Summary of the invention: the object of the invention is to provide i.e. " skin the is quick " combination drug of the dermopathic medicine of a kind of treatment.
Medicine of the present invention is made (consumption is a weight portion) by following component:
Semen Nelumbinis 10-50 part Radix Sophorae Flavescentis 5-10 part Radix Salviae Miltiorrhizae 10-20 part Radix Saposhnikoviae 5-10 part
Cortex Dictamni 5-10 part Herba Portulacae 5-10 part Spina Gleditsiae 5-10 part Radix Glycyrrhizae 1-6 part
The formula optimization weight proportion scope of preparation medicine of the present invention is:
Semen Nelumbinis 15-25 part Radix Sophorae Flavescentis 6-8 part Radix Salviae Miltiorrhizae 10-15 part Radix Saposhnikoviae 6-8 part
Cortex Dictamni 6-8 part Herba Portulacae 6-8 part Spina Gleditsiae 6-8 part Radix Glycyrrhizae 3-5 part
The optimum weight proportioning of medicine of the present invention is:
8 parts of 15 parts of Radix Saposhnikoviaes of 8 parts of Radix Salviae Miltiorrhizaes of 20 parts of Radix Sophorae Flavescentiss of Semen Nelumbinis
4 parts of 8 parts of Radix Glycyrrhizae of 8 parts of Spina Gleditsiaes of 8 portions of Herba Portulacaes of Cortex Dictamni
The medicament that the present invention treats dermopathic medicine can be a said dosage form on any pharmaceutics, comprises decoction and capsule.
By " Chinese Clinical Chinese Materia Medica " (People's Health Publisher, 1998) described, the nature and flavor of all medicines, return through and effect be: Radix Sophorae Flavescentis, head is stated from Shennong's Herbal; The nature and flavor hardship, cold; Main large intestine, liver, the heart, the urinary bladder channel of returning; The tool heat clearing and damp drying, antipruritic, parasite killing diuresis, the effect of hemostasis and dysentery-stopping.Cortex Dictamni, head is stated from Shennong's Herbal; The nature and flavor hardship, cold; Main spleen, the stomach warp of returning; The tool heat-clearing and toxic substances removing, the effect of dampness removing to stop itchin (also tool dispel the wind merit).Radix Saposhnikoviae, head is stated from Shennong's Herbal, nature and flavor suffering, sweet, tepor; Main lung, spleen, the Liver Channel of returning; The tool expelling pathogenic wind from the body surface, removing dampness to relieve pain, antipruritic (dispelling wind for relieving itching), the effect of relieving convulsion.Semen Nelumbinis, head is stated from Shennong's Herbal; Nature and flavor are sweet, puckery, and are flat; Main spleen, kidney, heart channel of returning; The tool supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, leukorrhagia stopping, the effect that nourishes heart.Radix Salviae Miltiorrhizae, head is stated from Shennong's Herbal; The nature and flavor hardship is slightly cold; Main GUIXIN, pericardium, Liver Channel; The tool blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, the effect that relieving restlessness is calmed the nerves.
The preparation method of decoction of the present invention can adopt: take by weighing medicine by above-mentioned prescription, add the water logging bubble half an hour of 10 amounts for the first time, decocted 60 minutes, filter, each respectively decocted second and third time 30 minutes with 6 times of water gagings, merged medicinal liquid and got final product.
Also can adopt decoction and alcohol sedimentation technique: 8 flavor medicines are decocted 3 times, and the decocting with 10 times of amounts boiled 120 minutes for the first time, and twice each decocting with 6 times of amounts in back boiled 60 minutes, and last concentrated medicament becomes extractum; Add 95% ethanol again in extractum, concentration is transferred to 60%, placement is spent the night, and gets supernatant; Concentrated, dry, granulation, encapsulated.
Also can adopt the technology shown in the accompanying drawing 10 to prepare capsule.
Technological parameter wherein is:
Decocting boils: decoct number of times: 3 times;
Amount of water: 10 times of amounts for the first time, the twice 6 times of amounts in back;
Decocting time is respectively: 2hrs, 1hrs, 1hrs.
Clarification process: clarifier: ZTC1+1 clarifier;
Decocting liquid concentration: 1 kilogram of medical material: 2 liters of solution;
The clarifier consumption: A component water is made into 1% aqueous solution, and the B component is made into 1% with 1% acetic acid
Acetum adds the A component after adding the B component earlier.Clarifier A, B
With the optimal proportion of liquor capacity be 1: 2: 50.
Macroporous resin technology: resin model: D101
The present invention is based on following know-why and formulates out:
Full side is a monarch drug with Radix Sophorae Flavescentis, Cortex Dictamni, and medicines such as Radix Saposhnikoviae, Semen Nelumbinis, Radix Salviae Miltiorrhizae are minister, help, make it medicine.Radix Sophorae Flavescentis, the equal tool heat clearing away of Cortex Dictamni eliminating dampness by diuresis, the antipruritic merit of removing dampness are always for treating the product of the damp and hot pruritus first-selection of skin; Two medicines are played the antipruritic merit of heat clearing away eliminating dampness by diuresis altogether.Medicines such as Radix Saposhnikoviae, Semen Nelumbinis, Radix Salviae Miltiorrhizae are minister, help, make it medicine, principal drug assistance " the heat clearing away eliminating dampness by diuresis is antipruritic ", and the effect of playing " dispelling wind for relieving itching, removing the necrotic tissue and promoting granulation " altogether.Radix Saposhnikoviae also is the key medicine of traditional dispelling wind for relieving itching for the dispelling wind that induces sweat, the key medicine of dispeling the wind; Semen Nelumbinis are the key medicine of spleen channel, strengthening the spleen gas, support spleen the moon, and the body of anaphylaxis is had the pivot of regulating taste, the effect of strong the foundation of acquired constitution, and it can help the water fortuneization that wet, the power that wets with anatonosis; Gas the moon of its strengthening the spleen, longue meat can help impaired skin reparation.Radix Salviae Miltiorrhizae is the product of blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood, eliminating carbuncle, share with its medicine, can solve the difficulty of " blood is stopped up skin and decreased ", plays the effect of blood stasis dispersing and deswelling; The power that it is invigorated blood circulation, reason that can " the blood sector-style is gone out in vain " helps the monarch and his subjects' medicine " dispelling wind for relieving itching, heat clearing away eliminating dampness by diuresis, removing the necrotic tissue and promoting granulation ".In addition, the clear away heart-fire power of relieving restlessness of Plumula Nelumbinis tool is assisted mutually with the merit of Radix Salviae Miltiorrhizae relieving restlessness, also can solve the diseases such as dysphoria that the allergic skin patient causes because of diseases such as prurituss.
From modern medicine and pharmacology's principle, compare with the Western medicine of present treatment skin allergy or Chinese medicine and preparation thereof, the existing antiallergic of " skin is quick " compound recipe, blocking-up antigen antibody reaction, slow down or eliminate anaphylactoid effect, paid attention to again the treatment of skin lesion due to after the allergy and the medication of tissue repair aspect.This is we's characteristic place, also embodies the effect of Chinese medicine compound wholistic therapy, multipath, the adjusting of many target spots.
Full side is totally eight flavor plant medicine materials, experimental verifications such as pharmacodynamics test by clinical observation in early stage and full side, this side truly has the effect of " dispelling wind for relieving itching, heat clearing away eliminating dampness by diuresis, removing the necrotic tissue and promoting granulation ", has the blocking-up antigen antibody reaction, slow down or removes anaphylactoid anti-allergic effects and tissue repair effect, aspect skin allergic diseases such as treatment eczema, have definite curative effect and excellent development prospect.
Solution of the present invention is to combine with determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs from treatment based on differentiation of disease to start with, pathogenesis key at eczema in the anaphylaxis dermatosis " damp and hot " type it " ailment said due to cold or exposure is trouble, damp-heat accumulation, blood heap soil or fertilizer over and around the roots skin damage ", by " dispelling wind for relieving itching, heat clearing away eliminating dampness by diuresis, removing the necrotic tissue and promoting granulation ", synthesis treatment is to reach the effect of quick, the antiallergic of disappearing, reparation skin lesion.The present invention pays attention to the medication of skin lesion reparation aspect, with " removing the necrotic tissue and promoting granulation " in " dispelling wind for relieving itching, heat clearing away eliminating dampness by diuresis "; Thereby full side has the effect of " dispelling wind for relieving itching, heat clearing away eliminating dampness by diuresis, removing the necrotic tissue and promoting granulation ".
The present invention's " skin is quick " compound recipe is compared good effect and the advantage brought with similar Chinese medicine preparation: to allergy follow-up due to the reparation and the anti-tissue fibering effect of skin lesion remarkable, this is the characteristic and the advantage place of this side's treatment anaphylaxis dermatosis.According to market survey, to can efficient, long-acting antiallergic, and the market demand with endo-medicine of good promotion skin injury reparation increases day by day, and the market share enlarges year by year, and this market demand has been catered in the development of " skin is quick " compound recipe just.This compound recipe will for market provide one can antiallergic, can repair the new medicine endo-medicine of skin injury again.
The specific embodiment:
Below in conjunction with accompanying drawing, further specify essentiality content of the present invention with embodiments of the invention, but content of the present invention is not limited thereto.
Embodiment 1:
Take by weighing raw material by following proportioning:
Semen Nelumbinis 30 gram Radix Sophorae Flavescentiss 10 gram Radix Salviae Miltiorrhizaes 20 gram Radix Saposhnikoviaes 15 grams
Cortex Dictamni 10 KEMA bitterroots 10 gram Spina Gleditsiaes 10 gram Radix Glycyrrhizae 5 grams
Preparation method: take by weighing medicine by above-mentioned prescription, add the water logging bubble half an hour of 10 amounts for the first time, decocted 60 minutes, filter, each respectively decocted second and third time 30 minutes with 6 times of water gagings, merged medicinal liquid and got final product.
Embodiment 2:
Take by weighing raw material by following proportioning:
Semen Nelumbinis 40 gram Radix Sophorae Flavescentiss 15 gram Radix Salviae Miltiorrhizaes 30 gram Radix Saposhnikoviaes 15 grams
Cortex Dictamni 15 KEMA bitterroots 10 gram Spina Gleditsiaes 10 gram Radix Glycyrrhizae 8 grams
Adopt decoction and alcohol sedimentation technique: 8 flavor medicines are decocted 3 times, and the decocting with 10 times of amounts boiled 60 minutes for the first time, and twice each decocting with 6 times of amounts in back boiled 30 minutes, and last concentrated medicament becomes extractum; Add 95% ethanol again in extractum, concentration is transferred to 60%, placement is spent the night, and gets supernatant; Concentrated, dry, granulation, encapsulated.
Embodiment 3:
Take by weighing raw material by following proportioning:
Semen Nelumbinis 40 gram Radix Sophorae Flavescentiss 15 gram Radix Salviae Miltiorrhizaes 30 gram Radix Saposhnikoviaes 15 grams
Cortex Dictamni 10 KEMA bitterroots 10 gram Spina Gleditsiaes 10 gram Radix Glycyrrhizae 5 grams
Prepare capsule by the technology shown in the accompanying drawing 10 then.
Technological parameter is:
Decocting boils: decoct number of times: 3 times;
Amount of water: 10 times of amounts for the first time, the twice 6 times of amounts in back;
Decocting time is respectively: 2hrs, 1hrs, 1hrs.
Clarification process: clarifier: ZTC1+1 clarifier;
Decocting liquid concentration: 1 kilogram of medical material: 2 liters of solution;
The clarifier consumption: A component water is made into 1% aqueous solution, and the B component is made into 1% with 1% acetic acid
Acetum adds the A component after adding the B component earlier.Clarifier A, B
With the optimal proportion of liquor capacity be 1: 2: 50.
Macroporous resin technology: resin model: D101
Further specify essence of the present invention and excellent benefit with pharmacological toxicology result of study of the present invention and clinical test results below:
1 clinical research data
1.1 clinical case is collected overview
With reference to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of State Administration of Traditional Chinese Medicine's issue, according to the rule of treatment of " disease combination, medical treatment synchronously ", make the anaphylactic disease clinic diagnosis and observe table, be used to collect case, and carry out statistical analysis.
Between in March, 1999 to 2003 year December, altogether systematic collection the clinical case of 331 routine anaphylactic diseases, wherein anaphylaxis dermatosis 219 examples account for 66.13% of total case load.
In 219 routine skin allergy patients, male 97 examples, women 112 examples, man: woman=1: 1.2.The oldest 67 years old, minimum 2 years old.35 people below 10 years old account for 15.93%; 10-20 year 8 people account for 26.48%; 21-30 year 62 people account for 28.31%; 31-40 year 29 people account for 13.24%; 41-50 year 20 people account for 9.13%; 51-70 year 15 people account for 6.86%.Clinical practice " skin is quick " treatment 219 routine patients with allergic dermatosis, produce effects 175 examples, effective 37 examples, invalid 7 examples, total effective rate is 96.80%.
1.2 typical medical record for example
(1) Lee * *, man, 53 years old.Extremity are seriously irritated.Show as papulovesicle in blocks, be fused into lamellar lichen sample pathological changes, on cover white squama, skin is bronzing.Play is itched, owing to scratch, companion's cicatrix and blood crusts, are hide-like at pachyderma, drying, and skin lesion is serious.Go to a doctor in May, 2002, add flavor after 2 weeks of treatment with " skin is quick " compound recipe, symptom is obviously improved, and skin pruritus alleviates, pimple reduces, rash piece color obviously goes down.Continue 5 doses of clothes thicken that skin goes down, gargalesthesia disappears, and losing has the xerosis cutis desquamation, continue treatment January, and then skin lesion is repaired fully, grows new skin, and it is ruddy that skin color recovers, and all diseases disappear.
(2) week *, woman, 39 years old.General welt prurigo of skin is surplus March.From the beginning of being the welt sample infringement of differing in size, scorching hot pruritus, the rapid spread that continues is to whole body, and rash piece color is light, pruritus is hard to bear, and windburn increases the weight of whenever.Lasting a few hours disappear voluntarily, and outbreak every day for several times.In JIUYUE, 2002 is gone to a doctor, clothes with " skin is quick " 4 doses after, the prurigo attack times obviously reduces, rash piece scope also sees and dwindles that aversion to wind disappears, only two accidental several rash groups of forelimb.After continuing 3 weeks of treatment, the state of an illness is not more repeatedly.
(3) king *, man, 17 years old.Abnormal pigmentary deposit on the skin lamellar erythra appears in face and cervical region, settles in a foreign country or in another city many with forehead, cheeks.Color is red, and the part diabrosis has sepage, accompanies red and swollen desquamation, the time itch time pain, behind Exposure to Sunlight or ichthyophagy shrimp etc. more very.In JIUYUE, 2002 is gone to a doctor, with " skin is quick " compound treatment, obey 3 doses after, the red abnormal pigmentary deposit on the skin color of skin goes down, diabrosis face is restrained, gargalesthesia alleviates.Continue to take medicine after January, the facial area skin eruption disappears, and skin is as before bright and clean, and the ichthyophagy shrimp is not recurred, stable curative effect.
(4) Song * *, the woman, 35 years old, pimple and phlysis appearred in waist and belly, part is with pustule, red, the conscious pruritus of skin-color, that grabs has a sepage.Go to a doctor in November, 2003, after " skin is quick " 2 weeks of treatment, above symptom significantly alleviates, continue medication January after, be almost recovered.
Clinical observation shows that " skin is quick " compound recipe has the good curing effect to anaphylaxis dermatosis, diminishes inflammation reaction and itching-relieving action rapidly and obviously.In addition, " skin is quick " is particularly outstanding to the repair of skin histology damage.In the middle of its clinical most skin autopath who cures, the basic preventing from scar in back more, the non-pigment calmness, impaired skin intact as before.This with experimentation afterwards in have the discovery of good repairing effect consistent to animal (mice) skin injury due to the medicine irritation.This also is the advantage place of we's treatment anaphylaxis dermatosis.By clinical observation, confirmed the definite curative effect of " skin is quick " compound treatment skin allergy.
2 pharmacological toxicology testing datas
2.1 influence to mice passive cutaneous anaphylaxis, PCA of the same race (PCA)
The influence of table 1 pair mice passive cutaneous anaphylaxis, PCA of the same race (X ± SD)
Group n dosage (g/kg) absorbance (A) suppression ratio (%)
Blank 14 NS such as capacity such as grade 0.126 ± 0.025
Chlorphenamine 13 0.004 0.056 ± 0.016
*55.6
Routine dose 13 34 0.078 ± 0.014
*62.0
High dose 11 102 0.072 ± 0.018
*58.1
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
The result shows (see figure 1): " skin is quick " water decoction has the obvious suppression effect to mice passive cutaneous anaphylaxis, PCA of the same race.Two " skin is quick " group has the highly significant meaning with blank group comparing difference.
2.2 influence to mouse ear xenogenesis passive cutaneous anaphylaxis, PCA (PCA)
The influence of table 2 pair mouse ear xenogenesis passive cutaneous anaphylaxis, PCA (X ± SD)
Group n dosage (g/kg) absorbance (A) suppression ratio (%)
Blank 10 NS such as capacity such as grade 0.175 ± 0.052
Chlorphenamine 10 0.004 0.052 ± 0.015
*69.0
Routine dose 10 34 0.129 ± 0.016
*30.1
High dose 10 102 0.106 ± 0.014
*40.6
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
The result shows (see figure 2): passive cutaneous anaphylaxis, PCA has the obvious suppression effect to " skin is quick " water decoction two dosage groups to the mouse ear xenogenesis.Wherein the routine dose group has the significance meaning with blank group comparing difference, and high dose group has the highly significant meaning with blank group comparing difference.
2.3 to 2, the influence of 4-dinitrochlorobenzene (DNCB) induced mice delayed hypersensitivity (DTH)
The influence of table 3 pair DNCB induced mice delayed hypersensitivity (X ± SD)
Group n dosage (g/kg) ear swelling degree
Blank 16 NS such as capacity such as grade 4.058 ± 0.797
Prednisolone acetate 16 0.005 1.388 ± 0.712
*
Routine dose 16 34 2.822 ± 0.795
*
High dose 16 102 2.544 ± 1.275
*
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
The result shows (see figure 3): " skin is quick " water decoction can significantly suppress the mice delayed hypersensitivity that caused by DNCB.Two " skin is quick " group has the highly significant meaning with blank group comparing difference.
2.4 effect to dextran induced mice skin pruritus
The effect of table 4 pair dextran induced mice skin pruritus (X ± SD)
Group n dosage (g/kg) number of times of scratching where it itches is scratched where it itches the persistent period
Blank 12 NS such as capacity such as grade 31.7 ± 12.5 165.8 ± 48.3
Chlorphenamine 14 0.004 15.6 ± 8.5
*34.6 ± 19.9
*
Routine dose 12 34 19.9 ± 6.8
*60.1 ± 25.0
*
High dose 14 102 16.7 ± 5.4
*51.3 ± 18.6
*
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
The result shows (see figure 4): the number of times or scratch where it itches the persistent period of no matter scratching where it itches, each administration group and blank group relatively, except that the high dose group persistent period difference of scratching has the significance meaning, all the other respectively organize index all the highly significant meaning.
2.5 the effect that histamine induced mice capillary permeability is increased
The table 5 pair effect that histamine induced mice capillary permeability increases (X ± SD)
Group n dosage (g/kg) absorbance (A) suppression ratio (%)
Blank 16 NS such as capacity such as grade 0.496 ± 0.121
Chlorphenamine 15 0.004 0.130 ± 0.063
*73.8
Routine dose 14 34 0.213 ± 0.078
*57.0
High dose 14 102 0.255 ± 0.104
*48.6
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
The result shows (see figure 5): the capillary permeability due to the obvious antagonism histamine of " skin is quick " water decoction two dosage groups energy increases, and two " skin is quick " group has the highly significant meaning with the blank comparing difference of organizing.
2.6 the influence of xylol induced mice ear swelling
The influence of table 6 xylol induced mice ear swelling (X ± SD)
Group n dosage (g/kg) ear swelling degree
Blank 10 NS such as capacity such as grade 15.4 ± 1.54
Prednisolone acetate 10 0.005 8.2 ± 0.5
*
Routine dose 10 34 12.3 ± 2.37
*
High dose 10 102 10.1 ± 1.56
*
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
The result shows (see figure 6): " skin is quick " water decoction can obviously alleviate dimethylbenzene induced mice ear swelling degree, and two " skin is quick " group has the highly significant meaning with blank group comparing difference.
2.7 influence to rat cranial periosteum mast cell degranulation
The influence of table 7 pair rat cranial periosteum mast cell degranulation (X ± SD)
Group n dosage (g/kg) takes off granule rate (%) suppression ratio (%)
Blank 10 NS such as capacity such as grade 85.0 ± 4.5
Sodium cromoglicate 10 0.025 30.2 ± 6.4
*64.4
Routine dose 10 23.4 67.0 ± 7.6
*21.2
High dose 10 70.2 53.8 ± 8.8
*36.6
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
The result shows that (see figure 7) " skin is quick " water decoction two dosage groups take off granule to rat hypertrophy cell obvious inhibitory action is all arranged.Have and the highly significant meaning with blank group comparing difference.
2.8 determination experiment to the sensitized guinea pig SERUM IgE
The result shows (see figure 8): " skin is quick " water decoction two dosage groups and model control group compare, and difference has the significance meaning.Two " skin is quick " group can make the generation of the Immunoglobulin IgE of mediation I type allergy reduce.
The determination experiment of table 8 pair sensitized guinea pig SERUM IgE (X ± SD)
Group n dosage (g/kg) IgE value (iv/ml)
Blank 10 NS such as capacity such as grade 50.5 ± 4.3
Model contrasts 10 NS such as capacity such as grade 90.9 ± 12.9
*
Routine dose 10 20.15 68.4 ± 5.8
*
High dose 10 60.45 65.2 ± 8.9
*
Annotate: compare with the blank group,
*P<0.01,
*P<0.05.
2.9 acute toxicity test
Because the restriction of concentration and volume can't calculate LD50, so measure maximum dosage-feeding.
Get 40 of 18-22g mices, male and female half and half, be divided into 2 groups at random, water 12h is can't help in fasting before the test, the blank group gives with volume NS, and the administration group is irritated stomach " skin is quick " water decoction concentrated solution (132g/kg) 40ml/kg, and gastric infusion is three times in one day, each 4-5h at interval is equivalent to 110 times of clinical adult's consumption.Observed continuously then 7 days.Observe every day, relatively outward appearance, behavior and the toxic reaction of two groups of mices, the next day claim body weight one time.
Result: observe that each treated animal does not have death in 7 days, do not see obvious poisoning symptom, dissect and do not see that also internal organs have obvious pathological changes.Because of the acute toxicity test dosage is calculated as 110 times of clinical consumptions by 70kg adult body weight, so can think that " skin is quick " water decoction is safe.
2.10 other observed result in the experimentation
In the experiment of DNCB induced mice delayed hypersensitivity, each treated animal all gives DNCB sensitization, because DNCB has intense stimulus to skin, causes and respectively organizes the brown induration shape damage darkly of mouse web portion sensitization place skin.The skin lesion reparation phenomenon of finding routine dose group and high dose group mice in 7 days administration processes subsequently obviously is better than positive and blank group.The time of healing of two " skin is quick " administration group skin injury face and the growth of new flesh is shorter, and the reparation degree is better, and skin lesion position pigmentation alleviates, and color is progressively desalinated.Scleroma is softening, oozes out minimizing, and grows new skin gradually, and to administration last day, most of mice skin lesion is repaired substantially, grows new skin, and minority animal even skin are as excellent as before; The positive controls animal skin lesion that gives prednisolone acetate also has slow reparation, but reparation speed and degree are lower than " skin is quick " group.Mouse skin scleroma shape makes moderate progress, but the damage surface healing is slow, and the new flesh speed of growth is slower; The blank group mice that gives NS relies on self-ability to carry out the skin lesion reparation fully, and its speed and degree obviously are weaker than each administration group.The part animal is owing to the impaired skin of scratching, bite causes the traumatic infection diffusion.
Above observed result shows: " skin is quick " water decoction two dosage groups have the function that promotes the skin histology injury repairing.Verified that promptly we have the effect of " removing the necrotic tissue and promoting granulation " clinically.
By a series of experiments, prove that " skin is quick " has an efficacious prescriptions medicine for anti-skin allergy.Can act on anaphylactoid a plurality of link, comparing difference with the blank group has significance meaning or highly significant meaning, and has the skin lesion repairing effect.Thereby provide the empirical theory foundation of our curative effect.This and " skin is quick " compound recipe are applied to for many years clinical, and the treatment anaphylaxis dermatosis is obtained the conclusion of putting into practice of significantly producing effects and conformed to.
Show through clinical observation and experimental result, in treatment anaphylaxis dermatosis process, compare with similar Western medicine preparation, " skin is quick " is though compound recipe is only close with Western medicine aspect performance curative effect speed, but the effective persistent period in follow-up treatment is observed, skin lesion repair are obviously strong and Western medicine, and aspects such as toxic and side effects, recurrence rate after healing are lower than Western medicine.Particularly reparation and the anti-tissue fibering aspect to caused skin damage after the allergy demonstrated strong advantage.