CN1558784A - Endotracheal tube with tip directional control and position preserving mechanism - Google Patents

Endotracheal tube with tip directional control and position preserving mechanism Download PDF

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Publication number
CN1558784A
CN1558784A CNA018238270A CN01823827A CN1558784A CN 1558784 A CN1558784 A CN 1558784A CN A018238270 A CNA018238270 A CN A018238270A CN 01823827 A CN01823827 A CN 01823827A CN 1558784 A CN1558784 A CN 1558784A
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CN
China
Prior art keywords
conduit
flexible portion
equipment
far
equipment according
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Granted
Application number
CNA018238270A
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Chinese (zh)
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CN100352520C (en
Inventor
����³��J���е�
安德鲁·J·托蒂
H
迈克尔·H·王
杰伊·科汀
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MERLYN ASSOCIATES Inc
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MERLYN ASSOCIATES Inc
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Priority claimed from PCT/US2001/044296 external-priority patent/WO2003045485A1/en
Publication of CN1558784A publication Critical patent/CN1558784A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0402Special features for tracheal tubes not otherwise provided for
    • A61M16/0418Special features for tracheal tubes not otherwise provided for with integrated means for changing the degree of curvature, e.g. for easy intubation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0434Cuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/01Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes specially adapted for anaesthetising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816Joints or connectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0133Tip steering devices

Abstract

An endotracheal (10) tube which facilitates rapid intubation of the trachea, especially in situations where anatomical variation creates difficult intubating conditions, includes a portion that can be bent (34) during placement to control the position of the distal end (16) of the tube (10). The distal end (16) of the endotracheal tube (10) may be selectively curled or bent by a mechanism or fluid passage accessible from the proximal end (20) of the endotracheal tube (10). The endotracheal tube (10) provides for manipulation of the insertion end without occluding the lumen of the tube (10), to facilitate placement of the tube (10).

Description

Endotracheal tube with end direction control and orientation maintaining means
Technical field
Present invention relates in general to a kind of endotracheal tube.More particularly, the present invention relates to a kind of have be designed to be easy to owing to anatomical structure variation, wound, and the like the caused endotracheal tube that is not easy to make the flexible portion that place that airway (air pipe inlet) inserts inserts airway of reason.
Background technology
Endotracheal tube comprises generally as gas passage, so that oxygen and anesthetic gases are directly supplied with patient's cylindrical conduit.Cylindrical conduit is beneficial to the open distal end of inserting conduit by the end of being formed with always, and it has the opening opposing near-end that formation can be connected with source of the gas.Typical endotracheal tube has inflatable band to be used to form the sealing with the outer wall of conduit in the outside of cylindrical conduit.(referring to the U.S. Patent number No.3 of Doherty, 460,541).Band is used for occlusion catheter, and it can protect trachea and pulmonary to avoid sucking impurity.Specifically, the material that can prevent food, impurity or digestive system enters pulmonary.Endotracheal tube is mainly used in surgical operation, simultaneously also through being usually used in the occasion of emergency room and Emergency Assistance.
In needing the surgical procedures of general anesthesia, owing to comprise the narcotic effect of anesthetics and/or anesthetic gases, patient always is in automatism.Patient's is of flaccid muscles simultaneously/and stiff, thus reduce patient to inserting the disgusting reaction that endotracheal tube produces.Laryngoscope is placed on patient's mouth.The blade of laryngoscope is used for side and promotes tongue, and the intubate operator applies power upwards for the laryngoscope handle, so that can see the anatomical structure of oral cavity and trachea.The concrete target area of endotracheal tube is a glottis, just the space between vocal cords and the air pipe inlet.The far-end of endotracheal tube inserts glottis, and is full of air in the inflatable band (air bag), thereby forms gas-tight seal between band wall and inner surface of trachea.Gas-tight seal can make oxygen and anesthetic gases directly be sent to be arranged in the gas passage below far-end and the air bag under the effect of normal pressure.
Patient's anatomical structure is very different, and can it be grouped into different classifications according to the intubate difficulty that may exist.The patient of glottis or target hole before having (vocal cords and the space of the higher position that is arranged in patient's neck) to the cervical region front, the insertion end of placing endotracheal tube by the gap may be very difficult, and possible, even occur dead owing to anoxia causes grievous injury.Though the careful assessment that anesthesiology expert or health care operator propose thinks very difficult, some situation still is unpredictable arriving, unless can see tracheal orifice and vocal cords clearly by laryngoscope and blade apparatus.When this happens, the operator must take away laryngoscope, the probe (stylette) (semirigid stilet) of metal or plastics is inserted the inner chamber of endotracheal tube, conduit and probe are bent to suitable shape, thereby help insertion end is placed on appropriate position, and as positioning and guiding.Similar to the shape of hockey stick, probe and endotracheal tube are carried out very little bending, the main body of endotracheal tube is remained unchanged.In case finished this work, another part thing that the operator will do is observed vocal cords and inlet exactly.The curved shape of insertion end helps increasing the chance of insertion end being passed tracheal orifice.For example, at the U.S. Patent number No.2 of Sanders, the early stage endotracheal tube that comprises deflectable stylet is illustrated in 458,305.
Though the method that adopts probe to be used for the insertion end of crooked endotracheal tube is extensive use of, this method also has many shortcomings.Guiding-tube bend is become appropriate shape, observe subsequently and insert passage, and then from the inner chamber of endotracheal tube, take away these steps a lot of valuable time of meeting waste in finishing the process of intubate of probe.For irrespirable unconscious patient, the time is the most valuable, particularly when filling thing in patient's the stomach, will increase the chance that sucks impurity.
Equally, after the trial step of having finished initial placement laryngoscope, always to use probe usually.In addition, because the probe that will use must be semirigid, can be easy to bending, in case crooked, shape also can keep.The damage that this inherent characteristic makes patient to cause in trachea owing to probe is in danger, and trachea also has hemorrhage possibility simultaneously.In the past, adopt probe may cause the damage of soft tissue perforation and vocal cords.
Also do not have in the existing apparatus successfully to realize so that endotracheal tube forms suitable shape, thereby successfully patient to be carried out intubate by abandoning using probe.
Now existing devices are designed to help endotracheal tube is placed in the target hole.For example, now be developed into and can have helped the laryngoscope that inserts.Yet these devices can not provide the mechanism of the flexibility that can control the insertion end of endotracheal tube own.
The U.S. Patent No. 4,685,457 of the U.S. Patent No. 4,589,410 of Miller, the U.S. Patent No. 4,150,676 of Jackson and Donenfeld respectively demonstrates along having at least one draught line on the wall of the length of conduit part.Obviously, because the compression of material structure applies tension force and causes in the conduit generation near the balloon positions place curling on draught line.Yet the end of conduit can be not crooked, and bending is distributed in along on the whole length of backguy.These devices do not use the catheter wall of hinge or spring type mechanism or distortion, equally do not adopt retaining mechanism yet.As a result, these existing apparatus can not make the end of conduit selectively move.In these existing apparatus, by can the most pulley mechanism of bending conduit, the main body of conduit can move, therefore because conduit moving in the oral cavity also can produce some problems.
Utilization comprises the U.S. Patent No. 5 of Umeda, 255,688 other devices in interior guiding-tube bend mechanism can be directly connected to the bendable endoscope that is used for bronchoscopy (bronchoscopy), the crooked end that it is included between two coils on the catheter wall can cause the sweep bending by the draught line on the pull catheter wall.The U.S. Patent No. 4 of Sosnowski, 911,148 can directly link to each other with minor diameter endoscope (diameter of 0.15mm or littler), and it is along having a series of radial slots that certain intervals is arranged on the length direction of conduit, and draught line passes the catheter wall of otch.During the draught line tension, cause that the conduit edge has the part bending of otch, thereby can cause the far-end bending.The U.S. Patent No. 5,304,131 of Paskar shows tremulous pulse or the venous duct that has along the weakening part of conduit one side.Weakening part is owing to the otch that passes catheter wall causes.The cable of the wall by being passed in otch one side can make the weakening part bending.In order to help to make weakening part recover original rectilinearity, weakening part can surround with spring, thereby can seal weakening part, and pipe box can cover spring and weakening part.
The U.S. Patent No. 4,353,358 of Emerson links to each other with softish S sigmoidoscope, and it has otch and the draught line similar to the patent of Sosnowski et al.Heimberger has shown the endoscope and the conduit of the flexible far-end that other has hinge fraction and draught line equally in the U.S. Patent No. 5,772,578 of et al and the U.S. Patent No. 5,448,989 of Heckele.The U.S. Patent No. 5,306,245 of Heaven has shown flexible tube, and it comprises the cut wall relative with the flexible rustless steel hinge with the draught line on the conduit wall of relative hinge.The part of dissecing to the major general is covered by the plastic material of outside.Vinyl cover equally also can cover draught line, also can cover the whole length of conduit simultaneously.Air bag can be added in the end of flexible portion.These devices do not comprise such as inaccessible air bag required in endotracheal tube.Though comprise an air bag in the patent of Heaven, it is in the end of flexible portion, and is used for cholangiography, is not for sealing duct.
These devices are not to operate in the mode of endotracheal tube in aforementioned two paragraphs.They can not be in conjunction with feature of the present invention, when the major part of conduit keeps its original shape, connects with the joint near the part of the conduit of insertion end.
Though endotracheal tube has had multiple change, innovation and development, but need can be only at the device of end bent, and have can temporary locking position mechanism.Such endotracheal tube will be vacateed another hand operated other device such as laryngoscope with a hand operated conduit easily.Equally, also can under the assistance that does not have lumen catheter, finish the work.
Summary of the invention
Endotracheal tube of the present invention has the far-end of being arranged to be inserted in the person's windpipe that can handle, and it does not need to adopt probe or other guiding device, but the end of conduit can be near glottis.Leading body keeps its original shape, but can make end of conduit distortion or crooked separately, and in the process of placing endotracheal tube, can remain on the desired position always.In the process of far-end bending, the inner chamber of endotracheal tube keeps clear, thereby can not block patient's trachea.Belong to the various designs of volume scope of the present invention by employing, combine, can make the far-end of conduit form required far-end curvature with one or more mechanisms that are used for the far-end of control lead.According to the specific embodiment that the present invention is exemplary, it comprises:
1) setting spring between far-end and leading body;
2) adopt ultrasound wave, heat, solvent processing or similar method,, thereby can increase the flexibility of this part so that change the molecular structure or the composition of the polymer of the part that forms the conduit of wanting crooked;
3) between far-end and leading body, adopt polymeric separator plates;
4) surround the part of wanting crooked with polymer springs; Or
5) between far-end that is with or without the support spring and leading body, provide zone thin, that otch or incision are arranged.
Above-mentioned all mechanisms can be applied to the outside of endotracheal tube, are combined in the wall of conduit, or are inserted in the inner chamber of conduit.Endotracheal tube of the present invention can design one equally and be applied to the controlling organization that is used to cause the mobile and temporary transient locking bending of end on the distal catheter.By adopting friction locking unit, single shaft locking, slide lock device, brakes or can realizing this function to the similar locking device of draught line co-operate with lock ring.This locked position allows the operator to have at least a hands to have time can handle other device.In it was preferably operated, one held endotracheal tube, used another manual operating laryngoscope simultaneously.After the curved end of conduit was inserted on its desired position, trigger mechanism was disengaged at an easy rate, and conduit can present its original shape.Preferably, be inaccessible conduit cavity to occur in conjunction with the endotracheal tube of feature of the present invention, thereby make the operator can carry out far-end control capitally, and realize trachea control fast.
Description of drawings
To explanation of the present invention, claims and accompanying drawing, above-mentioned and/or others of the present invention and advantage will obtain more clearly understanding with reference to accompanying drawing.Wherein:
Fig. 1 is the part cut away view in conjunction with the endotracheal tube of feature of the present invention;
Figure 1A is the amplification cut away view of air bag shown in Figure 1;
Fig. 2 is the part cut away view of the endotracheal tube of far-end Fig. 1 of being in case of bending;
Fig. 3 is that the part of far-end of endotracheal tube of Fig. 2 of the sweep of display device is amplified cut away view;
Fig. 4 is that the part that is presented at the endotracheal tube of Fig. 2 that the apparatus control portion on the far-end retrieving position divides is amplified cut away view;
Fig. 5 is the end view drawing along the near-end of the demonstration endotracheal tube of the intercepting of the line 5-5 among Fig. 4;
Fig. 6 is that the part in conjunction with the far-end of second specific embodiment of the endotracheal tube of feature of the present invention of display device sweep is amplified cut away view;
Fig. 7 is that the part of far-end of endotracheal tube of Fig. 6 that is presented at the device sweep of its curved shape is amplified cut away view;
Fig. 8 is that the part in conjunction with the far-end of the 3rd specific embodiment of the endotracheal tube of feature of the present invention of display device sweep is amplified cut away view;
Fig. 9 is that the part of far-end of endotracheal tube of Fig. 8 that is presented at the device sweep of its curved shape is amplified cut away view;
The part in conjunction with the far-end of the 4th specific embodiment of the endotracheal tube of feature of the present invention of Figure 10 display device sweep is amplified cut away view;
Figure 11 is the sectional view along the intercepting of the line 11-11 among Figure 10;
Figure 12 is the side view according to the near-end of the endotracheal tube of the 5th specific embodiment of the present invention;
Figure 13 shows the top view of the near-end of endotracheal tube as shown in figure 12;
Figure 14 is the side view of the near-end of the endotracheal tube of the 6th specific embodiment according to the present invention;
Figure 15 shows the top view of the near-end of endotracheal tube as shown in figure 14;
Figure 16 is the side view of the endotracheal tube of the 7th specific embodiment according to the present invention;
The sectional view of the endotracheal tube of Figure 16 of Figure 17 17-17 intercepting along the line;
Figure 18 is the side view of a part of endotracheal tube that shows Figure 16 of its some details;
Figure 19 and 19A are sectional view and the side views that comprises the part of the endotracheal tube of the 8th specific embodiment according to the present invention respectively;
Figure 20 and 20A are sectional view and the side views that comprises the part of the endotracheal tube of the 9th specific embodiment according to the present invention respectively;
Figure 21 and 22 is the near-ends that show the endotracheal tube of the tenth specific embodiment according to the present invention respectively, is in the side view of crooked and unbent shape at it;
Figure 23 and 24 is the near-ends that show the endotracheal tube of the 11 specific embodiment according to the present invention respectively, is in the side view of crooked and unbent shape at it;
Figure 25 is the perspective view of flexible membrane of the specific embodiment of a pair of Figure 23 of being used for and 24;
Figure 26 is the right perspective view of flexible membrane that is presented at the Figure 25 in its nested or package assembly;
Figure 27 and 28 is respectively the enlarged side view of the near-end of the endotracheal tube in Figure 23 and 24;
Figure 29 and 30 is the near-ends that show the endotracheal tube of the 12 specific embodiment according to the present invention respectively, is in the side view of crooked and unbent shape at it;
Figure 31 A is the side view with endotracheal tube of the inflated type band of using film alternate figures 1;
Figure 31 B is the longitdinal cross-section diagram along the endotracheal tube of the intercepting of the line 31B-31B among Figure 31 A;
Figure 32 has the cable that the pulls back side view in order to the endotracheal tube of Figure 31 A of forming guiding-tube bend;
Figure 33 is the side view that shows the specific embodiment of the invention of utilizing a plurality of otch; And
Figure 34 is the side view with endotracheal tube of band far-end otch.
The specific embodiment
Fig. 1 to 5 shows in conjunction with the endotracheal tube 10 of first specific embodiment of feature of the present invention, also can select to be called endotracheal tube.Endotracheal tube 10 has tubular body 12, and it has the inflatable airbag 14 that also can be described as band, and inflatable airbag is installed on the outer surface near the tubular body 12 of the far-end 16 of endotracheal tube.Conduit 18 is connected with space between tubular body 12 and the inflatable airbag 14, or links to each other with the injection section of band in many walls air bag.Conduit 18 extends to the far-end 16 of tubular body 12 always from the near-end 20 of tubular body 12.In case tubular body 12 is placed in the patient's trachea on its desired position, just can makes air bag 14 be inflated to required inaccessible diameter with conduit 18.Conduit 18 is typical small diameter catheter 22, and it is passed in the passage 24 in the wall 26 of tubular body 12, or extends along the interior or outer surface of wall 26.Selectively be, the passage 24 in wall 26 can constitute conduit 18, and minor diameter tubulose main body 12 is enclosed the near-end of passage 24.The near-end of small diameter catheter 22 is provided with valve 28, and it is used for maintaining the inflation air of air bag 14, and typically, when band 14 from trachea when further expansion meets obstructions, guide gasbag 30 can continue to make its inflation.Demonstrate the band 14 with diameter bigger than the external diameter of tubular body 12 among the figure, shown band 14 and the shape of guide gasbag 30 after it emits gas among the figure too, when inflation, band and air bag can also further increase.
Be adapter 32 on the near-end 20 of tubular body 12, it is used to connect endotracheal tube 10 to air, oxygen or gas anesthesia intermixture source such as respiratory organ or wall dress air feeder (not shown).The far-end 16 of tubular body 12 is opened, and can allow gas to enter pipe flow and do not block patient's trachea.In Fig. 1, far-end 16 demonstrates selectable tip designs, and it comprises two side openings and protection top, shows the level and smooth leading surface with respect to the tissue of gas passage like this, thereby in the process of placing endotracheal tube 10, can reduce the damage of organ-tissue.
Endotracheal tube 10 is included on the wall of tubular body 12, and be inflated flexible portion 34 that formula air bag band 14 covers, extend to the cable 36 of far-end 16 from the near-end 20 of tubular body 12, and the controlling organization 38 that is installed in the near-end of cable 36.In first specific embodiment of the present invention,, can form flexible portion 34 by removing band 14 below the part of wall 26 and whole in the zone.Shown in the specific embodiment of Fig. 6 to 7, if the part of wall keeps, reserve part 40 is along the side of tubular body 12, and is relative with the position of cable 36.Reserve part 40 can be crooked as hinge.In first specific embodiment of the present invention, helical spring 42 is positioned at the flexible portion 34 of tubular body 12, provides a supporting and globality for flexible portion 34, in case and the deformation force releasing, it can make bending conduit return to its original shape.
The part of conduit wall 26 is removed, shown in Figure 1A, provided independently band 14.The gas compartment in the band is isolated with the air-flow that flows through endotracheal tube 10 fully like this.So independently band 14 has the expansible adventitia 70 of relative trachea, and towards the inner membrance 72 of trachea wall opening part.End 74 is used for the outer surface sealing of band 14 with tubular body 12.Conduit 18 is used for to band 14 inflations.
Best as shown in Figure 4, cable 36 passes the hole 44 near the wall 26 of the tubular body 12 the near-end 20 of tubular body 12.Cable 36 can pass from the inner chamber of tubular body 12, or is passed in second channel 46 on the wall of tubular body 12 near band 14, and it passes wall 26 and is withdrawn in the space 48 that is surrounded by band 14 at there.Then, the far-end 50 of cable 36 is installed on the wall 26 of tubular body 12 at point 52 places away from the exit, but still in space 48.Can install by binding agent, clip, ring or other adhering apparatus or in the well-known technology in this field.Cable 36 can be formed by various materials.For example, can be the thin cable with stainless steel silk such as piano string or operation, the plastics silk thread such as nylon monofilament, multifilament braiding structure or stitching thread, or other is as other various materials of stitching thread or tension ropes.
Handle or trigger 54 are installed on the near-end 20 of tubular body 12, and it can vertically move (referring to Figure 4 and 5) on slideway 56.The near-end of cable 36 is installed on the trigger 54, pressing when regaining trigger 54 on the direction shown in the arrow of Fig. 1 as the operator like this, pull strength is sent on the banded remote point 52 of cable, cause that tubular body 12 is crooked in the zone that band 14 covers, and shown in Fig. 2 and 3, cause spring 42 bendings.When trigger was removed, spring 42 can make tubular body 12 get back to as shown in Figure 1 not curved shape.Trigger 54 and slideway 56 can form certain size, have enough frictions between these elements so that trigger 54 can be remained on the position of its withdrawal like this.
Fig. 6 and 7 demonstrates the change form to first specific embodiment, wherein extensible but can not be covered with flexible portion 34 by expansible film 58 in fact, thereby the inner chamber and the spring 42 of cable 36 and tubular body 12 are separated, and prevented that flowing through gas from tubular body 12 produces expansion or pulsating force at band 14.In this example, film 58 is as the inner membrance 72 of the band among Figure 1A 14, and cable passes band 14 and do not pass between air bag inner membrance 72 and the spring 42.In addition, Fig. 6 and 7 described change forms and first specific embodiment realize its function in the same manner.
Fig. 8 and 9 shows another specific embodiment, wherein provides one or more otch 60 in the wall 26 that has as the bottom 62 of the otch 60 of hinge, thereby forms flexible portion 34.This specific embodiment does not have to show the use to spring 42, and identical with preceding described purpose, spring can be used in the part of conduit.Show that also membrane 58 is covered with the inner membrance 72 of otch 60 and formation band 14.
Figure 10 shows cut away view, and Figure 11 show endotracheal tube of the present invention the optional specific embodiment have an end view drawing that covers the far-end of spring 42 with film 58.
Figure 12 and 13 shows that it comprises and is used for handle or trigger 82 are remained on the locational mechanism 80 that it is regained fully according to the 5th specific embodiment of the present invention.The Figure 12 and 13 the specific embodiment comprise the general connector 84 that the near-end by tubular body 12 holds.Handle or trigger are installed on the cable 86, and as previously mentioned bright, can move in the slideway 88 of longitudinal extension, thereby make far-end 90 bendings of tubular body 12.Shown in Figure 12 and 13, when trigger is on the position that it is regained fully, a pair of have to hold with the compliant retainer 94 and 96 of the longitudinal extension of the relative notch 98 of fixing trigger 82 and 100 be installed on the near-end 92 of endotracheal tube 12.As previously mentioned, this maintaining body can allow with a manual operating trigger.
Figure 14 and 15 shows the 6th specific embodiment of the present invention, and it comprises the fixedly maintaining body of selecting that is used for trigger 82 is fixed in its complete retrieving position.In this specific embodiment, the hook 110 that rotates around vertical shaft 112 can move between the position of pinning and unclamping.On locked position, shown in Figure 14 and 15, hook 110 can be fixed on the position that it is regained fully with trigger 82.As shown in figure 15, when hook 110 clockwise rotated, trigger was removed.
Figure 16 to 18 shows the 7th specific embodiment of the present invention.It comprises a bending, have certain inflexible draw runner or the flat tinsel of stretching 120, so that drive flexible far-end 122.Just in time shown in Figure 17 and 18, draw runner or tinsel 120 are slidably disposed on and are formed in the longitudinal extension groove or raceway groove 124 in the wall of endotracheal tube 12.Be used to drive far-end between its bending and unbent shape at the hook 126 on the near-end of draw runner or tinsel 120.
Figure 19 to 19A shows the 8th specific embodiment of the present invention, wherein without the single cable curved distal end, with a pair of cable 130 in the passage 134 and 136 in the wall 138 that is arranged on endotracheal tube 12 and 132 distortion or crooked far-end on the direction of one of edge Y-axis two directions as shown in figure 19.Selectable structure is shown in the 9th specific embodiment of the present invention as shown in figure 20, can have more multiformity.In this case, be arranged on four cables 140,142,144 and 146 in passage 148,150,152 and 154 90 ° of each intervals in the wall 156 of endotracheal tube 12, be used in along curved distal end on X-axis, Y-axis or any direction between this, thereby provide maximum selectable angles, so that control the bending direction of far-end more accurately.
Figure 21 and 22 shows the tenth specific embodiment of the present invention, wherein provides flexible can for the far-end of endotracheal tube by the corrugated tube part 160 in band 162.The corrugated tube part of this flexibility can make far-end move in any direction, does not need any additional covering can keep the airtight integrity of conduit simultaneously.Comprise the little air lock 164 that below the corrugated tube part 160 of the far-end of endotracheal tube, is provided with in the Figure 21 and 22 the specific embodiment.The air of making a forcible entry into this chamber by small diameter catheter 166 can cause the little air lock 164 relative fixedly protruding parts 168 that extend below corrugated tube part 160 to expand with air-flow.Figure 22 shows the far-end of this specific embodiment, because the curved shape of pressure when air or other air-flow are introduced little air lock 164.
Figure 23 to 28 shows the 11 specific embodiment of the present invention.In this specific embodiment, the v-notch 170 below the far-end that is formed at endotracheal tube 12 can provide the flexibility of far-end.This V-type tangent plane or otch 170 are covered by duplex film, and Figure 25 and 26 has provided detailed explanation.The first flexible inner membrance 172 that comprises transversal fold 174 is designed to be enclosed within the similar outer flexible membrane 176.Outer flexible membrane 176 equally also comprises the gauffer 178 of horizontally set.These gauffers can make film expand.Various films bond together along its edge 180 and 182, thereby limit the space 184 of sealing between it.Air under pressure or air communication are crossed small diameter catheter 186 and are supplied to this space.The far-end of endotracheal tube that Figure 27 and 28 shows these specific embodiment is crooked and curved shape not at it, and when air or other air-flow are made a forcible entry into space 184 between inside and outside film, the bending of far-end or the shape of warpage.
Figure 29 and 30 shows the 12 specific embodiment of the present invention, and it comprises foregoing endotracheal tube with the far-end that comprises band.V-type tangent plane or otch 190 are formed in the far-end of the endotracheal tube 12 in band 14 scopes.Swelling gasbag 192 with utmost point far-end 194 and utmost point near-end 196 is inserted into the lower end of v-notch 190.When utmost point near-end held the far-end of small diameter catheter 198, utmost point far-end 194 sealed.The far-end of conduit 198 bonds with fluid-tight fashion or is fixed in the utmost point near-end 196 of air bag.And as shown in figure 30, air or other fluid of making a forcible entry into air bag cause that it expands, thereby cause the far-end bending of endotracheal tube.
The specific embodiment of Figure 21 to 30 shows the small diameter catheter 166,186 and 198 that is used for air or the supply of other fluid air lock 164, duplex film 172,176 and air bag 192.Illustrated in the small diameter catheter that goes out together reach the outside of main tubular body.Yet small diameter catheter equally also can reach the inside of main tubular body.Selectively be that and in the similar mode of conduit 18 as shown in Figure 1, small diameter catheter can be extended in the channel interior in the wall of main tubular body.Similarly, when small diameter catheter was enclosed the near-end of passage, self can constitute the small diameter catheter of airtight or liquid seal the passage in wall.
Though, the present invention has been carried out extremely explaining with reference to some preferred embodiment.But the present invention also has the imagination of some others.For example, do not need destination and provide flexible portion, do not need the far-end of cable is placed between the outer wall of band and conduit yet to wall.Flecition can obtain by the band type endotracheal tube that employing has a standard of the cable that passes conduit cavity or catheter wall.Then, cable can pass from the wall near band just, and just is connected on the wall of band far-end the outside of band (promptly).Spur cable in aforesaid mode and cause that conduit is crooked by the zone that band covers.
In addition, do not need flexible portion 34 is defined in the band zone.By making cable pass catheter wall before required sweep, and the near-end of cable is connected thereto, any part of conduit can cause bending.The pulling cable can make that part of guiding-tube bend of cable in the outside of conduit.
Other change in the general field of above-mentioned device comprises other method that produces flexible portion, for example by the tubular body with corrugated wall being provided or adopting the material more flexible than the remainder of tubular body to make the far-end of conduit.
In some applications, the inflated type band can need, and also can not need.For example, when being used for the child, endotracheal tube forms the sealing of pipe inner wall and does not use the inflated type band with the inwall of trachea, thereby and removes the easier realization of thickness that the inflated type band can reduce device and insert and control.Equally, the device that does not have the inflated type band in the specific embodiment of the present invention can not be to use in the application as the gas inner catheter, for example, and as the sleeve pipe that inserts health or animal body.
Figure 31 a, 31b and 32 shows another specific embodiment, wherein adopts one deck or duplicature, rather than adopts the inflated type band as mentioned above.In this specific embodiment, one or more have the flexible portion 202 that conduit can be provided as the otch 204 in the wall 206 of the kerf bottom 208 of hinge.Adventitia 210 is covered with otch 204.Inner membrance 212 can be placed in the conduit, and wherein the cable 214 of thread drawing mechanism is between adventitia 210 and inner membrance 212.The wall of the body passageways that adventitia 210 armour tubings insert does not contact with cable.Adventitia 210 can seal the outer surface of the conduit that forms fluid-tight seal.Can select or be further, the inner surface that inner membrance 212 can sealing duct is to form fluid-tight seal.
Figure 32 shows the cable 214 of the temporary transient bending that forms in the flexible portion of the conduit that is covered by film.Cable 214 passes the near-end of the part of the conduit that is covered by film from the near-end 216 of conduit, extends between flexible portion 202 and adventitia 210.The far-end of cable 214 is connected on the wall 206 away from otch 204.For example, cable 214 can be in the position (shown in Figure 31 a) away from adventitia 210, or is connected on the wall 206 in (as shown in figure 34) on the lower position of adventitia 210.Pull strength acts on the near-end of cable 214 at the near-end 216 of conduit.
As above-mentioned relate to the explanation of some specific embodiment, the flexible portion 202 of conduit does not need to have otch, but can otherwise form.For example, conduit can form with different polymeric materials, and the part that forms the conduit of flexible portion 202 simultaneously uses the polymeric material of different chemical characteristic to form, and its peripheral part than conduit has bigger flexibility.Equally, flexible portion 202 can make its peripheral part than conduit have bigger flexibility by heating, ultrasound wave or UV radiation treatment.
Do not use spring though this specific embodiment shows, can in conduit, use spring to realize and the identical purpose of preceding more described specific embodiments being used to.
As shown in figure 34, in the specific embodiment of Figure 31 a, used inflated type band 228.Therefore, the flexible portion of conduit 202 need be in inflated type band 228.Inflated type band 228 can be right after on the position of flexible portion 202 (as shown in figure 34), also can be positioned on the position away from flexible portion 202, perhaps also can be on the position of flexible portion 202 (as shown in Figure 8).
Figure 33 shows the flexible portion that is formed by a plurality of otch 220-226.Figure 33 shows the otch 226 that becomes 180 degree directions with otch 220,222 with 224 axis with respect to conduit.This makes conduit different directions bending planar.In addition, otch can be towards the directions around any 360 degree of the axis of conduit, thereby make conduit in out-of-plane different directions bending.Direction and Figure 19,19a, 20 can be used to control the direction of a plurality of otch with many similar shown in 20a cables.Each otch has the wall that passes the otch near-end and is connected to then just in time away from the cable on the wall of otch.The same with the explanation of aforesaid other specific embodiment, the flexible portion of conduit does not need to comprise otch, and can adopt alternate manner to form.
In the aforesaid specific embodiment of the invention and as shown in the figure, be used for the curved major tubular body, some mechanisms that comprise the gas/liquid carrier pipe of cable and minor diameter are shown as that the near-end from main body extends to flexible portion always in the wall of main tubular body.Other mechanism that is used for curved body is shown as the outside that together reaches main tubular body.Yet this means that also the mechanism that is used for the curved major tubular body in all concrete formula embodiments can extend in the wall at catheter main body, and/or can together reach the outside and/or inner of main tubular body.
By above-mentioned explanation; operation of the present invention and structure are expressly understood; but the present invention of above-mentioned demonstration and explanation is as specific implementations of the present invention; on the basis that does not break away from the subject spirit that limited by aftermentioned claim and protection domain, can make various changes and modifications to the present invention.

Claims (60)

1. equipment that is used for rapid tracheal intubation, it comprises:
Be formed with the hollow tubing conductor of the far-end being arranged to be inserted in the trachea and relative near-end;
Than the flexible portion of the more softish conduit of peripheral part of conduit, described flexible portion is near the far-end of conduit;
Be connected on the conduit and cover the film of flexible portion;
Go out from the proximal extension of flexible portion, and extending between flexible portion and the film with near the haulage gear the far-end that is connected to flexible portion; And
Thus, that flexible portion is produced is crooked for the pull strength that imposes on the near-end of traction apparatus.
2. equipment according to claim 1 also further comprises:
The additional flexibility part of the described conduit that is spaced apart from each other and is covered by supplement film, wherein additional haulage gear extends between additional flexibility part and supplement film.
3. equipment according to claim 1 also further comprises:
Wall with conduit of inside and outside surface and the passage in wall, wherein by passage, the near-end of haulage gear from the proximal extension of conduit to flexible portion;
Be formed at the exit point of the near-end of close film in the conduit, by described exit point, haulage gear stretches out to extend between flexible portion and film from wall; And
Be positioned near the junction point of far-end of flexible portion, haulage gear is connected to thereon.
4. equipment according to claim 3 is characterized in that:
Symphysis is received on the described outer surface, and also further comprises the inner membrance that is connected to inner surface, thereby forms liquid seal between inner membrance and inner surface.
5. equipment according to claim 1 is characterized in that described flexible portion makes its material from wherein removing.
6. equipment according to claim 5 is characterized in that:
Described material is therefrom removed to form hinge fraction in the part with respect to the conduit that is covered by film of conduit.
7. equipment according to claim 6 is characterized in that:
The removal of described material forms from the outer surface of conduit and penetrates into otch the inner chamber of conduit.
8. equipment according to claim 1 is characterized in that described flexible portion has the helical spring that is enclosed in wherein.
9. equipment according to claim 1 is characterized in that:
Described flexible portion is made up of the helical spring that is positioned at the conduit flexible portion, and the circumferential section that surrounds the wall of helical spring conduit is removed.
10. equipment according to claim 1 is characterized in that:
Described flexible portion comprises the structure with corrugated conduit surface, so that this part has bigger flexibility than the remainder of conduit.
11. equipment according to claim 1 is characterized in that:
Described conduit is formed by polymeric material, and the part of the conduit that is covered by film is the polymer that has the different chemical characteristic of better flexibility than peripheral part of conduit.
12. equipment according to claim 1 is characterized in that:
Described conduit is formed by polymeric material, and described flexible portion comprises the polymer of crossing with heat, ultrasound wave or UV treatment with uv radiation, and its peripheral part than conduit has bigger flexibility.
13. equipment according to claim 1 is characterized in that described haulage gear comprises at least one cable.
14. equipment according to claim 2 is characterized in that described haulage gear comprises many cables that are used at additional flexibility part bending conduit.
15. equipment according to claim 1 also further comprises many cables that are used for along at least one axis crooked flexible portion on both direction at least.
16. equipment according to claim 1 is characterized in that described haulage gear comprises a hard relatively longitudinal extension spare.
17. equipment according to claim 16 is characterized in that described longitudinal extension spare is arranged in the longitudinal extension groove on the outer wall that is formed at conduit.
18. equipment according to claim 13 is characterized in that:
Described haulage gear comprises the finger actuation trigger of the near-end that is installed to conduit, and described group of finger actuation trigger moves accessibly tension force is applied on the described at least one cable, thereby causes that conduit produces crooked in the demand zone.
19. equipment according to claim 18 also further comprises being used for the temporary transient tension force that keeps up to the latch of on purpose being removed by the operator at least one cable.
20. equipment according to claim 13 is characterized in that described at least one cable extends through the space of the prolongation in the wall of conduit.
21. equipment according to claim 13 is characterized in that described at least one cable extends through the inner chamber of conduit.
22. equipment according to claim 13 is characterized in that:
Described at least one cable formed by the material of selecting the group that constitutes from rustless steel steel wire, plastics silk thread and braided silk.
23. an equipment that is used to insert health, it comprises:
Be formed with the hollow tubing conductor of the far-end being arranged to be inserted in the health and relative near-end;
Than the flexible portion of the more softish conduit of peripheral part of conduit, described flexible portion is near the far-end of conduit;
Be connected on the conduit and cover the film of flexible portion;
Go out from the proximal extension of flexible portion, and extending between flexible portion and the film with near the haulage gear the far-end that is connected to flexible portion; And
Thus, the pull strength that imposes on the near-end of traction apparatus bends flexible portion.
24. an equipment that is used to insert health, it comprises:
By the flexible structure that the wall with outside wall surface forms, described flexible structure has is arranged to insert the far-end of health and relative near-end;
Be formed at the otch in the wall;
Be connected on the outside wall surface of described structure and cover the film of otch;
Be used for being in described structure at otch and produce temporary transient crooked haulage gear, haulage gear goes out from the proximal extension of main body, and passes from the near-end of otch, enters by otch and the formed zone of film; And
Be positioned near the junction point of far-end of otch, the far-end of haulage gear is connected thereto, and like this, it is crooked that the pull strength that imposes on the near-end of haulage gear causes that flexible structure produces in incision.
25. equipment according to claim 24 also further comprises:
By the additional cut that supplement film covers, its respectively have be used for along at least one axis from both direction at least on the haulage gear of crooked described structure.
26. an equipment that is used for rapid tracheal intubation, it comprises:
By the flexible structure that the wall with outside wall surface forms, flexible portion has is arranged to be inserted into the far-end of trachea and relative near-end;
Be formed at the otch in the wall;
Be connected on the outside wall surface of described structure and cover the film of otch;
Be used for being in described structure at otch and produce temporary transient crooked haulage gear, described haulage gear goes out from the proximal extension of described structure, and passes from the near-end of otch, enters by otch and film formed zone; And
Be positioned near the junction point of otch far-end, the far-end of haulage gear is connected thereto, and like this, it is crooked that the pull strength that imposes on the near-end of haulage gear causes that flexible structure produces in incision.
27. an equipment that is used for rapid tracheal intubation, it comprises:
Be formed with the hollow tubing conductor of the far-end being arranged to be inserted in the trachea and relative near-end;
Flexible portion than the more softish a plurality of conduits of peripheral part of conduit; And
A plurality of being used for produces temporary transient crooked driving mechanisms at flexible portion, and to flexible portion, described driving mechanism drives with temporary transient crooked hollow tubing conductor at near-end described driving mechanism from the proximal extension of conduit.
28. equipment according to claim 27 is characterized in that described driving mechanism comprises at least one cable.
29. equipment according to claim 27 is characterized in that described flexible portion makes material from wherein removing.
30. equipment according to claim 29 is characterized in that described material is removed to be formed on the hinge fraction in the conduit.
31. equipment according to claim 27 is characterized in that described flexible portion has the helical spring that is enclosed in wherein.
32. equipment according to claim 27 is characterized in that:
Described flexible portion is made up of the helical spring of the flexible portion that is positioned at conduit, and the circumferential section that surrounds the wall of helical spring conduit is removed.
33. equipment according to claim 27 is characterized in that described flexible portion is by driving mechanism and the isolated film of trachea are covered.
34. equipment according to claim 27 is characterized in that:
Described conduit is formed by polymeric material, and described flexible portion comprises polymer of crossing with heat, ultrasound wave or UV treatment with uv radiation or the polymer that has the different chemical characteristic of bigger flexibility than peripheral part of conduit.
35. an equipment that is used for rapid tracheal intubation, it comprises:
Hollow tubing conductor with the far-end being arranged to be inserted in the trachea and relative near-end;
Be connected to the inflated type band on the outer surface of the far-end of conduit and the hollow tubing conductor between the near-end; And
Be used for producing temporary transient crooked expanding chamber in the demand zone near the far-end of conduit, expanding chamber can be used for holding the fluid of pressurized;
Thus, the fluid of pressurized introducing expanding chamber causes that conduit produces crooked in the demand zone.
36. equipment according to claim 35 is characterized in that described demand zone is the part by the conduit of band covering.
37. equipment according to claim 36 is characterized in that:
Described band covers from the part of the conduit of wherein removing material, thereby makes this part have bigger flexibility than the remainder of conduit.
38., it is characterized in that the part of the wall of the conduit that covered by band is removed to form hinge fraction according to the described equipment of claim 37.
39. equipment according to claim 35 is characterized in that described zone comprises the structure that makes described part have better flexibility than the remainder of conduit.
40. equipment according to claim 36 is characterized in that described structure is the corrugated portion along catheter surface.
41., it is characterized in that according to the described equipment of claim 39:
Described conduit is formed by polymeric material, and the part of the conduit that is covered by band is the polymer that has the different chemical characteristic of better flexibility than the remainder of conduit.
42., it is characterized in that according to the described equipment of claim 39:
Described conduit is formed by polymeric material, and the part of the conduit that is covered by band comprises the polymer of crossing with hot, ultrasound wave or UV treatment with uv radiation, and its remainder than conduit has bigger flexibility.
43. an equipment that is used for rapid tracheal intubation, it comprises:
Hollow tubing conductor with the far-end being arranged to be inserted in the trachea and relative near-end;
Be connected to inflated type band at the outer surface of the far-end of conduit and the hollow tubing conductor between the near-end; And
Be used for producing temporary transient crooked haulage gear in the part of the conduit that covers by band near the far-end of conduit, the near-end of the described part of described haulage gear from the proximal extension of conduit to the conduit that covers by band, and pass outer surface near the conduit of the far-end of conduit
Thus, to cause that the part of the conduit that is covered by band produces crooked for the pull strength that imposes on the haulage gear near-end.
44., it is characterized in that according to the described equipment of claim 43:
Described band covers from the part of the conduit of wherein removing material, thereby makes this part have bigger flexibility than the remainder of conduit.
45., it is characterized in that according to the described equipment of claim 43:
The part of the wall of the conduit that is covered by band is removed, thereby forms hinge fraction.
46., it is characterized in that the part of the described conduit that covered by band has encirclement helical spring wherein according to the described equipment of claim 43.
47., it is characterized in that according to the described equipment of claim 43:
Described helical spring is positioned at the part of the conduit that is covered by band, and the circumferential section that surrounds the wall of helical spring conduit is removed.
48., it is characterized in that according to the described equipment of claim 43:
The part of the described conduit that is covered by band comprises the structure that makes described part have better flexibility than conduit remainder.
49., it is characterized in that described structure is the corrugated catheter surface according to the described equipment of claim 48.
50., it is characterized in that according to the described equipment of claim 43:
Described conduit is formed by polymeric material, and the part of the conduit that is covered by band is the polymer that has the different chemical characteristic of better flexibility than the remainder of conduit.
51., it is characterized in that according to the described equipment of claim 43:
Described conduit is formed by polymeric material, and the part of the conduit that is covered by band comprises the polymer of crossing with hot, ultrasound wave or UV treatment with uv radiation, and its remainder than conduit has bigger flexibility.
52., it is characterized in that described haulage gear comprises at least one cable according to the described equipment of claim 43.
53. according to the described equipment of claim 52, it comprises many cables that are used for along at least one axis crooked demand zone on both direction at least.
54., it is characterized in that described haulage gear comprises hard relatively longitudinal extension spare according to the described equipment of claim 43.
55., it is characterized in that described longitudinal extension spare is arranged in the longitudinal extension groove in the outer wall that is formed at conduit according to the described equipment of claim 54.
56., it is characterized in that according to the described equipment of claim 43:
Described haulage gear comprises the finger actuation trigger of the near-end that is installed to conduit, and described finger actuation trigger moves accessibly so that tension force is applied on the described at least one cable, thereby causes that conduit produces crooked in the demand zone.
57., also further comprise being used for the temporary transient tension force that at least one cable, keeps up to the latch of on purpose removing by the operator according to the described equipment of claim 52.
58., it is characterized in that described at least one cable extends through the space of the prolongation in the wall of conduit according to the described equipment of claim 52.
59., it is characterized in that described at least one cable extends through the inner chamber of conduit according to the described equipment of claim 52.
60., it is characterized in that according to the described equipment of claim 52:
Described at least one cable formed by the material of selecting the group that constitutes from rustless steel steel wire, plastics silk thread and braided silk.
CNB018238270A 2001-11-26 2001-11-26 Endotracheal tube with tip directional control and position preserving mechanism Expired - Fee Related CN100352520C (en)

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CN100352520C CN100352520C (en) 2007-12-05

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CN108882829A (en) * 2016-01-15 2018-11-23 发步医疗有限责任公司 The two-way adjustable trachea cannula that can be imaged
CN110300561A (en) * 2016-12-20 2019-10-01 W.L.戈尔及同仁股份有限公司 Anti- intubation net
CN107468316A (en) * 2017-09-12 2017-12-15 温州医科大学附属第二医院温州医科大学附属育英儿童医院 A kind of adjustable abdominal cavity puncture outfit
CN109331301A (en) * 2017-12-29 2019-02-15 上海浦灵生物科技有限公司 A kind of unilobar lung spraying device of bronchoscope cooperation
CN108785817A (en) * 2018-07-02 2018-11-13 中国福利会国际和平妇幼保健院 Visual intelligent finely tunes tracheal catheter
CN108785817B (en) * 2018-07-02 2021-09-24 中国福利会国际和平妇幼保健院 Visual intelligent fine-adjustment tracheal catheter
CN111632242A (en) * 2019-03-01 2020-09-08 孙扬 Direction-controllable tracheal catheter guiding device
CN110812649B (en) * 2019-12-11 2020-10-13 姜虹 End-tidal CO2Guiding trachea cannula device
CN110812649A (en) * 2019-12-11 2020-02-21 姜虹 End-tidal CO2Guiding trachea cannula device
CN111658938A (en) * 2020-04-30 2020-09-15 南通市第一人民医院 Double-cavity bronchial catheter for manually adjusting bending direction of auxiliary vent pipe
CN112472946A (en) * 2020-12-30 2021-03-12 泰瑞医用品(泰州)有限公司 Trachea cannula with round head structure
CN115430005A (en) * 2022-09-26 2022-12-06 广东博迈元通医疗科技有限公司 Catheter with tip flexible and adjustable in bending
CN115430005B (en) * 2022-09-26 2024-04-30 广东博迈元通医疗科技有限公司 Tip flexible bending-adjustable catheter

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IL161971A0 (en) 2005-11-20
JP2005510310A (en) 2005-04-21
AU2002239351B2 (en) 2008-07-31
EP1448258A4 (en) 2009-09-23
BR0117186A (en) 2004-11-09
BR0117186B1 (en) 2010-07-13
IS7278A (en) 2003-05-27
AU2002239351A1 (en) 2003-06-10
MXPA04004961A (en) 2004-08-11
EP1448258A1 (en) 2004-08-25
CN100352520C (en) 2007-12-05
KR20040062641A (en) 2004-07-07
NO20042169L (en) 2004-07-22

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