CN1562873A - Method for preparing bioceramic in complex phase of hydroxyapatite and beta triealcium phosphate - Google Patents
Method for preparing bioceramic in complex phase of hydroxyapatite and beta triealcium phosphate Download PDFInfo
- Publication number
- CN1562873A CN1562873A CN 200410030651 CN200410030651A CN1562873A CN 1562873 A CN1562873 A CN 1562873A CN 200410030651 CN200410030651 CN 200410030651 CN 200410030651 A CN200410030651 A CN 200410030651A CN 1562873 A CN1562873 A CN 1562873A
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- China
- Prior art keywords
- bata
- tricalcium phosphate
- hydroxyapatite
- complex phase
- dry
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims description 20
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 6
- 239000003462 bioceramic Substances 0.000 title description 2
- 229910019142 PO4 Inorganic materials 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- 239000000843 powder Substances 0.000 claims abstract description 19
- 238000003825 pressing Methods 0.000 claims abstract description 16
- 239000000919 ceramic Substances 0.000 claims abstract description 14
- 239000011521 glass Substances 0.000 claims abstract description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 7
- 239000001506 calcium phosphate Substances 0.000 claims description 24
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 24
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- JKWMSGQKBLHBQQ-UHFFFAOYSA-N diboron trioxide Chemical compound O=BOB=O JKWMSGQKBLHBQQ-UHFFFAOYSA-N 0.000 claims description 10
- GNTDGMZSJNCJKK-UHFFFAOYSA-N divanadium pentaoxide Chemical compound O=[V](=O)O[V](=O)=O GNTDGMZSJNCJKK-UHFFFAOYSA-N 0.000 claims description 10
- 239000000395 magnesium oxide Substances 0.000 claims description 10
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 10
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 10
- 238000005245 sintering Methods 0.000 claims description 9
- 238000000498 ball milling Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 229910004298 SiO 2 Inorganic materials 0.000 claims description 5
- MCMNRKCIXSYSNV-UHFFFAOYSA-N ZrO2 Inorganic materials O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 5
- 230000004927 fusion Effects 0.000 claims description 5
- ORUIBWPALBXDOA-UHFFFAOYSA-L magnesium fluoride Chemical compound [F-].[F-].[Mg+2] ORUIBWPALBXDOA-UHFFFAOYSA-L 0.000 claims description 5
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims description 5
- CHWRSCGUEQEHOH-UHFFFAOYSA-N potassium oxide Chemical compound [O-2].[K+].[K+] CHWRSCGUEQEHOH-UHFFFAOYSA-N 0.000 claims description 5
- 229910001950 potassium oxide Inorganic materials 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- 235000012239 silicon dioxide Nutrition 0.000 claims description 5
- 229960001866 silicon dioxide Drugs 0.000 claims description 5
- 239000000758 substrate Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 210000000988 bone and bone Anatomy 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000002131 composite material Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Materials For Medical Uses (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
In the invention, biological glass powder (weight percentage is 5-15) is added in oxhydryl kietyoite powder to be formed by dry pressing on pressure 10-30 Mpa, then to be fired in temp. 1050-1250 deg.C to produce compound biological ceramics of oxhydryl kietyoite and beta-tricalcium phosphate that content can be controlled.
Description
Technical field
The invention belongs to the preparing technical field of degradable biological medical material, specially refer to the preparation method of a kind of degradable hydroxyapatite and bata-tricalcium phosphate complex phase bioceramic material.
Background technology
The inorganic components of the chemical constitution of hydroxyapatite and bata-tricalcium phosphate and human body bone is close, is the very important bone renovating materials of two classes, and its preparation technology and performance study are one of focuses of biomedical materials field always.Hydroxyapatite intensity is higher, but degradation property is poor, and the bata-tricalcium phosphate degradation property is good, and intensity is lower, and is therefore that the two is compound, prepares with the composite diphase material of the two advantage to have the clinical use value of important medical.Traditional preparation hydroxyapatite and bata-tricalcium phosphate composite process are to prepare pure single-phase hydroxyapatite powder and bata-tricalcium phosphate powder at first respectively, by a certain percentage the two ball milling mixing, moulding, sintering are formed then.As " Wuhan Polytechnical Univ's journal " the 18th volume third phase 7-10 page or leaf of publication in 1996, exercise question has been reported the technology of this method for " being used for the development of hole, the TCP/HA Quito biological ceramics of big knochenbruch defect repair ".Its shortcoming is that bipolar mixture is inhomogeneous, the sintering temperature height, and the material biological activity that makes is low, and the back degradation property that implants is poor, is unfavorable for the reconstruction growth of the newborn bone of human body.
Summary of the invention
The objective of the invention is in order to overcome the above-mentioned traditional preparation hydroxyapatite and the weak point of bata-tricalcium phosphate diphase ceramic material method, the preparation method of a kind of hydroxyapatite and bata-tricalcium phosphate complex phase biological ceramics is proposed, employing adds bio-vitric in hydroxyapatite, make hydroxyapatite part in sintering process change bata-tricalcium phosphate into, thereby original position generate hydroxyapatite and bata-tricalcium phosphate complex phase biological ceramics.
Preparation method of the present invention may further comprise the steps:
(1) be 15～17% potassium oxide (K with weight percent (down together)
2O), 10～11% magnesium oxide (MgO), 10～12% magnesium fluoride (MgF
2), 50～53% silicon-dioxide (SiO
2), 3～5% zirconium dioxide (ZrO
2), 5～6% Vanadium Pentoxide in FLAKES (P
2O
5), 2～3% boron trioxide (B
2O
3) the raw material powder uniform mixing formed, dry-pressing formed after, in 1000～1100 ℃ of fusions, shrend, biological glass powder is made in ball mill pulverizing;
(2) with above-mentioned 5～15% (weight percent) biological glass powder, join in 85～95% hydroxy apatite powders, ball milling mixed 4～6 hours, was dry-pressing formed under 10～30 MPas at pressure;
(3) base substrate dry-pressing formed in the step (2) is carried out sintering under 1050～1250 ℃, obtain degradable hydroxyapatite and bata-tricalcium phosphate complex phase biological ceramics.
Characteristics of the present invention are:
Sintering temperature is low, has saved the operation of independent preparation bata-tricalcium phosphate and hydroxy apatite powder, has simplified preparation technology.
Prepared composite diphase material homogeneity and quality are guaranteed.
Prepared biological ceramics, its biological activity is good, is easy to degraded in vivo, and can obtains regulatable hydroxyapatite of bata-tricalcium phosphate content and bata-tricalcium phosphate complex phase biological ceramics as required, in order to the regulation and control degradation speed, help the reconstruction growth of the newborn bone of human body.
Hydroxyapatite that the present invention is prepared and bata-tricalcium phosphate complex phase biological ceramics are mainly used in damaged reparation of bone and bone tissue engineering stent material, also can use as the tooth dental repair material.
Embodiment
Embodiment 1
(1) be 15.2% potassium oxide (K with weight percent (down together)
2O), 10.8% magnesium oxide (MgO), 11.2% magnesium fluoride (MgF
2), 50.5% silicon-dioxide (SiO
2), 4.5% zirconium dioxide (ZrO
2), 5.2% Vanadium Pentoxide in FLAKES (P
2O
5), 2.6% boron trioxide (B
2O
3) the powder uniform mixing formed, dry-pressing formed after, in 1050 ℃ of fusions, shrend, ball mill pulverizing becomes biological glass powder again;
(2) with above-mentioned biological glass powder be 10% ratio by weight percentage, join in 90% hydroxy apatite powder that ball milling mixed 6 hours, was dry-pressing formed under 20 MPas at pressure;
(3) base substrate dry-pressing formed in the step (2) is carried out sintering under 1150 ℃, obtain the bata-tricalcium phosphate weight percent and be 60% degradable hydroxyapatite and bata-tricalcium phosphate complex phase biological ceramics.
Embodiment 2
(1) be 15.7% potassium oxide (K with weight percent (down together)
2O), 10.6% magnesium oxide (MgO), 10.5% magnesium fluoride (MgF
2), 51.3% silicon-dioxide (SiO
2), 4.3% zirconium dioxide (ZrO
2), 5.4% Vanadium Pentoxide in FLAKES (P
2O
5), 2.2% boron trioxide (B
2O
3) the powder uniform mixing formed, dry-pressing formed after, in 1080 ℃ of fusions, shrend, ball mill pulverizing becomes biological glass powder again;
(2) with above-mentioned biological glass powder 5% ratio by weight percentage, join in 95% hydroxy apatite powder, ball milling mixed 4 hours, was dry-pressing formed under 10 MPas at pressure;
(3) base substrate dry-pressing formed in the step (2) is carried out sintering under 1050 ℃, obtain the bata-tricalcium phosphate weight percent and be 40% degradable hydroxyapatite and bata-tricalcium phosphate complex phase biological ceramics.
Embodiment 3
(1) be 16.5% potassium oxide (K with weight percent (down together)
2O), 10.5% magnesium oxide (MgO), 10.2% magnesium fluoride (MgF
2), 51.8% silicon-dioxide (SiO
2), 3.2% zirconium dioxide (ZrO
2), 5.1% Vanadium Pentoxide in FLAKES (P
2O
5), 2.7% boron trioxide (B
2O
3) the powder uniform mixing formed, dry-pressing formed after, in 1100 ℃ of fusions, shrend, ball mill pulverizing becomes biological glass powder again;
(2) with above-mentioned biological glass powder weight percent be 15% ratio, join in 85% hydroxy apatite powder that ball milling mixed 5 hours, was dry-pressing formed under 30 MPas at pressure;
(3) base substrate dry-pressing formed in the step (2) is carried out sintering under 1250 ℃, obtain the bata-tricalcium phosphate weight percent and be 80% degradable hydroxyapatite and bata-tricalcium phosphate complex phase biological ceramics.
Claims (1)
1. one kind adds the method that bio-vitric prepares hydroxyapatite and bata-tricalcium phosphate complex phase ceramic, and its feature is taked following processing step:
(1) be 15～17% potassium oxide (K with weight percent (down together)
2O), 10～11% magnesium oxide (MgO), 10～12% magnesium fluoride (MgF
2), 50～53% silicon-dioxide (SiO
2), 3～5% zirconium dioxide (ZrO
2), 5～6% Vanadium Pentoxide in FLAKES (P
2O
5), 2～3% boron trioxide (B
2O
3) the raw material powder uniform mixing formed, dry-pressing formed after, in 1000～1100 ℃ of fusions, shrend, biological glass powder is made in ball mill pulverizing;
(2) with the ratio of above-mentioned biological glass powder in 5～15% (weight percents), join in the hydroxy apatite powder, ball milling mixed 4～6 hours, was dry-pressing formed under 10～30 MPas at pressure;
(3) base substrate dry-pressing formed in the step (2) is carried out sintering under 1050～1250 ℃, obtain controllable degradable hydroxyapatite of bata-tricalcium phosphate content and bata-tricalcium phosphate complex phase biological ceramics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410030651 CN1562873A (en) | 2004-04-02 | 2004-04-02 | Method for preparing bioceramic in complex phase of hydroxyapatite and beta triealcium phosphate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410030651 CN1562873A (en) | 2004-04-02 | 2004-04-02 | Method for preparing bioceramic in complex phase of hydroxyapatite and beta triealcium phosphate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1562873A true CN1562873A (en) | 2005-01-12 |
Family
ID=34481133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410030651 Pending CN1562873A (en) | 2004-04-02 | 2004-04-02 | Method for preparing bioceramic in complex phase of hydroxyapatite and beta triealcium phosphate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1562873A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323986C (en) * | 2006-03-20 | 2007-07-04 | 天津大学 | Method for preparing CaO-P2O5-MgO glass reinforced porous beta-tricalcium phosphate bioceramics |
| CN100340310C (en) * | 2005-05-08 | 2007-10-03 | 天津大学 | Preparation method of beta-TCP/11A composite biological material |
| CN103183507A (en) * | 2013-03-19 | 2013-07-03 | 徐州工业职业技术学院 | Preparation method of biphase calcium phosphate ceramic containing beta-calcium pyrophosphate |
| CN103341213A (en) * | 2013-06-25 | 2013-10-09 | 上海交通大学 | Preparation method for FHA/beta-TCP (fluorhydroxyapatite/beta-tertiary calcium phosphate) diphasic fluoridated hydroxyapatite 3D (three-dimensional) porous scaffold |
| CN108218382A (en) * | 2018-02-02 | 2018-06-29 | 付主枝 | The preparation method of degradable magnesium based composite metal bioceramic material |
| CN108245707A (en) * | 2018-01-24 | 2018-07-06 | 陕西科技大学 | A kind of preparation method of hydroxyapatite/bioglass material as Bone Defect Repari |
| CN108395236A (en) * | 2018-01-25 | 2018-08-14 | 合肥中科富华新材料有限公司 | A kind of preparation method and applications of bioceramic |
| CN115677368A (en) * | 2022-11-11 | 2023-02-03 | 广东欧文莱陶瓷有限公司 | Method for preparing high-strength ceramic tile by taking recycled waste as raw material |
-
2004
- 2004-04-02 CN CN 200410030651 patent/CN1562873A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100340310C (en) * | 2005-05-08 | 2007-10-03 | 天津大学 | Preparation method of beta-TCP/11A composite biological material |
| CN1323986C (en) * | 2006-03-20 | 2007-07-04 | 天津大学 | Method for preparing CaO-P2O5-MgO glass reinforced porous beta-tricalcium phosphate bioceramics |
| CN103183507A (en) * | 2013-03-19 | 2013-07-03 | 徐州工业职业技术学院 | Preparation method of biphase calcium phosphate ceramic containing beta-calcium pyrophosphate |
| CN103341213A (en) * | 2013-06-25 | 2013-10-09 | 上海交通大学 | Preparation method for FHA/beta-TCP (fluorhydroxyapatite/beta-tertiary calcium phosphate) diphasic fluoridated hydroxyapatite 3D (three-dimensional) porous scaffold |
| CN108245707A (en) * | 2018-01-24 | 2018-07-06 | 陕西科技大学 | A kind of preparation method of hydroxyapatite/bioglass material as Bone Defect Repari |
| CN108395236A (en) * | 2018-01-25 | 2018-08-14 | 合肥中科富华新材料有限公司 | A kind of preparation method and applications of bioceramic |
| CN108218382A (en) * | 2018-02-02 | 2018-06-29 | 付主枝 | The preparation method of degradable magnesium based composite metal bioceramic material |
| CN115677368A (en) * | 2022-11-11 | 2023-02-03 | 广东欧文莱陶瓷有限公司 | Method for preparing high-strength ceramic tile by taking recycled waste as raw material |
| CN115677368B (en) * | 2022-11-11 | 2023-04-25 | 广东欧文莱陶瓷有限公司 | Method for preparing high-strength ceramic tile by taking recycled waste as raw material |
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