CN1616445A - Method for synthesizing saturated fatty acid vitamin C ester - Google Patents
Method for synthesizing saturated fatty acid vitamin C ester Download PDFInfo
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- CN1616445A CN1616445A CN 200410078860 CN200410078860A CN1616445A CN 1616445 A CN1616445 A CN 1616445A CN 200410078860 CN200410078860 CN 200410078860 CN 200410078860 A CN200410078860 A CN 200410078860A CN 1616445 A CN1616445 A CN 1616445A
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- fatty acid
- saturated fatty
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- ester
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Abstract
The present invention provide method of synthesizing saturated fatty acid vitamin C ester. Under room temperature or low temperature, saturated fatty acid, vitamin C and concentrated sulfuric acid are mixed and reacted in ultrasonic field to synthesize saturated fatty acid vitamin C ester in relatively short time. The present invention has greatly shortened reaction period and raised yield. The synthesized saturated fatty acid vitamin C ester is used mainly as antioxidant for food, beverage, vegetable oil and high grade cosmetics, and may be used also as the nutrients reinforcing agent replenishing vitamin C.
Description
Technical field
The present invention relates to a kind of method of synthesizing saturated fatty acid vitamin C ester.
Background technology
Saturated fatty acid cetylate, particularly ascorbyl palmitate ester, stearic acid vitamin C ester, lauric acid vitamin C ester are as promptly having the antioxidant of health protection effect again safely and being extensive use of.
The synthetic method of saturated fatty acid vitamin C ester has traditional sulfuric acid process, hydrogen fluoride solvent method, chloride method and modern enzyme catalysis method.U.S. PFIZER company at first uses Production By Sulfuric Acid Process vitamin C fat acid esters, and process is simple, but the reaction times is longer, generally needs about 20 hours; The hydrogen fluoride solvent method exists toxicity and environmental problem; Chloride method carries out in two steps, and process is numerous and diverse, long reaction time, and yield is a little more than sulfuric acid process; The cleaning of enzyme catalysis method process, but the reaction times is longer, and industrialization output is difficult to promote the cost height.
Method provided by the invention is that sulfuric acid process is improved, and will have the sulfuric acid process reaction times now to reduce to 1 minute-3 hours by about 20 hours, has accelerated speed of response greatly, has improved production efficiency.
Summary of the invention
The object of the invention is to develop a kind of method of synthesizing saturated fatty acid vitamin C ester, this method is under room temperature or low temperature, saturated fatty acid, vitamins C, the vitriol oil are mixed, put into ultrasonic wave field and react, finish the synthetic of vitamin C ester within a short period of time.This method is that conventional sulfuric acid process is improved, and will have the sulfuric acid process reaction times now to reduce to 1 minute-3 hours by about 20 hours, has accelerated speed of response greatly, has improved production efficiency.
The method of a kind of synthesizing saturated fatty acid vitamin C ester of the present invention, this method is under room temperature or low temperature, saturated fatty acid, vitamins C, the vitriol oil are mixed, putting into ultrasonic wave field reacts, 1 minute-3 hours time, reaction mixture generates white precipitate in frozen water, behind routine extraction, drying process purifying, promptly get the product polyunsaturated fatty acid vitamin C ester; Wherein the ratio of each component is: saturated fatty acid 0.5-1.5 part, 1 part of vitamins C, vitriol oil 1-20 part.
Saturated fatty acid comprises from natural fats and oils coming and transforming the saturated fatty acid product, particularly carbon number that obtain saturated fatty acid product, especially lauric acid, palmitinic acid and the stearic acid from 1-32 by chemical process.
Vitriol oil concentration is 90-100%.
Ultrasonic frequency is 18-1000kHz, preferred 18-100kHz.
The synthetic saturated fatty acid vitamin C ester is applied to the oxidation inhibitor of food, beverage, plant oil and the cosmetics of super quality and ascorbic as a supplement nutrition-fortifying agent.
Embodiment
Embodiment 1
At room temperature, after 1 part of vitamins C, 1 part of mixing of 0.5 part of 90% vitriol oil of palmitinic acid, putting into the 100-kHz ultrasonic wave field reacts, 20 minutes time, reaction mixture generates white precipitate in frozen water, by conventional extracted with diethyl ether, drying, behind the normal hexane edulcoration purification, get product ascorbyl palmitate ester, fusing point 102-114 ℃, yield 51%.
Be mainly used in the oxidation inhibitor of food, beverage, plant oil and the cosmetics of super quality, and ascorbic as a supplement nutrition-fortifying agent.
Embodiment 2
Under the room temperature, after 1.5 parts of vitamins Cs, 1.0 parts of lauric acid, 10 parts of mixing of 95% vitriol oil, place the 40kHz ultrasonic field, reacted 50 minutes, reaction mixture generates white precipitate in frozen water, by extracted with diethyl ether, drying, behind the normal hexane edulcoration purification, get product lauric acid vitamin C ester, fusing point 104-117 ℃, yield 58%.
Be mainly used in the oxidation inhibitor of food, beverage, plant oil and the cosmetics of super quality, and ascorbic as a supplement nutrition-fortifying agent.
Embodiment 3
Under the room temperature, after 2 parts of vitamins Cs, 20 parts of mixing of 1.5 part of 98% vitriol oil of stearic acid, place the 60kHz ultrasonic field, reacted 1 minute, reaction mixture generates white precipitate in frozen water, by extracted with diethyl ether, drying, behind the normal hexane edulcoration purification, get product stearic acid vitamin C ester, yield 18%.
Be mainly used in the oxidation inhibitor of food, beverage, plant oil and the cosmetics of super quality, and ascorbic as a supplement nutrition-fortifying agent.
Embodiment 4
Under 0 ℃, after 1 part of vitamins C, 1.0 parts of lauric acid, 15 parts of mixing of 100% vitriol oil, place the 100kHz ultrasonic field, reacted 2 hours, reaction mixture generates white precipitate in frozen water, by extracted with diethyl ether, drying, behind the normal hexane edulcoration purification, get product lauric acid vitamin C ester, yield 67%.
Be mainly used in the oxidation inhibitor of food, beverage, plant oil and the cosmetics of super quality, and ascorbic as a supplement nutrition-fortifying agent.
Embodiment 5
Under 0 ℃, after 2 parts of vitamins Cs, 1.5 parts of palmitinic acids, 20 parts of mixing of 95% vitriol oil, place the 80kHz ultrasonic field, reacted 3 hours, reaction mixture generates white precipitate in frozen water, by extracted with diethyl ether, drying, behind the normal hexane edulcoration purification, get product ascorbyl palmitate ester, fusing point 107-114 ℃, yield 69%.
Be mainly used in the oxidation inhibitor of food, beverage, plant oil and the cosmetics of super quality, and ascorbic as a supplement nutrition-fortifying agent.
Claims (5)
1, a kind of method of synthesizing saturated fatty acid vitamin C ester, it is characterized in that this method is under room temperature or low temperature, saturated fatty acid, vitamins C, the vitriol oil are mixed, putting into ultrasonic wave field reacts, 1 minute-3 hours time, reaction mixture generates white precipitate in frozen water, behind routine extraction, drying process purifying, promptly get the product polyunsaturated fatty acid vitamin C ester; Wherein the ratio of each component is: saturated fatty acid 0.5-1.5 part, vitamins C 1-2 part, vitriol oil 1-20 part.
2, the method for synthesizing saturated fatty acid vitamin C ester according to claim 1, it is characterized in that saturated fatty acid comprises from natural fats and oils coming and transforming the saturated fatty acid product that obtains by chemical process, particularly carbon number is from saturated fatty acid product, especially lauric acid, palmitinic acid and the stearic acid of 1-32.
3, the method for synthesizing saturated fatty acid vitamin C ester according to claim 1 is characterized in that vitriol oil concentration is 90-100%.
4, the method for synthesizing saturated fatty acid vitamin C ester according to claim 1 is characterized in that ultrasonic frequency is 18-1000kHz, preferred 18-100kHz.
5, synthesizing saturated fatty acid vitamin C ester according to claim 1 is applied to the oxidation inhibitor of food, beverage, plant oil and the cosmetics of super quality and ascorbic as a supplement nutrition-fortifying agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410078860 CN1256333C (en) | 2004-09-09 | 2004-09-09 | Method for synthesizing saturated fatty acid vitamin C ester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410078860 CN1256333C (en) | 2004-09-09 | 2004-09-09 | Method for synthesizing saturated fatty acid vitamin C ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1616445A true CN1616445A (en) | 2005-05-18 |
| CN1256333C CN1256333C (en) | 2006-05-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410078860 Expired - Fee Related CN1256333C (en) | 2004-09-09 | 2004-09-09 | Method for synthesizing saturated fatty acid vitamin C ester |
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| CN (1) | CN1256333C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110128381A (en) * | 2019-06-14 | 2019-08-16 | 河北美荷药业有限公司 | A kind of preparation method of ascorbyl laurate |
-
2004
- 2004-09-09 CN CN 200410078860 patent/CN1256333C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110128381A (en) * | 2019-06-14 | 2019-08-16 | 河北美荷药业有限公司 | A kind of preparation method of ascorbyl laurate |
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| Publication number | Publication date |
|---|---|
| CN1256333C (en) | 2006-05-17 |
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