CN1621087A - Fresh product of cordyceps militaris and its preparation method - Google Patents
Fresh product of cordyceps militaris and its preparation method Download PDFInfo
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- CN1621087A CN1621087A CN 200310116654 CN200310116654A CN1621087A CN 1621087 A CN1621087 A CN 1621087A CN 200310116654 CN200310116654 CN 200310116654 CN 200310116654 A CN200310116654 A CN 200310116654A CN 1621087 A CN1621087 A CN 1621087A
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Abstract
The present invention discloses fresh aweto preparations and their preparation process. Fresh aweto without being stoved and freeze dried is prepared into fresh aweto extractum powder through direct shearing, pulping, solid-liquid separation, decompression distillation, alcohol recovering and distillation to eliminate water. The fresh aweto extractum powder is further capsulized to prepare fresh aweto capsule, packed in aluminum-plastic bag to form fresh aweto granule, or dissolved in pure water to prepare fresh aweto beverage.
Description
The present invention relates to a kind of Cordyceps militaris (L.) Link. preparation, particularly bright product Cordyceps militaris (L.) Link. preparation and preparation method thereof.
Cordyceps contains ucleosides: adenosine, cordycepin, adenine, thymus pyrimidine etc., amino acids: alanine, lysine, isoleucine taurine etc.; steroid village alcohols: cholesterol, Hu square-bottomed bamboo basket are foretold glycoside, ergosterol etc.; organic acid: fatty acid, oleic acid, linoleic acid, linolenic acid, palmitic acid etc., vitamins: vitamin B12, vitamin A, vitamin C etc., also have cyclic peptide, inorganic elements or the like.The chemical constituent that people such as He Ling adopt gas phase-mass spectrometry method to study Cordyceps militaris (L.) Link. and Cordyceps finds that main component is basic identical, for the succedaneum of Cordyceps militaris (L.) Link. as Cordyceps provides according to " Chinese medicine magazine " 1993; 28 (5); 279.People such as Tang Rongjiang adopt Qinghai Cordyceps to show to artificial culture Cordyceps fungus pharmacological experiment: the delayed hypersensitivity of calmness, antiinflammatory, hormone-like effect, reduction serum cholesterol, raising blood glucose, the function of expanding isolated tracheal, the stripped ileum of excitement, raising human body mononuclear phagocyte system, adjusting humoral immunization, the lymphocytic conversion of assurance T, inhibition mice is similar, provides foundation from pharmacological angle for artificial culture Cordyceps fungus substitutes natural cordyceps." Chinese herbal medicine " 1985; 16 (11); 9 " Chinese herbal medicine " 1986; 17 (5); 22.
Existing Cordyceps militaris (L.) Link. preparation mainly will be taked the decocting in water precipitate with ethanol after aquatic foods product Cordyceps militaris (L.) Link. drying or the lyophilization, the preparation of methods such as alcohol extracting-water precipitating, bright product Cordyceps militaris (L.) Link. is the mushroom class biology that adopts the fungus cultivation method to grow under the constant humidity condition, its water content reaches 83%, aquatic foods product Cordyceps militaris (L.) Link. oven dry to exsiccant dry product need be toasted long time, need to consume a lot of energy, the quality that the process temperature control instability of oven dry or non-uniform temperature all can influence the dry product Cordyceps militaris (L.) Link., as far back as Qin Hanyijia medicinal material drying processing is just recognized that exsiccant process reduces medical material quanlity, " herbal classic " is marked with " survivor is good ", and the definition of " life " of indication herein is " aquatic foods " just.
The content 9.48% of the catalpol in people's Radix Rehmanniae such as modern study has the feature of many digital proofs " survivor is good ", Li Jiping and the Radix Rehmanniae, the bright product Radix Rehmanniae of the comparison of carbohydrate content catalpol, the content 4.21% of dry product Radix Rehmanniae catalpol.The content 14.03% of the content 27.23% dry product Radix Rehmanniae reducing sugar of bright product Radix Rehmanniae reducing sugar, the content 9.02% of bright product Dihuang polysaccharide, the content 3.13% " Chinese Pharmaceutical Journal " of dry product Dihuang polysaccharide, 2001,36 (5); 300.
People's Radix Rehmanniae and the Radix Rehmanniae hemostasis and the effect comparative study of exempting from service such as beam Aiwa are divided into 3 groups with medicament; Radix Rehmanniae is smash juice group, Radix Rehmanniae decocting liquid group, Radix Rehmanniae decocting liquid group hemostasis drug action is respectively: Radix Rehmanniae is smash juice group＞Radix Rehmanniae decocting liquid group＞Radix Rehmanniae decocting liquid group, and Radix Rehmanniae is smash juice and obviously is better than Radix Rehmanniae decocting liquid.The influence of the inductive low Turnover of Mouse Peritoneal Macrophages phagocytic function of exempting from service of Dichlorodiphenyl Acetate prednisolone experimental results show that improving exempts from service and be subjected to that the macrophage phagocytic function fresh rehmannia root juice effect that presses down mice is the strongest." CHINA JOURNAL OF CHINESE MATERIA MEDICA " 1999,24 (11); 663 what is beautiful one, the Thin-layer separation of tropane alkaloid and assay in the Chinese plant of Solanaceae. fresh Herba Dendrobii total alkaloid content 1.62%, dendrobium chrysanthum total alkaloid content 0.6504%." Acta Pharmaceutica Sinica ", 1979,14 (7); 421.
Li Manfei etc., the saccharoidal mensuration of Chinese medicine Herba Dendrobii, the reducing sugar 15.96% of fresh Herba Dendrobii, dendrobium chrysanthum 5.04%." Chinese herbal medicine ", 1990,21 (10); 11.
The comparative study of the bright dendrobium chrysanthum part of people such as beam Aiwa, Xue Baoyun pharmacologically active, the influence of the inductive low Turnover of Mouse Peritoneal Macrophages phagocytic function of exempting from service of Dichlorodiphenyl Acetate prednisolone experimental results show that improving exempts from service and be subjected to that the macrophage phagocytic function fresh Herba Dendrobii effect that presses down mice is the strongest.Hao Jinda " research of bright medicine and application " People's Health Publisher 2003, P111.
People such as Han Shuping, Herba Eupatorii and belong to the research of the chemical composition of volatile oil of 3 kind of plant together, yield 2.4ml/kg, the yield 1.3ml/kg " CHINA JOURNAL OF CHINESE MATERIA MEDICA " of dry product volatile oil of Herba Eupatorii of bright product volatile oil of Herba Eupatorii, 1993,18 (1); 39.
The bright leaf of people Fructus Hippophaes such as Elaeocarpus decipiens monarch with dry in the shade the leaf bioactive substance relatively, removing free radical and active oxygen in order to avoid the total antioxidant capacity that causes lipid peroxidation, decompose hydroperoxide, blocking-up peroxidating chain and removed the bioactive substance evaluation indexes such as metal ion of catalytic action dries in the shade leaf than the bright leaf decline 30.2% of Fructus Hippophae." Fructus Hippophae " 1997,10 (3); 26.Experimental results show that bright product medical material produces the minimizing effective ingredient in the exsiccant process of baking and reduces bioactive influence.Even the bright product Cordyceps militaris (L.) Link. of experimental data that reduces according to the biological activity of the Folium Hippophae that dries in the shade adopts lyophilization also may lower the biological activity of aquatic foods product Cordyceps militaris (L.) Link..Lyophilization might alleviate high temperature the contained composition of Cordyceps militaris (L.) Link. is destroyed, but the energy that lyophilization consumed is more, and the technology cost is higher.
The present invention will provide a kind of drying process of exempting to extract bright product Cordyceps militaris (L.) Link. preparation of biological activity, preparation and the method thereof that bright product Cordyceps militaris (L.) Link. composition keeps bright product Cordyceps militaris (L.) Link. composition.
The present invention is achieved in that according to people such as Zhang Shulan " combination of Chinese and Western medicine magazine " 1985,5 (1), 45, people such as Zheng Youlan " Fujian medical magazine " 1983, (5), 55, people such as Wang Meiying " Chinese pathology can exempt from service the 4th national meeting paper data of pathology " 1988,51, people such as Wang Meiying " Shanghai Medical Univ's journal " 1989,16 (5) 261, pharmaceutical research adopts Cordyceps water extract to concentrate after the extract of 80% ethanol extraction can increase mononuclear cell, phagocyte surface FC receptor number, pair cell inner acidic phosphatase activity state does not have the activation transmission, this ability is the ADCC effect by the pair cell of FC receptor realization, Cordyceps water extract concentrates after the extract of 80% ethanol extraction can also participate in regulating the reaction of exempting from service by the IL-1 that stimulates the mouse peritoneal adherent cell to secrete high titre, and Cordyceps water extract concentrates after the extract of 80% ethanol extraction also may be by the mechanism of TLC complement properdin system at interior various cascade activation activated mononuclear macrophage systems.Above-mentioned experiment shows that the active component of Cordyceps adopts water or ethanol extraction drug effect to determine.
Chen Yan equality people " bulletin of Chinese materia medica ", 1983; 8 (5), 33, Cui Zhigui " Chinese herbal medicine " 1982,13 (1), 13, pharmaceutical research shows that also Cordyceps polysaccharide liquid can obviously improve colloid carbon clearance speed in the mice blood, increases Turnover of Mouse Peritoneal Macrophages phagocytic index and percentage rate, makes the liver spleen engulf coefficient numerical value significantly to increase.Experiment has proved that once more the Cordyceps active component adopts the feasibility of water or ethanol extraction.
Having adopted bright product Cordyceps militaris (L.) Link. according to the principle the present invention of " survivor is good " is raw material, aquatic foods product Cordyceps militaris (L.) Link. is trimmed to chip, containing 81.5% ethanol water by bright product Cordyceps militaris (L.) Link. and ethanol adding in 1: 9.5 soaks, with make it to contain ethanol 75% after moisture in the aquatic foods product Cordyceps militaris (L.) Link. mixes, soak beater making beating afterwards in 12 hours, with aquatic foods product Cordyceps militaris (L.) Link. and ethanol water in pulping process repeatedly be subjected to mix under the pressure action, the intracellular composition of bright product Cordyceps militaris (L.) Link. is dissolved by ethanol water, under the effect that is subjected to pressure, in cell, replace simultaneously to the extracellular, making beating mechanical movement is repeatedly replaced in ethanol water the intracellular composition of bright product Cordyceps militaris (L.) Link. fully, fully adopt the centrifuge centrifugalize that the fiber and the insoluble solidity thing of aquatic foods product Cordyceps militaris (L.) Link. are separated after the making beating, collect centrifugal liquid, centrifugal liquid adopts distilling under reduced pressure, reclaim ethanol in vacuum distillation process, steaming dewaters gets bright product Cordyceps militaris (L.) Link. dried cream powder.
Aquatic foods product Cordyceps militaris (L.) Link. dried cream powder is filled the promptly bright product Cordyceps militaris (L.) Link. of Capsules capsule.
Adopt dry granulation pack sealing promptly to get bright product Cordyceps militaris (L.) Link. electuary aquatic foods product Cordyceps militaris (L.) Link. dried cream powder.
Just bright product Cordyceps militaris (L.) Link. dried cream powder is dissolved in the pure water, be sub-packed in carafe is aquatic foods product cordycepin beverage.
Adopt above-mentioned its preparation method to prepare overall process and do not use heating, kept the biological activity of bright product Cordyceps militaris (L.) Link..
The aquatic foods product Cordyceps militaris (L.) Link. raw material that adopts the bright product Cordyceps militaris (L.) Link. of above-mentioned its preparation method preparation capsule, bright product Cordyceps militaris (L.) Link. electuary, aquatic foods product cordycepin beverage to be adopted need not be dried and lyophilization, energy savings, has alleviated labor intensity, has reduced production cost, has improved product quality.
Embodiment 1
The first step: get bright product Cordyceps militaris (L.) Link. 10KG;
Second step: be trimmed to chip (length≤1MM);
The 3rd step: add 95 liters of mixing of 81.5% edible ethanol, mix back adjustment concentration of alcohol and make it to contain ethanol 75%, soaked 12 hours;
The 4th step: beater making beating;
The 5th step: the centrifuge solid-liquid separation, separate the solidity thing;
The 6th step: distilling under reduced pressure (be decompressed to≤4Pa, temperature control≤36 ℃), reclaim ethanol, steam and remove moisture;
The 7th step: collect dried cream powder;
The 8th step: fill hollow in capsule;
The 9th step: bottling encapsulation (promptly bright product Cordyceps militaris (L.) Link. capsule).
Embodiment 2
The first step: get bright product Cordyceps militaris (L.) Link. 10KG;
Second step: be trimmed to chip (length≤1MM);
The 3rd step: add 95 liters of mixing of 81.5% edible ethanol, mix back adjustment concentration of alcohol and make it to contain ethanol 75%, soaked 12 hours;
The 4th step: beater making beating;
The 5th step: the centrifuge solid-liquid separation, separate the solidity thing;
The 6th step: distilling under reduced pressure (be decompressed to≤4Pa, temperature control≤36 ℃), reclaim ethanol, steam and remove moisture;
The 7th step: collect dried cream powder;
The 8th step: aquatic foods product Cordyceps militaris (L.) Link. dried cream powder is adopted dry granulation machine dry granulation;
The 9th step: be sub-packed in aluminium plastic packaging bag (every bag 2 gram);
The tenth step: packing encapsulation (promptly bright product Cordyceps militaris (L.) Link. electuary).
Embodiment 3
The first step: get bright product Cordyceps militaris (L.) Link. 10KG;
Second step: be trimmed to chip (length≤1MM);
The 3rd step: add 95 liters of mixing of 81.5% edible ethanol, mix back adjustment concentration of alcohol and make it to contain ethanol 75%, soaked 12 hours;
The 4th step: beater making beating;
The 5th step: the centrifuge solid-liquid separation, separate the solidity thing;
The 6th step: distilling under reduced pressure (be decompressed to≤4Pa, temperature control≤36 ℃), reclaim ethanol, steam and remove moisture;
The 7th step: collect dried cream powder;
The 8th step: by bright product Cordyceps militaris (L.) Link. dried cream powder and the dissolving of 1: 500 mixed of pure water;
The 9th step: filling bottle encapsulation (promptly bright product cordycepin beverage).
Claims (7)
1, bright product Cordyceps militaris (L.) Link. preparation is characterized in that raw material is bright product Cordyceps militaris (L.) Link..
2, by the described bright product Cordyceps militaris (L.) Link. preparation of claim 1, it is characterized in that capsule formulation.
3, by the described bright product Cordyceps militaris (L.) Link. preparation of claim 1, it is characterized in that the dissolved granule type.
4, by the described bright product Cordyceps militaris (L.) Link. preparation of claim 1, it is characterized in that the water preparation beverage.
5, bright product Cordyceps militaris (L.) Link. formulation preparation method is characterized in that bright Cordyceps militaris (L.) Link. shearing, soak with ethanol, making beating, solid-liquid separation, distilling under reduced pressure.
6, by the described bright product Cordyceps militaris (L.) Link. formulation preparation method of claim 5, the mixed solution ethanol content that it is characterized in that soak with ethanol is 75%.
7,, it is characterized in that distilling under reduced pressure is decompressed to≤4Pa, temperature control≤36 ℃ by the described bright product Cordyceps militaris (L.) Link. formulation preparation method of claim 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101166542A CN100402046C (en) | 2003-11-29 | 2003-11-29 | Fresh product of cordyceps militaris and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101166542A CN100402046C (en) | 2003-11-29 | 2003-11-29 | Fresh product of cordyceps militaris and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1621087A true CN1621087A (en) | 2005-06-01 |
| CN100402046C CN100402046C (en) | 2008-07-16 |
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| CNB2003101166542A Expired - Fee Related CN100402046C (en) | 2003-11-29 | 2003-11-29 | Fresh product of cordyceps militaris and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058002A (en) * | 2011-01-07 | 2011-05-18 | 大连工业大学 | Preparation method for cordyceps sinensis health protection tea |
| CN103932342A (en) * | 2014-04-28 | 2014-07-23 | 黑龙江华药生物科技有限公司 | Cordyceps militaris biowater and preparation method thereof |
| CN109123657A (en) * | 2018-09-14 | 2019-01-04 | 滁州学院 | A kind of processing method of the chewable tablets containing fresh Cordyceps militaris and drone pupae |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101571A (en) * | 1993-10-15 | 1995-04-19 | 张显科 | Technology for producing cordyceps militaris series products |
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2003
- 2003-11-29 CN CNB2003101166542A patent/CN100402046C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058002A (en) * | 2011-01-07 | 2011-05-18 | 大连工业大学 | Preparation method for cordyceps sinensis health protection tea |
| CN102058002B (en) * | 2011-01-07 | 2013-01-09 | 大连工业大学 | Preparation method for cordyceps sinensis health protection tea |
| CN103932342A (en) * | 2014-04-28 | 2014-07-23 | 黑龙江华药生物科技有限公司 | Cordyceps militaris biowater and preparation method thereof |
| CN109123657A (en) * | 2018-09-14 | 2019-01-04 | 滁州学院 | A kind of processing method of the chewable tablets containing fresh Cordyceps militaris and drone pupae |
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| Publication number | Publication date |
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| CN100402046C (en) | 2008-07-16 |
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Granted publication date: 20080716 Termination date: 20101129 |