CN1650965A - Toosendan dipyridamole medicinal preparation and its preparation method - Google Patents
Toosendan dipyridamole medicinal preparation and its preparation method Download PDFInfo
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- CN1650965A CN1650965A CN 200410082808 CN200410082808A CN1650965A CN 1650965 A CN1650965 A CN 1650965A CN 200410082808 CN200410082808 CN 200410082808 CN 200410082808 A CN200410082808 A CN 200410082808A CN 1650965 A CN1650965 A CN 1650965A
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- dipyridamole
- herba ixeritis
- ixeritis sonchifoliae
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- extract
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- Medicines Containing Plant Substances (AREA)
Abstract
A medicine in the form of injection or others for treating coronary heart disease, cerebral thrombus, angina pectoris and eyeground diseases is prepared from the extract of sowthistleleaf ixeris herb and dipyridamole.
Description
Technical field:
The invention provides a kind of Herba Ixeritis Sonchifoliae dipyridamole pharmaceutical preparation and preparation method thereof, belong to the technical field of medicine and preparation method thereof.
Background technology:
Herba Ixeritis Sonchifoliae belongs to feverfew, has another name called Herba Ixeritis Sonchifoliae.With all herbal medicine.Its main medicinal ingredient is flavone and adenosine.Because contained plant flavone and the adenosine of Herba Ixeritis Sonchifoliae coexists, so have significant effect for the treatment of cardiovascular and cerebrovascular disease.By pharmacodynamics and clinical being verified.At present, be indicated in commercially available Herba Ixeritis Sonchifoliae preparation DIEMAILING ZHUSHEYE is arranged.Its pharmacological action is: the myocardial ischemia that increase coronary flow, reduce coronary vascular resistance, blood pressure regulation, antagonism pituitrin causes, reduce myocardial oxygen consumption, anti-myocardial infarction, increase collateral circulation, improve the heart microcirculation; Antiplatelet aggregation, increase fibrinoclase activity, inhibition thrombosis; Expansion optical fundus arteries improves the visual disorder due to the circulatory disturbance.But also there is serious deficiency in the application of this medicine: the DIEMAILING ZHUSHEYE poor stability, and the storage time is short, and there are a large amount of losses in two kinds of effective ingredient of flavone and adenosine in producing and storing, had a strong impact on result of use; Dosage form is single, can not satisfy clinical multifaceted application; Drug action is not outstanding, though the effect of coronary artery dilator is arranged, a little less than the effect of antiplatelet aggregation, and onset is slow.At the problems referred to above, the spy has developed the pharmaceutical preparation of Herba Ixeritis Sonchifoliae dipyridamole.Two kinds of medicines are made into compound preparation, have both kept original drug action of Herba Ixeritis Sonchifoliae, increased the anticoagulant that dipyridamole has again, suppress myocardial cell PDA activity, suppress thromboxane A2, strengthened the effect of endogenous PGI2.Improved drug action significantly.And the injection of this medicine, the various dosage forms of oral agents have been made.Consult domestic and foreign literature, still do not see any report and the patent application of Herba Ixeritis Sonchifoliae dipyridamole compound preparation.
Summary of the invention:
The object of the invention: the pharmaceutical preparation of a kind of compound recipe Herba Ixeritis Sonchifoliae dipyridamole is provided.For the clinical treatment cardiovascular and cerebrovascular disease provides a kind of safe, efficient, novel medicament.
The present invention constitutes like this: the pharmaceutical preparation of compound recipe Herba Ixeritis Sonchifoliae dipyridamole, be prepared from by Herba Ixeritis Sonchifoliae extract and dipyridamole, the consumption of two kinds of components (by adult's consumption every day) is: Herba Ixeritis Sonchifoliae extract is equivalent to crude drug 0.01g-1000g, optimised quantity 0.5g-500g.Dipyridamole raw material 1-5000mg, optimised quantity 1mg-300mg, the dosage form of compound recipe Herba Ixeritis Sonchifoliae dipyridamole pharmaceutical preparation has: injection, various peroral dosage form, suppository.Various percutaneous dosing dosage forms.Wherein the most frequently used with the above-mentioned dosage form of injection, injectable powder, infusion solutions, tablet, capsule, granule, oral liquid, drop pill and employing slow release, controlled release, the preparation of dispersible preparation method.Preparation technology provided by the present invention: at first Herba Ixeritis Sonchifoliae is added certain water gaging, decoction, coarse filtration, microfiltration, be concentrated into every 1ml and be equivalent to crude drug in whole 0.5g, through cooling, stirring, filtration, in the 5.5 times of ethanol that more above-mentioned precipitate suspended, transfer PH, filtration with hydrochloric acid acid, from filtrate, reclaim ethanol, adding the injection water makes every 1ml and is equivalent to crude drug in whole 4g, add activated carbon, boiled 15 minutes, and placed 4 ℃ to transfer again 24 hours, filter, transfer PH to 7, reuse cardboard, sintered filter funnel, filtering with microporous membrane are made Herba Ixeritis Sonchifoliae extract.Get the said extracted thing and add the dipyridamole raw material in given ratio, add stabilizing agent, proppant, stir, make it to dissolve fully, subsequent technique is made into injection, freeze-dried powder, infusion solutions, oral liquid, tablet, capsule, granule, drop pill by prior art.
The pharmaceutical preparation of compound recipe Herba Ixeritis Sonchifoliae dipyridamole, it cures mainly function and is blood vessel dilating, anticoagulant, the supply of improvement cardiac muscle blood oxygen, increase fibrinoclase activity, inhibition thrombosis.Be used for coronary heart disease, angina pectoris, cerebral thrombosis, fundus oculi disease.
Advantage of the present invention is: the effective ingredient in the Herba Ixeritis Sonchifoliae dipyridamole is made into compound preparation, has overcome the limitation that single medicine is used, obviously improved the therapeutic effect to cardiovascular and cerebrovascular disease, guaranteed safety of clinical administration, convenience, effective, quality controllable.
Embodiment:
The present invention prepares example
The preparation of Herba Ixeritis Sonchifoliae extract: get Herba Ixeritis Sonchifoliae 50kg, add 3-5 times of water, decocted 3 hours, with the decoction liquor coarse filtration, microfiltration is concentrated into every 1ml and is equivalent to crude drug in whole 0.5g.Concentrated solution is cooled to below 40 ℃, stirs, add content and be 5% sodium oxide, transfer PH to 10, filter, precipitate is weighed.Above-mentioned precipitate is suspended in 5.5 times of ethanol, adds concentration and transfer PH to 4 for 5-10% hydrochloric acid, fully stir, filter, adding content again in filtrate is 40% sodium hydroxide solution, transfers PH to 7.2, filters, and filtrate recycling ethanol is also waved most ethanol.Add the injection water and make every 1ml and be equivalent to crude drug in whole 4g, put 4 ℃ of cold preservations 12 hours, filter, add 0.1% activated carbon, boiled 15 minutes, placed 24 hours down in 4 ℃ again, filter, transfer PH to 7, reuse cardboard, sintered filter funnel, filtering with microporous membrane are made Herba Ixeritis Sonchifoliae extract solution or powder.
Embodiment 1: Herba Ixeritis Sonchifoliae dipyridamole injection liquid: (1000)
Get above-mentioned Herba Ixeritis Sonchifoliae extracting solution 10000ml, add dipyridamole raw material (injection stage) 4g, stir, fully dissolving was boiled 30 minutes.Transfer PH to 6.5-7.0 with hydrochloric acid, filter, subsequent technique becomes injection by prior art for preparing.
Embodiment 2: Herba Ixeritis Sonchifoliae dipyridamole lyophilized powder (1000)
Get above-mentioned Herba Ixeritis Sonchifoliae extracting solution 10000ml, add dipyridamole raw material (injection stage) 4g, stir, fully dissolving was boiled 30 minutes, transferred PH6.5-7.0 with hydrochloric acid, filtered, and made freeze-dried powder by there being technology to make
Embodiment 3: Herba Ixeritis Sonchifoliae dipyridamole infusion solutions (1000 bottles)
Get above-mentioned Herba Ixeritis Sonchifoliae extracting solution 20000ml, add dipyridamole raw material 8g, stir, dissolving was boiled 30 minutes fully, added sterile water solution to 25 ten thousand ml, transferred PH6.5-7.0 with hydrochloric acid, filtered, and was made into infusion solutions by prior art.
Embodiment 4, Herba Ixeritis Sonchifoliae dipyridamole oral liquid (1000 * 20ml)
Get above-mentioned Herba Ixeritis Sonchifoliae extracting solution 20000ml, add dipyridamole raw material 25g, fully stir, filter, become oral liquid by prior art for preparing.
Embodiment 5, Herba Ixeritis Sonchifoliae dipridamole (1000)
Get above-mentioned Herba Ixeritis Sonchifoliae extracting solution 20000ml, add dipyridamole raw material 25g, add right amount of auxiliary materials, be made as tablet by prior art.
Embodiment 6, Herba Ixeritis Sonchifoliae dipyridamole capsule (1000)
Get above-mentioned Herba Ixeritis Sonchifoliae extracting solution 20000ml, add dipyridamole raw material 25g, add right amount of auxiliary materials, be made as capsule by prior art.
Embodiment 7, Herba Ixeritis Sonchifoliae dipyridamole granulate agent (2000 bags)
Get above-mentioned Herba Ixeritis Sonchifoliae extracting solution 20000ml, add dipyridamole raw material 25g, add right amount of auxiliary materials, be made as granule by prior art.
Claims (5)
1, a kind of compound recipe Herba Ixeritis Sonchifoliae dipyridamole pharmaceutical preparation, it is characterized in that: it is prepared from by Herba Ixeritis Sonchifoliae extract, dipyridamole.The quantity relative ratio relationship of two kinds of components (by adult's consumption every day) is: Herba Ixeritis Sonchifoliae extract is equivalent to crude drug in whole 0.01-1000g, dipyridamole 1-5000mg.
2, according to the pharmaceutical preparation of the said Herba Ixeritis Sonchifoliae dipyridamole of claim 1, it is characterized in that: two kinds of preferred proportionings of component are: Herba Ixeritis Sonchifoliae extract is equivalent to crude drug in whole 0.5-500g, dipyridamole 1-300mg.
3, according to the pharmaceutical preparation of the said Herba Ixeritis Sonchifoliae dipyridamole of claim 1, it is characterized in that: the dosage form of this pharmaceutical preparation is injection, various peroral dosage form, suppository, various percutaneous dosing dosage form.Common formulations is injection, freeze-dried powder, infusion solutions, tablet, capsule, granule, drop pill and oral liquid.And the above-mentioned dosage form that adopts slow release, controlled release, dispersion technology preparation.
4, according to the manufacture method of the medicine of the said Herba Ixeritis Sonchifoliae dipyridamole of claim 3, it is characterized in that: it is the extract that Herba Ixeritis Sonchifoliae is made into certain content, add the dipyridamole raw material according to given ratio, add suitable adjuvant and water for injection, subsequent technique is to be made into finished product according to prior art.
5, according to the manufacture method of the said Herba Ixeritis Sonchifoliae dipyridamole of claim 4 medicine, it is characterized in that: in manufacturing process, the adjuvant of interpolation is cosolvent, solubilizing agent, stabilizing agent, excipient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410082808 CN1650965A (en) | 2004-11-30 | 2004-11-30 | Toosendan dipyridamole medicinal preparation and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410082808 CN1650965A (en) | 2004-11-30 | 2004-11-30 | Toosendan dipyridamole medicinal preparation and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1650965A true CN1650965A (en) | 2005-08-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410082808 Pending CN1650965A (en) | 2004-11-30 | 2004-11-30 | Toosendan dipyridamole medicinal preparation and its preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7588784B2 (en) * | 2007-10-05 | 2009-09-15 | Attila Mady | Use of onion extracts to prevent and treat acute and chronic cardiac and vascular complications and their sequelae, as well as to resolve hematomas |
-
2004
- 2004-11-30 CN CN 200410082808 patent/CN1650965A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7588784B2 (en) * | 2007-10-05 | 2009-09-15 | Attila Mady | Use of onion extracts to prevent and treat acute and chronic cardiac and vascular complications and their sequelae, as well as to resolve hematomas |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |