CN1698903A - 一种高分子抗肿瘤顺铂药物及其制备方法 - Google Patents
一种高分子抗肿瘤顺铂药物及其制备方法 Download PDFInfo
- Publication number
- CN1698903A CN1698903A CNA2005100721557A CN200510072155A CN1698903A CN 1698903 A CN1698903 A CN 1698903A CN A2005100721557 A CNA2005100721557 A CN A2005100721557A CN 200510072155 A CN200510072155 A CN 200510072155A CN 1698903 A CN1698903 A CN 1698903A
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- Prior art keywords
- rpeg
- high molecular
- cisplatin
- medicine
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
药物 | DImPEG-4000-Pt | DImPEG-6000-Pt | DImPEG-9400-Pt | mPEG-4000-Pt | mPEG-6000-Pt | mPEG-9400-Pt |
铂含量(%) | 87.1 | 89.6 | 87.5 | 85.2 | 88.5 | 84.3 |
药物 | IC50,10-5mol/L |
DImPEG-4000-Pt | 6.265 |
DImPEG-6000-Pt | 27.159 |
DImPEG-9400-Pt | 13.396 |
mPEG-4000-Pt | 61.184 |
mPEG-6000-Pt | 30.725 |
mPEG-9400-Pt | 61.817 |
药物 | LD50,mg/kg |
CDDP | 25.8 |
DImPEG-4000-Pt | 901.5 |
DImPEG-6000-Pt | 988.1 |
DImPEG-9400-Pt | 1013.7 |
mPEG-4000-Pt | 895.6 |
mPEG-6000-Pt | 976.0 |
mPEG-9400-Pt | 1095.3 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2005100721557A CN1332716C (zh) | 2005-05-25 | 2005-05-25 | 一种高分子抗肿瘤顺铂药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2005100721557A CN1332716C (zh) | 2005-05-25 | 2005-05-25 | 一种高分子抗肿瘤顺铂药物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN1698903A true CN1698903A (zh) | 2005-11-23 |
CN1332716C CN1332716C (zh) | 2007-08-22 |
Family
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CNB2005100721557A Expired - Fee Related CN1332716C (zh) | 2005-05-25 | 2005-05-25 | 一种高分子抗肿瘤顺铂药物及其制备方法 |
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CN (1) | CN1332716C (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103732601A (zh) * | 2011-07-09 | 2014-04-16 | 北京市丰硕维康技术开发有限责任公司 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
US9175024B2 (en) | 2011-09-19 | 2015-11-03 | Beijing Fswelcome Technology Development Co., Ltd. | Platinum compound having amino or alkylamino-containing succinic acid derivatives as leaving group, preparation method thereof, and use thereof |
WO2018175601A1 (en) * | 2017-03-22 | 2018-09-27 | The Regents Of The University Of California | Modified platinum compounds and therapeutic uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6235313B1 (en) * | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
EP1329221B1 (en) * | 2000-09-26 | 2006-06-21 | TOUDAI TLO, Ltd. | Polymeric micelle containing cisplatin enclosed therein and use thereof |
WO2003037383A1 (en) * | 2001-10-29 | 2003-05-08 | The Dow Chemical Company | An antineoplastic- dendritic polymer drug delivery system |
-
2005
- 2005-05-25 CN CNB2005100721557A patent/CN1332716C/zh not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103732601A (zh) * | 2011-07-09 | 2014-04-16 | 北京市丰硕维康技术开发有限责任公司 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
EP2740738A4 (en) * | 2011-07-09 | 2015-03-04 | Beijing Fswelcome Technology Dev Co Ltd | PLATINUM COMPOUNDS FOR TREATING CELLULAR PROLIFERATIVE DISEASES, PREPARATION METHODS AND USES THEREOF |
US9138421B2 (en) | 2011-07-09 | 2015-09-22 | Beijing Fswelcome Technology Development Co., Ltd. | Platinum compounds for treating cell proliferative diseases, preparation method and use thereof |
CN103732601B (zh) * | 2011-07-09 | 2016-06-22 | 北京市丰硕维康技术开发有限责任公司 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
US9175024B2 (en) | 2011-09-19 | 2015-11-03 | Beijing Fswelcome Technology Development Co., Ltd. | Platinum compound having amino or alkylamino-containing succinic acid derivatives as leaving group, preparation method thereof, and use thereof |
WO2018175601A1 (en) * | 2017-03-22 | 2018-09-27 | The Regents Of The University Of California | Modified platinum compounds and therapeutic uses thereof |
Also Published As
Publication number | Publication date |
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CN1332716C (zh) | 2007-08-22 |
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