CN1701801A - Health caring product for preventing and treating hyperkinetic syndrome of children and teenagers - Google Patents
Health caring product for preventing and treating hyperkinetic syndrome of children and teenagers Download PDFInfo
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- CN1701801A CN1701801A CN 200410023236 CN200410023236A CN1701801A CN 1701801 A CN1701801 A CN 1701801A CN 200410023236 CN200410023236 CN 200410023236 CN 200410023236 A CN200410023236 A CN 200410023236A CN 1701801 A CN1701801 A CN 1701801A
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- rhizoma gastrodiae
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Abstract
The invention relates to a health caring product for preventing and treating hyperkinetic syndrome of children and teenagers, wherein the preparation comprises extracting active components from natural plants including gastrodia tuber, wampee, Stizolobium capitatum and Chinese ephedra, then proportioning reasonably. The health product can regulate human body's immunity.
Description
Technical field
The present invention relates to use the health product of natural plants active substance as effective ingredient.
Background technology
Child, teenager hyperkinetic syndrome are to be accompanied by extensively popularizing and a kind of creep disease of children and youth initiation such as too much again absorption sugar and high-fat food in diet of modern society's informationization, digitized high speed development and electronic product (as television set, computer, game machine, phone, music etc.).Medical research is thought, lack a kind of dopamine and the oxidasic composition of amfetamine in the children and youth body of trouble hyperkinetic syndrome, thereby cause child, teenager cerebral cortex superexcitation, learn absent minded, study, do things and to be absorbed in, study is diligent and do very well, and language, thinking logic are unclear, reading, poor, forgetful, the poor memory of study understandability, careless, short-tempered, fidgety, happiness is moving and equilibrant difference etc. in moving.And this is often easily ignored by household, teacher and doctor, thinks that just child is naughty.Yet arrived the mid-term of hyperkinetic syndrome, attention is difficult to concentrate, and learns absent-mindedly, can not be absorbed in thinking, and pressure has in study increased the weight of tendency of being weary of studying, playing truant etc. again.Have a strong impact on teen-age knowledge learning and skill master.In the late period of hyperkinetic syndrome, teenager begins to be weary of study.Moreover the pressure of society, family and employment etc. makes the crowd who suffers from hyperkinetic syndrome very easily turn to schizophrenia, melancholia etc., even may endanger society.This shows that child, teenager hyperkinetic syndrome have become harm national personnel training and child, the able-bodied a kind of very important disease of teenager.
Summary of the invention
The technical problem to be solved in the present invention is, defective at prior art, the cause of disease according to child, teenager hyperkinetic syndrome, propose to improve after a kind of the taking the health product of child, teenager hyperkinetic syndrome symptom, on purpose, the material composition that is lacked in the additional child of targeting, the teenager hyperkinetic syndrome disease, thereby realize relying on natural materials to remedy self deficiency, recover the function of human body balance and reach healthy purpose.
Technical solution of the present invention is, the health product of a kind of prevention and treatment children and youth hyperkinetic syndrome, and its composition is:
Rhizoma Gastrodiae extract 10-15 gram,
Cat bean extract 2-3 gram,
Fructus clausenae lansii extract 8-12 gram,
Herba Ephedrae extract 3-5 gram.
Each component uniform mixing with said ratio adds conventional adjuvant, promptly can be made into plurality kinds of health care, nutrition dosage forms such as oral liquid, capsule, electuary, tablet, unguentum.
Among the present invention, the extract of each component is respectively the material that adopts following raw material and technology to obtain.
(1) Rhizoma Gastrodiae extract: get Rhizoma Gastrodiae, pulverize, cross 80 mesh sieves, extract (time 2-3 hour) with methanol or 80% ethanol heating (boiling), filter, so repeat to extract 4 times. merge methanol or ethanol liquid, reclaim under reduced pressure methanol or ethanol liquid get Rhizoma Gastrodiae extract Rhizoma Gastrodiae extract powder, with gastrodine is that standard substance are surveyed its total content, the Rhizoma Gastrodiae general glycoside is the Rhizoma Gastrodiae extract that the present invention uses at 80-95%
(2) cat bean extract: get the cat bean, pulverize, cross 80 mesh sieves, with methanol or 80% acetone, heating and refluxing extraction (time 2-3 hour) is filtered methanol or 80% acetone solution, so repeats 4 times, merge methanol or acetone solution, reclaim under reduced pressure methanol or acetone are handled with polyamide resin then, collect the eluent of PH4-5, eluent is removed in decompression, obtaining cat bean extract extract powder, is that standard substance are surveyed its content with dopamine, and the DOPA total alkali is at 70-85%, be the cat bean extract that the present invention uses
(3) Fructus clausenae lansii extract: get Fructus clausenae lansii, pulverize, cross 40 mesh sieves, with 85% ethanol heating and refluxing extraction (time 2-3 hour).Filter ethanol liquid, so repeat 3 times, merge alcoholic extract; reclaim under reduced pressure ethanol; handle with polyamide resin then, collect 90% ethanol eluent, reclaim under reduced pressure ethanol; the decolouring of reuse grain active carbon; obtaining the Fructus clausenae lansii extract extract powder, is that standard substance are surveyed its content with clausenamide, and the clausenamide total alkali is at 60-75%; be the Fructus clausenae lansii extract that the present invention uses
(4) Herba Ephedrae extract: get the Herba Ephedrae herb, pulverize, cross 40 mesh sieves, extract with distilled water heating (boiling), time 2-3 hour, filter extracting solution, the furrow filter causes liquid night, so repeats merge extractive liquid, 2 times, the decompression extracting solution is to volume 1/3ml, then with toluene extraction 3 times, combining extraction liquid, reclaim under reduced pressure toluene. obtain the Herba Ephedrae extract extract powder, with ephedrine is that standard substance are surveyed its content, and the Herba Ephedrae total alkali is the Herba Ephedrae extract that the present invention uses at 40-55%.
The total amount of described each extract can be:
(1) Rhizoma Gastrodiae extract is that standard substance are surveyed with the gastrodine, contains Rhizoma Gastrodiae general glycoside 80-95%,
(2) cat bean extract is that standard substance are surveyed with the dopamine, contains DOPA total alkali 70-85%,
(3) Fructus clausenae lansii extract is that standard substance are surveyed with the clausenamide, contains clausenamide total alkali 60-75%.
(4) Herba Ephedrae extract is that standard substance are surveyed with the ephedrine, contains Herba Ephedrae total alkali 40-55%.
Evidence of the present invention, the effective ingredient of these natural plants and known activity composition, through reasonable combination, be configured to the stronger health product that prevent and treat the children and youth hyperkinetic syndrome of a kind of selectivity, it concentrates the medicine side effect little, the Western medicine instant effect, the obvious results advantage, enter the immunologic function of regulating human body behind the human body, activate dopamine and oxidasic secretion of amfetamine and metabolism, thereby realize prevention and treatment child, the effect of teenager hyperkinetic syndrome, and raising child, teen-age memory and learning effect, this strain is used the total composition of natural activity, thereby has the little characteristics of toxic and side effects.
The active component Rhizoma Gastrodiae general glycoside of the Rhizoma Gastrodiae that uses among the present invention (Rhizoma gostrodiae) extract all proves in again in modern pharmacology, pharmacodynamics, clinical and real life fortune, the effect of calmness is arranged, calming the nerves, the effect that improves child, teenager memory is arranged, overwrought cerebral cortex is had inhibitory action.In the present invention child, teenager hyperkinetic syndrome there is significant coordinative role.
The active component dopamine total alkali of the cat bean that uses among the present invention (Levodopa extract) extract is to lack in child, the teenager hyperkinetic syndrome patient body or the composition of a kind of brain cell demand of hyposecretion. it has adjusting function to the emerging maincenter that is equipped with of mesencephalic centre, and the over-drastic emerging state that is equipped with is suppressed.
The active component clausenamide total alkali of the Fructus clausenae lansii that uses among the present invention (Clausena lansium) extract. be modern pharmacology, pharmacodynamics and clinical confirmation and the human relevant chemical constituent of memory, to promoting that improving human memory, faculty of understanding has significant effect, also be a kind of useful chemical constituent that lacks in child, the teenager hyperkinetic syndrome patient body.
The active component Herba Ephedrae total alkaloids of the Herba Ephedrae of using among the present invention (Herba ephedrae) extract is the important substance that a class is replenished amphetamine, it can swash the in vivo active function of amfetamine enzyme, replenish nutrient can for cortical cell rugged in the brain excitement and blood, thereby being overexcited of regulation and control brain, promote concentration power, the attention of human thinking, can make the excited cortex state that restores balance, make brain function recover normal sleep, the brain cell of memory is increased, on prevention and treatment child, teenager hyperkinetic syndrome, play an important role.
The present invention scientifically extracts above-mentioned active skull cap components, reasonably be combined into a kind of health product that easily absorbed, digest then by child, teenager hyperkinetic syndrome patient, allow these effective active component in child, teenager hyperkinetic syndrome patient body, pass through to adjust immunity of organisms, activate dopamine and oxidasic secretion of amfetamine and metabolism, thereby improve hyperkinetic syndrome patient's symptom.Owing to various active component such as the above-mentioned natural plants that derives among the present invention, the two-way function of self regulating and control is arranged in vivo, thereby toxic and side effects is little, be effective preparation of prevention and treatment child, teenager hyperkinetic syndrome.
The specific embodiment
Embodiment 1: the producing of each extract components.
1, get Rhizoma Gastrodiae (Rhizoma gostrodiae) rhizome dry product (wild or cultivation) 100g, pulverized 80 mesh sieves, put into extractor and add methanol (analytical pure) or 80% ethanol 400ml, in water-bath, be heated to boiling, reflux, extract, (time 2-3 hour), buchner funnel filters methanol or ethanol liquid, so mode repeats 4 times, and behind the merge extractive liquid,, methanol or ethanol are reclaimed in decompression (2.5 kPas), with extract with water dissolution after, cross D201 or D101 type resin and handle (extractum with weight resin than 1: 8), the first deionized water eluting of using, use 90% methanol or ethanol eluting then, collect eluent, eluent, the Rhizoma Gastrodiae extractum that obtains extracting are reclaimed in decompression (2.5 dried handkerchief), dry under the vacuum, the pulverizing 8.5g that weighs is that standard substance are surveyed its extractum total content (ultraviolet spectrometry degree method) with Rhizoma Gastrodiae, and the Rhizoma Gastrodiae general glycoside is at 80-95%, be the Rhizoma Gastrodiae extract that the present invention uses, be called the A component.
2. get cat bean (Levodopa extract) bean 100g dry product (wild or cultivation) 100g, pulverized 80 mesh sieves, put into extractor and add methanol or 80% acetone 400ml, in heating in water bath reflux, extract, (return time 2-3 hour), filter with buchner funnel then, so mode is extracted 4 times, merge extractive liquid,, decompression (2.5 kPas) methanol or decompression (3.5 kPas) acetone reclaim extracting solution, fast extract is handled (extractum with weight resin than 1: 8) with polyamide resin, use earlier the sodium carbonate liquor eluting, use the carbon acid solution eluting of PH4.5 then, collect the eluent of PH4.5, the cat bean extractum that eluent obtains extracting is removed in decompression (2.0 kPas), rapid vacuum drying, the pulverizing 6.5g that weighs is that standard substance are surveyed its extractum total content (ultraviolet spectrometry degree method) with dopamine, and the total DOPA alkali of cat bean is at 70-85%, be the cat bean extract that the present invention uses, be called the B component.(the easy oxidation of this product will be kept in Dark Place)
3; get really (wild) dry product 100g of Fructus clausenae lansii (Clausena lansium); pulverized 40 mesh sieves; put into extractor and add 85% ethanol 500ml; heating and refluxing extraction in water-bath (time 2-3 hour); buchner funnel filters extracting solution; so mode repeats to extract 3 times; merge extractive liquid,, decompression (3.0 kPas) recovered alcohol is handled (extractum and polyamide weight ratio are 1: 6) with extract with polyamide; use earlier the deionized water eluting; collect 90% ethanol eluent then, reclaim under reduced pressure ethanol is to the extractum shape, with 300ml methanol and 100g grain active carbon; the reflux processing of decolouring in 30 minutes; methanol is reclaimed in decompression (3.0 dried handkerchief) then, obtains Fructus clausenae lansii and extracts extractum; dry under vacuum; the pulverizing 5g that weighs is that standard is surveyed its content (ultraviolet spectrometry degree method) with clausenamide, and the Fructus clausenae lansii total ceramide is at 60-75%; be the Fructus clausenae lansii extract that the present invention uses, claim the C component.
4, get Herba Ephedrae (Herba ephedrae) herb dry product (wild) 100g, pulverized 20 mesh sieves, put into extractor and add distilled water 400ml ebuillition of heated backflow (2-3 hour), filter extracting solution at buchner funnel, so mode repeats to extract 3 times, merge extractive liquid,, decompression (2.5 kPas) removes extracting solution to original volume 1/3, is cooled to room temperature, with 300ml toluene extraction 5 times, combining methylbenzene liquid, after the anhydrous calcium oxide drying, toluene, the Herba Ephedrae extractum that obtains extracting are reclaimed in decompression (2.0 kPas), vacuum drying, the pulverizing 9g that weighs is that standard substance are surveyed its total content (ultraviolet spectrometry degree method) with Sanedrine, and Herba Ephedrae total alkaloids is at 40-55%, be the Herba Ephedrae extract that the present invention uses, be called the D component.
Embodiment 2: the proportioning preparation (is represented Rhizoma Gastrodiae extract, is represented cat bean extract, represents Fructus clausenae lansii extract, represents Herba Ephedrae extract with D with C with B with A.)
The said extracted thing is pressed A, B, C, D component, and after weighing respectively in order, uniform mixing behind the adding adjuvant, promptly can be made into the health product adjuvant as various dosage forms such as oral liquid, capsule, tablet, electuary, unguentum.The present invention adopts three kinds of specifications according to operating position:
(1) gets A component 10g, B component 2g, C component 8g, D component 3g, add adjuvant (distilled water) 1000g mix homogeneously, make and set per person's consumption per day (total effective ingredient) product.
(2) get A component 12.5g, B component 2.5g, C component 10g, D component 4g, add adjuvant (solid) 105g mix homogeneously, make and set per person's consumption per day (total effective ingredient) product.
(3) get A component 15g, B component 3g, C component 12g, D component 5g, add adjuvant (solid) 130g or Auxiliary Liquid Material 1010g mix homogeneously, make the product of setting per person's consumption per day (total effective ingredient).
Embodiment 3: the preparation of oral liquid;
Get A component 10g, B component 2g, C component 8g, D component 3g, press A, B, C, D order, be dissolved into respectively in the 800ml distilled water, heated and stirred (85-90 ℃). add adjuvant sucrose 100g, xylitol 3g, protein sugar 10g, sodium benzoate 10g, treat that it all after the dissolving, seethed with excitement 30 minutes, fill is to the oral liquid bottle of 10ml * 100, sterilization treatment is carried out the hygiology item inspection, is oral liquid health product of the present invention after qualified.(instructions of taking: child 3-8 year once a day, each 1; Teenager 9-16 year, every day secondary, each 1).
Embodiment 4: capsular preparation;
Get A component 12.5g, B component 2.5g, C component 10g, D component 4g, press A, B, C, D. order, be blended into 90g starch respectively, after stirring evenly, add 8g sodium bicarbonate, 5g sodium benzoate, 2g tea polyphenols again, after stirring, contain 290mg by A, B, C, every of D total extract, record capsule, carry out hygiology and product quality item inspection, be capsule preparations of the present invention after qualified by the capsule standard requirement.(taking dose, child 3-8 year once a day, each 1; Teenager 9-16 year, every day secondary, each 1)
Embodiment 5: the preparation of dissolved granule;
Get A component 12.5g, B component 2.5g, C component 10g, D component 4g, press A, B, C, D order, sneak into starch respectively, 10g dextrin, 6g sodium bicarbonate, 3g tea polyphenols to 60g, behind the mix homogeneously, make ruined grain, sieve drying, contain A, B, C, D total extract 290mg by every bag of dosage, fill becomes bag, carries out hygiology and product quality item inspection by the dissolved granule standard, is dissolved granule product of the present invention after qualified.
Embodiment 6: the preparation of tablet product;
Get A component 12.5g, B component 2.5g, C component 10g, D component 4g, press A, B, C, D order, sneak into respectively to 60g starch, 20g dextrin, an amount of magnesium stearate mixing, make granule, drying is pressed into every tablet of tablet that contains A, B, C, D total extract 150mg, sugar coating, carry out hygiology and product quality item inspection by the coated tablet standard then, be tablet product of the present invention after qualified).(taking dose, child 3-8 year once a day, each 1; Teenager 9-16 year, every day secondary, each 2).
Claims (2)
1, the health product of a kind of prevention and treatment children and youth hyperkinetic syndrome, its composition is:
Rhizoma Gastrodiae extract 10-15 gram,
Cat bean extract 2-3 gram,
Fructus clausenae lansii extract 8-12 gram,
Herba Ephedrae extract 3-5 gram.
2, the health product of a kind of prevention according to claim 1 and treatment children and youth hyperkinetic syndrome is characterized in that, described each extract is respectively the material that adopts following raw material and technology to obtain:
(1) Rhizoma Gastrodiae extract: get Rhizoma Gastrodiae, pulverize, cross 80 mesh sieves, extract (time 2-3 hour), filter, so repeat to extract 4 times with methanol or 80% ethanol heating (boiling).Merge methanol or ethanol liquid, reclaim under reduced pressure methanol or ethanol liquid get Rhizoma Gastrodiae extract Rhizoma Gastrodiae extract powder, are that standard substance are surveyed its total content with gastrodine, and the Rhizoma Gastrodiae general glycoside is the Rhizoma Gastrodiae extract that the present invention uses at 80-95%,
(2) cat bean extract: get the cat bean, pulverize, cross 80 mesh sieves, with methanol or 80% acetone, heating and refluxing extraction (time 2-3 hour) is filtered methanol or 80% acetone solution, so repeats 4 times, merge methanol or acetone solution, reclaim under reduced pressure methanol or acetone are handled with polyamide resin then, collect the eluent of PH4-5, eluent is removed in decompression, obtaining cat bean extract extract powder, is that standard substance are surveyed its content with dopamine, and the DOPA total alkali is at 70-85%, be the cat bean extract that the present invention uses
(3) Fructus clausenae lansii extract: get Fructus clausenae lansii, pulverize, cross 40 mesh sieves, with 85% ethanol heating and refluxing extraction (time 2-3 hour).Filter ethanol liquid, so repeat 3 times, merge alcoholic extract; reclaim under reduced pressure ethanol; handle with polyamide resin then, collect 90% ethanol eluent, reclaim under reduced pressure ethanol; the decolouring of reuse grain active carbon; obtaining the Fructus clausenae lansii extract extract powder, is that standard substance are surveyed its content with clausenamide, and the clausenamide total alkali is at 60-75%; be the Fructus clausenae lansii extract that the present invention uses
(4) Herba Ephedrae extract: get the Herba Ephedrae herb, pulverize, cross 40 mesh sieves, extract with distilled water heating (boiling), time 2-3 hour, filter extracting solution, furrow are filtered and are caused liquid night, so repeat 2 times, merge extractive liquid,, decompression extracting solution are to volume 1/3ml, then with toluene extraction 3 times, combining extraction liquid, reclaim under reduced pressure toluene.Obtaining the Herba Ephedrae extract extract powder, is that standard substance are surveyed its content with ephedrine, and the Herba Ephedrae total alkali is the Herba Ephedrae extract that the present invention uses at 40-55%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023236 CN1701801A (en) | 2004-05-24 | 2004-05-24 | Health caring product for preventing and treating hyperkinetic syndrome of children and teenagers |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023236 CN1701801A (en) | 2004-05-24 | 2004-05-24 | Health caring product for preventing and treating hyperkinetic syndrome of children and teenagers |
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| CN1701801A true CN1701801A (en) | 2005-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410023236 Pending CN1701801A (en) | 2004-05-24 | 2004-05-24 | Health caring product for preventing and treating hyperkinetic syndrome of children and teenagers |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049435B (en) * | 2006-04-03 | 2011-05-18 | 蹇在金 | Method of preparing nutriment for preventing brain dementia of middle-aged persons and elderly persons |
| CN102267919A (en) * | 2011-05-31 | 2011-12-07 | 南宁市一锋生物科技有限公司 | Preparation method of L-dopa from Mucuna pruriens |
| CN101356975B (en) * | 2008-04-23 | 2012-02-01 | 昆明菌苑食品有限公司 | Health food capable of increasing human immunity and promoting intelligence and strengthening brain and preparation method thereof |
-
2004
- 2004-05-24 CN CN 200410023236 patent/CN1701801A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049435B (en) * | 2006-04-03 | 2011-05-18 | 蹇在金 | Method of preparing nutriment for preventing brain dementia of middle-aged persons and elderly persons |
| CN101356975B (en) * | 2008-04-23 | 2012-02-01 | 昆明菌苑食品有限公司 | Health food capable of increasing human immunity and promoting intelligence and strengthening brain and preparation method thereof |
| CN102267919A (en) * | 2011-05-31 | 2011-12-07 | 南宁市一锋生物科技有限公司 | Preparation method of L-dopa from Mucuna pruriens |
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