CN1663615A - Fructose injection of antibiotic medicine - Google Patents
Fructose injection of antibiotic medicine Download PDFInfo
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- CN1663615A CN1663615A CN 200410008137 CN200410008137A CN1663615A CN 1663615 A CN1663615 A CN 1663615A CN 200410008137 CN200410008137 CN 200410008137 CN 200410008137 A CN200410008137 A CN 200410008137A CN 1663615 A CN1663615 A CN 1663615A
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Abstract
Disclosed is a fructose injection of antibiotic medicine comprising antibiotics, fructose syrup and water, or right amount of adjunct, wherein the antibiotics include Gatifloxacin, Levofloxacin, Ofloxacin, ciprofloxacin, Pazufloxacin, fleraxacin, Sparfloxacin, moxifloxacin, pefloxacin, Rufloxacin, Lomefloxacin, Norfloxacin, Azithromycin, telithromycin, Ornidazole, Secnidazole, Tinidazole, Metronidazole, Clindamycin, Lincomycin, Fluconazole, Etimicin, Netilmicin, Amikacin and their medicinal acid addition salts, esters and derivatives.
Description
Technical fieldThe invention belongs to medical technology neck city, relate to the fructose injection injection medicine of a series of antibiotic medicines.
Background technologyInjection is a class I liquid I injection, and medicine directly enters in human vas, tissue or the organ with liquid form, and drug absorption is fast, and effect is rapid, and being very suitable for rescuing critical patient and patient should not use under the case of oral administration.
Antibiotic is the medicine of clinical widely used anti-microbial effect, especially antibiotic injection drug, in clinical use, usually together inject use as a kind of carrier and antibiotic medicine with glucose or sodium chloride solution, as levofloxacin lactate glucose injection, ornidazole sodium chloride injection etc.Glucose in the injection and sodium chloride can also be corrected the disorder that the interior power and water of body is separated matter except having the effect of regulating osmotic pressure, regulate the acid-base balance of body fluid, and glucose can also replenish necessary nutrition, heat and moisture content.
For the medicine that uses with injection system, especially antibiotics glucose injection medicine, glucose solution is as a kind of pharmaceutical carrier, be oxidized to carbon dioxide and water in vivo, and energize simultaneously, or store the effect that detoxifcation is arranged, protects the liver with the form of glycogen, this is a kind of good rehabilitation support for the patient, helps the recovery of body function and the toxic and side effects of minimizing medicine; But since glucose in vivo metabolism need consume insulin, should not use for diabetics and impaired glucose tolerance person, reduced the scope of its use to a great extent.
The purpose of this invention is to provide a series of antibiotic injection medicines, make the carrier composition that wherein is used to regulate osmotic pressure have pharmacological effect, and diabetics and impaired glucose tolerance person all can use safely as glucose.
Summary of the inventionIn order to achieve the above object, the present invention adopts that antibiotic is made with the fructose soln is the injection of carrier.
Fructose is the isomer of glucose, has the optics levorotation, be called levulose again, its pharmacological action is identical substantially with glucose, the effect that has direct supply heat, replenishes body fluid and nutrition whole body, and fructose to be converted into hepatic glycogen faster than glucose, and can under no insulin situation, be metabolized to glycogen, therefore than the easier absorption of glucose, utilization, preferably to patient's energize, the added body liquor ratio glucose of diabetes, heart disease, abnormal liver function.
The antibiotic fructose injection of the present invention is the antibiotic medicine of the liquid dosage form of injection use, and it is formed and comprises antibiotic, fructose and three kinds of compositions of water at least.Antibiotic is its principal agent composition; Fructose is to be used for regulating the osmotic pressure of injection and to have the heat of providing and complementary pharmacological action such as nutrition; Water has compositions such as dissolving antibiotic and fructose as solvent, keeps the effect of liquid dosage form.
Antibiotic is a total notion title, not all antibiotic medicine fructose injection that all suits to be mixed with.The antibiotic fructose injection of the present invention, antibiotic is as the principal agent composition, and it comprises following 25 kinds of antibiotic medicines: Gatifloxacin, levofloxacin, ofloxacin, ciprofloxacin, Pazufloxacin, fleroxacin, Sparfloxacin, Moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, cadrofloxacin, azithromycin, Ketek, ornidazole, Saikexiaozuo, tinidazole, metronidazole, clindamycin, lincomycin, fluconazol, etimicin, netilmicin, amikacin.
Should be noted that, above the antibiotic medicine also comprise their separately pharmaceutically acceptable acid addition salts, carboxylate, derivant etc., for example levofloxacin just has various forms of addition hydrochlorates, as levofloxacin lactate, levofloxacin hydrochloride, Levofloxacin M. S. A or the like; The addition salts Pazufloxacin Mesilate of Pazufloxacin its methanesulfonic acid commonly used; For example clindamycin has forms such as clindamycin phosphate, Clindamycin Hydrochloride, clindamycin hydrochloride palmitate again; Zitromax have forms such as lactobionic acid azithromycin, Azithromycin Sulfate.These all are that those skilled in the art are familiar with, and give unnecessary details no longer one by one at this.
What those skilled in the art were appreciated that is, because the different in kind of each antibiotic medicine, in its fructose injection, safe, effectively and each component stable in order to ensure injection, character according to different antibiotic medicines, can also add other suitable material, these materials are referred to as " additives ".Additives can be divided into following a few class:
The pH value regulator: the pH value that is used for regulating injection is for example often selected hydrochloric acid, citric acid, potassium hydroxide (sodium), sodium dihydrogen phosphate, sodium hydrogen phosphate etc. for use with stability that increases medicine and the absorption of accelerating medicinal liquid;
Solubilizing agent and cosolvent: the purpose of interpolation is in order to increase the dissolubility of principal agent in aqueous solvent, treats required purpose to reach smelting, and for example commonly used have Tween-80, glycerol, an ethanol etc.;
Antioxidant: the Reducing agent that is the easy oxidation of a class, when antioxidant and medicine existed simultaneously, anti-giving birth at first took place with oxygen in antioxidant, thereby the protection medicine exempts from oxidation, guaranteeing the stable of medicine, for example commonly used have sodium sulfite, sodium sulfite, vitamin C, sodium pyrosulfite, a thiourea etc.;
Metal chelating agent: be used for medicinal liquid in trace metal ion generate stable complex, avoid the catalytic action of metal ion to the pharmaceutical compositions oxidation, for example often select ethylenediaminetetraacetic acid, disodiumedetate etc. for use;
Noble gas: be used for replacing the air in medicinal liquid and the packing container, avoid the principal agent oxidation, for example often select nitrogen, carbon dioxide for use;
Suspensoid and emulsifying agent: the purpose of interpolation is dispersibility and the stability that height is arranged for the principal agent composition that makes injection, and for example commonly used have soybean phosphatide, lecithin, a Tween-80 etc.;
Analgesic: the purpose of interpolation be for alleviate when using injection owing to medicine itself to the pain that stimulation or other reason of body generation causes, for example often select lidocaine hydrochloride, procaine hydrochloride, chlorobutanol etc. for use.
More than these additives be not the composition that must use, but select to use according to the character of prepared antibiotic fructose injection, its select for use with using method all be well known to those skilled in the art.
Preparation technology's flow process of the antibiotic fructose injection of the present invention is similar to glucose injection of the prior art or sodium chloride injection, basic operating procedure is to prepare fructose water solution earlier, use activated carbon adsorption thermal source, decolouring after regulating pH value and adding other additives, add antibiotic medicine and additives behind the filtering active carbon, dissolving, fine straining, filling and sealing, sterilization gets final product.For various antibiotic kind; the preparation process of its fructose injection can be different; but the antibiotic fructose injection of producing with any preparation method, technological process no matter; as long as contain antibiotic, fructose, water and additives in its finished product, all belong to the protection domain of the technology of the present invention.
Antibiotic is made as fructose injection, except easy to use, rapid-action advantage, compares the injection of glucose, be more suitable for diabetes, heart disease, hepatopath's use, enlarged its scope of application with injection.
The specific embodimentTwo embodiment with following further illustrate the composition of antibiotic fructose injection of the present invention by its preparation process, but do not represent the embodiment limitation of the present invention.
Embodiment 1. lomefloxacin hydrochloride fructose injections
Get fructose and dissolve fully an amount of the adding in an amount of water for injection, add the needle-use activated carbon of appropriate amount again, stir evenly, regulate pH value 4～4.5 with hydrochloric acid solution, 90 ℃ are incubated 30 minutes, filter while hot and remove active carbon; Other gets the appropriate hydrochloric acid lomefloxacin and adds in the above-mentioned fructose filtrate, adds to the full amount of water for injection, and stirs evenly, and the fine straining potting in 115 ℃ of pressure sterilizings 30 minutes, detects check, and packing gets final product.
In above-mentioned preparation process, active carbon is used for adsorbing pyrogen and decolouring, and active carbon is not the composition of injection; In addition, the inventory of control lomefloxacin hydrochloride and fructose can make the injection of variable concentrations, for example can be made into every 100ml and contains lomefloxacin 0.2 gram, the injection of fructose 5 grams.
The composition of this lomefloxacin hydrochloride fructose injection is: lomefloxacin hydrochloride, fructose, hydrochloric acid and water, wherein hydrochloric acid is additives, plays the effect of regulating pH value.
Embodiment 2. ornidazole fructose injections
After taking by weighing the about 900ml dissolving of ornidazole 5 gram adding waters for injection, add 50 gram fructose, whisk to CL, transfer about pH value to 4.5 with dilute hydrochloric acid, add 0.05% needle-use activated carbon, insulation is 15 minutes about 50 ℃, decarbonization filtering while hot, add the injection water to 1000ml, after the content of mensuration solution and pH value are qualified, 0.45 micron microporous filter membrane fine straining of reuse, the inflated with nitrogen embedding is in the 100ml infusion bottle, through 115 ℃ of pressure sterilizings 30 minutes, promptly get every bottle and contain the 0.5g ornidazole, the injection of 5.0g fructose.
The composition of this ornidazole fructose injection is: ornidazole, and fructose, hydrochloric acid, the nitrogen G﹠W, wherein hydrochloric acid and nitrogen are additives, are respectively pH value regulator and protective gas.
Claims (4)
1. antibiotic fructose injection is characterized in that it is made up of a kind of antibiotic, fructose and water, can also contain suitable additives.
2. antibiotic fructose injection according to claim 1 is characterized in that antibiotic comprises Gatifloxacin, levofloxacin, ofloxacin, ciprofloxacin, Pazufloxacin, fleroxacin, Sparfloxacin, Moxifloxacin, pefloxacin, rufloxacin, lomefloxacin, norfloxacin, cadrofloxacin, azithromycin, Ketek, ornidazole, Saikexiaozuo, tinidazole, metronidazole, clindamycin, lincomycin, fluconazol, etimicin, netilmicin, amikacin.
3. antibiotic fructose injection according to claim 1 is characterized in that additives comprise pH value regulator, solubilizing agent and cosolvent, antioxidant, metal chelating agent, noble gas, suspensoid and emulsifying agent, analgesic.
4. according to claim 1,2 described antibiotic fructose injections, it is characterized in that antibiotic comprises its pharmaceutically acceptable acid addition salts, carboxylate, derivant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410008137 CN1663615A (en) | 2004-03-05 | 2004-03-05 | Fructose injection of antibiotic medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410008137 CN1663615A (en) | 2004-03-05 | 2004-03-05 | Fructose injection of antibiotic medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1663615A true CN1663615A (en) | 2005-09-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410008137 Pending CN1663615A (en) | 2004-03-05 | 2004-03-05 | Fructose injection of antibiotic medicine |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100415212C (en) * | 2006-07-21 | 2008-09-03 | 哈药集团制药总厂 | An oral preparation containing caderofloxacin lactate |
| CN100453068C (en) * | 2006-07-21 | 2009-01-21 | 哈药集团制药总厂 | Injection containing caderfloxacin lactate |
| CN101234116B (en) * | 2006-07-21 | 2010-11-24 | 哈药集团制药总厂 | Powder needle injection containing caderofloxacin lactate |
| CN102018960A (en) * | 2010-12-01 | 2011-04-20 | 安徽省皖北药业股份有限公司 | Method for keeping quality stability of clindamycin phosphate injection |
| CN102078296A (en) * | 2010-12-22 | 2011-06-01 | 蚌埠丰原医药科技发展有限公司 | Reserpine fructose injection and preparation method thereof |
| CN102631315A (en) * | 2012-04-09 | 2012-08-15 | 南阳普康药业有限公司 | Method for preparing clindamycin hydrochloride injection |
| CN102048685B (en) * | 2009-11-02 | 2012-10-17 | 海口市制药厂有限公司 | Pefloxacin mesylate injection and preparation method and application thereof |
| CN102038638B (en) * | 2009-10-26 | 2012-12-26 | 海口市制药厂有限公司 | Clindamycin hydrochloride injection and preparation method thereof |
| CN103830164A (en) * | 2012-11-20 | 2014-06-04 | 北大方正集团有限公司 | Moxifloxacin hydrochloride injection liquid and preparation method thereof |
-
2004
- 2004-03-05 CN CN 200410008137 patent/CN1663615A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100415212C (en) * | 2006-07-21 | 2008-09-03 | 哈药集团制药总厂 | An oral preparation containing caderofloxacin lactate |
| CN100453068C (en) * | 2006-07-21 | 2009-01-21 | 哈药集团制药总厂 | Injection containing caderfloxacin lactate |
| CN101234116B (en) * | 2006-07-21 | 2010-11-24 | 哈药集团制药总厂 | Powder needle injection containing caderofloxacin lactate |
| CN102038638B (en) * | 2009-10-26 | 2012-12-26 | 海口市制药厂有限公司 | Clindamycin hydrochloride injection and preparation method thereof |
| CN102048685B (en) * | 2009-11-02 | 2012-10-17 | 海口市制药厂有限公司 | Pefloxacin mesylate injection and preparation method and application thereof |
| CN102018960A (en) * | 2010-12-01 | 2011-04-20 | 安徽省皖北药业股份有限公司 | Method for keeping quality stability of clindamycin phosphate injection |
| CN102078296A (en) * | 2010-12-22 | 2011-06-01 | 蚌埠丰原医药科技发展有限公司 | Reserpine fructose injection and preparation method thereof |
| CN102631315A (en) * | 2012-04-09 | 2012-08-15 | 南阳普康药业有限公司 | Method for preparing clindamycin hydrochloride injection |
| CN103830164A (en) * | 2012-11-20 | 2014-06-04 | 北大方正集团有限公司 | Moxifloxacin hydrochloride injection liquid and preparation method thereof |
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