CN1660843A - Matrine and salt of organic acid of oxidized matrine and its prepn. process - Google Patents
Matrine and salt of organic acid of oxidized matrine and its prepn. process Download PDFInfo
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- CN1660843A CN1660843A CN 200410006314 CN200410006314A CN1660843A CN 1660843 A CN1660843 A CN 1660843A CN 200410006314 CN200410006314 CN 200410006314 CN 200410006314 A CN200410006314 A CN 200410006314A CN 1660843 A CN1660843 A CN 1660843A
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- China
- Prior art keywords
- matrine
- acid
- organic
- oxymatyine
- organic acid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An organic acid's salt of matrine or matrine oxide is prepared from the matrinx or matrine oxide through reacting on organic acid in water and/or organic solvent. It can be used to prepare medicine with high stability and easy absorption.
Description
The present invention relates to medicinal compounds and technical field thereof, exactly it is that a kind of matrine and Oxymatyine are made the organic acid salt compound, and this compounds is fit to make various preparations.
Matrine (Matrine) separates the alkaloid that obtains with Oxymatyine (Oxymatrine) from pulse family Sophoras such as kuh-sengs, is extensive use of as medicines such as anti-arrhythmia, anti inflammatory immunity, antiviral, antitumor and living white corpuscle and thrombocytes clinically.All make various preparations at present and use with its alkaloid, but defective such as pain and absorptivity difference when having its stability, intramuscular injection.We have solved the problems referred to above after being made into organic salt, be convenient to medicine long storage, sense and be convenient to muscle and absorb eases the pain.
The objective of the invention is to: matrine and Oxymatyine are made organic acid salt, increase its stability, pain when alleviating intramuscular injection and increase muscle absorption rate heat and air.
The inventor has found a kind of matrine and Oxymatyine organic acid salt preparation method through conscientiously research.
The present invention prepares matrine and Oxymatyine organic acid salt method is: with matrine or Oxymatyine and etc. mole or greater than equimolar organic acid reaction, solvent for use is the mixed solvent of water, organic solvent or water and organic solvent, by filtering, or, obtain white or off-white color solid after the vacuum-drying with the solvent for use evaporate to dryness.This compounds can be made into tablet, granule, capsule, injection and external ointment etc.
Acid used in the present invention is to be included in all organic monoprotic acid, diprotic acid, amino acid, sulfonic acid, phosphoric acid etc. under the organic acid notion.For example formic acid, methylsulfonic acid, acetate, oxalic acid, lactic acid etc.
Advantage of the present invention is after matrine and Oxymatyine exist with the organic acid salt form, and is good to heat and air stability, particularly makes ease the pain sense and be convenient to muscle absorption of injection.
Following embodiment further specifies the present invention.The preparation method who it should be understood that the embodiment of the invention only is used to illustrate the present invention, rather than limitation of the present invention, under design prerequisite of the present invention described content of the present invention is carried out simple modifications and all belongs to the scope of protection of present invention.
Embodiment 1: the preparation of acetic acid matrine:
The 1mole matrine is dissolved in the 200ml ethanol, and agitation condition added 1mole acetic acid room temperature reaction down 2 hours, removal of solvent under reduced pressure, and vacuum-drying obtains white or off-white color solid, yield 98.5%.
Embodiment 2: the preparation of lactic acid matrine:
The 1mole matrine is dissolved in the 200ml ethanol, and agitation condition added 1mole lactic acid back flow reaction down 2 hours, removal of solvent under reduced pressure, and vacuum-drying obtains white or off-white color solid, yield 98%.
Embodiment 3: the preparation of lactic acid Oxymatyine:
The 1mole Oxymatyine is dissolved in the 200ml ethanol, and agitation condition added 1mole lactic acid back flow reaction down 2 hours, removal of solvent under reduced pressure, and vacuum-drying obtains white or off-white color solid, yield 97%.
Claims (5)
1. matrine and Oxymatyine organic acid salt and preparation method thereof is characterized in that: the organic salt that matrine or Oxymatyine and organic acid form, organic acid comprises all organic monoprotic acid, diprotic acid, amino acid, sulfonic acid, phosphoric acid etc.For example formic acid, methylsulfonic acid, acetate, oxalic acid, lactic acid etc.
2. matrine according to claim 1 and Oxymatyine organic acid salt with folk prescription or compound as the pharmaceutical preparation component.
3. the various formulations such as tablet, capsule, granule, injection and external ointment that matrine according to claim 2 and Oxymatyine organic acid salt are made as the pharmaceutical preparation component with folk prescription or compound.
4. matrine according to claim 1 and Oxymatyine organic acid salt and preparation method thereof, matrine or Oxymatyine and etc. the mole or greater than equimolar organic acid reaction salify.
5. matrine according to claim 4 and Oxymatyine organic acid salt and preparation method thereof solvent for use is the mixed solvent of water, organic solvent or water and organic solvent, and organic solvent comprises methyl alcohol, ethanol, acetone, tetrahydrofuran (THF) etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410006314 CN1660843A (en) | 2004-02-25 | 2004-02-25 | Matrine and salt of organic acid of oxidized matrine and its prepn. process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410006314 CN1660843A (en) | 2004-02-25 | 2004-02-25 | Matrine and salt of organic acid of oxidized matrine and its prepn. process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1660843A true CN1660843A (en) | 2005-08-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410006314 Pending CN1660843A (en) | 2004-02-25 | 2004-02-25 | Matrine and salt of organic acid of oxidized matrine and its prepn. process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1660843A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101585838B (en) * | 2009-06-15 | 2011-07-20 | 西南大学 | Matrine sodium sulfonate and preparation method |
| CN109908018A (en) * | 2019-03-27 | 2019-06-21 | 广东萱嘉医品健康科技有限公司 | A kind of γ-aminobutyric acid ionic liquid and the preparation method and application thereof |
| CN113694175A (en) * | 2021-08-11 | 2021-11-26 | 深圳市萱嘉生物科技有限公司 | Sophora flavescens base ionic liquid conotoxin polypeptide solution, preparation method and application thereof |
-
2004
- 2004-02-25 CN CN 200410006314 patent/CN1660843A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101585838B (en) * | 2009-06-15 | 2011-07-20 | 西南大学 | Matrine sodium sulfonate and preparation method |
| CN109908018A (en) * | 2019-03-27 | 2019-06-21 | 广东萱嘉医品健康科技有限公司 | A kind of γ-aminobutyric acid ionic liquid and the preparation method and application thereof |
| CN109908018B (en) * | 2019-03-27 | 2020-05-19 | 广东萱嘉医品健康科技有限公司 | Gamma-aminobutyric acid ionic liquid and preparation method and application thereof |
| CN113694175A (en) * | 2021-08-11 | 2021-11-26 | 深圳市萱嘉生物科技有限公司 | Sophora flavescens base ionic liquid conotoxin polypeptide solution, preparation method and application thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |