CN1631457A - Porous compound material capable of implanting to human body to develop and its preparation method - Google Patents
Porous compound material capable of implanting to human body to develop and its preparation method Download PDFInfo
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- CN1631457A CN1631457A CN 200510000581 CN200510000581A CN1631457A CN 1631457 A CN1631457 A CN 1631457A CN 200510000581 CN200510000581 CN 200510000581 CN 200510000581 A CN200510000581 A CN 200510000581A CN 1631457 A CN1631457 A CN 1631457A
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Abstract
The invention provides a porous compound material capable of implanting to human body with development function, which comprises medical macromolecular material and developing inorganic material with the weight ratio of 85-30:15-70, the factor of porosity of the porous medical composite material is 30-70%, the bore diameter is 100-500 um, the grain diameter of the development inorganic material is 20nm-1mm. The invention also discloses the process for preparing the material.
Description
Technical field
The present invention relates to a kind of medical material, particularly a kind of implantable porous medical macromolecular materials composite and preparation method thereof that develops.
Background technology
At present, be widely used in orthopaedics and embedded material orthopedic, orthopedic clinical mostly is porous medical macromolecular materials embedded material, as ultra-high molecular weight polyethylene, high density polyethylene (HDPE), the porous medical macromolecular materials embedded material of medical macromolecular materials materials such as polypropylene preparation, because its plasticity is big, can be prepared into the artificial bone of arbitrary shape porous body and be widely used.But these porous medical macromolecular materials embedded material density are lower than water, therefore implanting the back all can not develop when checking with x light or the conventional development of x-CT, change of shape and the displacement situation that can not represent its postoperative, this brings very big inconvenience for the tracing observation and the corresponding medical research of postoperative.
Summary of the invention
The implantable porous medical macromolecular materials composite that can develop when technical problem to be solved by this invention provides a kind of available conventional x light or the inspection of x-CT inspection method, and have preferably and biocompatibility, the method for this composite of preparation also will be provided for this reason.
For solving this technical problem, the technical solution used in the present invention is:
The porous medical composite material that a kind of implantable body can develop, the inorganic material that includes medical macromolecular materials and can develop, medical macromolecular materials are 85～30: 15～70 with the weight ratio of the inorganic material that can develop, described porous medical composite material porosity is 30%～70%, the aperture is 100 μ m～500 μ m, the described inorganic material particle diameter that develops is 20nm～1mm, the inorganic material that can develop is compounded in the medical macromolecular materials surface, or evenly be compounded in medical macromolecular materials inside, or on the surface of medical macromolecular materials, inner simultaneously compound.
Described medical macromolecular materials are ultra-high molecular weight polyethylene, high density polyethylene (HDPE), polypropylene, Merlon or silicone rubber; Described inorganic material of developing is hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate; Described medical macromolecular materials are 1～4: 1 with the weight ratio preferable range of the inorganic material that can develop.
Medical macromolecular materials have following three kinds with the complex method of the inorganic material that can develop:
1, the inorganic material that can develop is compounded in the preparation process on medical macromolecular materials surface and is:
A, the medical macromolecular materials of 30～85 weight portions are prepared into the aperture is 100～500 μ m, and porosity is 30%～70% required form porous body;
B, be that the inorganic material of developing of 20nm～1mm evenly covers the porous body surface, and thermoplastic is compound, makes the inorganic material that can develop attached to the porous body surface with the particle diameter of 70～15 weight portions.
Described b step is: the compound inorganic material of developing of method of the porous body surface in a step being utilized chemical deposition.
2, the inorganic material that can develop evenly is compounded in the preparation method of medical macromolecular materials inside and is: this preparation method comprises the steps:
A, the medical macromolecular materials of 85～30 weight portions being heated to molten molten state, is that the inorganic material that 20nm～1mm can develop is fully mixed with the particle diameter of 15～70 weight portions;
B, the spheroidal particle that particle diameter is 0.1mm～1mm is made in the mixture compression moulding among a;
C, the spheroidal particle sintering among the b is made porosity is 30%～70%, and the aperture is the composite porous of 100～500 μ m.
3, the preparation method of the compound and inner even composite medical macromolecular material of the inorganic material surface that can develop is: this preparation method comprises the steps:
A, be that 85～30: 15～70 medical macromolecular materials fully mix with inorganic material after the spheroidal particle that particle diameter is 0.1mm～1mm is made in compression moulding with weight ratio.
B, the granule sintering in a step is made the aperture is 100-500 μ m, and porosity is 30～70% required form porous body, and with the method surface recombination inorganic material of chemical deposition.
Described b step is: with particle diameter is that the inorganic material of developing of 20nm～1mm evenly covers the porous body surface, and thermoplastic is compound.
The beneficial effect that the present invention produced is: the porous medical macromolecular materials composite implantation material by the present invention preparation had both had can be implanted afterwards at conventional x x ray fluoroscopy x, during CT examination, can develop helps carrying out the advantage of pathological analysis, have again implant the back since material surface compound the advantage that makes the convalescence shortening after the implantation with the better inorganic bio of human body affinity.Manufacturing process of the present invention is simple, and cost is low, does not have industrial pollution.
The specific embodiment
Embodiment 1
The aperture is 100-200 μ m, and porosity is 35% the thick thin slice shape porous composite implantation material of 1.5mm, adopts the method for the inner compound inorganic material of developing.
Preparation raw material: hydroxyapatite (perhaps β tricalcium phosphate, calcium carbonate and calcium sulfate, barium sulfate), silicone rubber
Preparation method:
A, the silicone rubber of 85 weight portions is put into banbury be heated to molten molten state;
B, be that hydroxylapatite powder and the silicone rubber of 100nm fully mixes with 15 weight portion granularities;
C, the mixture in the b step is made the spheroidal particle that mean diameter is 0.15mm through compression moulding, and then sintering to make the aperture be 100-200 μ m, porosity is 35% the thick thin slice shape porous composite implantation material of 1.5mm.
This material can be used for the position of the big plasticity of needs, as: eye socket and upper jaw bone,, do under the 220mA condition in the Cranial Computed Tomography inspection and develop obviously at 120KV with the multi-layer helical scanning computed tomography.
Inorganic developing material β tricalcium phosphate, calcium carbonate and calcium sulfate or barium sulfate are identical with the said method step with the preparation method of the inner compound tense of silicone rubber.
Embodiment 2
The aperture is 300～400 μ m, and porosity is the flaky porous medical macromolecular materials composite of 50% the compound β tricalcium phosphate of surperficial compression moulding.
Raw material: hydroxyapatite (perhaps β tricalcium phosphate), ultra-high molecular weight polyethylene (or high density polyethylene (HDPE))
Preparation method:
A, the ultra-high molecular weight polyethylene of 70 weight portions is made the thick aperture of 2mm earlier is 300～400 μ m, and porosity is 50% porous thin slice,
B, then the hydroapatite particles of the about 500nm of particle diameter of 30 weight portions was carried out thermoplastic compound 10 minutes under the pressure of 140 ℃ and 10MPa, be prepared into and contain β tricalcium phosphate porous medical macromolecular materials composite implantation material.
This material can be used for the moderate position of plasticity, as skull, implants the back and all develops obviously in x x ray fluoroscopy x and the conventional medical inspection of CT.
The preparation method of the composite of β tricalcium phosphate and high density polyethylene (HDPE) is identical with the preparation method of the composite of hydroxyapatite and high density polyethylene (HDPE).
Embodiment 3
The aperture is 400-500 μ m, and porosity is 65%, and diameter is the spherical porous medical composite material of φ 20mm, adopts inorganic material and medical macromolecular materials surface chemistry deposition and inner composite methods simultaneously.
Raw material: high density polyethylene (HDPE), hydroxyapatite, lime nitrate, diammonium phosphate
Preparation method:
A, be that the hydroxyapatite powder of 50nm fully mixes under the molten molten state of high density polyethylene (HDPE) with the high density polyethylene (HDPE) that weight is about 50 weight portions with the particle diameter of 45 weight portions,
B, the mixture among a is made the spheroidal particle that mean diameter is 0.5mm, and then to make the aperture be 400-500 μ m, porosity is that 65% diameter is the spheroid of φ 20mm,
C, spheroid is immersed in the calcium nitrate solution of 0.05mol-1mol, through and equivalent or slightly excessive diammonium phosphate reaction, make the compound nano-grade hydroxy apatite of 5 weight portions on the outer surface of its porous spheroid.
This material is implanted the back and all can be developed in x x ray fluoroscopy x and CT examination.
Claims (8)
1, the porous medical composite material that a kind of implantable body can develop, the inorganic material that includes medical macromolecular materials and can develop, it is characterized in that: medical macromolecular materials are 85～30: 15～70 with the weight ratio of the inorganic material that can develop, described porous medical composite material porosity is 30%～70%, the aperture is 100 μ m～500 μ m, the described inorganic material particle diameter that develops is 20nm～1mm, the inorganic material that can develop is compounded in the medical macromolecular materials surface, or evenly be compounded in medical macromolecular materials inside, or on the surface of medical macromolecular materials, inner simultaneously compound.
2, a kind of implantable body according to claim 1 porous medical composite material that can develop, it is characterized in that: described medical macromolecular materials are ultra-high molecular weight polyethylene, high density polyethylene (HDPE), polypropylene, Merlon or silicone rubber; Described inorganic material of developing is hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate.
3, according to claim 1 a kind of develop can implantable porous medical macromolecular materials composite, it is characterized in that: described medical macromolecular materials are 1～4: 1 with the weight ratio preferable range of the inorganic material that can develop.
4, the preparation method of a kind of implantable body porous medical composite material that can develop, it is characterized in that: the preparation process that the inorganic material that can develop is compounded in the medical macromolecular materials surface is:
A, the medical macromolecular materials of 30～85 weight portions are prepared into the aperture is 100～500 μ m, and porosity is 30%～70% required form porous body;
B, be that the inorganic material of developing of 20nm～1mm evenly covers the porous body surface, and thermoplastic is compound, makes the inorganic material that can develop attached to the porous body surface with the particle diameter of 70～15 weight portions.
5, the preparation method of a kind of implantable body according to claim 4 porous medical composite material that can develop, it is characterized in that: described b step is: the compound inorganic material of developing of method of the porous body surface in a step being utilized chemical deposition.
6, the preparation method of a kind of implantable body porous medical composite material that can develop, it is characterized in that: the preparation method that the inorganic material that can develop evenly is compounded in medical macromolecular materials inside is:
This preparation method comprises the steps:
A, the medical macromolecular materials of 85～30 weight portions being heated to molten molten state, is that the inorganic material that 20nm～1mm can develop is fully mixed with the particle diameter of 15～70 weight portions;
B, the spheroidal particle that particle diameter is 0.1mm～1mm is made in the mixture compression moulding among a;
C, the spheroidal particle sintering among the b is made porosity is 30%～70%, and the aperture is the composite porous of 100～500 μ m.
7, the preparation method of a kind of implantable body porous medical composite material that can develop is characterized in that: the compound and inner evenly preparation method of composite medical macromolecular material of the inorganic material surface that can develop is: this preparation method comprises the steps:
A, be that 85～30: 15～70 medical macromolecular materials fully mix with inorganic material after the spheroidal particle that particle diameter is 0.1mm～1mm is made in compression moulding with weight ratio.
B, the granule sintering in a step is made the aperture is 100-500 μ m, and porosity is 30～70% required form porous body, and with the method surface recombination inorganic material of chemical deposition.
8, the preparation method of a kind of implantable body according to claim 7 porous medical composite material that can develop, it is characterized in that: described b step is: with particle diameter is that the inorganic material of developing of 20nm～1mm evenly covers the porous body surface, and thermoplastic is compound.
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| CNB200510000581XA CN100337695C (en) | 2005-01-10 | 2005-01-10 | Porous compound material capable of implanting to human body to develop and its preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101668552B (en) * | 2007-02-26 | 2013-07-31 | 瑞典树木科技公司 | Implantable material comprising cellulose and glycopeptides xyloglucan-GRGDS |
| CN103948968A (en) * | 2014-05-13 | 2014-07-30 | 天津德岩科技有限公司 | In-vivo implanted composite material with X-ray developing performance and preparation method of in-vivo implanted composite material |
| CN104861303A (en) * | 2015-06-12 | 2015-08-26 | 福路明精密管材（北京）有限公司 | Medical polypropylene composite material and preparation method thereof |
| CN108250712A (en) * | 2018-02-28 | 2018-07-06 | 成都普特斯医疗科技有限公司 | A kind of medical polycarbonate composite material and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5210130A (en) * | 1990-08-07 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Homogeneous, high modulus ultrahigh molecular weight polyethylene composites and processes for the preparation thereof |
| CN1221292C (en) * | 2002-11-21 | 2005-10-05 | 北京市意华健科贸有限责任公司 | Prep. of composite hydroxyapatite-ultrahigh molecular weight polyethylene sclerite |
| CN100366301C (en) * | 2003-12-03 | 2008-02-06 | 北京市意华健科贸有限责任公司 | Coral hydroxyapatite artificial bone with betatype tricalcium phosphate coating and its preparation |
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2005
- 2005-01-10 CN CNB200510000581XA patent/CN100337695C/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101668552B (en) * | 2007-02-26 | 2013-07-31 | 瑞典树木科技公司 | Implantable material comprising cellulose and glycopeptides xyloglucan-GRGDS |
| CN103948968A (en) * | 2014-05-13 | 2014-07-30 | 天津德岩科技有限公司 | In-vivo implanted composite material with X-ray developing performance and preparation method of in-vivo implanted composite material |
| CN103948968B (en) * | 2014-05-13 | 2019-02-19 | 天津德岩科技有限公司 | Et al. Ke composite material and preparation method with X-ray developing performance |
| CN104861303A (en) * | 2015-06-12 | 2015-08-26 | 福路明精密管材（北京）有限公司 | Medical polypropylene composite material and preparation method thereof |
| CN108250712A (en) * | 2018-02-28 | 2018-07-06 | 成都普特斯医疗科技有限公司 | A kind of medical polycarbonate composite material and preparation method thereof |
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| CN100337695C (en) | 2007-09-19 |
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