CN1555784A - Calcium alginate/polyhistidine medicine controlled release micro capsule and its manufacturing method - Google Patents
Calcium alginate/polyhistidine medicine controlled release micro capsule and its manufacturing method Download PDFInfo
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- CN1555784A CN1555784A CNA2003101128409A CN200310112840A CN1555784A CN 1555784 A CN1555784 A CN 1555784A CN A2003101128409 A CNA2003101128409 A CN A2003101128409A CN 200310112840 A CN200310112840 A CN 200310112840A CN 1555784 A CN1555784 A CN 1555784A
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- calcium alginate
- polyhistidyl
- microcapsule
- gel beads
- calcium
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Abstract
A release-controlled calcium alginate/polyhistidine microsoftgel is prepared from calcium alginate and polyhistidine used as both active component and filming material through electrostatic binding by use of high-voltage electrostatic dripping equipment.
Description
Technical field
The invention relates to the calcium alginate and be the glue pearl and be a kind of microcapsule and method for making that can be used for medicine and bioengineering field of cyst wall with the polyhistidyl, especially belong to the microcapsule and the method for making that are applied to the medicine sustained release.
Background technology
Microcapsule is a kind of slow release formulation, can be used as the artery embolization for treatment malignant tumor, on pharmaceutics in order to the extended treatment time, improve the drug level of target organ, and lower whole body blood drug level, improve curative effect, effectiveness such as reduced toxicity can be applicable in the controlled drug delivery system.
Polyhistidyl has excellent biological compatibility, can biodegradation, and product is nontoxic, and has trophic function and pharmacological effects such as sick and manufacturing erythrocyte such as treatment allergy, rheumatic arthritis, anemia, leukocyte.Yet there are no at present the report that polyhistidyl is prepared microcapsule as membrane material both at home and abroad.
Summary of the invention
The object of the present invention is to provide a kind of calcium alginate/polyhistidyl medicine controlled releasing microcapsule and method for making, to be applied to medicine and bioengineering field with interventional therapy effect.
Calcium alginate of the present invention/polyhistidyl medicine controlled releasing microcapsule is that the surface of calcium alginate gel beads forms the form compact and stable alginate/polyhistidyl microcapsule membrane of one deck.
Its method for making is:
The preparation of the first step, calcium alginate gel beads: by the static drop generating device, certain density sodium alginate is splashed in the certain density calcium chloride solution, gelation reaction takes place, formation has certain particle diameter and calcium alginate gel beads of uniform size;
Second step, film formation reaction: get certain density polyhistidyl solution, add calcium alginate gel beads and be carried out to film reaction, make the surface of calcium alginate gel beads form the form compact and stable alginate/polyhistidyl microcapsule membrane of one deck.
Calcium alginate of the present invention/polyhistidyl medicine controlled releasing microcapsule, the size scope is controlled in 200-1000 μ m, and size evenly, any surface finish, good sphericity.
Like this, the present invention utilizes the static combined techniques to prepare microcapsule by the high-pressure electrostatic drop generating device.Polyhistidyl is introduced in the microcapsule preparation as membrane material, because the Nutrition and the pharmacological effect of polyhistidyl and catabolite thereof, when making polyhistidyl be used for the preparation of calcium alginate/polyhistidyl medicine controlled releasing microcapsule, the microcapsule of preparing has the interventional therapy effect.This pharmaceutical carrier can keep excellent biological compatibility, macromolecular drug affinity, and inherent nutrition of its catabolite simultaneously and pharmacological function make it possess the interventional therapy function.The present invention can be used for delivery and is released in medicine and bioengineering field effective substances.
The specific embodiment
Calcium alginate of the present invention/polyhistidyl medicine controlled releasing microcapsule is that the surface of calcium alginate gel beads forms the form compact and stable alginate/polyhistidyl microcapsule membrane of one deck.
Be the concrete implementation step of the present invention below:
The first, with the sodium alginate soln of 1.8% (w/v) after 0.8 μ m, 0.45 μ m, 0.22 μ m filter, getting 4mL moves in the syringe, splash in the calcium chloride solution of 200mL1.5% (w/v) through the static drop generating device, gelation reaction takes place, and forms the calcium alginate gel beads with certain size.
The second, calcium alginate gel beads is added in 10mL0.08% (w/v) the polyhistidyl solution and carried out film forming 10 minutes, make the surface of calcium alginate gel beads form the form compact and stable alginate/polyhistidyl microcapsule membrane of one deck.
Three, by above-mentioned method, it is even to make size, and size scope 200-1000 μ m is controlled, the calcium alginate of any surface finish and good sphericity/polyhistidyl medicine controlled releasing microcapsule.
Claims (3)
1, calcium alginate/polyhistidyl medicine controlled releasing microcapsule is characterized in that: the surface at calcium alginate gel beads forms one deck alginate/polyhistidyl microcapsule membrane, and this pharmaceutical carrier has the interventional therapy function.
2, the method for making of calcium alginate/polyhistidyl medicine controlled releasing microcapsule is characterized in that:
The preparation of the first step, calcium alginate gel beads: by the static drop generating device, certain density sodium alginate is splashed in the certain density calcium chloride solution, gelation reaction takes place, formation has certain particle diameter and calcium alginate gel beads of uniform size;
Second step, film formation reaction: get certain density polyhistidyl solution, add calcium alginate gel beads and be carried out to film reaction, make the surface of calcium alginate gel beads form the form compact and stable alginate/polyhistidyl microcapsule membrane of one deck.
3, calcium alginate as claimed in claim 1/polyhistidyl medicine controlled releasing microcapsule, it is characterized in that: the size scope is controlled in 200-1000 μ m, and size is even, any surface finish and good sphericity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101128409A CN1555784A (en) | 2003-12-31 | 2003-12-31 | Calcium alginate/polyhistidine medicine controlled release micro capsule and its manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101128409A CN1555784A (en) | 2003-12-31 | 2003-12-31 | Calcium alginate/polyhistidine medicine controlled release micro capsule and its manufacturing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1555784A true CN1555784A (en) | 2004-12-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101128409A Pending CN1555784A (en) | 2003-12-31 | 2003-12-31 | Calcium alginate/polyhistidine medicine controlled release micro capsule and its manufacturing method |
Country Status (1)
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| CN (1) | CN1555784A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009100645A1 (en) * | 2008-01-25 | 2009-08-20 | Tuo Jin | Polycationic gene carriers formed of endogenous amino group-bearing monomers |
| CN101947212A (en) * | 2010-09-08 | 2011-01-19 | 华侨大学 | Micro-embedded medicament carrier and preparation method thereof |
| CN102516534A (en) * | 2011-11-14 | 2012-06-27 | 上海交通大学 | Polycation capable of being degraded into spermine, and synthesis method and nanoparticles thereof |
-
2003
- 2003-12-31 CN CNA2003101128409A patent/CN1555784A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009100645A1 (en) * | 2008-01-25 | 2009-08-20 | Tuo Jin | Polycationic gene carriers formed of endogenous amino group-bearing monomers |
| CN102083972B (en) * | 2008-01-25 | 2013-03-06 | 金拓 | Polycationic gene carriers formed of endogenous amino group-bearing monomers |
| CN101947212A (en) * | 2010-09-08 | 2011-01-19 | 华侨大学 | Micro-embedded medicament carrier and preparation method thereof |
| CN102516534A (en) * | 2011-11-14 | 2012-06-27 | 上海交通大学 | Polycation capable of being degraded into spermine, and synthesis method and nanoparticles thereof |
| CN102516534B (en) * | 2011-11-14 | 2013-11-20 | 上海交通大学 | Polycation capable of being degraded into spermine, and synthesis method and nanoparticles thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |