CN1691953A - Method for producing avocado leaves extract rich in furan lipids - Google Patents
Method for producing avocado leaves extract rich in furan lipids Download PDFInfo
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- CN1691953A CN1691953A CNA038232499A CN03823249A CN1691953A CN 1691953 A CN1691953 A CN 1691953A CN A038232499 A CNA038232499 A CN A038232499A CN 03823249 A CN03823249 A CN 03823249A CN 1691953 A CN1691953 A CN 1691953A
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- 244000025272 Persea americana Species 0.000 title claims abstract description 39
- 235000008673 Persea americana Nutrition 0.000 title claims abstract description 39
- 239000000284 extract Substances 0.000 title claims abstract description 29
- 150000002240 furans Chemical class 0.000 title claims abstract description 23
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 39
- 238000010438 heat treatment Methods 0.000 claims abstract description 7
- 238000007738 vacuum evaporation Methods 0.000 claims abstract description 7
- 238000001172 liquid--solid extraction Methods 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 41
- 239000000419 plant extract Substances 0.000 claims description 25
- 239000002904 solvent Substances 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 230000018044 dehydration Effects 0.000 claims description 8
- 238000006297 dehydration reaction Methods 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 235000015241 bacon Nutrition 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 230000026030 halogenation Effects 0.000 claims description 2
- 238000005658 halogenation reaction Methods 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 description 10
- 238000000605 extraction Methods 0.000 description 7
- 238000004380 ashing Methods 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 6
- 238000000227 grinding Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000003039 volatile agent Substances 0.000 description 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- BHKKSKOHRFHHIN-MRVPVSSYSA-N 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound N[C@H](C)C1=C(CN2C(NC(C3=C2C=CN3)=O)=S)C=CC(=C1)Cl BHKKSKOHRFHHIN-MRVPVSSYSA-N 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical group CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 241000091577 Mexicana Species 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011949 solid catalyst Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/02—Pretreatment
- C11B1/04—Pretreatment of vegetable raw material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a method for producing an avocado leaves extract which is rich in furan lipids and whose raw material is embodied in the form of avocado leaves. The inventive method involves the following stages: a liquid-solid extraction which is followed by a vacuum evaporation and a heat treatment at a temperature ranging from 80 DEG C to 120 DEG C during the time of 5 to 72 hours. Two last stages can be carried out in said sequence or in another one.
Description
The present invention relates to be used to prepare the method for the avocado leaves extract that is rich in furan lipids.
Known American Avocado Tree comprises specific furan type lipid, and be the linoleic acid furan wherein main the composition:
So, according to the present invention, term " American Avocado Tree furan lipids " is meant the chemical compound that meets (comply with) following formula:
Wherein, R is saturated C
11-C
19, be preferably C
13-C
17, linear hydrocarbon chain or comprise one or more ethylene or the acetylene unsaturates.
These American Avocado Tree furan lipids are described in Farines especially, M. etc., 1995, J.ofAm.Oil Chem.Sco.72,473.
At present, be generally used for preparing the synthetic method employing American Avocado Tree fruit of furan lipids as raw material.
In general, in view of the American Avocado Tree furan lipids for connective tissue, particularly at the diseases associated with inflammation useful and importance of therapeutical effect on therapeutics in arthritis, periodontitis (paradontitis) and the scleroderma for example, owing to its cost height, the alternative preparation method of seeking described American Avocado Tree furan lipids is very significant simultaneously.
So, this application has is through developing a kind of method, makes the avocado leaves plant extract that may obtain to be rich in furan lipids, and promptly furan lipids content changes between the 20-80%, is preferably 30-50%.
The raw material of this method is made up of avocado leaves, comprises the steps:
-liquid-solid extraction step, then carry out vacuum evaporation and
-heating steps between 80-120 ℃.
These two steps can be carried out with this order or with reverse order.
Avocado leaves can be subordinated on the avocado of following kind and obtain: Hass, Fuerte, Ettinger, Bacon, Nabal, Anaheim, Lula, Reed, Zutano, Queen, Criola Salva, Mexicana Canta, Region Dschang, Hall, Booth, Peterson, Collinson Red or Alpha Krome and more favourablely be kind Hass, Fuerte and Reed.
There is multiple solvent can be used to before extraction, dewater in the liquid-solid extraction step.Solvent can be selected from alkane, halogenation alkane, ether, ester, alcohol, aromatic and supercritical fluid.Preferred individually or the hexane in mixture, ethanol, methanol, chloroform, dichlorotoleune and ethyl acetate.
No matter be directly on leaf or in the plant extract stage, to carry out heat treatment step, all under the temperature between 80-120 ℃, carry out.This heat treated continues 5-72h.
According to method of the present invention, heating steps can exist or carry out when not having acidic catalyst.
The term acidic catalyst is generalized, be meant so-called uniform mineral and organic catalyst, for example hydrochloric acid, sulphuric acid, acetic acid or secondary toluenesulfonic acid (paratoluenesulphonicacid), but be preferably uneven solid catalyst, for example silicon dioxide, aluminium oxide, silica-alumina, zirconium oxide, zeolite, acidic resins.Should select the acidic alumina with big specific surface area (specific area) especially for use, promptly specific surface area is at least 200m
2/ g.
Before liquid-solid extracted, this method may also comprise avocado leaves dehydration.
Term avocado leaves dehydration refers generally to the technology that is used to extract moisture from chemical compound of using all those skilled in the art to know.These technology are included in the thermal current or in controllable gas (for example nitrogen), under atmospheric pressure or in the vacuum, carry out drying with thick-layer or thin layer, and microwave drying, spray drying, lyophilization and in solution (directly infiltration) or in solid phase (for example dry in osmotic bag) permeating and dewatering.
As total principle, no matter use which kind of method, the temperature in the dehydration preferably is maintained at and is lower than or equals 80 ℃.
In addition, in protection scope of the present invention, preferably when reaching 5% threshold value, residual moisture stops dehydration.
In protection scope of the present invention, carry out commercial Application and reduce cost for easier, preferably in circulation dryer,, in thermal current, dry down at 70-75 ℃ with thin layer.Operating process can change between 5-72h.
According to first alternative embodiment, this method is carried out according to the following steps order:
-step 1: the heat treated avocado leaves,
-step 2: liquid-solid extracts avocado leaves,
-step 3: vacuum evaporating solvent is up to obtaining solvent-free plant extract.
According to second alternative embodiment, this method is carried out according to the following steps order:
-step l: liquid-solid extracts avocado leaves,
-step 2: vacuum evaporating solvent is up to obtaining not solvent-laden plant extract,
-step 3: heat treated plant extract.
According to last alternative embodiment, this method is carried out according to the following steps order:
-step 1: the dehydration avocado leaves,
-step 2: liquid-solid extracts avocado leaves,
-step 3: vacuum evaporating solvent is up to obtaining plant extract,
-step 4: heat treated plant extract.
In the scope of the inventive method, before implementing any operation, leaf is advantageously ground.
At last, the present invention relates to the avocado leaves plant extract by being easy to obtain according to method of the present invention, these methods comprise its all alternative embodiment.
Below, illustrate the present invention with non-limiting example.
Embodiment 1: the avocado leaves that grinds 1kg Hass kind up hill and dale.The grinding product (320g) that obtains is contacted with 2 liters of ethanol, and backflow 5h.In case cooling, at Bu Shi (B ü chner) funnel filtering mixt, filtering residue 100ml washing with alcohol three times.Use the rotary evaporator vacuum evaporating solvent then, after removing solvent fully, vacuum extraction 1h.Then the extract that obtains is placed in the baking box, heats 24h down at 100 ℃, and analyze.Adopt this method to obtain the 23g extract.
This extract of physics and chemistry and chromatographic analysis obtains following result:
-ashing is residual:＜0.1%
-volatile compound content:＜0.1%
-furan lipids content: 42%
Embodiment 2: the avocado leaves that grinds 1kg Fuerte kind up hill and dale.The grinding product (305g) that obtains is contacted with 2 liters of hexanes, and backflow 5h.In case cooling, at the buchner funnel filtering mixt, filtering residue 100ml hexane wash three times.After the collection, at Na
2SO
4Go up dry hexane phase.Use rotary evaporator vacuum evaporation hexane then, after removing solvent fully, vacuum extraction 1h.Then the extract that obtains is placed in the baking box, heats 24h down at 100 ℃, and analyze.Adopt this method to obtain the 26g extract.
This extract of physics and chemistry and chromatographic analysis obtains following result:
-ashing is residual:＜0.1%
-volatile compound content:＜0.1%
-furan lipids content: 46%
Embodiment 3: the avocado leaves that grinds 1kg Hass kind up hill and dale.During stirring, with grinding product and 10 liters of methanol, 10 liters of chloroforms contact 5h with 10 liters of saline (1%NaCl).Centrifugal mixture and remove solid precipitation then.The liquid phase of bottom is extracted, at Na
2SO
4Last dry.Use the rotary evaporator vacuum evaporating solvent then, after removing solvent fully, vacuum extraction 1h.Then the extract that obtains is placed in the baking box, heats 24h down at 100 ℃, and analyze.Adopt this method to obtain the 21g extract.
This extract of physics and chemistry and chromatographic analysis obtains following result:
-ashing is residual:＜0.1%
-volatile compound content:＜0.1%
-furan lipids content: 46%
Embodiment 4: the avocado leaves that grinds 1kg Hass kind up hill and dale.Grinding product is used oven dried 24h down at 110 ℃ in thermal current then.The exsiccant material of 302g is extracted then.This material contacts with 2 liters of hexanes then, and backflow 5h.In case cooling, at the buchner funnel filtering mixt, filtering residue 100ml hexane wash three times.Use rotary evaporator vacuum evaporation hexane then, and after removing solvent fully, vacuum extraction 1h.Adopt this method to obtain the 31g extract.
This extract of physics and chemistry and chromatographic analysis obtains following result:
-ashing is residual:＜0.1%
-volatile compound content:＜0.1%
-furan lipids content: 41%
Embodiment 5: the avocado leaves that grinds 1kg Hass kind up hill and dale.Grinding product is used oven dried 72h down at 70 ℃ in thermal current then.The exsiccant material of 315g is extracted then.The residual moisture that is present in the leaf is 4.8%.Then this dehydrated material is contacted with 2 liters of hexanes, and backflow 5h.In case cooling, at the buchner funnel filtering mixt, filtering residue 100ml hexane wash three times.Use rotary evaporator vacuum evaporation hexane then, and after removing solvent fully, vacuum extraction 1h.Then the extract that obtains is placed in the baking box, heats 24h down at 100 ℃, and analyze.Adopt this method to obtain the 23g extract.
This extract of physics and chemistry and chromatographic analysis obtains following result:
-ashing is residual:＜0.1%
-volatile compound content:＜0.1%
-furan lipids content: 38%
Do not carry out the comparing embodiment/method of the high temperature heating of leaf
Embodiment: the avocado leaves that grinds 1kg Hass kind up hill and dale.Grinding product is used oven dried 96h down at 60 ℃ in thermal current then.The exsiccant material of 307g is extracted then.Then this material is contacted with 2 liters of hexanes, and backflow 5h.In case cooling, at the buchner funnel filtering mixt, filtering residue 100ml hexane wash three times.Under 60 ℃, use rotary evaporator vacuum evaporation hexane then, and after removing solvent fully, vacuum extraction 1h.Adopt this method to obtain the 27g extract.
This extract of physics and chemistry and chromatographic analysis obtains following result:
-ashing is residual:＜0.1%
-volatile compound content:＜0.1%
-furan lipids content: 2%
Conclusion: when not carrying out the high-temperature heating treatment leaf, the extract that obtains the leaf of extract that obtains or or dehydration new from aquatic foods after with solvent extraction, the final extract of acquisition contain furan lipids (content is lower than 5%) hardly.
Claims (12)
1. the method for plant extract of furan lipids is rich in preparation, it is characterized in that raw material is made up of avocado leaves, and this method comprises the steps:
-liquid-solid extraction step then carries out vacuum evaporation,
-heat treatment step between 80-120 ℃,
Wherein said two steps can this orders or are carried out with opposite order.
2. the method for the plant extract of furan lipids is rich in preparation, it is characterized in that avocado leaves can be subordinated to the avocado acquisition of following kind: Hass, Fuerte, Ettinger, Bacon, Nabal, Anaheim, Lula, Reed, Zutano, Queen, Criola Salva, MexicanaCanta, Region Dschang, Hall, Booth, Peterson, Collinson Red or Alpha Krome.
3. be rich in the method for the plant extract of furan lipids according to any one preparation of claim 1 or 2, it is characterized in that heat treated carries out the time at 5-72h.
4. be rich in the method for the plant extract of furan lipids according to any one the preparation of claim 1-3, it is characterized in that the suitable solvent in the liquid-solid extraction step is selected from alkane, halogenation alkane, ether, ester, alcohol, aromatic and supercritical fluid.
5. be rich in the method for the plant extract of furan lipids according to the preparation of claim 4, it is characterized in that the suitable solvent in the liquid-solid extraction step is selected from individually or mixes hexane, ethanol, methanol, chloroform, dichlorotoleune and the ethyl acetate of use.
6. be rich in the method for the plant extract of furan lipids according to the preparation of claim 1-5, it is characterized in that this method is included in the avocado leaves drying steps before extracting.
7. be rich in the method for the plant extract of furan lipids according to the preparation of claim 6, it is characterized in that this dewatering is selected from thermal current or drying in controllable gas, under atmospheric pressure or in the vacuum, carry out drying with thick-layer or thin layer, microwave drying, spray drying, lyophilization and permeating and dewatering in solution or in solid phase.
8. be rich in the method for the plant extract of furan lipids according to the preparation of claim 7, it is characterized in that this dehydration is included in the circulation dryer, with thin layer, in thermal current, dry down at 70-75 ℃.
9. be rich in the method for the plant extract of furan lipids according to any one the preparation of claim 1-8, it is characterized in that this method carries out according to the following steps order:
-step 1: the heat treated avocado leaves,
-step 2: liquid-solid extracts avocado leaves,
-step 3: vacuum evaporating solvent is up to obtaining solvent-free plant extract.
10. be rich in the method for the plant extract of furan lipids according to any one the preparation of claim 1-8, it is characterized in that this method carries out according to the following steps order:
-step 1: liquid-solid extracts avocado leaves,
-step 2: vacuum evaporating solvent is up to obtaining not solvent-laden plant extract,
-step 3: heat treated plant extract.
11. be rich in the method for the plant extract of furan lipids according to any one the preparation of claim 1-8, it is characterized in that this method carries out according to the following steps order:
-step 1: the dehydration avocado leaves,
-step 2: liquid-solid extracts avocado leaves,
-step 3: vacuum evaporating solvent is up to obtaining plant extract,
-step 4: heat treated plant extract.
12, the avocado leaves plant extract that adopts any one the method according to claim 1-11 to be easy to obtain.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0209666A FR2843027B1 (en) | 2002-07-30 | 2002-07-30 | PROCESS FOR OBTAINING AN EXTRACT OF AVOCADO LEAVES RICH IN FURNA LIPIDS |
| FR02/09666 | 2002-07-30 | ||
| US10/206,995 | 2002-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1691953A true CN1691953A (en) | 2005-11-02 |
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ID=30129538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA038232499A Pending CN1691953A (en) | 2002-07-30 | 2003-07-28 | Method for producing avocado leaves extract rich in furan lipids |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN1691953A (en) |
| FR (1) | FR2843027B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104172171A (en) * | 2014-08-27 | 2014-12-03 | 金湘范 | Raw extract of leafy plants as well as preparation method and application |
| CN105392873A (en) * | 2013-06-04 | 2016-03-09 | 普瓦图-夏朗德萨姆瓦拉格罗可再生碳公司 | Processes for selective extraction of unsaponifiable materials from renewable raw materials by liquid-liquid extraction in the presence of a cosolvent |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2869541B1 (en) | 2004-04-30 | 2007-12-28 | Expanscience Sa Lab | USE OF A COMPOSITION COMPRISING D-MANNOHEPTULOSE AND / OR PERSEITOL FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH A CHANGE IN INITIATED IMMUNITY |
| US9089576B2 (en) | 2004-04-30 | 2015-07-28 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency or oxidative stress or skin ageing or dry skin |
| FR2869543B1 (en) | 2004-04-30 | 2006-07-28 | Expanscience Laboratoires Sa | MEDICAMENT COMPRISING A PEPTIDE AVOCADO EXTRACT FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH A DEFICIENCY OF THE IMMUNE SYSTEM |
| FR2953722B1 (en) | 2009-12-16 | 2012-03-09 | Expanscience Lab | COMPOSITION COMPRISING AT LEAST ONE C7 SUGAR FOR THE TREATMENT OF ALOPECIA, FOR THE COSMETIC TREATMENT OF PHANES, AND FOR THE CARE OF HAIR, CILES OR NAILS |
| FR3001889B1 (en) | 2013-02-11 | 2021-02-12 | Expanscience Lab | USE OF A COMPOSITION CONTAINING AVOCADO PERSEOSE IN THE PROTECTION OF EPIDERMAL STEM CELLS. |
| FR3098405B1 (en) | 2019-07-12 | 2021-06-25 | Expanscience Lab | Composition comprising passionflower seed polyphenols, avocado peptides and witch hazel extract and use to treat and / or prevent stretch marks |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2678632B1 (en) * | 1991-07-03 | 1994-09-02 | Pharmascience Lab | PROCESS FOR THE PREPARATION OF THE UNSAPONIFIABLE LAWYER FOR IMPROVING ITS CONTENT IN ONE OF ITS FRACTIONS SAID H |
| FR2798667B1 (en) * | 1999-09-22 | 2001-12-21 | Pharmascience Lab | PROCESS FOR THE EXTRACTION OF FURANIC COMPOUNDS AND POLYHYDROXYL FATTY ALCOHOLS FROM LAWYER, COMPOSITION BASED ON AND USE OF THESE COMPOUNDS IN THERAPEUTICS, COSMETICS AND FOOD |
-
2002
- 2002-07-30 FR FR0209666A patent/FR2843027B1/en not_active Expired - Lifetime
-
2003
- 2003-07-28 CN CNA038232499A patent/CN1691953A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105392873A (en) * | 2013-06-04 | 2016-03-09 | 普瓦图-夏朗德萨姆瓦拉格罗可再生碳公司 | Processes for selective extraction of unsaponifiable materials from renewable raw materials by liquid-liquid extraction in the presence of a cosolvent |
| CN104172171A (en) * | 2014-08-27 | 2014-12-03 | 金湘范 | Raw extract of leafy plants as well as preparation method and application |
| CN104172171B (en) * | 2014-08-27 | 2016-08-17 | 金湘范 | A kind of former dew of leaf type plant, preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2843027B1 (en) | 2005-12-30 |
| FR2843027A1 (en) | 2004-02-06 |
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