CN1631247A - Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof - Google Patents
Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof Download PDFInfo
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- CN1631247A CN1631247A CNA200510002275XA CN200510002275A CN1631247A CN 1631247 A CN1631247 A CN 1631247A CN A200510002275X A CNA200510002275X A CN A200510002275XA CN 200510002275 A CN200510002275 A CN 200510002275A CN 1631247 A CN1631247 A CN 1631247A
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- vitamin
- tablet
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- essence
- acid
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- 238000000034 method Methods 0.000 title description 2
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Abstract
The invention discloses a health food with hypoxia preventing and anti-fatigue function and preparation process, which utilizes acanthopanax root extract, taurine and vitamins as raw material, bulking agent, crumbling agent, flow aid, and lubricating agent as adjuvant, and flavoring agent, bonding agent or dressing material, and right amount of effervescent agent can be charged. The invention also discloses the process for preparing the preparation and the use of the preparation.
Description
Technical field
The present invention relates to a kind of health food and preparation technology thereof of hypoxia preventing and anti-fatigue function.The main active of this health food contains siberian Ginseng P.E, taurine and vitamin.The present invention relates to prepare the method for described health food and the application of this product.
Background technology
Fatigue is a kind of sub-health state that is between disease and the health, usually causes diseases such as insomnia, indigestion, hypertension, very harmful to the mankind.Along with rapid development of economy, dog-eat-dog, rhythm of life is accelerated, and fatigue just influences human beings'health with darker degree and wider scope.That tired crowd often occurs is unable to do what one wishes, lack phenomenons such as life enthusiasm and enjoyment.
The present invention is a main active with wilsonii and taurine, and development removes a kind of functional food of alleviating fatigue, anti-anoxic.
The main chemical compositions of wilsonii has eleutheroside A (Eleutheroside A, be the cupreol glycoside), Eleutheroside B (being ligustrin Syringin), Eleutheroside B 1 (promptly 6,8-escoparone-7-glycoside), eleutheroside (being the galactite glucoside), eleutheroside D and E (being two kinds of not glycosides of the syringaresinol of isomorphism type) etc.In addition, still contain polysaccharide and 1-sesamin (1-Sesamin).
Acanthopanax senticosus is like genseng, have the function of regulating the body disorder and make it to be tending towards normal effect, " adapting to former " sample effect is arranged, can regulate the metabolic function of body, improve the nonspecific resistance of body the destructive stimulus factor (as cold, scorching hot, overweight, overlabor, the irradiation of x line etc.); Can strengthen the function of hypophysis-interrenal system, improve the adaptability and the tolerance of body, lower of the infringement of the multiple virulence factor in inside and outside body.After the senile chronic patient obeys the wilsonii preparation, can strengthen muscle power, make symptom such as weak, tired, poor appetite eliminate or alleviate, and the effect of improving mental activity and raising eyesight, hearing is arranged.Be used for senile debility clinically,, poor appetite weak to body void, insomnia and dreamful sleep, neurosis etc. have certain curative effect.
Pharmacological research shows that siberian Ginseng P.E has following effect:
1. good antifatigue effect is arranged, remarkable than genseng, and can improve hypoxia-bearing capability significantly;
2. can strengthen body nospecific immunity protection capability, mouse reticuloendothelial system phagocytic function is significantly strengthened, normal mouse and mice with tumor spleen weight are increased, macrophage mean value obviously increases in the spleen;
3. formation that can enhancing antibody;
4. improve mouse e rosette formation rate;
5. the leucocyte that rabbit benzene poisoning and mouse are taken caused by cyclophosphamide reduces all prevention effect;
6. the transfer and the spontaneous leukaemia of mouse of transplanting cancer, cancer had certain inhibitory action, its effect is stablized by force than genseng, and can alleviate the toxicity of cancer therapy drug.The extract of Radix Acanthopanacis Senticosi root still has central excitation, the anti-power of regeneration that stress, promote liver, improve the biosynthesis of protein, reduce basic metabolism, promote sexual gland and effect such as bring high blood pressure down.
Experiment shows that the work that wilsonii increases the body nonspecific resistance is the strongest in order to eleutheroside e.This product is taken for a long time and is not seen any bad reaction.
Taurine is a kind of special amino acid, is the requisite a kind of nutrient of human body, and the marvellous effect of balance health is arranged.Except eyes, taurine also has important effect to other organ.For example, through studies confirm that content of taurine is the highest in the human heart.Taurine strengthens cardiac function by protecting cardiac muscle.Measure when too high when calcium ion inflow among the cardiac muscle cell, will cause coronary heart disease.Taurine can be adjusted the amount of calcium ion among the cardiac muscle cell, keeps its balance, realizes cardiac stimulant.The relation of taurine and heart has become one of problem of whole world primary study.In addition, taurine all has protective effect to lung, liver, stomach and intestine etc.
Aspect daily life, the most significant effect of taurine just is to strengthen immunity and antifatigue.Taurine can and generate the avirulence material in conjunction with the hypochlorous acid in the leucocyte, reduces the destruction of hypochlorous acid to leucocyte self, thereby improves body immunity.Simultaneously, taurine can be kept cardiac function, makes blood circulation normalization, thereby eliminates tired product, makes human body produce power effectively.Keep constant taurine in the body, just can eliminate fatigue effectively, this is a key factor of keeping health.
Summary of the invention
The object of the present invention is to provide a kind of prescription and preparation method thereof of health food of hypoxia preventing and anti-fatigue function.The contained main active of the present invention has siberian Ginseng P.E, taurine and vitamin.Vitamin among the present invention comprises the vitamin that all are known, can singlely use, use also capable of being combined; Preferred compositions is used vitamin B1, vitamin B2 and vitamin B6.
Can be used in combination by arbitrary proportion between contained each active component of the present invention; The per unit preparation that consists of of preferred active component contains siberian Ginseng P.E 100mg, taurine 200mg, vitamin B1 0.06mg, vitamin B2 0.06mg and vitamin B6 0.06mg.
Health food of the present invention can be made granule, capsule, also can be pressed into various tablets (comprising tablet forms such as plain edition tablet/dispersing tablet, chewable tablets, buccal tablet, oral disnitegration tablet and effervescent tablet).Except that active component, also have auxiliary materials such as filler, disintegrant, lubricant in the prescription, according to circumstances can also add flavouring, glidant, adhesive, effervescent agent or coating material.
The prescription of health food of the present invention consists of: active component (10-90) %, adhesive (0-5) %, filler (10-80) %, disintegrant (0.1-35) %, flavouring (0-40) %, coating material (0-40) %, effervescent agent (0-30) %, glidant (0-5) %, lubricant (0-3) %.
The selection kind of the various auxiliary materials of health food of the present invention is as follows:
Adhesive includes but are not limited to starch, pregelatinized starch, dextrin, maltodextrin, sucrose, Arabic gum, gelatin, methylcellulose, carboxymethyl cellulose, ethyl cellulose, polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone (PVP), alginic acid and alginate, xanthans, hydroxypropyl cellulose and hydroxypropyl methylcellulose (HPMC), can use use also capable of being combined separately.
Filler include but are not limited to sweet mellow wine (granular or powdery), xylitol, sorbierite, maltose, Chi ?alcohol, microcrystalline cellulose, PROSOLV SMCC, polymerization sugar (EMDEX), coupling sugar, glucose, lactose, sucrose, dextrin and starch etc., can use separately, also can applied in any combination.
Disintegrant includes but are not limited to microcrystalline cellulose, PROSOLV SMCC, PVPP (PVPP), sodium carboxymethyl starch (CMS-Na), low substituted hydroxy-propyl methylcellulose (L-HPC), Ac-Di-Sol (CCNa) and soybean polyoses (EMCOSOY) etc., can use use also capable of being combined separately.
Flavouring includes but are not limited to sweet mellow wine, xylitol, Stevioside, lactose, fructose, sucrose, albumen sugar, maltitol, glycyrrhizin, Sodium Cyclamate, gelatin, Aspartame, flavoring banana essence, flavoring pineapple essence, vanillic aldehyde, fragrant citrus essence, flavoring orange essence, peppermint essence, ginseng essence, strawberry essence, citric acid, citric acid etc., can use use also capable of being combined separately.
Coating material includes but are not limited to commercially available dressing pre-mixing agent, alginate, shitosan, carboxymethyl cellulose salt, cellulose acetate phthalate ester, ethyl cellulose, methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, crylic acid resin (homemade acrylic resin I, II, III, IV, Eudragit series), polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol etc., can use use also capable of being combined separately; Corresponding plasticizer can be added, also pigment and color lake etc. can be added.
Glidant includes but are not limited to superfine silica gel powder, talcum powder, Cab-O-sil erosil, hydration sial acid sodium etc., can use use also capable of being combined separately.
Lubricant includes but are not limited to dolomol, calcium stearate, zinc stearate, single stearic acid glycerine lipoprotein, polyethylene glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyl 40 stearate, single bay sucrose acid ester, sldium lauryl sulfate, magnesium laurylsulfate, Stepanol MG and talcum powder etc., can use use also capable of being combined separately.
Effervescent agent includes but are not limited to the mixture of malic acid, citric acid or fumaric acid and sodium acid carbonate or sodium carbonate.
Another object of the present invention is applied to the aspects such as hypoxia-bearing capability that mammal and people are alleviated fatigue and improved them with each dosage form of health food of the present invention.
Specific embodiment
The following example is in order to describe the present invention better, rather than restriction the present invention.
Embodiment one normal packet garment piece
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. filler microcrystalline cellulose 200.0g;
Starch 300.0g;
3. disintegrating agent carboxymethyl base Starch Sodium 39.82g;
4. magnesium stearate lubricant 10.0g;
5. coating material film coating pre-mix dose 10.0g.
Make 1000 altogether.
Two. the preparation method
1) taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 are crossed 100 mesh sieves respectively, standby;
2) microcrystalline cellulose and starch are crossed 80 mesh sieves respectively, standby;
3) with step 1) and step 2) material mix by recipe quantity, standby;
4) with the material dry granulation of step 3), cross the whole grain of 26 mesh sieves, standby;
5) sodium carboxymethyl starch and the dolomol of adding recipe quantity, mixing;
6) intermediate content detection, determine that sheet is heavy after, send into the tablet press machine compressing tablet, hardness is controlled at 80～100 newton;
7) with plain coating tablets, promptly.
Embodiment two capsules
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. filler microcrystalline cellulose 91.82g;
2 adhesive hydroxypropyl methylcellulose 4.0g;
4. glidant superfine silica gel powder 4.0g;
Make 1000 capsules altogether.
Two. the preparation method
1) taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 are crossed 100 mesh sieves respectively, standby;
2) microcrystalline cellulose and hydroxypropyl methylcellulose are crossed 80 mesh sieves respectively, standby;
3) with step 1) and step 2) material mix by recipe quantity, standby;
4) material with step 3) places high-speed stirring mixer, is that adhesive is granulated with 75% ethanolic solution, crosses the whole grain of 20 mesh sieves, drying;
5) superfine silica gel powder of adding recipe quantity, mixing;
6) encapsulated, promptly.
Embodiment three granules
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. filler microcrystalline cellulose 200.0g;
Sweet mellow wine 434.82g;
Cane sugar powder 400.0g;
3. disintegrant soybean polyoses 150.0g;
4. glidant superfine silica gel powder 15.0g;
Make 1000 pouches altogether.
Two. the preparation method
1) taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 are crossed 100 mesh sieves respectively, standby;
2) microcrystalline cellulose, sweet mellow wine and cane sugar powder are crossed 80 mesh sieves respectively, standby;
3) with step 1) and step 2) material mix by recipe quantity, standby;
4) material with step 3) is the wetting agent wet granulation with 50% ethanolic solution, crosses 35 mesh sieves on extruder, whole grain, and dry back is standby;
5) superfine silica gel powder of adding recipe quantity, mixing;
6) intermediate content detection, pack, promptly.
Embodiment four chewable tablets
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. filler polymerization sugar 440.0g;
Microcrystalline cellulose 80.0g;
3. adhesive hydroxypropyl methylcellulose 3.82g;
4. glidant superfine silica gel powder 8.0g;
5. flavouring Aspartame 5.0g;
Ginseng essence 5.0g;
6. magnesium stearate lubricant 8.0g.
Make 1000 altogether.
Two. the preparation method
1) taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 are crossed 100 mesh sieves respectively, standby;
2) microcrystalline cellulose, Aspartame, ginseng essence and hydroxypropyl methylcellulose are crossed 80 mesh sieves, standby;
3) with step 1) and step 2) material mix by recipe quantity, standby;
4) be that wetting agent is granulated with the material of step 3) with 50% ethanolic solution, cross the whole grain of 26 mesh sieves, standby;
5) polymerization sugar, superfine silica gel powder and the dolomol of adding recipe quantity, mixing;
6) intermediate content detection, determine that sheet is heavy after, send into the tablet press machine compressing tablet, hardness is controlled at 80～100 newton, promptly.
Embodiment five buccal tablets
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. filler sweet mellow wine (granular) 520.0g;
3. adhesive hydroxypropyl methylcellulose 3.82g;
4. glidant superfine silica gel powder 8.0g;
5. flavouring Aspartame 5.0g;
Peppermint essence 5.0g;
6. magnesium stearate lubricant 8.0g.
Make 1000 altogether.
Two. the preparation method
1) with the dissolve with ethanol solution of hydroxypropyl methylcellulose (3 centipoise), standby with 50%;
2) Aspartame is suspended in the above-mentioned solution, standby;
3) taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 are crossed 100 mesh sieves respectively, put in the fluid bed, with step 2) suspension top spray grain, drying;
4) with the material of step 3) and peppermint essence, sweet mellow wine, superfine silica gel powder and the dolomol of recipe quantity, mixing;
5) intermediate content detection, determine that sheet is heavy after, send into the tablet press machine compressing tablet, hardness is controlled at 80～100 newton, promptly.
Embodiment six oral disnitegration tablets
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. coating material Eudragit E100 36.0g;
Eudragit?NE30D?30.0g；
3. filler sweet mellow wine (granular) 410.82g;
4. disintegrant PVPP 48.0g;
Low-substituted hydroxypropyl cellulose 20.0g;
5. flavouring Aspartame 5.0g;
Peppermint essence 5.0g;
6. glidant superfine silica gel powder 8.0g;
7. magnesium stearate lubricant 8.0g.
Make 1000 altogether.
Two. the preparation method
1) with Eudragit E100 and Eudragit NE30D with an amount of 95% dissolve with ethanol solution, standby;
2) Aspartame is suspended in the above-mentioned solution, standby;
3) taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 are crossed 100 mesh sieves respectively, put in the fluid bed, with step 2) suspension at the bottom of the spray dressing, drying;
4) with the material of step 3) and PVPP, low-substituted hydroxypropyl cellulose, peppermint essence, sweet mellow wine, superfine silica gel powder and the dolomol of recipe quantity, mixing;
5) intermediate content detection, determine that sheet is heavy after, send into the tablet press machine compressing tablet, hardness is controlled at 15～35 newton, promptly.
Embodiment seven dispersing tablets
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. coating material hydroxypropyl methylcellulose (3 centipoise) 60.0g;
3. filler sweet mellow wine (granular) 399.82g;
Microcrystalline cellulose 100.0g;
4. disintegrant PVPP 60.0g;
Low-substituted hydroxypropyl cellulose 40.0g;
5. flavouring Stevioside 20.0g;
6. glidant superfine silica gel powder 10.0g;
7. magnesium stearate lubricant 10.0g.
Make 1000 altogether.
Two. the preparation method
1) hydroxypropyl methylcellulose is dissolved with an amount of pure water solution, standby;
2) Stevioside is suspended in the above-mentioned solution, standby;
3) with low-substituted hydroxypropyl cellulose, taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 100 mesh sieves, mixing is put in the fluid bed, with step 2) suspension at the bottom of the spray dressing, drying;
4) with the material of step 3) and microcrystalline cellulose, PVPP, sweet mellow wine, superfine silica gel powder and the dolomol of recipe quantity, mixing;
5) intermediate content detection, determine that sheet is heavy after, send into the tablet press machine compressing tablet, hardness is controlled at 40～100 newton, promptly.
Embodiment eight effervescent tablets
One. prescription
1. raw material siberian Ginseng P.E 100.0g;
Taurine 200.0g;
Vitamin B1 0.06g;
Vitamin B2 0.06g;
Vitamin B6 0.06g;
2. coating material Eudragit E100 36.0g;
3. filler polymerization sugar 203.82g;
Microcrystalline cellulose 100.0g;
5. flavouring Stevioside 20.0g;
6. effervescent agent citric acid 170.0g;
Sodium acid carbonate 150.0g;
6. glidant superfine silica gel powder 10.0g;
7. magnesium stearate lubricant 10.0g.
Make 1000 altogether.
Two. the preparation method
1) with Eudragit E100 with an amount of 95% dissolve with ethanol solution, standby;
2) Stevioside is suspended in the above-mentioned solution, standby;
3) with sodium acid carbonate, taurine, siberian Ginseng P.E and vitamin B1, B2 and B6 100 mesh sieves, mixing is put in the fluid bed, with step 2) suspension at the bottom of the spray dressing, drying;
4) with the material of step 3) and microcrystalline cellulose, citric acid, polymerization sugar, superfine silica gel powder and the dolomol of recipe quantity, mixing;
5) intermediate content detection is determined the heavy back of sheet compressing tablet, and hardness is controlled at 50～100 newton, promptly.
Claims (9)
1. the health food with effects such as hypoxia preventing and anti-fatigue functions is characterized in that contained main active has siberian Ginseng P.E, taurine and vitamin, but is not limited only to siberian Ginseng P.E, taurine and vitamin.
2. the vitamin addressed of claim 1 is characterized in that the vitamin that comprises that all are known can singlely using use also capable of being combined; Preferred compositions is used vitamin B1, vitamin B2 and vitamin B6.
3. claim 1 and 2 described active components is characterized in that can being used in combination by arbitrary proportion between each active component; The per unit preparation that consists of of preferred active component contains siberian Ginseng P.E 100mg, taurine 200mg, vitamin B1 0.06mg, vitamin B2 0.06mg and vitamin B6 0.06mg.
4. claim 1,2 and 3 described health food preparations except that active component, also have auxiliary materials such as filler, disintegrant, lubricant in it is characterized in that writing out a prescription, and according to circumstances can also add flavouring, glidant, adhesive, effervescent agent or coating material.
5. claim 1,2,3 and 4 described health food preparations, what it is characterized in that writing out a prescription consists of active component (10-90) %, adhesive (0-5) %, filler (10-80) %, disintegrant (0.1-35) %, flavouring (0-40) %, coating material (0-40) %, effervescent agent (0-30) %, glidant (0-5) %, lubricant (0-3) %.
6. the various auxiliary materials addressed of claim 4 and 5 is characterized in that selection kind separately is as follows:
Adhesive includes but are not limited to starch, pregelatinized starch, dextrin, maltodextrin, sucrose, Arabic gum, gelatin, methylcellulose, carboxymethyl cellulose, ethyl cellulose, polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone (PVP), alginic acid and alginate, xanthans, hydroxypropyl cellulose and hydroxypropyl methylcellulose (HPMC), can use use also capable of being combined separately.
Filler includes but are not limited to sweet mellow wine (granular or powdery), xylitol, sorbierite, maltose, erythrite, microcrystalline cellulose, PROSOLV
SMCC, polymerization sugar (EMDEX
), coupling sugar, glucose, lactose, sucrose, dextrin and starch etc., can use separately, also can applied in any combination.Disintegrant includes but are not limited to microcrystalline cellulose, PROSOLV
SMCC, PVPP (PVPP), sodium carboxymethyl starch (CMS-Na), low substituted hydroxy-propyl methylcellulose (L-HPC), Ac-Di-Sol (CCNa) and soybean polyoses (EMCOSOY
) etc., can use use also capable of being combined separately.
Flavouring includes but are not limited to sweet mellow wine, xylitol, Stevioside, lactose, fructose, sucrose, albumen sugar, maltitol, glycyrrhizin, Sodium Cyclamate, gelatin, Aspartame, flavoring banana essence, flavoring pineapple essence, vanillic aldehyde, fragrant citrus essence, flavoring orange essence, peppermint essence, ginseng essence, strawberry essence, citric acid, citric acid etc., can use use also capable of being combined separately.
Coating material includes but are not limited to commercially available dressing pre-mixing agent, alginate, shitosan, carboxymethyl cellulose salt, cellulose acetate phthalate ester, ethyl cellulose, methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, crylic acid resin (homemade acrylic resin I, II, III, IV, Eudragit
Series), polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol etc., can use use also capable of being combined separately; Corresponding plasticizer can be added, also pigment and color lake etc. can be added.
Glidant includes but are not limited to superfine silica gel powder, talcum powder, Cab-O-sil
, Aerosil
, hydrated sodium aluminosilicate etc., can use use also capable of being combined separately.
Lubricant includes but are not limited to dolomol, calcium stearate, zinc stearate, single stearic acid glycerine lipoprotein, polyethylene glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyl 40 stearate, single bay sucrose acid ester, sldium lauryl sulfate, magnesium laurylsulfate, Stepanol MG and talcum powder etc., can use use also capable of being combined separately.
Effervescent agent includes but are not limited to the mixture of malic acid, citric acid or fumaric acid and sodium acid carbonate or sodium carbonate.
7. the preparation of the described health food of claim 1 to 6 is characterized in that being prepared into dosage forms such as tablet, capsule and granule.
8. the tablet form addressed of claim 7 is characterized in that not only comprising the plain edition tablet, also comprises tablet forms such as dispersing tablet, chewable tablets, buccal tablet, oral disnitegration tablet and effervescent tablet.
9. described any one the dosage form of claim 1 to 8 is in the application that is used for the tired of releasing mammal and people and improves aspects such as hypoxia-bearing capability.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510002275XA CN100438778C (en) | 2005-01-20 | 2005-01-20 | Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200510002275XA CN100438778C (en) | 2005-01-20 | 2005-01-20 | Health food with hypoxia preventing and anti-fatigue function and preparation technique thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1631247A true CN1631247A (en) | 2005-06-29 |
| CN100438778C CN100438778C (en) | 2008-12-03 |
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ID=34852947
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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| Country | Link |
|---|---|
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Address after: 100083 Haidian District, Xueyuan Road, No. 30, A building, room No. 15, room, room 15 Patentee after: COSCI MED-TECH Co.,Ltd. Address before: 100080, Haidian District satellite building, No. 63, Zhichun Road, Beijing, room 1410, Beijing Patentee before: COSCI MED-TECH Co.,Ltd. |
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