B (en) * | 2015-12-30 | 2019-11-08 | 宁波新芝生物科技股份有限公司 | One kind being cured device based on ultrasonic therapy bone |
| CN105832440A (en) * | 2016-05-11 | 2016-08-10 | 深圳市和拓网络科技有限公司 | Oral acoustic wave vibration cleaning device with pseudorandom amplitude adjustable |
| CN107648751A (en) * | 2017-08-15 | 2018-02-02 | 安隽医疗科技(南京)有限公司 | The information-based ultrasonic physiotherapy equipment of multifunctional intellectual |
| CN107648751B (en) * | 2017-08-15 | 2024-06-04 | 安隽医疗科技(南京)有限公司 | Multifunctional intelligent informationized ultrasonic physiotherapy instrument |
| CN114377296A (en) * | 2022-01-19 | 2022-04-22 | 首都医科大学宣武医院 | Noninvasive deep brain electromagnetic coupling nerve regulation and control device |
| CN114377296B (en) * | 2022-01-19 | 2024-09-13 | 首都医科大学宣武医院 | Noninvasive deep brain electromagnetic coupling nerve regulation and control device |
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| Publication number | Publication date |
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| CN100479888C (en) | 2009-04-22 |
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