CN1554424A - Strong urea nitrogen adsorbent and its preparing method - Google Patents
Strong urea nitrogen adsorbent and its preparing method Download PDFInfo
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- CN1554424A CN1554424A CNA200310122154XA CN200310122154A CN1554424A CN 1554424 A CN1554424 A CN 1554424A CN A200310122154X A CNA200310122154X A CN A200310122154XA CN 200310122154 A CN200310122154 A CN 200310122154A CN 1554424 A CN1554424 A CN 1554424A
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- dialdehyde
- urea nitrogen
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Abstract
The powerful urea nitrogen adsorbent as a kind of uraemia treating medicine is prepared with dialdehyde cellulose, aldehyde coated cellulose, dialdehyde cellulose with activated surface or aldehyde coated cellulose with activated surface of 25-85% hydroformylation; and bean powder or emulsion containing urease matter in certain weight ratio and through mixing. The preparation process includes the activation of dialdehyde cellulose or aldehyde coated cellulose; preparation of bean powder or emulsion; and mixing. The urea nitrogen adsorbent of the present invention has adsorption capacity as high as 18 times that of aldehyde coated oxy-starch, no side effect, low cost and simple preparation process.
Description
Technical field
The invention relates to a kind of strong urea nitrogen absorber and preparation method thereof, belong to the treatment uremia.
Background technology
Chronic renal failure (CRF) is that a kind of prognosis is not good, the disease of serious threat patient life.Oral adsorbent is a kind of active and effective Therapeutic Method, and its principle is that the adsorbent under the clothes is behind the intestines and stomach of human body, absorption is accumulated in intravital uremic thing, excrete together in company with feces, alleviate uremic symptom, suppress the purpose that the state of an illness further worsens thereby can reach.
The present domestic oral adsorbent of producing blood urea nitrogen mainly is a Coated Aldehyde Oxystarch, and this oral adsorbent effective percentage reaches more than 80%, obtains the trust of extensive patients.But a little less than the absorbability of this adsorbent, be 0.38-0.41mgN/g at the 6-8h absorbability, unsatisfactory.
Summary of the invention
The object of the present invention is to provide a kind of strong urea nitrogen absorber and preparation method thereof, not only to the blood urea nitrogen high adsorption capacity, and its preparation technology is simple as oral agents for this adsorbent.
The present invention is realized by following technical proposals, the blood urea nitrogen adsorbent that is used for the treatment of uremic oral tablet or wafer, it is characterized in that, the component of this adsorbent and weight ratio content are: aldehyde radicalization account for the dialdehyde cellulose of 25-85% or cover the aldehyde cellulose or the dialdehyde cellulose of surface active or surface active cover the aldehyde cellulose: 5-300 part contains 1 part of at least a Semen Glycines powder in the Semen Canavaliae, Semen sojae atricolor, Semen phaseoli radiati of urease or soyabean milk liquid (emulsion is in solid content).
The above-mentioned aldehyde cellulose that covers is the dialdehyde cellulose that the surface is covered with gelatin, chitosan, cellulose or methylcellulose.
The dialdehyde cellulose of above-mentioned surface active and to cover the aldehyde cellulose be through the swollen dialdehyde cellulose of the pure water of pH=5-8 and cover the aldehyde cellulose.
Above-mentioned dialdehyde cellulose is the microcrystalline Cellulose and the alpha-cellulose of dialdehyde-based.
The above-mentioned Semen Glycines powder that contains urease is a 40-60 order powder body.
The above-mentioned soyabean milk liquid that contains urease is that solid content is the emulsion of 10-50%.
Above-mentioned its process of preparation of adsorbent method comprises dialdehyde cellulose or covers the cellulosic activation processing of aldehyde, Semen Glycines powder or emulsion preparation and batch mixing preparation, it is characterized in that, activation processing is with dialdehyde cellulose or covers in the pure water that the aldehyde cellulose is dissolved in pH=5-8, under 30-80 ℃, carry out swelling, carry out solid-liquid separation then, the solid phase after the separation gets the dialdehyde cellulose of surface active or covers the aldehyde cellulose in lyophilization below 10 ℃.
The invention has the advantages that high adsorption capacity is 6.89-7.73mgN/g at the 6-8h absorbability, its absorbability is more than 18 times of Coated Aldehyde Oxystarch absorbability, and in addition, adsorbent of the present invention has no side effect, the making raw material sources are convenient, low price, and technology is simple.
The specific embodiment
Example 1
The dialdehyde-based microcrystalline Cellulose of 100g aldehyde radical ratio 50% adds and contains in the 1.5L distilled water of 3.2g gelatin, and temperature is controlled at 30 ℃, insulation 2.5h.Insulation finishes, and adds 95% ethanol 150mL and continues to stir 0.5h, leaves standstill 0.5h, filters.Dry back material is crossed 20 mesh sieves, the gelatin that obtains covers in the 500mL pure water that the aldehyde cellulose is dispersed in pH=7, stir 3h at 50 ℃, carry out solid-liquid separation, solid phase lyophilization under 8 ℃ of conditions, moisture 12% 98g activity is covered the aldehyde cellulose, add 50 purpose Semen Canavaliae powder 2g then, behind the uniform mixing, be dispersed into 200 capsules oral agents.
Example 2
The dialdehyde-based alpha-cellulose of 200g aldehyde radical ratio 55% is dispersed in the 800mL pure water of pH=6, stir 2.5h at 55 ℃, carry out solid-liquid separation, solid phase lyophilization under 6 ℃ of conditions, obtain moisture 10% the active dialdehyde cellulose of 197g, add 60 purpose Semen sojae atricolor powder 3g then, behind the uniform mixing, be dispersed into 400 capsules oral agents.
Example 3
The dialdehyde-based microcrystalline Cellulose of 200g aldehyde radical ratio 55% adds and contains in the 2.0L distilled water of 6.2g chitosan, and temperature is controlled at 32 ℃, insulation 3.5h.Insulation finishes, and adds 75% ethanol 200mL and continues to stir 0.5h, leaves standstill 5h, filters.Dry back material is crossed 20 mesh sieves, and the chitosan that obtains covers the aldehyde cellulose, and the last solid content of sprinkling is 10% 20mL Semen phaseoli radiati emulsion equably, and coccoid 200g is produced in lyophilization under 5 ℃ of conditions then, is dispersed into 400 capsules oral agents.
Example 4
The dialdehyde-based alpha-cellulose of 500g aldehyde radical ratio 70% adds and contains in the cellulosic 1.5L distilled water of 3.2g, and temperature is controlled at 33 ℃, insulation 2.0h.Insulation finishes, and adds 85%7 pure 200mL and continues to stir 0.5h, leaves standstill 0.5h, filters.Dry back material is crossed 20 mesh sieves, obtains covering the aldehyde cellulose, and the last solid content of sprinkling is 20% 50mL Semen Canavaliae emulsion equably, and coccoid 510g is produced in lyophilization under 4 ℃ of conditions then, is dispersed into 400 capsules oral agents.
Example 5
The dialdehyde-based microcrystalline Cellulose of 200g aldehyde radical ratio 70% is dispersed in the 500mL pure water of pH=6, stir 2h at 50 ℃, carry out solid-liquid separation, again solid phase lyophilization under 6 ℃ of conditions, obtain moisture 10% 198g dialdehyde cellulose, add 60 purpose Semen Canavaliae powder 2g then, behind the uniform mixing, be dispersed into 400 capsules oral agents.
Example 6
On the dialdehyde-based alpha-cellulose 200g of aldehyde radical ratio 50%, the last solid content of sprinkling is 10% 20mL soya emulsion equably, and coccoid 202g powder body is produced in lyophilization under 5 ℃ of conditions then, is distributed into 404 capsules oral agents.
Claims (7)
1. strong urea nitrogen absorber, be used for the treatment of uremic oral tablet or wafer, it is characterized in that: the component of this adsorbent and weight ratio content are: aldehyde radicalization account for the dialdehyde cellulose of 25-85% or cover the aldehyde cellulose or the dialdehyde cellulose of surface active or surface active cover the aldehyde cellulose: 5-300 part; Contain 1 part of at least a Semen Glycines powder in the Semen Canavaliae, Semen sojae atricolor, Semen phaseoli radiati of urease or soyabean milk liquid.
2. by the described strong urea nitrogen absorber of claim 1, it is characterized in that: covering the aldehyde cellulose is the dialdehyde cellulose that the surface is covered with gelatin, chitosan, cellulose or methylcellulose.
3. by the described strong urea nitrogen absorber of claim 1, it is characterized in that: the dialdehyde cellulose of surface active and to cover the aldehyde cellulose be through the swollen dialdehyde cellulose of the pure water of pH=5-8 and cover the aldehyde cellulose.
4. by the described strong urea nitrogen absorber of claim 1, it is characterized in that: dialdehyde cellulose is the microcrystalline Cellulose and the alpha-cellulose of dialdehyde-based.
5. by the described strong urea nitrogen absorber of claim 1, it is characterized in that: the Semen Glycines powder that contains urease is a 40-60 order powder body.
6. by the described strong urea nitrogen absorber of claim 1, it is characterized in that: the soyabean milk liquid that contains urease is that solid content is the emulsion of 10-50%.
7. preparation method by the described strong urea nitrogen absorber of claim 1, this preparation method comprises dialdehyde cellulose or covers the cellulosic activation processing of aldehyde, Semen Glycines powder or the preparation of soyabean milk liquid and batch mixing preparation, it is characterized in that: activation processing is with dialdehyde cellulose or covers in the pure water that the aldehyde cellulose is dissolved in pH=5-8, under 30-80 ℃, carry out swelling, carry out solid-liquid separation then, solid phase after the separation gets the dialdehyde cellulose of surface active or covers the aldehyde cellulose in lyophilization below 10 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310122154XA CN1554424A (en) | 2003-12-29 | 2003-12-29 | Strong urea nitrogen adsorbent and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200310122154XA CN1554424A (en) | 2003-12-29 | 2003-12-29 | Strong urea nitrogen adsorbent and its preparing method |
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| Publication Number | Publication Date |
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| CN1554424A true CN1554424A (en) | 2004-12-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA200310122154XA Pending CN1554424A (en) | 2003-12-29 | 2003-12-29 | Strong urea nitrogen adsorbent and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103228677A (en) * | 2010-12-09 | 2013-07-31 | 通用电气公司 | Cellulose substrates, compositions and methods for storage and analysis of biological materials |
| CN104434954A (en) * | 2014-11-10 | 2015-03-25 | 苏州维泰生物技术有限公司 | Middle molecular adsorbent for uremia and preparation method of middle molecular adsorbent |
-
2003
- 2003-12-29 CN CNA200310122154XA patent/CN1554424A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103228677A (en) * | 2010-12-09 | 2013-07-31 | 通用电气公司 | Cellulose substrates, compositions and methods for storage and analysis of biological materials |
| CN104434954A (en) * | 2014-11-10 | 2015-03-25 | 苏州维泰生物技术有限公司 | Middle molecular adsorbent for uremia and preparation method of middle molecular adsorbent |
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