CN1628641A - Enteric coated type thin membrane coated premixed agent and preparation method thereof - Google Patents
Enteric coated type thin membrane coated premixed agent and preparation method thereof Download PDFInfo
- Publication number
- CN1628641A CN1628641A CN 200410040651 CN200410040651A CN1628641A CN 1628641 A CN1628641 A CN 1628641A CN 200410040651 CN200410040651 CN 200410040651 CN 200410040651 A CN200410040651 A CN 200410040651A CN 1628641 A CN1628641 A CN 1628641A
- Authority
- CN
- China
- Prior art keywords
- enteric solubility
- film coating
- coating pre
- polyacrylic resin
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Disclosed is an enteric coated type thin membrane coated premixed agent and preparation method, which comprises intestine dissoluble cellulose derivative, intestine dissoluble acrylic resin derivative, polyethylene glycol 6000. The intestine soluble type thin film coated premix has advantages of low cost, simple process for manufacturing, thus fitting for mass production.
Description
Technical field
The present invention relates to a kind of film coating pre-mix dose, and relate to the preparation method of this film coating pre-mix dose.
Background technology
Film coating is to spray the more stable high molecular polymer dress material of one deck on the solid pharmaceutical preparation surface equably by the method for spraying, forms the plastic films layer of number micron thickness.
The enteric solubility film coating is applicable to and does not dissolve in gastric juice and need dissolved drug coating in intestinal juice, its material needs not dissolve or seldom dissolving when Digestive systems such as chance gastric acid, effectively avoid position releases such as oral cavity, esophagus, stomach, but do not influence dissolving and the dissolution time of medicine in intestinal juice.The film-coated material of enteric solubility commonly used has enteric solubility acrylic resin analog derivative, enteric solubility cellulose derivative and enteric solubility polythene derivative etc.
Existing various enteric solubility film coating pre-mix dose, mostly since wherein polymer select for use or to form proportioning unreasonable, after being mixed with the coating serosity, the viscosity that has is too low, cause the clothing film of solid pharmaceutical preparation coating finished product and the poor adhesion of drug core, phenomenons such as finished surface wearing and tearing, film edge ftractures or peel off occur; The viscosity that has is too big, in the coating process, easily forms bigger droplet, and difficulty is evenly distributed on medical surfaces, assembles more and the generation adhesion at medical surfaces, and the density of coating membrane is also poor simultaneously, produces a lot of bubbles; When the viscosity of coating serosity is excessive, also can cause the coatings rough surface of last film coating finished product and elephant skin etc.; When there is the drug core of indentation or sign on the coating surface, if the composition of coating pre-mixing agent is unreasonable, cause the mechanical parameter of clothing film to owe reasonable, too high as coefficient of elasticity, film-strength is relatively poor, adhesiveness is bad etc., in clothing film dry run, produce higher pull-back forces, with the pull-up from indentation of clothing film surface, the thin film retraction, thereby the generation arch formation makes the indentation disappearance of medical surfaces or identifies unclear.
Summary of the invention
Purpose of the present invention just provides a kind of enteric solubility film coating pre-mix dose, and this enteric solubility film coating pre-mix dose modest viscosity is in order to the finished product appearance of coating gained; And with low cost, be suitable for large-scale production.
Another object of the present invention provides a kind of preparation method of enteric solubility film coating pre-mix dose.
The technical solution adopted for the present invention to solve the technical problems is: a kind of enteric solubility film coating pre-mix dose is provided, and its component is: enteric solubility cellulose derivative, enteric solubility acrylic resin analog derivative, polyvidone and polyethylene glycol 6000.These components constitute requisite film former in the pre-mixing agent.Also double as filler and plasticizer of polyethylene glycol 6000 wherein.
The enteric solubility cellulose derivative of above-mentioned pre-mixing agent is a hydroxypropylmethyl cellulose phthalate etc., and enteric solubility acrylic resin analog derivative is polyacrylic resin II number and III number etc., and polyvidone is a 30 POVIDONE K 30 BP/USP-30 etc.
The weight proportion of each component of above-mentioned pre-mixing agent is: hydroxypropylmethyl cellulose phthalate 55-70 part, preferred 60-65 part; Polyacrylic resin II 5-15 part, preferred 5-10 part; Polyacrylic resin III 5-15 part, preferred 5-10 part; 30 POVIDONE K 30 BP/USP-30 is 8-15 part, preferred 8-12 part; Polyethylene glycol 6000 is 2-10 part, preferred 3-7 part.
The preparation method of above-mentioned pre-mixing agent is: each component of described proportioning was mixed in double-cone mixer 10 minutes to 1 hour, get final product.
According to different concrete needs, it is 0.1-25 part as coloring agent and its weight content that above-mentioned enteric solubility film coating pre-mix dose can also contain versicolor color ingot, preferred 8-15 part.
The preparation method of above-mentioned enteric solubility film coating pre-mix dose, its technical process is: with color ingot, the polyacrylic acid resin of described proportioning II number and III number, put into the ball milling mixer together, mix 1 hour after 3 hours, change in the double-cone mixer, the hydroxypropyl emthylcellulose, 30 POVIDONE K 30 BP/USP-30 and the polyethylene glycol 6000 that add described proportioning, remix 10 minutes to 1 hour, promptly.
Above-mentioned enteric solubility film coating pre-mix dose can also contain titanium dioxide and make white color agents double as opacifier, and its weight content is 0.1-25 part, preferred 8-15 part.
Above-mentioned titanium dioxide can not enter the ball mill hammering in the preparation process of enteric solubility film coating pre-mix dose mixes, and directly mixes in double-cone mixer 10 minutes to 1 hour with other various compositions, gets final product.
Compared with prior art, the invention has the beneficial effects as follows:
(1) though adopted raw material polyvidone (PVP) K-30 that is commonly considered as stomach dissolution type among the present invention, but simultaneously because the reasonable utilization of other compositions such as hydroxypropylmethyl cellulose phthalate and polyacrylic acid resin II number, III number, make the present invention not only can reach the coating process and be difficult for effects such as adhesion and good film-forming property, coating finished product appearance, glossiness be good, and can satisfy and in intestinal juice, be dissolved in few dissolved requirement in the gastric juice.
(2) raw material of the present invention is easy to get, and need not import, and the source is abundant, and is with low cost.
(3) its preparation method simple controllable is with short production cycle, is easy to realize the GMP standardized administration, is suitable for large-scale production.
(4) its composition and proportioning thereof are scientific and reasonable, and the mechanical parameter of gained coating membrane is reasonable, and coated drugs arch formation can not take place, and are particularly suitable for the drug coating that there are indentation or sign in the surface.
(5) this enteric solubility film coating pre-mix dose that makes according to described preparation method, its finished product powder exquisiteness, various compositions are rabbeted mutually, mix homogeneously, after being mixed with the coating serosity, modest viscosity, and good film-forming property, with the coating finished product of its coated solid medicament preparation gained, its coatings combines with drug core firmly, and parcel is tight, the thickness homogeneous, uniform coloring, coating manufactured goods surface abrasion can not appear in smooth and beautiful appearance, the film edge cracking, peel off or phenomenon such as adhesion, the good compactness of while coating membrane, can not produce bubble, can not cause the coating finished surface coarse with elephant skin etc. yet, can satisfy the film-coated multiple needs of solid pharmaceutical preparation preferably.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
The composition and the preparation thereof of embodiment one enteric solubility colorless and transparent film coating pre-mixing agent 1
Form:
Hydroxypropylmethyl cellulose phthalate: 70Kg; Polyacrylic resin II number: 5Kg; Polyacrylic resin III number: 5Kg; 30 POVIDONE K 30 BP/USP-30:8Kg; Polyethylene glycol 6000: 3Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixed 1 hour, promptly obtained hydroxypropylmethyl cellulose phthalate and be 70 parts, polyacrylic resin II and number be 5 parts, polyacrylic resin III and number be 5 parts, 30 POVIDONE K 30 BP/USP-30 and be 8 parts and polyethylene glycol 6000 and be 3 parts enteric solubility colorless and transparent film coating pre-mixing agent.
The composition and the preparation thereof of embodiment two enteric solubility colorless and transparent film coating pre-mixing agents 2
Form:
Hydroxypropylmethyl cellulose phthalate: 55Kg; Polyacrylic resin II number: 15Kg; Polyacrylic resin III number: 10Kg; 30 POVIDONE K 30 BP/USP-30:15Kg; Polyethylene glycol 6000: 7Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixed 10 minutes, promptly obtained hydroxypropylmethyl cellulose phthalate and be 55 parts, polyacrylic resin II and number be 15 parts, polyacrylic resin III and number be 10 parts, 30 POVIDONE K 30 BP/USP-30 and be 15 parts and polyethylene glycol 6000 and be 7 parts enteric solubility colorless and transparent film coating pre-mixing agent.
The composition and the preparation thereof of embodiment three enteric solubility colorless and transparent film coating pre-mixing agents 3
Form:
Hydroxypropylmethyl cellulose phthalate: 60Kg; Polyacrylic resin II number: 10Kg; Polyacrylic resin III number: 15Kg; 30 POVIDONE K 30 BP/USP-30:12Kg; Polyethylene glycol 6000: 10Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixed 20 minutes, promptly obtained hydroxypropylmethyl cellulose phthalate and be 60 parts, polyacrylic resin II and number be 10 parts, polyacrylic resin III and number be 15 parts, 30 POVIDONE K 30 BP/USP-30 and be 12 parts and polyethylene glycol 6000 and be 10 parts enteric solubility colorless and transparent film coating pre-mixing agent.
The composition and the preparation thereof of embodiment four enteric solubility colorless and transparent film coating pre-mixing agents 4
Form:
Hydroxypropylmethyl cellulose phthalate: 65Kg; Polyacrylic resin II number: 10Kg; Polyacrylic resin III number: 15Kg; 30 POVIDONE K 30 BP/USP-30:12Kg; Polyethylene glycol 6000: 2Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixes half an hour, promptly obtains hydroxypropylmethyl cellulose phthalate and be 65 parts, polyacrylic resin II and number be 10 parts, polyacrylic resin III and number be 15 parts, 30 POVIDONE K 30 BP/USP-30 and be 12 parts and polyethylene glycol 6000 and be 2 parts enteric solubility colorless and transparent film coating pre-mixing agent.
The composition and the preparation thereof of embodiment five enteric solubility fruit green film coating pre-mix doses
Form:
Hydroxypropylmethyl cellulose phthalate: 70Kg; Polyacrylic resin II number: 5Kg; Polyacrylic resin III number: 10Kg; 30 POVIDONE K 30 BP/USP-30:8Kg; Polyethylene glycol 6000: 2Kg; Fruit green ingot: 15Kg.
Preparation method:
Get the fruit green ingot of above-mentioned weight, polyacrylic resin II number and III number, put into the ball milling mixer together, start mixed after 1 hour, change in the double-cone mixer, the hydroxypropylmethyl cellulose phthalate that adds above-mentioned weight, 30 POVIDONE K 30 BP/USP-30 and polyethylene glycol 6000, drive double-cone mixer again and mixed 20 minutes, promptly obtain weight proportion and be: hydroxypropylmethyl cellulose phthalate is 70 parts, polyacrylic resin II number is 5 parts, polyacrylic resin III number is 10 parts, 30 POVIDONE K 30 BP/USP-30 is 8 parts, polyethylene glycol 6000 is 2 parts, the fruit green ingot is 15 parts of enteric sections fruit green film coating pre-mix doses.
The composition and the preparation thereof of embodiment six enteric solubility blue membrane coating pre-mixing agents
Form:
Hydroxypropylmethyl cellulose phthalate: 55Kg; Polyacrylic resin II number: 15Kg; Polyacrylic resin III number: 15Kg; 30 POVIDONE K 30 BP/USP-30:12Kg; Polyethylene glycol 6000: 10Kg; Indigo ingot: 0.1Kg.
Preparation method:
Get the indigo ingot of above-mentioned weight, polyacrylic resin II number and III number, put into the ball milling mixer together, start mixed after 3 hours, change in the double-cone mixer, the hydroxypropylmethyl cellulose phthalate that adds above-mentioned weight, 30 POVIDONE K 30 BP/USP-30 and polyethylene glycol 6000, drive double-cone mixer again and mixed 10 minutes, promptly obtaining hydroxypropylmethyl cellulose phthalate is 55 parts, polyacrylic resin II number is 15 parts, polyacrylic resin III number is 15 parts, 30 POVIDONE K 30 BP/USP-30 is 12 parts, polyethylene glycol 6000 is that 10 parts and indigo ingot are 0.1 part enteric solubility blue membrane coating pre-mixing agent.
The composition and the preparation thereof of the red film coating pre-mix dose of embodiment seven enteric solubility rust
Form:
Hydroxypropylmethyl cellulose phthalate: 65Kg; Polyacrylic resin II number: 10Kg; Polyacrylic resin III number: 5Kg; 30 POVIDONE K 30 BP/USP-30:15Kg; Polyethylene glycol 6000: 7Kg; Red ingot: the 8Kg of rust.
Preparation method:
Get the fruit green ingot of above-mentioned weight, polyacrylic resin II number and III number, put into the ball milling mixer together, start mixed after 90 minutes, change in the double-cone mixer, the hydroxypropylmethyl cellulose phthalate that adds above-mentioned weight, 30 POVIDONE K 30 BP/USP-30 and polyethylene glycol 6000, drive double-cone mixer again and mixed 1 hour, promptly obtaining hydroxypropyl emthylcellulose content phthalic acid ester is 65 parts, polyacrylic resin II number is 10 parts, polyacrylic resin III number is 5 parts, 30 POVIDONE K 30 BP/USP-30 is 15 parts, polyethylene glycol 6000 is 7 parts of red film coating pre-mix doses of the enteric solubility rust with 8 parts on fruit green ingot.
The composition and the preparation thereof of embodiment eight enteric solubility iron oxide yellow color film coating pre-mix doses
Form:
Hydroxypropylmethyl cellulose phthalate: 60Kg; Polyacrylic resin II number: 8Kg; Polyacrylic resin III number: 8Kg; 30 POVIDONE K 30 BP/USP-30:10Kg; Polyethylene glycol 6000: 3Kg; Yellow ingot: 25Kg.
Preparation method:
Get the fruit green ingot of above-mentioned weight, polyacrylic resin II number and III number, put into the ball milling mixer together, start mixed after 90 minutes, change in the double-cone mixer, the hydroxypropylmethyl cellulose phthalate that adds above-mentioned weight, 30 POVIDONE K 30 BP/USP-30 and polyethylene glycol 6000, drive double-cone mixer again and mixed 1 hour, promptly obtaining hydroxypropyl emthylcellulose content phthalic acid ester is 60 parts, polyacrylic resin II number is 8 parts, polyacrylic resin III number is 8 parts, 30 POVIDONE K 30 BP/USP-30 is 10 parts, polyethylene glycol 6000 is that 3 parts and yellow ingot are 25 parts the red film coating pre-mix dose of enteric solubility rust.
The composition and the preparation thereof of embodiment nine enteric solubility white film coating pre-mixing agents 1
Form:
Hydroxypropylmethyl cellulose phthalate: 65Kg; Polyacrylic resin II number: 8Kg; Polyacrylic resin III number: 8Kg; 30 POVIDONE K 30 BP/USP-30:10Kg; Polyethylene glycol 6000: 6Kg; Titanium dioxide: 10Kg.
Preparation method:
Get the titanium dioxide of above-mentioned weight, polyacrylic resin II number and III number, put into the ball milling mixer together, start mixed after 2 hours, change in the double-cone mixer, the hydroxypropylmethyl cellulose phthalate that adds above-mentioned weight, 30 POVIDONE K 30 BP/USP-30 and polyethylene glycol 6000, drive double-cone mixer again and mixed 40 minutes, promptly obtaining hydroxypropylmethyl cellulose phthalate is 65 parts, polyacrylic resin II number is 8 parts, polyacrylic resin III number is 8 parts, 30 POVIDONE K 30 BP/USP-30 is 10 parts, polyethylene glycol 6000 is that 6 parts and titanium dioxide are 10 parts enteric solubility white film coating pre-mixing agent.
The composition and the preparation thereof of embodiment ten enteric solubility white film coating pre-mixing agents 2
Form:
Hydroxypropylmethyl cellulose phthalate: 60Kg; Polyacrylic resin II number: 10Kg; Polyacrylic resin III number: 5Kg; 30 POVIDONE K 30 BP/USP-30:12Kg; Polyethylene glycol 6000: 3Kg; Titanium dioxide: 15Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixed 30 minutes, promptly obtained hydroxypropylmethyl cellulose phthalate and be 60 parts, polyacrylic resin II and number be 10 parts, polyacrylic resin III and number be 5 parts, 30 POVIDONE K 30 BP/USP-30 and be 12 parts, polyethylene glycol 6000 and be 3 parts and titanium dioxide and be 15 parts enteric solubility white film coating pre-mixing agent.
The composition and the preparation thereof of embodiment 11 enteric solubility white film coating pre-mixing agents 3
Form:
Hydroxypropylmethyl cellulose phthalate: 55Kg; Polyacrylic resin II number: 15Kg; Polyacrylic resin III number: 10Kg; 30 POVIDONE K 30 BP/USP-30:15Kg; Polyethylene glycol 6000: 10Kg; Titanium dioxide: 25Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixed 45 minutes, promptly obtained hydroxypropylmethyl cellulose phthalate and be 55 parts, polyacrylic resin II and number be 15 parts, polyacrylic resin III and number be 10 parts, 30 POVIDONE K 30 BP/USP-30 and be 15 parts, polyethylene glycol 6000 and be the enteric solubility white film coating pre-mixing agent of 25 parts of 10 parts and titanium dioxide.
The composition and the preparation thereof of embodiment 12 enteric solubility white film coating pre-mixing agents 4
Form:
Hydroxypropylmethyl cellulose phthalate: 70Kg; Polyacrylic resin II number: 5Kg; Polyacrylic resin III number: 15Kg; 30 POVIDONE K 30 BP/USP-30:8Kg; Polyethylene glycol 6000: 7Kg; Titanium dioxide: 0.1Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixed 60 minutes, promptly obtained hydroxypropylmethyl cellulose phthalate and be 70 parts, polyacrylic resin II and number be 5 parts, polyacrylic resin III and number be 15 parts, 30 POVIDONE K 30 BP/USP-30 and be 8 parts, polyethylene glycol 6000 and be 7 parts and titanium dioxide and be 0.1 part enteric solubility white film coating pre-mixing agent.
The composition and the preparation thereof of embodiment 13 enteric solubility white film coating pre-mixing agents 5
Form:
Hydroxypropylmethyl cellulose phthalate: 63Kg; Polyacrylic resin II number: 9Kg; Polyacrylic resin III number: 7Kg; 30 POVIDONE K 30 BP/USP-30:13Kg; Polyethylene glycol 6000: 2Kg; Titanium dioxide: 8Kg.
Preparation method:
Get the various compositions of above-mentioned weight, join in the double-cone mixer, start mixed 20 minutes, promptly obtained hydroxypropylmethyl cellulose phthalate and be 63 parts, polyacrylic resin II and number be 9 parts, polyacrylic resin III and number be 7 parts, 30 POVIDONE K 30 BP/USP-30 and be 13 parts, polyethylene glycol 6000 and be 2 parts and titanium dioxide and be 8 parts enteric solubility white film coating pre-mixing agent.
Claims (10)
1, a kind of enteric solubility film coating pre-mix dose is characterized in that, its component is: enteric solubility cellulose derivative, enteric solubility acrylic resin analog derivative, polyvidone and polyethylene glycol 6000.
2, enteric solubility film coating pre-mix dose according to claim 1, it is characterized in that: described enteric solubility cellulose derivative is a hydroxypropylmethyl cellulose phthalate, enteric solubility acrylic resin analog derivative is polyacrylic resin II number and III number, and polyvidone is a 30 POVIDONE K 30 BP/USP-30.
3, enteric solubility film coating pre-mix dose according to claim 2, it is characterized in that: the weight proportion of described component is: hydroxypropylmethyl cellulose phthalate is 55-70 part, polyacrylic resin II number is 5-15 part, polyacrylic resin III number is 5-15 part, 30 POVIDONE K 30 BP/USP-30 is 8-15 part, and polyethylene glycol 6000 is 2-10 part.
4, enteric solubility film coating pre-mix dose according to claim 3, it is characterized in that: the weight proportion of described each component is: hydroxypropylmethyl cellulose phthalate be 60-65 part, polyacrylic resin II number for 5-10 part, polyacrylic resin III number be 3-7 part for 5-10 part, 30 POVIDONE K 30 BP/USP-30 for 8-12 part, polyethylene glycol 6000.
5, according to claim 3 or 4 described enteric solubility film coating pre-mix doses, it is characterized in that: it also contains versicolor color ingot 0.1-25 part.
6, enteric solubility film coating pre-mix dose according to claim 5 is characterized in that: the color ingot that it contains is 8-15 part.
7, according to claim 3 or 4 described enteric solubility film coating pre-mix doses, it is characterized in that: it also contains the titanium dioxide of 0.1-25 part.
8, enteric solubility film coating pre-mix dose according to claim 7 is characterized in that: the titanium dioxide that it contains is 8-15 part.
9, the preparation method of a kind of claim 1,2,3 or 4 described enteric solubility film coating pre-mix doses was mixed each component of described proportioning 10 minutes to 1 hour in double-cone mixer, get final product.
10, a kind of right is wanted the preparation method of 5 described enteric solubility film coating pre-mix doses, with color ingot, the polyacrylic acid resin of described proportioning II number and III number, put into the ball milling mixer together, mix after 1 to 3 hours, change in the double-cone mixer, the hydroxypropyl emthylcellulose, 30 POVIDONE K 30 BP/USP-30 and the polyethylene glycol 6000 that add described proportioning, remix 10 minutes to 1 hour, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410040651 CN1628641A (en) | 2004-09-09 | 2004-09-09 | Enteric coated type thin membrane coated premixed agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410040651 CN1628641A (en) | 2004-09-09 | 2004-09-09 | Enteric coated type thin membrane coated premixed agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1628641A true CN1628641A (en) | 2005-06-22 |
Family
ID=34845848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410040651 Pending CN1628641A (en) | 2004-09-09 | 2004-09-09 | Enteric coated type thin membrane coated premixed agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1628641A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512401A (en) * | 2012-01-16 | 2012-06-27 | 北京英茂药业有限公司 | Water-soluble film coated premix agent |
| CN106075413A (en) * | 2016-06-22 | 2016-11-09 | 扬州洋制药有限公司 | A kind of coating method being applicable to compound azintamide enteric coatel tablets |
| CN106138003A (en) * | 2016-07-11 | 2016-11-23 | 成都中牧生物药业有限公司 | A kind of stable type film coating pre-mix dose and preparation method |
| CN107715113A (en) * | 2017-11-30 | 2018-02-23 | 江苏昕宇药业有限公司 | A kind of enteric solubility film-coating premixing auxiliary material |
| CN109364096A (en) * | 2018-12-25 | 2019-02-22 | 浙江华康药业股份有限公司 | A kind of xylitol enteric coatel tablets and its preparation method and application |
-
2004
- 2004-09-09 CN CN 200410040651 patent/CN1628641A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512401A (en) * | 2012-01-16 | 2012-06-27 | 北京英茂药业有限公司 | Water-soluble film coated premix agent |
| CN102512401B (en) * | 2012-01-16 | 2014-04-30 | 北京英茂药业有限公司 | Water-soluble film coated premix agent |
| CN106075413A (en) * | 2016-06-22 | 2016-11-09 | 扬州洋制药有限公司 | A kind of coating method being applicable to compound azintamide enteric coatel tablets |
| CN106075413B (en) * | 2016-06-22 | 2019-12-31 | 扬州一洋制药有限公司 | Coating method suitable for compound azintamide enteric-coated tablets |
| CN106138003A (en) * | 2016-07-11 | 2016-11-23 | 成都中牧生物药业有限公司 | A kind of stable type film coating pre-mix dose and preparation method |
| CN107715113A (en) * | 2017-11-30 | 2018-02-23 | 江苏昕宇药业有限公司 | A kind of enteric solubility film-coating premixing auxiliary material |
| CN109364096A (en) * | 2018-12-25 | 2019-02-22 | 浙江华康药业股份有限公司 | A kind of xylitol enteric coatel tablets and its preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1206267C (en) | Film coatings and film coating compositions based on polyvinyl alcohol | |
| CN1247190C (en) | Immediate release tablet cores of insoluble drugs having sustained release coating | |
| CN1174745C (en) | Use of coating as taste masking agent for oral preparation | |
| CN1090017C (en) | Controlled release formulation for water soluble drugs in which passageway is formed in situ | |
| CN1178650C (en) | Multiple unit controlled non-independent release pharmaceutical preparations and method for preparing same | |
| CN101380475B (en) | Preparation method of film coating pre-mixing agent and uses thereof | |
| CN1822819A (en) | Oral controlled release forms useful for reducing or preventing nicotine cravings | |
| CN101057849A (en) | Slow-releasing preparation containing metformin hydrochloride and glipizide and its preparation method | |
| CN1480496A (en) | Polyacrylic acid film forming compsn. | |
| CN1388189A (en) | Dip-coating composition containing cellulose ether | |
| CN1384737A (en) | Edible MCC/PGA coating composition | |
| CN1628641A (en) | Enteric coated type thin membrane coated premixed agent and preparation method thereof | |
| CN1839846A (en) | Levofloxacin slow release micropill, its preparation method and uses | |
| JP5524624B2 (en) | Aqueous film coating solution, film coated granule, and tablet using the same | |
| CN1388190A (en) | Dis-coating composition containing starch or starch gum | |
| CN1628856A (en) | Film coated premix dissoluble in stomach and its preparation method | |
| CN101080217A (en) | Enteric film coating composition containing enteric polymer micronized with detackifier | |
| CN101584864A (en) | Method for producing water soluble moistureproof film coating premixing agent | |
| CN1301151A (en) | Regulated release preparations | |
| CN104940027A (en) | Low-shrinkage dental restoration resin and preparation method thereof | |
| CN1275651C (en) | Medical coating powder containing nano material | |
| CN1429545A (en) | Dimethyl silicone oil used as weighting reinforcing agent | |
| CN107213131A (en) | Packaging technique for treating angiocardiopathy solid pharmaceutical preparation | |
| CN1216596C (en) | Acrylic enteric coating compsns. | |
| CN1265785C (en) | Chrono-slow-releasing prepn. hydrochloride verapamil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |