CN1631558A - Method for reclaiming dimethyl acetamide from cefoperazone sodium production waste liquid - Google Patents
Method for reclaiming dimethyl acetamide from cefoperazone sodium production waste liquid Download PDFInfo
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- CN1631558A CN1631558A CN 200410044152 CN200410044152A CN1631558A CN 1631558 A CN1631558 A CN 1631558A CN 200410044152 CN200410044152 CN 200410044152 CN 200410044152 A CN200410044152 A CN 200410044152A CN 1631558 A CN1631558 A CN 1631558A
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- waste liquid
- cefoperazone sodium
- dimethylacetylamide
- under vacuum
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Abstract
This is about the way to recycle ammonia in the waster liquid, which concerns the way to recycle ammonia in the waster liquid in producing medicine. In its producing, there is much waste liquid including ammonia. For it contains much ammonia and its much poison, the waster water can not go in the waster water handling factory. The recycling way of the invention is: decrease press; put the waste liquid into the tower and separate it, we get light part, and then go on heating, then we get the ammonia. The pure degree in this way can achieve above 90%. By this way, we not only decrease the environment pollution by waster liquid, but also we can save resources, and bring much performance to the business enterprise, so it has very good foreground of application.
Description
Technical field:
The present invention relates to a kind of method that in pharmaceutical waste liquor, reclaims dimethylacetylamide.
Background technology:
Cefoperazone sodium (also claiming Xianfengbisu) is the semi-synthetic cynnematin of third generation wide spectrum, this medicine is one of best medicine of antibacterial effect in the present cephalosporin analog antibiotic, the cefoperazone sodium of domestic use of past relies on import always, the beginning of this century, domestic some large-scale pharmaceutical factory began trial production, now formally realized production domesticization.Cefoperazone sodium produces the waste liquid that contains dimethylacetylamide in a large number in the middle workshop section of its production, because dimethylacetylamide content height and toxicity are big, causes this waste liquid can not directly enter the sewage treatment plant in pharmaceutical factory.Do not have still at present both at home and abroad that this kind cefoperazone sodium produces that waste liquid is effectively handled or from wherein reclaiming the report of dimethylacetylamide method.
Summary of the invention:
The object of the present invention is to provide a kind of method of effectively producing recovery dimethylacetylamide the waste liquid from cefoperazone sodium, its recovery method is: rectification under vacuum: cefoperazone sodium is produced waste liquid send into the rectification under vacuum tower and separate, can at first isolate light component in the waste liquid at cat head by rectification under vacuum, continue to heat up, can be from cat head extraction finished product dimethylacetylamide.The rectification under vacuum method is a kind of conventional method, but this method is used to reclaim on the dimethylacetylamide beyond example, the present inventor finds, utilize this method to produce and reclaim out dimethylacetylamide the waste liquid from cefoperazone sodium, and the purity of the dimethylacetylamide that is reclaimed can reach national technical grade product standard, and the rate of recovery of dimethylacetylamide can reach more than 90%.Utilize the method for the invention not only can alleviate the environmental pollution that waste liquid causes, and can save resource, and, have good popularizing application prospect for enterprise brings good economic benefit.
The specific embodiment:
The specific embodiment one: the recovery method of present embodiment is: rectification under vacuum: cefoperazone sodium is produced waste liquid send into the rectification under vacuum tower and separate, can at first isolate light component in the waste liquid at cat head by rectification under vacuum, continue to heat up, can be from cat head extraction finished product dimethylacetylamide.
The specific embodiment two: the recovery method of present embodiment is, cefoperazone sodium is produced waste liquid send into the rectification under vacuum tower and carry out rectifying, the pressure of system is 0.095Mpa, and column bottom temperature is controlled at below 95 ℃, when tower top temperature is 27～65 ℃, isolate light component impurity the waste liquid from cat head; When tower top temperature is 68 ℃, get final product the extraction mass fraction at the finished product dimethylacetylamide more than 96% from cat head.Column bottom temperature is controlled at can prevent refuse generation chemical reaction at the bottom of the tower below 95 ℃, bring interference for the separation of dimethylacetylamide.
Claims (2)
1. produce the method that reclaims dimethylacetylamide the waste liquid from cefoperazone sodium for one kind, the recovery method that it is characterized in that it is: rectification under vacuum: cefoperazone sodium is produced waste liquid send into the rectification under vacuum tower and separate, can at first isolate light component in the waste liquid at cat head by rectification under vacuum, continue to heat up, can be from cat head extraction finished product dimethylacetylamide.
2. method of producing recovery dimethylacetylamide the waste liquid according to claim 1 from cefoperazone sodium, it is characterized in that cefoperazone sodium is produced waste liquid to be sent into the rectification under vacuum tower and carry out rectifying, the pressure of system is 0.095Mpa, column bottom temperature is controlled at below 95 ℃, when tower top temperature is 27～65 ℃, isolate light component impurity the waste liquid from cat head; When tower top temperature is 68 ℃, get final product the extraction mass fraction at the finished product dimethylacetylamide more than 96% from cat head.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100441528A CN100342986C (en) | 2004-12-22 | 2004-12-22 | Method for reclaiming dimethyl acetamide from cefoperazone sodium production waste liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100441528A CN100342986C (en) | 2004-12-22 | 2004-12-22 | Method for reclaiming dimethyl acetamide from cefoperazone sodium production waste liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1631558A true CN1631558A (en) | 2005-06-29 |
| CN100342986C CN100342986C (en) | 2007-10-17 |
Family
ID=34845980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100441528A Expired - Fee Related CN100342986C (en) | 2004-12-22 | 2004-12-22 | Method for reclaiming dimethyl acetamide from cefoperazone sodium production waste liquid |
Country Status (1)
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| CN (1) | CN100342986C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088951A1 (en) * | 2010-12-28 | 2012-07-05 | 南京工业大学 | Process for recovering vehicle in pharmaceutical industry |
| CN103145577A (en) * | 2013-02-25 | 2013-06-12 | 天津天中福大科技发展有限公司 | Method and equipment for recycling dimethylacetamide from waste pharmaceutical liquor and thermal coupling method |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB814271A (en) * | 1956-08-10 | 1959-06-03 | Union Carbide Corp | Method for the purification of n,n-dimethylacetamide |
| DE1669559A1 (en) * | 1966-08-23 | 1971-01-28 | Schwarza Chemiefaser | Process for the regeneration of solvents used for the production of solutions from polyacrylonitrile |
| GB1165278A (en) * | 1966-12-15 | 1969-09-24 | Du Pont | Separation of Dimethylacetamide from Mixtures by Distillation |
| DE2631734B2 (en) * | 1976-07-15 | 1978-11-30 | Bayer Ag, 5090 Leverkusen | Process for the recovery of dimethylac) amides |
| JPS6193147A (en) * | 1984-10-15 | 1986-05-12 | Daicel Chem Ind Ltd | Method of purifying n-dimethylacetamide |
| DE10315214A1 (en) * | 2003-04-03 | 2004-10-14 | Basf Ag | Process for the purification of dimethylacetamide (DMAC) |
-
2004
- 2004-12-22 CN CNB2004100441528A patent/CN100342986C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088951A1 (en) * | 2010-12-28 | 2012-07-05 | 南京工业大学 | Process for recovering vehicle in pharmaceutical industry |
| CN103145577A (en) * | 2013-02-25 | 2013-06-12 | 天津天中福大科技发展有限公司 | Method and equipment for recycling dimethylacetamide from waste pharmaceutical liquor and thermal coupling method |
| CN103145577B (en) * | 2013-02-25 | 2014-08-27 | 天津天中福大科技发展有限公司 | Method and equipment for recycling dimethylacetamide from waste pharmaceutical liquor and thermal coupling method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100342986C (en) | 2007-10-17 |
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