CN1698846A - Cough stopping drip pills and its preparation process - Google Patents
Cough stopping drip pills and its preparation process Download PDFInfo
- Publication number
- CN1698846A CN1698846A CN 200510080066 CN200510080066A CN1698846A CN 1698846 A CN1698846 A CN 1698846A CN 200510080066 CN200510080066 CN 200510080066 CN 200510080066 A CN200510080066 A CN 200510080066A CN 1698846 A CN1698846 A CN 1698846A
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- tincture
- drop pill
- cortex mori
- radix glycyrrhizae
- cough stopping
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Abstract
The invention discloses a cough stopping drip pill whose preparation comprises making powder from root of ballon flower tincture, mulberry bark tincture, licorice root extract, charging ephedrine hydrochloride, mixing the solvent with a drop pill base material, instilling into condensation agent, thus preparing drop pills. Mixing root of ballon flower tincture with mulberry bark tincture, decompressing for reclaiming ethanol, mixing with liquid extract of liquorice, concentrating into thick grease, preparing dry powder through spray drying, mixing the powder with water, charging into molten polyethylene glycol 6000, charging ephedrine hydrochloride so as to obtain turbid liquor, thermal insulating at 80 deg. C, instilling into dimethyl silicon oil, forming drop pills, finally degreasing, drying, and coating for the finished product.
Description
Technical field
The present invention relates to a kind of form improvement of 'Zhenkening ', relate to the advanced person's of this drop pill preparation technology.
Background technology
Antitussive has the peaceful tablet of antitussive, capsule, oral liquid on the market now rather as a kind of nonprescription drugs commonly used.And drop pill is the leading dosage form of modern times of Chinese medicine, and itself and tablet, capsule are compared, and drop pill has molten loosing soon, and drug microparticles is little, is easy to absorb, and can improve the advantage of bioavailability.Compare with oral liquid, drop pill helps preserving, and cost is low, is easy to carry.The child detests difficult patient with gulping down, and can be equivalent to oral liquid facing with before adding very fast molten the loosing of water.And the drop pill production process is simple.Also have many people being engaged in the development of cough stopping drip pills, but preparation method is not quite similar, effect is also different certainly.The cough stopping drip pills of inventor's research does not add other adjuvant, only does substrate with Polyethylene Glycol, good dispersion.Two tinctures and a fluid extract in the prescription are made pressed powder with spray drying method, be beneficial to preservation, the amount of getting during batching is accurate and convenient.Drop pill one-tenth circle property and the hardness prepared with our preparation technology are good, behind the bag film-coat, also do not influence dissolve scattered time limit, increase stability.
Summary of the invention
The object of the present invention is to provide a kind of cough stopping drip pills preparation and preparation technology thereof, adopt a kind of material as drop pill substrate, technology is simple, steady quality.
Cough stopping drip pills of the present invention, the powder so that Radix Platycodonis tincture, Cortex Mori tincture, Radix Glycyrrhizae fluidextract are made adds ephedrine hydrochloride again, need not add other adjuvant, and is only miscible with a kind of drop pill substrate, drips and makes in the condensing agent, makes drop pill.
The substrate of this drop pill is polyethylene glycol 6000.
This condensing agent is a dimethicone.
The consisting of of material in this drop pill: the use of per 1000 balls: Radix Glycyrrhizae fluidextract 16.7ml; Radix Platycodonis tincture 100ml; Ephedrine hydrochloride 0.33g; Cortex Mori tincture 25ml; Polyethylene glycol 6000 24.4～26.3g, distilled water 5.8ml.
This Radix Platycodonis tincture, Cortex Mori tincture, Radix Glycyrrhizae fluidextract powder are made like this: Radix Platycodonis tincture, Cortex Mori tincture are mixed, decompression and reclaim ethanol after, mixes with Radix Glycyrrhizae fluidextract again, it is condensed into thick paste after, the employing spray drying method is made dried powder.
The preparation method of the said goods of the present invention may further comprise the steps:
A: preparation Cortex Mori tincture, Radix Glycyrrhizae fluidextract, Radix Platycodonis tincture dried powder, get Cortex Mori tincture, Radix Glycyrrhizae fluidextract, Radix Platycodonis tincture in proportion, Radix Platycodonis tincture, Cortex Mori tincture are mixed, behind decompression and the recovery ethanol, mix with Radix Glycyrrhizae fluidextract again, after it is condensed into thick paste, adopt spray drying method, make dried powder;
B: the dried powder adding distil water mixing with above-mentioned steps obtains, join again in the fused polyethylene glycol 6000, add ephedrine hydrochloride dissolving and mixing again, make suspension;
C: above-mentioned uniform suspension solution is remained on following of 80 ℃ of constant temperature make 40 ℃ of upper temps, in the dimethicone that the middle and lower part is 4 ℃, condensation forms drop pill;
D: remove the lip-deep silicone oil of drop pill, drying at room temperature, bag film-coat.
Because the present invention only uses a kind of drop pill substrate as dispersant, and is simple relatively on PROCESS FOR TREATMENT, and the quality of dropping pill formulation also has stable assurance, becoming more superior on circle property, shelf-life and the stability simultaneously than mixed-matrix.And dispersion good absorbing effect.
The specific embodiment
To prepare drop pill 1000 balls of the present invention is that example describes:
The dried powder that at first prepares Cortex Mori tincture, Radix Glycyrrhizae fluidextract, Radix Platycodonis tincture.Get Cortex Mori tincture 25ml, Radix Platycodonis tincture 100ml, with above-mentioned two tincture concentrating under reduced pressure and reclaim ethanol, extracting liquorice fluid extract 16.7ml mixes with it then, after it is continued to be condensed into thick paste, adopts spray drying method, and it is standby to make mix dry powders.
Then taking polyethylene glycol 6,000 25 grams, melt to 80 degrees centigrade standby.
The mix dry powders of having made is added in the fused polyethylene glycol 6000, takes by weighing ephedrine hydrochloride 0.33g again and add in the above-mentioned melting mixing liquid, abundant mixing, be incubated 80 degrees centigrade standby.
The preparation condensing agent is put into elongated vessel with refrigerative dimethicone, and the temperature of controlling the upper and lower respectively is 40 degrees centigrade and 4 degrees centigrade.
The system of dripping is dripped the mixed melting liquid insulation that has made for 80 degrees centigrade to make and is controlled well in the dimethicone of temperature, and natural condensation forms drop pill.
Then, behind the bag film-coat, just become finished product of the present invention removing dimethicone residual on the drop pill, at room temperature dry.
Because the polyethylene glycol 6000 among the present invention is single substrate, its consumption can suitably change, and grasps and is advisable at 24.4～26.3g.
The drop pill of the present invention that said process makes, every ball contains: the dried powder that every ball contains Radix Platycodonis tincture, Cortex Mori Ding, Radix Glycyrrhizae fluidextract is total to 18.3mg～19.3mg; Ephedrine hydrochloride 0.33mg; Polyethylene glycol 6000 is 26.3-27.3mg.
Above-mentioned drop pill of the present invention owing to use a kind of substrate, it is simple to have technology, the molten diffusing time of product is short, the molten diffusing time of this product within 15 minutes, the bioavailability height, side effect simultaneously is little, is fit to various crowds and takes.
This drop pill is grown up in use and is taken the 12-24 ball at every turn, gets final product for three times on the one.
Claims (6)
1. cough stopping drip pills is characterized in that: the powder so that Radix Platycodonis tincture, Cortex Mori tincture, Radix Glycyrrhizae fluidextract are made, add ephedrine hydrochloride again, and need not add other adjuvant, only miscible with a kind of drop pill substrate, droplet make in the condensing agent, make drop pill.
2. according to right 1 described cough stopping drip pills, it is characterized in that: the substrate of this drop pill is polyethylene glycol 6000.
3. according to right 1 described cough stopping drip pills, it is characterized in that: this condensing agent is a dimethicone.
4. according to right 1,2 or 3 described cough stopping drip pills, it is characterized in that: the consisting of of material in this drop pill: the use of per 1000 balls: Radix Glycyrrhizae fluidextract 16.7ml; Radix Platycodonis tincture 100ml; Ephedrine hydrochloride 0.33g; Cortex Mori tincture 25ml; Polyethylene glycol 6000 24.4-26.3g, distilled water 5.8ml.
5. according to right 1 described cough stopping drip pills, it is characterized in that: this Radix Platycodonis tincture, Cortex Mori tincture, Radix Glycyrrhizae fluidextract powder are made like this: Radix Platycodonis tincture, Cortex Mori tincture are mixed, behind decompression and the recovery ethanol, mix with Radix Glycyrrhizae fluidextract again, after it is condensed into thick paste, adopt spray drying method, make dried powder.
6. the preparation method of a cough stopping drip pills as claimed in claim 1 is characterized in that may further comprise the steps:
A: preparation Cortex Mori tincture, Radix Glycyrrhizae fluidextract, Radix Platycodonis tincture dried powder, get Cortex Mori tincture, Radix Glycyrrhizae fluidextract, Radix Platycodonis tincture in proportion, Radix Platycodonis tincture, Cortex Mori tincture are mixed, behind decompression and the recovery ethanol, mix with Radix Glycyrrhizae fluidextract again, after it is condensed into thick paste, adopt spray drying method, make dried powder;
B: the dried powder adding distil water mixing with above-mentioned steps obtains, join again in the fused polyethylene glycol 6000, add ephedrine hydrochloride dissolving and mixing again, make suspension;
C: above-mentioned uniform suspension solution is remained on following of 80 ℃ of constant temperature make 40 ℃ of upper temps, in the dimethicone that the middle and lower part is 4 ℃, condensation forms drop pill;
D: remove the lip-deep silicone oil of drop pill, drying at room temperature, bag film-coat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100800667A CN100467034C (en) | 2005-06-29 | 2005-06-29 | Cough stopping drip pills and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100800667A CN100467034C (en) | 2005-06-29 | 2005-06-29 | Cough stopping drip pills and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1698846A true CN1698846A (en) | 2005-11-23 |
| CN100467034C CN100467034C (en) | 2009-03-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100800667A Expired - Fee Related CN100467034C (en) | 2005-06-29 | 2005-06-29 | Cough stopping drip pills and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100467034C (en) |
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2005
- 2005-06-29 CN CNB2005100800667A patent/CN100467034C/en not_active Expired - Fee Related
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| Publication number | Publication date |
|---|---|
| CN100467034C (en) | 2009-03-11 |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090311 Termination date: 20120629 |