CN1706485A - Blood-nourishing soft Chinese angelica capsule and its prepn process - Google Patents
Blood-nourishing soft Chinese angelica capsule and its prepn process Download PDFInfo
- Publication number
- CN1706485A CN1706485A CN 200510018273 CN200510018273A CN1706485A CN 1706485 A CN1706485 A CN 1706485A CN 200510018273 CN200510018273 CN 200510018273 CN 200510018273 A CN200510018273 A CN 200510018273A CN 1706485 A CN1706485 A CN 1706485A
- Authority
- CN
- China
- Prior art keywords
- capsule
- blood
- chinese angelica
- radix
- soft chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to soft Chinese medicine capsule, and is especially blood nourishing soft Chinese angelica capsule and its preparation process. The soft capsule includes two part of medicine liquid and covering. The medicine liquid includes medicine extractum and volatile oil extracted from angelica, white peony root, prepared rhizome of rehmannia, tuckahoe, licorice, Dangshen, astragalus root and Chuanxiong rhizome in certain weight proportion and vegetable oil in certain amount. The covering is made of material including gelatin, plasticizer and water. The present invention has the volatile well maintained, and has the functions similar to other angelica preparation, and the animal test shows that the present invention has obvious effect of preventing peripheral hemogram reduction caused by hydracetin and cyclophosphamide.
Description
Technical field
The present invention relates to Chinese medicinal soft capsule, especially a kind of blood-nourishing soft Chinese angelica capsule and preparation technology thereof.
Background technology
YANGXUE DANGGUI JING is recorded in second of ministry standard " Chinese traditional patent formulation preparation ".Bureau of Drugs Supervision of country is published as second batch of OTC kind.Originally be syrup, the clinical effectiveness reflection better.Product sells well for many years, but because of inconveniences such as syrup stores and transports, carries, uses, the easily greasy diaphragm of clothes for a long time, and easily corrupt rotten, particularly diabetics is unsuitable.
Usually the volatile oil component of principal agent Radix Angelicae Sinensis and Rhizoma Chuanxiong two flavors adopts steam distillation among technology the other side, and is long because of heated time, temperature is high, the average yield of volatile oil only 0.32%.Be unfavorable for embodying the pharmacological action of volatile oil.
At present, the practical application of Chinese medicine soft capsule is also few, have only minority kinds such as HUOXIANG ZHENGQI RUANJIAONANG, this is because have only traditional medicine volatile oil therapeutic effect to be had obviously contribution is just valuable to make soft capsule with it, and the present invention has given full play to the characteristic that soft capsule is easy to keep volatile oil.
In preparation blood-nourishing soft Chinese angelica capsule process, screen suitable capsule material batching: the proportioning between sizing material, plasticizer and the water, the stability of raising capsule material, making blood-nourishing soft Chinese angelica capsule have practical value becomes key.
Adopt suitable extraction process to obtain more oil yield.Thereby embody the pharmacological action of volatile oil more fully, help improving the curative effect of this preparation.
Summary of the invention
The object of the present invention is to provide a kind of blood-nourishing soft Chinese angelica capsule and preparation technology thereof.Compare with YANGXUE DANGGUI JING, blood-nourishing soft Chinese angelica capsule has improved curative effect.
Another object of the present invention is to screen suitable capsule material batching: the proportioning between sizing material, plasticizer and the water, the stability of raising capsule material makes blood-nourishing soft Chinese angelica capsule have good practical value.
Preferred medical material extractum: volatile oil: the weight proportion of vegetable oil, preferred suspending agent improves the stability of ferulic acid in the soft capsule.
Technical scheme of the present invention has following:
Blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises an amount of vegetable oil, and wherein: the consumption of extractum is the 133-425 gram in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is the 3-50 gram; The capsule material mainly is made up of sizing material, plasticizer and the water of weight proportion 1: 0.42-0.58: 0.8-1.2, and wherein sizing material comprises gelatin, any one in the arabic gum or mixture.
Blood-nourishing soft Chinese angelica capsule, its plasticizer are a kind of or mixture in glycerol, the sorbitol.
Plasticizer is the conventional knowledge that these those skilled in the art understand thoroughly as one of main component of soft capsule material, and plasticizer glycerol, sorbitol are documented in " pharmacy of Chinese materia medica "/Shanghai science tech publishing house/355th page " method for making of soft capsule " as the main component of soft capsule material.
The capsule material also comprises the antiseptic of capsule material weight 0.05-0.1%, the opacifier of capsule material weight 0.3-3%, an amount of Macrogol 4000 component, an amount of pigment.
Antiseptic is an ethylparaben, and opacifier is one or both in titanium dioxide, the ferrum oxide.Adopt opacifier to help the light stability of medical material extractum and volatile oil content.
Medical material extractum: volatile oil: the weight proportion of vegetable oil is 133-425: 3-50: 130-405.
Medical material extractum: volatile oil: the weight proportion of vegetable oil is 133-200: 3-30: 130-200.
The proportioning consumption of medicinal liquid and capsule material is 0.2-0.8: 0.8-0.2.
The optimal components ratio consumption of medicinal liquid and capsule material is 0.55: 0.45.
Medicinal liquid also comprises suspending agent, and suspending agent is a kind of in lecithin, Cera Flava, agar, the ethyl cellulose or several; The suspending agent consumption is the 1-5% of medicinal liquid weight.
Select the compound suspending agent mixture of lecithin 1%, Cera Flava 1%, agar 2%, ethyl cellulose 1% for use; Can obtain good suspendible effect, medical material extractum and volatile oil are not easy layering, and stability is better.Be embodied in the stability that improves ferulic acid in the soft capsule.
Also add the Macrogol 4000 of capsule material weight 1% in the capsule material.
The preparation technology of blood-nourishing soft Chinese angelica capsule is: (1) gets Radix Angelicae Sinensis, the Rhizoma Chuanxiong pulverize separately becomes coarse powder to extract with supercritical CO 2, and extracting pressure is 15-35Mpa, and temperature is 35-65 ℃, and the extraction time is 0.5-3.0 hour, gets its volatile oil, and medicinal residues are standby; (2) medicinal residues are pressed percolation, make solvent with 70% ethanol, flood to carry out percolation after 24 hours, and it is standby to collect percolate; All the other technical parameters can be specifically with reference to the " content of an appendix IO record of Chinese pharmacopoeia version in 2000; (3) after Poria added water boil, 80 ℃ of warm macerating secondaries filtered respectively, and merging filtrate is standby; (4) Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Codonopsis, the Radix Astragali, the Radix Glycyrrhizae five tastes such as (processed with honey) decoct with water secondary, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain the alcohol amount be 50%-80%, stir evenly, leave standstill, cold preservation 24 hours is filtered, when getting filtrate and above-mentioned reserve liquid and being evaporated to about 1.06 (60 ℃) of relative density, spray drying is ground into the dry powder that fine powder gets medical material extractum; (5) get above-mentioned volatile oil, the dry powder of medical material extractum and vegetable oil, suspending agent and excess material thereof feed intake by proportioning, a pelleting or a system behind the mistake colloid mill, drying, promptly.
Vegetable oil can be soybean oil, Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other are at the general vegetable oil in soft capsule field.
The invention has the advantages that: result of the test shows, blood-nourishing soft Chinese angelica capsule has the effect that mice peripheral blood hemogram that obvious antagonism acetylphenylhydrazine and cyclophosphamide coupling cause reduces.Acetylphenylhydrazine is caused that the blood-deficiency type mice has the effect that promotes that hemogram recovers.Losing blood property mice, rat there is the effect that promotes that erythrocyte generates and hemoglobin content increases.The mice pain that lumbar injection acetic acid is caused has the painful effect in tangible town.The effect of obvious reduction oxytocin induced mice writhing response number of times is arranged.Shrink tension, frequency to normal isolated uterine do not have obvious influence, and oxytocin is had antagonism, and it shrinks the effect of smooth muscle.Rabbit is had the obvious suppression effect in the body uterus by the uterine contraction blood-nourishing soft Chinese angelica capsule due to the oxytocin, and blood-nourishing soft Chinese angelica capsule has the effect that promotes immature female Mus developing womb.Its drug action intensity is smart close or more obvious with contrast health preserving with drugs Polygonum runcinatum var. sinense Hemsl..
Soft capsule usage of the present invention and consumption: oral, 3 times on the one, a 3-4 grain.Specification 0.45g-0.55g/ grain.Storage: sealing.
The blood-nourishing soft Chinese angelica capsule pharmacodynamic experiment is as follows:
Influence to the blood tonification effect of blood-deficiency type animal:
Test objective: observe the blood tonification effect of blood-nourishing soft Chinese angelica capsule to the blood-deficiency type animal.
Be subjected to the reagent thing: the blood-nourishing soft Chinese angelica capsule lot number: 20020404 specifications: 0.55g/ grain (1.22g (crude drug)/grain).The invention provides.Facing the time spent becomes 0.367g crude drug/ml with distilled water diluting.
Positive control medicine: YANGXUE DANGGUI JING lot number: 20020317 specifications: the 200ml/ bottle (the 0.367g crude drug/ml).Jiangxi Lignum cinnamomi camphorae pharmaceutical factory produces.
Laboratory animal: source, strain, the quality certification: mice, Kunming kind, inbred line closed colony, the moving word 021-9601 of doctor.Rat, SD kind, inbred line closed colony, the moving word 021-9601 of doctor.Body weight: mice 18～24g, rat 200～250g.Sex: male and female dual-purpose.
Test instrunment: double-tube biologic microscope, blood counting chamber, haemoglobinometer.
Experimental technique:
Blood tonification effect to losing blood property blood deficiency mice:
Get 50 of mices, male and female half and half are divided into 5 groups at random, every group 10, every group of each rathole socket of the eye venous plexus got the about 0.5ml of blood, gets blood respectively and surveys content of hemoglobin and erythrocyte number, after each Mus lost blood 24 hours, the eye socket venous plexus is got blood 50ul and is surveyed content of hemoglobin and erythrocyte number again, and each Mus gastric infusion according to dosage immediately, successive administration four days, once a day, survey content of hemoglobin and erythrocyte number in each Mus blood sampling in the 5th day, and statistical result, the results are shown in Table 1,2.
Table 1, blood-nourishing soft Chinese angelica capsule are to the blood tonification effect of losing blood property mice (X ± SD)
| Group | Dosage (g/kg) | Number of animals | Content of hemoglobin g/L | After the administration | Recruitment % | |
| Before losing blood | After losing blood | |||||
| Dosage group low dose group tanquedate group in the normal saline high dose group | ??5.0 ??2.5 ??1.67 ??5.0 | ??10 ??10 ??10 ??10 ??10 | ??148.0±16.6 ??155.8±19.5 ??151.1±15.4 ??149.6±22.1 ??156.0±15.5 | ?106±17★ ??109±21★ ??118±16★ ??111±17★ ??107±21★ | ??116±18* ??134±22** ??135±17** ??125±19* ??131±17** | ??9.4 ??22.9 ??14.4 ??12.6 ??21.3 |
With the preceding comparison of losing blood: ★ P＜0.01 with lose blood the back relatively:
*P＞0.05,
*P＜0.05
Table 2, blood-nourishing soft Chinese angelica capsule are to the blood tonification effect of losing blood property mice (X ± SD)
| Group | Dosage (g/kg) | Number of animals | Erythrocyte sum * 10 12/L | After the administration | Recruitment % | |
| Before losing blood | After losing blood | |||||
| Dosage group low dose group in the normal saline high dose group | ??5.0 ??2.5 ??1.67 | ??10 ??10 ??10 ??10 | ??7.9±1.1 ??8.6±1.1 ??7.9±1.2 ??8.3±1.5 | ?6.1±1.2★ ??6.2±1.1★ ??6.3±1.4★ ??6.5±1.2★ | ??6.9±1.2* ??7.7±1.0*** ??7.4±1.0* ??7.2±1.2* | ??11.3 ??24.2 ??17.5 ??10.8 |
| The tanquedate group | ??5.0 | ??10 | ??8.4±1.1 | ??6.3±1.0★ | ??7.6±1.0*** | ??20.6 |
With the preceding comparison of losing blood: ★ P＜0.01 with lose blood the back relatively:
*P＞0.05,
* *P＜0.01
Blood tonification effect to losing blood property blood deficiency rat:
Get 50 of rats, female, be divided into 5 groups at random, every group 10, every group of each eye socket venous plexus of Mus got blood 2.0ml, surveys hemoglobin content and erythrocyte sum respectively, after each Mus lost blood 24 hours, the eye socket venous plexus is got blood 50ul and is surveyed hemoglobin content and erythrocyte sum again, and each Mus gastric infusion according to dosage immediately, successive administration 5 days, once a day, hemoglobin content and erythrocyte sum are surveyed in each Mus blood sampling in 2 hours after the last administration, and statistical result, the results are shown in Table 3,4.
Table 3, blood-nourishing soft Chinese angelica capsule are to the blood tonification effect of losing blood property rat (X ± SD)
| Group | Dosage (g/kg) | Number of animals | Content of hemoglobin g/L | After the administration | Recruitment % | |
| Before losing blood | After losing blood | |||||
| Dosage group low dose group tanquedate group in the normal saline high dose group | ??3.5 ??1.75 ??1.17 ??3.5 | ??10 ??10 ??10 ??10 ??10 | ??157.1±18.1 ??163.4±22.6 ??157.7±17.2 ??150.9±18.0 ??151.7±18.9 | ?124±14★ ??123±16★ ??127±14★ ??119±15★ ??122±16★ | ??129±15* ??141±15** ??140±13** ??130±14* ??139±16** | ??13.2 ??24.8 ??19.7 ??19.2 ??24.1 |
With the preceding comparison of losing blood: ★ P＜0.01 with lose blood the back relatively:
*P＞0.05,
*P＜0.05
Table 4, blood-nourishing soft Chinese angelica capsule are to the blood tonification effect of losing blood property rat (X ± SD)
| Group | Dosage (g/kg) | Number of animals | Erythrocyte sum * 10 12/L | After the administration | Recruitment % | |
| Before losing blood | After losing blood | |||||
| Dosage group low dose group tanquedate group in the normal saline high dose group | ??3.5 ??1.75 ??1.17 ??3.5 | ??10 ??10 ??10 ??10 ??10 | ??9.8±0.8 ??9.6±1.1 ??10.2±1.8 ??10.4±1.8 ??10.1±1.8 | ?6.7±1.1★ ??6.7±1.3★ ??7.1±1.2★ ??7.4±1.1★ ??6.8±1.2★ | ??7.4±1.0* ??8.3±0.8*** ??8.4±1.3** ??8.4±1.1* ??8.3±1.0*** | ??10.4 ??23.9 ??18.3 ??13.5 ??22.1 |
With the preceding comparison of losing blood: ★ P＜0.01 with lose blood the back relatively:
*P＞0.05,
*P＜0.05,
* *P＜0.01
Result of the test shows, blood-nourishing soft Chinese angelica capsule has that mice peripheral blood hemogram that obvious antagonism acetylphenylhydrazine and cyclophosphamide coupling cause reduces and the effect of bone marrow micronucleus cell minimizing.The blood-deficiency type mice that acetylphenylhydrazine is caused has the effect that promotes that hemogram recovers.Losing blood property blood-deficiency type mice, rat there is the effect that promotes that erythrocyte generates and hemoglobin content increases.
The blood-nourishing soft Chinese angelica capsule of Isodose contrast tanquedate group, content of hemoglobin recruitment, erythrocyte sum recruitment are all stronger.
The analgesic activity of mice (writhing method due to the acetic acid):
Get 60 of healthy mices, male and female half and half are divided into 6 groups at random, and 10 every group, each group difference is gastric infusion according to dosage.Successive administration 4 days, once a day, after the last administration 30 minutes, with each group Mus respectively lumbar injection 0.5% acetum 0.2ml/ only left standstill 3 minutes, observe and respectively organize mice in 10 minutes and the writhing response number of times occurs, and calculate each medicine percentage rate that eases pain.The results are shown in Table 5.
Table 5, to the influence of writhing response due to the mice acetic acid (X ± SD)
| Group | Number of animals | Dosage g/kg | Turn round the body number of times | Analgesia rate % |
| Dosage group low dose group aspirin tanquedate group in the normal saline high dose group | ??10 ??10 ??10 ??10 ??10 ??10 | ??5.0 ??2.5 ??1.67 ??0.2 ??5.0 | ??56.8±17.4 ??35.6±18.9** ??41.5±15.1** ??49.4±16.1* ??21.9±8.6**** ??37.6±16.3** | ??36.9 ??26.6 ??12.4 ??69.5 ??33.3 |
Compare with the normal saline group: * P＞0.05, * * P＜0.05, * * * * P＜0.001
The blood-nourishing soft Chinese angelica capsule contrast tanquedate group of Isodose, the analgesia rate is stronger.
Influence to the mice swimming time:
Get 50 of normal health mices, be divided into 5 groups at random by sex, every group 10, male and female half and half, each group gives blood-nourishing soft Chinese angelica capsule (the administration volume is the 0.3ml/20g body weight), YANGXUE DANGGUI JING by dosage in the table respectively and with the normal saline of volume, successive administration 7 days, once a day, after the last administration 1 hour, to respectively put into depth of water 20cm respectively by the mice of body weight afterbody heavy burden 10%, water temperature remains in 20 ℃ the constant water bath box, and record is from time that mice entry to mouse head submerged can not emerge for 10 seconds.Be the swimming time of every Mus, and relatively carry out statistical procedures, survey its significance with matched group.Each organizes result of the test table 6.
Table 6, blood-nourishing soft Chinese angelica capsule are to the influence of mice swimming time (X ± SD)
| Group | Number of animals | Dosage (g/kg) | Mice swimming time (min) |
| Dosage group high dose group tanquedate group in the normal saline group low dose group | ??10 ??10 ??10 ??10 ??10 | ??1.67 ??2.5 ??5.0 ??5.0 | ??11.25±2.91 ??15.41±6.75* ??16.74±6.19** ??28.56±13.23**** ??23.52±7.64**** |
Compare with the normal saline group:
*P＞0.05,
*P＜0.05,
* * *P＜0.001
Influence to the effect of mice normal pressure resistant anoxia:
Get 80 of normal health mices, be divided into 5 groups at random by sex, every group 16, male and female half and half, the 2nd, 3, press 1.67g crude drug/kg for 4 groups, 2.5g crude drug/kg, 5.0g crude drug/kg. (the administration volume is the 0.3ml/20g body weight) gives the blood-nourishing soft Chinese angelica capsule diluent, the 3rd group gives the YANGXUE DANGGUI JING positive control drug by 5.0g crude drug/kg., the 1st group gives normal saline by the 0.3ml/20g body weight, successive administration 10 days, once a day, after the last administration 2 hours, each group Mus is put into the 300ml wide mouthed bottle (every bottle of Mus) that fills the 15g sodica calx respectively, tight with vaseline applicating bottle flap, timing at once is an index with the respiratory arrest, observe mice because of the dead time of anoxia, time-to-live after writing down it and going into bottle, relatively carry out mathematical statistics with the normal saline group, survey its significance.Each organizes result of the test table 7.
Table 7 blood-nourishing soft Chinese angelica capsule is to the influence of mice normal pressure resisting oxygen lack (X ± SD)
| Group | Number of animals | Dosage (g/kg) | The mice time-to-live (min) |
| Dosage group high dose group tanquedate group in the normal saline group low dose group | ??10 ??10 ??10 ??10 ??10 | ??1.67 ??2.5 ??5.0 ??5.0 | ??13.66±0.91 ??14.42±1.43* ??14.42±1.43* ??15.55±2.04** ??15.45±1.89** |
Compare with the normal saline group:
*P＞0.05,
*P＜0.05
Result of the test shows that blood-nourishing soft Chinese angelica capsule has the effect that prolongation mice swimming time strengthens its tolerance, and the trend that prolongs mice life span under the normobaric hypoxia condition is arranged.Demonstrate blood-nourishing soft Chinese angelica capsule and have the effect that comparatively significantly strengthens the mouse anti stress ability.
The blood-nourishing soft Chinese angelica capsule contrast tanquedate group of Isodose, it is longer to prolong the mice swimming time.
The specific embodiment
Embodiment 1
A kind of blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises vegetable oil, and wherein: the consumption of extractum is the 133-425 gram in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is the 3-50 gram, and vegetable oil is an amount of; The capsule material mainly is made up of sizing material, plasticizer and the water of weight proportion 1: 0.42-0.58: 0.8-1.2, and wherein sizing material is a gelatin.The vegetable oil consumption is the 130-405 gram.Plasticizer is a glycerol.The suspending agent consumption is the 1-5% of medicinal liquid.Proportioning consumption by medicinal liquid and capsule material is 0.2-0.8: the 0.8-0.2 pill.Vegetable oil can adopt the modal soybean oil in soft capsule field, also can replace with Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other at the general vegetable oil in soft capsule field, but does not all influence stability.
The preparation technology of blood-nourishing soft Chinese angelica capsule is: (1) gets Radix Angelicae Sinensis, the Rhizoma Chuanxiong pulverize separately becomes coarse powder to extract with supercritical CO 2, and extracting pressure is 15-35Mpa, and temperature is 35-65 ℃, and the extraction time is 0.5-3.0 hour, gets its volatile oil, and medicinal residues are standby; (2) medicinal residues are pressed percolation, make solvent with 70% ethanol, flood to carry out percolation after 24 hours, and it is standby to collect percolate; All the other technical parameters can be specifically with reference to the " content of an appendix IO record of Chinese pharmacopoeia version in 2000; (3) after Poria added water boil, 80 ℃ of warm macerating secondaries filtered respectively, and merging filtrate is standby; (4) Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Codonopsis, the Radix Astragali, the Radix Glycyrrhizae five tastes such as (processed with honey) decoct with water secondary, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain the alcohol amount be 50%-80%, stir evenly, leave standstill, cold preservation 24 hours is filtered, when getting filtrate and above-mentioned reserve liquid and being evaporated to about 1.06 (60 ℃) of relative density, spray drying is ground into the dry powder that fine powder gets medical material extractum; (5) get above-mentioned volatile oil, the dry powder of medical material extractum and vegetable oil, suspending agent and excess material thereof feed intake by proportioning, a pelleting or a system behind the mistake colloid mill, drying, promptly.
Embodiment 2
A kind of blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises vegetable oil, and wherein: the consumption of extractum is 133 grams in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is 50 grams, and vegetable oil is an amount of; The capsule material mainly is made up of 1: 0.42: 1.2 sizing material of weight proportion, plasticizer and water, and wherein sizing material is a gelatin.The vegetable oil consumption is 130 grams.Plasticizer is a glycerol.Suspending agent is a lecithin.The suspending agent consumption is 1% of a medicinal liquid.Proportioning consumption by medicinal liquid and capsule material is 0.45: 0.55 pill.Vegetable oil can adopt the modal soybean oil in soft capsule field, also can replace with Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other at the general vegetable oil in soft capsule field, but does not all influence stability.Keep sample and observe 0-6 month continuously, lamination does not all appear in medicinal liquid.
The preparation technology of blood-nourishing soft Chinese angelica capsule is: (1) gets Radix Angelicae Sinensis, the Rhizoma Chuanxiong pulverize separately becomes coarse powder to extract with supercritical CO 2, and extracting pressure is 15Mpa, and temperature is 35 ℃, and the extraction time is 3.0 hours, gets its volatile oil, and medicinal residues are standby; (2) medicinal residues are pressed percolation, make solvent with 70% ethanol, flood to carry out percolation after 24 hours, and it is standby to collect percolate; All the other technical parameters can be specifically with reference to the " content of an appendix IO record of Chinese pharmacopoeia version in 2000; (3) after Poria added water boil, 80 ℃ of warm macerating secondaries filtered respectively, and merging filtrate is standby; (4) Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Codonopsis, the Radix Astragali, the Radix Glycyrrhizae five tastes such as (processed with honey) decoct with water secondary, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 50%, stir evenly, leave standstill, cold preservation 24 hours is filtered, when getting filtrate and above-mentioned reserve liquid and being evaporated to about 1.06 (60 ℃) of relative density, spray drying is ground into the dry powder that fine powder gets medical material extractum; (5) get above-mentioned volatile oil, the dry powder of medical material extractum and vegetable oil, suspending agent and excess material thereof feed intake by proportioning, pelleting behind the mistake colloid mill, drying, promptly.
Embodiment 3
A kind of blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises vegetable oil, and wherein: the consumption of extractum is 425 grams in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is 3 grams, and vegetable oil is an amount of; The capsule material mainly is made up of 1: 0.58: 0.8 sizing material of weight proportion, plasticizer and water, and wherein sizing material is an arabic gum.The vegetable oil consumption is 405 grams.Plasticizer is a sorbitol.Suspending agent is a lecithin.The suspending agent consumption is 5% of a medicinal liquid.Proportioning consumption by medicinal liquid and capsule material is 0.6: 0.4 pill.Vegetable oil can adopt the modal soybean oil in soft capsule field, also can replace with Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other at the general vegetable oil in soft capsule field, but does not all influence stability.Keep sample and observe 0-6 month continuously, lamination does not all appear in medicinal liquid.
The preparation technology of blood-nourishing soft Chinese angelica capsule is: (1) gets Radix Angelicae Sinensis, the Rhizoma Chuanxiong pulverize separately becomes coarse powder to extract with supercritical CO 2, and extracting pressure is 35Mpa, and temperature is 65 ℃, and the extraction time is 0.5 hour, gets its volatile oil, and medicinal residues are standby; (2) medicinal residues are pressed percolation, make solvent with 70% ethanol, flood to carry out percolation after 24 hours, and it is standby to collect percolate; All the other technical parameters can be specifically with reference to the " content of an appendix IO record of Chinese pharmacopoeia version in 2000; (3) after Poria added water boil, 80 ℃ of warm macerating secondaries filtered respectively, and merging filtrate is standby; (4) Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Codonopsis, the Radix Astragali, the Radix Glycyrrhizae five tastes such as (processed with honey) decoct with water secondary, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 80%, stir evenly, leave standstill, cold preservation 24 hours is filtered, when getting filtrate and above-mentioned reserve liquid and being evaporated to about 1.06 (60 ℃) of relative density, spray drying is ground into the dry powder that fine powder gets medical material extractum; (5) get above-mentioned volatile oil, the dry powder of medical material extractum and vegetable oil, suspending agent and excess material thereof feed intake by proportioning, drip system behind the colloid mill excessively, drying, promptly.
Embodiment 4
Technical scheme of the present invention is screened the weight proportion of sizing material, plasticizer and water in the capsule material, and the consumption of plasticizer, water is too many, and the capsule material is soft partially, pressurized deliquescing easily, the moisture absorption; The consumption of plasticizer, water very little, the capsule material is hard partially, becomes fragile easily, influences the stability of soft capsule.
The weight proportion of table 8 sizing material, plasticizer, water is to the capsule material outward appearance of soft capsule and the influence of physical property
| Project | 10 parts in gelatin, 6.5 parts of glycerol, 14 parts in water | 10 parts of arabic gums, 3.5 parts of sorbitol, 3.0 parts of glycerol, 14 parts in water | 5 parts of 5 parts of arabic gums of gelatin, 6.5 parts of sorbitol, 14 parts in water | 10 parts in gelatin, 5.5 parts of glycerol, 9 parts in water | 10 parts of arabic gums, 5.5 parts of sorbitol, 8 parts in water |
| Capsule material outward appearance and physical property | Soft, the easy moisture absorption, easily torsional deformation | Soft, the easy moisture absorption, easily torsional deformation | Soft, the easy moisture absorption, easily torsional deformation | Neither too hard, nor too soft, indeformable | Neither too hard, nor too soft, indeformable |
| Project | 10 parts in gelatin, 4.0 parts of glycerol, 6 parts in water | 10 parts of arabic gums, 1.5 parts of sorbitol, 2.0 parts of glycerol, 7 parts in water | 5 parts of 5 parts of arabic gums of gelatin, 3.7 parts of sorbitol, 7 parts in water | 10 parts in gelatin, 5.5 parts of glycerol, 9 parts in water | 10 parts of arabic gums, 5.5 parts of sorbitol, 8 parts in water |
| Capsule material outward appearance and physical property, liquid medicine stability | Firmly, cracking after three months, lamination appears in medicinal liquid | Firmly, cracking after three months, lamination does not appear in medicinal liquid | Firmly, cracking after four months, lamination appears in medicinal liquid | Neither too hard, nor too soft, six months indeformable, do not ftracture, lamination does not appear in medicinal liquid | Neither too hard, nor too soft, six months indeformable, do not ftracture, lamination does not appear in medicinal liquid |
The result shows: the kind of sizing material, plasticizer is very little to stability influence, but the weight proportion of sizing material, plasticizer, water is bigger to stability influence.Therefore only need to limit the weight proportion of sizing material, plasticizer, water in the main technical scheme, and do not need to limit the kind of sizing material, plasticizer.
Embodiment 5
A kind of blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises vegetable oil, and wherein: the consumption of extractum is 265 grams in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is 45 grams, and vegetable oil is an amount of; The capsule material mainly is made up of 1: 0.48: 0.95 sizing material of weight proportion, plasticizer and water, and wherein sizing material is a gelatin: 1: 2 mixture of arabic gum.The vegetable oil consumption is 380 grams.Plasticizer is 1: 1 a mixture of glycerol, sorbitol.Suspending agent is the mixture of lecithin 1%, Cera Flava 2%, agar 2%.The capsule material also adds 2% Macrogol 4000.Proportioning consumption by medicinal liquid and capsule material is 0.4: 0.6 pill.Vegetable oil can adopt the modal soybean oil in soft capsule field, also can replace with Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other at the general vegetable oil in soft capsule field, but does not all influence stability.Keep sample and observe 0-6 month continuously, lamination does not all appear in medicinal liquid.
All the other are with embodiment 2.
Embodiment 6
Blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises vegetable oil, and wherein: the consumption of extractum is 155 grams in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is 8 grams, and vegetable oil is an amount of; The capsule material mainly is made up of 1: 0.5: 1.1 sizing material of weight proportion, plasticizer and water, and wherein sizing material is a gelatin.The vegetable oil consumption is 175 grams.Plasticizer is 1: 2 a mixture of glycerol, sorbitol.Suspending agent is the mixture of lecithin 1%, Cera Flava 1%, agar 2%, ethyl cellulose 1%; Also add the Macrogol 4000 of capsule material weight 1% in the capsule material.Proportioning consumption by medicinal liquid and capsule material is 0.5: 0.5 pill.Vegetable oil can adopt the modal soybean oil in soft capsule field, also can replace with Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other at the general vegetable oil in soft capsule field, but does not all influence stability.
All the other are with embodiment 3.
Embodiment 7
A kind of blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises vegetable oil, and wherein: the consumption of extractum is 220 grams in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is 25 grams, and vegetable oil is an amount of; The capsule material mainly is made up of 1: 0.58: 0.8 sizing material of weight proportion, plasticizer and water, and wherein sizing material is an arabic gum.The vegetable oil consumption is 300 grams.Plasticizer is a sorbitol.Suspending agent is the mixture of lecithin 1%, Cera Flava 1%, agar 2%, ethyl cellulose 1%; Also add the Macrogol 4000 of capsule material weight 1% in the capsule material.Proportioning consumption by medicinal liquid and capsule material is 0.8: 0.2 pill.Vegetable oil can adopt the modal soybean oil in soft capsule field, also can replace with Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other at the general vegetable oil in soft capsule field, but does not all influence stability.
All the other are with embodiment 2.
Embodiment 8
Blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises vegetable oil, and wherein: the consumption of extractum is 190 grams in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is 24 grams, and vegetable oil is an amount of; The capsule material mainly is made up of 1: 0.5: 1.0 sizing material of weight proportion, plasticizer and water, and wherein sizing material is a gelatin.The vegetable oil consumption is 380 grams.Plasticizer is 1: 2 a mixture of glycerol, sorbitol.Suspending agent is the mixture of lecithin 2%, Cera Flava 1%.The capsule material also adds 1% Macrogol 4000.Also add antiseptic ethylparaben 0.8%.Opacifier is in titanium dioxide 1%, the ferrum oxide 1%.Proportioning consumption by medicinal liquid and capsule material is 0.2: 0.8 pill.Vegetable oil can adopt the modal soybean oil in soft capsule field, also can replace with Oleum Arachidis hypogaeae semen, Semen Maydis oil, olive oil, Oleum Camelliae, Oleum Helianthi, Oleum Sesami and other at the general vegetable oil in soft capsule field, but does not all influence stability.
All the other are with embodiment 3.
Embodiment 9
A kind of blood-nourishing soft Chinese angelica capsule, suspending agent are the mixture of lecithin 2%, Cera Flava 3%.And add 1% Macrogol 4000.Also add antiseptic ethylparaben 0.05%.Opacifier is a titanium dioxide 0.3%.Adopt steam distillation to extract volatile oil, steam distillation specifically is documented in " appendix XD of Chinese pharmacopoeia version in 2000.All the other are with embodiment 2.
Embodiment 10
A kind of blood-nourishing soft Chinese angelica capsule, plasticizer are 3: 1 mixture of glycerol, sorbitol.Suspending agent is the mixture of lecithin 0.5%, ethyl cellulose 0.5%.Also add antiseptic ethylparaben 0.1%.Opacifier is a ferrum oxide 3%.Adopt steam distillation to extract volatile oil, steam distillation specifically is documented in " appendix XD of Chinese pharmacopoeia version in 2000.All the other are with embodiment 3.
Embodiment 11
A kind of blood-nourishing soft Chinese angelica capsule also adds antiseptic ethylparaben 0.1%.Opacifier is a ferrum oxide 3%.Adopt steam distillation to extract volatile oil, steam distillation specifically is documented in " Chinese pharmacopoeia
Appendix XD of version in 2000, relatively two parts are extracted yield, the results are shown in Table 9.
Table 9, Radix Angelicae Sinensis, the supercritical extraction of Rhizoma Chuanxiong and steam distillation be comparison sheet as a result
| Method | Medical material | Sampling amount (g) | Get oil mass (ml) | Oil yield (ml/100g) |
| Supercritical extraction | Radix Angelicae Sinensis+szechuan lovage rhizome-angelica+szechuan lovage rhizome-angelica+Rhizoma Chuanxiong | ??907.5 ??907.5 ??907.5 | ??14.0 ??13.7 ??14.3 | ??1.54 ??1.51 ??1.57 |
| Steam distillation | Radix Angelicae Sinensis+szechuan lovage rhizome-angelica+szechuan lovage rhizome-angelica+Rhizoma Chuanxiong | ??453.8 ??453.8 ??453.8 | ??1.54 ??1.41 ??1.60 | ??0.34 ??0.31 ??0.35 |
The above results shows, supercritical fluid (CO
2) the average oil yield of extraction is 1.54%, and steam distillation only is 0.33%, ratio between two is 4.7: 1, according to another bibliographical information supercritical fluid (CO
2) extraction volatile ingredient, can obtain the unavailable composition of conventional steam distillation, particularly can extract a series of alkanes, organic acid and esters thereof.Reason is that the extraction process temperature is low, and the airtight volatile ingredient that can preserve in a large number thermally labile and easy oxidation of system.So this preparation process adopts supercritical fluid (CO
2) extract.
All the other are with embodiment 6.
Embodiment 12
The selection of investigating suspending agent is to the influence of the stability of improving blood-nourishing soft Chinese angelica capsule:
All the other select prescription and the technology of embodiment 6.
With supercritical fluid (CO
2) extract Radix Angelicae Sinensis, the Rhizoma Chuanxiong medicinal residues of volatile oil, still contain a large amount of water soluble ingredients, the present invention investigates the stability of measuring blood-nourishing soft Chinese angelica capsule with one of effective ingredient ferulic acid as the variation of index components content, to select more rational suspending agent.
The chromatographic condition of content of ferulic acid assay method and system suitability test: with octadecylsilane chemically bonded silica is filler; Methanol-1% acetic acid water (32: 68) is mobile phase; The detection wavelength is 320nm.
(A1): suspending agent is the mixture of lecithin 1%, Cera Flava 1%, agar 1%, ethyl cellulose 1%.
(A2) suspending agent is a lecithin 4%.
(A3) suspending agent is a Cera Flava 4%.
(A4) suspending agent is an agar 4%.
(A5) suspending agent is an ethyl cellulose 4%.
(A6) suspending agent is lecithin 2%, oil with hydrogenated soybean 2%.
(A7) suspending agent is blank.
The The effects result of table 10 stability
| The project ferulaic acid content | (A1) suspending agent | (A2) suspending agent | (A3) suspending agent | (A4) suspending agent | (A5) suspending agent | (A6) suspending agent | (A7) suspending agent |
| Ferulaic acid content (first month) % | ??0.026 | ??0.024 | ??0.027 | ??0.023 | ??0.019 | ??0.020 | ??0.017 |
| Ferulaic acid content (three month) % | ??0.025 | ??0.022 | ??0.024 | ??0.021 | ??0.015 | ??0.017 | ??0.014 |
| Ferulaic acid content (six month) % | ??0.025 | ??0.020 | ??0.022 | ??0.017 | ??0.014 | ??0.016 | ??0.011 |
Obviously the selection of (A1) suspending agent helps the stable of blood-nourishing soft Chinese angelica capsule most, but other suspending agents also have certain contribution to the stable of blood-nourishing soft Chinese angelica capsule, belong to the acceptable scope.Do not add suspending agent and also can keep certain ferulaic acid content, but drug effect is influenced slightly.
Claims (9)
1, a kind of blood-nourishing soft Chinese angelica capsule is made of medicinal liquid and capsule material two large divisions, and medicinal liquid comprises the raw material by the following weight parts meter: Radix Angelicae Sinensis 880, the Radix Paeoniae Alba 55, Radix Rehmanniae Preparata 55, Poria 55, Radix Glycyrrhizae (processed with honey) 27.5, Radix Codonopsis 55, medical material extractum and volatile oil that the Radix Astragali 55, Rhizoma Chuanxiong 27.5 are made; Medicinal liquid also comprises an amount of vegetable oil, it is characterized in that: the consumption of extractum is the 133-425 gram in per 1000 blood-nourishing soft Chinese angelica capsules, and the consumption of volatile oil is the 3-50 gram; The capsule material mainly is made up of sizing material, plasticizer and the water of weight proportion 1: 0.42-0.58: 0.8-1.2, and wherein sizing material comprises gelatin, any one in the arabic gum or mixture.
2, blood-nourishing soft Chinese angelica capsule as claimed in claim 1 is characterized in that: plasticizer is a kind of or mixture in glycerol, the sorbitol.
3, blood-nourishing soft Chinese angelica capsule as claimed in claim 1 is characterized in that: the capsule material also comprises the antiseptic of capsule material weight 0.05-0.1%, the opacifier of capsule material weight 0.3-3%.
4, blood-nourishing soft Chinese angelica capsule as claimed in claim 3 is characterized in that: antiseptic is an ethylparaben, and opacifier is one or both in titanium dioxide, the ferrum oxide.
5, blood-nourishing soft Chinese angelica capsule as claimed in claim 1 is characterized in that: medical material extractum: volatile oil: the weight proportion of vegetable oil is 133-425: 3-50: 130-405.
6, blood-nourishing soft Chinese angelica capsule as claimed in claim 1 is characterized in that: the proportioning consumption of medicinal liquid and capsule material is 0.2-0.8: 0.8-0.2.
7, blood-nourishing soft Chinese angelica capsule as claimed in claim 1 is characterized in that: medicinal liquid also comprises suspending agent, and suspending agent is a kind of in lecithin, Cera Flava, agar, the ethyl cellulose or several; The suspending agent consumption is the 1-5% of medicinal liquid weight.
8, blood-nourishing soft Chinese angelica capsule as claimed in claim 7 is characterized in that: suspending agent is the mixture of lecithin 1%, Cera Flava 1%, agar 2%, ethyl cellulose 1%; Also add the Macrogol 4000 of capsule material weight 1% in the capsule material.
9, the preparation technology according to claim 1 or 3 described blood-nourishing soft Chinese angelica capsules is: (1) gets Radix Angelicae Sinensis, the Rhizoma Chuanxiong pulverize separately becomes coarse powder to extract with supercritical CO 2, extracting pressure is 15-35Mpa, and temperature is 35-65 ℃, and the extraction time is 0.5-3.0 hour, get its volatile oil, medicinal residues are standby; (2) medicinal residues are made solvent by percolation with 70% ethanol, flood to carry out percolation after 24 hours, and it is standby to collect percolate; (3) after Poria added water boil, 80 ℃ of warm macerating secondaries filtered respectively, and merging filtrate is standby; (4) Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Codonopsis, the Radix Astragali, the Radix Glycyrrhizae five tastes such as (processed with honey) decoct with water secondary, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain the alcohol amount be 50%-80%, stir evenly, leave standstill, cold preservation 24 hours is filtered, when getting filtrate and above-mentioned reserve liquid and being evaporated to about 1.06 (60 ℃) of relative density, spray drying is ground into the dry powder that fine powder gets medical material extractum; (5) get above-mentioned volatile oil, the dry powder of medical material extractum and vegetable oil, suspending agent and excess material thereof feed intake by proportioning, a pelleting or a system behind the mistake colloid mill, drying, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510018273A CN100593411C (en) | 2005-02-06 | 2005-02-06 | Blood-nourishing soft Chinese angelica capsule and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510018273A CN100593411C (en) | 2005-02-06 | 2005-02-06 | Blood-nourishing soft Chinese angelica capsule and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1706485A true CN1706485A (en) | 2005-12-14 |
| CN100593411C CN100593411C (en) | 2010-03-10 |
Family
ID=35580716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200510018273A Expired - Fee Related CN100593411C (en) | 2005-02-06 | 2005-02-06 | Blood-nourishing soft Chinese angelica capsule and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100593411C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984997A (en) * | 2010-10-11 | 2011-03-16 | 南京中医药大学 | Anti-tumor composition containing four-substance decoction extract and application thereof |
| CN101618116B (en) * | 2008-06-30 | 2012-11-28 | 浙江康恩贝制药股份有限公司 | Method for preparing blood-nourishing angelica capsules by using powder coatings |
| CN114668808A (en) * | 2022-03-31 | 2022-06-28 | 河南中医药大学 | Traditional Chinese medicine microecological preparation for reducing animal transportation stress hazard and preparation method thereof |
-
2005
- 2005-02-06 CN CN200510018273A patent/CN100593411C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618116B (en) * | 2008-06-30 | 2012-11-28 | 浙江康恩贝制药股份有限公司 | Method for preparing blood-nourishing angelica capsules by using powder coatings |
| CN101984997A (en) * | 2010-10-11 | 2011-03-16 | 南京中医药大学 | Anti-tumor composition containing four-substance decoction extract and application thereof |
| CN114668808A (en) * | 2022-03-31 | 2022-06-28 | 河南中医药大学 | Traditional Chinese medicine microecological preparation for reducing animal transportation stress hazard and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100593411C (en) | 2010-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1840166A (en) | Modern Chinese medicinal oral liquid of 'Wen Dan Tang' and preparation method thereof | |
| CN1233387C (en) | Chinese compound medicine for treating anhypnosis and its preparation metod | |
| CN1706485A (en) | Blood-nourishing soft Chinese angelica capsule and its prepn process | |
| CN1319576C (en) | Compound Chinese medicine with functions of nourishing vital energy, nourishing blood and tranquilizing and its production process | |
| CN1927331A (en) | Chinese medicine preparation for curing chronic heart failure | |
| CN1883557A (en) | Application of 'Guizhi Gancao Longgu Muli' preparation in preparation of medicine for preventing and treating depression | |
| CN1214811C (en) | Traditional Chinese medicine for treating neurosism, extracting process, formation process and use thereof | |
| CN1830469A (en) | Medicine for improving sleep quality and its preparation method | |
| CN1316960C (en) | Compound mactra clam drip pill and its preparation method | |
| CN100340271C (en) | Hypoglycemic medicine for treating diabetes and its prepn process | |
| CN1272047C (en) | Medicine for invigorating liver and kidney to treat dryness of large intestine and constipation | |
| CN1241586C (en) | Chinese medicine composition and preparing method thereof | |
| CN1278734C (en) | Pharmaceutical composition for stopping drug addiction and its preparing process | |
| CN1203891C (en) | Medicine for treating coronary heart disease and its preparation method | |
| CN1853697A (en) | Use of konjak and its extract in preparation of medicine for treating acute and chronic bronchitis | |
| CN1446554A (en) | Medicine for treating acute cholecystitis and chronic cholecystitis and its preparing method | |
| CN1824075A (en) | Medicinal composition for treating hemicrania and its application | |
| CN1931256A (en) | Chinese medicine capsule for eliminating drug addiction and its prepn process | |
| CN102309550A (en) | Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof | |
| CN1682980A (en) | Medicine for treating diabetes and its preparing method | |
| CN100337649C (en) | Medicine for treating rheumatic arthritis and its preparing method | |
| CN1853711A (en) | Xinmaikangzhong Chinese medicinal composition and preparation thereof | |
| CN1891277A (en) | Medicinal composition for treating coronary disease, and its preparing method and use | |
| CN1275591C (en) | Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method | |
| CN1493356A (en) | Medicine for treating gastrointestinal tract disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: CHINA RESOURCES SANJIU (NANCHANG) PHARMACEUTICAL C Free format text: FORMER NAME: JIANGXI SANJIU PHARMACEUTICAL INDUSTRY CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 330012, Dongsheng Road, Chang Dong Industrial Zone, Jiangxi, Nanchang, 398 Patentee after: Huarun 39 (Nanchang) Pharmaceutical Co., Ltd. Address before: 330043 No. 411, Qingyun Road, Nanchang, Jiangxi Patentee before: Jiangxi Sanjiu Pharmaceutical Co., Ltd. |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100310 Termination date: 20130206 |