CN1687087A - Method for preparing Rosuvastain and its intermediate - Google Patents
Method for preparing Rosuvastain and its intermediate Download PDFInfo
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- CN1687087A CN1687087A CN 200510069557 CN200510069557A CN1687087A CN 1687087 A CN1687087 A CN 1687087A CN 200510069557 CN200510069557 CN 200510069557 CN 200510069557 A CN200510069557 A CN 200510069557A CN 1687087 A CN1687087 A CN 1687087A
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Abstract
The present invention relates to a preparation method of medicine for reducing blood-lipid-Reshufatadine compound. Said method uses side chain aldehyde compound and triphenyl phosphorus ylide reagent compound and makes them undergo the condensation reaction so as to obtain Reshufatadine compound with high yield. Said invention also provides its key intermediate compound.
Description
Invention field
The present invention relates to organic chemistry filed, particularly, the present invention relates to the new preparation method of a kind of Rosuvastatin and intermediate thereof.
Background technology
Rosuvastatin (ROSUVASTATIN) is a kind of inhibitor of novel HMG-CoA reductase enzyme, the medicine of blood fat reducing efficiently, because it has the advantage of high-efficiency low-toxicity side effect, and extremely people's favor, so this medicine holds out broad prospects.
This compound and preparation method thereof is disclosed among the European patent EP 0521471A.The characteristics of its preparation method are that the pyrimidine parent nucleus is obtained polysubstituted formaldehyde, in addition, chiral side chain are synthesized the phosphine ester, obtain the Rosuvastatin skeleton by Wei Tixi (Wittig) reaction condensation again.Its crucial synthesis step is as follows:
The inventor finds by the synthetic method of research Rosuvastatin: the phosphine ester that obtains according to the method for patent not only on synthetic difficulty big, cost height, but also use toxicity such as trimethyl phosphite and pollute bigger raw material; In addition, adopt the yield of this method condensation lower, the yield of bibliographical information has only about 60-70%.The concentrate on studies synthetic method of Rosuvastain fourth of the inventor, chiral side chain is made polysubstituted formaldehyde, simultaneously parent nucleus is made phosphine leaf Reed (Ylide) intermediate, obtain the Rosuvastatin skeleton by the reaction condensation of dimension ladder west again, obtain the novel method in a kind of synthesizing rosuvastatin spit of fland, finish the present invention thus.
Summary of the invention
Therefore, the purpose of this invention is to provide a kind of method for preparing the midbody compound of Rosuvastatin;
Another object of the present invention has provided a kind of midbody compound for preparing Rosuvastatin;
Another object of the present invention has provided a kind of method for preparing the Rosuvastatin compound.
Method of the present invention is with 4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methyl sulphonyl-amido)-pyrimidine-5-base-methyl alcohol (compound (1), the preparation of this compound is referring to EP0521471A)
Be raw material, obtain compound (2) through bromination; Becoming phosphonium salt to obtain compound (3) again is parent nucleus compound; Compound (3) carries out the reaction of Wei Xi ladder with side chain aldehyde cpd (4) (according to the embodiment 6 methods preparation of US4970313A) and obtains compound (5), i.e. Rosuvastatin skeleton; At last compound (5) is carried out deprotection, hydrolysis, salt-forming reaction and obtain the Rosuvastatin calcium salt.Concrete synthetic route is as follows:
Compound (1) compound (2)
Compound (2) compound (3)
Compound (3) compound (5)
Compound (5) compound (6)
Among the preparation method of Rosuvastatin of the present invention, the midbody compound (3) in the crucial condensation reaction is a new compound, and this compound has also constituted key character of the present invention.
The method that the present invention prepares Rosuvastatin also has following characteristics: (1) uses triphenyl phosphorus that parent nucleus is made the triphenylphosphine salt compound, avoids using tricresyl phosphite alkyl (or aryl) ester of high poison, has both made things convenient for explained hereafter, helps environmental protection again; (2) yield of committed step condensation reaction of the present invention is up to 78.3%, and product quality is very high, has improved productive rate, has reduced cost.The present invention has improved the total recovery of preparation Rosuvastatin significantly by taking above-mentioned technique means.
Further specify the present invention below by embodiment.The preparation method who it should be understood that the embodiment of the invention is only used for illustrating the present invention, rather than limitation of the present invention, and the simple modifications to preparation method of the present invention under design prerequisite of the present invention all belongs to the scope of protection of present invention.
Embodiment
Synthetic (preparation of compound (2)) of embodiment 1:4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methyl sulphonyl-amido)-pyrimidine-5-base-a monobromethane
In 2 liters four-hole boiling flask, drop into 143.3g compound (1) (its preparation method is referring to EP0521471A), add 780ml methylene dichloride stirring and dissolving, add 780ml toluene.Restir 10 minutes.Be added dropwise to the 63ml phosphorus tribromide, controlled temperature<0 ℃, drip finish after, 0 ℃ of following insulation reaction 3 hours.In the 1200ml saturated sodium bicarbonate solution that the reaction solution impouring is prepared, stirred 10 minutes, standing demix extracts organic layer.With the 350ml water washing once, add the 180g anhydrous magnesium sulfate drying more than 5 hours, filter, concentrating under reduced pressure adds the 300ml normal hexane, and the stirring at room crystallization is filtered, and oven dry obtains white solid 261.8g, yield 84%.
The preparation (preparation of compound (3)) of embodiment 2:4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methyl sulphonyl-amido)-pyrimidine-5-base-monobromethane triphenylphosphine salt
Room temperature reaction is dissolved in 261.8g compound (2) in the 1730ml toluene.Room temperature slowly drips the toluene solution 420ml that contains the 130g triphenyl phosphorus, adds in about 5 hours, and stirring is spent the night.Centrifuging, solid are pulled an oar once with 760ml toluene again, centrifuging, and oven dry obtains white solid 284.4g (compound (3)), yield 81%.
Embodiment 3:(E)-4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methyl sulphonyl-amido)-pyrimidine-5-base-(3R, 5S)-2,2-dimethyl-1, the preparation of 3-dioxolane-4-tert.-butyl acetate (preparation of compound (5))
In the four-hole boiling flask of 500ml, add 50g compound (3), 18.5g side chain aldehyde (4) (according to the embodiment 6 methods preparation of US4970313A), 400ml tetrahydrofuran (THF), be heated to 70 ℃, stirred and closed dissolving.Stop heating, add 60% sodium hydride 2.75g.Behind the stirring reaction 15 minutes, termination reaction in the reaction solution impouring frozen water.Add 950ml ethyl acetate extraction organic layer,, add the 70g anhydrous sodium sulfate drying more than 5 hours with 200ml water washing twice.Filter, be evaporated to dried.Add 480ml ethanol and be as cold as-5 ℃ of crystallizations 6 hours.Filter, drain and obtain crude product, with 360ml ethanol heating for dissolving recrystallization.Filter, oven dry obtains white solid (being compound (5)) 32.4g, HPLC purity 98.8%, yield 78.3%.
Embodiment 5:7-(4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methyl sulphonyl-amido)-pyrimidine-5-yl)-(3R, 5S)-preparation (preparation of compound (6)) of 6-(E)-Semi-Heptanoic Acid Calcium Salt
In reaction flask, drop into the THF stirring and dissolving of 32.4g compound (5) and 324ml, add 324ml methyl alcohol.Be warmed up to 35 ℃, add 2M dilute hydrochloric acid 16ml, stirring reaction.After about 5 hours, TLC detects raw material and disappears substantially.Be added dropwise to the sodium hydroxide solution 56ml of 1M, reacted 60 minutes, concentrating under reduced pressure removes methyl alcohol, adds pure water and uncle's butyl ether, extracts twice.Cross the elimination insolubles.Be cooled to 20 ℃, be added dropwise to 0.5g/ml calcium acetate solution 6ml, stirred 30 minutes, filter, wash twice.Dry, pulverizing obtain Rosuvastatin half calcium salt (compound (6)) finished product 25.2g.
Claims (4)
1. preparation method who prepares intermediate formula (3) compound of Rosuvastatin comprises formula (2) compound and triphenyl phosphorus reaction:
3. a method for preparing the Rosuvastatin compound comprises the following steps:
Step 1: formula (2) compound and triphenyl phosphorus prepared in reaction are obtained formula (3) compound:
Step (2): compound (3) and side chain aldehyde cpd (4) condensation under alkaline condition are obtained compound (5):
Step 3: with compound (5) successively through in deprotection under the acidic conditions, hydrolysis and obtain Rosuvastatin half calcium salt (6) under alkaline condition with the calcium acetate salt-forming reaction:
Compound (5) compound (6).
4. the compound below a kind (3) compound:
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Cited By (16)
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WO2010047296A1 (en) | 2008-10-20 | 2010-04-29 | 株式会社カネカ | NOVEL PYRIMIDINE DERIVATIVE AND METHOD FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR INTERMEDIATE |
CN101376647B (en) * | 2007-08-31 | 2010-12-08 | 中山奕安泰医药科技有限公司 | Method for synthesizing rosuvastatin intermediate and rosuvastatin |
CN102311457A (en) * | 2011-09-16 | 2012-01-11 | 苏州莱克施德药业有限公司 | Preparation method of rosuvastatin |
CN102358747A (en) * | 2011-08-30 | 2012-02-22 | 浙江宏元药业有限公司 | Rosuvastatin calcium intermediate and method for preparing rosuvastatin calcium intermediate and rosuvastatin calcium |
CN103113357A (en) * | 2013-03-12 | 2013-05-22 | 江苏阿尔法药业有限公司 | Preparation method of statin intermediate and derivatives thereof |
CN103113356A (en) * | 2013-03-07 | 2013-05-22 | 上海现代制药股份有限公司 | Method for preparing rosuvastatin calcium intermediate |
CN103483269A (en) * | 2012-06-13 | 2014-01-01 | 上海迪赛诺药业有限公司 | Preparation methods for rosuvastatin calcium and intermediates thereof |
CN103570762A (en) * | 2013-11-25 | 2014-02-12 | 复旦大学 | Preparation method of ((4-p-fluorophenyl-6-isopropyl-2-(N-methylmethanesulfonamide)-5-pyridyl) methyl)triphenyl phosphonium salt |
CN103864698A (en) * | 2014-02-27 | 2014-06-18 | 常州金隆生物医药有限公司 | Method for preparing rosuvastatin calcium |
CN103936680A (en) * | 2014-04-18 | 2014-07-23 | 润泽制药(苏州)有限公司 | Preparation method of known impurities of rosuvastatin |
CN104321320A (en) * | 2013-02-20 | 2015-01-28 | 意大利合成制造有限公司 | Convenient process for the preparation of statins |
CN105017158A (en) * | 2015-07-31 | 2015-11-04 | 江西富祥药业股份有限公司 | Preparation method of cis-rosuvastatin calcium impurity |
CN106674281A (en) * | 2016-12-31 | 2017-05-17 | 安徽美诺华药物化学有限公司 | Rosuvastatin intermediate compound and preparation method and application thereof |
CN106854201A (en) * | 2017-01-03 | 2017-06-16 | 浙江海洲制药有限公司 | A kind of purification process of rosuvastain calcium intermediate |
CN109824723A (en) * | 2017-11-23 | 2019-05-31 | 上虞京新药业有限公司 | A kind of rosuvastain calcium intermediate novel crystal forms |
CN109824724A (en) * | 2017-11-23 | 2019-05-31 | 上虞京新药业有限公司 | A kind of preparation method of rosuvastain calcium intermediate |
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JP2008539278A (en) | 2006-09-18 | 2008-11-13 | テバ ファーマシューティカル インダストリーズ リミティド | Crystalline rosuvastatin calcium |
KR20090033183A (en) | 2007-04-18 | 2009-04-01 | 테바 파마슈티컬 인더스트리즈 리미티드 | Rosuvastatin intermediates and process for the preparation of rosuvastatin |
US7884226B2 (en) | 2007-07-12 | 2011-02-08 | Teva Pharmaceutical Industries, Ltd. | Purification of rosuvatatin intermediate by thin film evaporation and chemical method |
Family Cites Families (2)
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JP2648897B2 (en) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | Pyrimidine derivatives |
ATE501126T1 (en) * | 2002-12-10 | 2011-03-15 | Ranbaxy Lab Ltd | METHOD FOR PRODUCING ROSUVASTATIN |
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WO2010047296A1 (en) | 2008-10-20 | 2010-04-29 | 株式会社カネカ | NOVEL PYRIMIDINE DERIVATIVE AND METHOD FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR INTERMEDIATE |
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CN103483269A (en) * | 2012-06-13 | 2014-01-01 | 上海迪赛诺药业有限公司 | Preparation methods for rosuvastatin calcium and intermediates thereof |
CN103483269B (en) * | 2012-06-13 | 2016-04-27 | 上海迪赛诺药业有限公司 | The preparation method of rosuvastain calcium and intermediate thereof |
CN104321320A (en) * | 2013-02-20 | 2015-01-28 | 意大利合成制造有限公司 | Convenient process for the preparation of statins |
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CN106854201A (en) * | 2017-01-03 | 2017-06-16 | 浙江海洲制药有限公司 | A kind of purification process of rosuvastain calcium intermediate |
CN106854201B (en) * | 2017-01-03 | 2019-12-06 | 浙江海洲制药有限公司 | Purification method of rosuvastatin calcium intermediate |
CN109824723A (en) * | 2017-11-23 | 2019-05-31 | 上虞京新药业有限公司 | A kind of rosuvastain calcium intermediate novel crystal forms |
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