CN1569056A - Chinese traditional medicine capable of warming kidney and invigorating yang - Google Patents
Chinese traditional medicine capable of warming kidney and invigorating yang Download PDFInfo
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- CN1569056A CN1569056A CNA031325084A CN03132508A CN1569056A CN 1569056 A CN1569056 A CN 1569056A CN A031325084 A CNA031325084 A CN A031325084A CN 03132508 A CN03132508 A CN 03132508A CN 1569056 A CN1569056 A CN 1569056A
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- salviae miltiorrhizae
- chinese medicine
- cornu cervi
- cervi pantotrichum
- allii tuberosi
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Abstract
The invention provides a Chinese traditional medicine capable of warming kidney and invigorating yang, which comprises gen-seng, root of red rooted saliva, hairy deerhorn, wolferry fruit, epimeddium, leek seeds, cnidium fruit.
Description
Technical field: the present invention relates to Chinese medicine, particularly have the Chinese medicine of warming the kidney to activate YANG function.
Background technology: be used for the treatment of soreness of the waist and knees at present, aversion to cold and cold limbs, the Chinese medicine of diseases such as impotence and premature ejaculation is of a great variety, but curative effect is all undesirable.
The content of invention: overcome the deficiency that prior art exists, propose a kind ofly can effect a radical cure soreness of the waist and knees, aversion to cold and cold limbs, the Chinese medicine with warming the kidney to activate YANG function of diseases such as impotence and premature ejaculation.This Chinese medicine is made of following composition: Radix Ginseng, Radix Salviae Miltiorrhizae, Cornu Cervi Pantotrichum, Fructus Lycii, Herba Epimedii, Semen Allii Tuberosi, Fructus Cnidii, the weight proportion of its composition is Radix Ginseng 580-620 part, Radix Salviae Miltiorrhizae 280--320 part, Cornu Cervi Pantotrichum 45--55 part, Fructus Lycii 1800--2200 part, sheep leaves of pulse plants 1800--2200 part, Semen Allii Tuberosi 550--650 part, Fructus Cnidii 280--320 part, more than seven the flavor, the five tastes such as Radix Ginseng, Radix Salviae Miltiorrhizae, Cornu Cervi Pantotrichum, Semen Allii Tuberosi, Fructus Cnidii sprayed 75% ethanol respectively airtight 1 hour, fling to the ethanol oven dry, be ground into coarse powder; Fructus Lycii, Herba Epimedii decoct with water three times, add 10 times of amounts at every turn, decoct 2 hours, filter, merging filtrate, being concentrated into relative density is the clear paste of 1.35 (80 ℃), adds Radix Salviae Miltiorrhizae, Semen Allii Tuberosi, Fructus Cnidii coarse powder mixing, dry, be ground into coarse powder, again with Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum mixing, packing, make 1000 bags, promptly.Radix Ginseng: sweet, little hardship, tepor.Strongly invigorating primordial QI, invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Chinese medicine of the present invention is owing to contain Radix Salviae Miltiorrhizae, and is bitter, be slightly cold, can promoting blood flow to regulate menstruation, and the removing heat from blood eliminating carbuncle is calmed the nerves.Contain Cornu Cervi Pantotrichum, sweet, salty, warm, the energy invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening is transferred to dash and is appointed, the holder sore.Contain Fructus Lycii, sweet, flat, have invigorating the liver and kidney, the effect that makes eye bright.Contain Herba Epimedii, hot, sweet, warm, have warming the kidney to invigorate YANG, bone and muscle strengthening, wind-damp dispelling effect.Contain Semen Allii Tuberosi, hot, sweet, warm, have the temperature compensation Liver and kidney, the effect of tonifying YANG controlling nocturnal emission with astringent drugs.Contain Fructus Cnidii, hot, bitter, warm, have killing parasites for relieving itching, the effect of warming the kidney to invigorate YANG.The result of above-mentioned every medicine comprehensive function makes Chinese medicine of the present invention have the function of warming the kidney to activate YANG.
The specific embodiment: get Radix Ginseng 600g, Radix Salviae Miltiorrhizae 300g, Cornu Cervi Pantotrichum 50g, Fructus Lycii 2000g, Herba Epimedii 2000g, Semen Allii Tuberosi 600g, Fructus Cnidii 280g, more than seven the flavor, the five tastes such as Radix Ginseng, Radix Salviae Miltiorrhizae, Cornu Cervi Pantotrichum, Semen Allii Tuberosi, Fructus Cnidii sprayed 75% ethanol respectively airtight 1 hour, fling to the ethanol oven dry, be ground into coarse powder; Fructus Lycii, Herba Epimedii decoct with water three times, add 10 times of amounts at every turn, decoct 2 hours, filter, merging filtrate, being concentrated into relative density is the clear paste of 1.35 (80 ℃), adds Radix Salviae Miltiorrhizae, Semen Allii Tuberosi, Fructus Cnidii coarse powder mixing, dry, be ground into coarse powder, again with Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum mixing, packing, make 1000 bags, promptly.
Second kind of embodiment of the present invention got Radix Ginseng 580g, Radix Salviae Miltiorrhizae 280g, Cornu Cervi Pantotrichum 45g, Fructus Lycii 1800g, sheep leaves of pulse plants 1800g, Semen Allii Tuberosi 550g, Fructus Cnidii 320g, and its processing method is with embodiment 1.
Instructions of taking: boiled water is taken after being infused in hot water or decoction, a 4g, 2 times on the one.
The hyperactivity of fire caused by deficiency of YIN person avoids usefulness.Every packed 4g.Airtight, put shady and cool dry place.
This product content is a dark-brown, is mingled with flaxen granule, mildly bitter flavor.
Differentiate
(1) ether extracted liquid of getting under [assay] item volatilizes, and residue adds ethyl acetate 2ml makes dissolving, as need testing solution.Other gets the tanshinone reference substance, adds ethyl acetate and makes the solution that every 1ml contains 0.5mg, in contrast product solution.According to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000) test, draw need testing solution 10 μ l, reference substance solution 4 μ l, put respectively on same silica gel g thin-layer plate, be developing solvent with benzene-ethyl acetate (19: 1), launch, take out, dry.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show identical pink speckle.
(2) get the need testing solution under [assay] item, as need testing solution.Other gets the icariin reference substance and adds methanol and make the solution that every 1ml contains 0.5mg, in contrast product solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, (15: 40: 22: 10) lower floor's solution of placing below 10 ℃ was developing solvent, launched, and took out with chloroform-ethyl acetate-methanol-water, dry, spray is with 10% ethanol solution of sulfuric acid, puts to dry by the fire to the speckle colour developing clearly under 100 ℃, inspects under fluorescent light.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Assay is got this product content 8g, and accurate the title decides, and puts in the apparatus,Soxhlet's, it is an amount of to add diethyl ether, and the water-bath reflux, extract, discards ether solution to colourless, the taking-up filtration paper cylinder dries, treat that ether waves to the greatest extent, filtration paper cylinder is placed apparatus,Soxhlet's again, it is an amount of to add methanol, placement is spent the night, putting in the water-bath refluxes, and to be extracted into methanol colourless, reclaims methanol to doing, and residue adds water 30ml makes dissolving, place separatory funnel, with water saturated n-butanol extraction 5 times (25,20,20,10,10ml), merge extractive liquid, is with ammonia solution washing 3 times, each 25ml, discard ammonia solution, with the n-butanol extracting liquid evaporate to dryness, residue adds methanol makes dissolving, quantitatively be transferred in the 5ml volumetric flask, and be diluted to scale, shake up, as need testing solution.Other gets the ginsenoside Rg
1Reference substance adds methanol and makes the solution that every 1ml contains 0.6mg, in contrast product solution.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw need testing solution 8 μ l, reference substance solution 2 μ l and 4 μ l, the cross point is on same silica gel g thin-layer plate respectively, lower floor's solution with chloroform-methanol-water (65: 35: 10) (place below 10 ℃ and spend the night) is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, about 5~7 minutes of 100 ℃ of bakings, clear to the speckle colour developing, take out, on lamellae, cover, use immobilization with adhesive tape on every side with onesize glass plate, scan according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B thin layer chromatography scanning), wavelength: λ s=535nm, λ R=700nm measures test sample trap integrated value and reference substance trap integrated value, calculate, promptly.
The every 1g of this product contains the ginsenoside Rg
1(C
42H
72O
14) should be no less than 0.13mg.
Estimate the clinical medicine safety of Chinese medicine of the present invention, it carried out toxicity test research, be reported as follows:
1. be subjected to test product: a kind of Chinese medicine every day with warming the kidney to activate YANG function 2 times, each 4 grams.
2. experimental animal: the white mice of Kunming kind, body weight 18-22 gram, male and female dual-purpose.
3. the preparation of dosage and test drug: get a kind of 4 grams of Chinese medicine with warming the kidney to activate YANG function, put and add the 10.0ml distilled water in the mortar and be uniformly dispersed, make solution.Administering mode is a gastric infusion.
The mensuration of median lethal dose(LD 50)
Get 9 of mices, divide three groups, but fail to find out the dosage of 100% animal dead.
Select 50 of the healthy mices of body weight 20 ± 2g for use, male and female half and half are divided into five groups at random, an oral administration gavage administration, and dosage is by geometric progression, and maximum dose level calculates with the maximum volume that can accept.Observed 7 days none death as a result after the administration.
Mtd test
Select 20 of healthy mices, male and female half and half, normally raise 1 after, administration is 2 times in 24 hours, observes continuously 7 12 hours blanking times, does not see untoward reaction and death condition, can think the oral avirulence of this medicine.
The maximum tolerated dose multiple is calculated as follows:
Calculate if obey 4 grams every day by the adult, the result is 240 times of normal clinical dosage, illustrates that the Chinese medicine with warming the kidney to activate YANG function has safety.
A kind of Chinese medicine clinical summary with warming the kidney to activate YANG function
One group to soreness of the waist and knees, aversion to cold and cold limbs, the statistics in the patients clinical observations of diseases such as impotence and premature ejaculation.
This organizes 5% case for observing the patient of treatment.Man's 43 examples wherein, women 16 examples, age 40-50 year 10 examples, 51-60 year 30 examples, 19 examples more than 61 years old, wherein Therapeutic Method is the patient to be divided into two groups at random, 39 examples are organized in treatment, obey Chinese medicine of the present invention, every day twice, each 4 grams, 60 days is a course of treatment.Matched group 20 examples are taken other medicine, and 60 days is a course of treatment, withdraws other medicines before the administration, all do inspection before and after the treatment, and the result shows that the treatment group effective percentage of taking Chinese medicine of the present invention is 98%, and matched group does not have obvious effects.
Claims (2)
1, a kind of Chinese medicine with warming the kidney to activate YANG function, it is characterized in that this Chinese medicine is made of following composition: Radix Ginseng, Radix Salviae Miltiorrhizae, Cornu Cervi Pantotrichum, Fructus Lycii, Herba Epimedii, Semen Allii Tuberosi, Fructus Cnidii, the weight proportion of its composition are Radix Ginseng 580--620 part, Radix Salviae Miltiorrhizae 280--320 part, Cornu Cervi Pantotrichum 45--55 part, Fructus Lycii 1800--2200 part, sheep leaves of pulse plants 1800--2200 part, Semen Allii Tuberosi 550--650 part, Fructus Cnidii 280--320 part.
2, the Chinese medicine with warming the kidney to activate YANG function as claimed in claim 1 is characterized in that its production technology is: the five tastes such as Radix Ginseng, Radix Salviae Miltiorrhizae, Cornu Cervi Pantotrichum, Semen Allii Tuberosi, Fructus Cnidii were sprayed 75% ethanol respectively airtight 1 hour, fling to the ethanol oven dry, be ground into coarse powder; Fructus Lycii, Herba Epimedii decoct with water three times, add 10 times of amounts at every turn, decoct 2 hours, filter, merging filtrate, being concentrated into relative density is the clear paste of 1.35 (80 ℃), adds Radix Salviae Miltiorrhizae, Semen Allii Tuberosi, Fructus Cnidii coarse powder mixing, dry, be ground into coarse powder, again with Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum mixing, packing, make 1000 bags, promptly.
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CNB031325084A CN1282477C (en) | 2003-07-17 | 2003-07-17 | Chinese traditional medicine capable of warming kidney and invigorating yang |
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CNB031325084A CN1282477C (en) | 2003-07-17 | 2003-07-17 | Chinese traditional medicine capable of warming kidney and invigorating yang |
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CN1569056A true CN1569056A (en) | 2005-01-26 |
CN1282477C CN1282477C (en) | 2006-11-01 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103651951A (en) * | 2013-11-22 | 2014-03-26 | 安徽大平油脂有限公司 | Health-care oil capable of warming kidney and tonifying yang and containing fructus cnidii |
CN104288461A (en) * | 2014-10-15 | 2015-01-21 | 浙江磐谷药源有限公司万泰元茶号 | Ginseng cornu cervi tea traditional Chinese medicine decoction piece combined preparation, as well as preparation method and combined package thereof |
CN111012861A (en) * | 2019-12-24 | 2020-04-17 | 哈药集团三精制药有限公司 | Preparation method for producing Qirong yang-invigorating oral liquid |
CN114652775A (en) * | 2020-12-22 | 2022-06-24 | 蛮力蛮(广州)医药科技有限公司 | External traditional Chinese medicine composition for nourishing penis |
-
2003
- 2003-07-17 CN CNB031325084A patent/CN1282477C/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103651951A (en) * | 2013-11-22 | 2014-03-26 | 安徽大平油脂有限公司 | Health-care oil capable of warming kidney and tonifying yang and containing fructus cnidii |
CN103651951B (en) * | 2013-11-22 | 2016-03-23 | 安徽大平油脂有限公司 | A kind of warming kidney to reinforce yang health-care oil containing frutus cnidii |
CN104288461A (en) * | 2014-10-15 | 2015-01-21 | 浙江磐谷药源有限公司万泰元茶号 | Ginseng cornu cervi tea traditional Chinese medicine decoction piece combined preparation, as well as preparation method and combined package thereof |
CN111012861A (en) * | 2019-12-24 | 2020-04-17 | 哈药集团三精制药有限公司 | Preparation method for producing Qirong yang-invigorating oral liquid |
CN114652775A (en) * | 2020-12-22 | 2022-06-24 | 蛮力蛮(广州)医药科技有限公司 | External traditional Chinese medicine composition for nourishing penis |
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