CN1695589A - Method for preparing additive of stable micronized medication - Google Patents
Method for preparing additive of stable micronized medication Download PDFInfo
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- CN1695589A CN1695589A CN 200510049806 CN200510049806A CN1695589A CN 1695589 A CN1695589 A CN 1695589A CN 200510049806 CN200510049806 CN 200510049806 CN 200510049806 A CN200510049806 A CN 200510049806A CN 1695589 A CN1695589 A CN 1695589A
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Abstract
A stable microgranular medicine additive for feed is prepared through proportionally mixing raw medicine powder, auxiliary, and adhesive, adding water, mixing, cutting to become particles, sieving by 30 meshes, fluidized dry by fluidized bed while rounding, spraying protective liquid, and vibration classifying.
Description
Technical field
The present invention relates to a kind of preparation method of additive of stable micronized medication.Furtherly, the present invention a kind ofly new carries out the method for micronize and stabilizing treatment with the former powder of medicine and adjunct ingredient, and this additive of stable micronized medication is to be used for the disease prevention of poultry and treatment.
Background technology
As everyone knows, in order to guarantee mixing homogeneity, country expressly provides that the former powder of medicine must not be used for animal and fowl fodder, just so the poultry medicine material must make the additive pre-mixing agent and can add in the feedstuff.In China, the dosage form of the medicated premix of poultry is substantially based on powder, and there is following significant disadvantage in this powder: 1, easily classification, premix are inhomogeneous
The medicated premix powder is generally formed by former powder of medicine and the simple premix of carrier, because the out-of-shape of common carrier, granularity is inhomogeneous, cause by medicine carrying thing content and have notable difference because of the granule size of carrier, often make content of dispersion difference in the different grain size component of final drug additive, therefore the content of dispersion of dust part causes administration inhomogeneous apparently higher than the content of dispersion (2-4 doubly) of granularity major part.And drug dust is the part of very easily losing in the feedstuff course of processing simultaneously.
2, static and refining losses are serious
The medicine powder additive is often because the electrostatic charge effect, be adsorbed on weighing, stirring and the conveying equipment, cause medicine absorption and be detained, and have quite big a part of effective ingredient to lose, cause the deficiency of active constituents of medicine along with the dedusting effect of ventilating and purifying air system.Medicine actual content in the full price batch is lower than the product assurance amount certainly like this.
3, easily cause residual and cross-contamination
Owing to Electrostatic Absorption is trapped in drug component in the feedstuff manufacturing procedure (weighing, stirring and conveying etc.), be easy to contaminate subsequent and produce feedstuff, thereby cause cross-contamination and be with contact scar, and for this toxic dose of Maduramycin Ammonium (＞7ppm) with normal dose (5ppm) differ very little medicine, poisoning very easily takes place.
4, storage and processing stability are poor
The pretreatment of feedstuff processing, granulation, squeeze factors such as spray and oxidation, other chemical reaction and humidity that the lay up period raw material stood, high temperature, high pressure and can destroy a part of medicated premix, common drug active component and air and other responsive thing such as trace element contact area are big, and the ruined probability of medicine is very big.In fact, all there is stability problem in Jue Dabufen medicine powder additive in application.
In order to solve this difficulty, existing many technology all attempt to solve this difficult problem:
At present some Producer for example is dissolved in water-fast Maduramycin Ammonium earlier in the organic solvent such as butyl acetate, benzyl alcohol, then gained solution evenly is sprayed onto on bean cake or the corn core carrier, through stir, mix, dry after the formation pre-mixing agent.This technology evaporate into easy contaminated environment in the air owing to be difficult to accomplish Recovery of Organic Solvent, and not volatile organic solvent is the possibility polluted product also, and organic solvent also easily produces corrosivity to process equipment, and the cost of organic solvent is also higher; Moreover, can guarantee that the spraying of former powder is even although spray, must must there be the carrier of uniformity could guarantee to add to the uniform distribution of medicine behind the animal and fowl fodder very much.Conventional carrier such as bean cake, corn cob is that extremely difficulty is accomplished this point, and not all medicine can both find suitable solvent.
Also there are some Producers that the former powder of medicine such as Maduramycin Ammonium, ivermectin or diclazuril are mixed separately or with corn starch and then directly are pressed into 30～80 purpose granules with Drygranulatemachine; also roughly mix with particle diameter again, promptly get pre-mixing agent after stirring at 30～80 purpose carriers.This technology has overcome the carrier and the inconsistent shortcoming of crude drug particle diameter of powder commonly used, mixing homogeneity is had some improvement, but a problem appears in this technology easily, when crude drug granule and carrier granular unit weight differ big, the classification phenomenon still exists in transporting procedures, if this technology is generalized to other drug, can make the selection space of carrier dwindle greatly, compacting gained granule is too solid, and the disintegrative that enters behind the gastrointestinal tract of livestock and fowls is not good.
In the prior art, have the people that the former powder of medicine and carrier are mixed after, add certain binding agent (as in corn starch, add hot boiled water stir make starch slurry and form), adopt and wave the extruding of extruding granulator and form billet shape granule, dry again and finished product.This method is at present adopted many; but the granule mean diameter that this method makes is bigger than normal; the skewness phenomenon very easily appears after adding feedstuff to; owing to there are not enough gram granule numbers; when searching for food feedstuff, poultry can not guarantee the drug particles of to search for food every day; and because the skewness of medicine, also being prone to searches for food sometimes loses medicament protection less than drug particles, and the more drug particles of then searching for food sometimes produces drug intoxication.
In the prior art, an a kind of step comminution granulation is arranged, multiple powder materials such as the former powder of medicine, carrier are put into the fluidizing fluid-bed fluidisation of carrying out in the lump mix, binding agent is sprayed onto the fluidization interface by the spray gun atomizing, material is condensed into granule and is dried in fluidisation.This method products obtained therefrom can be accomplished the gained even particle distribution substantially, but this method efficient is too low, and cost is higher, and is limited in one's ability during large-scale production.
Summary of the invention
The preparation method that the purpose of this invention is to provide a kind of additive of stable micronized medication.
The step of method is as follows:
(1) 0.5～55% the former powder of medicine that will account for the material gross weight adds wet mixing pelletizer with adjuvant that accounts for thing gross weight 45～99.5% and binding agent, add 20～40% the water account for the material gross weight again, in wet mixing pelletizer, adopt 3000-5000 rev/min rotating speed mixing 3-5 minute, adopt 1500-2000 rev/min rotating speed to mix cutting 3-5 minute again, prepare 20-100 purpose wet granular, be microgranule 1;
(2) microgranule 1 is carried out granulate by wobbler, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
(3) microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.1%～0.3% by spray gun, obtains microgranule 3;
(4) with vibration separation screen microgranule 3 is carried out classification, obtains grain graininess and be the finished product between 30～80 orders, and with fine powder with cross coarse granule and reclaim;
Medicated premix is: 2; the preparation method of a kind of additive of stable micronized medication according to claim 1 is characterized in that described medicated premix is: Maduramycin Ammonium; nicarbazine; ethopabate; narasin; the hydrobromic acid halofuginone hydrobromide; amprolium hydrochloride; clopidol; diclazuril; monensin sodium; bacitracin zinc; kitasamycin; polygynax; the sulphuric acid colomycin; lincomycin hydrochloride; bambermycin; virginiamycin; nosiheptide; roxarsone; tylosin phosphonate; sulfadiazine; in the Flubendazole one or more.
Adjuvant is: corn starch or corn starch and dextrin or corn starch and sucrose or corn starch and sucrose and dextrin, corn starch: dextrin equals 3-4: 1, corn starch: sucrose equals 4-5: 1, and, corn starch: dextrin: sucrose equals 3: 1-2: 1-2.
Binding agent is: sodium carboxymethyl cellulose or starch.
Protection liquid is: a kind of in Oleum Glycines, the paraffin oil or two kinds.
The present invention reasonably makes up by the different process with the micronize production process, and a kind of preparation method of stabilisation microgranule brand-new, that can be applicable to the most drug additive is provided.Make medicated premix have good distributing homogeneity; can reduce the loss in the course of processing; reduce the generation and the cross-contamination of dust; and owing to the contact area that forms stable micronized back active constituents of medicine and air and other responsive thing such as trace element etc. diminishes; the ruined probability of medicine diminishes; thereby improve the stability of medicated premix, have excellent economic benefit and social benefit.Because the method technology is simple, direct,, help applying so only need conventional medical equipment just can realize above-mentioned purpose.
Compared with prior art, the present invention has following advantage: 1, not with an organic solvent, and free from environmental pollution and product; 2, product be evenly distributed, not classification; 3, loss of no dust removal by ventilation and Electrostatic Absorption and cross-contamination; 4, production efficiency height, cost is low.
The specific embodiment
It below is detailed description of the present invention.
Enforcement of the present invention may further comprise the steps:
(1) will account for the former powder (Maduramycin Ammonium of 0.5～55% medicine of material gross weight, nicarbazine, ethopabate, narasin, the hydrobromic acid halofuginone hydrobromide, amprolium hydrochloride, clopidol, diclazuril, monensin sodium, bacitracin zinc, kitasamycin, polygynax, the sulphuric acid colomycin, lincomycin hydrochloride, bambermycin, virginiamycin, nosiheptide, roxarsone, tylosin phosphonate, sulfadiazine, in the Flubendazole one or more) add wet mixing pelletizer with adjuvant that accounts for weight 45～99.5% and binding agent, and add 20～40% the water that accounts for the material gross weight according to the characteristic of wet-mixed, in wet mixing pelletizer, adopt 3000-5000 rev/min rotating speed to mix cutting 3-5 minute, adopt 1500-2000 rev/min rotating speed to mix cutting 3-5 minute again, prepare 20-100 purpose wet granular, be microgranule 1;
(2) microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
(3) microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.1%～0.3% by spray gun, obtains microgranule 3;
(4) with vibration separation screen microgranule 3 is carried out classification, obtain grain graininess and be the finished product between 30～80 orders.And with fine powder with reclaim than coarse granule.
Pharmaceutic adjuvant in the step (1) is: corn starch or corn starch and dextrin or corn starch and sucrose or corn starch and sucrose and dextrin, corn starch: dextrin equals 3-4: 1, corn starch: sucrose equals 4-5: 1, and corn starch: dextrin: sucrose equals 3: 1-2: 1-2.
The binding agent that adds during wet granulation in the step (1) is sodium carboxymethyl cellulose or starch, and the addition of binding agent is the 0.1-0.5% of material gross weight.
Granulate process in the step (2) mainly is by the agglomeration between the squeeze and destroy microgranule, makes the microgranule that enters fluid mapper process can be because of reuniting or the bonding bulky grain that gathers into.
Protection liquid spraying in the step (3) mainly is static and the dust that is used for reducing microgranule.Protection liquid is: the mixture of Oleum Glycines or paraffin oil or Oleum Glycines and paraffin oil, mixed proportion are 1: 1.
Fluid bed in the step (3) requires to have spray gun device.
The magnesium stearate lubricate that can add 0.1-0.5% in the step (1) as required, perhaps for the bitterness that overcomes some drugs and abnormal flavour and add a certain amount of correctives such as A-K sugar or saccharin sodium or essence, consumption is 0.1-0.5%.
Following embodiment can further specify method of the present invention, but and unrestricted range of application of the present invention.Introduced the preparation method of a part of medicated premix in the following embodiment, the medicated premix of other kind can be general with them aspect processing technology.
Embodiment 1: content is the preparation method of 1% stable micronized Maduramycin Ammonium additive:
1, will account for the former powder of Maduramycin Ammonium of material gross weight 1% and account for the corn starch of material gross weight 99.4% and account for the sodium carboxymethyl cellulose of material gross weight 0.5% and account for the A-K sugar of material gross weight 0.1%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 40% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to mix cutting 5 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 5 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 under fluidization wind action, throw circle, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.3% by spray gun, this protection liquid is the mixture of Oleum Glycines and paraffin oil, mixed proportion is 1: 1, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 1% stable micronized Maduramycin Ammonium additive product, fine powder with reclaim than coarse granule.
Embodiment 2: content is the preparation method of 20% stable micronized nicarbazine additive:
1, with the former powder of the nicarbazine that accounts for material gross weight 20% with account for the corn starch of material gross weight 79% and the mixture of sucrose (ratio of corn starch and sucrose equals 5: 1) and account for the starch of material gross weight 0.5% and account for the essence of material gross weight 0.5%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 30% by liquid filling hole when mixing beginning, incorporation time is 8 minutes, adopt 5000 rev/mins rotating speed to mix cutting 4 minutes earlier, adopt 2000 rev/mins rotating speed to mix cutting 4 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 under fluidization wind action, throw circle, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.2% by spray gun, this protection liquid is the mixture of Oleum Glycines and paraffin oil, mixed proportion is 1: 1, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 20% stable micronized nicarbazine additive product, fine powder with reclaim than coarse granule.Embodiment 3: the preparation method of stable micronized nicarbazine synergistic combination additive:
1, with the former powder of the nicarbazine that accounts for material gross weight 25% and account for material gross weight 16% the former powder of ethopabate and account for the corn starch of material gross weight 58.2% and the mixture of sucrose (ratio of corn starch and sucrose equals 4: 1) and account for the starch of material gross weight 0.5% and 0.3% essence, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 30% by liquid filling hole when mixing beginning, incorporation time is 8 minutes, adopt 3000 rev/mins rotating speed to mix cutting 4 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 4 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 under fluidization wind action, throw circle, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.1% by spray gun, this protection liquid is the mixture of Oleum Glycines and paraffin oil, mixed proportion is 1: 1, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be stable micronized nicarbazine synergistic combination additive product, fine powder with reclaim than coarse granule.
Embodiment 4: content is the preparation method of 10% stable micronized narasin additive:
1, with the former powder of the narasin that accounts for material gross weight 10% and account for the corn starch of material gross weight 89% and the mixture of dextrin (ratio of corn starch and dextrin equals 4: 1) and account for the sodium carboxymethyl cellulose of material gross weight 0.5% and 0.5% A-K sugar, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 30% by liquid filling hole when mixing beginning, incorporation time is 8 minutes, adopt 3000 rev/mins rotating speed to mix cutting 4 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 4 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.2% by spray gun, and this protection liquid is Oleum Glycines, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 10% stable micronized narasin additive product, fine powder with reclaim than coarse granule.
Embodiment 5: content is the preparation method of 0.5% stable micronized diclazuril additive:
1, with the former powder of the diclazuril that accounts for material gross weight 0.5% with account for the corn starch of material gross weight 99% and the mixture of dextrin (ratio of corn starch and dextrin equals 3: 1) and account for the sodium carboxymethyl cellulose of material gross weight 0.5%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 40% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to mix cutting 5 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 5 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.2% by spray gun, and this protection liquid is Oleum Glycines, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 10% stable micronized narasin additive product, fine powder with reclaim than coarse granule.
Embodiment 6: content is the preparation method of 5% stable micronized monensin sodium additives:
1, to account for the former powder of monensin sodium of material gross weight 5% and account for the corn starch of material gross weight 94.3% and the mixture of dextrin (ratio of corn starch and dextrin equals 3: 1) and account for the starch of material gross weight 0.1% and account for the magnesium stearate of material gross weight 0.5% and account for the essence of material gross weight 0.1%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 40% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to mix cutting 5 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 5 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.3% by spray gun, and this protection liquid is Oleum Glycines, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 5% stable micronized monensin sodium additives product, fine powder with reclaim than coarse granule.
Embodiment 7: content is the preparation method of 10% stable micronized bacitracin zinc additive:
1, with the former powder of the bacitracin zinc that accounts for material gross weight 10% with account for the corn starch of material gross weight 88.9% and the mixture of dextrin (ratio of corn starch and dextrin equals 3: 1) and account for the sodium carboxymethyl cellulose of material gross weight 0.5% and account for the magnesium stearate of material gross weight 0.5% and account for the saccharin sodium of material gross weight 0.1%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 35% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to mix cutting 5 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 5 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.1% by spray gun, and this protection liquid is Oleum Glycines, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 10% stable micronized bacitracin zinc additive product, fine powder with reclaim than coarse granule.
Embodiment 8: content is 55% stable micronized Kitasamycin addictive preparation method:
1, with the former powder of the kitasamycin that accounts for material gross weight 55% with account for the corn starch of material gross weight 44.4% and the mixture of sucrose (ratio of corn starch and sucrose equals 4: 1) and account for the sodium carboxymethyl cellulose of material gross weight 0.1% and account for the A-K sugar of material gross weight 0.5%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 20% by liquid filling hole when mixing beginning, incorporation time is 6 minutes, adopt 3000 rev/mins rotating speed to mix cutting 3 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 3 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 gross weights 0.1% by spray gun, and this protection liquid is paraffin oil, sprays to obtain microgranule 3 after protecting liquid;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 55% stable micronized Kitasamycin additive product, fine powder with reclaim than coarse granule.
Embodiment 9: content is 22% stable micronized polygynax addictive preparation method:
1, will account for material gross weight 22% the former powder of polygynax, account for material gross weight 77.4% corn starch, account for the sodium carboxymethyl cellulose of material gross weight 0.5% and account for the saccharin sodium of material gross weight 0.1%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 25% by liquid filling hole when mixing beginning, incorporation time is 8 minutes, adopt 3000 rev/mins rotating speed to mix cutting 4 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 4 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.2% by spray gun, and this protection liquid is paraffin oil, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 22% stable micronized polygynax additive product, fine powder with reclaim than coarse granule.
Embodiment 10: content is 10% stable micronized lincomycin addictive preparation method:
1, with the former powder of the lincomycin that accounts for material gross weight 10%, account for the corn starch of material gross weight 89.4% and the mixture of sucrose and dextrin (corn starch: dextrin: sucrose equals 3: 1: 1) and account for the starch of material gross weight 0.5% and account for the essence of material gross weight 0.1%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 30% by liquid filling hole when mixing beginning, incorporation time is 8 minutes, adopt 3000 rev/mins rotating speed to cut earlier 4 minutes, adopt 1500 rev/mins rotating speed to cut again 4 minutes, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, spray into the protection liquid that accounts for microgranule 2 weight 0.2% by spray gun when closely dried, this protection liquid is Oleum Glycines, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 10% stable micronized lincomycin additive product, fine powder with reclaim than coarse granule.
Embodiment 11: the preparation method of stable micronized Kitasamycin, polygynax synergistic combination:
1, account for the former powder of polygynax of material gross weight 10%, account for the former powder of Kitasamycin and the corn starch that accounts for material gross weight 67.4% of material gross weight 22%, sucrose, the mixture of dextrin (corn starch: dextrin: sucrose equals 3: 2: 2) and account for the starch of material gross weight 0.2% and account for the saccharin sodium of material gross weight 0.5%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 20% by liquid filling hole in the mixed process, incorporation time is 8 minutes, adopt 3000 rev/mins rotating speed to cut earlier 4 minutes, adopt 1500 rev/mins rotating speed to cut again 4 minutes, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.3% by spray gun, and this protection liquid is paraffin oil, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be the neomycin that contains 10% Kitasamycin and 22% stable micronized Kitasamycin, polygynax synergistic combination additive product, fine powder with reclaim than coarse granule.
Embodiment 12: content is 10% stable micronized tylosin phosphonate addictive preparation method:
1, the former powder of material gross weight 10% tylosin phosphonate will be accounted for, account for the corn starch of material gross weight 89.6% and the mixture of sucrose and dextrin (corn starch: dextrin: sucrose equals 3: 1: 2) and account for material gross weight 0.3% starch and the saccharin sodium that accounts for material gross weight 0.1%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 30% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to cut earlier 5 minutes, adopt 1500 rev/mins rotating speed to cut again 5 minutes, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.3% by spray gun, and this protection liquid is Oleum Glycines, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 10% stable micronized tylosin phosphonate additive product, fine powder with reclaim than coarse granule.
Embodiment 13: content is 2% stable micronized sulphuric acid colomycin addictive preparation method:
1, to account for the former powder of material gross weight 2% sulphuric acid colomycin, account for the corn starch of material gross weight 97% and the mixture of sucrose and dextrin (corn starch: dextrin: sucrose equals 3: 2: 1) and account for material gross weight 0.5% sodium carboxymethyl cellulose and the magnesium stearate that accounts for material gross weight 0.5%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 40% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to cut earlier 5 minutes, adopt 1500 rev/mins rotating speed to cut again 5 minutes, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.1% by spray gun, and this protection liquid is Oleum Glycines, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 2% stable micronized sulphuric acid colomycin additive product, fine powder with reclaim than coarse granule.
Embodiment 14: content is 8% stable micronized bambermycin addictive preparation method:
1, to account for the former powder of material gross weight 8% sulphuric acid colomycin, account for the corn starch of material gross weight 91.5% and the mixture of sucrose and dextrin (corn starch: dextrin: sucrose equals 3: 1: 1) and account for the starch of material gross weight 0.4% and account for the magnesium stearate of material gross weight 0.1%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 35% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to cut earlier 5 minutes, adopt 1500 rev/mins rotating speed to cut again 5 minutes, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.1% by spray gun, and this protection liquid is paraffin oil, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 8% stable micronized bambermycin additive product, fine powder with reclaim than coarse granule.
Embodiment 15: content is 10% stable micronized roxarsone addictive preparation method:
1, to account for the former powder of material gross weight 10% roxarsone, account for the corn starch of material gross weight 89.3% and account for material gross weight 0.4% sodium carboxymethyl cellulose and account for the magnesium stearate of material gross weight 0.2% and account for 0.1% A-K sugar of material gross weight, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 25% by liquid filling hole when mixing beginning, incorporation time is 10 minutes, adopt 3000 rev/mins rotating speed to mix cutting 5 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 5 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.1% by spray gun, and this protection liquid is paraffin oil, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 10% stable micronized roxarsone additive product, fine powder with reclaim than coarse granule.
Embodiment 16: content is 50% stable micronized Flubendazole addictive preparation method:
1, to account for the former powder of material gross weight 50% Flubendazole, account for the corn starch of material gross weight 49.5% and account for material gross weight 0.1% dextrin and account for the magnesium stearate of material gross weight 0.1% and account for 0.1% saccharin sodium of material gross weight and account for the essence of material gross weight 0.2%, add in the high speed wet-mixed machine and mix, add the distilled water that accounts for material gross weight 20% by liquid filling hole when mixing beginning, incorporation time is 6 minutes, adopt 3000 rev/mins rotating speed to mix cutting 3 minutes earlier, adopt 1500 rev/mins rotating speed to mix cutting 3 minutes again, prepare 20-100 purpose wet granular, be microgranule 1;
2, microgranule 1 carried out granulate by wobbler, overcome its bonding and agglomeration after granulation, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
3, microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.1% by spray gun, and this protection liquid is paraffin oil, prepares microgranule 3;
4, with vibration separation screen microgranule 3 is carried out classification, obtain the finished product of grain graininess between 30～80 orders.Be content and be 50% stable micronized Flubendazole additive product, fine powder with reclaim than coarse granule.
Claims (7)
1, a kind of preparation method of additive of stable micronized medication is characterized in that the step of method is as follows:
(1) 0.5～55% the former powder of medicine that will account for the material gross weight adds wet mixing pelletizer with adjuvant that accounts for thing gross weight 45～99.5% and binding agent, add 20～40% the distilled water account for the material gross weight again, in wet mixing pelletizer, adopt 3000-5000 rev/min rotating speed mixing 3-5 minute, adopt 1500-2000 rev/min rotating speed mixing 3-5 minute again, prepare 20-100 purpose wet granular, be microgranule 1;
(2) microgranule 1 is carried out granulate by wobbler, and to make be 30 purpose screen clothes by fineness all, microgranule 2;
(3) microgranule 2 is changed over to the board-like fluid bed of eddy flow and carry out fluidized drying, and make microgranule 2 throw circle under fluidization wind action, dry back sprays into the protection liquid that accounts for microgranule 2 weight 0.1%～0.3% by spray gun, obtains microgranule 3;
(4) with vibration separation screen microgranule 3 is carried out classification, obtains grain graininess and be the medicated premix finished product between 30～80 orders, and with fine powder with cross coarse granule and reclaim.
2, the preparation method of a kind of additive of stable micronized medication according to claim 1 is characterized in that the former powder of described medicine is: one or more in Maduramycin Ammonium, nicarbazine, ethopabate, narasin, hydrobromic acid halofuginone hydrobromide, amprolium hydrochloride, clopidol, diclazuril, monensin sodium, bacitracin zinc, kitasamycin, polygynax, sulphuric acid colomycin, lincomycin hydrochloride, bambermycin, virginiamycin, nosiheptide, roxarsone, tylosin phosphonate, sulfadiazine, the Flubendazole.
3, the preparation method of a kind of additive of stable micronized medication according to claim 1 is characterized in that described adjuvant is: corn starch.
4, the preparation method of a kind of additive of stable micronized medication according to claim 1; it is characterized in that described adjuvant is: corn starch and dextrin or rice starch and sucrose; the ratio of corn starch and dextrin equals 3-4: 1, and the ratio of corn starch and sucrose equals 4-5: 1.
5, the preparation method of a kind of additive of stable micronized medication according to claim 1, it is characterized in that described adjuvant is: corn starch and sucrose and dextrin, corn starch: dextrin: sucrose equals 3: 1-2: 1-2.
6, the preparation method of a kind of additive of stable micronized medication according to claim 1 is characterized in that described binding agent is: sodium carboxymethyl cellulose or starch.
7, the preparation method of a kind of additive of stable micronized medication according to claim 1 is characterized in that described protection liquid is: a kind of in Oleum Glycines and the paraffin oil or two kinds.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101273968B (en) * | 2008-05-06 | 2010-06-09 | 浙江汇能动物药品有限公司 | Maduramicin ammonium solid dispersion and method for preparing the same |
| CN101611766B (en) * | 2009-07-16 | 2012-06-06 | 无锡正大畜禽有限公司 | Production method of enteric-coated kitasamycin for feed |
| CN102697660A (en) * | 2012-06-04 | 2012-10-03 | 贵州景峰注射剂有限公司 | Method for eliminating static electricity in micro-pill room |
| CN104208657A (en) * | 2014-09-10 | 2014-12-17 | 河南牧翔动物药业有限公司 | Virginiamycin soluble powder and preparation method thereof |
| CN105434367A (en) * | 2016-01-29 | 2016-03-30 | 黄利文 | Soluble nicarbazin premixing agent and preparation method thereof |
| CN108902480A (en) * | 2018-07-27 | 2018-11-30 | 河南大华生物技术有限公司 | A kind of method of micro the additive uniformity and bioavilability in raising feed |
| US10694683B2 (en) * | 2017-05-20 | 2020-06-30 | Insectergy, Llc | Cannabis farming systems and methods |
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| US3453368A (en) * | 1966-01-13 | 1969-07-01 | Hoffmann La Roche | Smaller high potency compressed tablets of ascorbic acid |
| JPS58403B2 (en) * | 1975-07-24 | 1983-01-06 | 武田薬品工業株式会社 | L- Ascorbine Sanseizaino Seizouhou |
| JPS5759803A (en) * | 1980-09-30 | 1982-04-10 | Takeda Chem Ind Ltd | Granule of l-sodium ascorbate, its preparation, and tablet comprising it |
| CN1065797A (en) * | 1992-05-22 | 1992-11-04 | 东北第六制药厂二分厂 | The manufacture method of infantile stomach medicine pill " Weibaowan " |
| CN1068960A (en) * | 1992-07-25 | 1993-02-17 | 广州白云山制药总厂 | A kind of production technology of Chinese patent medicine capsule |
| FR2720631B1 (en) * | 1994-06-03 | 1996-07-12 | Rhone Poulenc Rorer Sa | Preparation process and beads obtained containing an active ingredient having an undefined melting point. |
| JP4098376B2 (en) * | 1996-09-05 | 2008-06-11 | ビーエーエスエフ ソシエタス・ヨーロピア | Water-soluble vitamin composition having excellent tablet characteristics and method for producing the same |
| JP2000128774A (en) * | 1998-10-26 | 2000-05-09 | Tanabe Seiyaku Co Ltd | Production of globular, fine grain including medicine |
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- 2005-05-24 CN CNB2005100498060A patent/CN100431515C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101273968B (en) * | 2008-05-06 | 2010-06-09 | 浙江汇能动物药品有限公司 | Maduramicin ammonium solid dispersion and method for preparing the same |
| CN101611766B (en) * | 2009-07-16 | 2012-06-06 | 无锡正大畜禽有限公司 | Production method of enteric-coated kitasamycin for feed |
| CN102697660A (en) * | 2012-06-04 | 2012-10-03 | 贵州景峰注射剂有限公司 | Method for eliminating static electricity in micro-pill room |
| CN102697660B (en) * | 2012-06-04 | 2014-02-12 | 贵州景峰注射剂有限公司 | Method for eliminating static electricity in micro-pill room |
| CN104208657A (en) * | 2014-09-10 | 2014-12-17 | 河南牧翔动物药业有限公司 | Virginiamycin soluble powder and preparation method thereof |
| CN105434367A (en) * | 2016-01-29 | 2016-03-30 | 黄利文 | Soluble nicarbazin premixing agent and preparation method thereof |
| US10694683B2 (en) * | 2017-05-20 | 2020-06-30 | Insectergy, Llc | Cannabis farming systems and methods |
| CN108902480A (en) * | 2018-07-27 | 2018-11-30 | 河南大华生物技术有限公司 | A kind of method of micro the additive uniformity and bioavilability in raising feed |
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Assignee: ZHEJIANG HUIJIA BIOTECHNOLOGY CO., LTD. Assignor: Zhejiang University Contract record no.: 2011330001043 Denomination of invention: Method for preparing additive of stable micronized medication Granted publication date: 20081112 License type: Exclusive License Open date: 20051116 Record date: 20110803 |
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