CN1660257A - Soft capsule of extractive from leaves of persimmon and self-emulsifying system for releasing drug - Google Patents
Soft capsule of extractive from leaves of persimmon and self-emulsifying system for releasing drug Download PDFInfo
- Publication number
- CN1660257A CN1660257A CN 200410077784 CN200410077784A CN1660257A CN 1660257 A CN1660257 A CN 1660257A CN 200410077784 CN200410077784 CN 200410077784 CN 200410077784 A CN200410077784 A CN 200410077784A CN 1660257 A CN1660257 A CN 1660257A
- Authority
- CN
- China
- Prior art keywords
- folium kaki
- kaki extract
- soft capsule
- oil
- self
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000010998 test method Methods 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- 239000010913 used oil Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A softgel of persimmon leaf extract and its self-emulsifying medicine release system are disclosed, which feature that said extract of persimmon leaf in the state of suspension or solution is contained in the softgel and in molecular state exists in the self-emulsifying medicine release system for promoting the absorption to it.
Description
[technical field]
The present invention relates to medical technical field, is the soft capsule of Folium Kaki extract; With a kind of new oral medicine-releasing system of Folium Kaki extract, i.e. Folium Kaki extract self-emulsifying drug delivery system.
[background technology]
Folium Kaki extract mainly contains flavonoid, tannin, phenols, coumarin, organic acid, carotene, number of chemical compositions such as vitamin C also have pharmacological action widely, wherein be main component with the total flavones, the Folium Kaki flavone chemical compound of having found at present has astragalin, isoquercitin, kaempferol 3-o-β-D-glycoside, kaempferol, Quercetin, kaempferol 3-o-α-L-rhamnose Portugal glycoside, kaempferol 3-o-β-D-xyloside, kaempferol 3-o-α-L-arabinose Portugal glycoside, Quercetin 3-o-[2 "-o-(3.4.5.-trihydroxy benzene formyl)]-glycoside; myricitrin; astragalin etc.Studies show that Folium Kaki extract and Folium Kaki flavone glycoside have blood pressure lowering, antibacterial, blood fat reducing, cholesterol reducing, hemostasis, physiological functions such as function of nervous system's degeneration are grown, prevented to blood circulation promoting and blood stasis dispelling, inhibition carcinoma, can be used for preventing and treating cerebral arteriosclerosis, angina pectoris, ischemic cerebrovascular, alzheimer disease etc.
At present, has only a kind of dosage form of Folium Kaki extract tablet on the market.But, generally exist and absorb relatively poor problem in vivo for flavones ingredient.And, for the tablet of Chinese medicine extract, also exist the slow problem of disintegration rate, because therefore the Folium Kaki extract bitter in the mouth also must carry out coating to tablet, not only make preparation process more loaded down with trivial details, also further hindered the disintegration time of tablet.Therefore, loaded down with trivial details for overcoming tablet manufacturing technology, disintegration time long (in the body release slow, absorb slow, onset is slow), problem such as bioavailability is low, carried out the present invention hereby: (1) has invented soft capsule of extractive from leaves of persimmon; (2) invented the Folium Kaki extract self-emulsifying drug delivery system.
[summary of the invention]
Loaded down with trivial details for overcoming Folium Kaki extract tablet manufacturing technology, problem such as disintegration time long (release is slow, onset is slow), bioavailability are low, the present invention has been prepared into soft capsule of extractive from leaves of persimmon and Folium Kaki extract self-emulsifying drug delivery system respectively with Folium Kaki extract.
In the soft capsule of extractive from leaves of persimmon, Folium Kaki extract is suspended in or is dissolved in soft capsule content disperse medium or the solvent.Disperse medium or solvent are various natural or vegetable oil or its mixture transformed; Perhaps formed by main with PEG class (as PEG400).Contain Folium Kaki extract 2～200mg in every soft capsule.
The Folium Kaki extract self-emulsifying drug delivery system comprises Folium Kaki extract and adjuvant, and adjuvant contains emulsifying agent, co-emulsifier, oil phase or wherein two kinds, and the weight ratio of each component is: Folium Kaki extract 1～50%, adjuvant 50～99%.Following material as the weight ratio that adjuvant may occupy in medicine-releasing system is: emulsifying agent 1～95%, co-emulsifier 0～95%, oil phase 1～50%.Emulsifying agent can use a kind of in lecithin, polyoxyethylene (hydrogenation) Oleum Ricini, Labrafac CM 10, Labrafil M 1944 CSD, Labrafil M 2125 CS, Tagat TO, these materials of Tween 80, Labrasol, perhaps by two or more mixture formed in these materials; Co-emulsifier can use a kind of in ethanol, propylene glycol, glycerol, Polyethylene Glycol (molecular weight is at 200-600), propylene carbonate (propylene carbonate), ethylene glycol monomethyl ether (transcutol), glycerol furfural, these materials of dimethyl Soquad, perhaps by two or more mixture formed in these materials; Oil phase is a crude vegetal, or through vegetable oil or fatty acid ester after structure of modification and the hydrolysis, the medium chain fatty glyceride of chain length between C8～C10 particularly, for example Arlacel 80, Arlacel86, Capmul MCM, Captex 200 (oil), Captex 355 (oil), Miglyol812 (oil), Myvacet (oil), Myverol 18-92, olein, glyceryl linoleate, the Polyethylene Glycol glyceryl laurate ester, ethyl oleate, a kind of in these materials such as Ethyl linoleate is perhaps by two or more mixture formed in these materials.
This Folium Kaki extract self-emulsifying drug delivery system is a kind of dosage form that can be taken orally, and comprises various dosage forms such as capsule, soft capsule, solution.Content can carry out self emulsifying in water-bearing media.
[specific embodiment]
1, soft capsule of extractive from leaves of persimmon
The soft capsule of extractive from leaves of persimmon that the present invention relates to is to adopt disperse medium or solvent with the Folium Kaki extract high degree of dispersion or be dissolved in wherein, obtains the content of soft capsule of extractive from leaves of persimmon, it is suppressed in soft capsule getting final product.
Solvent that soft capsule content adopted or disperse medium both can be various natural or the vegetable oil of transformation such as the mixture of salad oil, soybean oil, Semen Maydis oil, olive oil, Semen arachidis hypogaeae wet goods or several oil; Can be again solvent or the disperse medium of being formed based on PEG class (as PEG400).
Soft capsule is in vivo after the disintegrate, but rapid release goes out content, and the content of liquid condition is scattered in the gastrointestinal tract with bigger area, has therefore significantly increased the absorption area of medicine, and infiltration rate and onset speed must be accelerated in its body.
Embodiment one
Folium Kaki extract 50g
Soybean oil 330g
Cera Flava 10g
Petiolus Trachycarpi oil 20g
Make 1000 soft capsules altogether
The Folium Kaki extract, soybean oil, Cera Flava, Petiolus Trachycarpi oil of getting recipe quantity are in 50 ℃ of stirred in water bath, mixing.Suspended matter is put in the colloid mill circular grinding 2 times, with gained suspension and gelatin (being offset plate or the adhesive tape made from behind gelatin and glycerol, the water dissolution) under 25 ± 2 ℃, relative humidity 40% condition, be pressed into 1000 of the soft capsules of regulation content of dispersion through automatic rotation rolling capsule machine, under 28 ± 2 ℃, relative humidity 40% condition with dry 20 hours of capsule, promptly.
Embodiment two
Folium Kaki extract 50g
Salad oil 330g
Phosphatidase 11 0g
Cera Flava 10g
Make 1000 soft capsules altogether
The Folium Kaki extract, soybean oil, Cera Flava, phospholipid of getting recipe quantity are in 50 ℃ of stirred in water bath, mixing.Suspended matter is put in the colloid mill circular grinding 2 times, with gained suspension and gelatin (being offset plate or the adhesive tape made from behind gelatin and glycerol, the water dissolution) under 25 ± 2 ℃, relative humidity 40% condition, be pressed into 1000 of the soft capsules of regulation content of dispersion through automatic rotation rolling capsule machine, under 28 ± 2 ℃, relative humidity 40% condition with dry 20 hours of capsule, promptly.
Embodiment three
Folium Kaki extract 200g
Oleum Arachidis hypogaeae semen 250g
Phosphatidase 13 0g
Cera Flava 30g
Make 1000 soft capsules altogether
The Folium Kaki extract, Oleum Arachidis hypogaeae semen, Cera Flava, phospholipid of getting recipe quantity are in 50 ℃ of stirred in water bath, mixing.Suspended matter is put in the colloid mill circular grinding 4 times, with gained suspension and gelatin (being offset plate or the adhesive tape made from behind gelatin and glycerol, the water dissolution) under 25 ± 2 ℃, relative humidity 40% condition, be pressed into 1000 of the soft capsules of regulation content of dispersion through automatic rotation rolling capsule machine, under 28 ± 2 ℃, relative humidity 40% condition with dry 20 hours of capsule, promptly.
Embodiment four
Folium Kaki extract 50g
PE6400 130g
Glycerol 10g
Tween?80 10g
Make 1000 soft capsules altogether
The Folium Kaki extract, PEG400, glycerol, Tween 80 of getting recipe quantity are in 50 ℃ of stirred in water bath, mixing.Suspended matter is put in the colloid mill circular grinding 2 times, with gained suspension and gelatin (being offset plate or the adhesive tape made from behind gelatin and glycerol, the water dissolution) under 25 ± 2 ℃, relative humidity 40% condition, be pressed into 1000 of the soft capsules of regulation content of dispersion through automatic rotation rolling capsule machine, under 28 ± 2 ℃, relative humidity 40% condition with dry 20 hours of capsule, promptly.
Embodiment five
Folium Kaki extract 50g
PEG400 450g
Glycerol 20g
Tween?80 20g
Make 1000 soft capsules altogether
The Folium Kaki extract, PEG400, glycerol, Tween 80 of getting recipe quantity are in 50 ℃ of stirred in water bath, mixing.With gained solution and gelatin (being offset plate or the adhesive tape made from behind gelatin and glycerol, the water dissolution) under 25 ± 2 ℃, relative humidity 40% condition, be pressed into 1000 of the soft capsules of regulation content of dispersion through automatic rotation rolling capsule machine, under 28 ± 2 ℃, relative humidity 40% condition with dry 20 hours of capsule, promptly.
Embodiment six
Folium Kaki extract 5g
PEG400 250g
Glycerol 10g
Tween?80 10g
Make 1000 soft capsules altogether
The Folium Kaki extract, PEG400, glycerol, Tween 80 of getting recipe quantity are in 50 ℃ of stirred in water bath, mixing.With gained solution and gelatin (being offset plate or the adhesive tape made from behind gelatin and glycerol, the water dissolution) under 25 ± 2 ℃, relative humidity 40% condition, be pressed into 1000 of the soft capsules of regulation content of dispersion through automatic rotation rolling capsule machine, under 28 ± 2 ℃, relative humidity 40% condition with dry 20 hours of capsule, promptly.
2, Folium Kaki extract self-emulsifying drug delivery system
The Folium Kaki extract self-emulsifying drug delivery system who the present invention relates to adopts special preparation technique that Folium Kaki extract is dissolved in the content solvent fully, take behind this dilution system spontaneous emulsification in vivo and form particle diameter below 100nm or the Emulsion of 2-2000nm, formed emulsion droplet or microemulsion in gastrointestinal tract, greatly improve medicine and gastrointestinal contact area, thereby can significantly improve the absorption rate and the degree of absorption of medicine.This medicine-releasing system can fundamentally solve the slow deficiency of Folium Kaki extract release.Reach simultaneously:
(1) absorption rate and the curative effect of raising Folium Kaki extract;
(2) purpose such as reduce production costs.
Transparent and homogeneous that the oral self-emulsifying drug delivery system of Folium Kaki extract is formed by oil phase, non-ionic surface active agent and/or co-emulsifier and the solution that comprises medicine, under the situation of ambient temperature (being generally 37 ℃) and gentle agitation, because the existence of surfactant, spontaneous emulsification forms particle diameter at 2-2000nm or the nano-emulsion below the 100nm, be called the self-emulsifying drug delivery system (self-emulsifying drug delivery systems, SMEDDS).The self-emulsifying drug delivery system who the present invention relates to, each composition is dissolved in the medicine-releasing system content with molecular forms in the Folium Kaki extract, and this medicine-releasing system can be dosage forms such as capsule, soft capsule or oral liquid.
Folium Kaki extract self-emulsifying drug delivery system's development not only has stronger social benefit, and has stronger economic benefit.
2.1, the foundation of basic prescription
2.1.1 the selection of oil phase
The mass fraction (w/w) of oil phase in self-emulsifying drug delivery system involved in the present invention is generally 0～50%; Requirement in the present invention can be with the medicine of less oil phase dissolving recipe quantity; And under the cryopreservation condition; Also do not have medicine and separate out; Meet simultaneously behind the water easily by the emulsifying agent emulsifying in the prescription.Applied in the present invention oil phase has soybean oil; Oleum Arachidis hypogaeae semen; Safflower oil; Fructus Canarii albi wet goods crude vegetal and fatty acid ester; the especially chain length medium chain fatty glyceride （ medium-chain glyceride ） between C8～C10 after the improvement.,：Arlacel 80 （ HLB＝4.3 ） Arlacel 86 （ HLB＝2.8 ） ∶ （ 90∶10 ） Capmul MCM （ HLB＝5.5～6.0 ） C8／C10Captex 200 （ oil ） C8／C10Captex 355 （ oil ） C8／C10Miglyol 812 （ oil ） C8／C10Myvacet （ oil ） Myverol 18-92 （ HLB＝3～7 ） （ 90％ ） Soybean oil （ 25％ ） （ 54％ ） Peceol （ HLB＝3 ） Maisine （ HLB＝3 ） Gelucire 44／14 （ HLB＝14 ） 。
2.1.2 the selection that emulsifying is
Adopt the nonionic emulsifier of high HLB among the present invention.The strongly hydrophilic of emulsifying agent is to form oil-in-water emulsion droplet and self emulsifying liquid immediately to spread necessaryly in aqueous environment; And it can make the self emulsifying process faster.Emulsifying agent is amphiphatic; And they itself also can dissolve a large amount of relatively hydrophobic drugs; Can prevent that medicine from depositing in gastrointestinal tract and the dissolved state of prolong drug molecule; And this is extremely important to effective absorption.What select among the present invention is emulsifying agents such as different types of liquid or solid ethyoxyl polyoxyethylene glyceride; Polyoxyethylene oleate; Tween80.Its consumption is 0～95%. is except this, and following emulsifying agent is also applicable in Nage lieqin self-emulsifying system for releasing medicine involved in the present invention: Ophase 31 (HLB=4.0) liquid egg phosphatide Cremophor EL (HLB=13.5) Emulsifier EL-60 Labrafac CM 10 (HLB=10) coconut oil C8/C10 LABRAFIL M 1944CS Labrafil M 1944 CSD (HLB=3～4) mainly be apricot kernel oil acid polyethylene glycol glyceride Labrafil M 2125 CS (HLB=3～4) mainly be apricot kernel oil acid polyethylene glycol glyceride Tagat TO (HLB=11.3) polyoxyethylene (25) glycerol trioleate Tween 80 (HLB=11.0) polyoxyethylene (20) sorbitan oleate Labrasol (HLB=14) PEG-8-glycerine sad/decylate
2.1.3 the selection of co-emulsifier
The mixture of the co-emulsifier ethylene glycol monomethyl ether (transcutol) that the present invention was suitable for, ethanol, propylene glycol, glycerol, Polyethylene Glycol (molecular weight is at 200-600), propylene carbonate (propylenecarbonate), glycerol furfural, dimethyl Soquad or above material arbitrary proportion.
2.2 Folium Kaki extract self-emulsifying drug delivery system's basic prescription
Folium Kaki extract 50
Oil phase 100
Emulsifying agent 150
Co-emulsifier 50
Make 1000 soft capsules or capsule altogether
Annotate: in A, the prescription in every capsules the amount of contained Folium Kaki extract can increase and decrease as the case may be, scope is not limit.
Folium Kaki extract in B, the prescription: oil phase: emulsifying agent: the ratio of co-emulsifier is any ratio in 1: 0～50: 0.01～200: 0.01～200 scopes.
C; used oil phase can be soybean oil in the prescription; Oleum Arachidis hypogaeae semen; safflower oil; olive oil; the medium chain fatty glyceride of chain length between C8～C10; the oleic acid sorbitol ester; olein/propylene glycol (90/10); Oleum Cocois C8/C10 monoglyceride or dibasic acid esters; Oleum Cocois C8/C10 propylene glycol dibasic acid esters; Oleum Cocois C8/C10 triglyceride; Oleum Cocois C8/C10 triglyceride; the acetylizad monoglyceride of purification; purification Oleum helianthi monoglyceride (containing 90% glyceryl linoleate); the triglyceride that contains oleic acid (25%) and linoleic acid (54%); olein; glyceryl linoleate; the mixture of wherein any or two kinds and two or more any ratio such as Polyethylene Glycol glyceryl laurate ester.
D, used emulsifying agent can be the ethyoxyl polyoxyethylene glyceride in the prescription, polyoxyethylene oleate, Tween80, lecithin, polyoxyethylene castor oil, Oleum Cocois C8/C10 polyethyleneglycol glyceride, almond oil acid polyethylene glycol glyceride, almond oil acid polyethylene glycol glyceride, polyoxyethylene (25) triolein, polyoxyethylene (20) sorbitan oleate, Polyethylene Glycol-8-glycerol is sad/mixture of wherein any or two kinds and two or more any ratio such as decanoin.
Used notes emulsifying agent can be the mixture of wherein any or two kinds and two or more any ratio such as ethylene glycol monomethyl ether (transcutol), ethanol, propylene glycol, glycerol, Polyethylene Glycol (molecular weight is at 200-600), propylene carbonate (propylene carbonate), glycerol furfural, dimethyl Soquad in E, the prescription.
Embodiment one:
It is composed as follows to write out a prescription: (g)
Folium Kaki extract 50
Ethylene glycol monomethyl ether 80
(Transcutol?P)
Tween80 250
Ethyl oleate 200
Make 1000 soft capsules altogether
Preparation technology: take by weighing the Folium Kaki extract of recipe quantity, add the ethylene glycol monomethyl ether of recipe quantity, Tween80, ethyl oleate, heating in water bath are stirred to extract and dissolve fully, treat to be pressed into capsule after medicinal liquid is reduced to room temperature.
Get 2 of Folium Kaki extract self-emulsifying soft capsule contents and stir in the 100ml distilled water, measure the emulsion droplet particle diameter with laser particle analyzer: effective grain size is 79.4nm, and poly-dispersion is 0.116.
Implement two:
It is composed as follows to write out a prescription: (g)
Folium Kaki extract 50
Laborosol 158
Glycerol 105
Maisine?35-1 80
Make 1000 soft capsules altogether
Preparation technology: take by weighing the Folium Kaki extract of recipe quantity, add the Laborosol of recipe quantity, glycerol, Maisine 35-1, heating in water bath dissolve Folium Kaki extract fully, treat to be pressed into capsule after medicinal liquid is reduced to room temperature.
Implement three:
It is composed as follows to write out a prescription: (g)
Folium Kaki extract 50
Propylene glycol 158
Tween80 205
Ethyl oleate 120
Make 1000 soft capsules altogether
Preparation technology: take by weighing the Folium Kaki extract of recipe quantity, add the propylene glycol of recipe quantity, Tween80, ethyl oleate, heating in water bath dissolve Folium Kaki extract fully, treat to be pressed into capsule after medicinal liquid is reduced to room temperature.
Implement four:
It is composed as follows to write out a prescription: (g)
Folium Kaki extract 10
Propylene glycol 88
Tween80 100
Ethyl oleate 75
Make 1000 soft capsules altogether
Preparation technology: take by weighing the Folium Kaki extract of recipe quantity, add the propylene glycol of recipe quantity, Tween80, ethyl oleate, heating in water bath dissolve Folium Kaki extract fully, treat to be pressed into capsule after medicinal liquid is reduced to room temperature.
3, soft capsule of extractive from leaves of persimmon and self-emulsifying drug delivery system's disintegration rate are investigated
With soft capsule of extractive from leaves of persimmon, the Folium Kaki extract self-emulsifying drug delivery system (is example with the soft capsule) and the comparative test of Folium Kaki extract sheet disintegration time who makes.
Test method:
According to " two appendix XII of Chinese pharmacopoeia version in 2000 A inspection technique disintegration is a medium with 37 ℃ of water, and frequency 30 times/minute is tested.
Result of the test:
Soft capsule of extractive from leaves of persimmon, Folium Kaki extract self-emulsifying drug delivery system (is example with the soft capsule) see Table 1 with the slaking test of Folium Kaki extract sheet.
Table 1 disintegration rate checkout facility result
Type of preparation 123456 is average
(min)
Soft capsule of extractive from leaves of persimmon 7.5 6.8 5.3 7.2 6.4 7.1 6.7 ± 0.8
The Folium Kaki extract self emulsifying
Medicine-releasing system is (with soft capsule 6.4 5.6 7.3 4.9 5.5 6.2 6.0 ± 0.8
Be example)
Folium Kaki extract sheet 26.0 ±
26 30 27 25 26 22
2.6
Result of the test shows, soft capsule of extractive from leaves of persimmon of the present invention, Folium Kaki extract self-emulsifying drug delivery system's external disintegration time is well below the Folium Kaki extract tablet, but for soft capsule, its disintegration time might prolong to some extent after long-term the placement, but soft capsule and self-emulsifying drug delivery systems Dissolve things inside are after discharging, content can be scattered in the gastrointestinal tract with high dispersion, makes effective ingredient by fast Absorption; And behind the disintegration of tablet, the effective ingredient in the Folium Kaki extract also must diffuse out just through dissolving, from the granule that disintegrate produces and can be absorbed, onset.
Claims (10)
1. a soft capsule of extractive from leaves of persimmon is characterized in that Folium Kaki extract is suspended in or is dissolved in soft capsule content disperse medium or the solvent.
2. soft capsule of extractive from leaves of persimmon according to claim 1 is characterized in that disperse medium or solvent that soft capsule content adopts are natural or the vegetable oil of transformation or the mixture of several oil.
3. soft capsule of extractive from leaves of persimmon according to claim 1 is characterized in that disperse medium or solvent that soft capsule content adopts are formed by main with the PEG class.
4. soft capsule of extractive from leaves of persimmon according to claim 1 is characterized in that containing in every soft capsule Folium Kaki extract 2～200mg.
5. Folium Kaki extract self-emulsifying drug delivery system, it is characterized in that comprising in this medicine-releasing system Folium Kaki extract and adjuvant, adjuvant contains emulsifying agent, co-emulsifier, oil phase or wherein two kinds, and the weight ratio of each component is: Folium Kaki extract 1～50%, adjuvant 50～99%.
6. Folium Kaki extract self-emulsifying drug delivery system according to claim 5, it is characterized in that containing emulsifying agent 1～95%, emulsifying agent can use a kind of in lecithin, polyoxyethylene (hydrogenation) Oleum Ricini, Labrafac CM 10, Labrafil M 1944 CSD, Labrafil M 2125 CS, Tagat TO, Tweens (Tween), spans (Span), these materials of Labrasol, perhaps by two or more mixture formed in these materials.
7. Folium Kaki extract self-emulsifying drug delivery system according to claim 5, it is characterized in that containing co-emulsifier 0～95%, co-emulsifier can use ethanol, propylene glycol, glycerol, Polyethylene Glycol (molecular weight is at 200-600), propylene carbonate (propylene carbonate),
A kind of in ethylene glycol monomethyl ether (transcutol), glycerol furfural, these materials of dimethyl Soquad is perhaps by two or more mixture formed in these materials.
8. Folium Kaki extract self-emulsifying drug delivery system according to claim 5 is characterized in that containing oil phase 1～50%, and oil phase is a crude vegetal, or through vegetable oil or fatty acid ester after structure of modification and the hydrolysis.
9. Folium Kaki extract self-emulsifying drug delivery system according to claim 8 is characterized in that oil phase is that chain length is at C
8～C
10Between the medium chain fatty glyceride, a kind of in these materials such as Arlacel80, Arlacel 86, Capmul MCM, Captex 200 (oil), Captex 355 (oil), Miglyol 812 (oil), Myvacet (oil), Myverol 18-92, olein, glyceryl linoleate, Polyethylene Glycol glyceryl laurate ester, ethyl oleate, Ethyl linoleate is perhaps by two or more mixture formed in these materials.
10. Folium Kaki extract self-emulsifying drug delivery system according to claim 5 is characterized in that it is a kind of dosage form that can be taken orally, and comprises various dosage forms such as capsule, soft capsule, solution.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574397B (en) * | 2009-06-12 | 2011-11-02 | 哈尔滨医科大学 | WuRenChun self-emulsifying soft capsule preparation and preparation method |
| CN101474238B (en) * | 2008-12-31 | 2012-05-23 | 四川禾邦阳光制药股份有限公司 | Persimmon leaf soft capsule preparation and preparation method thereof |
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2004
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474238B (en) * | 2008-12-31 | 2012-05-23 | 四川禾邦阳光制药股份有限公司 | Persimmon leaf soft capsule preparation and preparation method thereof |
| CN101574397B (en) * | 2009-06-12 | 2011-11-02 | 哈尔滨医科大学 | WuRenChun self-emulsifying soft capsule preparation and preparation method |
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