CN1569047A - Novel method for preparing a liver benefiting medicine and its preparation - Google Patents
Novel method for preparing a liver benefiting medicine and its preparation Download PDFInfo
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- CN1569047A CN1569047A CN 03124653 CN03124653A CN1569047A CN 1569047 A CN1569047 A CN 1569047A CN 03124653 CN03124653 CN 03124653 CN 03124653 A CN03124653 A CN 03124653A CN 1569047 A CN1569047 A CN 1569047A
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Abstract
The invention discloses a novel method for preparing a liver benefiting medicine and its preparation, which overcomes the shortcoming of low biological availability of silymarin in the conventional preparation, the active constituents can be fully kept, and the preparation also has the advantages of good curative effect and easiness in carrying.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine, relates in particular to new preparation technology of silybum mariamum and herba swertiae contained liver-benefiting and preparation thereof.
Background technology
DANGFEI LIGANNING JIAONANG has eliminating damp-heat by Herba Silybi mariani, form when medicine two flavor Chinese medicines, and the function of the liver benefiting jaundice eliminating is used for retention and fumigation of damp-heat inside the body and the jaundice that causes, acute icterohepatitis, infectious hepatitis, chronic hepatitis and see damp and hot symptom person.Use through thousands of families hospital clinicals, determined curative effect, life-time service is not seen obvious toxic-side effects, taken in the 17 in the Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation, be national essential drugs, be the herbal species that state key is promoted.Its technology is: the Herba Silybi mariani fragmentation is deoiled, and uses 80% ethanol percolation, and diacolation liquid recycling ethanol is condensed into cream, gets Herba Silybi mariani total flavones; When the about 5% dozen of powder of medicine, remaining extracts with 95%, 75%, 50% ethanol gradient, filters, and is condensed into cream, adds when the medicine fine powder, and drying is made dry extract, adds above-mentioned Herba Silybi mariani total flavones and right amount of auxiliary materials, pulverizes mixing, encapsulated forming.
From Herba Silybi mariani, extract the Herba Silybi mariani total flavones of being carried (silymarin) and have the liver function of improvement, effects such as enhance hepatocyte film, clinically to acute, chronic hepatitis, liver cirrhosis, metabolism toxic liver injury etc. all has curative effect preferably, is one of main medicine for the treatment of at present diseases such as chronic hepatitis, liver cirrhosis.When medicine is a Gentianaceae Swertia plant, for institutes such as " Inner Mongol Chinese herbal medicine ", " Chinese medicine Ci hai " record, among the people being commonly called as " Herba hedyotis costatae ", its effective ingredient master is gentiopicrin, erythricine, sweroside, oleanolic acid etc., have protecting the liver, fall enzyme, antiinflammatory, heart tonifying, diuresis, effect such as anticancer, be to treat one of hepatitis definite effective medicine at present.
By as seen above-mentioned, the DANGFEI LIGANNING JIAONANG reasonable recipe, but with regard to its technology, can be further perfect.Modern pharmacy studies show that: solid orally ingestible is brought into play the precondition of curative effect in vivo, depends on the speed and the degree of medicine stripping or release from dosage form to a great extent.Herba Silybi mariani total flavones is several insoluble in water, when one of the main effective ingredient of medicine oleanolic acid is insoluble in water, has influenced the dissolution rate of effective ingredient in the preparation, bioavailability is low, limited its clinical practice and curative effect, thus its dissolubility improved, and then to improve its bioavailability be that the utmost point is necessary.Development along with pharmaceutical technology, the application of new adjuvant, compound adjuvant, surfactant etc., can solve the low and shortcoming that affects the treatment of its water solublity, as making solid dispersion with adjuvants such as PEG, PVP, make method such as clathrate improves its water solublity and improves rate of dissolution with suitable enclose material such as beta-schardinger dextrin-, HP-, thereby improve its clinical efficacy, make it have application prospect widely.This pharmaceutically dosage form is single simultaneously, and application forms still has only capsule, and this medicine quality standard is low, no quantitative target.Based on this, we use the modern pharmaceutical technology, technology to DANGFEI LIGANNING JIAONANG is improved necessarily, makes made medicine containing swertia psedochinensis and milk thistle silybum marianum can fully keep its effective ingredient, has good effect, the bioavailability height, take plurality of advantages such as easy to carry, improve its quality standard simultaneously, further satisfy and ensure people's medication demand, this is significant to inheriting and develop motherland's medicine legacy.
Summary of the invention
The purpose of this invention is to provide new preparation technology of a kind of silybum mariamum and herba swertiae contained liver-benefiting and preparation thereof, improve the quality of products and curative effect, increase the stability of product, has the bioavailability height, good effect is taken advantages such as easy to carry, further satisfies and ensured people's medication demand.
The objective of the invention is such realization:
Preparation technology and preparation thereof that silybum mariamum and herba swertiae contained liver-benefiting is new comprise the steps:
1. preparation technology that silybum mariamum and herba swertiae contained liver-benefiting is new and preparation thereof
1.1 after Herba Silybi mariani deoils in the prescription, adopt 60-95% ethanol extraction technology or extract or earlier with 60-95% ethanol extraction medicinal residues extraction process by water or obtain Herba Silybi mariani total flavones again with other technology that suits extraction with the ethyl acetate method; The Herba Silybi mariani total flavones of gained adopts suitable method that it is carried out solubilising, makes solid dispersion or makes clathrate or improve its water solublity and raising rate of dissolution with other suitable methods with suitable enclose material (as beta-schardinger dextrin-, HP-etc.) enclose as available suitable carrier (as PEG, PVP, poloxamer 188, sodium lauryl sulphate etc.).
1.2 adopt 95%, 75%, 50% ethanol gradient to extract or extraction process by water or part are played technology or other suitable technology extraction of powder extracting section again with 60-95% ethanol extraction medicinal residues earlier when medicine in the prescription.The available suitable carrier of the total extract of gained/high concentration ethanol extract part is made solid dispersion or is made clathrate or improve its water solublity and raising rate of dissolution or direct the application with other suitable methods with suitable enclose material enclose.
1.3 the extraction process fit applications of above-mentioned two medicines, through being prepared from various novel medicine containing swertia psedochinensis and milk thistle silybum marianums, as silybum mariamum and herba swertiae contained liver-benefiting sheet, silybum mariamum and herba swertiae contained liver-benefiting dispersible tablet, silybum mariamum and herba swertiae contained liver-benefiting ball, silybum mariamum and herba swertiae contained liver-benefiting micropill, silybum mariamum and herba swertiae contained liver-benefiting drop pill, DANGFEI LIGANNING JIAONANG or other suitable dosage forms; Prepared preparation can be conventional formulation, also can be the release preparation.
1.4 the preparation method of solid dispersion can adopt fusion method, solvent-fusion method or other suitable method in the technology; The weight ratio of extract and carrier is: 1: any ratio in the 1-200 scope; Prepared solid dispersion can contain an amount of surfactant.
1.5 the preparation method of clathrate can adopt solvent method, polishing, ultrasonic method, freeze-drying, spray drying method or other suitable method in the technology; The weight ratio of extract and enclose material is: 1: any ratio in the 1-200 scope.
1.6 the pulverizing medicinal materials of need extracting in the technology becomes coarse powder/be cut into decoction pieces to extract, and is generally 5-60 purpose coarse powder/be cut into decoction pieces, is preferably 20-40 order coarse powder; The medical material that need be ground into fine powder in the technology was ground into 80-160 purpose fine powder usually, and the best is standby for superfine powder is broken into 200-300 purpose fine powder.
1.7 the condition of alcohol extraction is in the technology: adopt 95%, 75%, 50% ethanol gradient extract/be solvent with the ethanol of 60-95%, adopt percolation or heating reflux method or other suitable method extraction.
1.8 the decocting condition of boiling is in the technology: decoct 2-3 time, amount of water is for doubly measuring for the 6-15 of dose for the first time, and second and third time doubly measured each 0.5-3 of time hour for the 4-12 of dose.
1.9 drying can adopt vacuum drying or spray drying or lyophilization or other suitable method in the technology.The vacuum drying temperature is controlled at 50-90 ℃, and the best is 60-70 ℃.Spray drying is for to be condensed into the concentrated solution that relative density is 1.03-1.25 (60 ℃) with extracting solution, and spray drying, inlet temperature are 100-200 ℃, and leaving air temp is 50-150 ℃.Best relative density is 1.05-1.15 (60 ℃), and inlet temperature is 150-170 ℃, and leaving air temp is 80-100 ℃.
Adopt concentrating under reduced pressure/thin film concentration/vacuum film to concentrate or other proper method 1.10 concentrate in the technology.
1.11 filterable method has a direct impact the size of preparation dose in the technology, can adopt conventional the filtration, and is centrifugal, ultrafiltration adds filtrations/centrifugal/ultrafiltration or other method that suits behind the clarifier.
1.12 used adjuvant can be sucrose, lactose, dextrin, starch, beta-schardinger dextrin-, HP-, PVP, PEG, poloxamer 188, tween 80, sodium lauryl sulphate, microcrystalline Cellulose, micropowder silica gel, hydroxypropyl cellulose, carboxymethylstach sodium, polyvinylpolypyrrolidone, Aspartane, stevioside, mannitol, sorbitol, 30 POVIDONE K 30 BP/USP in the technology
30Or other suitable adjuvant one or more be used.
1.13 the content of the DANGFEI LIGANNING JIAONANG that makes can be powder/granule/micropill, the Chinese crude drug of promptly writing out a prescription adopt suitable prepared powdered encapsulated/make encapsulated behind the granule/make behind the micropill encapsulated; The DANGFEI LIGANNING JIAONANG of routine can be, also medicine containing swertia psedochinensis and milk thistle silybum marianum release capsule or other suitable DANGFEI LIGANNING JIAONANG can be with release ability.
1.14 the silybum mariamum and herba swertiae contained liver-benefiting tablet that makes can be used suitable coating material coating, one or more are used as stomach dissolution type film-coat pre-mixing agent (Opadry), hydroxypropyl cellulose or other suitable material; According to the difference of used adjuvant, can or have silybum mariamum and herba swertiae contained liver-benefiting release sheet or other the suitable silybum mariamum and herba swertiae contained liver-benefiting tablet that speed collapses the silybum mariamum and herba swertiae contained liver-benefiting dispersible tablet of ability or has the release ability for common silybum mariamum and herba swertiae contained liver-benefiting sheet.
1.15 prepared silybum mariamum and herba swertiae contained liver-benefiting ball can be various types of balls; Prepared ball can be used suitable coating material coating.
2. the quality control of medicine containing swertia psedochinensis and milk thistle silybum marianum
On differentiating, existing DANGFEI LIGANNING JIAONANG is now kept having carried out the thin layer discriminating when medicine, and has increased the thin layer discriminating to Herba Silybi mariani; On checking, increased to heavy metal must not cross 10/1000000ths, arsenic salt must not cross 2/1000000ths limit examine; On assay, existing preparation does not have quantitative target, and is existing to having carried out quantitatively when medicine.
This invention is compared with prior art: production technology more becomes to improving rationally, adopt the prepared medicine containing swertia psedochinensis and milk thistle silybum marianum of the present invention to have good bioavailability, can fully keep its effective ingredient, has good effect, take advantages such as easy to carry, improve its quality standard simultaneously comprehensively, enriched medicine variety, further satisfy and ensured people's medication needs.
The specific embodiment
Following embodiment can be for reference in order to further specify the present invention, but do not limit the scope of the invention thus.
Embodiment 1: the preparation of DANGFEI LIGANNING JIAONANG
Two flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Become coarse powder standby two flavor medicine pulverize separately; Get the Herba Silybi mariani fragmentation, after deoiling, the ethanol with 80% is solvent, and slowly percolation is collected the liquid of filtering, and decompression recycling ethanol is condensed into cream, and is standby; Get appropriate amount of PEG 6000 in 70 ℃ of heating and meltings, above-mentioned Herba Silybi mariani total flavones adds tween 80 and a small amount of anhydrous alcohol solution, and with PEG6000 fused mass mixing, cooling is solidified, and pulverizes, and it is standby to cross 80 mesh sieves; When medicinal 90% alcohol heating reflux extraction 2 times, merge extractive liquid, filters, and filtrate recycling ethanol is standby; Medicinal residues decoct with water 2 times, and collecting decoction filters, and the alcohol extract behind filtrate and the above-mentioned recovery ethanol merges, and are concentrated in right amount, and spray drying is collected dried cream powder, and is encapsulated with above-mentioned Herba Silybi mariani solid dispersion and appropriate amount of auxiliary materials mixing, promptly.
Embodiment 2: the preparation of DANGFEI LIGANNING JIAONANG
Two flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Become coarse powder standby two flavor medicine pulverize separately; Get the Herba Silybi mariani fragmentation, after deoiling, the ethanol with 80% is solvent, heating and refluxing extraction 3 times, and extracting solution merges, ultrafiltration, decompression filtrate recycling ethanol, it is standby that concentrate drying is made dried cream powder; Get appropriate amount of PEG 6000 in 70 ℃ of heating and meltings, above-mentioned dried cream powder adds tween 80 and a small amount of anhydrous alcohol solution, and with PEG6000 fused mass mixing, cooling is solidified, and pulverizes, and it is standby to cross 80 mesh sieves; When carrying out gradient, extracts by medicinal 95%, 75%, 50% ethanol, the extracting solution ultrafiltration, and merging filtrate reclaims ethanol, is concentrated in right amount, and spray drying is collected dried cream powder, with above-mentioned Herba Silybi mariani solid dispersion and appropriate amount of auxiliary materials mixing, makes micropill, and is encapsulated, promptly.
Embodiment 3: the preparation of silybum mariamum and herba swertiae contained liver-benefiting sheet
Two flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Become coarse powder standby two flavor medicine pulverize separately; Get the Herba Silybi mariani fragmentation, after deoiling, the ethanol with 80% is solvent, heating and refluxing extraction 3 times, and extracting solution merges, ultrafiltration, decompression filtrate recycling ethanol, it is standby that concentrate drying is made dried cream powder; Get an amount of sodium lauryl sulphate in 70 ℃ of heating and meltings, add above-mentioned dried cream powder mixing, cooling is solidified, and pulverizes, and it is standby to cross 80 mesh sieves; When carrying out gradient, extracts by medicinal 95%, 75%, 50% ethanol, the extracting solution ultrafiltration, and merging filtrate reclaims ethanol, is concentrated in right amount, and spray drying is collected dried cream powder, with above-mentioned Herba Silybi mariani solid dispersion and appropriate amount of auxiliary materials mixing, directly/the back tabletting of granulating, promptly.
Embodiment 4: the preparation of silybum mariamum and herba swertiae contained liver-benefiting sheet
Two flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Become coarse powder standby two flavor medicine pulverize separately; Get the Herba Silybi mariani fragmentation, after deoiling, the ethanol with 80% is solvent, heating and refluxing extraction 3 times, and extracting solution merges, ultrafiltration, decompression filtrate recycling ethanol is condensed into cream, and it is standby to get Herba Silybi mariani total flavones; Get an amount of HP-and add the suitable quantity of water dissolving, stir/the ultrasonic alcoholic solution that slowly drips above-mentioned Herba Silybi mariani total flavones down, continue to stir/ultrasonic to the stipulated time, membrane filtration with reuse 0.22 μ behind the membrane filtration of 0.45 μ, the solution concentration of gained is to an amount of, spray drying, it is standby to collect dried cream powder; When carrying out gradient, extracts by medicinal 95%, 75%, 50% ethanol, the extracting solution ultrafiltration, and merging filtrate reclaims ethanol, be concentrated in right amount, spray drying is collected dried cream powder, with above-mentioned Herba Silybi mariani cyclodextrin clathrate and appropriate amount of auxiliary materials mixing, directly/the back tabletting of granulating, promptly.
Embodiment 5: the preparation of silybum mariamum and herba swertiae contained liver-benefiting ball
Two flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Getting Herba Silybi mariani, to be ground into coarse powder standby; The 5-20% that gets when the about recipe quantity of medicine is ground into fine powder, and remaining works as medicated powder, and to be broken into coarse powder standby; Get the Herba Silybi mariani fragmentation, after deoiling, use ethyl acetate heating and refluxing extraction 3-4 time, the reclaim under reduced pressure ethyl acetate, it is standby to get Herba Silybi mariani total flavones; Get appropriate amount of PEG 6000 in 70 ℃ of heating and meltings, above-mentioned Herba Silybi mariani total flavones adds tween 80 and a small amount of anhydrous alcohol solution, and with PEG6000 fused mass mixing, cooling is solidified, and pulverizes, and it is standby to cross 80 mesh sieves; Get when the medicine coarse powder and extract 2 times with 95% alcohol heating reflux, merge extractive liquid,, filtration, filtrate recycling ethanol is standby; Medicinal residues decoct with water 2 times, and collecting decoction filters, and the alcohol extract behind filtrate and the above-mentioned recovery ethanol merges, and is condensed into thick paste, with above-mentioned medicine fine powder, Herba Silybi mariani solid dispersion and the appropriate amount of auxiliary materials mixing of working as, pill, vacuum drying, promptly.
Embodiment 6: the preparation of silybum mariamum and herba swertiae contained liver-benefiting micropill
Two flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Become coarse powder standby two flavor medicine pulverize separately; Get the Herba Silybi mariani fragmentation, after deoiling, the ethanol with 80% is solvent, heating and refluxing extraction 3 times, and extracting solution merges, ultrafiltration, decompression filtrate recycling ethanol is condensed into cream, and it is standby to get Herba Silybi mariani total flavones; It is standby that above-mentioned Herba Silybi mariani total flavones and beta-cyclodextrin inclusion compound are made Benexate Hydrochloride; Ethanol when medicinal 95% adds stream and extracts 2 times, and each 1 hour, the extracting solution ultrafiltration, merging filtrate reclaims ethanol, is concentrated in right amount, and to make Benexate Hydrochloride standby with beta-cyclodextrin inclusion compound; Medicinal residues decoct with water 2 times, and each 1.5 hours, the medicinal liquid ultrafiltration was condensed into thick paste, with above-mentioned Herba Silybi mariani Benexate Hydrochloride, when medicated bag compound and appropriate amount of auxiliary materials mixing, make micropill, vacuum drying, promptly.
Embodiment 7: the preparation of silybum mariamum and herba swertiae contained liver-benefiting drop pill
Two flavor medicines are cleaned respectively, remove impurity, it is standby to be up to the standards; Become coarse powder standby two flavor medicine pulverize separately; Get the Herba Silybi mariani fragmentation, after deoiling, the ethanol with 80% is solvent, and slowly percolation is collected the liquid of filtering, and decompression recycling ethanol is standby; When medicinal 95% alcohol heating reflux extraction 2 times, merge extractive liquid, filters, and filtrate recycling ethanol is standby; Medicinal residues decoct with water 2 times, and collecting decoction filters, and filtrate and above-mentioned Herba Silybi mariani and the alcohol extract behind the recovery ethanol of medicine merge, and are condensed into thick paste, and be standby with an amount of tween 80 mixing; Get appropriate amount of PEG 6000 water-soluble heating and meltings, add above-mentioned thick paste, stir evenly, splash in the coolant, collect drop pill, the shampooing ball, drying, promptly
Claims (9)
1, preparation method that a kind of silybum mariamum and herba swertiae contained liver-benefiting is new and preparation thereof is characterized in that:
(1) after Herba Silybi mariani deoils in the prescription, adopt 60-95% ethanol extraction technology/usefulness ethyl acetate method to extract; Or earlier with 60-95% ethanol extraction medicinal residues again the technology extraction of beating the powder extracting section of extraction process by water/part obtain Herba Silybi mariani total flavones, the Herba Silybi mariani total flavones of gained adopts the method for making solid dispersion/make clathrate that it is carried out solubilising, and make solid dispersion/use the enclose material as available support: PVP, PEG, poloxamer 188, sodium lauryl sulphate: beta-schardinger dextrin-, HP-enclose are made clathrate and improved its water solublity and raising rate of dissolution;
(2) in the prescription when medicine adopt 95%, 75%, 50% ethanol gradient extractions/elder generation with 60-95% ethanol extraction medicinal residues again extraction process by water/part play the technology extraction of powder extracting section, the total extract of gained/high concentration ethanol extract part available support makes that solid dispersion/making clathrate with enclose material enclose improves its water solublity and also can directly use with the raising rate of dissolution;
(3) through the extraction process fit applications of (1), (2) two medicines, be prepared from the novel medicine containing swertia psedochinensis and milk thistle silybum marianum that can show the new technology characteristic: silybum mariamum and herba swertiae contained liver-benefiting sheet, silybum mariamum and herba swertiae contained liver-benefiting dispersible tablet, silybum mariamum and herba swertiae contained liver-benefiting ball, silybum mariamum and herba swertiae contained liver-benefiting micropill, silybum mariamum and herba swertiae contained liver-benefiting drop pill, DANGFEI LIGANNING JIAONANG; Prepared preparation can be conventional formulation, also can be the release preparation.
2, preparation technology and the preparation thereof new according to the described silybum mariamum and herba swertiae contained liver-benefiting of claim 1 is characterized in that:
(1) content of prepared DANGFEI LIGANNING JIAONANG can be powder/granule/micropill, is common DANGFEI LIGANNING JIAONANG, also can be for having the silybum mariamum and herba swertiae contained liver-benefiting release capsule of release ability.
(2) prepared silybum mariamum and herba swertiae contained liver-benefiting tablet can be used the coating material coating, according to the difference of used adjuvant, can collapse the silybum mariamum and herba swertiae contained liver-benefiting dispersible tablet of ability/the have silybum mariamum and herba swertiae contained liver-benefiting release sheet of release ability for common silybum mariamum and herba swertiae contained liver-benefiting sheet/have speed.
(3) prepared silybum mariamum and herba swertiae contained liver-benefiting ball can be honeyed pill, water pill, micropill, drop pill, and prepared ball can be used the coating material coating;
3, preparation technology that silybum mariamum and herba swertiae contained liver-benefiting according to claim 1 is new and preparation thereof is characterized in that:
(1) preparation method of solid dispersion can adopt fusion method, solvent-fusion method in the technology, and the weight ratio of extract and carrier is: 1: any ratio in the 1-200 scope, prepared solid dispersion can contain an amount of surfactant.
(2) preparation method of clathrate can adopt solvent method, polishing, ultrasonic method, freeze-drying, spray drying method in the technology, and the weight ratio of extract and enclose material is: 1: any ratio in the 1-200 scope.
4, preparation technology that silybum mariamum and herba swertiae contained liver-benefiting according to claim 1 is new and preparation thereof is characterized in that: the pulverizing medicinal materials of need extracting in the technology becomes coarse powder/be cut into decoction pieces to extract, and is generally 5-60 purpose coarse powder/be cut into decoction pieces, and the best was a 20-40 order coarse powder; The medical material that need be ground into fine powder in the technology was ground into 80-160 purpose fine powder usually, and the best is standby for superfine powder is broken into 200-300 purpose fine powder.
5, preparation technology and the preparation thereof new according to the described silybum mariamum and herba swertiae contained liver-benefiting of claim 1, it is characterized in that: drying can adopt vacuum drying/spray drying/lyophilization in the technology.
6, preparation technology and the preparation thereof new according to the described silybum mariamum and herba swertiae contained liver-benefiting of claim 1 is characterized in that: concentrate in the technology and adopt concentrating under reduced pressure/thin film concentration/vacuum film to concentrate.
7, preparation technology and the preparation thereof new according to the described silybum mariamum and herba swertiae contained liver-benefiting of claim 1 is characterized in that: filter in the technology and can adopt conventional the filtration, centrifugal, ultrafiltration adds filtration/centrifugal/ultrafiltration behind the clarifier.
8, preparation technology and the preparation thereof new according to the described silybum mariamum and herba swertiae contained liver-benefiting of claim 1, it is characterized in that: used adjuvant can be sucrose, lactose, dextrin, starch, beta-schardinger dextrin-, HP-, PVP, PEG, poloxamer 188, tween 80, sodium lauryl sulphate, microcrystalline Cellulose, micropowder silica gel, hydroxypropyl cellulose, carboxymethylstach sodium, polyvinylpolypyrrolidone, Aspartane, stevioside, mannitol, sorbitol, 30 POVIDONE K 30 BP/USP in the technology
30A kind of/multiple being used.
9, preparation technology and the preparation thereof new according to the described silybum mariamum and herba swertiae contained liver-benefiting of claim 1, it is characterized in that: the quality standard of medicine containing swertia psedochinensis and milk thistle silybum marianum has carried out the thin layer discriminating to Herba Silybi mariani on differentiating, have that heavy metal must not cross 10/1000000ths, arsenic salt must not be crossed 2/1000000ths limit examine, on assay to having carried out quantitatively when medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03124653 CN1569047A (en) | 2003-07-13 | 2003-07-13 | Novel method for preparing a liver benefiting medicine and its preparation |
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| CN 03124653 CN1569047A (en) | 2003-07-13 | 2003-07-13 | Novel method for preparing a liver benefiting medicine and its preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101164537B (en) * | 2006-10-16 | 2010-08-25 | 江苏大学 | High-efficient oral silibinin sustained-release preparation and preparation method thereof |
| CN1872050B (en) * | 2005-06-01 | 2010-12-01 | 天津天士力制药股份有限公司 | Drop pills of silymarin, and preparation method |
| CN106008484A (en) * | 2016-07-29 | 2016-10-12 | 内蒙古昶辉生物科技股份有限公司 | Silibinin extraction method |
| CN111494564A (en) * | 2020-04-30 | 2020-08-07 | 江苏中兴药业有限公司 | Preparation method of compound liver-protecting and alcohol-dispelling tablet |
-
2003
- 2003-07-13 CN CN 03124653 patent/CN1569047A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872050B (en) * | 2005-06-01 | 2010-12-01 | 天津天士力制药股份有限公司 | Drop pills of silymarin, and preparation method |
| CN101164537B (en) * | 2006-10-16 | 2010-08-25 | 江苏大学 | High-efficient oral silibinin sustained-release preparation and preparation method thereof |
| CN106008484A (en) * | 2016-07-29 | 2016-10-12 | 内蒙古昶辉生物科技股份有限公司 | Silibinin extraction method |
| CN111494564A (en) * | 2020-04-30 | 2020-08-07 | 江苏中兴药业有限公司 | Preparation method of compound liver-protecting and alcohol-dispelling tablet |
| CN111494564B (en) * | 2020-04-30 | 2021-07-27 | 江苏中兴药业有限公司 | Preparation method of compound liver-protecting and alcohol-dispelling tablet |
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