CN1554650A - Process for the preparation of vialoguestamin d analogs - Google Patents
Process for the preparation of vialoguestamin d analogs Download PDFInfo
- Publication number
- CN1554650A CN1554650A CNA2004100476902A CN200410047690A CN1554650A CN 1554650 A CN1554650 A CN 1554650A CN A2004100476902 A CNA2004100476902 A CN A2004100476902A CN 200410047690 A CN200410047690 A CN 200410047690A CN 1554650 A CN1554650 A CN 1554650A
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- silyl
- obtains
- enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract description 17
- 238000002360 preparation method Methods 0.000 title description 32
- 150000001875 compounds Chemical class 0.000 claims abstract description 151
- -1 triethylsilyl Chemical group 0.000 claims description 45
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims description 22
- 125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 claims description 13
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 13
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 38
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract description 31
- 229910052799 carbon Inorganic materials 0.000 abstract description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 16
- 239000003054 catalyst Substances 0.000 abstract description 15
- 229910052763 palladium Inorganic materials 0.000 abstract description 13
- 239000000543 intermediate Substances 0.000 abstract description 11
- 229930003316 Vitamin D Natural products 0.000 abstract description 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract description 6
- 235000019166 vitamin D Nutrition 0.000 abstract description 6
- 239000011710 vitamin D Substances 0.000 abstract description 6
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract description 6
- 229940046008 vitamin d Drugs 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000000707 stereoselective effect Effects 0.000 abstract description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 132
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 83
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 57
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 46
- 235000019439 ethyl acetate Nutrition 0.000 description 44
- 239000000203 mixture Substances 0.000 description 40
- 239000000243 solution Substances 0.000 description 38
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 28
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 28
- 238000005406 washing Methods 0.000 description 26
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 24
- 229910052757 nitrogen Inorganic materials 0.000 description 23
- 239000011541 reaction mixture Substances 0.000 description 18
- 230000006837 decompression Effects 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 238000005481 NMR spectroscopy Methods 0.000 description 15
- 230000000903 blocking effect Effects 0.000 description 15
- 150000002576 ketones Chemical class 0.000 description 15
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 14
- 238000001035 drying Methods 0.000 description 14
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 14
- 239000012043 crude product Substances 0.000 description 13
- 238000004043 dyeing Methods 0.000 description 13
- 239000007787 solid Substances 0.000 description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 11
- 239000012074 organic phase Substances 0.000 description 11
- 238000003756 stirring Methods 0.000 description 11
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 239000002994 raw material Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 9
- 150000002118 epoxides Chemical group 0.000 description 9
- 150000002460 imidazoles Chemical class 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 8
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 7
- 239000006227 byproduct Substances 0.000 description 7
- 238000001816 cooling Methods 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 7
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 7
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 239000005457 ice water Substances 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 description 6
- 235000015497 potassium bicarbonate Nutrition 0.000 description 6
- 239000011736 potassium bicarbonate Substances 0.000 description 6
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- KFSLWBXXFJQRDL-UHFFFAOYSA-N peroxyacetic acid Substances CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- 229960001866 silicon dioxide Drugs 0.000 description 5
- KYLUAQBYONVMCP-UHFFFAOYSA-N (2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P KYLUAQBYONVMCP-UHFFFAOYSA-N 0.000 description 4
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
- 238000007792 addition Methods 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 238000003810 ethyl acetate extraction Methods 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 150000002561 ketenes Chemical class 0.000 description 4
- 238000003760 magnetic stirring Methods 0.000 description 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- FSJSYDFBTIVUFD-SUKNRPLKSA-N (z)-4-hydroxypent-3-en-2-one;oxovanadium Chemical compound [V]=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O FSJSYDFBTIVUFD-SUKNRPLKSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 238000006555 catalytic reaction Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KOPOQZFJUQMUML-UHFFFAOYSA-N chlorosilane Chemical compound Cl[SiH3] KOPOQZFJUQMUML-UHFFFAOYSA-N 0.000 description 3
- 239000012230 colorless oil Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000006735 epoxidation reaction Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- UQPUONNXJVWHRM-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 UQPUONNXJVWHRM-UHFFFAOYSA-N 0.000 description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 150000003333 secondary alcohols Chemical class 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- NBRKLOOSMBRFMH-UHFFFAOYSA-N tert-butyl chloride Chemical compound CC(C)(C)Cl NBRKLOOSMBRFMH-UHFFFAOYSA-N 0.000 description 3
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- ORPNDFMZTDVBGA-UHFFFAOYSA-N (2-methoxyphenyl)phosphane Chemical compound COC1=CC=CC=C1P ORPNDFMZTDVBGA-UHFFFAOYSA-N 0.000 description 2
- QFNNMPZGMHATPO-UHFFFAOYSA-N (3-methoxyphenyl)phosphane Chemical compound COC1=CC=CC(P)=C1 QFNNMPZGMHATPO-UHFFFAOYSA-N 0.000 description 2
- SVDZDXBQOBWHLE-UHFFFAOYSA-N (4-fluorophenyl)phosphane Chemical compound FC1=CC=C(P)C=C1 SVDZDXBQOBWHLE-UHFFFAOYSA-N 0.000 description 2
- VXLQXFQDOGUAPA-UHFFFAOYSA-N (4-methoxyphenyl)phosphane Chemical compound COC1=CC=C(P)C=C1 VXLQXFQDOGUAPA-UHFFFAOYSA-N 0.000 description 2
- HUCQPHINKBNKRU-UHFFFAOYSA-N (4-methylphenyl)phosphane Chemical compound CC1=CC=C(P)C=C1 HUCQPHINKBNKRU-UHFFFAOYSA-N 0.000 description 2
- IZPIZCAYJQCTNG-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoro-2-phenylpropan-2-ol Chemical compound FC(F)(F)C(C(F)(F)F)(O)C1=CC=CC=C1 IZPIZCAYJQCTNG-UHFFFAOYSA-N 0.000 description 2
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- 238000006220 Baeyer-Villiger oxidation reaction Methods 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 101150003085 Pdcl gene Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- IQUVKELVRNJFAE-UHFFFAOYSA-N [4-(trifluoromethyl)phenyl]phosphane Chemical compound FC(F)(F)C1=CC=C(P)C=C1 IQUVKELVRNJFAE-UHFFFAOYSA-N 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 235000020964 calcitriol Nutrition 0.000 description 2
- 239000011612 calcitriol Substances 0.000 description 2
- 235000011089 carbon dioxide Nutrition 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- WMKGGPCROCCUDY-PHEQNACWSA-N dibenzylideneacetone Chemical group C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 WMKGGPCROCCUDY-PHEQNACWSA-N 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- MSBPSFSYBUUPMC-UHFFFAOYSA-N furan-2-ylphosphane Chemical compound PC1=CC=CO1 MSBPSFSYBUUPMC-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 2
- 238000006317 isomerization reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- ZOUWOGOTHLRRLS-UHFFFAOYSA-N palladium;phosphane Chemical group P.[Pd] ZOUWOGOTHLRRLS-UHFFFAOYSA-N 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 235000012736 patent blue V Nutrition 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 150000003509 tertiary alcohols Chemical class 0.000 description 2
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- 239000001211 (E)-4-phenylbut-3-en-2-one Substances 0.000 description 1
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- JDIIGWSSTNUWGK-UHFFFAOYSA-N 1h-imidazol-3-ium;chloride Chemical compound [Cl-].[NH2+]1C=CN=C1 JDIIGWSSTNUWGK-UHFFFAOYSA-N 0.000 description 1
- DAJDFNATUYTLKK-UHFFFAOYSA-N 2-hydroperoxy-2-methylpropane;nonane Chemical compound CC(C)(C)OO.CCCCCCCCC DAJDFNATUYTLKK-UHFFFAOYSA-N 0.000 description 1
- AAEZMHSWRQVQEK-UHFFFAOYSA-N 2-methylideneoxirane Chemical compound C=C1CO1 AAEZMHSWRQVQEK-UHFFFAOYSA-N 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 1
- 229960000549 4-dimethylaminophenol Drugs 0.000 description 1
- SKDHHIUENRGTHK-UHFFFAOYSA-N 4-nitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=C(C(Cl)=O)C=C1 SKDHHIUENRGTHK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- GKRYOTUQPZKDFB-UHFFFAOYSA-N C1=CC=CC=C1C(=O)OO.[Cl] Chemical compound C1=CC=CC=C1C(=O)OO.[Cl] GKRYOTUQPZKDFB-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 238000005698 Diels-Alder reaction Methods 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 238000006546 Horner-Wadsworth-Emmons reaction Methods 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 101000905241 Mus musculus Heart- and neural crest derivatives-expressed protein 1 Proteins 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 238000007171 acid catalysis Methods 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- 229930008407 benzylideneacetone Natural products 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 150000007516 brønsted-lowry acids Chemical class 0.000 description 1
- 150000007528 brønsted-lowry bases Chemical class 0.000 description 1
- HXLVDKGPVGFXTH-UHFFFAOYSA-N butyl(dimethyl)silane Chemical group CCCC[SiH](C)C HXLVDKGPVGFXTH-UHFFFAOYSA-N 0.000 description 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
- 229960005084 calcitriol Drugs 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- WUOIAOOSKMHJOV-UHFFFAOYSA-N ethyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(CC)C1=CC=CC=C1 WUOIAOOSKMHJOV-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 239000002035 hexane extract Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-M hydroperoxide group Chemical group [O-]O MHAJPDPJQMAIIY-UHFFFAOYSA-M 0.000 description 1
- SIAPCJWMELPYOE-UHFFFAOYSA-N lithium hydride Chemical compound [LiH] SIAPCJWMELPYOE-UHFFFAOYSA-N 0.000 description 1
- 229910000103 lithium hydride Inorganic materials 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
- LULAYUGMBFYYEX-UHFFFAOYSA-N metachloroperbenzoic acid Natural products OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- WURFKUQACINBSI-UHFFFAOYSA-M ozonide Chemical compound [O]O[O-] WURFKUQACINBSI-UHFFFAOYSA-M 0.000 description 1
- 238000005949 ozonolysis reaction Methods 0.000 description 1
- MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical class [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 description 1
- JKDRQYIYVJVOPF-FDGPNNRMSA-L palladium(ii) acetylacetonate Chemical compound [Pd+2].C\C([O-])=C\C(C)=O.C\C([O-])=C\C(C)=O JKDRQYIYVJVOPF-FDGPNNRMSA-L 0.000 description 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229940106904 rocaltrol Drugs 0.000 description 1
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000003797 solvolysis reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A stereospecific method for accomplishing the below reaction:results in the compound of formula 2 having the same stereochemistry at both carbon 1 and carbon 3 as that in the compound of formula 1. Thus, if carbon 3 is in the R-configuration in the compound of formula 1, then carbon 3 will be in the R-configuration in the compound of resulting formula 2. In the above process, R1 is C1-C6 alkyl that can be straight-chain or branched. The process functions using a fluorinated alcohol having a pKa less than about 9, in the presence of a palladium catalyst. The compounds of formula 1, as well as novel intermediates in this process, are useful in manufacturing vitamin D analogs.
Description
The present invention relates to be used to prepare the method for novel vitamin D analogues, as calcitriol, commodity are called Rocaltrol
Be used to prepare the common a plurality of steps of needs of method and the chromatogram purification of novel vitamin D analogues.Referring to, Norman, A.W.; Okamura, W.H.PCT International Application No. WO 9916452 A1 990408; Chemical abstracts (Chem Abstr.) 130:282223, Batcho, A.D.; Bryce, G.F.; Hennessy, B.M.; Iacobelli, J.A.; Uskokovic, M.R. European patent application EP 808833,1997; Chemical abstracts (Chem Abstr.) 128:48406, Nestor, J.J.; Manchand, P.S.; Uskokovic, M.R., Vickery, B.H.US 5872113,1997; Chemical abstracts (Chem Abstr.) 130:168545.The present invention is devoted to provide a kind of method of effectively synthesizing the A loop section of this novel vitamin D analogues.
The invention provides the method that a kind of steroselectivity ground prepares following formula: compound:
Or their enantiomer
R wherein
1Be C
1-C
6Alkyl, R
2Be hydroxy-protective group,
Comprising
For formula 2AA and 2AA
*The preparation of compound comprises the compound with following formula
Or their enantiomer
R wherein
1And R
2The same, carbon 1 is distinguished identical and formula 1AA with 3 stereochemistry in the compound of the compound of formula 1AA and formula 2AA
*Compound and formula 2AA
*Compound in carbon 1 identical respectively with 3 stereochemistry, respectively in the presence of palladium catalyst, with pK
aBe lower than about 9 fluorinated alohol reaction, respectively production 2AA or 2AA
*Compound;
For formula 2BB and 2BB
*The preparation of compound comprises the compound with following formula
Or their enantiomer
R wherein
1And R
2The same, carbon 1 is distinguished identical and formula 1BB with 3 stereochemistry in the compound of the compound of formula 1BB and formula 2BB
*Compound and formula 2BB
*Compound in carbon 1 identical respectively with 3 stereochemistry, respectively in the presence of palladium catalyst, with pK
aBe lower than about 9 fluorinated alohol reaction, respectively production 2BB or 2BB
*Compound.
Reaction is preferably carried out in the presence of palladium catalyst, wherein palladium catalyst is palladium-phosphine catalyst, as palladium-triaryl phosphine, particularly is selected from down the palladium-triphenylphosphine of group: palladium-three (2-methoxyphenyl) phosphine, palladium-three (3-methoxyphenyl) phosphine, palladium-three (4-methoxyphenyl) phosphine, palladium-three (o-tolyl) phosphine, palladium-three (tolyl) phosphine, palladium-three (p-methylphenyl) phosphine, palladium-three (4-fluorophenyl) phosphine, palladium-three (p-trifluoromethyl phenyl) phosphine, and palladium-three (2-furyl) phosphine.Another preferred palladium catalyst is a palladium-1,2-two (diphenylphosphino) ethane.
Fluorinated alohol preferably from organizing down, comprising:
Wherein X is phenyl or CF
3
For example
Or
Or
The present invention also provides and has been used for preparation formula 2AA, 2AA
*, 2BB, and 2BB
*The new intermediate of compound, therefore, the present invention
Relate to compound with following formula structure:
R wherein
1Be C
1-C
6Alkyl;
Preferably relate to compound with following formula structure:
R wherein
1Be C
1-C
6Alkyl;
Relate to new intermediate with following formula structure:
R wherein
1Be C
1-C
6Alkyl;
Preferably relate to compound with following formula structure:
R wherein
1Be C
1-C
6Alkyl;
Relate to intermediate with following formula structure:
R wherein
1Be C
1-C
6Alkyl;
Preferably relate to compound with following formula structure:
R wherein
1Be C
1-C
6Alkyl;
Relate to and comprise new intermediate with following formula structural compounds:
R wherein
1Be C
1-C
6Alkyl;
Preferably relate to compound with following formula structure:
R wherein
1Be C
1-C
6Alkyl;
Relate to new intermediate with following formula structure
R wherein
1Be C
1-C
6Alkyl; With
R
2For being selected from down the hydroxy-protective group of group; comprise trimethyl silyl; triethylsilyl; the tripropyl silyl; the triisopropyl silyl, t-butyldimethylsilyl (" TBS "), dimethyl hexyl silyl; triphenyl silyl, and t-butyldiphenylsilyl.
Relate to compound with following formula structure:
R wherein
1Be C
1-C
6Alkyl,
Or the structure of following formula
R wherein
2For being selected from down the hydroxy-protective group of group, comprise trimethyl silyl, triethylsilyl, the tripropyl silyl, triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl; Preferably relate to compound with following formula structure:
Relate to new intermediate with following formula
R wherein
3Be C
1-C
6Alkyl, phenyl, 4-nitrophenyl, or CF
3
The intermediate that preferably relates to following formula
Or
The invention further relates to compound with following structure:
With relate to compound with following structure:
R wherein
2For being selected from down the hydroxy-protective group of group, comprise trimethyl silyl, triethylsilyl, the tripropyl silyl, triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl;
Preferably relate to compound with following structure:
The new intermediate that the present invention further provides is the compound with following structure:
R wherein
1Be C
1-C
6Alkyl, and R
2For being selected from down the hydroxy-protective group of group, comprise trimethyl silyl, triethylsilyl, the tripropyl silyl, triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl;
Or compound with following structure:
R wherein
1Be C
1-C
6Alkyl;
Or compound with following structure:
R wherein
2For being selected from down the hydroxy-protective group of group, comprise trimethyl silyl, triethylsilyl, the tripropyl silyl, triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl; Or compound with following structure:
New compound also comprises the compound with following structure:
R wherein
1Be C
1-C
6Alkyl, and R
2For being selected from down the hydroxy-protective group of group, comprise trimethyl silyl, triethylsilyl, the tripropyl silyl, triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl;
The example of these compounds is the compound with following structure:
R wherein
1Be C
1-C
6Alkyl;
Or compound with following structure:
R wherein
2For being selected from down the hydroxy-protective group of group, comprise trimethyl silyl, triethylsilyl, the tripropyl silyl, triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl; The compound that preferably has following structure:
The above-mentioned new intermediate and the enantiomer of compound also are parts of the present invention.
Be described in terms of preferred embodiments the present invention now.The purpose that proposes these embodiments is in order to understand the present invention, rather than as restriction.
Generality of the present invention relates to Stereoselective and the regioselective method that formula 1 compound is transformed an accepted way of doing sth 2 compounds.As explained below, some difference of existence between the compound (promptly in six-ring planar both sides) of the formula 1 of the trans connection of replacement of the compound (promptly in six-ring planar the same side) of the formula 1 that the replacement cis of carbon 1 and 3 connects and carbon 1 and 3.
Formula 2 compounds of this method preparation have identical relative and absolute stereo chemistry with the carbon 1 and the carbon 3 of formula 1 compound.Therefore, if the carbon 1 in formula 1 compound is the R-configuration, the carbon 1 in formula 2 compounds that obtain so also is the R-configuration.In aforesaid method, R
1Can be straight or branched C
1-C
6Alkyl, for example, methyl, ethyl, propyl group, sec.-propyl, butyl (primary, the second month in a season or uncle), amyl group (primary, the second month in a season or uncle), or hexyl (primary, the second month in a season or uncle).R
2Be hydroxy-protective group.Those skilled in the art can select blocking group at an easy rate.But preferred silyl blocking group is as t-butyldimethylsilyl (" TBS ").
The key that forms the epoxide ring can be in the top or the bottom of planes of molecules.When the epoxide ring in the bottom, plane, the methyl group of connection is portion in the plane.Equally, when epoxide ring portion in the plane, the methyl group of connection is in the bottom, plane.
For example, following situation, can take place in the cis that is substituted by when carbon 1 and 3:
Trans when being substituted by of carbon 1 and 3, following situation can take place:
The compound of formula 2A-D is used to prepare novel vitamin D analogues, for example, the compound of formula 2A, referring to Shiuey, S.J.; Kulesha, I; Baggiolini E.G.; Uskokovic, M.R. organic chemistry impurity (J.Org.Chem.), 1990,55,243; The compound of formula 2B, referring to Nagasawa, K.; Zako, Y; Ishihara, H.; Shimizu, I. tetrahedron communication (Tetrahedron Lett.), 1991,32,4937, Nagasawa, K.; Zako, Y; Ishihara, H.; Shimizu, I. organic chemistry impurity (J.Org.Chem.), 1993,58,2523; The compound of formula 2C, referring to Hatakeyama, S.; Iwabuchi, Y.PCT International Application No. WO 9915499 A1 990401; Chemical abstracts (Chem Abstr.) 130:252533; With the compound of formula 2D, referring to Shimizu, N.Jpn.Kokai Tokkyo Koho JP04305553 A2 921028; Chemical abstracts (Chem Abstr.) 118:191249, Shimizu, N.Jpn.Kokai Tokkyo Koho JP 04305548 A2 921028; Chemical abstracts (Chem Abstr.) 118:212477, Minojima, T.; Tomimori, k.; .Kato, Y.Jpn.Kokai Tokkyo Koho JP02286647 A2 901126; Chemical abstracts (Chem Abstr.) 114:184872.
Compound formula 1A and 1C are enantiomer, can prepare from known compound.For example, the preparation of formula 1A, starting raw material can be (+)-Karvon, the preparation of formula 1C, starting raw material can be (-)-Karvon [Liu, H.J.; Zhu, the B.Y. chemical impurity of Canada (Can.J.Chem.) 1991,69,2008].The compound of formula 3 or its enantiomer, can pass through (+)-Karvon or (-)-Karvon obtains with the acetic ester reaction respectively, as the methylene diacetate ester, the ethyl acetic ester, propyl group acetic ester, sec.-propyl acetic ester, the tertiary butyl, isobutyl-or sec-butyl acetic ester, amyl group (primary, the second month in a season or uncle) acetic ester, or hexyl (primary, the second month in a season or uncle) acetic ester are according to top disclosed step.A skilled chemist of having seen specification sheets of the present invention can know how to prepare given enantiomer by selecting the starting raw material of corresponding enantiomer.
In the compound of such scheme, R
1Can be straight or branched C
1-C
6Alkyl, for example, methyl, ethyl, propyl group, sec.-propyl, butyl (primary, the second month in a season or uncle), amyl group (primary, the second month in a season or uncle), or hexyl (primary, the second month in a season or uncle).R
2Be hydroxy-protective group, for example the silyl blocking group.
Those skilled in the art can select blocking group at an easy rate, referring to, T.W.Greene for example, P.G.M.Wuts, the blocking group in the organic synthesis, second edition, John Wiley ﹠amp; Sons, 1991.The acceptable hydroxy-protective group that uses among the present invention comprises silyl ether; as trimethyl silyl; triethylsilyl; the tripropyl silyl; the triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl; triphenyl silyl, and t-butyldiphenylsilyl.
Steps A in the aforesaid method is highly regional and stereoselective epoxidation (vinyl carbinol of known formula 3 obtains the epoxide of formula 4 by the catalysis of vanadyl acetylacetonate) [Liu, H.J.; Zhu, the B.Y. chemical impurity of Canada (Can.J.Chem.) 1991,69,2008].Pendant double bonds is carried out ozonize then, obtains the ketone of formula 5.The ketone of formula 5 carries out the Baeyer-Villiger oxidation, with the acetic ester 6 that posthydrolysis obtains, obtains alcohol 7.Secondary alcohol carries out the selectivity silylanizing, and the tertiary alcohol dewaters, and obtains the unsaturated ester of formula 1A (E) configuration.
Steps A
The vinyl carbinol of formula 3 can be in methylene dichloride epoxidation, the vanadyl acetylacetonate of applied catalysis amount and the tert-butyl hydroperoxide nonane solution in the presence of molecular sieve.Perhaps, reaction can be used 1.5mol% vanadium mixture and about 1.2 normal hydroperoxide by reflux of cyclohexane (anhydrating by constant the removing of Dean-Stark thickener), complete reaction after 5 hours, and productive rate is very high.The epoxide of formula 4 tends to instability.Therefore, suggestion is used saturated sodium bicarbonate solution washing reaction mixture several times then with the hydroperoxide that it is excessive that sodium bisulfite quenches, and concentrates under 30 ℃ of decompressions, and is dry under the room temperature high vacuum.The ozonolysis that the crude mixture that obtains and nonane (hydrogen peroxide solution) can be carried out step B then.
Step B
The methanol solution that contains formula 4 epoxide can with the dry ice-propanone cooling, carry out ozonize in the presence of sodium bicarbonate.(Polymetrics Inc.) produces ozonized air (pressure 6PSIG can to use Polymetrics Laboratory Ozonator Model T-816; Flow velocity 4LPM; 110V).Reduce with dimethylsulphide subsequently, obtain the ketone of formula 5.Be lower than 30 ℃ concentrate before, should be by removing by filter sodium bicarbonate.
Step C
Formula 5 compounds can be in the mixture of hexane and ethyl acetate, and (there not being the excessive inclined to one side chlorine peroxybenzoic acid of alkali) carries out oxidation under the Baeyer-Villiger oxidizing condition of modifying.More substantial hexane can accelerated reaction in the mixture.But too a high proportion of hexane and ethyl acetate can form other layer in reaction mixture, produce by product.Find that hexane and 3: 1 mixture of ethyl acetate are suitable especially.
Step D
The acetic ester of formula 6 can be in methyl alcohol, and the sodium methylate of applied catalysis amount (15mol%) is hydrolyzed with the frozen water cooling.Then can be in ethyl acetate-hexane the product of crystallization formula 7, separate.
Step e
The selective protection of secondary alcohol in the formula 7 (tertiary alcohol does not carry out) can be used known resist technology and obtain, as the imidazoles in tert-butyldimethylsilyl chloride and the tetrahydrofuran (THF).Other silyl blocking group; as trimethyl silyl, triethylsilyl, tripropyl silyl; the triisopropyl silyl; dimethyl hexyl silyl, triphenyl silyl and t-butyldiphenylsilyl blocking group can use equally; the compound of corresponding silyl chloride cotype 7 reacts in the presence of alkali; as imidazoles, pyridine, or other fragrance or aliphatic tertiary amine.Can be from the sedimentary imidazole hydrochloride of reaction mixture by removing by filter.Can concentrated filtrate, carry out next step without being further purified then.Perhaps, can in pyridine, carry out silylanizing, reaction mixture directly can be added then in the dehydrating mixt of step F (that is pyridine/thionyl chloride).
Step F
By handling, (for example silyl) ether dehydration of the protection of formula 8 can be obtained the compound of formula 1A with the thionyl chloride in the pyridine.The THF solution of formula 8 compounds is joined in preformed cold thionyl chloride/pyridine mixtures, reduce the formation of by product.Product can not purifiedly be used for next step.Although this crude product may contain by product blocking group (for example silyl), blocking group should be stablized under dehydration conditions.
Compound formula 1B and 1D are enantiomer, can prepare from known compound.For example, the preparation of formula 1B, starting raw material can be (+)-Karvon [Okamura, W.H.; Aurrecoechea, J.M.; Gibbs, R.A.; Norman, A.W. organic chemistry impurity (J.Org.Chem.), 1989,54,4072], the preparation of formula 1D, starting raw material can be (-)-Karvon [Jones, Jole, Jr.; Kover, W.B. synthesising communication (Synth.Commun.), 1995,25,3907].Therefore, the compound of formula 9 or its enantiomer, the condition according to enumerating in top the disclosing obtains by cis-selectivity (diastereoselective) epoxidation respectively.A skilled chemist of having seen specification sheets of the present invention can know how to prepare given enantiomer by selecting the starting raw material of corresponding enantiomer.
Step G
The compound of known formula 9 [Klein, E.; Ohloff, G. tetrahedron (Tetrahedron), 1963,19,1091, Okamura, W.H.; Aurrecoechea, J.M.; Gibbs, R.A.; Norman, A.W. organic chemistry magazine (J.Org.Chem.), 1989,54,4072].
(70 ℃) at low temperatures, 1 of the compound generation ozone of formula 9,3-two polar ring additions obtain ozonide, its at high temperature (for example, room temperature) by contrary-1,3-two polar ring additions, release formaldehyde forms triiron tetroxide.In the presence of methyl alcohol (as cosolvent), triiron tetroxide is captured by ethanol effectively, and the hydroperoxide of the formula 10A that obtains expecting (step G1) then with its acidylate, obtain the compound (step G2) of formula 10B.The variation of common acidylate is to be easy to, significantly for those of ordinary skills.In the compound of formula 10B, R
3Be C
1-C
6Alkyl, phenyl, 4-nitrophenyl, or CF
3Those skilled in the art can carry out these changes at an easy rate.
Excessive methyl alcohol may disturb acidylate.But can obtain clean reaction with 4 normal methyl alcohol.Then, can with these hydroperoxide in position with 7 normal diacetyl oxide and triethylamines, in the presence of-5 ℃, the DMAP of catalytic amount, carry out acidylate, obtain Peracetic Acid ester 10B, wherein R is a methyl.Can also use other acylating agent, the peroxyester that obtains be carried out Griegee as described below reset.The acylating agent that should be fit to is aliphatics and aromatic acyl halogen (chlorine or bromine), and acid anhydrides, as Acetyl Chloride 98Min., and diacetyl oxide, propionyl chloride, Benzoyl chloride, 4-nitrobenzoyl chloride, and trifluoroacetic anhydride.As mentioned above, these acylating agents can (as triethylamine) react with hydroperoxide 10A in the presence of alkali, obtain corresponding Peracetic Acid ester 10B, and wherein R is methyl, ethyl, phenyl, 4-nitrophenyl, trifluoromethyl.But R is preferably methyl among the Peracetic Acid ester 10B.
Step H1
The peroxyester of formula 10B carries out Griegee immediately to be reset, and obtains the alcohol of formula 11, is preferably methyl alcohol.The Peracetic Acid ester of 10B tends to instability.Therefore, can add sodium acetate, prevent the acid catalysis solvolysis of the compound of formula 10 to corresponding dimethyl-acetal, step H1 preferably carries out behind step G at once.For formula 11 compounds that obtain purifying, should use the water workup of reaction mixture, to remove the by product of bronsted lowry acids and bases bronsted lowry.
Step H2
After carrying out exchange of solvent with acetonitrile, can protect (for example, silylanizing) to the product of formula 11, obtain the ketone of formula 12.Can under 45 ℃, high vacuum, remove volatile relatively blocking group (for example, silyl) by product, obtain the crude product of formula 12.
The protection of secondary alcohol can be used known resist technology acquisition in the formula 11, for example, uses tert-butyldimethylsilyl chloride and imidazoles.Other silyl blocking group, for example, trimethyl silyl; triethylsilyl, tripropyl silyl, triisopropyl silyl; dimethyl hexyl silyl, triphenyl silyl and t-butyldiphenylsilyl blocking group can use equally; under the condition of control; the compound of corresponding silyl chloride cotype 7 reacts in the presence of alkali, as imidazoles, and pyridine; or other fragrance or aliphatic tertiary amine, to reduce the elimination of silyl.
It should be noted that the product that Griegee resets in the methyl alcohol is the alcohol of formula 11, in reaction, never observe corresponding acetic ester.This is opposite with typical Griegee rearrangement process (one jar of acetylize in the methylene dichloride and rearrangement: Schreiber, S.L.; Liew, W.F. tetrahedron communication (TetrahedronLett.), 1983,24,2363), wherein acetic ester obtains as principal product usually, and a spot of correspondent alcohol.Because the elimination of acetoxyl group, acetic ester is problematic to the hydrolysis subsequently of alcohol.
Step I
Can use 2.2 normal three-R
1Phosphine acyl acetic acid ester (R wherein
1Be straight or branched C
1-C
6Alkyl) with 1.8 normal lithium hydrides (in relative THF in a small amount); in low relatively temperature (11 ℃) with under than the long reaction times (20 hours); carry out the Wittig-Horner reaction of formula 12 compounds, to reduce the elimination of blocking group (for example, silyloxy).About 7-9 of the formula 1B compound that can obtain to expect thus and its Z-isomer (formula 1*B compound): 1 mixture.
In order to explain the inventive point of this reaction, generate the reaction of corresponding formula 2A class (formula 2A ') with reference to formula 1A class (formula 1A '), this reaction further is discussed.For its enantiomer-compound 1C, and reaction and its enantiomer-compound 1D that compound 1B generates 2B generate 2D, has same principle.
Above reaction, when in THF, 65 ℃ of following using palladiums (O) triphenylphosphine [Suzuki, M.; Oda, Y.; Noyori, R. Journal of the American Chemical Society (J.Am.Chem.Soc.), 1979,101,1623], cause the isomerization of epoxide 1A ', 1: 3 the mixture of isomery ketenes of formula 2A ' vinyl carbinol that obtains expecting and formula 13 (HPLC is at the per-cent peak area of 220nm).[for example, triaryl phosphine is as triphenylphosphine to have found the phosphine part, three (2-methoxyphenyl) phosphine, three (3-methoxyphenyl) phosphine, three (4-methoxyphenyl) phosphine, three (o-tolyl) phosphine, three (tolyl) phosphine, three (p-methylphenyl) phosphine, three (4-fluorophenyl) phosphine, three (p-trifluoromethyl phenyl) phosphines and three (2-furyl) phosphine, and aryl phosphine, as 1,2-two (diphenylphosphino) ethane] and the isomerization of palladium (O) assembly catalyze, with adding fluorinated alohol [for example, 1,1,1,3,3,3-hexafluoro-phenyl-2-propyl alcohol and 1,3-two (1,1,1,3,3,3-hexafluoro-2-hydroxypropyl) benzene, perfluoro-t-butanols], can increase the output (comparing) of the formula 2A ' vinyl carbinol that needs with unwanted formula 13 ketone, can also improve the circulation of triphenylphosphine palladium phosphine catalyst.Palladium-phosphine catalyst can be before reaction at the scene from commercial palladium source (as Pd
2Dba
3(CHCl
3) (dba represents dibenzalacetone)) and excessive (4-5 equivalent usually) corresponding phosphine part (as triphenylphosphine) preparation.Can also use other palladium source, as palladium (O) mixture Pd
2Dba
3, Pddba
2, and palladium (II) salt Pd (OAC)
2, PdCl
2, [allyl group PdCl]
2, and Pd (acac)
2(acac represents the Acetyl Acetone acid esters).Perhaps, can prepare palladium (O)-phosphine catalyst respectively,, in reaction, use as tetrakis triphenylphosphine palladium (O).But, preferably at the scene from Pd
2Dba
3(CHCl
3) and phosphine generation catalyzer.Use 1mol% palladium-triphenylphosphine catalyzer, even the fluorinated alohol that is fit to of catalytic amount, can be to increase the allyl alcohol selectivity to 10 of formula 2A ': 1.The amount of increase formula 15c fluorinated alohol is further to 50mol% and 100mol%, and the isomery ketenes ratio that obtains the allyl alcohol of formula 2A ' and formula 13 respectively is the mixture of 16: 1 and 19: 1.
Wherein X is CH
3(formula 15a), H (formula 15b), phenyl (formula 15c), or CF
3(formula 15d).
Selectivity and fluorinated alohol pK have been found
aBetween relevant.PK
a<9 fluorinated alohol is effective especially.As shown in table 1, as the pK of additive
aBe reduced to 8.8 from 9.3, the selectivity of the allyl alcohol of required formula 2A ' sharply increases, and shows that different response paths relates to the protonated of equal alkaline intermediate.Other protonated source, as methyl alcohol, phenol and carboxylic acid can cause not reacting or incomplete reaction, may be owing to destroyed catalyzer.
Table 1: the pK of additive
aWith selectivity
The alcohol additive | ????Mol% | PK in the water a | % (formula 2A ' than formula 13) |
t-BuOH | ????100 | ????19 | ????25 |
MeC(CF 3) 2OH (formula 15a) | ????10 | ????9.51 | ????26 |
(CF 3) 2CHOH (formula 15b) | ????10 | ????9.13 | ????32 |
Ph(CF 3) 2OH (formula 15c) | ????10 | ????8.52 | ????91 |
(CF 3) 3COH (formula 15d) | ????10 | ????5.18 | ????95 |
Formula 16 | ????10 | ????8.48 | ????92 |
Although most of acid perfluoro-uncles-butanols (formula 15d) than the littler tart fluorinated alohol of formula 15c and formula 16 obtain better choice (formula 2A ' allyl alcohol and the isomery ketenes ratio of formula 13 be 95: 5), react cleaner with formula 15c and formula 16 than formula 15d.The fluorinated alohol of application formula 16, [original position is from the Pd of 0.5mol% by the palladium catalyst with 1mol%
2Dba
3(CHCl
3) preparation] and in weak polar solvent the alcohol of the formula 16 of (toluene), under 35 ℃ low temperature, react, can obtain better result (formula 2A ' allyl alcohol and the isomery ketenes ratio of formula 13 greater than 99: 1).This low-temp reaction has also increased the purity of reaction.
As mentioned above, with compound formula 1B ' (formula 1B ' be formula 1B, wherein R
1Be t-Bu, R
2Be TBS) and 7: 1 mixtures of compound formula 1*B ' (the Z type isomer of compound formula 1B ') carry out the reaction of palladium isoversion, obtain required formula 2B ' allyl alcohol (formula 2B ' be formula 2B, wherein R
1Be t-Bu, R
2Be TBS) 88: 12 mixture of corresponding ketone with it (seeing the following form).Therefore, regioselectivity depends on the stereochemistry of allene oxide thing.Isomer 1B (E-isomer) and 1*B (Z-isomer) can pass through chromatographic separation.From pure E-isomer 1B, but high selectivity ground (>99%) obtains required allyl alcohol (formula 2B ' and formula 2B ").On the other hand, (Z)-allene oxide thing 1*B optionally produces ketone 13 and 14.The ethyl and the tertiary butyl also can obtain similar result.
????R 1(substrate) | The E of substrate: Z | The E of product: Z | Allyl alcohol: ketone |
????Et(1B’+1*B’) ????Et(1B’+1*B’) ????Et(1B’+1*B’) ????Et(1B’) ????Et(1*B’) | Had only E to have only Z in 4: 17: 19: 1 | Have only E (2B ') to have only E (2B ') to have only E (2B ') to have only E (2B ') to have only E (2B ') | ????80∶20(2B’∶14) ????88∶12(2B’∶14) ????90∶10(2B’∶14) ????>99∶1(2B’∶14) ????14∶86(2B’∶14) |
????t-Bu(1B”) ????t-Bu(1*B”) | Have only E to have only Z | Have only E (2B ") to have only E (2B ") | ????>99∶1(2B”∶13) ????8∶92(2B”∶13) |
Although can obtain E-isomer formula 1B in high selectivity ground (>99%), under commercial terms, it may be unpractiaca separating E-isomer formula 1B from Z-isomer 1*B.Therefore, with the open loop of E/Z-isomer epoxide, carry out exchange of solvent with DMF afterwards in fact usually, allyl alcohol the 2B '/2B that obtains " and the mixture of ketone 14/13 carry out silylanizing.Tert-butyldimethylsilyl chloride and imidazoles are used in silylanizing, adopt known resist technology to obtain.Other silyl blocking group; as trimethyl silyl; triethylsilyl; the tripropyl silyl; the triisopropyl silyl, dimethyl hexyl silyl, triphenyl silyl; can use equally with the t-butyldiphenylsilyl blocking group, corresponding silyl chloride is reacted with pure formula 2B.Because pure 2B '/2B " change into nonpolar product by silylanizing, and polar ketone keeps not becoming, pure silylated product can be separated by filtered through silica gel at an easy rate.
Carry out following embodiment, to explain the present invention.For those of ordinary skills, according to differential responses shown in this article path, embodiment is changed, prepare related compound, all be clearly.
Embodiment 1: the preparation of formula 2A ' allyl alcohol
At room temperature, the product of this reaction can carry out the Diels-Alder dimerization as strong solution or in solid phase.Therefore, should store down at-20 ℃.
Be furnished with among the 500mL, three neck round-bottomed flasks of magnetic stirring apparatus, partition plug, thermometer, add 570mg (0.551mmol) three (dibenzalacetones), two palladiums (O)-chloroform adducts, and 1.45g (5.55mmol) triphenylphosphine.Emptying flask air recharges three times with nitrogen, adds 35mL toluene by syringe then.The intense violet color mixture that obtains stirred 1 hour at ambient temperature, obtained yellow thin pulp.Then, add 1 of 0.54mL (2.18mmol), 3-two (1,1,1,3,3,3-hexafluoro-2-hydroxypropyl) benzene.That thin pulp becomes is red-and orange.Stir after 3 minutes, under envrionment temperature (19 ℃), with 40.7g (110mmol, in theory) be dissolved in formula 1A ' crude product compound in the 160mL toluene (according to the similar method preparation of the above-described catalyst solution (flask that promptly contains formula 1A ' crude product compound, evacuation of air recharges three times with nitrogen, adds toluene by syringe then)), use the nitrogen of malleation a little by sleeve pipe, join in the catalyst solution that obtains above.Under the nitrogen of malleation a little, stirred at ambient temperature 10 minutes, reaction mixture is heated to 32 ℃ spends the night (15 hours), following 2 hours at 35 ℃ then.Reaction mixture 25 ℃ (bath temperature), decompression (oil pump) in rotatory evaporator are concentrated down rapidly, and residue under high vacuum dry 30 minutes obtains 44.8g (overweight) blush oily formula 2A ' crude product compound.This material can be directly used in next step reaction without being further purified, described in former document: Shiuey, S.-J; Kulesha, I.; Baggiolini, E.G.; Uskokovic, M.R. organic chemistry magazine (J.Org.Chem.), 1990,55,243.This material purity of HPLC analysis revealed is approximately 87%, has about 3% formula 2A ' compound starting raw material, the by product ketone less than 1% and about 3% dipolymer.
Carry out middle control: NMR (CDCl
3), TLC (3: 1 hexanes: ethyl acetate; Shortwave UV-detector and PMA dyeing; The R of formula 1A ' compound
f=0.74, the R of formula 2A ' compound
f=0.45, the R of ketone
f=0.50) and HPLC.
Describe as top program, reaction is preferably spent the night at 35 ℃, causes incomplete reaction (stirred 15 hours down at 32 ℃, at 35 ℃ after following 2 hours, observe about 3% starting raw material then).
Per-cent is at 220nm place respective peaks area percentage.The HPLC condition is as follows:
Post: Nucleosil5 μ m, 4.6 * 250mm
Moving phase: the hexane that contains 2% Virahol of flow velocity 0.5mL/min
Retention time: 7.6min (formula 1A ' compound), 8.8min (ketone by product), 8.9min (two
Benzylidene-acetone), and 12.1min (formula 2A ' compound), 18min (dipolymer).
Embodiment 2: the preparation of formula 3B ' diene-ester
Be furnished with in the 250mL round-bottomed flask of magnetic stirring apparatus, partition plug, thermopair and nitrogen scatterer, add 388mg (0.375mmol) three (dibenzalacetones), two palladiums (O)-chloroform adducts, and 985mg (3.75mmol) triphenylphosphine.Emptying flask air recharges three times with nitrogen, adds 23mL toluene by syringe then.The intense violet color mixture that obtains stirs 30min at ambient temperature, obtains greenish orange color contamination suspension.Then, add 1 of 370 μ L (1.5mmol), 3-two (1,1,1,3,3,3-hexafluoro-2-hydroxypropyl) benzene.That mixture becomes is red-and orange, the most solid dissolving.Stir after 3 minutes, under envrionment temperature (19 ℃), use the nitrogen of malleation a little by sleeve pipe, add 24.4g (74.9mmol) in the catalyst solution that obtains upward and be dissolved in formula 1B '/1*B ' crude product compound (E/Z 8.5: 1 in the 100mL toluene, according to preparing (the flask that contains formula 1B ' crude product compound with the similar method of above-described catalyst solution, evacuation of air recharges three times with nitrogen, adds toluene by syringe then)).Under the nitrogen of malleation a little, stirred at ambient temperature 10 minutes, reaction mixture is heated to 40 ℃ and spends the night (16 hours).TLC analysis revealed complete reaction.With reaction mixture in rotatory evaporator<40 ℃, decompression are down concentrated, remove most of toluene.The brown oil that obtains is dissolved among the 80mL DMF, and the solution that obtains cools off with ice-water bath, adds 6.12g (89.8mmol) imidazoles then, adds 13.5g (89.8mmol) tertiary butyl chloride dimethylsilane afterwards.After 10 minutes, remove cooling bath, at room temperature stir and spend the night.TLC analysis revealed complete reaction.Reaction mixture dilutes with the 300mL hexane, 2 * 150mL=300mL water washing.Merge water lotion, with behind 2 * 100mL=200mL hexane-extract, merging back-extracting solution is with 2 * 50mL=100mL water washing.Merge all organic phases, use dried over mgso, be concentrated into drying regime, obtain yellow viscous oil (35.6g, overweight).In the 100mL hexane, the solution that obtains is by the 200g filtered through silica gel with this material dissolves.Then with silicagel pad 98: 2 hexanes of 1.5L: ethyl acetate, merging filtrate and washings under reduced pressure are concentrated into drying regime, obtain 27.7g (84.0%) colorless oil formula 3B ' compound.
Carry out middle control: HPLC, NMR (CDCl
3), and TLC (3: 1 hexanes: ethyl acetate; Shortwave UV-detector and PMA dyeing; R
f3B '=0.9, R
f1B '=0.85, R
f2B '=0.45, R
f14=0.6, dibenzalacetone R
f=0.7,19: 1 hexanes: ethyl acetate; Shortwave UV-detector and PMA dyeing; The R of formula 3B ' compound
f=0.4, the R of 2B ' compound
f=0.1).
Preparation embodiment 1: the preparation of formula 4 ' epoxide
Be furnished with among the 2L, three neck round-bottomed flasks of mechanical stirrer, Dean-Stark thickener, addition funnel and nitrogen scatterer, add 207g (776mmol) formula 3 ' compound, 3.09g (11.7mmol) vanadyl acetylacetonate and 770mL hexanaphthene.With mixture heating up after gentle reflux, in 90 minutes, add 170mL (850-1020mmol) the 5.0-6.0M tert-butyl hydroperoxide be dissolved in the nonane.Along with green solution becomes in adding is a scarlet, gentle heat release takes place thereupon.Add finish after, with the orange that obtains-green solution reflux 3 hours.Volume of water increases about 4mL in the trap.The TLC analysis revealed is to there being a spot of starting raw material.After being lower than room temperature with ice-water bath cooling, add 77mL 1M sodium bisulfate and 150mL saturated sodium bicarbonate solution.After 5 minutes, the iodine-starch detection paper shows does not have superoxide to exist.Separate organic phase, use the washing of 3 * 150mL=450mL saturated sodium bicarbonate solution and 150mL saturated nacl aqueous solution then, use dried over mgso, decompression,<30 ℃ concentrated down.Further under the room temperature high vacuum dry 2 hours, obtain formula 4 ' the crude product compound that 247g (overweight) contains nonane, be faint yellow solid.
Preparation embodiment 2: the preparation of formula 5 ' ketone
Be furnished with in mechanical stirrer, the 3L that leads to nitrogen tube and escape pipe, the three neck round-bottomed flasks, add 247g (approximately 776mmol) formula 4 ' compound, 24g (286mmol) sodium bicarbonate and 1.8L methyl alcohol.Mixture is placed one in the logical nitrogen tube and is had the gas diffusion tube (25-50 μ) at sintered glass tip with after the dry ice/acetone batch cooling, and by a trap, escape pipe is connected in the pipe that is immersed in 1M liquor kalii iodide (2L) (4mm internal diameter).Then, under-70 ℃, continuously ozonized air is passed in the reaction mixture.After 5 hours, reaction becomes sky-blue.Ozonized air feeds mixture after 15 minutes again to subtract flow velocity 1LPM, cleans by air (4LPM) and removes excessive ozone in 25 minutes.The white suspension that obtains is handled with 75mL (1.02mol, about 1.3 equivalents) methyl-sulfide, is warming up to ambient temperature overnight then.The iodine-starch test paper shows does not have superoxide to exist.By removing by filter insoluble inorganic impurity, with the washing of 100mL ethyl acetate.Merging filtrate and washings under reduced pressure concentrate (bath temperature≤30 ℃), must remove all methyl alcohol.The yellow that obtains, emulsus residue distribute in 1L ethyl acetate and 300mL water.Separate water layer, use the 50mL ethyl acetate extraction.Merge organic phase, with the washing of 300mL saturated nacl aqueous solution, dried over mgso, decompression concentrates (bath temperature≤35 ℃) down.The light yellow oil that obtains is dissolved in the 150mL ethyl acetate, adds the 600mL hexane.The suspension that obtains store overnight in refrigerator.By solid collected by filtration, with cold 4 of 2 * 200mL=400mL; 1 hexane: the ethyl acetate washing by the drying of bleeding, obtains the white solid (mp 92-94 ℃) of 155.9g (in 68.5% 3 step) formula 5 ' then under the high vacuum room temperature.Merge mother liquor and washings, with 3 * 100mL=300mL saturated sodium bicarbonate solution and the washing of 100mL saturated nacl aqueous solution, dried over mgso, decompression concentrated down (bath temperature≤35 ℃).Residue adds the 280mL hexane with the dilution of 40mL ethyl acetate.The little muddy liquid store overnight in refrigerator that obtains.By solid collected by filtration, with cold 7: 1 hexanes of 4 * 40mL=160mL: the ethyl acetate washing by the drying of bleeding, obtains the white solid (mp 91-93 ℃) of second group of formula 5 ' of 18.3g (in 8.0% 3 step) then under the high vacuum room temperature.Merge two groups, ultimate production is 174g (in 76.5% 3 step) formula a 5 ' compound.
Carry out middle control: NMR (CDCl
3), and TLC (1: 1 hexane: ethyl acetate; PMA dyeing; The R of formula 4 ' compound
f=0.70, the R of formula 5 ' compound
f=0.50).
Preparation embodiment 3: the preparation of formula 6 ' acetic ester
Be furnished with among the 2L, three neck round-bottomed flasks of mechanical stirrer, nitrogen scatterer, thermometer, add 82.2g (289mmol) formula 5 ' compound, 91% metachloroperbenzoic acid and 3: 1 hexane-ethyl acetate of 840mL of 115g (606mmol, 2.1 equivalents).White suspension stirred 3 days down in room temperature (about 20 ℃).NMR analysis revealed about 98% transforms.After being cooled to 5 ℃ with ice-water bath, in≤12 ℃, 8 minutes, dropwise add 145mL (435mmol) 2.5M salt of wormwood.Then, 180mL (360mmol) 2M sodium sulfite solution in 25 fens kinds, the temperature of keeping mixture simultaneously is lower than 12 ℃.Remove cooling bath, mixture stirred 90 minutes at ambient temperature.The NMR analysis revealed of organic phase exists mCPBA and 1: 4 mixture of product.Therefore add 6mL (82mmol) methyl-sulfide.Obtain suspension and stir after 15 minutes, the iodine-starch test paper shows complete reaction.By solids removed by filtration, with the washing of 100mL ethyl acetate.Merging filtrate and washings are separated.Organic phase is washed with 30mL 10% potassium bicarbonate solution, dried over mgso.Merge water, use the 200mL ethyl acetate extraction.Organic phase is washed with 20mL 10% potassium bicarbonate solution, dried over mgso.Merge water, once or several times with the 200mL ethyl acetate extraction.Organic phase is washed with 20mL 10% potassium bicarbonate solution, dried over mgso.Merge all organic phases, under≤30 ℃, decompression, concentrate.Residue is dry under high vacuum, room temperature, obtains 81.3g (93.6%) colorless oil formula 6 ' compound.There is the formula 5 ' compound of a spot of ethyl acetate and trace in the NMR analysis revealed.
Carry out middle control: NMR (CDCl
3), and TLC (1: 1 hexane: ethyl acetate; PMA dyeing; The R of formula 5 ' compound
f=0.50, the R of formula 6 ' compound
f=0.55).
Preparation embodiment 4: the preparation of formula 7 ' alcohol
Be furnished with among the 1L, round-bottomed flask of magnetic stirring apparatus, nitrogen scatterer and addition funnel, add 81.3g (270mmol) formula 6 ' compound and 270mL methyl alcohol.The solution that obtains cools off with ice-water bath, stirs 30 minutes, dropwise adds 9.3mL (40.5mmol, methanol solution of sodium methylate 15mol%) in 10 minutes.After stirring 4 hours under 0 ℃, TLC analysis revealed complete reaction.Reaction mixture quenches with 3.0mL (52.6mmol, 1.3 equivalent sodium methylates) acetate, concentrates under≤30 ℃, decompression.The emulsus residue that obtains is dry under high vacuum, room temperature, distributes in 500mL ethyl acetate and 50mL 5% potassium bicarbonate solution then.Be separated, organic phase is washed with 50mL 5% potassium bicarbonate solution and 50mL saturated nacl aqueous solution.Merge water, with 2 * 100ml=200mL ethyl acetate extraction.Merge organic phase, use dried over mgso, at≤35 ℃ of following concentrating under reduced pressure.The light yellow oil that obtains (approximately 76g) is dissolved in the 70mL ethyl acetate, by adding the crystal seed induced crystallization.Then, add the 350mL hexane gradually.The suspension that obtains is at room temperature placed and is spent the night.By solid collected by filtration, with cold 5: 1 hexanes of 2 * 70mL=140mL: the ethyl acetate washing by the drying of bleeding, obtains the white solid (mp 91-92 ℃) of 54.8g (78.4%) formula 7 ' compound then under the high vacuum room temperature.Merge mother liquor and washings, with the dilution of 300mL hexane, store overnight in refrigeration chamber.Remove supernatant liquid by decant, residue is dissolved in the 100mL ethyl acetate.Solution use dried over mgso with the washing of 20mL 5% potassium bicarbonate solution and 200mL saturated nacl aqueous solution, under reduced pressure concentrated (bath temperature≤35 ℃).Residue (4.3g) is dissolved in the 5mL ethyl acetate, after adding the crystal seed induced crystallization, adds the 25mL hexane gradually.The suspension that obtains was placed 4 hours.By solid collected by filtration, use cold 5: 1 hexanes of 12mL: the ethyl acetate washing by the drying of bleeding, obtains the white solid (mp 90-92 ℃) of (3.6%) second group of formula 7 ' compound of 2.5g then under the high vacuum room temperature.Merge two groups, ultimate production is 57.3g (in 76.7% liang of step) formula a 7 ' compound.
Carry out middle control: NMR (CDCl
3), and TLC (1: 1 hexane: ethyl acetate; PMA dyeing; The R of formula 6 ' compound
f=0.55, the R of formula 7 ' compound
f=0.25).
Preparation embodiment 5: the preparation of formula 8 ' silyl ether
Be furnished with among the 250mL, three neck round-bottomed flasks of mechanical stirrer, thermometer and nitrogen scatterer, add 28.6g (111mmol) formula 7 ' compound, 20.5g (301mmol) imidazoles, 19.6g (130mmol) tertiary butyl chloride dimethylsilane and 170mL tetrahydrofuran (THF).Initial gentle heat release (10-12 ℃) weakens rapidly.Mixture stirs under nitrogen and spends the night.TLC analysis revealed complete reaction.By using the sintered glass funnel solids removed by filtration, wash fully with the 200mL tetrahydrofuran (THF).Merge colourless filtrate and washings, decompression, 25 ℃ of following concentrating, high vacuum is 30 minutes then, obtains 48.7g (overweight) formula 8 ' crude product compound white solid.
1There is about 1 normal protonated imidazoles in H NMR analysis revealed.This material can be directly used in next step without any purifying.
Carry out middle control: NMR (CDCl
3), and TLC (1: 1 hexane: ethyl acetate; PMA dyeing; The R of formula 7 ' compound
f=0.16, the R of formula 8 ' compound
f=0.79).
Preparation embodiment 6: the preparation of formula 1A ' unsaturated ester
Be furnished with among the 500mL, three neck round-bottomed flasks of mechanical stirrer, thermometer and nitrogen scatterer, add 136mL (1.68mol) pyridine.Once add 13.6mL (186mmol) thionyl chloride then.Initial heat release to 27 ℃ weakens subsequently, and solution stirred 40 minutes at ambient temperature.The yellow solution that obtains is cooled to-34 ℃ then, (such speed maintains temperature of reaction to be lower than-25 ℃ for 111mmol, formula 8 ' crude product compound solution in theory) dropwise to add the 48.7g be dissolved in the 86mL tetrahydrofuran (THF) in 1 hour.Then reaction mixture was warming up to 0 ℃ in 100 minutes, pours into then in the mixed solution of 700mL saturated sodium bicarbonate solution and 350mL hexane.The mixture that obtains was stirred 30 minutes, up to there not being tangible gas to generate.Separate hexane layer, with the washing of 350mL 1M citric acid solution, dried over mgso under reduced pressure is concentrated into drying regime, obtain 40.7g (overweight) colorless oil formula 1A ' compound (
1H NMR analyzes about 90% purity.This material can be directly used in next step without any purifying.
Carry out middle control: NMR (CDCl
3), and TLC (9: 1 hexanes: ethyl acetate; Shortwave UV-detector and PMA dyeing; The R of formula 8 ' compound
f=0.04, the R of formula 1A ' compound
f=0.21).
Preparation embodiment 7: the preparation of formula 10 Peracetic Acid esters
Be furnished with in mechanical stirrer, thermometer, the 500mL that leads to nitrogen tube and escape pipe, the three neck round-bottomed flasks, add 20.0g (120mmol) formula 9 compounds, 20mL (494mmol) methyl alcohol and 200mL methylene dichloride.After mixture is cooled to-68 ℃ with dry ice/acetone batch, place one in the logical nitrogen tube and have the gas diffusion tube (25-50 μ) at sintered glass tip, by a trap, escape pipe is connected in the pipe that is immersed in 1M liquor kalii iodide (2L) (4mm internal diameter).Then, under-68 ± 3 ℃, continuously ozonized air (4.5LPM) is passed in the reaction mixture.After 65 minutes, reaction becomes sky-blue, shows complete reaction.Remove excessive ozone in 30 minutes by the nitrogen washing, obtain colourless solution.Nitrogen scatterer and another funnel are housed in the escape pipe.In 40 minutes, mixture is warming up to 14 ℃.With dry ice-propanone bathe be cooled to-25 ℃ after, in 5 minutes, add 117mL (839mmol) triethylamine, keep mixture temperature simultaneously and be lower than-25 ℃.Then, once add 2.0g (16.4mmol) dimethyl aminopyridine (DMPA), in 10 minutes, slowly add 79.6mL (843mmol) diacetyl oxide, keep temperature of reaction simultaneously between-25 ℃ and-38 ℃.Mixture was warming up to-8 ℃ in 30 minutes, stirred 1.5 hours down at-7 ± 1 ℃.The TLC analysis revealed is complete reaction.Reaction mixture is quenched by slowly adding (in 7 minutes) 33mL methyl alcohol, keep mixture temperature simultaneously and be lower than 10 ℃.After stirring 5 minutes under 5 ℃, mixture dilutes with the 220mL hexane, with 2 * 150mL=300mL, 10% citric acid solution and 2 * 80mL=160mL saturated potassium hydrogen carbonate solution washing, dried over mgso, under 35 ℃ of decompressions, be concentrated into drying regime, obtain 38.2g (overweight) yellow oily formula 10 crude product compounds.This material can be directly used in next step without any purifying.
Carry out middle control: NMR (CDCl
3), and TLC (2: 1 hexanes: ethyl acetate; PMA dyeing; The R of formula 9 compounds
f=0.80, the R of formula 9C compound
f=0.45,40: 2: 1 methylene dichloride: ethyl acetate: methyl alcohol; PMA dyeing; The R of formula 9C compound
f=0.40, the R of formula 10 compounds
f=0.80).
Preparation embodiment 8: the preparation of formula 12 ' ketone
Be furnished with in the 500mL round-bottomed flask of magnetic stirring apparatus, thermometer, nitrogen scatterer, add 38.2g (120mmol) formula 10 compounds, 2g (24.4mmol) sodium acetate and 245mL methyl alcohol.Stir under 37 ℃ and spend the night, the TLC analysis revealed is complete reaction.Like this, mixture is concentrated into drying regime under 39 ℃, and residue (29g) is dissolved in the 40mL acetonitrile.The solution that obtains is concentrated into drying regime under 35 ℃ of decompressions, add the 40mL acetonitrile.The solution that obtains is concentrated into drying regime once more under 35 ℃ of decompressions, add 35mL acetonitrile and 29.5g (433mmol) imidazoles.After the ice-water bath cooling, add 32.6g (217mmol) tertiary butyl chloride dimethylsilane.Remove ice-water bath, mixture at room temperature stirred 4 hours.Only there is the starting raw material of trace in the TLC analysis revealed.By adding 10mL methyl alcohol quenching reaction mixture.Gentle heat release raises 2 ℃ mixture temperature.Stir after 5 minutes, add the 55mL frozen water, mixture is with 2 * 50mL=100mL hexane extraction.Merge organic phase, use 2: 3 methyl alcohol of 50mL: water washing, dried over mgso is concentrated into drying regime under 40 ℃ of decompressions.Further dry residue is 1 hour under 46 ℃ and 0.4mmHg, obtains light yellow oily formula 12 ' the crude product compound of 25.2g.This material can be directly used in next step without any purifying.
Carry out middle control: NMR (CDCl
3), and TLC (40: 2: 1 methylene dichloride: ethyl acetate: methyl alcohol; PMA dyeing; The R of formula 10 compounds
f=0.8, the R of formula 11 compounds
f=0.4, the R of formula 12 ' compound
f=0.95,8: 1 hexanes: ethyl acetate; PMA dyeing; The R of formula 12 ' compound
f=0.6, the R of tertiary butyl dimethylsilane
f=0.5).
Preparation embodiment 9: the preparation of formula 1B ' unsaturated ester
Be furnished with among the 250mL, three neck round-bottomed flasks of mechanical stirrer, thickener, thermometer and nitrogen scatterer, add 1.41g (177mmol) lithium hydride, 43.3mL (216mmol) triethyl phosphine acyl acetic acid ester and 45mL THF.Mixture slowly is heated to 55 ℃, removes heating bath.Heat release made the temperature of mixture be increased to 69 ℃ in 5 minutes.The temperature of mixture slowly dropped to 66 ℃ in 55 minutes, obtain settled solution.By distilling under the decompression a little, remove about 25mL THF then at 50-55 ℃.After the mixture that obtains is cooled to 3 ℃ with frozen water, disposable adding 25.2g (98.4mmol) formula 12 ' crude product compound.Funnel joins bleaching liquor in the reaction mixture with 15mL THF rinsing.Reaction mixture was stirred 90 minutes down at 5-6 ℃, and 11 ℃ were stirred 18 hours down, and 24 ℃ were stirred 2 hours down.The TLC analysis revealed is complete reaction.Mixture 8: 1 hexanes of 100mL: the ethyl acetate dilution with 3 * 36mL=108mL water washing, is concentrated into drying regime under 38 ℃ of decompressions.Residue is dissolved in the 115mL hexane, and by 50g TLC filtered through silica gel, silicagel pad 8: 1 hexanes of 191mL: the ethyl acetate washing, merging filtrate and washings are concentrated into drying regime under 37 ℃ of decompressions.Residue under high vacuum further dry 1 hour obtains 24.4g (76.1%) yellow oily formula 1B ' compound.
1This material of H NMR analysis revealed is 8.5: 1 a mixture of 1B ' compound Z-isomer corresponding with it (formula 1*B ' compound).This material can be directly used in next step without any purifying.
Carry out middle control: NMR (CDCl
3), and TLC (3: 1 methylene dichloride: hexane; Shortwave UV-detector and PMA dyeing; The R of formula 12 ' compound
f=0.55, the R of formula 1B ' compound
f=0.45, the R of Z-isomer (formula 1*B ' compound)
f=0.35).
Run through the present invention and describe in detail, for those skilled in the art, other different embodiments are clearly.These changes are considered within the scope and spirit of the invention, and are limited by following claim and their Equivalent.
Claims (12)
3. the compound that has the following formula structure:
R wherein
1Be C
1-C
6Alkyl; With
R
2For being selected from down the hydroxy-protective group of group: trimethyl silyl, triethylsilyl, tripropyl silyl, the triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl; Or its enantiomer.
7. the compound that has the following formula structure:
Or its enantiomer.
9. the compound that has the following formula structure:
R wherein
2For being selected from down the hydroxy-protective group of group: trimethyl silyl, triethylsilyl, tripropyl silyl, the triisopropyl silyl, t-butyldimethylsilyl, dimethyl hexyl silyl, triphenyl silyl, and t-butyldiphenylsilyl; Or its enantiomer.
10. the compound that has the following formula structure:
R wherein
1Be C
1-C
6Alkyl; Or its enantiomer.
12. have the compound of following formula structure:
R wherein
1Be C
1-C
6Alkyl; Or its enantiomer.
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US15037899P | 1999-08-23 | 1999-08-23 | |
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US60/150,226 | 1999-08-23 |
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CNB001238655A Expired - Fee Related CN1179938C (en) | 1999-08-23 | 2000-08-23 | Process for producing vitamin D analogue |
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EP (1) | EP1078931B1 (en) |
JP (1) | JP3517391B2 (en) |
KR (1) | KR100369881B1 (en) |
CN (2) | CN1269808C (en) |
AT (1) | ATE319722T1 (en) |
CA (1) | CA2316157C (en) |
DE (1) | DE60026407T2 (en) |
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WO2015045739A1 (en) * | 2013-09-25 | 2015-04-02 | Jsr株式会社 | Radiation-sensitive resin composition, method for forming resist pattern, polymer, and compound |
CN112724060B (en) * | 2021-01-15 | 2022-10-21 | 常州博海威医药科技股份有限公司 | Novel process for producing prostaglandin and intermediate |
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CA2316157C (en) | 2004-11-23 |
CN1287115A (en) | 2001-03-14 |
KR20010071114A (en) | 2001-07-28 |
DE60026407T2 (en) | 2006-11-09 |
CN1179938C (en) | 2004-12-15 |
MXPA00008175A (en) | 2002-08-06 |
ES2258432T3 (en) | 2006-09-01 |
EP1078931A2 (en) | 2001-02-28 |
EP1078931B1 (en) | 2006-03-08 |
CN1269808C (en) | 2006-08-16 |
KR100369881B1 (en) | 2003-01-30 |
JP2001122882A (en) | 2001-05-08 |
CA2316157A1 (en) | 2001-02-23 |
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