CN1613860A - Cephaene onium salt compound and its preparation, and synthesis of cephapyrazde sulfate therefrom - Google Patents
Cephaene onium salt compound and its preparation, and synthesis of cephapyrazde sulfate therefrom Download PDFInfo
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- CN1613860A CN1613860A CN 200310106953 CN200310106953A CN1613860A CN 1613860 A CN1613860 A CN 1613860A CN 200310106953 CN200310106953 CN 200310106953 CN 200310106953 A CN200310106953 A CN 200310106953A CN 1613860 A CN1613860 A CN 1613860A
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Abstract
This invention relates to cephalene onium salt compound and its preparation and synthesis of cephapyrazole sulfate therefrom. It is produced from 7beta-alkyl amido-3-[3-alkyl amido-2-(2-alkyl acyl oxethyl)-1-pyrazole onium group]methyl-3-cephalene- 4-carboxylic salt as intermediate by hydrolyzing it and reacting with alpha-(2-amino thiazole-4-radicle)-alpha-(Z)-methoxy imino acetic acid(benzo thiazole-2-radicle)hydrosulfate. The reacting condition is moderate, its raw materials can be obtained easily, and no expensive and strong irritant reagent is needed.
Description
Technical field
The invention belongs to the synthetic field of cephalosporins medicine, relate to a kind of cephalosporanic olefinic salt compound and preparation method thereof in particular, reaching with this compound is feedstock production cephalosporins medicine (-)-5-amino-2-[[(6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino) kharophen]-2-carboxyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene base-3-yl] methyl]-1-(2-hydroxyethyl)-1H-pyrazoles inner salt, monosulfate, the i.e. synthetic method of FK 037.
Background technology
The preparation of FK 037 once saw Japanese Fujisawa Pharmaceutical Co., Ltd slope root and husband, the Chinese patent (88106644.3) and the flat 4-173792 of Japanese Patent JP of auspicious great two reports in river.
It is starting raw material that Chinese patent 88106644.3 adopts with 7-tertiary butyloxycarbonyl amino-3-chloromethyl-3-cephem-4-carboxylic acid benzhydryl ester, through forming three bit substituents with the reaction of 5-formamido group-1-(2-methanoyl ethyl) pyrazoles, after forming the substituting group of 7-position with the reaction of α-(2-formamido group thiazole-4-yl)-α-(Z)-methoxyimino Acetyl Chloride 98Min. again, finally make the method for cephalo pyrazoles.The sodium iodide that uses in this method, silane amide reagent price are expensive, use when going up simultaneously seven bit substituents the bigger halide reagent of pungency and corrodibility (as, phosphorus pentachloride, phosgene etc.).
The flat 4-173792 of Japanese Patent JP is to be starting raw material and 1-((Z)-α-(thiazolamine-4-yl)-α-methoxy acetimidoyl) benzotriazole-3-oxide compound prepared in reaction cephalo pyrazoles with 7 beta-aminos-3-(3-amino-2-(2-hydroxyethyl)-1-pyrazoles subbase) methyl-3-cephem-4-carboxylic acid.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, i.e. intermediate 7 β-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl the ethyl)-1-pyrazolyl of synthetic FK 037 of a kind of cephalosporanic olefinic salt compound be provided] methyl-3-cephem-4-carboxylate compounds (I).
Another object of the present invention is to provide a kind of 7 β-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl] synthetic method of methyl-3-cephem-4-carboxylate compounds (I).
It is a kind of with 7 β-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl that a further object of the present invention is to provide] methyl-3-cephem-4-carboxylate compounds (I) is that raw material is after hydrolysis, with the synthetic method of α-(thiazolamine-4-yl)-α-(Z)-methoxyimino acetate (benzothiazole-2-yl) thiol esters (being called for short the AE active ester) prepared in reaction FK 037.
A kind of cephalosporanic olefinic salt compound with following formula
Its chemical structure of general formula is represented with (I):
The The compounds of this invention name is called 7 β-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylate salt.
R wherein
1, R
2, R
3Expression hydrogen, low carbon chain alkyl are as methyl, ethyl or propyl group, R
1, R
2, R
3Be preferably hydrogen, methyl, ethyl; N is 0 or 1, when n represents 0, and R
4Be COO
-, when n represents 1, R
4Carboxyl for COOH or protection; X
-The expression negatively charged ion: negatively charged ion is the negatively charged ion from the reactant leavings group, it also can be another negatively charged ion that is transformed thus with ordinary method, another organic acid or the inorganic anion that are preferably cl anion or can be transformed with it are as acetate moiety, tosylate, trifluoroacetic acid root, bromine anions, bisulfate ion or phosphate radical etc.
7 β-(alkyl amido)-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl] synthetic method of methyl-3-cephem-4-carboxylate salt (I) may further comprise the steps:
(1). according to a conventional method, 7 beta-aminos-3-chloromethyl-3-cephem-4-carboxylic acid to methoxybenzyl ester hydrochloride (II), is carried out the protection of 7 β bit amino acidylates, make 7 β-alkyl amido-3-chloromethyl-3-cephem-4-carboxylic acid methoxybenzyl ester (III).
(2). according to a conventional method,, carry out the reaction of 4-position decarboxylation protecting group, make 7 β-alkyl amido-3-chloromethyl-3-cephem-4-carboxylic acid (IV) compound (III).
(3). with compound (IV) and 5-alkyl amido-1-(2-alkyloyloxyethyl ethyl) pyrazoles (VII), and suitable alkali in the presence of organic solvent, react in certain proportion make 7 β-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylate salt (I).
Compound IV: compound VI I: alkali: the mol ratio of organic solvent is generally 1: 1-10: 0.1-10: 1-40 (w/v) is preferably 1: 1-6: 0.2-6: 2-10 (w/v), preferred 1: 1-4: 0.3-4: 2-6 (w/v); Temperature of reaction generally at-20～60 ℃, is preferably-5-35 ℃, and preferred 5-30 ℃; Reacted 1/6～20 hour, and be preferably 1/2～8 hour; Suitable organic solvent comprises aromatic hydrocarbons such as toluene, dimethylbenzene; Halohydrocarbon such as methylene dichloride, chloroform; Ethers such as tetrahydrofuran (THF), dioxane; Alcohols such as methyl alcohol, ethanol, n-propyl alcohol, Virahol, propyl carbinol, the trimethyl carbinol; Sulfone class such as dimethyl sulfoxide (DMSO), tetramethylene sulfone; Ester class such as ethyl acetate, butylacetate; Amides such as dimethyl formamide, N,N-DIMETHYLACETAMIDE; And ketone such as acetone, methylethylketone, butanone, preferably ethers, sulfone class, amides and ketones solvent.Suitable alkali is generally inorganic or organic bases, as basic metal and alkaline earth metal hydroxides such as sodium hydroxide, potassium hydroxide, basic metal or alkaline earth metal carbonate such as salt of wormwood, yellow soda ash and lime carbonate, and alkali metal hydrocarbonate such as sodium bicarbonate, saleratus etc., organic bases is generally sodium acetate etc.
With 7 β-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl] synthetic (-)-5-amino-2-[[(6R of methyl-3-cephem-4-carboxylate salt (I), 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino) kharophen]-2-carboxyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene base-3-yl] methyl]-1-(2-hydroxyethyl)-1H-pyrazoles inner salt, monosulfate (VI), be the synthetic method of FK 037, this method may further comprise the steps:
(1) at ambient temperature, (I) with alcohol and concentrated hydrochloric acid reaction, its proportioning is 1: 1～20: 1～10, stirring reaction 1～6 hour, mixture is added drop-wise in the ethyl acetate that is equivalent to 1～80 times of compound (I) quality, makes 7 beta-aminos-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylic acid chloride hydrochloride (V).
(2) with compound (V), water and dimethyl formamide mix by 1: 2～20: 2～20 (W/V), add α-(thiazolamine-4-the yl)-α be equivalent to 1～2 times of compound (V) molar mass-(Z)-methoxyimino acetate (benzothiazole-2-yl) thiol esters and (call the AE active ester in the following text, VIII), transfer reaction solution pH to neutral with suitable alkali, react after 0.5-4 hour, transfer pH=1 with dilute sulphuric acid, the reaction solution impouring is equivalent in the organic solvent of 2～100 times of compound (V) weight, in preferred 2～60 times of organic solvents, separate out white crystals (-)-5-amino-2-[[(6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino) kharophen]-2-carboxyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene base-3-yl] methyl]-1-(2-hydroxyethyl)-1H-pyrazoles inner salt, monosulfate, i.e. FK 037 (VI).
Suitable alkali is generally inorganic or organic bases, as basic metal and alkaline earth metal hydroxides such as sodium hydroxide, potassium hydroxide, basic metal or alkaline earth metal carbonate such as salt of wormwood, yellow soda ash and lime carbonate, and alkali metal hydrocarbonate such as sodium bicarbonate, saleratus or the like, organic bases is generally triethylamine, pyridine, TERTIARY BUTYL AMINE etc., particularly preferably is sodium hydroxide, sodium bicarbonate, yellow soda ash, triethylamine, pyridine etc.Suitable organic solvent is ditto described.
7 β of the present invention-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylate salt (I) and be synthetic (-)-5-amino of intermediate-2-[[(6 R with this compound, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino) kharophen]-2-carboxyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene base-3-yl] methyl]-1-(2-hydroxyethyl)-1H-pyrazoles inner salt, monosulfate compound (VI), promptly the synthetic route of FK 037 is as follows:
R
1, R
2, R
3Expression hydrogen, methyl or ethyl;
R
4b=-COOH; R
4c=-COOH or-COO
-N=0,1, na=0,1,2,3;
X
-Negatively charged ion is the negatively charged ion from the reactant leavings group, also can be another negatively charged ion that is transformed thus with ordinary method.
The present invention adopts sulfo-active ester (VIII) cheap and easy to get to carry out seven acylation reactions, and reaction conditions gentleness, by product easily reclaim, and the three wastes are handled easily.Pungencys such as Phosphorates phosphorus Halides, phosgene, special reagent that corrodibility is big have been avoided using.Simultaneously at synthetic The compounds of this invention 7 β-alkyl amido-3-[3-alkyl amido-2-(2-alkyloyloxyethyl ethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylate salt (I) and this during as intermediate synthetic FK 037 (VI), also be need not to use price sodium iodide, the silane amide reagent of costliness.Therefore the inventive method reaction conditions gentleness need not be used special reagent, products obtained therefrom purity height, easy, the easy row of reaction scheme.
Embodiment
The initial substance of preparation The compounds of this invention and intermediate all can have been bought (as compound VIII) from the market or easily make by known method.Can make with reference to the preparation method of Chinese patent 00121531.0 as compound (II), compound (VII) can make with reference to the preparation method of Chinese patent 88106644.3.
The present invention is further illustrated below in conjunction with embodiment, and embodiment only is indicative, means that never it limits the scope of the invention by any way.
Prepare of the preparation of 1.7 β-formamido group-3-chloromethyl-3-cephem-4-carboxylic acid to methoxybenzyl ester (III-a):
Get 7 beta-aminos-3-chloromethyl-3-cephem-4-carboxylic acid to methoxybenzyl ester hydrochloride (II) 60g, tetrahydrofuran (THF) 120ml, join successively in the reaction flask of 250ml, ice bath drips triethylamine 20.5ml down, drip and finish, remove ice bath, stirring at room 1 hour is filtered, tetrahydrofuran (THF) 60ml divides three washings, and filtrate is stand-by.
In another 250ml reaction flask, add formic acid 27.3ml, diacetyl oxide 68.4ml, in 40～50 ℃ of stirring reactions 1 hour, filter, with above-mentioned stand-by filtrate impouring, separate out light yellow crystallization, continue at 45 ℃, insulation reaction 1 hour, cooling, ice bath stirred 1 hour, filtered, ethanol is washed, and gets 38.1g off-white color solid chemical compound (III-a).
1H-NMR(DMSO-d
6)δ3.67(2H，ABq)、3.78(3H，S)、4.55(2H，bs)、5.22(1H，d)、5.27(2H，S)、5.87(1H，dd)、6.97(2H，D)、8.16(1H，S)、9.10(1H，d)。
IR(KBr，Max)：1775、1719、1647cm
-1
Prepare of the preparation of 2.7 β-acetylaminohydroxyphenylarsonic acid 3-chloromethyl-3-cephem-4-carboxylic acid to methoxybenzyl ester (III-b):
Get 7 beta-aminos-3-chloromethyl-3-cephem-4-carboxylic acid to methoxybenzyl ester hydrochloride (II) 20g, tetrahydrofuran (THF) 40ml, join successively in the reaction flask of 100ml, ice bath drips triethylamine 6.83ml down, drip and finish, remove ice bath, stirring at room 1 hour is filtered, tetrahydrofuran (THF) 5ml * 3 washings, filtrate is stand-by.
With above-mentioned gained filtrate and diacetyl oxide 18.3ml, pyridine 7.8ml joins in the reaction flask successively, under 25 ℃, mixture was stirred 2 hours, reaction mixture is added in the mixture of aqueous solution 200ml of ethyl acetate 200ml and sodium-chlor, then to the pH=7 that wherein adds the sodium bicarbonate aqueous solution regulator solution, water layer is with the mixture extraction of ethyl acetate and tetrahydrofuran (THF), extraction liquid anhydrous magnesium sulfate drying, remove by filter sal epsom, filtrate evaporated under reduced pressure is got solid (III-b) 14.4g.
IR(KBr，Max)：1781、1729、1657、1514、1381cm
-1
The preparation for preparing 3.7 β-formamido group-3-chloromethyl-3-cephem-4-carboxylic acid (IV-a):
With 7 β-formamido group-3-chloromethyl-3-cephem-4-carboxylic acid to methoxybenzyl ester (III) 35g, methylene dichloride 105ml, methyl-phenoxide 35ml adds in the 500ml reaction flask successively, ice bath drips trifluoroacetic acid 135ml down, stir after 1 hour under the room temperature, reaction solution is poured in the mixed solution of isopropyl ether 400ml and ethyl acetate 400ml, filtered and collect the throw out that produces, get off-white color solid chemical compound (IV-a) 16.1g.
1H-NMR(100HZ，DMSO)δ：3.63(2H，ABq)、4.55(2H，S)、5.15(1H，d)、5.79(1H，m)、8.12(1H，S)、9.10(1H，d)。
Preparation 4. is by preparing 7 β-acetylaminohydroxyphenylarsonic acid 3-chloromethyl-3-cephem-4-carboxylic acid (IV-b) with preparation 4 similar methods.
Embodiment 1
7 β-formamido group-3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] preparation of methyl-3-cephem-4-carboxylate salt (I-a):
In the 250ml reaction flask, add compound 7 β-formamido group-3-chloromethyl-3-cephem-4-carboxylic acid (IV-a) 50g successively, dimethyl formamide 200ml, sodium bicarbonate 30g, and 5-formamido group-1-(2-methanoyl ethyl) pyrazoles (VIII) 99g, after the stirring at room 5 hours, filter, in filtrate impouring 2000ml ethyl acetate, filter, collect the throw out that produces, get light yellow solid compound (I-a) 75g.
IR(KBr，Max)：3423、1770、1632、1574cm
-1
m/e：424[M-H]
+
Embodiment 2
7 β-acetylaminohydroxyphenylarsonic acid 3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] preparation of methyl-3-cephem-4-carboxylate salt (I-b):
In the 250ml there-necked flask, add 7 β-acetylaminohydroxyphenylarsonic acid 3-chloromethyl-3-cephem-4-carboxylic acid 20g successively, tetramethylene sulfone 40ml, yellow soda ash 7.2g, and 5-formamido group-1-(2-methanoyl ethyl) pyrazoles (VII) 15.5g, stirring at room was filtered after 2 hours, in filtrate impouring 800ml acetone, filter, collect the throw out that produces, get light yellow solid compound (I-b) 29g.
IR(KBr，cm
-1)：
Embodiment 3
7 beta-aminos-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolyl] preparation of methyl-3-cephem-4-carboxylic acid chloride hydrochloride (V):
At room temperature, concentrated hydrochloric acid 23ml is added compound 7 β-formamido group-3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] in the mixture of methyl-3-cephem-4-carboxylate salt (I-a) 20g and methyl alcohol 100ml, under same temperature, stir after 2 hours, mixture is added drop-wise among the ethyl acetate 200ml, separates out the near-white solid, filter, an amount of ethyl acetate washing gets white solid compound (V) 17g.
1H-NMR(D
2O)δ：3.16-3.31(6H，m)，3.57-3.60(2H，t)，4.09-4.37(2H，m)，
4.85(1H，d)，5.01(1H，d).5.06-5.28(2H，g)，5.87(1H，d)，
7.38(2H，s)，8.00(1H，d)
IR(KBr，cm
-1)：3413，1786，1636，1592
m/e：340[M-H]
+
Embodiment 4
7 beta-aminos-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolyl] preparation of methyl-3-cephem-4-carboxylic acid chloride hydrochloride (V):
At room temperature, concentrated hydrochloric acid 14ml is added compound 7 β-(kharophen)-3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] in the mixture of methyl-3-cephem-4-carboxylate salt (I-b) 20g and methyl alcohol 80ml, under same temperature, stir after 4 hours, mixture is added drop-wise among the acetone 200ml, separates out the near-white solid, filter, the proper amount of acetone washing gets white solid compound (V) 15g.
Analytical data is seen embodiment 3
Embodiment 5
(-)-5-amino-2-[[(6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino) kharophen]-2-carboxyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene base-3-yl] methyl]-1-(2-hydroxyethyl)-1H-pyrazoles inner salt, monosulfate compound (VI), the i.e. preparation of FK 037:
With compound 7 beta-aminos-3-[3-amino-2-(2-hydroxyethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylic acid chloride hydrochloride (V) 20g, the mixture of water 60ml, dimethyl formamide 60ml, add AE active ester 18g, room temperature reaction 3 hours is used NaHCO in the reaction process
3It is neutral transferring reaction solution, and reaction is finished, and filters, and filtrate is transferred pH=1 with sulphuric acid soln, then, reaction solution slowly in the impouring 1L acetone, is separated out the off-white color crystallization, filter, and the proper amount of acetone washing, drying gets FK 037 (VI) 27g after water-alcohol processing again.
IR(KBr，Max)：3217、1771、1661、1606、1036cm
-1
1H-NMR(DMSO-d
6)δ：
3.19-3.33(2H，g)，3.57-3.60(2H，m)，3.82(3H，s)，4.03-4.33(2H，m)，
5.10-5.31(2H，g)，5.16-5.17(1H，d)，5.80-5.82(1H，m)，5.89-5.90(1H，d)，
6.74(1H，s)，7.34-7.40(4H，m)，7.98-7.99(1H，d)，9.64-9.66(1H，d)
m/e：621[M+H]
+
Ultimate analysis: C
19H
22N
8O
6S
2H
2SO
4
The calculated value measured value
C 36.77 36.65
H 3.90 3.77
N 18.05 17.94
S 15.50 15.39
Embodiment 6:
7 β-formamido group-3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] preparation of methyl 3-cephem-4-carboxylic acid (I-a) hydrochloride:
In reaction flask, add embodiment 1 gained compound 10 grams, 60 milliliters in water.Under the ice bath, drip 3.7 milliliters of concentrated hydrochloric acids.Behind the stirring reaction 5 minutes, lyophilize is washed through ethanol, makes title compound after the drying.
Embodiment 7:
7 β-formamido group-3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] preparation of methyl-3-cephem-4-carboxylic acid (I-a) tosilate:
Replace concentrated hydrochloric acid with reference to embodiment 6 similar methods with the tosic acid aqueous solution, make title compound.
Embodiment 8:
7 β-formamido group-3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] preparation of methyl-3-cephem-4-carboxylic acid (I-a) trifluoroacetate:
Replace concentrated hydrochloric acid with reference to embodiment 6 similar methods with trifluoroacetic acid, make title compound.
Claims (8)
1, a kind of cephalosporanic olefinic salt compound with following formula
Shown in general formula I
Wherein:
n＝0，1
When n represents 0, R
4Expression COO
-
When n represents 1, R
4The carboxyl of expression COOH or protection;
R
1, R
2, R
3Expression hydrogen, C
1-C
3Alkyl;
X
-The expression negatively charged ion: negatively charged ion is the negatively charged ion that comes the autoreaction leavings group, also can be another negatively charged ion that is transformed thus with ordinary method.
2, compound according to claim 1 is characterized in that described R
1, R
2, R
3Be hydrogen, methyl, ethyl or propyl group; X
-Expression negatively charged ion: can be cl anion or another organic acid or the inorganic anion that can be transformed with it.
3, compound according to claim 2, chemical name are 7 β-formamido group-3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylate salt.
4, compound according to claim 2, chemical name are 7 β-acetylaminohydroxyphenylarsonic acid 3-[3-acetylaminohydroxyphenylarsonic acid 2-(2-acetyl oxygen ethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylate salt.
5, compound according to claim 2, chemical name are 7 β-acetylaminohydroxyphenylarsonic acid 3-[3-formamido group-2-(2-methanoyl ethyl)-1-pyrazolyl] methyl-3-cephem-4-carboxylate salt.
6, the preparation method of the described compound of claim 2 is characterized in that making compound IV to react with compound VI I in suitable alkaline medium, the preparation Compound I
R
1, R
2, R
3Expression hydrogen, methyl or ethyl; R
4b=COOH.
7, according to the preparation method of the described compound of claim 5, it is characterized in that compound IV and compound VI I, reaction in the presence of alkali, its mol ratio IV: VII: alkali is 1: 1～10: 0.1～10.
8, a kind of is the preparation method of the synthetic FK 037 of raw material with compound (I), it is characterized in that:
A) make Compound I carry out deprotection reaction synthetic compound V;
B) compound V carries out the synthetic FK 037 (VI) of substitution reaction with certain proportion and compound VIII under conditions such as organic or inorganic solvent.
na＝0，1，2，3
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101230069B (en) * | 2006-12-31 | 2010-12-08 | 山东轩竹医药科技有限公司 | Novel cephalosporin derivant |
| CN101993450A (en) * | 2010-11-03 | 2011-03-30 | 湖南欧亚生物有限公司 | Preparation method of cefoselis sulfate |
| CN102827190A (en) * | 2011-06-14 | 2012-12-19 | 江苏豪森医药集团连云港宏创医药有限公司 | Cefoselis sulfate intermediate and preparation method thereof |
| CN103044454A (en) * | 2011-10-14 | 2013-04-17 | 四川科伦药业股份有限公司 | Method for synthesizing cefoselis sulfate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE63094B1 (en) * | 1987-09-14 | 1995-03-22 | Fujisawa Pharmaceutical Co | Cephem compound and a process for preparation thereof |
| JPH04173792A (en) * | 1990-11-02 | 1992-06-22 | Fujisawa Pharmaceut Co Ltd | Production of cephalosporin compound |
-
2003
- 2003-11-07 CN CNB2003101069538A patent/CN1321109C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101230069B (en) * | 2006-12-31 | 2010-12-08 | 山东轩竹医药科技有限公司 | Novel cephalosporin derivant |
| CN101993450A (en) * | 2010-11-03 | 2011-03-30 | 湖南欧亚生物有限公司 | Preparation method of cefoselis sulfate |
| CN101993450B (en) * | 2010-11-03 | 2011-11-30 | 湖南欧亚生物有限公司 | Preparation method of cefoselis sulfate |
| CN102827190A (en) * | 2011-06-14 | 2012-12-19 | 江苏豪森医药集团连云港宏创医药有限公司 | Cefoselis sulfate intermediate and preparation method thereof |
| CN103044454A (en) * | 2011-10-14 | 2013-04-17 | 四川科伦药业股份有限公司 | Method for synthesizing cefoselis sulfate |
| CN103044454B (en) * | 2011-10-14 | 2016-04-13 | 四川科伦药业股份有限公司 | A kind of synthetic method of cefoselis sulfate |
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