CN1593355A - Non-homogeneous pharmaceutical elution supporting stand - Google Patents
Non-homogeneous pharmaceutical elution supporting stand Download PDFInfo
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- CN1593355A CN1593355A CN 200410043703 CN200410043703A CN1593355A CN 1593355 A CN1593355 A CN 1593355A CN 200410043703 CN200410043703 CN 200410043703 CN 200410043703 A CN200410043703 A CN 200410043703A CN 1593355 A CN1593355 A CN 1593355A
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- support
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Abstract
The disclosed non-homogeneous medicinal elution support bracket comprises a supporting frame, a carrier polymeric compound and medicinal member, wherein the support bracket is a meshwork formed by stainless steel tube through laser photoetching, the carrier polymeric compound and the medicinal member form a composition and adhere onto the surface of the meshwork, the adhesion amount of the medicinal member on one end of the support bracket and the intermediate section is less than that in unit length on the other end.
Description
Technical field:
The present invention relates to a kind of support that is used for human vas expansion stenosis blood vessel.
Background technology:
In the process of treatment blood vessel local stenosis, replaced simple balloon expandable method with the support expansion method gradually at present, made restenosis rate reduce to 20-30% by 40-50%.But support insert except thereby expansion lesion blood vessel guarantees to have competent blood and flow into the heart, also blood vessel is caused damage.Absorption of proteins and hematoblastic sticking and a series of biochemical reactions such as gatherings, initiation blood coagulation in various degree easily take place at this place in the serum.Moreover support inserts and makes blood vessel wall that acute and chronic inflammation take place, and brings out the various kinds of cell growth factor, make the middle level smooth muscle cell proliferation, migrate to tunica intima.Inflammation and outgrowth influencing each other are impelled vascellum endometrial hyperplasia, luminal stenosis, hinder blood flow.For fear of the appearance of above complication, radiant stand and various FirebirdTM arise.Especially bracket for eluting medicament its restenosis rate in selectable case has been reduced to below 10%, has opened up the new milestone of coronary heart disease interventional therapeutic technique.Radiant stand is based on ray and can kills proliferative cell and propose, but radiant stand edge restenosis is so-called edge effect (Edge effect) or candy paper effect (Candy effect) curative effect of this support is had a greatly reduced quality.Usually by flooding, spray or brush the polymer foil of one or more layers polymer, medicine or carrying medicaments, the polymer of wherein selecting for use has excellent biological compatibility on the surface of FirebirdTM, eliminates at support and inserts the foreign body reaction that the back occurs.This polymer is divided into two kinds of biodegradable and biological non-degradables, generally has suitable viscosity, high molecular weight, good adhesion, suitable elasticity, extensibility and can be dissolved in performances such as volatilizable organic solvent.The medicine that carries is including, but not limited to medicines such as anti-proliferative drug (resisting mitosis), anti-inflammatory drug, immunosuppressant.Bracket for eluting medicament is to realize with infiltration by the diffusion of medicine in lesion to the inhibitory action of vascellum endometrial hyperplasia, and this realization is influenced by the speed and the blood vessel concrete condition of blood flow in the blood vessel.As shown in Figure 1, near-end 2-1 at blood vessel (is that FirebirdTM 1 blood flows into the blood vessel in the 5mm scope of the end outside, the edge is narrow to mostly occur herein), since blood flow to relation, diffusion and the drug level that is penetrated into this place will be significantly less than the far-end 2-2 (blood vessel in the 5mm scope of the FirebirdTM 1 blood outflow end outside) of blood vessel, make medicine can not effectively cover the injury region of near-end blood vessel wall, this phenomenon is particularly remarkable at little blood vessel and long lesion, is similar to " edge effect " and " the geographical loss " of radiating support thereby bracket for eluting medicament has been produced.In order to alleviate edge effect, the amount of carrying that needs to increase medicine strengthens the especially drug level of near-end of edge.But whole increase dose makes that in drug release process the blood drug level value of overstepping the extreme limit can work the mischief to human body.
Summary of the invention:
In order to solve the problem that medicine on the existing FirebirdTM can not effectively cover near-end vascular damaged place, provide a kind of can be under the prerequisite that does not improve the medicine total amount, increase near the FirebirdTM of the drug level blood vessel wall of proximal end.The present invention realizes by following scheme: a kind of non-homogeneous bracket for eluting medicament, it is made up of support 1, carrier polymer and medicine body, support 1 is the net that stainless steel tube forms behind laser ablation, carrier polymer and medicine body form on compositions and the surface attached to the net of support 1, and the medicine body is at the adhesion amount of end 1-3 of support 1 and the interlude 1-2 place unit length adhesion amount less than other end 1-1 place unit length.When support 1 of the present invention was inserted in the human vas 2, the end that the medicine body burden is big was arranged on the near-end of blood vessel, and to dissolve the medicine scale of construction that discharges just many for the end that the medicine body burden is big like this, and the time that discharges medicine is also long.Thereby avoided the insufficient phenomenon of the effective overlay capacity of near-end vascular damaged place medicine.Because the heterogeneity that FirebirdTM medicine of the present invention adheres to, making is not increasing medicine body total amount, do not damage under the prerequisite of health, solved " edge effect " and problems such as " geographical lose ", have reasonable in design, reliable operation and be suitable for advantage such as popularization.
Description of drawings:
Fig. 1 is that the present invention is arranged on the structural representation in the blood vessel 2.
The specific embodiment:
The specific embodiment one: specify present embodiment below in conjunction with Fig. 1.The FirebirdTM of present embodiment is made up of support 1, carrier polymer and medicine body, support 1 is the net that stainless steel tube forms behind laser ablation, carrier polymer and medicine body form on compositions and the surface attached to the net of support 1, and the medicine body is at the adhesion amount of end 1-3 of support 1 and the interlude 1-2 place unit length adhesion amount less than other end 1-1 place unit length.
Present embodiment realizes by following method: one, support 1 is fixed on the miniature anchor clamps.Two, carry out applying the first time.Specifically be support 1 one ends to be immersed include in the solution of carrier polymer and medicine body.For guaranteeing the uniformity of coating, keep support 1 in solution, to move.Three, taking-up back placement a period of time is fallen solvent evaporates.Four, fix an end,, carry out applying the second time simultaneously according to the length of support.Secondary applies and to comprise an end is carried out or two ends are applied respectively.Five,, can carry out the coating of more times number for to make the end form different drug level gradients.
The specific embodiment two: the difference of present embodiment and embodiment one is that carrier polymer comprises polyurethane, silicone, polyacrylate, polyester or polyvinyl alcohol and copolymer separately, aliphatic polyester, polyamino acid or polyamine and copolymer separately thereof.The long-acting uniform dissolution of its messenger drug object discharges.The medicine body comprises medicines such as anti-proliferative drug, anti-inflammatory drug or immunosuppressant.Clinical research at present finds that outstanding effect is rapamycin or paclitaxel.
The specific embodiment three: the difference of present embodiment and embodiment one is that the adhesion amount of support 1 interlude 1-2 place unit length medicine body is less than the medicine body adhesion amount of support 1 one end 1-3 place unit lengths.So be provided with, also useful to blood vessel far-end 2-2 injury region.
The specific embodiment four: the difference of present embodiment and embodiment one is that at support 1 one end 1-3 and interlude 1-2 place, the concentration content of medicine body in compositions is less than the concentration content at the other end 1-1 place of support 1.Present embodiment can realize by changing polymer support and medicine liquid solution proportioning.
Claims (6)
1, a kind of non-homogeneous bracket for eluting medicament, it is made up of support (1), carrier polymer and medicine body, support (1) is the net that stainless steel tube forms behind laser ablation, carrier polymer and medicine body form on compositions and the surface attached to the net of support (1), it is characterized in that adhesion amount that the medicine body is located unit length at an end (1-3) and the interlude (1-2) of support (1) locates the adhesion amount of unit length less than the other end (1-1).
2, non-homogeneous bracket for eluting medicament according to claim 1 is characterized in that carrier polymer comprises polyurethane, silicone, polyacrylate, polyester or polyvinyl alcohol and copolymer separately, aliphatic polyester, polyamino acid or polyamine and copolymer separately thereof.
3, non-homogeneous bracket for eluting medicament according to claim 1 is characterized in that the medicine body comprises anti-proliferative drug, anti-inflammatory drug or immune suppressant drug.
4,, it is characterized in that the medicine body is rapamycin or paclitaxel according to claim 1 or 3 described non-homogeneous bracket for eluting medicament.
5, non-homogeneous bracket for eluting medicament according to claim 1 is characterized in that support (1) interlude (1-2) locates the adhesion amount of unit length medicine body is located unit length less than support (1) one end (1-3) medicine body adhesion amount.
6, non-homogeneous bracket for eluting medicament according to claim 1 is characterized in that locating the concentration content that the concentration content of medicine body in compositions is located less than the other end (1-1) of support (1) at support (1) one end (1-3) and interlude (1-2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410043703 CN1593355A (en) | 2004-07-12 | 2004-07-12 | Non-homogeneous pharmaceutical elution supporting stand |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410043703 CN1593355A (en) | 2004-07-12 | 2004-07-12 | Non-homogeneous pharmaceutical elution supporting stand |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1593355A true CN1593355A (en) | 2005-03-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410043703 Pending CN1593355A (en) | 2004-07-12 | 2004-07-12 | Non-homogeneous pharmaceutical elution supporting stand |
Country Status (1)
| Country | Link |
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| CN (1) | CN1593355A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011079806A1 (en) * | 2009-12-30 | 2011-07-07 | 微创医疗器械(上海)有限公司 | Self-expanding stent |
| CN107670163A (en) * | 2017-11-02 | 2018-02-09 | 乐普（北京）医疗器械股份有限公司 | A kind of medicine balloon dilating catheter and its preparation method and application |
| CN110831550A (en) * | 2017-07-07 | 2020-02-21 | 株式会社钟化 | Tubular medical instrument and tubular medical instrument transport device |
-
2004
- 2004-07-12 CN CN 200410043703 patent/CN1593355A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011079806A1 (en) * | 2009-12-30 | 2011-07-07 | 微创医疗器械(上海)有限公司 | Self-expanding stent |
| CN110831550A (en) * | 2017-07-07 | 2020-02-21 | 株式会社钟化 | Tubular medical instrument and tubular medical instrument transport device |
| CN110831550B (en) * | 2017-07-07 | 2021-10-22 | 株式会社钟化 | Tubular medical instrument and tubular medical instrument transport device |
| CN107670163A (en) * | 2017-11-02 | 2018-02-09 | 乐普（北京）医疗器械股份有限公司 | A kind of medicine balloon dilating catheter and its preparation method and application |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |