CN1565529A - Dripping pills preparation for treating angioneurotic headache - Google Patents
Dripping pills preparation for treating angioneurotic headache Download PDFInfo
- Publication number
- CN1565529A CN1565529A CN 03132116 CN03132116A CN1565529A CN 1565529 A CN1565529 A CN 1565529A CN 03132116 CN03132116 CN 03132116 CN 03132116 A CN03132116 A CN 03132116A CN 1565529 A CN1565529 A CN 1565529A
- Authority
- CN
- China
- Prior art keywords
- conditions
- headache
- angioneurotic headache
- ethanol
- reduced pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides dripping pills preparation for treating angioneurotic headache, wherein the principal raw materials include Ligusticum wallichii and gastrodia tuber by the weight ratio of Ligusticum wallichii : gastrodia elata = 2-5 : 1. The dripping pills have substantial thrombosis resistance action.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of angioneurotic headache, specifically a kind of dropping pill formulation for the treatment of angioneurotic headache.
Background technology
Angioneurotic headache also claims vascular headache, and its cause of disease is intricate, and is not clear fully as yet, and the dysfunction and the cerebral cortex layer function imbalance institute that are commonly considered as cerebrovascular contraction and diastole cause.
Show that according to domestic and international statistics the sickness rate of angioneurotic headache accounts for more than 10% of total population, the sickness rate of child's angioneurotic headache is about 4～10%.This disease is the sickness rate height not only, and when outbreak patient comparatively painful, outbreak is not healed for a long time repeatedly, weight person even can seriously have influence on patient's work, study and quality of life.Continuous quickening along with modern society's rhythm of life, the sickness rate of angioneurotic headache increases year by year, listed one of modern society's common disease spectrum in, in the nearest investigation of WHO, the serious symptom angioneurotic headache, with quadriplegia, psychosis, dementia, be listed in and make one of incapabitated chronic disease of people.
At present clinical main medicine and other method that is used for treating angioneurotic headache of doctor trained in Western medicine has: cervical sympathetic nerve, the outer blood vessel of ligation cranium etc. are cut off in vasoconstrictor, 5-hydroxytryptamine receptor agonist, anticoagulant, calcium ion antagonist, beta-blocker, tranquilizer, high pressure oxygen uptake and operation, but curative effect is all not ideal enough, and especially late result is more unreliable.Therefore, in China, existing at present more doctor and patient begins to adopt tcm therapy to treat this disease.
Angioneurotic headache is plain on Chinese medicine to be referred to as with " wind syndrome of head ", " headache caused by pathogenic wind ", " headache ", " migraine ".The Chinese traditional treatment headache is of long standing and well established, has accumulated abundant clinical experience and has formed comparatively complete theoretical system.In the treatment often with expelling wind and cold, nourshing blood and promoting blood circulation, the rule of treatment such as disperse blood stasis and dredge collateral are main." Daqiong pill " is the migrainous classics side of Chinese traditional treatment.Record Daqiong pill among the Song Zhaoji " Shengji Zonglu " " control wind syndrome of head and revolve dizzyly, the dizzy urgency of blurred vision should go yang channel wind and cold, changes and leads the chest and diaphragm phlegm retention, controls migraine and general headache, separate health arrest tired, salubrious mind, tonneau pass key ".This side has been subjected to the high evaluation of ancient Chinese medicine doctor since coming out, treat migrainous first-selected good recipe for tcm clinical practice, also is to be fit to modern spectrum of disease, the herbal species with great market prospect.Tianjin Inst. of Materia Medica, Kangyuan Pharmaceutical Co., Ltd., Jiangsu Prov have developed jointly a day relieving capsule on this basis, are used for the treatment of vascular headache, and Kangyuan Pharmaceutical Co., Ltd., Jiangsu Prov has intellectual property completely to this kind.It relieving capsule after putting on market in 1998, because safe, effective, quality controllable, market efficiency is better.
Summary of the invention
The present invention is on the basis of Chemistry for Chinese Traditional Medicine, pharmacological toxicology, production and the clinical research achievement of summing up day relieving capsule, in conjunction with existing latest find of seminar and achievement in research, using modern crafts means, analytical technology and pharmacological screening means furthers investigate, " Daqiong pill " carried out secondary development, and initiative is used for the treatment of the modern Chinese medicine new drug of vascular headache.
The technical problem to be solved in the present invention is achieved through the following technical solutions, and primary raw material of the present invention is Rhizoma Chuanxiong, Rhizoma Gastrodiae, its weight proportion Rhizoma Chuanxiong: Rhizoma Gastrodiae is 2～5: 1
Its preparation method is:
Get Rhizoma Chuanxiong and Rhizoma Gastrodiae decoction pieces respectively,, be ground into coarse powder 40～60 ℃ of dryings, with 60% ethanol extraction secondary, 1.5 hours for the first time, 6 times of amount ethanol; 1 hour for the second time, 4 times of amount ethanol.Merge extractive liquid,,-0.09～-be evaporated under 0.06Mpa and 60～80 ℃ of conditions and do not have the alcohol flavor, use the water saturation n-butanol extraction, extract-0.09～-0.06Mpa and 60～80 ℃ of conditions under reclaim under reduced pressure during to 50 ℃ of relative densities 1.30～1.35,-0.09～-0.06Mpa and 60 ℃ of conditions under drying under reduced pressure to there being the n-butyl alcohol flavor, with 20 times of water gaging suspendibles, use absorption with macroporous adsorbent resin, wash the deresination post then with water, again with 30% ethanol to the adsorbent resin eluting, collect eluent ,-0.09～-after concentrating under 0.06Mpa and 60～80 ℃ of conditions, 60 ℃ of drying under reduced pressure get extract powder.With Polyethylene Glycol-4000 and extract powder with 3～6: 1～4 ratio melting mixing, methyl-silicone oil is made coolant, drips to make ball, promptly.
Annotate: the prepared slices of Chinese crude drugs refer to clean and cut into chunks or the Chinese crude drug of sheet
Coarse powder: medical material processing term, particle diameter be more than 100 microns, but owing to the equipment reason, fine powder is also arranged therein, so coarse powder is not described further.
The active substance basis of dropping pill formulation of the present invention mainly is based on phenolic substance, phthalide derivant, contain gastrodine, p-Hydroxybenzylalcohol, Vanillin, cephrol, cnidium lactone, chuanxingol etc. after testing, find to contain organic acid such as ferulic acid etc. simultaneously, also have ligustrazine etc. in addition.In the dropping pill formulation of the present invention, active substance phenolic substance, phthalide derivant total content are to make 20～70% of the preceding extract powder of drop pill.
Pharmacological testing
1000 capsules were made with the 1000g crude drug by relieving capsule system in former day, and promptly every capsules is equivalent to the 1g crude drug.Its dose is 9～12/day, be equivalent to 9～12g crude drug in whole (Rhizoma Chuanxiong: Rhizoma Gastrodiae=4: 1), i.e. 0.15～0.2g crude drug/kg body weight (body weight for humans press 60kg calculate).Give KM mouse stomach (2g/kg) with extractum of the present invention according to the clinical equivalent amount, measure the variation of its pain threshold, the results are shown in Table 1 and table 2 (A: extractum of the present invention; G: day relieving capsule group; H: normal group).
Table 1: medicine is to the influence of mice pain threshold (hot plate method, n=10, X ± SD)
Group dosage (is equivalent to pain threshold (s)
Crude drug g/kg)
0.5h 1h 2h 4h
A 2 49.5±22.1
**?39.2±22.6 45.5±18.6
**?44.2±20.5
*
G 2 39.8±20.2
* 38.6±21.5 40.8±21.2
* 41.5±19.5
*
H 20.4±8.5 21.6±7.2 25.9±7.9 26.2±7.6
Aspirin 0.6g/kg 32.6 ± 17.8 42.8 ± 15.6
*41.4 ± 17.2
*49.2 ± 18.3
*
H is a normal group, compares with normal group
*P＜0.05,
*P＜0.01
Table 2 thrombotest result
The 30min eye socket is got blood after the mice administration, and the survey clotting time (X ± SD)
Group dosage clotting time (s) P value
A 2g/kg 206.8±19.0 0.0019
**
G 2g/kg 180.1±70.0 0.019
*
H 83.6±5.7
*P＜0.05
**P＜0.01
Above-mentioned experiment shows that dropping pill formulation of the present invention has significant analgesia and blood coagulation resisting function.
The specific embodiment
Take by weighing Rhizoma Chuanxiong 784g Rhizoma Gastrodiae 196g
Get Rhizoma Chuanxiong and Rhizoma Gastrodiae decoction pieces respectively,, be ground into coarse powder 40～60 ℃ of dryings, with 60% ethanol extraction secondary, 1.5 hours for the first time, 6 times of amount ethanol; 1 hour for the second time, 4 times of amount ethanol.Merge extractive liquid,,-0.09～-be evaporated under 0.06Mpa and 60～80 ℃ of conditions and do not have the alcohol flavor, use the water saturation n-butanol extraction, extract-0.09～-0.06Mpa and 60～80 ℃ of conditions under reclaim under reduced pressure during to 50 ℃ of relative densities 1.30～1.35,-0.09～-0.06Mpa and 60 ℃ of conditions under drying under reduced pressure to there being the n-butyl alcohol flavor, with 20 times of water gaging suspendibles, use absorption with macroporous adsorbent resin, wash the deresination post then with water, again with 30% ethanol to the adsorbent resin eluting, collect eluent ,-0.09～-after concentrating under 0.06Mpa and 60～80 ℃ of conditions, 60 ℃ of drying under reduced pressure get extract powder.With Polyethylene Glycol-4000 and extract powder with 3～6: 1～4 ratio melting mixing, methyl-silicone oil is made coolant, drips to make ball, promptly.The 50mg/ grain contains extractum 20mg, takes 3～4 at every turn, every day three times.
Claims (4)
1. dropping pill formulation for the treatment of angioneurotic headache, primary raw material is Rhizoma Chuanxiong, Rhizoma Gastrodiae, is characterized in the weight proportion of primary raw material: Rhizoma Chuanxiong: Rhizoma Gastrodiae is 2～5: 1
Its preparation method is:
Get Rhizoma Chuanxiong and Rhizoma Gastrodiae decoction pieces respectively,, be ground into coarse powder 40～60 ℃ of dryings, with 60% ethanol extraction secondary, 1.5 hours for the first time, 6 times of amount ethanol; 1 hour for the second time, 4 times of amount ethanol.Merge extractive liquid,,-0.09～-be evaporated under 0.06Mpa and 60～80 ℃ of conditions and do not have the alcohol flavor, use the water saturation n-butanol extraction, extract-0.09～-0.06Mpa and 60～80 ℃ of conditions under reclaim under reduced pressure during to 50 ℃ of relative densities 1.30～1.35,-0.09～-0.06Mpa and 60 ℃ of conditions under drying under reduced pressure to there being the n-butyl alcohol flavor, with 20 times of water gaging suspendibles, use absorption with macroporous adsorbent resin, wash the deresination post then with water, again with 30% ethanol to the adsorbent resin eluting, collect eluent ,-0.09～-after concentrating under 0.06Mpa and 60～80 ℃ of conditions, 60 ℃ of drying under reduced pressure, extract powder, with Polyethylene Glycol-4000 and extract powder with 3～6: 1～4 ratio melting mixing, methyl-silicone oil is made coolant, drip and make ball, promptly.
2. the dropping pill formulation of treatment angioneurotic headache as claimed in claim 1 is characterized in that: its active substance mainly comprises phenolic substance, phthalide derivant.
3. the dropping pill formulation of treatment angioneurotic headache as claimed in claim 2 is characterized in that: its active substance is gastrodine, cnidium lactone, chuanxingol, ferulic acid, ligustrazine etc.
4. as the dropping pill formulation of claim 2 or 3 described treatment angioneurotic headaches, it is characterized in that: its active substance phenolic substance, phthalide derivant total content are to make 20～70% of the preceding extract powder of drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03132116XA CN100417406C (en) | 2003-06-24 | 2003-06-24 | Dripping pills preparation for treating angioneurotic headache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03132116XA CN100417406C (en) | 2003-06-24 | 2003-06-24 | Dripping pills preparation for treating angioneurotic headache |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1565529A true CN1565529A (en) | 2005-01-19 |
| CN100417406C CN100417406C (en) | 2008-09-10 |
Family
ID=34469876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB03132116XA Expired - Lifetime CN100417406C (en) | 2003-06-24 | 2003-06-24 | Dripping pills preparation for treating angioneurotic headache |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100417406C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100589831C (en) * | 2006-05-31 | 2010-02-17 | 本溪市中心医院 | Dry powder preparation of chuanxiong rhizome and its preparation method |
| CN102091240A (en) * | 2011-01-24 | 2011-06-15 | 南京中医药大学 | Szechuan lovage rhizome formula micro emulsion nasal delivery preparation and preparation method and application thereof |
| CN102846967A (en) * | 2011-06-29 | 2013-01-02 | 湖南中医药大学 | A pure-component Chinese medicinal preparation for treating headache and its preparation process |
| CN103125928A (en) * | 2011-11-30 | 2013-06-05 | 陕西理工学院 | Preparation method of gastrodia elata essence |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067901C (en) * | 1998-12-03 | 2001-07-04 | 成都中医药大学 | Drug for curing migraine and its preparing method |
-
2003
- 2003-06-24 CN CNB03132116XA patent/CN100417406C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100589831C (en) * | 2006-05-31 | 2010-02-17 | 本溪市中心医院 | Dry powder preparation of chuanxiong rhizome and its preparation method |
| CN102091240A (en) * | 2011-01-24 | 2011-06-15 | 南京中医药大学 | Szechuan lovage rhizome formula micro emulsion nasal delivery preparation and preparation method and application thereof |
| CN102091240B (en) * | 2011-01-24 | 2012-07-04 | 南京中医药大学 | Szechuan lovage rhizome formula micro emulsion nasal delivery preparation and preparation method and application thereof |
| CN102846967A (en) * | 2011-06-29 | 2013-01-02 | 湖南中医药大学 | A pure-component Chinese medicinal preparation for treating headache and its preparation process |
| CN102846967B (en) * | 2011-06-29 | 2015-08-26 | 湖南中医药大学 | A kind of pure component Chinese medicine preparation and preparation technology treating headache |
| CN103125928A (en) * | 2011-11-30 | 2013-06-05 | 陕西理工学院 | Preparation method of gastrodia elata essence |
| CN103125928B (en) * | 2011-11-30 | 2014-07-09 | 陕西理工学院 | Preparation method of gastrodia elata essence |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100417406C (en) | 2008-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101214270B (en) | Acanthopanax senticosus effective fraction extract, preparation and application thereof | |
| CN1857664A (en) | Apoplexy treating preparation and its preparing process | |
| CN101062080A (en) | Medicinal composition for relieving fatigue and preparing process thereof | |
| CN1861122A (en) | Traditional Chinese medicine prepn. used for treating apoplexia and obstruction of qi in the chest, and its prepn. method | |
| CN1814170B (en) | Medicinal drop pills for treating cardiovascular disease and preparing method | |
| CN100417406C (en) | Dripping pills preparation for treating angioneurotic headache | |
| CN104906212A (en) | Semen hoveniae extracts with liver protection function and extraction and separation method and application thereof | |
| CN1775229A (en) | Chinese medicine dropping pill for promoting blood circulation, removing blood stasis, alleviating pain and detumescence and its preparing method | |
| CN1709417A (en) | Ainsliaea fragrans champ extract and its preparing method | |
| CN1562183A (en) | Chinese medica preparation for curing hyperplasia of mammary glands and preparation method | |
| CN103006781B (en) | Compound Dai medicine extract with liver-protecting effect and preparation method thereof | |
| CN111617193B (en) | Qinglong stopping particle | |
| CN1771978A (en) | Notoginseng triol-saponin composition and its prepn and use | |
| CN1199643C (en) | Use of timosaponin for preparing medicine for preventing and treating brain apoplexy | |
| CN110613789B (en) | Chinese medicinal composition for treating drug addiction and its preparation method | |
| CN1068782C (en) | Anti-cancer medicine with extracts from goldenrain and the preparation thereof | |
| CN1839931B (en) | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof | |
| CN115317582B (en) | Eye patch for improving eyesight and soothing eyes | |
| CN1698769A (en) | Bupleurum root soft capsule and its preparation method | |
| CN107551099A (en) | It is a kind of to be used to treat Chinese medicine composition of senile dementia and preparation method thereof | |
| CN1090968C (en) | Chinese-medicinal analgesic and sedative and preparing process thereof | |
| CN1634241A (en) | Compound formulation of notoginseng for treating cardiovascular and cerebrovascular diseases and its preparing process | |
| CN108295040A (en) | Yuxintong capsules preparation method | |
| CN102309550A (en) | Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof | |
| CN105663529A (en) | Traditional Chinese medicinal composition for treating depression and preparation method of traditional Chinese medicinal composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20080910 |