CN1544074A - Chinese traditional medicine for treating optical fundus hemorrhage and its preparing process - Google Patents
Chinese traditional medicine for treating optical fundus hemorrhage and its preparing process Download PDFInfo
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Abstract
The present invention relates to a Chinese traditional medicine composing prescription used for treating optical fundus hemorrhage and method for making same. In china, there are about 20000000 persons suffering from various optical fundus hemorrhage (about 500000 patients in Shanxi provience), with a disease catching rate of 1.7%. The complication of the optical fundus hemorrhage is various, and the optical fundus hemorrhage has become the foremost disease casing one blind in china. In accordance with the present invention, on the basis of the pathogenesis of various common optical fundus hemorrhage and the corresponding treating principal adopted by herbalist doctors, based on clinical empirical prescriptions, said Chinese traditional medicine composing prescription consists of 19 Chinese herbal medicines: glutinous rehmannia, cattail pollen, radix paeoniae rubrathe, red sage root, chrysanthemum, Eclipta prostrate, cassia seed, prunella spike, scouring rush, Fructus Leonuri, baikal skullcap root (char), gentian, privet and Chinese angelica. The present invention provides a Chinese traditional medicine compound recipe formulation with cooperation of Monarch, Minister, Assistant and Guide, short period of treatment, fast effects, high strengthening rate, without clinical toxic and side effects and recurrences, and method for making same.
Description
One, technical field:
The present invention relates to the retinal hemorrhage disease that a kind of treatment causes because of a variety of causes, medicament composing prescription as symptoms such as retinal hemorrhage, central retinal vein occlusion, periphlebitis of retina, disciform macular degeneration, papillitises, specifically describe is to be raw material with the Chinese herbal medicine, through a kind of hyperactivity of fire caused by deficiency of YIN that is used for that the process Processing of Preparation forms, pure compound Chinese medicinal preparation of diseases such as the caused various retinal hemorrhage of thermal burn channels and preparation method thereof.
Two, background technology:
Eyes are windows of the mankind's soul, according to statistics, human understanding to surrounding, 86% will just can finish by eyes, so the activity of all complexity all will be inspected by eyes, but the eyes pathological changes of bringing out along with factors such as environment in recent years are polluted, spiritual tired anxiety is more and more, pathological changes in various degree can cause visual deterioration, and is fuzzy even blind.This invention has specially good effect to treating various retinal hemorrhage.Therefore, the retinal hemorrhage central retinal vein occlusion that causes at clinical common a variety of causes, disciform macular degeneration, vitreous hemorrhage, papillitis etc., and the internal medicine common complication see at most be: hypertension, arteriosclerosis, diabetes, the retinal vessel that nephritis etc. cause changes, and belongs to the ophthalmology serious symptom more, and prevalence has in China increases trend year by year, the whole nation has 2,000 ten thousand people to suffer from various retinal hemorrhage diseases approximately, only Shaanxi Province has more than 500,000 patients approximately, and is ill up to 1.7%, more than the retinal hemorrhage complication, now become the topmost disease of China's blinding, because the harm of this disease can cause visual disorder, seriously can blinding, therefore, sought efficacious prescriptions medicine prevention ophthalmic disease, be target and the direction that domestic and international ophthalmology academia is inquired into research jointly always.
Retinal hemorrhage is equivalent to TCM Ophthalmology " sudden blindness ", " cloud and mist moves fine " oculopathy, is because damaged by excess of seven emotions, the poison of diseases caused by exogenous pathogenic factor pathogenic heat, and prolonged illness injures kidney yin, qi depression to blood stasis due to deficiency of both QI and blood and the ocular contusion, deficiency of the liver and kindey, loss of nutrient of eyes.The present invention catches the cause of disease of retinal hemorrhage, pathology and pathogeny, grind together according to traditional Chinese medical science eye body, the theory of activating blood and removing stasis Method, adopt the whole dialectical opinion of the modern medicine microscopic diagnosis and the traditional Chinese medical science to control the means that combine, according to Shaanxi well-known doctor's proved recipe sanction, develop the pure compound Chinese medicinal preparation that is used for the treatment of the various fundus hemorrhage.
Three, summary of the invention:
The object of the present invention is to provide a kind of cooling blood for hemostasis that has, blood stasis dispersing and fresh blood promoting, the effect of nourishing the liver to improve visual acuity is used for the treatment of hyperactivity of fire caused by deficiency of YIN, Chinese medicine of the caused various retinal hemorrhage diseases of thermal burn channels and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of Chinese medicine for the treatment of retinal hemorrhage disease, its special character is: the medicament that the Chinese prescription of described treatment oculopathy retinal hemorrhage disease is made by following materials of weight proportions:
Pollen Typhae 65-80 part Radix Salviae Miltiorrhizae 65-80 part Radix Rehmanniae 50-70 part
Herba Ecliptae 50-70 part Flos Chrysanthemi 40-60 part Radix Scutellariae 35-50 part
Semen Cassiae 35-50 part Semen Plantaginis 35-50 part Fructus Leonuri 35-50 part
Fructus Ligustri Lucidi 35-50 part Spica Prunellae 35-50 part Radix Gentianae 35-50 part
Radix Curcumae 20-40 part Herba Equiseti Hiemalis 35-50 part Radix Paeoniae Rubra 20-40 part
Cortex Moutan 20-40 part Fructus Crataegi 20-40 part Radix Angelicae Sinensis 20-40 part
Rhizoma Chuanxiong 5-15 part
The medicament that the Chinese medicine of above-mentioned treatment oculopathy is made by following materials of weight proportions:
60 parts of 75 portions of Radix Rehmanniae of 75 parts of Radix Salviae Miltiorrhizaes of Pollen Typhae
45 parts of 50 parts of Radix Scutellariaes of 60 parts of Flos Chrysanthemis of Herba Ecliptae
45 parts of 45 parts of Fructus Leonuris of 45 portions of Semen Plantaginiss of Semen Cassiae
45 parts of 45 parts of Radix Gentianae of 45 parts of Spica Prunellaes of Fructus Ligustri Lucidi
30 parts of 45 parts of Radix Paeoniae Rubra of 30 parts of Herba Equiseties Hiemalis of Radix Curcumae
30 parts of 30 parts of Radix Angelicae Sinensis of 30 portions of Fructus Crataegis of Cortex Moutan
10 parts of Rhizoma Chuanxiongs
Above-mentioned medicament is the above a dosage form of any pharmaceutics.
Above-mentioned dosage form is tablet, capsule.
Above-mentioned dosage form is that the processing step of preparation method of tablet is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with Flos Chrysanthemi, Radix Scutellariae, the Semen Plantaginis of half amount, the Pollen Typhae of half amount, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), remaining Semen Plantaginis, Pollen Typhae and all the other 15 flavor Chinese medicines were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression being concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, the fine powder that adds preparation in the above-mentioned steps (2) again, mix homogeneously, 60 ℃ of oven dry, granulate, add adjuvant dextrin 20-40 part, make granule with 85% ethanol, 60 ℃ of oven dry, granulate, add magnesium stearate 1-2 part, mixing, the tabletting sugar coating is promptly.
Above-mentioned dosage form is that the processing step of capsular preparation method is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with Flos Chrysanthemi, Radix Scutellariae, the Semen Plantaginis of half amount, the Pollen Typhae of half amount, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), remaining Semen Plantaginis, Pollen Typhae and all the other 15 flavor Chinese medicines were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression being concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, the fine powder that adds preparation in the above-mentioned steps (2) again, mix homogeneously, 60 ℃ of oven dry, granulate, add adjuvant dextrin 20-40 part, make granule with 85% ethanol, 60 ℃ of oven dry, granulate, mixing, encapsulated, promptly.
Above-mentioned dosage form is that the processing step of preparation method of granule is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with Flos Chrysanthemi, Radix Scutellariae, the Semen Plantaginis of half amount, the Pollen Typhae of half amount, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), remaining Semen Plantaginis, Pollen Typhae and all the other 15 flavor Chinese medicines were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression is concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, adds fine powder, 400 parts of starch, 100 portions of sucrose, 100 parts of dextrin of preparation in the above-mentioned steps (2) again, granulate, promptly.
Above-mentioned dosage form is that the processing step of preparation of soft capsule method is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), above 19 flavor medical materials were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes.
(3), filtrate decompression is concentrated into temperature is that 60 ℃, relative density are the extractum of 1.15-1.20, adjusts amount of alcohol and reaches 70%, stirs, leave standstill;
(4), reclaim ethanol, it is that 50 ℃, relative density are the extractum of 1.30-1.32 that medicinal liquid is concentrated into temperature, the decompression oven dry is ground into fine powder, adds the suspension that salad oil is mixed into 25-30%, makes soft capsule.
The present invention is with respect to prior art, and its advantage is as follows:
It is monarch that the present invention selects Pollen Tyjphae for use, and hemostasis is invigorated blood circulation, and is aided with the Herba Ecliptae cooling blood for hemostasis, the nourishing the liver QI invigorating, promoting the production of body fluid makes eye bright, and assistant is with Radix Paeoniae Rubra, Cortex Moutan, medicine clearing away heat and cooling blood such as Radix Curcumae, full side has cooling blood for hemostasis, blood stasis dispersing and fresh blood promoting, the effect of nourishing the liver to improve visual acuity, be used for hyperactivity of fire caused by deficiency of YIN, the caused various retinal hemorrhage disease effects of thermal burn channels are remarkable, clinical safe in utilization.
The present invention adopts advanced Chinese medicine processing extraction equipment, extracts with the technology of science uniqueness, separates the active ingredient method, and compound making is convenient to oral pure Chinese medicinal tablet easy to carry.This medicine has embodied treating both the principal and secondary aspects of a disease from clinical efficacy, dialectically execute control clinical the medicine principle is arranged, given prominence to Chinese medicine from characteristic and treated all kinds of retinal hemorrhage diseases in the clinical ophthalmology field and need not implement operation, eliminated the optical fundus lesions position and absorb the clinical application purpose by oral being administered into.
Pure Chinese medicinal preparation of the present invention is from technology theory, changed ancient Chinese medicine decoction method, its crucial production technology has adopted modern science Chinese medicine extraction principle, and utilization modern crafts extractive technique is according to the characteristic of prescription, take a part of crude drug in whole micronizing, the part extract drugs is separated the active ingredient technology, is convenient to control its quality standard detection, taking convenience thereby make, stable curative effect, the Chinese medicine preparation of the transportation that is easy to carry.
Four, specific embodiment:
The present invention is based on the traditional Chinese medical science to various common hemorrhage pathogeny of optical fundus portion and Therapeutic Principle, on the basis of clinical proved recipe, through studying for a long period of time, with reference to modern medical theory and clinical experience is foundation, in the side by Radix Rehmanniae, Pollen Typhae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Herba Ecliptae, Semen Cassiae, Spica Prunellae, Herba Equiseti Hiemalis, Fructus Leonuri, Radix Scutellariae (charcoal), Radix Gentianae, Fructus Ligustri Lucidi, Semen Plantaginis, Radix Curcumae, Fructus Crataegi, Rhizoma Chuanxiong 19 flavor Chinese herbal medicine are formed.
Respectively the distinguish the flavor of property of medicine of medicine of prescription of the present invention is:
1, Pollen Typhae: the pollen that belongs to various plants for Typhaceae typha plant raupo.
Nature and flavor: sweet, flat.Return liver, pericardium channel.
Performance characteristics: hemostasis, blood stasis dispelling, treating stranguria.Be used for haematemesis, epistaxis, spitting of blood, traumatic hemorrhage, blood strangury and dry pain etc.
2, Radix Salviae Miltiorrhizae: be the dry root or the rhizome of labiate Radix Salviae Miltiorrhizae.
Nature and flavor: bitter, be slightly cold.GUIXIN, pericardium, Liver Channel.
Performance characteristics: this product bitter cold is let out clearly, specially goes into blood system, both kind blood circulation promoting and blood stasis dispelling and inducing menstruation to relieve menalgia, and kind again clear away heart-fire removing heat from blood and the relieving restlessness pain that disappears cures mainly blood stasis, and heat in blood, heat are disturbed all diseases due to the mind.
3, Radix Rehmanniae: be the fresh or dried root of Scrophulariaceae Radix Rehmanniae.
Nature and flavor: sweet, bitter, cold.GUIXIN, liver, kidney channel.
Performance characteristics: clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis.Be applied to consumption of YIN caused by febrile disease, crimson tongue excessive thirst, haematemesis, epistaxis, laryngopharynx swelling and pain.
4, Herba Ecliptae: be the dry aerial parts of feverfew Eclipta prostrata.
Nature and flavor: sweet, sour, cold.Return liver, kidney channel.
Performance characteristics: nourishing YIN for benefiting the kidney, cooling blood for hemostasis.Be applied to having a dizzy spell of the hepatic and renal YIN deficiency, early whitening of beard and hair.The haematemesis of deficiency of YIN heat in blood.Nosebleed, hematuria, have blood in stool, metrorrhagia.
5, Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum.
Nature and flavor: sweet, bitter, be slightly cold.Return lung, Liver Channel.
Performance characteristics: the wind heat clearing away of loosing, suppressing the hyperactive liver makes eye bright.Be applied to conjunctival congestion and swelling pain, eyes is dim-sighted.
6, Radix Scutellariae: be the dry root of labiate Radix Scutellariae.
Nature and flavor: bitter, cold.Return lung, gallbladder, stomach, large intestine channel.
Performance characteristics: this product bitter cold is let out dampness, main lung and the large intestine, double stomach and the liver and gall of returning of returning clearly.Effect is part of the body cavity above the diaphragm housing the heart and lungs lung and large intestine relatively, the fire of kind lung heat clearing and large intestine, and except that last, damp-heat in middle-JIAO is doublely gone into blood system and removing heat from blood, heat clearing away and antiabortive.Has heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention function.
Radix Scutellariae (charcoal): Radix Scutellariae is fried into the charcoal shape with high heat.
7, Semen Cassiae: be the dry mature seed of leguminous plant Semen Cassiae.
Nature and flavor: sweet, bitter, be slightly cold.Return liver, large intestine channel.
Performance characteristics: liver heat removing and eyesight improving, loosening bowel to relieve constipation.Be applied to the conjunctival congestion and swelling pain due to liver-heat or the wind-heat of liver channel, the many tears of photophobia, accumulation of heat or dryness of the intestine, constipation.
8, Semen Plantaginis: be the dry mature seed of Plantaginaceae plant Herba Plantaginis etc.
Nature and flavor: sweet, cold.Return kidney, liver, lung meridian.
Performance characteristics: relieving stranguria by diuresis, antidiarrheal, liver heat removing and eyesight improving, removing heat from the lung and dissipating phlegm.Be applied to damp and hot dysuria, drench pain, edema, the liver-heat conjunctival congestion and swelling pain is joined the poor vision of invigorating the liver and kidney medicine treating the liver deficiency of the kidney void.
9, Fructus Leonuri: be the dry mature fruit of labiate Herba Leonuri.
Nature and flavor: hot, bitter, be slightly cold.GUIXIN bag, Liver Channel.
Performance characteristics: promoting blood flow to regulate menstruation, liver heat removing and eyesight improving is used for menoxenia, amenorrhea, dysmenorrhea, conjunctival congestion cataracta etc.
10, Fructus Ligustri Lucidi: be the dry mature fruit of Oleaceae plant Fructus Ligustri Lucidi.
Nature and flavor: sweet, bitter, cool.Return liver, kidney channel.
Performance characteristics: liver and kidney tonifying, clearing away heat to improve acuity of vision.Be applied to the visual deterioration of caused by liver and kidney deficiency.
11, Spica Prunellae: be the dry fruit ear of labiate Spica Prunellae.
Nature and flavor: hot, bitter, cold.Return liver, gallbladder meridian.
Performance characteristics: relieve inflammation or internal heat, make eye bright, eliminating stagnation, detumescence.Be applied to conjunctival congestion and swelling pain, order pearl nyctalgia, diseases such as hypertension.
12, Radix Gentianae: be the dry root of gentianaceae plant Radix Gentianae and three flower Radix Gentianae etc.
Nature and flavor: bitter, cold.Return liver, gallbladder, stomach warp.
Performance characteristics: this product bitter cold is let out dampness clearly, the main liver and gall, the double bladder of returning of returning.The both kind clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, damp and hot, kind again eliminating pathogen in the liver gallbladder excess-fire.
The swelling of the vulva pudendal pruritus that is used for damp invasion of lower energizer, leukorrhagia, eczema scrotum, jaundice due to damp-heat, the headache conjunctival congestion of flaming up of liver-fire, deaf hypochondriac pain etc.
13, Radix Curcumae: be zingiberaceous plant Radix Curcumae or Rhizoma Curcumae Longae, the dried root of Guangxi zedoary etc.
Nature and flavor: hot, bitter, cold.GUIXIN, liver, gallbladder meridian.
Performance characteristics: the hot hardship of loosing of this product is fallen, the heat clearing away of cold energy, goes into blood system energy clots absorbing removing heat from blood, but goes into the edema caused by disorder of QI promoting QI circulation for relieving depression, is the key medicine of blood-activating and qi-promoting removing heat from blood.Both kind removing blood stasis with potent drugs pain relieving, removing heat from blood clears away heart-fire, again can soothing liver-QI for relieving depression, promoting the function of the gallbladder to alleviate jaundice can also stop blooding.
14, Herba Equiseti Hiemalis: be Equisetaceae plant Herba Equiseti Hiemalis's dry aerial parts.
Nature and flavor: sweet, bitter, flat.Return lung, Liver Channel.
Performance characteristics: the wind heat of loosing, move back corneal nebula.Be applied to the wind heat conjunctival congestion, epiphora induced by wind, order is given birth to removing nebula.
15, Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae or CHUANSHAO medicine.
Nature and flavor: bitter, be slightly cold.Return Liver Channel.
Performance characteristics: this product is bitter and be slightly cold, and specially goes into Liver Channel, for letting out the diffusing product of row clearly.Both kind clearing away liver-fire removes the hot and suffocating and removing heat from blood of blood system, kind again blood circulation promoting and blood stasis dispelling and pain relieving.
16, Cortex Moutan: be the dry root bark of ranunculaceae peony.
Nature and flavor: bitter, hot, be slightly cold.GUIXIN, liver, kidney channel.
Performance characteristics: for letting out the diffusing product of row clearly, both kind clearing away heat and cooling blood, kind again blood circulation promoting and blood stasis dispelling, also double reducing the asthenic fever has removing heat from blood and does not stay the stasis of blood, invigorates blood circulation and the characteristics of motionless blood.
17, Fructus Crataegi: be the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.
Nature and flavor: sour, sweet, tepor.Return spleen, stomach, Liver Channel,
Performance characteristics: this product acid is sweet, and tepor is not hot, and promoting digestion and removing stagnation power is stronger, and the outstanding kind digestion that promotes that meat is long-pending is for controlling the long-pending key medicine of greasy meat.Go into the Liver Channel blood system again and kind promoting blood circulation to remove blood stasis, control the pain due to blood stasis warp, amenorrhea and postpartum stagnation stomachache.
18, Radix Angelicae Sinensis, be the dry root of umbelliferae angelica.
Nature and flavor: sweet, hot, warm.Return liver, the heart, spleen channel.
Performance characteristics: the sweet suffering of this product is gentle, goes into liver heart spleen channel, and kind enriching blood invigorated blood circulation, menstruction regulating and pain relieving, is the tonifying blood and regulating menstruation key medicine.Have and enrich blood, invigorate blood circulation, pain relieving, intestine moistening function etc.
19, Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong.
Nature and flavor: hot, warm.Return liver, gallbladder, pericardium channel.
Performance characteristics: the hot fragrant row of this product looses, warm promoting blood circulation, and the sea of blood is walked on last wardrobe top down.Merit is apt to blood-activating and qi-promoting, wind-expelling pain-stopping.
It is monarch that we select Pollen Tyjphae for use, and hemostasis is invigorated blood circulation, and is aided with the Herba Ecliptae cooling blood for hemostasis, the nourishing the liver QI invigorating, promoting the production of body fluid makes eye bright, and assistant is with Radix Paeoniae Rubra, Cortex Moutan, medicine clearing away heat and cooling blood such as Radix Curcumae, full side has cooling blood for hemostasis, blood stasis dispersing and fresh blood promoting, the effect of nourishing the liver to improve visual acuity, be used for hyperactivity of fire caused by deficiency of YIN, the caused various retinal hemorrhage disease effects of thermal burn channels are remarkable, clinical safe in utilization.
The present invention is made up of 19 flavor Chinese herbal medicine compositions such as Pollen Typhae, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Herba Ecliptae, Flos Chrysanthemi, Radix Scutellariae, Semen Cassiae, adopt advanced Chinese medicine processing extraction equipment, technology with the science uniqueness is extracted, separate the active ingredient method, compound making is convenient to oral pure Chinese medicinal preparation easy to carry.This medicine has embodied treating both the principal and secondary aspects of a disease from clinical efficacy, dialectically execute control clinical the medicine principle is arranged, given prominence to Chinese medicine from characteristic and treated all kinds of retinal hemorrhage diseases in the clinical ophthalmology field and need not implement operation, reached by oral administration and eliminate the optical fundus lesions position and absorb the clinical application purpose.
The present invention is a pure Chinese medicinal preparation, changed ancient Chinese medicine decoction method from technology theory, its crucial production technology has adopted modern science Chinese medicine extraction principle, and utilization modern crafts extractive technique is according to the characteristic of prescription, take a part of crude drug in whole micronizing, the part extract drugs is separated the active ingredient technology, is convenient to control its quality standard detection, taking convenience thereby make, stable curative effect, the Chinese medicine preparation of the transportation that is easy to carry.
The present invention has carried out toxicology, pharmacodynamic study through Xian Medical Univ's clinical pharmacology research to this medicine, and result of the test shows:
1, acute toxicity test: to mouse stomach administration L
D50Greater than 36g/kg, with weighing machine 480 times in clinical people's consumption per day.
2, long term toxicity test: give rat continuous irrigation stomach 90 days with 3 dosage of the present invention (100 times, 50 times, 20 multiple doses of adult's consumption), do not find toxic reaction, convalescent period does not also have the retardance toxic reaction.
3, Pharmacodynamic test of active extract studies show that: this medicine 2.5g/kg administration, and to normal mouse, rat has obvious anastalsis, can significantly improve platelet counts and accumulation functionality, capillary permeability there is obvious antagonism, can suppresses hemocyte and ooze out, help hemostasis.The abdominal cavity capillary permeability increases due to the xylol induced mice auricular concha inflammation, acetic acid, and inflammatory exudation has remarkable inhibitory action.
The pharmacodynamics test conclusion confirms that this medical instrument has tangible hemostasis, coagulant blood, short clot to absorb, function of promoting blood circulation to disperse blood clots, and have effect such as tangible antiinflammatory.
In sum, principle-method-recipe-medicines of the present invention had both met the understanding of the traditional Chinese medical science to retinal hemorrhage, have practical experience characteristic and clinical trial basis again, also has modern Chinese medicine pharmacological research basis, its prescription is rational, it is leading that this invention research reaches domestic similar drug research scientific and technological level, filled up a blank of domestic research ophthalmic retinal hemorrhage disease oral preparation of Chinese traditional medicinal.
Characteristics of the present invention are rich abundant nutrition in the medicament contg, comprise rich vegetable protein matter, animal proteinum, aminoacid, biological activity, vitamin C, vitamin B, vitamin E and some trace element thereof, human body and local physiological function be can effectively improve, eyeball local microcirculation, blood circulation promoting and blood stasis dispelling improved thereby reach, cooling blood for hemostasis recovers the effect that the optical fundus vision promotes the eye care function.
In order to show that further the present invention itemizes some clinical observations, data and case to treating below the various retinal hemorrhage clinical efficacies.Clinical research of the present invention:
Ophthalmology by three units such as the hospitals of traditional Chinese hospital in The People's Hospital, the Shaanxi Province academy of traditional Chinese medicine, the Xi'an is born.Estimate the effect that pure Chinese medicinal preparation the present invention treats the various fundus hemorrhagic disease.Provide clinical observation 347 examples, 496 eyes have been obtained good curative effect.
The present invention treats 8 kinds of retinal hemorrhage diseases, the retinal vein occlusion, periphlebitis of retina, hypertension retinopathy, diabetic renal papillary necrosis, in ooze, vitreous hemorrhage, punctum luteum hemorrhage, papillitis instant effect, have no side effect, take the remarkable result that can reach treatment and prevention of recurrence for a long time.
The physical data
Name of disease sex age eye is other
The above left and right sides, optical fundus men and women 18～20 21～40 41～60 61 eyes
Mass formed by blood stasis
347 examples 231 143 30 79 138 127 139 161 85
The classification
The quiet retinal vein diabetes of retina are looked macula lutea optic disc blood vitreous body hypertension and are looked
Scorching nethike embrane pathological changes went out to ooze the nethike embrane pathological changes in the vasculitis hematocele around arteries and veins blocked
Example several 92 64 19 78 34 37 48 2
Eye several 92 98 38 112 34 37 56 2
The criterion of therapeutical effect
1, clinical cure: vision restoration to 1.0 is above or return to premorbid vision, retinal hemorrhage basic absorption.Optical fundus blood vessel fluoroscopic visualization vein is normal substantially.
2, produce effects: vision improves more than 4 row, most of absorb (1/2～1/3) of retinal hemorrhage, and optical fundus blood vessel fluoroscopic visualization vein has clear improvement.
3, effective: it is capable that vision improves 1-3.Retinal hemorrhage partially absorbs 1/3, and optical fundus pipe fluoroscopic visualization vein makes moderate progress.
4, invalid: vision no change or decline.Retinal hemorrhage no change or increase.Optical fundus light radiography no change or deterioration.
Annotate: 0.1 following vision whenever adds 0.02 and calculates delegation.
Index is effective for light sensation---manually effectively manually---
--0.02 produce effects--0.04 produce effects
Index--0.04 effective 0.02--0.06 is effective
The therapeutic outcome
The result cures the effectively invalid eye of eye total effective rate of a produce effects eye
Classification (%) is (%) (%) (%) (%)
Retinal vein 11 31 35 15
Block (11.96%) (33.7%) (38.04%) (16.3%) 83.64%
Retinal vein 16 30 31 21
Scorching on every side (16.32%) (30.62%) (31.63%) (21.43%) 78.57%
Diabetes view 10 10 12 6
Film pathological changes (26.32%) (26.32%) (31.57%) (15.79%) 84.21%
Hypertension view 1001
Film pathological changes (50%) 00 (50%) 50%
Papillitis 10 10 95
(29.41％) (29.41％) (26.47％) (14.71％) 85.29％
Vitreous hemorrhage 10 9 11 7
(27.03％) (24.32％) (29.73％) (18.72％) 81.80％
Punctum luteum hemorrhage 17 31 42 22
(15.18％) (27.68％) (37.5％) (19.64％) 80.36％
In ooze 9 17 18 12
(16.07％) (30.36％) (32.14％) (21.43％) 78.57％
discusses
1, retinal hemorrhage disease is that ophthalmic diseases is one of common, punishes severely the infringement visual function, influences patient's work, study and life.We use cooling blood for hemostasis of the present invention, blood circulation promoting and blood stasis dispelling, and nourishing the liver to improve visual acuity, the retinal hemorrhage disease pathogenesis that can hit plays a multiplier role.
2, the present invention's treatment: 92 eyes of the retinal vein occlusion, total effective rate is 83.64%, 98 eyes of periphlebitis of retina, total effective rate is 78.57%, 38 eyes of diabetic renal papillary necrosis, and total effective rate is 85.29%, 37 eyes of vitreous hemorrhage, total effective rate is 81.085%, hemorrhage 112 eyes of yellow class, total effective rate 80.36%, in ooze 56 eyes, total effective rate 78.57%, 2 eyes of hypertension retinopathy, total effective rate 50%.
3, the present invention is motherland's medical therapy, and pure Chinese medicinal preparation is tablet, and taking convenience has indication widely, and curative effect is sure, takes for a long time and does not find any toxic and side effects, for new route of administration has been started in the treatment at the bottom of the retinal hemorrhage.
Model case:
1, Xi'an building constructor, Sun Wei, man, 61 years old, the retired worker, the main suit is because of retinal hemorrhage causes the glass spheres muddiness, visual deterioration, right eye are 0.6, left eye 0.3, it is not good to take other multiple ophthalmic effect of drugs of drop, after ophthalmologist diagnosis, makes a definite diagnosis because of hypertension and has guided the optical fundus hemorrhage, the glass spheres muddiness recommends to take the present invention's box more than 20, and the clothes back state of an illness takes a favorable turn, vision restoration is to right eye 0.8, and left eye is more than 0.6, and optical fundus hyperemia fades away.
2, Shaanxi clock and watch institute, Hua Zhiqiang, man, 58 years old.The main suit suffered from diabetes 2 years, and vision descends suddenly recently, the sugar (on an empty stomach) of having a blood test is 10.2mmOl/L, after diagnosing, because of diabetes cause optical fundus hyperemia, right vision 0.5, left vision 0.4, behind clothes the present invention 5 boxes, self-induction is effective, take 20 boxes again after effect obvious, revert to 0.8 through looking into right vision, left vision reverts to 0.7.
3, Liu Jie, woman, 52 years old, the workman, vision plunges blurred vision recently, with hypertension history, doublely see dizziness and tinnitus, dysphoria with feverish sensation in the chest palms and soles, through looking into: look nipple hyperemia, obscurity boundary, retina the higher authorities flame head is hemorrhage, be diagnosed as the retinal vein occlusion, clothes rutosids, vitamin C, effects such as iodine preparation are not obvious, change clothes " the present invention " after 30 days.Retinal blood flow speed increases, hemorrhage basic absorption around the blood capillary.
4, Hao Jingfan, man, 62 years old, the cadre, suffer from periphlebitis of retina, hemorrhage repeatedly, have pulmonary concurrently and open nuclear, a large amount of hematoceles in looking into vitreous body, white sheath is arranged around the blood vessel, take " the present invention " after 40 days, hemorrhagely stop, oligemia in the vitreous body, carry out successively anti-consumptive disease and retina on every side inflammation treat simultaneously.
Embodiment 1
Pollen Typhae 75g Radix Salviae Miltiorrhizae 75g Radix Rehmanniae 60g Herba Ecliptae 60g
Flos Chrysanthemi 50g Radix Scutellariae (charcoal) 45g Semen Cassiae 45g Semen Plantaginis 45g
Fructus Leonuri 45g Fructus Ligustri Lucidi 45g Spica Prunellae 45g Radix Gentianae 45g
Radix Curcumae 30g Herba Equiseti Hiemalis 45g Radix Paeoniae Rubra 30g Cortex Moutan 30g
Fructus Crataegi 30g Radix Angelicae Sinensis 30g Rhizoma Chuanxiong 10g
Above-mentioned dosage form is that the processing step of preparation method of tablet is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with the Radix Scutellariae of preparation in the step (1) of 50g Flos Chrysanthemi, 45g, 22.5g Semen Plantaginis and 37.5g Pollen Typhae, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), the Semen Plantaginis of remaining 22.5g, Pollen Typhae and all the other the 15 flavor Chinese medicines of 37.5g were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression is concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, adds the fine powder of preparation in the above-mentioned steps (2) again, mix homogeneously, 60 ℃ of oven dry, granulate adds adjuvant dextrin 30g, make granule with 85% ethanol, 60 ℃ of oven dry, granulate adds magnesium stearate 1.5g, mixing, tabletting is made every heavy 0.3 tablet that restrains, and sugar coating promptly.
Embodiment 2
Pollen Typhae 65g Radix Salviae Miltiorrhizae 65g Radix Rehmanniae 50g Herba Ecliptae 50g
Flos Chrysanthemi 40g Radix Scutellariae (charcoal) 35g Semen Cassiae 35g Semen Plantaginis 35g
Fructus Leonuri 35g Fructus Ligustri Lucidi 35g Spica Prunellae 35g Radix Gentianae 35g
Radix Curcumae 20g Herba Equiseti Hiemalis 35g Radix Paeoniae Rubra 20g Radix Angelicae Sinensis 20g
Cortex Moutan 20g Fructus Crataegi 20g Rhizoma Chuanxiong 5g
Above-mentioned dosage form is that the processing step of capsular preparation method is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with the Radix Scutellariae of preparation in the step (1) of 40g Flos Chrysanthemi, 35g, 17.5g Semen Plantaginis and 32.5g Pollen Typhae, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), the Semen Plantaginis of remaining 17.5g, Pollen Typhae and all the other the 15 flavor Chinese medicines of 32.5g were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression being concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, the fine powder that adds preparation in the above-mentioned steps (2) again, mix homogeneously, 60 ℃ of oven dry, be ground into fine powder, add dextrin 20g, make granule with 85% ethanol, 60 ℃ of oven dry, granulate, mixing, encapsulated, promptly.
Embodiment 3
Pollen Typhae 80g Radix Salviae Miltiorrhizae 80g Radix Rehmanniae 70g Herba Ecliptae 70g
Flos Chrysanthemi 60g Radix Scutellariae (charcoal) 50g Semen Cassiae 50g Semen Plantaginis 50g
Fructus Leonuri 50g Fructus Ligustri Lucidi 50g Spica Prunellae 50g Radix Gentianae 50g
Radix Curcumae 40g Herba Equiseti Hiemalis 50g Radix Paeoniae Rubra 40g Radix Angelicae Sinensis 40g
Cortex Moutan 40g Fructus Crataegi 40g Rhizoma Chuanxiong 15g
The raw material of said ratio is made tablet or capsule by embodiment 1 or embodiment 2 described production technology preparation methoies.
Embodiment 4:
Pollen Typhae 75g Radix Salviae Miltiorrhizae 75g Radix Rehmanniae 60g Herba Ecliptae 60g
Flos Chrysanthemi 50g Radix Scutellariae (charcoal) 45g Radix Curcumae 30g Semen Cassiae 45g
Herba Equiseti Hiemalis 45g Semen Plantaginis 45g Radix Paeoniae Rubra 30g Fructus Leonuri 45g
Fructus Crataegi 30g Fructus Ligustri Lucidi 45g Radix Angelicae Sinensis 30g Spica Prunellae 45g
Radix Gentianae 45g Cortex Moutan 30g Rhizoma Chuanxiong 10g
Above-mentioned dosage form is that the processing step of preparation method of granule is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with Flos Chrysanthemi, Radix Scutellariae, the Semen Plantaginis of half amount, the Pollen Typhae of half amount, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), remaining Semen Plantaginis, Pollen Typhae and all the other 15 flavor Chinese medicines were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression is concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, adds fine powder, 400g starch, 100g sucrose, the 100g dextrin of preparation in the above-mentioned steps (2) again, granulate, promptly.
Embodiment 5:
Pollen Typhae 75g Radix Salviae Miltiorrhizae 75g Radix Rehmanniae 60g Herba Ecliptae 60g
Flos Chrysanthemi 50g Radix Scutellariae (charcoal) 45g Radix Curcumae 30g Semen Cassiae 45g
Herba Equiseti Hiemalis 45g Semen Plantaginis 45g Radix Paeoniae Rubra 30g Fructus Leonuri 45g
Fructus Crataegi 30g Fructus Ligustri Lucidi 45g Radix Angelicae Sinensis 30g Spica Prunellae 45g
Radix Gentianae 45g Cortex Moutan 30g Rhizoma Chuanxiong 10g
Above-mentioned dosage form is that the processing step of preparation of soft capsule method is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), above 19 flavor medical materials were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes.
(3), filtrate decompression is concentrated into temperature is that 60 ℃, relative density are the extractum of 1.15-1.20, adjusts amount of alcohol and reaches 70%, stirs, leave standstill;
(4), reclaim ethanol, it is that 50 ℃, relative density are the extractum of 1.30-1.32 that medicinal liquid is concentrated into temperature, the decompression oven dry is ground into fine powder, adds the suspension that salad oil is mixed into 25-30%, makes 1000 soft capsules.
Claims (8)
1, a kind of Chinese medicine for the treatment of retinal hemorrhage disease is characterized in that: the medicament that the Chinese prescription of described treatment oculopathy retinal hemorrhage disease is made by following materials of weight proportions:
Pollen Typhae 65-80 part Radix Salviae Miltiorrhizae 65-80 part Radix Rehmanniae 50-70 part
Herba Ecliptae 50-70 part Flos Chrysanthemi 40-60 part Radix Scutellariae 35-50 part
Semen Cassiae 35-50 part Semen Plantaginis 35-50 part Fructus Leonuri 35-50 part
Fructus Ligustri Lucidi 35-50 part Spica Prunellae 35-50 part Radix Gentianae 35-50 part
Radix Curcumae 20-40 part Herba Equiseti Hiemalis 35-50 part Radix Paeoniae Rubra 20-40 part
Cortex Moutan 20-40 part Fructus Crataegi 20-40 part Radix Angelicae Sinensis 20-40 part
Rhizoma Chuanxiong 5-15 part
2, a kind of Chinese medicine for the treatment of retinal hemorrhage disease according to claim 1 is characterized in that: the medicament that the Chinese medicine of described treatment oculopathy is made by following materials of weight proportions:
60 parts of 75 portions of Radix Rehmanniae of 75 parts of Radix Salviae Miltiorrhizaes of Pollen Typhae
45 parts of 50 parts of Radix Scutellariaes of 60 parts of Flos Chrysanthemis of Herba Ecliptae
45 parts of 45 parts of Fructus Leonuris of 45 portions of Semen Plantaginiss of Semen Cassiae
45 parts of 45 parts of Radix Gentianae of 45 parts of Spica Prunellaes of Fructus Ligustri Lucidi
30 parts of 45 parts of Radix Paeoniae Rubra of 30 parts of Herba Equiseties Hiemalis of Radix Curcumae
30 parts of 30 parts of Radix Angelicae Sinensis of 30 portions of Fructus Crataegis of Cortex Moutan
10 parts of Rhizoma Chuanxiongs
3, a kind of Chinese medicine for the treatment of retinal hemorrhage disease according to claim 1 and 2 is characterized in that: described medicament is the above a dosage form of any pharmaceutics.
4, a kind of Chinese medicine for the treatment of retinal hemorrhage disease according to claim 3, it is characterized in that: described dosage form is tablet, capsule.
5, a kind of Chinese medicine for the treatment of retinal hemorrhage disease according to claim 4 is characterized in that: described dosage form is that the processing step of preparation method of tablet is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with Flos Chrysanthemi, Radix Scutellariae, the Semen Plantaginis of half amount, the Pollen Typhae of half amount, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), remaining Semen Plantaginis, Pollen Typhae and all the other 15 flavor Chinese medicines were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression being concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, the fine powder that adds preparation in the above-mentioned steps (2) again, mix homogeneously, 60 ℃ of oven dry, granulate, add adjuvant dextrin 20-40 part, make granule with 85% ethanol, 60 ℃ of oven dry, granulate, add magnesium stearate 1-2 part, mixing, the tabletting sugar coating is promptly.
6, a kind of Chinese medicine for the treatment of retinal hemorrhage disease according to claim 4, it is characterized in that: described dosage form is that the processing step of capsular preparation method is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with Flos Chrysanthemi, Radix Scutellariae, the Semen Plantaginis of half amount, the Pollen Typhae of half amount, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), remaining Semen Plantaginis, Pollen Typhae and all the other 15 flavor Chinese medicines were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression being concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, the fine powder that adds preparation in the above-mentioned steps (2) again, mix homogeneously, 60 ℃ of oven dry, granulate, add adjuvant dextrin 20-40 part, make granule with 85% ethanol, 60 ℃ of oven dry, granulate, mixing, encapsulated, promptly.
7, a kind of Chinese medicine for the treatment of retinal hemorrhage disease according to claim 3 is characterized in that: described dosage form is that the processing step of preparation method of granule is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), with Flos Chrysanthemi, Radix Scutellariae, the Semen Plantaginis of half amount, the Pollen Typhae of half amount, mixed powder is broken into 80-120 purpose fine powder, and is standby;
(3), remaining Semen Plantaginis, Pollen Typhae and all the other 15 flavor Chinese medicines were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes;
(4), filtrate decompression is concentrated into temperature is that 60 ℃, relative density are the thick paste of 1.35-1.39, adds fine powder, 400 parts of starch, 100 portions of sucrose, 100 parts of dextrin of preparation in the above-mentioned steps (2) again, granulate, promptly.
8, a kind of Chinese medicine for the treatment of retinal hemorrhage disease according to claim 3, it is characterized in that: described dosage form is that the processing step of preparation of soft capsule method is as follows:
(1), Radix Scutellariae is fried into the charcoal shape with high heat, standby;
(2), above 19 flavor medical materials were soaked decoction secondary, each 2 hours, collecting decoction, filtration 30 minutes.
(3), filtrate decompression is concentrated into temperature is that 60 ℃, relative density are the extractum of 1.15-1.20, adjusts amount of alcohol and reaches 70%, stirs, leave standstill;
(4), reclaim ethanol, it is that 50 ℃, relative density are the extractum of 1.30-1.32 that medicinal liquid is concentrated into temperature, the decompression oven dry is ground into fine powder, adds the suspension that salad oil is mixed into 25-30%, makes soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410038250 CN1276775C (en) | 2003-05-21 | 2004-05-18 | Chinese traditional medicine for treating optical fundus hemorrhage and its preparing process |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03108059 CN1451422A (en) | 2003-05-21 | 2003-05-21 | Chinese medicine for treating fundus oculi bleeding |
| CN03108059.6 | 2003-05-21 | ||
| CN 200410038250 CN1276775C (en) | 2003-05-21 | 2004-05-18 | Chinese traditional medicine for treating optical fundus hemorrhage and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1544074A true CN1544074A (en) | 2004-11-10 |
| CN1276775C CN1276775C (en) | 2006-09-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410038250 Expired - Lifetime CN1276775C (en) | 2003-05-21 | 2004-05-18 | Chinese traditional medicine for treating optical fundus hemorrhage and its preparing process |
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| Country | Link |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102151312A (en) * | 2011-03-22 | 2011-08-17 | 孙丰卿 | Medicament for treating vitreous hematocele and preparation method thereof |
| CN102319398A (en) * | 2011-09-26 | 2012-01-18 | 西安碑林药业股份有限公司 | A kind of and the blood Chinese medicine composition and preparation method thereof that makes eye bright |
| CN102319400A (en) * | 2011-09-26 | 2012-01-18 | 西安碑林药业股份有限公司 | Traditional Chinese drug composition for blood cooling, hemostasis, yin nourishing, blood stasis dissipating, liver nourishing and eyesight improving, and preparation method thereof |
| CN104800559A (en) * | 2015-04-26 | 2015-07-29 | 任荣源 | Medicine for treating fundus hemorrhage |
| CN105596625A (en) * | 2016-02-03 | 2016-05-25 | 王海凤 | Traditional Chinese medicine preparation for treating retinal vasculitis |
| CN114588236A (en) * | 2020-12-03 | 2022-06-07 | 西安碑林药业股份有限公司 | Use of a composition for the manufacture of a medicament |
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2004
- 2004-05-18 CN CN 200410038250 patent/CN1276775C/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102151312A (en) * | 2011-03-22 | 2011-08-17 | 孙丰卿 | Medicament for treating vitreous hematocele and preparation method thereof |
| CN102151312B (en) * | 2011-03-22 | 2013-03-13 | 孙丰卿 | Medicament for treating vitreous hematocele and preparation method thereof |
| CN102319398A (en) * | 2011-09-26 | 2012-01-18 | 西安碑林药业股份有限公司 | A kind of and the blood Chinese medicine composition and preparation method thereof that makes eye bright |
| CN102319400A (en) * | 2011-09-26 | 2012-01-18 | 西安碑林药业股份有限公司 | Traditional Chinese drug composition for blood cooling, hemostasis, yin nourishing, blood stasis dissipating, liver nourishing and eyesight improving, and preparation method thereof |
| CN102319400B (en) * | 2011-09-26 | 2012-11-28 | 西安碑林药业股份有限公司 | Traditional Chinese drug composition for blood cooling, hemostasis, yin nourishing, blood stasis dissipating, liver nourishing and eyesight improving, and preparation method thereof |
| CN102319398B (en) * | 2011-09-26 | 2012-11-28 | 西安碑林药业股份有限公司 | Blood-nourishing and eyesight-improving Chinese medicinal composition and preparation method thereof |
| CN104800559A (en) * | 2015-04-26 | 2015-07-29 | 任荣源 | Medicine for treating fundus hemorrhage |
| CN105079460A (en) * | 2015-04-26 | 2015-11-25 | 任荣源 | Medicine for treating fundus hemorrhage |
| CN104800559B (en) * | 2015-04-26 | 2016-01-06 | 美亚药业海安有限公司 | A kind of medicine for the treatment of retinal hemorrhage |
| CN105596625A (en) * | 2016-02-03 | 2016-05-25 | 王海凤 | Traditional Chinese medicine preparation for treating retinal vasculitis |
| CN114588236A (en) * | 2020-12-03 | 2022-06-07 | 西安碑林药业股份有限公司 | Use of a composition for the manufacture of a medicament |
| CN114588236B (en) * | 2020-12-03 | 2023-10-27 | 西安碑林药业股份有限公司 | Use of a composition in the preparation of a medicament |
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| CN1276775C (en) | 2006-09-27 |
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