CN1582944A - Chlorophillni copper and sodium drops and their preparation - Google Patents
Chlorophillni copper and sodium drops and their preparation Download PDFInfo
- Publication number
- CN1582944A CN1582944A CN 200410044293 CN200410044293A CN1582944A CN 1582944 A CN1582944 A CN 1582944A CN 200410044293 CN200410044293 CN 200410044293 CN 200410044293 A CN200410044293 A CN 200410044293A CN 1582944 A CN1582944 A CN 1582944A
- Authority
- CN
- China
- Prior art keywords
- sodium
- chlorophyll
- preparation
- coolant
- copper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
A dripping pill of chlorophyll copper sodium is prepared by superfine pulverizing and conventional process for preparing dripping pills.
Description
Technical field
The present invention relates to a kind of pharmaceutical product and preparation method thereof, specifically copper chlorophyll sodium dropping balls and preparation method thereof.
Background technology
Chlorophyll copper sodium (Chlorophyllin Cupper Complex Sodium) is the chlorophyll that extracts from Bombyx mori L., chlorophyll copper sodium that obtains through saponification, copperization and the mixture of phyllins, be the hematopoietic cell complexing agent, the mechanism of chlorophyll leukocyte increasing mainly is by orthosympathetic irritability, and in the presence of adrenal gland's function, neutrophil cell is discharged from bone marrow at liver, its hematosis is because the porphyrin ring that chlorophyllous basic structure system is made up of four pyrrole rings is extremely similar to the structure of hemoglobin, so can impel hematosis.
Zoopery confirms that chlorophyll not only can promote because of irradiation causes an index such as erythrocyte in the Induced Aplastic Anemia Mice surrounding hemogram, hemoglobin, blood red born of the same parents, platelet, and the recovery of pluripotent stem cell in the mouse bone marrow cells (CFU-S), grain-single CFU-GM (CFU-GU), CFU-E (CFU-E) and marrow stromal cell is had obvious facilitation; Recovery to marrow stromal cell also has certain regulating action, so think that chlorophyll copper sodium is the adjusting of growing by to hematopoietic pluripotential stem cell, grain-single CFU-GM, CFU-E and marrow stromal cell propagation to the effect of hemopoietic, the recovery of hemopoietic.The clinical research result shows that chlorophyll copper sodium has the effect of compose living to the liver reticuloendothelial cell, and liver function is restored, and the enhance hepatocyte resistance is quickened to repair and regeneration, the enlargement liver is obviously dwindled or disappears.The tablet or the clinical auxiliary treatment and the leukopenia that is used for acute, chronic hepatitis of capsule of present listing.
Chlorophyll copper sodium has the special stink of similar aminated compounds, and hygroscopicity is arranged, and is easily molten in water, and aqueous solution is alkalescence.But its tablet or capsule disintegration time are long, and dissolution and dissolution rate are low, absorption difference, bioavailability is low, and the supplementary product consumption ratio is big, and child, old people, bed patient and dysphagia patients are taken inconvenience, compliance is poor, has influenced the performance of chlorophyll copper sodium therapeutical effect.
The present invention makes the chlorophyll copper sodium drop pill by using ultramicro communication technique and dropping pill formulation Technology exactly, thereby overcomes chlorophyll copper sodium tablet and capsular above defective, and the therapeutical effect of chlorophyll copper sodium is given full play to.
Summary of the invention
The copper chlorophyll sodium dropping balls of making by using ultramicro communication technique and dropping pill formulation Technology not only have disintegrate molten loose fast, dissolution and dissolution rate improve, steady quality, the pill volume is little, easy to carry and use, onset is rapid, compliance is good, be particularly suitable for the characteristics that child, old people, bed patient and dysphagia patients are taken, but also has working condition and production equipment is simple, production cost is low, compares the advantage that supplementary product consumption reduces with capsule with tablet, has demonstrated fully the new drug research exploitation spirit that people-oriented.
For achieving the above object, the present invention by the following technical solutions: the chlorophyll copper sodium fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, abundant mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
The molecular formula of chlorophyll copper sodium Chlorophyllin Cupper Complex Sodium is C among the present invention
34H
31O
6N
4CuNa
3, molecular weight is 724.16.
Substrate among the present invention includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
Coolant among the present invention includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Below through detecting to beneficial effect of the present invention as directed
One, detects index and method
1. disintegrate (molten loosing) time limit: check according to inspection technique disintegration (two appendix XA of Chinese Pharmacopoeia version in 2000).
2. dissolution rate: lucifuge operation.Sample thief, according to dissolution method (two appendix XC first methods of Chinese Pharmacopoeia version in 2000), phosphate solution with pH7.5 [is got 0.15mol/L disodium phosphate soln-0.15mol/L potassium dihydrogen phosphate (21: 4) mixing, promptly] 900ml is a solvent, rotating speed is that per minute 100 changes, operation in accordance with the law.In the time of 10,20,30,40 minutes, get solution 10ml, filter, get subsequent filtrate, according to spectrophotography (two appendix IVA of Chinese Pharmacopoeia version in 2000), be blank with the phosphate solution, at the wavelength place of 405nm, with C
34H
31O
6N
4CuNa
3Absorptance (E
1cm 1%) be 565 calculating stripping quantities.
Two, commercially available chlorophyll copper sodium tablet testing result
1. disintegration time: 34 minutes
2. dissolution rate:
Time (minute) 10 20 30 40
Dissolution (%) 51.6 73.6 92.3 94.5
Three, example 1 sample detection result
1. the molten diffusing time: 2 minutes
2. dissolution rate:
Time (minute) 10 20 30 40
Dissolution (%) 78.7 99.7 99.2 101.6
Four, example 2 sample detection results
1. the molten diffusing time: 2 minutes
2. dissolution rate:
Time (minute) 10 20 30 40
Dissolution (%) 74.5 98.4 99.6 99.9
Five, example 3 sample detection results
1. the molten diffusing time: 2 minutes
2. dissolution rate:
Time (minute) 10 20 30 40
Dissolution (%) 69.4 96.7 98.9 99.2
Six, example 4 sample detection results
1. the molten diffusing time: 3 minutes
2. dissolution rate:
Time (minute) 10 20 30 40
Dissolution (%) 74.5 98.7 99.0 98.0
Seven, example 5 sample detection results
1. the molten diffusing time: 4 minutes
2. dissolution rate:
Time (minute) 10 20 30 40
Dissolution (%) 76.5 99.2 98.9 97.5
Eight, example 6 sample detection results
1. the molten diffusing time: 5 minutes
2. dissolution rate
Time (minute) 10 20 30 40
Dissolution (%) 63.4 92.3 97.5 98.6
The specific embodiment
One, example 1
Prescription:
Chlorophyll copper sodium 5g
Polyethylene glycol 6000 15g
Make 1000
Method for making: the chlorophyll copper sodium fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused polyethylene glycol 6000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Two, example 2
Prescription:
Chlorophyll copper sodium 5g
Macrogol 4000 15g
Make 1000
Method for making: the chlorophyll copper sodium fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused Macrogol 4000 substrate, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Three, example 3
Prescription:
Chlorophyll copper sodium 5g
Polyethylene glycol 6000 10g
Macrogol 4000 5g
Make 1000
Method for making: the chlorophyll copper sodium fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused Macrogol 4000 and the polyethylene glycol 6000 mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Four, example 4
Prescription:
Chlorophyll copper sodium 5g
Glyceryl monostearate 15g
Make 1000
Method for making: the chlorophyll copper sodium fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in the fused glyceryl monostearate substrate, and mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Five, example 5
Prescription:
Chlorophyll copper sodium 5g
Polyethylene glycol 6000 10g
Poloxamer 5g
Make 1000
Method for making: the chlorophyll copper sodium fine powder that the micronizing of learning from else's experience is crossed 200 mesh sieves is added in fused polyethylene glycol 6000 and the poloxamer mixed-matrix, stirs evenly, and with the dimethicone coolant, the dropping preparation method pill, drying, promptly.
Six, example 6
Prescription:
Chlorophyll copper sodium 5g
Glyceryl monostearate 15g
Poloxamer 1g
Make 1000
Method for making: get the mixing fine powders that chlorophyll copper sodium and poloxamer cross 200 mesh sieves through micronizing and be added in the fused glyceryl monostearate substrate, mixing is a coolant with the frozen water, the dropping preparation method pill, and drying, promptly.
Claims (4)
1. copper chlorophyll sodium dropping balls and preparation method thereof is characterized in that: the chlorophyll copper sodium fine powder of 1 weight portion through micronizing is added in 1～10 weight portion molten matrix, fully mixing, dropping preparation method is condensed into ball in coolant, remove coolant, drying, promptly.
2. the molecular formula of the described chlorophyll copper sodium Chlorophyllin of claim 1 Cupper Complex Sodium is C
34H
31O
6N
4CuNa
3, molecular weight is 724.16.
3. the described substrate of claim 1 includes but not limited to polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc.
4. the described coolant of claim 1 includes but not limited to dimethicone, liquid paraffin, vegetable oil, water, alcoholic solution etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410044293 CN1582944A (en) | 2004-05-21 | 2004-05-21 | Chlorophillni copper and sodium drops and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410044293 CN1582944A (en) | 2004-05-21 | 2004-05-21 | Chlorophillni copper and sodium drops and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1582944A true CN1582944A (en) | 2005-02-23 |
Family
ID=34601733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410044293 Pending CN1582944A (en) | 2004-05-21 | 2004-05-21 | Chlorophillni copper and sodium drops and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1582944A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462671A (en) * | 2010-11-18 | 2012-05-23 | 何国增 | Preparation method of sodium copper chlorophyllin capsule |
| CN105147673A (en) * | 2015-10-12 | 2015-12-16 | 成都通德药业有限公司 | New application of sodium copper chlorophyllin to preparation of medicines for treating liver disease |
-
2004
- 2004-05-21 CN CN 200410044293 patent/CN1582944A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462671A (en) * | 2010-11-18 | 2012-05-23 | 何国增 | Preparation method of sodium copper chlorophyllin capsule |
| CN105147673A (en) * | 2015-10-12 | 2015-12-16 | 成都通德药业有限公司 | New application of sodium copper chlorophyllin to preparation of medicines for treating liver disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1582944A (en) | Chlorophillni copper and sodium drops and their preparation | |
| CN1490001A (en) | Hepadestal drops and preparation thereof | |
| CN1528321A (en) | Rhizoma gastrodiae extract drop pill and preparing method thereof | |
| CN1528287A (en) | Herba lysionoti extract drop pill and preparing method thereof | |
| CN1493280A (en) | Mezereum drip pill and its preparation method | |
| CN1562001A (en) | Carbazochrome sodium sulfoate dripping pill and its preparing method | |
| CN1528298A (en) | Isocarboxazid drop pill and preparing method thereof | |
| CN1582908A (en) | Tramadol hydrochloride drops and their preparation | |
| CN1602860A (en) | Dripping pills of clemastine fumarate and its preparation method | |
| CN1602848A (en) | Ambroxol hydrochloride drop pills and its preparation method | |
| CN1526393A (en) | Hydralazine hydrochloride guttate pills and the prepn | |
| CN1582943A (en) | Clomipramine hydrochloride drops and their preparation | |
| CN1493288A (en) | Hanfangchin A drip pill and its preparation method | |
| CN1526385A (en) | Ditropan hydrochloride dripping pills and the prepn process | |
| CN1546022A (en) | Dripping pills of luteanine hydrochloride and its preparation | |
| CN1582937A (en) | Amiloride hydrochloride drops and their preparation | |
| CN1528301A (en) | Nicorandic drop pill and preparing method thereof | |
| CN1493290A (en) | Ferulaic acid piperazine drip pill and its preparation method | |
| CN1528272A (en) | Agrimophol drop pill and preparing method thereof | |
| CN1602868A (en) | Dripping pills of ketotifen fumarate and its preparation method | |
| CN1528318A (en) | Herba adonidis aglycone drop pill and preparing method thereof | |
| CN1493274A (en) | Vanillic aldehyde drip pill and its preparation method | |
| CN1528281A (en) | Rhododeudron molle toxin drop pill and preparing method thereof | |
| CN1490005A (en) | Berberine or berberine salts drops and their preparation | |
| CN1493287A (en) | Shishan alkaloid drip pill and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |