CN1552435A

CN1552435A - Medicine for preventing tumour

Info

Publication number: CN1552435A
Application number: CNA031122302A
Authority: CN
Inventors: 张金铎; 张永; 王美岭
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-06-03
Filing date: 2003-06-03
Publication date: 2004-12-08

Abstract

A Chinese medicine for preventing and treating tumor and arthritis is prepared from 4 Chinese-medicinal materials: flavescent sophora root, turmeric, zedoary and ganoderma through extracting, proportional mixing, pulverizing, sieving and granulating. Its advantage is high curative effect.

Description

A kind of medicine of anti-curing oncoma

Affiliated technical field

The present invention relates to the pharmaceutical composition of a kind of prevention and treatment tumor, particularly a kind of is the medicine of a kind of anti-curing oncoma of raw material with vegetable Chinese herbal medicine or its extract.

Background technology

Tumor is a kind of commonly encountered diseases and frequently-occurring disease, also is a kind of difficult disease that is difficult to treat simultaneously, is one of principal element of the rate of causing death.Therefore, research prevention and treatment anti-tumor medicine become the task of top priority.In recent years, Chinese medicine has been obtained certain progress having carried out series of experiment research and clinical application research aspect this disease of control, has shown the advantage of Chinese medicine.

Radix Sophorae Flavescentis mainly contains matrine, matrine has been developed into the Matelin Gnhusheye injection now, clinical practice treatment tumor, effect is obvious, this mainly is because matrine can make the inscribe collection of illustrative plates occurrence characteristics of the λ DNA of known nucleic acid sequence sexually revise, to reach the effect that suppresses tumor growth, matrine also has the effect of cell death inducing simultaneously, can suppress neoplasm metastasis.The generation of Induced by Matrine interferon improves immunologic function, to reach the effect that suppresses tumor.

The main component of Rhizoma Curcumae Longae is curcumin (curcumin), and curcumin is effective anti-mutation agent, also is the anti-promoting agent, and the state-run institute of oncology of the U.S. has classified it as third generation cancer chemoprevention medicine.Curcumin has very strong antioxidation, can eliminate intravital free radical, to reach the effect of prophylaxis of tumours.

Rhizoma Curcumae contains volatile oil, and this volatile oil has antineoplastic action through the animal experiment proof, clinically with calabash art spindle agent treatment tumor.

Ganoderma contains the sesame polysaccharide, and it can be grown and cancer cell specific induction of apoptosis by anticancer, can work in coordination with chemicotherapy, and the treatment tumor to protect positive convention function, alleviates the toxic and side effects of chemicotherapy.Ganoderan can the human body immunity improving function, stimulates body to produce interferon and tumor necrosis factor, cancer cell specific induction of apoptosis.It can also anticancer telomerase and DNA topoisomerase, to reach the effect that suppresses tumor.

More than four kinds of medicines all have the effect of anti-curing oncoma, but also do not have use in conjunction, subject matter is that the big young pathbreaker of the proportioning that each composition adopts directly influences the effect of its prevention and treatment of arthritis.

Summary of the invention

Purpose of the present invention overcomes above-mentioned deficiency exactly, and provides a kind of with these four kinds of medication combined application, anti-curing oncoma, and than single medicine good effect, the pharmaceutical composition that effect is fast.

Solution of the present invention is to be based upon on the basis that studies for a long period of time of Chinese medicine to tumor invasion mechanism, with reference to the modern pharmacological research achievement, filters out from plant class Chinese herbal medicine anti-effective 4 drug regimens of curing oncoma.

Its technical scheme is the medicine of the anti-curing oncoma of this kind, it is characterized in that being made up of following components in weight percentage: Radix Sophorae Flavescentis extract accounts for 1-60%, and Rhizoma Curcumae Longae extract accounts for 1-60%, and Rhizoma Curcumae extract accounts for 1-30%, and Ganoderma extract accounts for 1-60%; Sieve is thoroughly mixed, pulverized to said components, and Chinese medicine preparation is made in pelletize.

Described preparation is capsule or electuary.

Further, described component is: Radix Sophorae Flavescentis extract accounts for 20-50%, and Rhizoma Curcumae Longae extract accounts for 20-50%, and Rhizoma Curcumae extract accounts for 10-30%, and Ganoderma extract accounts for 20-50%.

Its capsular compound method is to get by prescription to cover conopsea extraction, Rhizoma Curcumae Longae extract, small art extract, Ganoderma extract with mat, after mixed powder is broken to 80-100 order granularity, and pelletize, encapsulated.Every heavy 500mg of this product, day clothes 3 times, each 1.

The preparation method those skilled in the art of electuary are easy to preparation by said method.

More than the combination of four kinds of medicines, unite and play a role, have extraordinary curative effect for anti-curing arthritis.Now zoopery result and clinical experiment result openly are described as follows:

Example one, treatment tumor animal experiment, Kunming mouse is selected in experiment for use, presses down the tumor experiment routinely and carries out, and causes mice S ₁₈₀Sarcoma, mice Emhorn (EAC) solid tumor, gastric infusion, 1 time/day, the administration volume is 0.5g/, and matched group is only irritated stomach distilled water 0.5g/, and continuous 10 days, animal was put to death in last administration 24 hours, dissected the tumor piece and also weighed, the calculating cancer suppressing ratio.It is as follows to press down the tumor result.

Heavy (g) tumour inhibiting rate (%) of tumor model group tumor

S ₁₈₀Sarcoma matched group 1.81 ± 0.64-

Experimental group 0.90 ± 0.29 50.3

EAC solid tumor matched group 1.72 ± 0.61-

Experimental group 0.53 ± 0.33 69.22

Treatment clinical tumor experiment, tumour patient 90 examples (gastric cancer 36 examples, hepatocarcinoma 33 examples, pulmonary carcinoma 21 examples), produce effects 20 examples as a result, effective 28 examples, invalid 42 examples, total effective rate 53.3%.

This medicine dropped into clinical trial in 1999, and therapeutic effect is obvious, patient's popular welcome.

The specific embodiment

The medicament capsule of example 1, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 1, and Rhizoma Curcumae Longae extract accounts for 9, and Rhizoma Curcumae extract accounts for 30, and Ganoderma extract accounts for 60; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 2, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 1, and Rhizoma Curcumae Longae extract accounts for 54, and Rhizoma Curcumae extract accounts for 15, and Ganoderma extract accounts for 30; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 3, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 25, and Rhizoma Curcumae Longae extract accounts for 60, and Rhizoma Curcumae extract accounts for 5, and Ganoderma extract accounts for 10; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 4, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 40, and Rhizoma Curcumae Longae extract accounts for 1, and Rhizoma Curcumae extract accounts for 30, and Ganoderma extract accounts for 29; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 5, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 40, and Rhizoma Curcumae Longae extract accounts for 50, and Rhizoma Curcumae extract accounts for 5, and Ganoderma extract accounts for 5; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 6, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 60, and Rhizoma Curcumae Longae extract accounts for 20, and Rhizoma Curcumae extract accounts for 10, and Ganoderma extract accounts for 10; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 7, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 20, and Rhizoma Curcumae Longae extract accounts for 20, and Rhizoma Curcumae extract accounts for 30, and Ganoderma extract accounts for 30; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 8, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 20, and Rhizoma Curcumae Longae extract accounts for 50, and Rhizoma Curcumae extract accounts for 10, and Ganoderma extract accounts for 30; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 9, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 50, and Rhizoma Curcumae Longae extract accounts for 20, and Rhizoma Curcumae extract accounts for 10, and Ganoderma extract accounts for 20; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

The medicament capsule of example 10, a kind of anti-curing oncoma (double centner), be made up of following weight (kilogram) component: Radix Sophorae Flavescentis extract accounts for 20, and Rhizoma Curcumae Longae extract accounts for 20, and Rhizoma Curcumae extract accounts for 20, and Ganoderma extract accounts for 40; Saturating 100 mesh sieves are mixed, pulverized to said components, pelletize, dress capsule.Every heavy 500mg of this product.

Claims

1, a kind of medicine of anti-curing oncoma, it is characterized in that being made up of following components in weight percentage: Radix Sophorae Flavescentis extract accounts for 1-60%, and Rhizoma Curcumae Longae extract accounts for 1-60%, and Rhizoma Curcumae extract accounts for 1-30%, and Ganoderma extract accounts for 1-60%; Sieve is thoroughly mixed, pulverized to said components, and Chinese medicine preparation is made in pelletize.

2, the medicine of a kind of anti-curing oncoma according to claim 1 is characterized in that described preparation is a capsule.

3, the medicine of a kind of anti-curing oncoma according to claim 1 is characterized in that described preparation is an electuary.

4, the medicine of a kind of anti-curing oncoma according to claim 1, it is characterized in that described component is: Radix Sophorae Flavescentis extract accounts for 20-50%, and Rhizoma Curcumae Longae extract accounts for 20-50%, and Rhizoma Curcumae extract accounts for 10-30%, and Ganoderma extract accounts for 20-50%.