CN1679517A - Thin-membrane coating material of enteric coated water soluble medicine and preparation thereof - Google Patents
Thin-membrane coating material of enteric coated water soluble medicine and preparation thereof Download PDFInfo
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- CN1679517A CN1679517A CN 200510042004 CN200510042004A CN1679517A CN 1679517 A CN1679517 A CN 1679517A CN 200510042004 CN200510042004 CN 200510042004 CN 200510042004 A CN200510042004 A CN 200510042004A CN 1679517 A CN1679517 A CN 1679517A
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- coating material
- thin
- water soluble
- enteric coated
- soluble medicine
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Abstract
A coating material for enteric water-soluble medicine is proportionally prepared from methylacrylic acid, methyl methyacrylate, isooctyl mercaptoacetate, OP-10, sodium lauryl sulfate and ammonium persulfate through mixing OP-10, sodium laurylsulfate, ammonium persulfate and deionized water, heating, adding isooctyl mercaptoacetate, methyl acrylic acid and methyl methylacrylate, holding the temp for 1 hr, and cooling.
Description
Technical field: the present invention relates to thin-membrane coating material of enteric coated water soluble medicine and preparation method thereof field.Particularly relate to methacrylic acid and methyl methacrylate is thin-membrane coating material of enteric coated water soluble medicine and preparation method thereof the field of copolymer.
Background technology: present thin-membrane coating material of enteric coated water soluble medicine, be generally methacrylic acid and methylmethacrylate copolymer, also useful propylene ethyl ester or butyl acrylate replace methyl methacrylate as comonomer, but this coating material production process will be used organic solvent, exist environmental pollution, have a strong impact on the healthy of staff, and production procedure is long, production cost is high, is difficult to apply.
Summary of the invention: purpose of the present invention, thin-membrane coating material of enteric coated water soluble medicine of study exactly and a kind ofly do not adopt organic solvent, production procedure is short, cost is low, applies easily and preparation method thereof.
In order to realize purpose of the present invention, it is copolymer that the inventor adopts methacrylic acid and methyl methacrylate, Ammonium persulfate. or potassium peroxydisulfate are initiator, OP-10 and sodium lauryl sulphate are compound newborn mixture, the different monooctyl ester of mercapto is a molecular weight regulator, adopt emulsion polymerisation process to prepare thin-membrane coating material of enteric coated water soluble medicine, it is methacrylic acid, the methylmethacrylate copolymer emulsion, this emulsion can be directly used in the film coating of enteric medicine, also available traditional spray drying method is made powder, uses guanidine-acetic acid in aqueous or oiliness controlled release drug coating.Below the present invention is described in detail:
The composition of thin-membrane coating material of enteric coated water soluble medicine is:
(quality %) component
13.87-18.97 methacrylic acid
11.03-16.13 methyl methacrylate
0.7-0.9 isooctyl thioglycolate
0.4-0.6 OP-10
0.2-0.3 sodium lauryl sulphate
0.1-0.2 Ammonium persulfate.
The deionized water of aequum.
The outfit method of thin-membrane coating material of enteric coated water soluble medicine of the present invention:
(a) emulsifier op-10, sodium lauryl sulphate, Ammonium persulfate. and deionized water are mixed, place reaction bulb, be warming up to 80 degree Celsius,
(b) isooctyl thioglycolate, monomer methacrylic acid and methyl methacrylate mixing are added drop-wise in the reaction bulb, the time of dropping is three hours, after dripping off, is incubated one hour, the cooling reactant liquor, and discharging obtains the stable polymer emulsion.
The physical and chemical index of thin-membrane coating material of enteric coated water soluble medicine of the present invention:
Solid content: 30% (up and down 1)
Ignition residue :≤0.12%
Heavy metal: less than 10/1000000ths
Arsenic salt :≤0.0002
Method of testing:
Solid content is measured according to GB1725-79 solids coatings algoscopy.
Other index is measured according to two acrylic resin 11 appendix of Pharmacopoeia of People's Republic of China (version in 2000).
The specific embodiment:
Example 1:
(quality %) component
13.87 methacrylic acid
11.03 methyl methacrylate
0.7 isooctyl thioglycolate
0.4 OP-10
0.2 sodium lauryl sulphate
0.1 Ammonium persulfate.
The deionized water of aequum.
Example 2:
(quality %) component
15.20 methacrylic acid
14.12 methyl methacrylate
0.8 isooctyl thioglycolate
0.5 OP-10
0.25 sodium lauryl sulphate
0.14 Ammonium persulfate.
The deionized water of aequum.
Example 3:
(quality %) component
18.97 methacrylic acid
16.13 methyl methacrylate
0.9 isooctyl thioglycolate
0.6 OP-10
0.3 sodium lauryl sulphate
0.2 persulfuric acid 2 Ammonium persulfate .s
The deionized water of aequum.
Example 4:
In one 2 liters reaction bulb, add the deionized water of 682.1 grams, the Ammonium persulfate. of 1.8 grams, 5.5 the gram OP-10,2.8 the gram sodium lauryl sulphates, stir and be warming up to 80 degree Celsius, methyl methacrylate with 161.3 grams, 138.7 the methacrylic acid of gram, 7.8 gram isooctyl thioglycolates are incorporated in the Dropping funnel, behind the mix homogeneously, beginning at the uniform velocity drips, drip China in three hours, insulation reaction is one hour again, cooling discharging.
Example 5:
The deionized water that in one 2 liters reaction bulb, adds 682.1 grams, 1.8 gram Ammonium persulfate .s, 5.5 gram OP-10,2.8 the sodium lauryl sulphate of gram, stir and be warming up to 80 degree Celsius, with 110.3 gram methyl methacrylates, 189.7 gram methacrylic acids, 7.8 the gram isooctyl thioglycolate is incorporated in the Dropping funnel, behind the mix homogeneously, beginning at the uniform velocity drips, and drips China after three hours, insulation reaction is one hour again, cooling discharging.
Claims (2)
1 thin-membrane coating material of enteric coated water soluble medicine is characterized in that component and content (quality %) are
13.87-18.97 methacrylic acid
11.03-16.13 methyl methacrylate
0.7-0.9 isooctyl thioglycolate
0.4-0.6 OP-10 emulsifying agent
0.2-0.3 sodium lauryl sulphate
0.1-0.2 Ammonium persulfate.
The deionized water of aequum.
The preparation method of 2 thin-membrane coating material of enteric coated water soluble medicine is characterized in that:
(a) component and the content that will say by claim 1 places polyoxyethylene nonylphenol ether, sodium lauryl sulphate, deionized water reaction bulb to mix, and is warming up to 80 degree Celsius,
(b) component and the content of saying by claim isooctyl thioglycolate, methacrylic acid, methyl methacrylate mix homogeneously, drops in the reaction bulb, dropwises in three hours, is incubated one hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510042004 CN1679517A (en) | 2005-01-07 | 2005-01-07 | Thin-membrane coating material of enteric coated water soluble medicine and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510042004 CN1679517A (en) | 2005-01-07 | 2005-01-07 | Thin-membrane coating material of enteric coated water soluble medicine and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1679517A true CN1679517A (en) | 2005-10-12 |
Family
ID=35066545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510042004 Pending CN1679517A (en) | 2005-01-07 | 2005-01-07 | Thin-membrane coating material of enteric coated water soluble medicine and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1679517A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100465201C (en) * | 2007-04-25 | 2009-03-04 | 上海大学 | Method for preparing water-soluble resin latex in acrylic acid series in use for intestine soluble coating material for medication |
| CN102127184A (en) * | 2010-12-24 | 2011-07-20 | 张晓梅 | Enteric medicinal coating polyacrylic resin emulsion with internal plasticization function and preparation method thereof |
| CN105085397A (en) * | 2014-05-30 | 2015-11-25 | 上海特化医药科技有限公司 | Aripiprazole semi-ethanolate with new crystal form, and preparation method and use thereof |
-
2005
- 2005-01-07 CN CN 200510042004 patent/CN1679517A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100465201C (en) * | 2007-04-25 | 2009-03-04 | 上海大学 | Method for preparing water-soluble resin latex in acrylic acid series in use for intestine soluble coating material for medication |
| CN102127184A (en) * | 2010-12-24 | 2011-07-20 | 张晓梅 | Enteric medicinal coating polyacrylic resin emulsion with internal plasticization function and preparation method thereof |
| CN102127184B (en) * | 2010-12-24 | 2013-07-10 | 张晓梅 | Enteric medicinal coating polyacrylic resin emulsion with internal plasticization function and preparation method thereof |
| CN105085397A (en) * | 2014-05-30 | 2015-11-25 | 上海特化医药科技有限公司 | Aripiprazole semi-ethanolate with new crystal form, and preparation method and use thereof |
| CN105085397B (en) * | 2014-05-30 | 2018-02-09 | 上海特化医药科技有限公司 | The ethanolates novel crystal forms of Aripiprazole half, preparation method and the usage |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |