CN1559529A

CN1559529A - Medicine for treating urticaria

Info

Publication number: CN1559529A
Application number: CNA2004100142494A
Authority: CN
Inventors: 郭士全
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-03-06
Filing date: 2004-03-06
Publication date: 2005-01-05
Anticipated expiration: 2024-03-06
Also published as: CN1242781C

Abstract

A Chinese medicine for treating urticaria is prepared from 15 Chinese-medicinal materials including schizonepeta, ledebouriella root, Chinese angelica root, liquorice root, etc.

Description

The urticarial medicine of a kind of treatment

Technical field

The invention relates to the urticarial Chinese medicine of treatment, is that a kind of pure compound Chinese medicinal preparation is treated urticarial medicine.

Background technology

Urticaria is commonly called as " wind pimple ", and " urticaria " is a kind of common anaphylactic disease.The doctor trained in Western medicine antiallergic agent can only be removed sensitizers such as histamine, eliminates allergic symptom, takes stopgap measures and does not effect a permanent cure, in case contact sensitinogen again, then can recur, and is if delay into chronic urticaria, then obstinate difficult.The treatment by Chinese herbs urticaria can be eliminated the irritated mechanism of body, and treating both the principal and secondary aspects of a disease eradicate urticaria and be difficult for recurrence, but except that the graduate urticaria ball of the traditional Chinese medical science, it is still rare specially to control urticarial Chinese patent medicine.Thereby having a curative effect height, relapse rate is low specially controls the urgent needs that urticarial Chinese patent medicine is present urticaria market.

Summary of the invention

Purpose of the present invention just provides a kind of elimination urticaria, short treating period, the urticarial medicine of the treatment that relapse rate is low, at urticaria sickness rate height, harm is big, Western medicine is cured the symptoms, not the disease, and the drawback that Chinese patent medicine is rare not only obviously improves curative effect, patient's misery can be more effectively removed, and patient's medical treatment cost can be reduced.

The scheme that solves its technical problem is: Herba Schizonepetae 1-14%, Radix Saposhnikoviae 1-14%, Gypsum Fibrosum 2-24%, Radix Rehmanniae 2-24%, Spica Prunellae 2-24%, Radix Scrophulariae 2-24%, Rhizoma Atractylodis 2-24%, Radix Sophorae Flavescentis 2-24%, Rhizoma Anemarrhenae 1-14%, Periostracum Cicadae 1-14%, Radix Angelicae Sinensis 1-14%, Fructus Arctii 1-14%, Caulis Akebiae 1-14%, Radix Arnebiae (Radix Lithospermi) 1-14% and Radix Glycyrrhizae 0.4-6%.

Above-mentioned Chinese medicine is mixed the back decocting, and grate goes out medicinal liquid and makes decoction; Perhaps make mixture, earlier as the decoction decocting taking liquid, add 95% ethanol, be made into 75% suspension, left standstill 24 hours, decontamination is purified, simmer down to 30ml, and autoclaving, it is anticorrosion to add sodium benzoate 0.3g, the sealing fill; Perhaps make electuary, after purifying as mixture earlier, evaporation is anhydrated, and the foam of getting it filled adds substrate system granule; Perhaps make tablet, after foam is got it filled in evaporation as electuary, add the substrate tabletting, pack after the sterilization; Perhaps make capsule, capsule conventional formulation method is made capsule.

Beneficial effect: adopt such scheme,, on the basis of knowing the urticaria etiology and pathogenesis clearly, utilize the Therapeutic Method of Chinese medical discrimination opinion, prepare the urticarial effective pure Chinese medicine medicine of a kind of treatment meticulously through big quantity research and clinical practice.Its major advantage is thoroughly to have known urticarial pathogenesis clearly, the dialectical key of having hited, so the curative effect height, short treating period is difficult for recurrence.Clinical verification, total effective rate reaches 93.64%.The course of treatment: acute measles 3-6 days, chronic urticaria 20-30 days.

Not only can satisfy the urticarial urgent needs of sociotherapy, and urticaria is reached radical cure not recur, and not need the fasting fish sensitization food such as to frighten more, can not only significantly improve clinical efficacy, and can make patient reduce medical treatment cost, reduce medical expense.So have vast market prospect, if can develop, will obtain good economic benefit and social benefit.

The specific embodiment

Embodiment 1: the treatment urticaria drug: Herba Schizonepetae 10 grams, Radix Saposhnikoviae 10 grams, Gypsum Fibrosum 30 grams, the Radix Rehmanniae 30 grams, Spica Prunellae 30 grams, Radix Scrophulariae 30 grams, Rhizoma Atractylodis 30 grams, Radix Sophorae Flavescentis 30 grams, the Rhizoma Anemarrhenae 10 grams, Periostracum Cicadae 10 grams, Radix Angelicae Sinensis 12 grams, Fructus Arctii 10 grams, Caulis Akebiae 6 grams, Radix Arnebiae (Radix Lithospermi) 12 grams, Radix Glycyrrhizae 6 grams.Be daily dose;

Make decoction, be decocted in water for oral dose, 1 dose of day, divide clothes 2 times.Anxious collection urticaria 3-6 agent was 1 course of treatment, and chronic urticaria 20-40 agent was 1 course of treatment.

Clinical effectiveness is observed: urticaria is clinical common refractory disease, utilizes urticaria soup treatment urticaria 110 examples, and matched group 60 examples, is reported as follows.

1. clinical data

Selection meets Wu Zhihua chief editor " skin cypridology " ^[1]Urticaria patient's 170 examples of relevant urticaria diagnostic criteria are divided into two groups, and 110 examples are organized in treatment, male 49 examples, and women 61 examples, in age 6-72 year, average 33.2 ± 11.3 years old, the course of disease was the shortest 3 days, and is the longest 16 years, average 283.7 ± 16.7 days.Acute 78 examples, 32 examples.Matched group 60 examples, in age 7-56 year, average 28.7 ± 8.4 years old, the course of disease was the shortest 3 days, and is the longest 20 years, average 207.5 ± 17.9 days.Acute 42 examples, chronic 18 examples.

2. Therapeutic Method decoction: be decocted in water for oral dose, day 1 dose, divide clothes 2 times.

Treatment group urticaria soup: Herba Schizonepetae 10 grams, Radix Saposhnikoviae 10 grams, Gypsum Fibrosum 30 grams, the Radix Rehmanniae 30 grams, Spica Prunellae 30 grams, Radix Scrophulariae 30 grams, Rhizoma Atractylodis 30 grams, Radix Sophorae Flavescentis 30 grams, the Rhizoma Anemarrhenae 10 grams, Periostracum Cicadae 10 grams, Radix Angelicae Sinensis 12 grams, Fructus Arctii 10 grams, Caulis Akebiae 6 grams, Radix Arnebiae (Radix Lithospermi) 12 grams, Radix Glycyrrhizae 6 grams.Be daily dose; 1 dose of day, divide clothes 2 times.3-6 days observe the curative effect of acute urticaria clothes.1 month observe the curative effect of chronic urticaria clothes.

Matched group hismanal 10mg/ time, 1 time/day, plug pyridine in heptan 2mg/ time, 2 times/day.3-6 days observe the curative effect of acute urticaria clothes.1 month observe the curative effect of chronic urticaria clothes.

Two groups are all finished later six months and 1 year the course of treatment and respectively follow up a case by regular visits to 1 time.

Table 1. liang group curative effect is (example) relatively

Cure enabledisable total effective rate (%) x ²P

Treatment organizes acute 59 18 1 98.72 16.15＜0.005

Chronic 18 86 81. 25 3.25＞0.05

Add up to 77 26 7 93.64 19.15＜0.005

Matched group acute 13 18 11 73.81

Chronic 468 55.56

Add up to 7 24 19 68.33

3. criterion of therapeutical effect and therapeutic outcome

Criterion of therapeutical effect is with reference to factitial urticaria such as Li Yuanwen treatment standard.Cure: erythra disappears fully, and pruritus disappears, and follows up a case by regular visits to 1 year person of not sending out.Effectively: deflorescence, pruritus disappear, and 1 is only and sends out 1 time, and the clothes top is the responder still.Invalid: erythra has to disappear or do not have and disappears, and pruritus alleviates or do not have and alleviates, recurrence person more than 2 times in 1 year.Two groups of curative effects such as tables 1.By table 1 as seen, treatment group curative effect obviously is better than matched group (P＜0.005), and especially the effect of acute urticaria is good (P＜0.005) than matched group.

Urticaria belongs to sick category such as the traditional Chinese medical science " rubella ", " eczema " " angioneurotic edema ", and the pathogenesis that gets to the bottom of sb.'s illness is mainly due to innate deficiency, the heresy that affection of exogenous wind-cold is damp and hot, cohesion flesh table, or improper diet, the product that the surfeit smelling of fish or mutton is pungent, help humidogene heat, lead to pyretic toxicity, interior must not be saturating, must not send out outward, cause stagnation of QI-blood, generate rubella wheal.Manyly in the past controlled from the wind heat opinion, many with dispersing the product of letting out clearly, and ignore the damp eliminating blood stasis dispelling, thus can not speed heal, and be easy to recur.Because of though wind benefaction number becomes, be easy to speed and dispel, in a single day right fighting with wetting phase, then touching difficulty more is difficult for eradicating.Damp is kind again checks mechanism of qi, and the heat of skin can not be sent out thoroughly, and stagnation of QI-blood is difficult for speed more.Event must dispersed on the basis of wind heat, holds concurrently with damp eliminating, and cooling blood and removing stasis, the stasis of blood is logical can speed to heal, and wets and dispels and can eradicate.So the present invention uses Herba Schizonepetae, Radix Saposhnikoviae, Periostracum Cicadae, Fructus Arctii earlier, dispelling exopathogens from superficies of the body, make pathogenic heat send out thoroughly in outside, Gypsum Fibrosum, the Rhizoma Anemarrhenae, clearing away heat-fire is with strongly fragrant pyretic toxicity in rushing down.Add Spica Prunellae, Rhizoma Atractylodis, Radix Sophorae Flavescentis, Caulis Akebiae again on this basis, heat clearing and damp drying, the Radix Rehmanniae, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Sinensis, the cooling blood and removing stasis rash, double getting controlled the meaning that wind is controlled blood earlier.All medicines share, and interior-heat is clear, and exterior heat is loose, and wet blood stasis dispelling is logical, and measles toxin is passed through inside, so the merit of receiving.

Embodiment 2: the prescription with embodiment 1 is made mixture, earlier as the decoction decocting taking liquid, adds 95% ethanol, is made into 75% suspension, leaves standstill 24 hours, and decontamination is purified, simmer down to 30ml, and autoclaving, it is anticorrosion to add sodium benzoate 0.3g, the sealing fill.3 times/day, 10ml/ time, other and embodiment 1 omit together.

Embodiment 3: the prescription with embodiment 1 is made electuary, and after purifying as mixture earlier, evaporation is anhydrated, and the foam of getting it filled adds substrate system granule, makes 3 bags, and 3 times/day, 1 bag/time; Other and embodiment 1 omit together.

Embodiment 4: the prescription with embodiment 1 is made tablet, after foam is got it filled in evaporation as electuary, adds the substrate tabletting, makes 12 altogether, pack after the sterilization, and 3 times/day, the 2-4 sheet/time.Other and embodiment 1 omit together.

Embodiment 5: the prescription with embodiment 1 is made capsule, and capsule conventional formulation method is made capsule, divides clothes every day 3 times, and other and embodiment 1 omit together.

Claims

1, the urticarial medicine of a kind of treatment is characterized in that: Herba Schizonepetae 1-14%, Radix Saposhnikoviae 1-14%, Gypsum Fibrosum 2-24%, Radix Rehmanniae 2-24%, Spica Prunellae 2-24%, Radix Scrophulariae 2-24%, Rhizoma Atractylodis 2-24%, Radix Sophorae Flavescentis 2-24%, Rhizoma Anemarrhenae 1-14%, Periostracum Cicadae 1-14%, Radix Angelicae Sinensis 1-14%, Fructus Arctii 1-14%, Caulis Akebiae 1-14%, Radix Arnebiae (Radix Lithospermi) 1-14% and Radix Glycyrrhizae 0.4-6%;

Above-mentioned Chinese medicine is mixed the back decocting, and grate goes out medicinal liquid and makes decoction; Perhaps make mixture, earlier as the decoction decocting taking liquid, add 95% ethanol, be made into 75% suspension, left standstill 24 hours, decontamination is purified, simmer down to 30ml, and autoclaving, it is anticorrosion to add sodium benzoate 0.3 g, the sealing fill; Perhaps make electuary, after purifying as mixture earlier, evaporation is anhydrated, and the foam of getting it filled adds substrate system granule; Perhaps make tablet, after foam is got it filled in evaporation as electuary, add the substrate tabletting, pack after the sterilization; Perhaps make capsule, capsule conventional formulation method is made capsule.