CN1631373A - Enteric coated formulation of Coriolus Versicolor Polysaccharide and its preparation process - Google Patents
Enteric coated formulation of Coriolus Versicolor Polysaccharide and its preparation process Download PDFInfo
- Publication number
- CN1631373A CN1631373A CN 200410065405 CN200410065405A CN1631373A CN 1631373 A CN1631373 A CN 1631373A CN 200410065405 CN200410065405 CN 200410065405 CN 200410065405 A CN200410065405 A CN 200410065405A CN 1631373 A CN1631373 A CN 1631373A
- Authority
- CN
- China
- Prior art keywords
- krestin
- enteric
- preparation
- coated
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention provides an enteric coated formulation of Coriolus Versicolor Polysaccharide and its preparation process, which converts the conventional oral administration preparation into intestine dissolvable preparation, decreases the disintegration of the medicament in stomach. The preparation is prepared from egg white sweets extracted from the mycelium of Basidiomycetes, pore fungus, Coriolus Versicolor Polysaccharide fruiting body as the main available compositions. The dosage form of the preparation includes enteric coated tablet, enteric-coated micro granules, enteric coated thin film tablet, enteric-coated capsule, timing release tablet, microporous membrane dressing tablet, controlled micro granules, microballoon, microcapsule, and solid or liquid preparation prepared from enteric coated particles.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of enteric coated formulation of Coriolus Versicolor Polysaccharide and preparation method thereof specifically.
Background technology
Krestin is from Basidiomycetes (Basidiomyctes), Polyporaceae (Polyporaceae), Coriolous Dersicolor (Fr.) Quel (polystictusversicalor (L.) Fr) sporophore and solid culture, the proteoglycan that extracts in the mycelium of liquid culture.At present, clinical many with manyzoned polypore sporophore and solid culture, the extract for treating chronic hepatitis B in the mycelium of liquid culture reaches the immunotherapy medication of the cancer at positions such as digestive system, respiratory system and cervix uteri, mammary gland.Common dosage form has syrup, electuary, and tablet, conventional oral formulations such as capsule, the untoward reaction of seeing is a digestive tract reaction more, and especially to feel sick, belch is the most common, and many patients influence appetite because of the bad smell of belch, even are reluctant to continue to take.The clinical statistics data shows have 30-60% that gastrointestinal upset is arranged among the patient that takes medicine, and 20-35% has significantly and feels sick, the belch symptom, and the patient that 5-10% arranged is because of being impatient at this untoward reaction krestin of stopping using.By research, we find, the gastrointestinal side effect of this medicine is mainly relevant with the nature and flavor of the extraction process of polysaccharide and extract.Krestin extracts raw material and mostly is liquid fermentation liquid or mycelium, and by the aqueous extraction-alcohol precipitation technology preparation, extract has special abnormal smells from the patient.When oral formulations under one's belt during the disintegrate stripping, residual ethanol abnormal smells from the patient has constituted the source of belch bad smell in the special odor of extract and the extract.Oral conventional formulation disintegration time in gastric juice was generally within 10 minutes, and 45 minutes dissolution is about 85%, and quality standard requires more than 75%.
Summary of the invention
The present invention is directed to the common dosage form of krestin and have above problem, a kind of enteric coated formulation of Coriolus Versicolor Polysaccharide is provided, change original conventional oral formulations into enteric coated preparation, reduced medicine disintegrate under one's belt,, eliminate the generation of gastrointestinal side effect to alleviate.
Another object of the present invention provides the preparation method of krestin preparation.
A kind of enteric coated formulation of Coriolus Versicolor Polysaccharide, it is with from Basidiomycetes, Polyporaceae, manyzoned polypore sporophore and solid culture, and the proteoglycan that extracts in the mycelium of liquid culture is main effective ingredient, its preparation comprises enteric coatel tablets, enteric coated micropill, enteric diaphragm, enteric coated capsule, timed release tablet, microporous membrane coated tablet, control micropill, microsphere, microcapsule, enteric core matrix, and solid or the liquid preparation made with enteric-coated microsome.
Wherein the proteoglycan that is extracted is for process is refining, the krestin extract of purification, the content of its krestin is pressed dry product weight and is calculated, and contains total sugar with glucose meter, is not less than 45% (percentage by weight), contain peptide in bovine serum albumin, be no less than 25% (percentage by weight).
The preparation method of krestin enteric coatel tablets is mixed krestin with starch supplementary material, ethanol, water are fountain solution, wet granulation, and tabletting, label bag one deck contagion gown, it is enteric coated to dry up the back.
Krestin mixes with starch supplementary material, and ethanol, water are fountain solution, make micropill, micropill bag one deck contagion gown, and dry back is enteric coated.
Its enteric coating comprises enteric film coat, Lac enteric coating, bag enteric film coat, CAP enteric coating, resin enteric coating, enteric sugar-coat, enteric semi-film coating.
The preparation method of krestin enteric diaphragm, krestin is composed material with starch and is mixed, wet granulation, tabletting is put label in the high-efficiency coating pot, 3-8 rev/min is blown into 40-50 ℃ of hot blast 15-25 minute in the rotation, spray into coating solution, blowing hot-air parches the sheet sub-surface, blow room temperature wind, wait sheet to be cooled to room temperature and get final product.
The preparation method of krestin enteric coated capsule, krestin mixes with a small amount of adjuvant, is filled in the capsule sealing, put in the high-efficiency coating pot, in the rotation 3-5 rev/min, be blown into 40-50 ℃ of hot blast 20 minutes, spray into coating solution, blowing hot-air, the sheet sub-surface is parched, blow room temperature wind, wait sheet to be cooled to room temperature and get final product.
The preparation method of krestin enteric timed release tablet, this method is with krestin and microcrystalline Cellulose, and starch supplementary material sieves respectively, mixing, make adhesive with PVP ethanol, the system soft material is crossed 20 mesh sieves, 45-55 ℃ of drying, 18 mesh sieve granulate add the magnesium stearate talc tabletting, get label; Eudrigit S100 and ethyl cellulose are dissolved in the ethanol, add plasticizer, mixing filters decontamination; With its filtrate coating in coating pan, rotating speed 40-45 rev/min, the coated tablet weightening finish is 2% of sheet heavy amount.
The preparation method of krestin microporous membrane coated tablet, this method are got krestin and are added adjuvants such as starch, and mixing is granulated with the 8-15% starch slurry, in 50-80 ℃ of drying, add Pulvis Talci slugging; Get cellulose acetate, PEG1500, polysorbate 80 and make coating solution, the sheet heart is put in the coating pan, sparge on the flow patch with 20-40mL/min with nozzle with acetone, the blowing hot-air drying, repeatable operation to thickness 15-80mg/ sheet gets final product.
The preparation method of krestin controlled release micro pill, this method is put into the rotation coating pan as the 20-30 order sucrose granules of carrier, under the 35-45 ℃ of condition, an amount of 17%HPC aqueous solution is added with the spraying of 5-7ml/min speed, then krestin is added 40-45 ℃ of drying, get 16-32 order granule, this granule is put in the rotation coating pan, is to spray into coating material EC and PEG600 solution under 10 rev/mins of conditions at rotating speed, must do granule after the drying.
The preparation method of krestin enteric-coated microcapsule, krestin is dissolved in the 0.5-5% gelatin solution, ethyl cellulose is dissolved in dichloromethane, the gelatin solution that in this solution, slowly adds pastille, 20-25 ℃ mechanical agitation 20-40 minute, make Wr/O Emulsion, then in 0.5% aqueous gelatin solution of making in advance, 20-25 ℃ slowly adds above-mentioned Emulsion, continues to stir 30 minutes, makes (Wr/O)/W
IIThe type multiple emulsion; Continuous stirring under reduced pressure boils off the dichloromethane in the oil phase, and wall membrane substance ethyl cellulose experiment is separated, and then with 35-45 ℃ of warm water cyclic washing, and microcapsule is dispersed in 5% the tween 20 aqueous solution, promptly.
The enteric coated preparation of method preparation of the present invention, adopted the present world the most frequently used, very authoritative enteric coated preparation quality evaluation system carries out quality assessment, and the dissolution determination dissolution medium is with water, 0.1mol/L hydrochloric acid, buffer (pH value 3-6), detection method: change blue laws, 100 rev/mins; The oar method, 50 rev/mins.Measure 45 minutes dissolution.Disintegration: disintegrate means that solid preparation checking the molten diffusing or one-tenth particle of whole disintegrates in the time limit, except that the capsule shells of insoluble coating material or fragmentation, should pass through screen cloth.Release: release means oral drugs from slow releasing preparation, speed that controlled release preparation or enteric coated preparation discharge in standard solution and degree.Be used for controlled release and slow releasing preparation, press the first method inspection of Chinese Pharmacopoeia appendix release.Be used for enteric coated preparation, press the second method inspection of Chinese Pharmacopoeia appendix release.Release checks that used medium is identical with dissolution.Test contrasts with the krestin conventional formulation, and result of the test is shown in table one, table two.
Table one. result of the test
Disintegration time in the name of an article gastric juice (minute)
Krestin capsule (commercially available) 7 (meansigma methods)
Enteric coated formulation of Coriolus Versicolor Polysaccharide＞120
Table two. result of the test
Dissolution in the name of an article gastric juice (%)
15 30 45 60 90 120 180 300
Krestin capsule (commercially available) 45 60 80 100---
Enteric coated formulation of Coriolus Versicolor Polysaccharide 0000008 25
Result of the test shows, the preparation disintegrate hardly under one's belt of the present invention's preparation, and not stripping, this just can eliminate conventional formulation disintegrate under one's belt fully, release Coriolus Versicolor P.E. and the bad implication and the side effect that bring.
The specific embodiment
The present invention's protection is main therapeutic component medicine with krestin, the insoluble or minimal amounts of dissolved of stomach, all dosage forms that the intestinal location discharges.Comprise enteric coatel tablets, enteric coated micropill, enteric diaphragm, enteric coated capsule, timed release tablet, microporous membrane coated tablet, control micropill, microsphere, microcapsule, enteric core matrix, and solid or the liquid preparation made with various enteric-coated microsomes.Its consumption: krestin capsule, 1 1-2 grain, every day 3 times, the heavy 0.5g/ grain of capsule.The krestin electuary, each 1-2g, every day 3 times.Krestin k capsule, every day 3g, 1 time clothes or divide and take for 3 times.Refining by to Coriolus Versicolor P.E., purification improves the krestin content standard, is the committed step of preparation enteric coated preparation.
Conventional oral formulations, the krestin content standard is different.As press manyzoned polypore gantai, krestin content only is 6.66%, krestin capsule, dry product contain krestin must not be lower than 25%, the Polystictus Glycopeptide capsule, and national standard is: press dry product and calculate, contain total sugar with glucose meter, be not less than 35%, contain peptide and must not be less than 20% in bovine serum albumin.Need add a certain amount of adjuvant because of preparing most of enteric coated preparation, if by above standard, the dose of the enteric coated preparation every day for preparing is bigger, causes the inconvenience of clinical use.Therefore, before the preparation enteric coated preparation, must improve the content of polysaccharide in the raw material.This result of study, when krestin content 50% when above, raw material can be used for the preparation of various enteric coated preparation, if the preparation enteric coated capsule, the krestin content of Coriolus Versicolor P.E. is getting final product more than 45%.Therefore, the this patent content limit of additional krestin extract simultaneously requires: adopt through refining, the krestin extract of purification prepares enteric coated preparation, the content of its krestin is pressed dry product weight and is calculated, contain total sugar with glucose meter, must not be lower than 45% (percentage by weight), contain peptide, must not be less than 25% (percentage by weight in bovine serum albumin.
Embodiment 1
The krestin enteric coatel tablets, the preparation of micropill: krestin mixes with adjuvants such as starch, and ethanol, water etc. are fountain solution, wet granulation, tabletting.Can be made into micropill with method.Micropill is meant all kinds of pills of diameter less than 2.5mm.
Label bag one deck contagion gown (zein slurry), it is enteric coated to dry up the back., enteric coated after the micropill drying.Enteric coatel tablets, enteric coated micropill, finished product not disintegrate in simulated gastric fluid, and the increase with pH reduces disintegration time in simulated intestinal fluid.Disintegratable in 100-110 minute when pH 6.6, when pH7.5 10-20 minute can disintegrate.Wherein can further make tablet after the micropill bag enteric film coat, other dosage forms such as capsule also can independently become dosage form.
The bag enteric film coat: enteric adjuvant commonly used has: Lac, cellulose acetate-phthalate (CAP), hydroxypropylmethyl cellulose phthalate (HPMCP), polyacrylic resin etc.
Lac enteric coating: after PEG (60-90%) congruent meltingization of Lac (10-40%) with molecular weight (1000-9000), be sprayed on the sheet wicking surface.Also Lac can be dissolved in dehydrated alcohol and make 10-45% solution, add plasticizer such as Oleum Ricini, stearic acid etc. also can add an amount of sodium cholate (0.3-8%) to be increased in the stability in the simulated gastric fluid and to quicken disintegrate in Lac.This product also can with other coating materials such as PVA, PVP, CAP etc. share, to increase the toughness of coating membrane.Each is variant according to the difference of material for the ratio that coating material share, as PVA at 3-30%, CAP 3-50%, PVP 5-40% etc.HP-55 mixes with Lac at 4: 1, dissolve with ethanol liquid coating, coating thickness 0.03-0.2mm (micropill), 0.1-2.5mm (sheet).Above percentage ratio is weight (g)/volume (ml).
CAP enteric coating: CAP (consumption 3-50%) is dissolved in acetone, can share, add diethyl phthalate (0.5-10%) and a small amount of Polyethylene Glycol (3000-9000) with Lac (consumption 5-25% is dissolved in the ethanol).Each component is used preceding mix homogeneously, can add Pulvis Talci and reduce infiltration, according to the thickness of material properties and coating solution prescription decision coatings, above percentage ratio is weight (g)/volume (ml).
The resin enteric coating: the copolymer by methacrylic acid and methyl methacrylate or ethyl ester is a main material.Common product such as German Rohm Eudraigit L or S company produce home products such as acrylic acid II, III number.Correspond respectively to Eudraigit L and S, can obtain the material of different solubility properties by adjusting the two ratio.(3-15%) places hermetic container with resin, add high concentration (100%-85%) ethanol (percent by volume of consumption is 75-95%), adding Polyethylene Glycol or Oleum Ricini (percent by volume is 1-5%) is plasticizer, adds diethyl phthalate and tween 80 etc.Dissolving, standby after stirring evenly.
Enteric sugar-coat: earlier with sheet pericardium sealing coat and several layers of sub-coat, treat that the corner angle bag does not have, unilateral smooth bright and clean after, stop heating, blowing hot-air is to temperature below 35 ℃, unilateral when dry, spray into enteric coating material solution, it is standard that the thickness of coatings is measured disintegration (through 2 hours constant persons of simulated gastric fluid test) with sampling.After having sprayed drying, continue the bag sub-coat, sugarcoating layer, coloured sugarcoating layers etc. are operated as routine.Enteric coating material solution as previously mentioned.
Enteric semi-film coating: behind sheet pericardium layer 2-3 sub-coat, spray into enteric coating material solution, get final product to meeting the disintegrate requirement.Enteric coating material solution as previously mentioned.
The coating solution prescription: CAP enteric coating liquid (units): CAP 1.8, Lac 2.0, acetone 6, ethanol 8, diethyl phthalate 0.2.Method for making: CAP is dissolved in acetone, in addition Lac is dissolved in ethanol, faces times spent two liquid and share, add diethyl phthalate again, mixing, label is put in the high-efficiency coating pot, and (3-5 rev/min) is blown into 45 ℃ of hot blasts 20 minutes in the rotation, sprays into coating solution, blowing hot-air, the sheet sub-surface is parched, blow room temperature wind, wait sheet to be cooled to room temperature and get final product.The heavily about 15mg/ sheet of coatings.
Embodiment 2
Krestin enteric diaphragm: taxes such as krestin and starch material mixes wet granulation, tabletting.Label weight 0.5 gram, the bag enteric film coat.Coating solution prescription (unit is a percent by volume): polypropylene acid resin II, III number 7,90% ethanol 88, tween 80 1.0, diethyl phthalate 1.5, Oleum Ricini 2.5. method for making: take by weighing polypropylene acid resin II, III number, add 95% ethanol, make resin moistening fully under stirring, add a cover and put 24 hours, make it to dissolve fully, add tween 80, diethyl phthalate again, Oleum Ricini is added a cover standby after stirring evenly.Label is put in the high-efficiency coating pot, and (3-8 rev/min) is blown into 45 ℃ of hot blasts 20 minutes in the rotation, sprays into coating solution, and blowing hot-air parches the sheet sub-surface, blows room temperature wind, waits sheet to be cooled to room temperature and gets final product.The heavily about 20mg/ sheet of coatings.
PVAP 10%, triethyl citrate 1%, and stearic acid 2%, ethanol 87% dissolves the back with above-mentioned method coating, clothing layer thickness 0.2-4mm, above percentage ratio is weight percentage.
Embodiment 3
The preparation of krestin enteric coated capsule:
1, krestin mixes with a small amount of adjuvant, is filled in the enteric coated capsule, and finished product did not change in simulated gastric fluid in 2 hours, and 20-30 minute is disintegrate in simulated intestinal fluid.
2, krestin mixes with a small amount of adjuvant, is filled in conventional No. 1 capsule sealing.Put in the high-efficiency coating pot, (3-5 rev/min) is blown into 45 ℃ of hot blasts 20 minutes in the rotation, sprays into coating solution, and blowing hot-air parches the sheet sub-surface, blows room temperature wind, waits sheet to be cooled to room temperature and gets final product.The kind of enteric coating liquid and the prescription with under the enteric coatel tablets item, coating thickness 1-3mm.
Embodiment 4
The enteric timed release tablet: with krestin and microcrystalline Cellulose, adjuvants such as starch sieve respectively, and mixing is made adhesive with PVP ethanol, and the system soft material is crossed 20 mesh sieves, 50 ℃ of dryings, and 18 mesh sieve granulate add tablettings such as magnesium stearate talc, get label.Eudrigit S100 and ethyl cellulose are dissolved in the ethanol, add plasticizer (Polyethylene Glycol), mixing filters decontamination.With its filtrate coating in coating pan, 42 rev/mins of rotating speeds, the coated tablet weightening finish is 2% of sheet heavy amount.Finished product not release under one's belt enters small intestinal release in about 20 minutes.
Embodiment 5
Krestin microporous membrane coated tablet: get krestin and add adjuvants such as starch, mixing is granulated with 10% starch slurry, in 50-80 ℃ of drying, adds the isobaric pharmacy of Pulvis Talci.Get the 7g cellulose acetate, 2g PEG1500, the 0.5g polysorbate 80,150mL makes coating solution with acetone, and the sheet heart is put in the coating pan, sparge on the flow patch with 20-40mL/min with nozzle, the blowing hot-air drying, repeatable operation to thickness 18mg/ sheet gets final product.
Embodiment 6
Krestin controlled release micro pill: put into the rotation coating pan as the sucrose granules (20-30 order) of carrier, under 40 ℃ of conditions, an amount of 17%HPC aqueous solution is added with the spraying of 5-7ml/min speed, then krestin is added, 40 ℃ of dryings get granule (16-32 order).This granule is put in the rotation coating pan, is to spray into coating material EC and PEG600 (1: 1) solution under 10 rev/mins of conditions at rotating speed, must do granule after the drying.
Controlled release micro pill can further be made capsule, other dosage forms such as tablet.Finished product did not change in simulated gastric fluid in 2 hours, was disintegrate about 20 minutes in simulated intestinal fluid.
Embodiment 7
The preparation of krestin enteric-coated microcapsule: microcapsule system utilizes tiny capsules natural or that synthetic macromolecular material wraps up solid or liquid medicine the diameter 1-500um that forms. and this product adopts the second emulsifying legal system to be equipped with microcapsule.
Method for making: krestin is dissolved in (gelatin concentration 0.5-5%) is dissolved in dichloromethane with ethyl cellulose in the gelatin solution, the gelatin solution that in this solution, slowly adds pastille, about 30 minutes of 20 ℃ of mechanical agitation, make Wr/O Emulsion, then in 0.5% aqueous gelatin solution of making in advance, 20 ℃ slowly add above-mentioned Emulsion, continue to stir 30 minutes, make (Wr/O)/W
IIThe type multiple emulsion.Continuous stirring under reduced pressure boils off the dichloromethane in the oil phase, and the experiment of wall membrane substance ethyl cellulose is separated.And then with 40 ℃ of warm water cyclic washings, microcapsule is dispersed in 5% the tween 20 aqueous solution, promptly.Finished product is not release in 2 hours in gastric juice, release about 20 minutes in the intestinal juice.Microcapsule can further be made solid preparation and liquid preparations such as tablet, capsule.
Claims (10)
1, a kind of enteric coated formulation of Coriolus Versicolor Polysaccharide, it is with from Basidiomycetes, Polyporaceae, manyzoned polypore sporophore and solid culture, and the proteoglycan that extracts in the mycelium of liquid culture is main effective ingredient, its preparation comprises enteric coatel tablets, enteric coated micropill, enteric diaphragm, enteric coated capsule, timed release tablet, microporous membrane coated tablet, control micropill, microsphere, microcapsule, enteric core matrix, and solid or the liquid preparation made with enteric-coated microsome.
2, polysaccharide enteric coated preparation according to claim 1, wherein the proteoglycan that is extracted is for process is refining, the krestin extract of purification, the content of its krestin is pressed dry product weight and is calculated, contain total sugar with glucose meter, be not less than 45%, contain peptide in bovine serum albumin, be no less than 25%.
3, the preparation method of krestin enteric coatel tablets is mixed krestin with starch supplementary material, ethanol, water are fountain solution, wet granulation, and tabletting, label bag one deck contagion gown, it is enteric coated to dry up the back.
4, the preparation method of krestin enteric coated micropill, krestin mixes with starch supplementary material, and ethanol, water are fountain solution, make micropill, micropill bag one deck contagion gown, dry back is enteric coated.
5, the preparation method of krestin enteric diaphragm, krestin is composed material with starch and is mixed, wet granulation, tabletting is put label in the high-efficiency coating pot, 3-8 rev/min is blown into 40-50 ℃ of hot blast 15-25 minute in the rotation, spray into coating solution, blowing hot-air parches the sheet sub-surface, blow room temperature wind, wait sheet to be cooled to room temperature and get final product.
6, the preparation method of krestin enteric coated capsule, krestin mixes with a small amount of adjuvant, is filled in the capsule sealing, put in the high-efficiency coating pot, in the rotation 3-5 rev/min, be blown into 40-50 ℃ of hot blast 20 minutes, spray into coating solution, blowing hot-air, the sheet sub-surface is parched, blow room temperature wind, wait sheet to be cooled to room temperature and get final product.
7, the preparation method of krestin enteric timed release tablet, this method is with krestin and microcrystalline Cellulose, and starch supplementary material sieves respectively, mixing, make adhesive with PVP ethanol, the system soft material is crossed 20 mesh sieves, 45-55 ℃ of drying, 18 mesh sieve granulate add the magnesium stearate talc tabletting, get label; Eudrigit S100 and ethyl cellulose are dissolved in the ethanol, add plasticizer, mixing filters decontamination; With its filtrate coating in coating pan, rotating speed 40-45 rev/min, the coated tablet weightening finish is 2% of sheet heavy amount.
8, the preparation method of krestin microporous membrane coated tablet, this method are got krestin and are added adjuvants such as starch, and mixing is granulated with the 8-15% starch slurry, in 50-80 ℃ of drying, add Pulvis Talci slugging; Get cellulose acetate, PEG1500, polysorbate 80 and make coating solution, the sheet heart is put in the coating pan, sparge on the flow patch with 20-40mL/min with nozzle with acetone, the blowing hot-air drying, repeatable operation to thickness 15-80mg/ sheet gets final product.
9, the preparation method of krestin controlled release micro pill, this method is put into the rotation coating pan as the 20-30 order sucrose granules of carrier, under the 35-45 ℃ of condition, an amount of 17%HPC aqueous solution is added with the spraying of 5-7ml/min speed, then krestin is added 40-45 ℃ of drying, get 16-32 order granule, this granule is put in the rotation coating pan, is to spray into coating material EC and PEG600 solution under 10 rev/mins of conditions at rotating speed, must do granule after the drying.
10, the preparation method of krestin enteric-coated microcapsule, krestin is dissolved in the 0.5-5% gelatin solution, ethyl cellulose is dissolved in dichloromethane, the gelatin solution that in this solution, slowly adds pastille, 20-25 ℃ mechanical agitation 20-40 minute, make Wr/O Emulsion, then in 0.5% aqueous gelatin solution of making in advance, 20-25 ℃ slowly adds above-mentioned Emulsion, continues to stir 30 minutes, makes (Wr/O)/W
IIThe type multiple emulsion; Continuous stirring under reduced pressure boils off the dichloromethane in the oil phase, and wall membrane substance ethyl cellulose experiment is separated, and then with 35-45 ℃ of warm water cyclic washing, and microcapsule is dispersed in 5% the tween 20 aqueous solution, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410065405 CN1631373A (en) | 2004-12-02 | 2004-12-02 | Enteric coated formulation of Coriolus Versicolor Polysaccharide and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410065405 CN1631373A (en) | 2004-12-02 | 2004-12-02 | Enteric coated formulation of Coriolus Versicolor Polysaccharide and its preparation process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1631373A true CN1631373A (en) | 2005-06-29 |
Family
ID=34846486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410065405 Pending CN1631373A (en) | 2004-12-02 | 2004-12-02 | Enteric coated formulation of Coriolus Versicolor Polysaccharide and its preparation process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1631373A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101086007B (en) * | 2007-06-15 | 2012-09-26 | 上海芝草生物技术有限公司 | Manyzoned polypore glycopeptide production method and formulation thereof |
| CN106137977A (en) * | 2015-04-28 | 2016-11-23 | 浙江普利药业有限公司 | Stichopus japonicus polysaccharide enteric coated micropill and preparation method thereof |
| CN107811991A (en) * | 2017-11-27 | 2018-03-20 | 广东省微生物研究所（广东省微生物分析检测中心） | The preparation method of the enteric coated preparations of the FOS containing Morinda officinalis and the preparation being prepared |
-
2004
- 2004-12-02 CN CN 200410065405 patent/CN1631373A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101086007B (en) * | 2007-06-15 | 2012-09-26 | 上海芝草生物技术有限公司 | Manyzoned polypore glycopeptide production method and formulation thereof |
| CN106137977A (en) * | 2015-04-28 | 2016-11-23 | 浙江普利药业有限公司 | Stichopus japonicus polysaccharide enteric coated micropill and preparation method thereof |
| CN106137977B (en) * | 2015-04-28 | 2019-12-13 | 浙江普利药业有限公司 | Sea cucumber polysaccharide enteric-coated pellet and preparation method thereof |
| CN107811991A (en) * | 2017-11-27 | 2018-03-20 | 广东省微生物研究所（广东省微生物分析检测中心） | The preparation method of the enteric coated preparations of the FOS containing Morinda officinalis and the preparation being prepared |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60038097T2 (en) | SOLID ORAL DOSAGE FORM CONTAINING A RESORPTION AMPLIFIER | |
| CN1195499C (en) | Enteric coated pharmaceutical tablet and method of manufacturing | |
| US20040131669A1 (en) | Modified release pharmaceutical composition | |
| CN1972674B (en) | Medicament in a multilayer form | |
| AU2006281415A1 (en) | Pancreatin micropellet cores suitable for enteric coating | |
| AU2007266574A1 (en) | Multiple unit pharmaceutical formulation | |
| CN100367967C (en) | Fasudic hydrochloride oral formulation | |
| CN101502491B (en) | Dirithromycin enteric-coated formulation | |
| CN104688700A (en) | Readily soluble tenofovir disoproxil fumarate tablets and preparation method thereof | |
| CN103356489A (en) | Proton pump inhibitor enteric coated pellet and preparation and preparation method thereof | |
| CN100488515C (en) | Ground erythromycin enteric micropill and its preparation method | |
| CN100441193C (en) | Antipyretic and analgetic aspirin enteric-coated preparation and production thereof | |
| AU2010346995B2 (en) | Pharmaceutical or neutraceutical formulation | |
| CN104997748B (en) | A kind of Nifedipine slow release tablet and its preparation technology for treating hypertension emergency | |
| CN109568284B (en) | Tenofovir alafenamide enteric-coated tablet and preparation method thereof | |
| CN1631373A (en) | Enteric coated formulation of Coriolus Versicolor Polysaccharide and its preparation process | |
| CN101120929A (en) | Gabapentin stomach retention sustained-release composition | |
| CN102753146B (en) | Orally administrable pharmaceutical pellet of epidermal growth factor | |
| Mounica et al. | A review on recent advances in enteric coating and enteric polymers | |
| CN101143136A (en) | Paroxetine slow release micropills preparation | |
| CN115770229A (en) | Clopidogrel sulfate aspirin tablet and preparation method and application thereof | |
| CN101491535B (en) | Method for preparing azithromycin composition with reduced bitter | |
| CN103142659B (en) | Film coating tablet containing staphylococcus neisseria | |
| CN108703956A (en) | A kind of solid composite medicament containing Bosentan | |
| CN1295469A (en) | Hydroxypylcellulose and anionic polymer compositions and their use as pharmaceutical film coatings |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |