CN1663534A - Intervention type tissue hardness supersonic obtaining method and intervening supersonic hardness-detecting device - Google Patents
Intervention type tissue hardness supersonic obtaining method and intervening supersonic hardness-detecting device Download PDFInfo
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- CN1663534A CN1663534A CN 200510020378 CN200510020378A CN1663534A CN 1663534 A CN1663534 A CN 1663534A CN 200510020378 CN200510020378 CN 200510020378 CN 200510020378 A CN200510020378 A CN 200510020378A CN 1663534 A CN1663534 A CN 1663534A
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Abstract
The invention relates to one kind of tissue hardness acquisition method by intervenient ultrasound and comprises building ultrasonic transducer supported by intervenient duct and pressure sensor structure. By intervenient duct operated out of body, forcing pressure to detected tissue through aqueous capsule, recordings continually pressure and the echo signal variety received by ultrasonic transducer, and displaying variety image of tissue thickness by M type ultrasound cardiogram pattern; measuring the change values of pressure and thickness; charactering tissue hardness by pressure value and change value of thickness obtained, and computing elastic modulus. Intervenient ultrasound hardness detector mentioned comprises ultrasound hardness detecting duct and host computer, liquid sac is fixed on the head end of duct, and the ultrasonic transducer and pressure sensor following fixed; power line and signal line in duct connect to main computer. By this invention people can obtain directly tissue hardness for passive deforming ability, elastic modulus and other basic physical quantity, which brings direct and reliable information to scientific study and detecting tissue hardness in clinic.
Description
Technical field
The present invention relates to human body physical parameter acquisition methods and diagnostic ultrasonic equipment, relate to the interventional minimally-invasive technology for information acquisition simultaneously.Be used for obtaining of cardiac muscle, trunk and other human body deep viscera tissue hardness number.Be a kind of conduit interventional technique that utilizes, obtain and analyze the stress-strain relation organized in human or animal's live body deep, thereby directly obtain the method for tissue elastic parameter and attribute.The information of being obtained is of value to assists medical research and clinical diagnosis.
Background technology:
The hardness of biological tissue is the whether important indicator of pathological changes of characterizing tissues, judges that cardiac muscle, blood vessel and viscera tissue stiffness changing have important function.Myocardial ischemia, old myocardial infarction, hypertension, arteriosclerosis, tissue canceration, tissue calcification, fibrosis etc. can make biological tissue or internal organs hardness increase, and pathological tissues hardness such as myocardium dysplasia, cyst reduce.But the increase of organizing hardness is the function of appreciable impact internal organs also.Can cause diastolic heart failure as myocardium stiffness index increase; The cicatrix that old myocardial infarction forms causes the remarkable increase of regional myocardial stiffness index and influences the contraction and the diastolic function of heart; The hardness of tremulous pulse increases infringement elasticity of blood vessels and function; " cancer " word of Chinese has stone-like to organize the meaning of cirrhosis, and the unusual increase of the hardness of local organization may be that pathological changes such as cancer has taken place.Therefore detection by quantitative tissue, the especially hardness of deep organs and tissues have important value in medical research and clinical practice.
Organize cirrhosis to occur in more in heart, blood vessel and other deep body cavity, and lack direct detection method.Obtain directly to organize hardness very important to clinical diagnosis, the diastolic heart failure that causes as myocardium stiffness index increase has 4,000,000 people at least in China, uses " exclusive method " to diagnose clinically.This passive elasticity physical features of myocardium hardness (hardness or stiffness reflecting myocardium is being subjected to stress generation adaptability to changes) is directly related with patient's clinical manifestation, but at present owing to can not directly measuring " goldstandard " that myocardium hardness lacks reference.This field scholar feels disappointed to present situation, calls new signal detecting method and standard in a hurry." sclerosis of blood vessels " this inherent pathological manifestations is not directly measurement but relies on other method to infer at present.Can be used as the important supplement that gastroscope is diagnosed in SM gastric cancer as detecting its hardness.But shortage can directly be measured method and the instrument of organizing stiffness index at the deep body cavity at present.
The at present existing coining principle of utilizing by the human body tissue is applied certain pressure, and detects the deformation quantity of tissue with means such as ultrasonic, thereby the relation detection by quantitative of analyzing stress-strain compares the method for biological tissue's hardness.Prior art is used the stiffness index of coining method appraiser soma, as measure superficial tumor and cicatrix etc., can only be at body surface, or show shallow fabric analysis by straight hard extension and measure, these instruments are held or are installed on the machinery external by hands usually, volume is greatly and inadequately dexterous, more can not be implemented in the cardiac chambers, detect in the blood vessel and in other internal organs and organize hardness to be used to assist the requirement of medical diagnosis.But not coining technology (as doppler ultrasound etc.) is indirect to the detection of biological tissue stiffness indexs such as cardiovascular internal organs, and affected factor is more and accuracy is not high.Other class methods are to use core tube technology, the relationship change of the pressure-volume of analysis of cardiac detects the compliance of ventricle, thereby assess the method for myocardium stiffness index indirectly, this method adapts to the requirement of interventional minimally-invasive, that in fact obtain is ventricular chamber stiffness index constant (constant of chamber stiffness), be not the passive physical attribute of direct reflecting myocardium, be subjected to influence such as ventricle size and not accurate enough; Especially this method can not detect the variation of local organization (as the cicatrix that forms after the myocardium infarction, tumor by local tissue etc.) stiffness index.By the retrieval of follow-up study and dynamic document, obtain method and the instrument that structural stress-strain stress relation obtains cardiovascular organization and viscera tissue stiffness index in cardiovascular and other splanchnic cavity thereby still find no to enter by conduit.Enter in the cardiovascular system generally speaking, especially to obtain information in the chambers of the heart very difficult, along with the development and the standardization of cardiovascular interventional technique, the development and design of this instrument becomes possibility; On the other hand along with going deep into to disease Pathophysiology understanding, under some pathologic conditions, press for the stiffness index that obtains the human body biological tissue and be used for assisting diagnosis, as accurately obtaining myocardium stiffness index the diagnosis cardiac diastolic function there is decisive significance unusually, " the golden index " of quantification is provided for the hardened diagnosis of trunk.
The content of invention
One of purpose of the present invention provides a kind of insertion type ultrasonic tissue hardness by the core tube technology platform and obtains method.
Two of purpose of the present invention provides a kind of insertion type ultrasonic hardness detector.
According to described method, get involved internal organs " touch " deep tissue by conduit, the Young's modulus of the basic parameter-tissue of detection by quantitative characterizing tissues consistency and elasticity and other index are used for research and assist medical diagnosis, thereby invention gets involved cardiovascular and deep internal organs intracavity by microcatheter technology, utilize the water pocket of catheter tip that tissue is exerted pressure, utilize the deformation quantity of ultrasound detection tissue, organize counter stress to produce method-intervention ultrasonic tissue hardness detection method that adaptability to changes obtains to organize the hardness data by analysis.This programme is used sophisticated cardiovascular intervention diagnosis conduit as technical standard simultaneously, to be used to detect the ultrasonic probe microminiaturization of organizing deformation, monitoring tube is to organizing applied pressure in real time, use sophisticated controlled deflection microcatheter technology, design can be in body cavity flexible motion, tissues such as cardiac muscle, blood vessel, gastrointestinal tract are carried out conduit and the main frame that hardness detects.This programme is applied to the cooking technique combination, realize the conduitization of ultrasonic coining diagnostic system, thereby invention is obtained instrument-ultrasound catheter hardness detecting instrument through catheter-based ultrasound hardness detection method and corresponding intervention ultrasonic hardness, for the detection of cardiovascular and deep viscera tissue hardness provides approach and method.
For achieving the above object one, the technical solution used in the present invention is such, and promptly a kind of catheter-based ultrasound hardness information is obtained method, and method may further comprise the steps:
1, sets up or sets up ultrasonic transducer and the pressure sensor structure that carries by interposing catheter;
2, by can pressure being applied to tested tissue by water pocket at the external interposing catheter of controlling, this power that applies is by pressure transducer real-time continuous record; Simultaneously, the detected variation of organizing echo signal in the pressurized process of the reception of ultrasonic transducer real-time continuous, and the image by M type ultrasonic cardiography chart-pattern display organization varied in thickness;
3, stack between the image of time dependent curve of build-up pressure signal and M type ultrasonic cardiography chart-pattern display organization varied in thickness or contrast figure; Choosing on described stack or contrast figure needs detection period image to freeze frame, and pressurization or decompression time section on the pressure force curve are measured its pressure and changed numerical value and change value of thickness then;
4, after organizing deformation quantity and detected pressure value to obtain, according to the relation that is applied to structural pressure and deformation, with the ratio characterizing tissues hardness of above-mentioned force value and change value of thickness; Simultaneously can utilize formula E=P (1-ν
2)/2aw κ (ν, a/h) the Young's modulus E of the tested tissue of acquisition, p is the power that applies in the formula, and w is that deformation quantity is a change value of thickness, and a is a coining water pocket radius, ν is a Poisson's ratio, the general biological tissue value 0.45 of this Poisson ratio, h is tested tissue thickness, κ is a scale factor, when a/h less than 1/2 the time, but the κ value is 1.
For realizing that the technical scheme that second purpose of the present invention adopts is such, it is a kind of intervention ultrasonic hardness detector, comprise ultrasonic hardness detected catheter and main frame, it is characterized in that: the head end of conduit is fixed with the liquid capsule, be fixed with ultrasonic transducer after the liquid capsule, the head end or the end of conduit are equipped with pressure transducer, the conduit head end be fixed with support collar and be attached thereto control tension wire, the terminal attended operation handle of conduit, the terminal jacket bottom of described operating grip connects controls tension wire; The supply lines of described ultrasonic transducer and holding wire are passed with main frame by the end of conduit and are connected.
When described conduit was the single tube structure, fixed ultrasonic transducer was a cylinder after the liquid capsule, setting pressure pick off between liquid capsule and ultrasonic transducer; When conduit was the coaxial double-pipe structure, ultrasonic transducer was the ring-type cylinder, was installed between the central canal and outer tube of conduit head end, and the liquid capsule is communicated with the central canal head end, and pressure transducer is installed in the liquid capsule threeway that is communicated with the central canal end; The power line of conduit is connected with main frame with the signal wire via cable line.
Described main frame comprises ultrasonic amplifier, pressure amplifier, ecg amplifier, A/D conversion, the control CPU of central authorities, control panel, monitor; Wherein said ultrasonic transducer emission and the ultrasonic signal that receives are controlled the cpu data input with central authorities and are connected, and the signal that transducer receives is sent into the control CPU of central authorities after amplification and A/D conversion, show tested tissue thickness in M type mode; Described pressure transducer is accepted to be organized applied pressure to pressing in real time, and its pressure signal is sent into the control CPU of central authorities after amplification and A/D conversion, show the pressure variation with curve mode.Ecg amplifier is gathered electrocardiosignal in real time and send into central authorities' control after the A/D conversion, shows the electrocardiogram curve.The control CPU of central authorities is the main frame core, control ultrasound transmit signal, analytical calculation and the ultrasonic and pressure signal of demonstration echo.Control panel improves on common diasonograph, is connected with central authorities control CPU, is used for control instrument state, input data and data, measures etc.Ultrasonic, pressure and electrocardiosignal are integrated the back and are shown ultrasonic signal at display with M pattern formula, and show physiological signals such as pressure electrocardiogram with the screen synchronous dynamic, press data such as this programme display organization hardness curve.
Compare with prior art, the good effect that the present invention produces is:
(1), device conduitization: overcome existing coining hardness detection method and device and be difficult to difficulty that deep even cardiovascular organization hardness are detected.By the core tube technology platform, the technical standard by cardiac catheter is easy to enter heart and trunk safely by vagina vasorum; And enter internal organs by this standard and do not have obvious technical difficulty.Extend sense of touch by conduit, make the hardness of perception cardiac muscle, trunk and internal organs become possibility.
(2), can be handling: effectively realize different target sites are organized obtaining of hardness.Utilize the technology such as controlled curved of conduit to be implemented in external use X line, endoscope, technology guiding such as ultrasonic arrives the test section position, utilize the camber of different sizes, shape, the detection of hardness is organized at local " point " position of realization, provides basic skills for local organization hardness detects.
(3), the water pocket at conduit top: design helps protective tissue, detects accurately and conducting pressure.Help evenly conducting exactly, help ultrasonic to the accurate detection of organizing the coining degree of depth and avoid damage detected tissue to organizing applied pressure.
(4), directly obtain the hardness and the Young's modulus of tested tissue, the software that utilizes this programme to provide, the consistency and elasticity information of the tested tissue of convenient acquisition.
The present invention can directly obtain the stress that tested tissue bears and the strain of this tissue generation simultaneously, and measuring, be provided with and calculating automatically by simple on the image intuitively, can obtain to organize the fundamental physical quantities such as consistency and elasticity modulus of passive deformability, organize hardness for scientific research and Clinical detection and provide directly, means and method easily.
Description of drawings:
Fig. 1 is an apparatus structure sketch map of the present invention;
Fig. 2 is the section enlarged diagram of conduit head end;
Fig. 3,4 is respectively A-A, the B-B generalized section of Fig. 2;
Fig. 5 is the structure principle chart of device of the present invention.
Referring to accompanying drawing: 1-water pocket threeway among the figure, 2-power line plug receptacle, 3-conduit extension line, 4-conduit operator are bright, 5-guiding-tube bend pull bar, 6-catheter body, 7-conductor housing, 8-tension wire, 9-ultrasonic transducer power line, 10-support metal ring, 11-ultrasonic transducer backing, 12-piezoelectric ceramics, 13-matching layer, 14-water pocket, 15-catheter wall, 16-aqueduct, 17-tension wire attachment point, 18-are filled bonded adhesives.
The specific embodiment
The overall dimensions of detected catheter is similar to the radio-frequency ablation electrode conduit.Conduit external diameter 6F can enter left ventricle, aortic arch, thoracoabdominal aorta etc. through approach such as femoral artery, radial arterys by vagina vasorum, through femoral vein can enter caval vein, system is felt concerned about until pulmonary artery in the right side.Directly or by endoscope enter stomach, esophagus, colon or uterus; Enter (as by peritoneoscope) such as splanchnocoels by the celioscope technology and can enter the abdominal cavity.
The controlled deflection principle of detected catheter is similar to the radio-frequency ablation electrode conduit.By to the tested stress application of organizing, or obtain hardness parameter by easypro the contracting of internal organs self.The curved size of conduit is done different selections according to character such as tested internal organs different chamber sizes.
The liquid capsule that is installed in catheter tip requires when conduit is exerted pressure to tissue water pocket indeformable substantially, and ultrasonic detection to water pocket contact tissue thickness has very high precision.
The cylindric low conforming materials (as polyurethane film) of the top of described conduit molding in advance but fluid filled sac, the high about 2mm of liquid capsule, the about 2mm of diameter, cyst wall has enough tension force (more than 1 atmospheric pressure,＞760mmHg), the liquid capsule does not have obvious deformation when light pressure is organized, and the top of liquid capsule is similar to a plane.Ultrasonic transducer front end behind the liquid capsule has acoustic lens matching layer 13, can make it that higher accuracy of detection be arranged sound beam focusing.
Conduit is sent in the body in common interposing catheter mode, conductor housing along vertical tested organizer to contacting with different dynamics with tissue surface with water pocket, pressure to tissue obtains the real-time pressure curve by water pocket liquid conductive to pressure transducer, tissue is subjected to water pocket and presses the back in the certain deformation of conduit long axis direction generation, and this deformation shows and record with screen synchronously by high-resolution ultrasound detection and with M type ultrasound mode and pressure and electrocardiogram curve.Use the computer software that this programme provides, change organizing applied pressure and tissue thickness by some time period of synchro measure, can obtain hardness constant K value, and can calculate the Young's modulus of biological tissue according to formula.
Because tissues such as cardiac muscle, trunk are the pseudo-elastic approximation tissues, available elastomeric material method is similar to research.It is exponential curve in the pass of the deformation quantity of thickness direction generation that biological tissue is subjected to coining power, its stiffness index is the tangent slope of stress-strain curve, but its stress-strain relation is good linear relationship (＜137 gram/square centimeters when less stress, 2 mm dias probe), promptly so-called increment law.So, can obtain the hardness number of tissue by linear analysis by corresponding its strained measured value of 2 stress, and can utilize formula E=P (1-ν as long as use suitable pressure
2(ν a/h) obtains the Young's modulus of tested tissue to)/2aw κ, thereby is used for comparative study and assists medical diagnosis.
Method may further comprise the steps:
A, set up or set up ultrasonic transducer and pressure sensor structure by interposing catheter carrying;
B, by interposing catheter pressure is applied to tested tissue, this power that applies is by pressure transducer real-time continuous record; Simultaneously, the detected variation of organizing echo signal in the pressurized process of the acceptance of ultrasonic transducer real-time continuous, and the image by M type ultrasonic cardiography chart-pattern display organization varied in thickness.
Stack between the image of c, build-up pressure signal curve and M type ultrasonic cardiography chart-pattern display organization varied in thickness or contrast figure; Select detected pressures and deformation thickness to show that synchronously good image freezes frame on described stacking chart, pressurization or decompression time section on the pressure force curve are measured its pressure and are changed numerical value and change value of thickness then;
D, elastomer detection method: will organize and do pseudo-elastic approximation research, hardness and Young's modulus are organized in measurement: its hardness and Young's modulus are the common index of characterizing tissues hardness, by setting up the tested range of normal value of organizing hardness or Young's modulus, can judge whether organize hardness normal, thereby be used to assist medical research or clinical diagnosis.According to the relation of applied pressure and deformation, with the ratio characterizing tissues hardness of pressure and deformation; Utilize formula E=P (1-ν
2(p is the power that applies to)/2aw κ in the formula for ν, a/h) the Young's modulus E of the tested tissue of acquisition, w is a deformation quantity, and a is a coining water pocket radius, and ν is Poisson's ratio (a general biological tissue value 0.45), h is tested tissue thickness, κ be scale factor (when a/h less than 1/2 the time, but the κ value is 1).As p=0.1N, W=1.2 * 10
-3M, a=1 * 10
-3M, κ=1, the Young's modulus that calculates this specimen according to following formula is E=3.33 * 10
4Pa.
E, synchronous monitoring electrocardiosignal are analyzed when assisting detection mutually.As can help us to differentiate the systole and the relaxing period of heart when carrying out cardiac measurement, when being measured, other guard.
(4), get involved ultrasonic tissue hardness information and obtain flow process
The ultrasound detection conduit enters in the body with X line, endoscope, celioscope, medical image technology guiding such as ultrasonic and arrives the test section position.Instrument host CPU sends control signal to supersonic signal generator, and the latter is activated at the ultrasonic transducer of catheter tip, transmitted pulse ultrasonic signal by lead.The water pocket of the ultrasound wave that transducer produces by the place ahead enters and is detected tissue, and the echo-signal of tissue is received by same transducer, shows along the time expansion mode with the one dimension gray scale after host process, promptly obtains M type ultrasound mode and shows.Tested thickness of tissue, position are over time by clear demonstration.Simultaneously to organizing applied pressure to be detected and show with screen with the mode of pressure curve and ultrasonic while of M type by pressure transducer, phase when demarcating cardiac cycle, electrocardiogram also shows with screen in real time.After obtaining satisfied image, freeze frame and to measure the deformation of organizing applied pressure and the tissue generation of same time period section sometime, measured value calculates after entering computer automatically, can obtain the consistency and elasticity parameter of detected portion bit organization.
(1), the function of the structure of instrument and critical piece
Described instrument comprises ultrasonic hardness detected catheter and main frame, the head end of ultrasonic hardness detected catheter is fixed with liquid capsule 14, be fixed with ultrasonic transducer after the liquid capsule, the conduit head end be fixed with support ring 10 and be attached thereto control tension wire 8, ultrasonic transducer is by matching layer 13, piezoelectric ceramics 12 and the ultrasonic transducer backing is stacked is bonded as one; The supply lines of ultrasonic transduction element and holding wire are passed by the end of conduit; The terminal attended operation handle 4 of conduit, the terminal jacket bottom of described operating grip connects controls tension wire 8, the pull bar 5 of sliding catheter bending backward, tension wire tensioning, guiding-tube bend.
That accompanying drawing provides is the embodiment of an indefiniteness, when the detected catheter of ultrasonic hardness described in the embodiment is the double pipe structure of concentricity axle, ultrasonic transducer is the ring-type cylinder, be installed between the central canal and outer tube of conduit head end, the liquid capsule is communicated with the central canal head end, pressure transducer be installed in terminal with central canal or the liquid capsule threeway that is communicated with it in; The power line of conduit is connected with main frame with the signal wire via cable line.
Referring to accompanying drawing 4, described main frame comprises ultrasonic amplifier, pressure amplifier, ecg amplifier, A/D conversion, the control CPU of central authorities, control panel, monitor composition; Wherein said ultrasonic transducer emission and the ultrasonic signal that receives are connected with the control CPU of central authorities, and the signal that transducer receives is sent into the control CPU of central authorities after amplification and A/D conversion, show tested tissue thickness in M type mode; Described pressure transducer is accepted to be organized applied pressure to pressing in real time, and its pressure signal is sent into the control CPU of central authorities after amplification and A/D conversion, show the pressure variation with curve mode.Ecg amplifier is gathered electrocardiosignal in real time and send into central authorities' control after the A/D conversion, shows the electrocardiogram curve.The control CPU of central authorities is the main frame core, control ultrasound transmit signal, analytical calculation and the ultrasonic and pressure signal of demonstration echo.Control panel improves on common diasonograph, is connected with central authorities control CPU, is used for control instrument state, input data and data, measures etc.Ultrasonic, pressure and electrocardiosignal are integrated the back and are shown ultrasonic signal at display with M pattern formula, and show physiological signals such as pressure electrocardiogram with the screen synchronous dynamic, press this programme display organization hardness curve etc.
It is AD623AN that described in an embodiment ultrasonic amplifier, pressure amplifier, ecg amplifier can adopt model respectively, ISO.ECG-1mV: isolate ecg amplifier entirely.Wherein ultrasonic transducer and amplifier are bought by Shantou ultrasonic investigation.Pressure transducer and amplifier thereof are provided by Bangbu meridian instrument instruments and meters element factory.Ecg amplifier is gathered electrocardiosignal in real time and send into central authorities' control after the A/D conversion, shows the electrocardiogram curve, and ecg amplifier is provided by Haidian, Beijing auspicious cloud computer technology company.
The vertical liquid capsule of conductor housing in the said apparatus, harder column water pocket of feasible one-tenth (2 millimeters of diameters, high 2 millimeters) under setting pressure (1 atmospheric pressure); Ultrasonic transducer can and receive ultrasonic along the emission of conduit long axis direction; But the pressure transducer real-time continuous is the variation of monitoring pressure critically; The support metal ring is fixed on the inner catheter, controls the outer side that steel wire is connected support metal ring 10; With outer catheter bulk phase be connected the blended rubber sealing thereafter; Interior Guan Weiyi end water pocket is communicated with the other end and water pocket threeway 1 water pipe connecting 16.
When instrument is worked, after the ultrasonic hardness detected catheter enters heart, trunk or internal organs chamber or body cavity by cardiovascular intervention requirement, interior interface tube is connected with the static pressure pump by the water pocket threeway, compression pump feeds normal saline or contrast agent in interior pipe, give certain static pressure (an about atmospheric pressure), form a little column liquid capsule on the conductor housing top by interior pipe.Because 1 atmospheric static pressure arranged, to organizing the shape that can keep its water pocket when pressing gently.
Conductor housing is controlled to be adjusted under medical images monitoring guiding needs sites measured, the operation conduit applies certain pressure to tested tissue, ultrasonic transducer and pressure transducer synchronous working, detection simultaneously is organized in when bearing different pressures, organizes the variation of wall thickness.Ultrasonic transducer is along conduit long axis direction forward emitted and receive monophone bundle high frequency ultrasound (about 10MHz); The sampling of pressure transducer high frequency forms continuously dynamic pressure curve.The pressure that tissue bears changes.Be transferred to the usefulness of main frame during information of same that ultrasound catheter changes pressure and tissue thickness for analysis and research
Main frame is handled the back with ultrasonic signal and is presented on the display with M type ultrasonic diagnosis pattern, and pressure and electrocardiogram curve also can be distinguished overlapping being presented in the same picture frame in ground simultaneously.The relation that the process of measurement of main frame (identical with high-resolution M type ultrasoundcardiogram process of measurement, vertically certainty of measurement is 0.1 millimeter) internal organs wall thickness and motion change and pressure change calculates the detected numerical value of organizing stiffness index.
The present invention is owing to the beneficial effect that described method and device produce is as follows:
A, the present invention are used for deep internal organ group by microcatheter technology with ultrasonic coining hardness detection method first The detection of knitting, the most direct method of usefulness obtains the relation of some human body deep vital tissue stress-strains, from And can directly obtain first the quantitative hardness information of internal organs such as cardiovascular, the hand that resembles us can be direct " touch " makes its quantification and more accurate to tissues such as cardiac muscles.
B, accurately seek and visit the hardness of human body deep tissue, for understanding human pathology's state, diagnosing the illness and carry For important or even decisive foundation. The master who causes the cardiac diastolic function obstacle such as myocardium stiffness index increase Want factor, can arrive myocardium stiffness index people and living animal direct-detection without any method so far. The present invention can the direct quantitative collection obtains represent cardiac muscle or the signal parameter of the stiff degree organized, is the heart The dirty diastolic function not diagnosis of congruent disease provides objective direct foundation.
Claims (5)
1, a kind of insertion type ultrasonic tissue hardness is obtained method, and method may further comprise the steps:
(1) sets up or sets up ultrasonic transducer and the pressure sensor structure that carries by interposing catheter;
(2) by can pressure being applied to tested tissue by water pocket at the external interposing catheter of controlling, this power that applies is by pressure transducer real-time continuous record; Simultaneously, the detected variation of organizing echo signal in the pressurized process of the reception of ultrasonic transducer real-time continuous, and the image by M type ultrasonic cardiography chart-pattern display organization varied in thickness;
(3) stack between the image of time dependent curve of build-up pressure signal and M type ultrasonic cardiography chart-pattern display organization varied in thickness or contrast figure; Choosing on described stack or contrast figure needs detection period image to freeze frame, and pressurization or decompression time section on the pressure force curve are measured its pressure and changed numerical value and change value of thickness then;
(4) after organizing deformation quantity and detected pressure value to obtain, according to the relation that is applied to structural pressure and deformation, with the ratio characterizing tissues hardness of above-mentioned force value and change value of thickness; Simultaneously can utilize formula E=P (1-ν
2)/2aw κ (ν, a/h) the Young's modulus E of the tested tissue of acquisition, p is the power that applies in the formula, and w is that deformation quantity is a change value of thickness, and a is a coining water pocket radius, ν is a Poisson's ratio, the general biological tissue value 0.45 of this Poisson ratio, h is tested tissue thickness, κ is a scale factor, when a/h less than 1/2 the time, but the κ value is 1.
2, a kind of intervention ultrasonic hardness detector comprises ultrasonic hardness detected catheter and main frame, it is characterized in that: the head end of conduit is fixed with liquid capsule (14), is fixed with ultrasonic transducer after the liquid capsule, and the head end or the end of conduit are equipped with pressure transducer; The conduit head end be fixed with support collar and be attached thereto control tension wire, the terminal attended operation handle of conduit, the terminal jacket bottom of described operating grip connects controls tension wire; Power line in the conduit is connected with main frame with the signal wire via cable line.
3, intervention ultrasonic hardness detector according to claim 2, it is characterized in that: described conduit is the single tube structure, ultrasonic transducer is a cylinder, setting pressure pick off between liquid capsule and ultrasonic transducer.
4, intervention ultrasonic hardness detector according to claim 2, it is characterized in that: conduit is concentricity axle double pipe structure, ultrasonic transducer is the ring-type cylinder, be installed between the central canal and outer tube of conduit head end, the liquid capsule is communicated with the central canal head end, and pressure transducer is installed in the liquid capsule threeway that is communicated with the central canal end.
5, get involved the ultrasonic hardness detector according to claim 2, it is characterized in that: described ultrasonic transducer is bonded as one by matching layer (13), piezoelectric ceramics (12) and ultrasonic transducer backing are folded layer by layer; The supply lines of ultrasonic transduction element and holding wire are passed by the end of conduit; The terminal attended operation handle (4) of conduit, the terminal jacket bottom of described operating grip connects controls tension wire (8).
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Cited By (7)
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| CN100384380C (en) * | 2006-02-27 | 2008-04-30 | 黄晶 | Intracavity ultrasonic hardness colour imaging method and its coelom ultrasonic hardness imaging instrument |
| WO2009132515A1 (en) * | 2008-04-29 | 2009-11-05 | 香港理工大学 | Wireless ultrasonic scanning system |
| CN101842701A (en) * | 2007-10-01 | 2010-09-22 | 生物谐振器公司 | Method and arrangement for unaffected material analyse |
| CN106794003A (en) * | 2014-07-17 | 2017-05-31 | 国家健康与医学研究院 | The method for obtaining the functional parameter of muscle |
| CN107582101A (en) * | 2016-07-06 | 2018-01-16 | 韦伯斯特生物官能(以色列)有限公司 | Determine tissue thickness |
| CN108430653A (en) * | 2015-12-24 | 2018-08-21 | 奥林巴斯株式会社 | Ultrasonic oscillator |
| CN113974563A (en) * | 2016-12-19 | 2022-01-28 | 麦克赛尔株式会社 | Hardness meter and hardness measuring method |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384380C (en) * | 2006-02-27 | 2008-04-30 | 黄晶 | Intracavity ultrasonic hardness colour imaging method and its coelom ultrasonic hardness imaging instrument |
| CN101842701A (en) * | 2007-10-01 | 2010-09-22 | 生物谐振器公司 | Method and arrangement for unaffected material analyse |
| WO2009132515A1 (en) * | 2008-04-29 | 2009-11-05 | 香港理工大学 | Wireless ultrasonic scanning system |
| CN106794003A (en) * | 2014-07-17 | 2017-05-31 | 国家健康与医学研究院 | The method for obtaining the functional parameter of muscle |
| US10881380B2 (en) | 2014-07-17 | 2021-01-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for obtaining a functional parameter of a muscle |
| CN108430653A (en) * | 2015-12-24 | 2018-08-21 | 奥林巴斯株式会社 | Ultrasonic oscillator |
| CN107582101A (en) * | 2016-07-06 | 2018-01-16 | 韦伯斯特生物官能(以色列)有限公司 | Determine tissue thickness |
| CN107582101B (en) * | 2016-07-06 | 2022-05-27 | 韦伯斯特生物官能(以色列)有限公司 | Determining tissue thickness |
| CN113974563A (en) * | 2016-12-19 | 2022-01-28 | 麦克赛尔株式会社 | Hardness meter and hardness measuring method |
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