CN1597610A - Hydroxy apatite hollow microsphere and its preparation method - Google Patents
Hydroxy apatite hollow microsphere and its preparation method Download PDFInfo
- Publication number
- CN1597610A CN1597610A CN 200410035768 CN200410035768A CN1597610A CN 1597610 A CN1597610 A CN 1597610A CN 200410035768 CN200410035768 CN 200410035768 CN 200410035768 A CN200410035768 A CN 200410035768A CN 1597610 A CN1597610 A CN 1597610A
- Authority
- CN
- China
- Prior art keywords
- hydroxyapatite
- fusion
- tiny balloon
- seasoning
- ball
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
A bioactive degradable hollow hydroxy apatite microball used as carrier is prepared from porous hydroxy apatite particles through plasma fusing, spraying it in low-temp medium, natural drying, washing, ultrasonic dispersing and collecting.
Description
Technical field
The invention belongs to field of biomedical materials, particularly relate to a kind of biological activity hydroxyapatite tiny balloon that is used for fields such as slow releasing carrier of medication, bone impairment renovation material, Separation ﹠ Purification medium and preparation method thereof.
Technical background
Hydroxyapatite has excellent biological safety and biological activity, has obtained clinical application effect preferably as the bioactive coating of planting body, the damaged packing material of bone etc.With respect to other material, the hydroxylapatite biology consistency is good, and chemical property is stable, does not produce objectionable impurities after dissolving and the degraded, thereby has caused people's attention in the application in fields such as medicine controlled release carrier and biological substance Separation ﹠ Purification medium.But it is that pore texture is single as the main drawback of slow releasing carrier of medication, and biodegradation rate is low, causes medicine carrying ability and release kinetics all undesirable, and solid support material is difficult to degradation in vivo and disappears.Packing material as the bone defect repair also exists biodegradation rate low, and particularly some particles filled thing long period after implantation still is difficult to and organizes fully merge, and has the hidden danger of bringing out untoward reaction.Need further to improve as absorption, its surface property of Separation ﹠ Purification medium.For improving the biological degradability of hydroxyapatite, people attempt adopting the low temperature synthesis method to prepare the low-crystallinity hydroxyapatite; For improving release kinetics, the method that has human to add polymer substance prepares porous microsphere.For example: " Biomaterials " 2002 23 volume reports prepare porous microsphere etc. with interpolation gelatin, " J Mater Sci:Mater Med " 2002 13 volume reports with the way of adding chitosan.Though these methods have improved hydroxyapatite performance in a certain respect to a certain extent, but still be difficult to satisfy higher clinical and actual needs.
Summary of the invention
The objective of the invention is to overcome above-mentioned the deficiencies in the prior art, hydroxyapatite tiny balloon that a kind of biological degradability, absorption property, medicine carrying ability and release power learns well and preparation method thereof is provided.
The present invention realizes in the following manner:
A kind of hydroxyapatite tiny balloon, central hollow in the ball is characterized in that: be furnished with on the ball wall of tiny balloon with ball in the aperture of hollow position UNICOM, sphere diameter is 20-200 μ m, wherein the average crystallite degree of hydroxyapatite is 30-60%.
The preparation method of above-mentioned hydroxyapatite tiny balloon, realize by following steps:
(1) with granularity is the mixture of ice and water that the hydroxyapatite porous particle of 20-200 μ m sprays into the dual distilled water of mobile after with the plasma spraying equipment fusion in clean room; The processing condition of plasma fusion are: power is 35-45kW, and jet length is 300-500mm, and powder feeding rate is 20-40g/min;
(2) elimination frozen water is treated to collect after the seasoning of fusion particle;
(3) molten particles after will collecting cleans with dehydrated alcohol, disperses with the sonic oscillation method after the seasoning, and the powder that obtains is stand-by after by service requirements classification, packing, sterilization.
This powder promptly is made up of hydroxyapatite micro-sphere, and wherein the particle more than 60% is a hollow ball, and the hollow ball more than 50% has the ball wall of microporeization.Wherein the average crystallite degree of hydroxyapatite is lower than 60%.This microballoon has higher biodegradation rate and bigger specific surface area and multi-level pore texture, thereby can become preparation or directly as the important materials of high-performance medicine controlled release carrier, the damaged weighting material of bone and separation and purification medium.
Embodiment
Provide two embodiment of the present invention below:
Embodiment one
(1) with granularity is the hydroxyapatite porous particle of 20-80 μ m sprays into the dual distilled water of mobile after plasma fusion mixture of ice and water.The processing condition of plasma fusion are: power is 35kW, and jet length is 300-350mm, and powder feeding rate is 20-30g/min;
(2) elimination frozen water is treated to collect after the seasoning of fusion particle;
(3) molten particles after will collecting cleans with dehydrated alcohol, disperses with the sonic oscillation method after the seasoning, and the powder that obtains is stand-by after by service requirements classification, packing, sterilization.
The diameter of obtained tiny balloon is 20-90 μ m, and wherein the particle more than 70% is a hollow ball, and the hollow ball more than 50% has the ball wall of microporeization, and wherein the average crystallite degree of hydroxyapatite is lower than 50%.
Example two
(1) with granularity is the hydroxyapatite porous particle of 120-200 μ m sprays into the dual distilled water of mobile after plasma fusion mixture of ice and water.The processing condition of plasma fusion are: power is 45kW, and jet length is 400-450mm, and powder feeding rate is 30-40g/min;
(2) elimination frozen water is treated to collect after the seasoning of fusion particle;
(3) molten particles after will collecting cleans with dehydrated alcohol, disperses with the sonic oscillation method after the seasoning, and the powder that obtains is stand-by after by service requirements classification, packing, sterilization.
The diameter of obtained tiny balloon is 100-200 μ m, and wherein the particle more than 60% is a hollow ball, and the hollow ball more than 50% has the ball wall of microporeization, and wherein the average crystallite degree of hydroxyapatite is lower than 60%.
Claims (2)
1, a kind of hydroxyapatite tiny balloon, the microballoon central hollow is characterized in that, be furnished with on the ball wall of tiny balloon with ball in the aperture of hollow position UNICOM, sphere diameter is 20-200 μ m, wherein the average crystallite degree of hydroxyapatite is 30-60%.
2, the method for preparing the described hydroxyapatite tiny balloon of claim 1 is characterized in that may further comprise the steps:
(1) with granularity is the mixture of ice and water that the hydroxyapatite porous particle of 20-200 μ m sprays into the dual distilled water of mobile after with the plasma spraying equipment fusion in clean room; The processing condition of plasma fusion are: power is 35-45kW, and jet length is 300-500mm, and powder feeding rate is 20-50g/min;
(2) elimination frozen water is treated to collect after the seasoning of fusion particle;
(3) molten particles after will collecting cleans with dehydrated alcohol, disperses with the sonic oscillation method after the seasoning, and the powder that obtains is stand-by after by service requirements classification, packing, sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410035768 CN1597610A (en) | 2004-09-22 | 2004-09-22 | Hydroxy apatite hollow microsphere and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410035768 CN1597610A (en) | 2004-09-22 | 2004-09-22 | Hydroxy apatite hollow microsphere and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1597610A true CN1597610A (en) | 2005-03-23 |
Family
ID=34664324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410035768 Pending CN1597610A (en) | 2004-09-22 | 2004-09-22 | Hydroxy apatite hollow microsphere and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1597610A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398433C (en) * | 2006-08-09 | 2008-07-02 | 山东大学 | Preparation method of hydroxy phosephorite hollow microball |
| WO2008131676A1 (en) * | 2007-04-27 | 2008-11-06 | Huazhong University Of Science And Technology | Apparatus for preparing ca-p biomaterial by purification method of dialysis and separation |
| CN101862630A (en) * | 2010-06-29 | 2010-10-20 | 西安理工大学 | Preparation method of hydroxyapatite hollow microsphere in core/shell composite structure |
| CN101249284B (en) * | 2008-03-18 | 2013-06-19 | 中国科学院上海硅酸盐研究所 | Biological medical nano hollow ellipsoid and preparation method and application thereof |
| CN113262330A (en) * | 2021-07-06 | 2021-08-17 | 上海大学 | Sodium alginate/collagen composite bone scaffold and preparation method and application thereof |
-
2004
- 2004-09-22 CN CN 200410035768 patent/CN1597610A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100398433C (en) * | 2006-08-09 | 2008-07-02 | 山东大学 | Preparation method of hydroxy phosephorite hollow microball |
| WO2008131676A1 (en) * | 2007-04-27 | 2008-11-06 | Huazhong University Of Science And Technology | Apparatus for preparing ca-p biomaterial by purification method of dialysis and separation |
| CN101249284B (en) * | 2008-03-18 | 2013-06-19 | 中国科学院上海硅酸盐研究所 | Biological medical nano hollow ellipsoid and preparation method and application thereof |
| CN101862630A (en) * | 2010-06-29 | 2010-10-20 | 西安理工大学 | Preparation method of hydroxyapatite hollow microsphere in core/shell composite structure |
| CN101862630B (en) * | 2010-06-29 | 2012-07-18 | 西安理工大学 | Preparation method of hydroxyapatite hollow microsphere in core/shell composite structure |
| CN113262330A (en) * | 2021-07-06 | 2021-08-17 | 上海大学 | Sodium alginate/collagen composite bone scaffold and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Aktürk et al. | Fabrication of antibacterial polyvinylalcohol nanocomposite mats with soluble starch coated silver nanoparticles | |
| Jayakumar et al. | Fabrication of chitin–chitosan/nano ZrO2 composite scaffolds for tissue engineering applications | |
| Yao et al. | Microcapsules/microspheres related to chitosan | |
| Jayakumar et al. | Fabrication of chitin–chitosan/nano TiO2-composite scaffolds for tissue engineering applications | |
| Kumar | Nano-TiO 2 doped chitosan scaffold for the bone tissue engineering applications | |
| Zhang et al. | Surfactant-assisted sonochemical synthesis of hollow calcium silicate hydrate (CSH) microspheres for drug delivery | |
| Safi et al. | Mesoporous and hollow hydroxyapatite nanostructured particles as a drug delivery vehicle for the local release of ibuprofen | |
| Iqbal et al. | Microwave synthesis, characterization, bioactivity and in vitro biocompatibility of zeolite–hydroxyapatite (Zeo–HA) composite for bone tissue engineering applications | |
| Osuchukwu et al. | Synthesis techniques, characterization and mechanical properties of natural derived hydroxyapatite scaffolds for bone implants: A review | |
| Lei et al. | The effect of antibacterial ingredients and coating microstructure on the antibacterial properties of plasma sprayed hydroxyapatite coatings | |
| Ma et al. | Recent progress on fabrication of calcium-based inorganic biodegradable nanomaterials | |
| WO2016027110A1 (en) | Porous and non-porous bodies | |
| CN1597610A (en) | Hydroxy apatite hollow microsphere and its preparation method | |
| Li et al. | Improving the corrosion resistance and osteogenic differentiation of ZK60 magnesium alloys by hydroxyapatite/graphene/graphene oxide composite coating | |
| Heydari et al. | Fabrication of multicomponent cellulose/polypyrrole composed with zinc oxide nanoparticles for improving mechanical and biological properties | |
| Liu et al. | Physicochemical properties and antibacterial activity of gellan gum incorporating zinc oxide/carbon nanotubes bionanocomposite film for wound healing | |
| Nasiri et al. | Fabrication and evaluation of poly (vinyl alcohol)/gelatin fibrous scaffold containing ZnO nanoparticles for skin tissue engineering applications | |
| Manjubaashini et al. | Bioceramic and polycationic biopolymer nanocomposite scaffolds for improved wound self-healing and anti-inflammatory properties: an in vitro study | |
| Xu et al. | Investigation of magnetron sputtered nano-silver coating on titanium surface with micro-nanostructure | |
| Far et al. | Enhancing bone tissue engineering with calcium and strontium nanoparticles immobilized on HKUST-1 | |
| Xu et al. | Sr2+-dependent microstructure regulation of biodegradable Sr-doped hydroxyapatite microspheres with interconnected porosity for sustained drug delivery | |
| CN1140299C (en) | Composite hydrothermal synthesis process for preparing nanometer-level hydroxyl apatite biological painting | |
| Poovendran et al. | Amalgamation and characterization of porous hydroxyapatite bio ceramics at two various temperatures | |
| CN201551386U (en) | antimicrobial bone fixing screw | |
| KR20210000127A (en) | Hemostatic composition having improved mechanical strength and absorptiveness for effeecitve hemostasis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |